GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	168278159	189756	0	None	23	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assay	ChEMBL	839	15	5	15	6.6	Nc1sc(-c2ccc(-c3cn(CCCCCCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)nn3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL5177040	189756	0	None	23	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assay	ChEMBL	839	15	5	15	6.6	Nc1sc(-c2ccc(-c3cn(CCCCCCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)nn3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	168278159	189756	0	None	23	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	839	15	5	15	6.6	Nc1sc(-c2ccc(-c3cn(CCCCCCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)nn3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL5177040	189756	0	None	23	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	839	15	5	15	6.6	Nc1sc(-c2ccc(-c3cn(CCCCCCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)nn3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	9975036	16137	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as increase in cAMP productionAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as increase in cAMP production	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1cccc(O)c1	10.1021/acs.jmedchem.6b00552
	CHEMBL122806	16137	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as increase in cAMP productionAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as increase in cAMP production	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1cccc(O)c1	10.1021/acs.jmedchem.6b00552
	9975036	16137	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1cccc(O)c1	10.1021/jm049947s
	CHEMBL122806	16137	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1cccc(O)c1	10.1021/jm049947s
	71657835	159178	2	None	-1	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL4104819	159178	2	None	-1	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	44423814	141554	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	611	9	5	11	2.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(Br)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL388193	141554	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	611	9	5	11	2.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(Br)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	9869857	66481	7	None	-213	5	Human	6.0	pEC50	=	6	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL186113	66481	7	None	-213	5	Human	6.0	pEC50	=	6	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	49870952	58497	0	None	-831	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells by cyclic AMP functional assayAgonist activity at human adenosine A2B receptor expressed in CHO cells by cyclic AMP functional assay	ChEMBL	333	3	3	8	0.9	CCCCC#Cc1nc(N)c2ncn([C@@H]3SC[C@@H](O)[C@H]3O)c2n1	10.1021/ml1001823
	CHEMBL1688378	58497	0	None	-831	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells by cyclic AMP functional assayAgonist activity at human adenosine A2B receptor expressed in CHO cells by cyclic AMP functional assay	ChEMBL	333	3	3	8	0.9	CCCCC#Cc1nc(N)c2ncn([C@@H]3SC[C@@H](O)[C@H]3O)c2n1	10.1021/ml1001823
	219024	3236	61	None	-51	3	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1021/jm4011669
	2362	3236	61	None	-51	3	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1021/jm4011669
	5596	3236	61	None	-51	3	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1021/jm4011669
	CHEMBL317052	3236	61	None	-51	3	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1021/jm4011669
	DB06213	3236	61	None	-51	3	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1021/jm4011669
	9910098	70324	26	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	421	6	4	10	0.3	Nc1nc(OCCc2ccc(Cl)cc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm4011669
	CHEMBL1950553	70324	26	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	421	6	4	10	0.3	Nc1nc(OCCc2ccc(Cl)cc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm4011669
	118732976	117999	0	None	-213	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	427	5	3	12	0.4	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N[C@H]5C[C@@H]6CC[C@@H]5C6)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414942	117999	0	None	-213	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	427	5	3	12	0.4	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N[C@H]5C[C@@H]6CC[C@@H]5C6)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	377	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm049947s
	425	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm049947s
	448222	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm049947s
	CHEMBL464859	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm049947s
	44423816	84780	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	601	9	5	11	2.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccccc5C(F)(F)F)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL225579	84780	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	601	9	5	11	2.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccccc5C(F)(F)F)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	16203542	84760	0	None	-3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	504	6	5	10	0.9	Nc1nc(OCCc2c[nH]c3cc(Br)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL225459	84760	0	None	-3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	504	6	5	10	0.9	Nc1nc(OCCc2c[nH]c3cc(Br)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	145965471	163613	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	376	6	2	7	3.5	CCOc1ccc(-c2c(C#N)c(N)nc(SCc3ncc[nH]3)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4210592	163613	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	376	6	2	7	3.5	CCOc1ccc(-c2c(C#N)c(N)nc(SCc3ncc[nH]3)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	377	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061278q
	425	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061278q
	448222	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061278q
	CHEMBL464859	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061278q
	137659441	158541	0	None	-87	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	441	6	3	12	0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(F)c5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4097468	158541	0	None	-87	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	441	6	3	12	0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(F)c5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	123683	3060	58	None	-1258	5	Human	5.0	pEC50	=	5.0	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm9804984
	422	3060	58	None	-1258	5	Human	5.0	pEC50	=	5.0	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm9804984
	CHEMBL119709	3060	58	None	-1258	5	Human	5.0	pEC50	=	5.0	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm9804984
	DB05511	3060	58	None	-1258	5	Human	5.0	pEC50	=	5.0	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm9804984
	118732981	118004	0	None	-38	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	495	5	3	12	2.0	CCn1nnc([C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414947	118004	0	None	-38	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	495	5	3	12	2.0	CCn1nnc([C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	11352497	122439	0	None	-416	3	Human	5.9	pEC50	=	5.9	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	498	8	6	15	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(O)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL360837	122439	0	None	-416	3	Human	5.9	pEC50	=	5.9	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	498	8	6	15	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(O)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	118732975	117998	0	None	-173	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	407	5	3	12	0.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414941	117998	0	None	-173	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	407	5	3	12	0.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	132991435	180206	0	None	-123	4	Human	6.9	pEC50	=	6.9	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	558	8	5	12	0.8	O=C(NCc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)c1ccc(S(=O)(=O)F)cc1	10.1021/acs.jmedchem.6b01561
	CHEMBL4756472	180206	0	None	-123	4	Human	6.9	pEC50	=	6.9	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	558	8	5	12	0.8	O=C(NCc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)c1ccc(S(=O)(=O)F)cc1	10.1021/acs.jmedchem.6b01561
	57388054	75117	0	None	-17	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	607	12	5	10	3.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042305	75117	0	None	-17	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	607	12	5	10	3.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	135543624	16118	20	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccc(O)cc1	10.1021/jm049947s
	CHEMBL122622	16118	20	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccc(O)cc1	10.1021/jm049947s
	377	2707	47	None	-48	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	425	2707	47	None	-48	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	448222	2707	47	None	-48	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	CHEMBL464859	2707	47	None	-48	10	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	44423813	168173	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	567	9	5	11	2.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(Cl)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL437168	168173	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	567	9	5	11	2.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(Cl)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	145974358	163926	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	455	8	2	7	4.3	N#Cc1c(N)nc(SCc2cccc(C(N)=O)c2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4214347	163926	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	455	8	2	7	4.3	N#Cc1c(N)nc(SCc2cccc(C(N)=O)c2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	57387596	75123	0	None	-60	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	492	7	4	9	1.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(F)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042311	75123	0	None	-60	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	492	7	4	9	1.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(F)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	11386951	66536	0	None	-389	2	Human	5.9	pEC50	=	5.9	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	527	9	5	16	-0.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc([N+](=O)[O-])cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL186403	66536	0	None	-389	2	Human	5.9	pEC50	=	5.9	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	527	9	5	16	-0.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc([N+](=O)[O-])cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	57385043	75122	0	None	-134	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	810	18	6	13	6.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)CCCC[C@H]5CCSS5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042310	75122	0	None	-134	4	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	810	18	6	13	6.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)CCCC[C@H]5CCSS5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	76329266	105569	0	None	-3	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	399	5	5	10	-0.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133160	105569	0	None	-3	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	399	5	5	10	-0.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	16203665	136142	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	456	7	5	11	0.1	COc1ccc2[nH]cc(CCOc3nc(N)c4ncn([C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)c4n3)c2c1	10.1021/jm061278q
	CHEMBL374028	136142	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	456	7	5	11	0.1	COc1ccc2[nH]cc(CCOc3nc(N)c4ncn([C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)c4n3)c2c1	10.1021/jm061278q
	76311197	105565	0	None	-31	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	365	6	5	10	-1.0	CCCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1039/C3MD00364G
	CHEMBL3133156	105565	0	None	-31	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	365	6	5	10	-1.0	CCCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1039/C3MD00364G
	168282699	190414	0	None	-12022	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	427	6	4	10	0.9	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5186757	190414	0	None	-12022	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	427	6	4	10	0.9	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	57387824	75111	0	None	-8	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	442	7	6	11	-0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(N)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042299	75111	0	None	-8	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	442	7	6	11	-0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(N)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	16203542	84760	0	None	-3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	504	6	5	10	0.9	Nc1nc(OCCc2c[nH]c3cc(Br)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL225459	84760	0	None	-3	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	504	6	5	10	0.9	Nc1nc(OCCc2c[nH]c3cc(Br)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	137651756	156932	0	None	-91	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATPAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATP	ChEMBL	355	4	3	9	-0.1	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@@H]4CCOC4)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.7b01399
	CHEMBL4079464	156932	0	None	-91	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATPAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATP	ChEMBL	355	4	3	9	-0.1	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@@H]4CCOC4)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.7b01399
	137657841	159011	0	None	-50	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	475	6	3	12	1.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccc(Cl)cc5F)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4102750	159011	0	None	-50	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	475	6	3	12	1.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccc(Cl)cc5F)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	9869857	66481	7	None	-213	5	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm4011669
	CHEMBL186113	66481	7	None	-213	5	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm4011669
	11352497	122439	0	None	-416	3	Human	5.9	pEC50	=	5.9	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	498	8	6	15	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(O)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL360837	122439	0	None	-416	3	Human	5.9	pEC50	=	5.9	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	498	8	6	15	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(O)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	11157262	123110	0	None	-537	3	Human	5.9	pEC50	=	5.9	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	560	8	5	14	0.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Br)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL361925	123110	0	None	-537	3	Human	5.9	pEC50	=	5.9	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	560	8	5	14	0.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Br)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	71459958	78794	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	336	3	4	9	-0.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=S)NC2CC2)[C@@H](O)[C@H]1O	10.1021/jm9804984
	CHEMBL2113421	78794	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	336	3	4	9	-0.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=S)NC2CC2)[C@@H](O)[C@H]1O	10.1021/jm9804984
	118732978	118001	0	None	-154	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	403	5	3	13	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CCCO5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414944	118001	0	None	-154	4	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	403	5	3	13	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CCCO5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	145977469	163429	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	402	7	2	7	3.9	N#Cc1c(N)nc(SCc2cnc[nH]2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4208189	163429	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	402	7	2	7	3.9	N#Cc1c(N)nc(SCc2cnc[nH]2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	57387594	75116	0	None	-16	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	506	8	4	9	2.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(F)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042304	75116	0	None	-16	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	506	8	4	9	2.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(F)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	377	2707	47	None	-48	10	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061278q
	425	2707	47	None	-48	10	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061278q
	448222	2707	47	None	-48	10	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061278q
	CHEMBL464859	2707	47	None	-48	10	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061278q
	24827417	95887	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	ChEMBL	729	12	6	12	4.1	O=C(COc1ccc(Nc2nc(OCCc3c[nH]c4cc(Br)ccc34)nc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)Nc1ccccc1	10.1021/jm701442d
	CHEMBL261546	95887	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	ChEMBL	729	12	6	12	4.1	O=C(COc1ccc(Nc2nc(OCCc3c[nH]c4cc(Br)ccc34)nc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)Nc1ccccc1	10.1021/jm701442d
	9954747	136574	13	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	437	6	4	10	0.8	Nc1nc(OCCc2ccc3ccccc3c2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL374760	136574	13	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	437	6	4	10	0.8	Nc1nc(OCCc2ccc3ccccc3c2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	149362	75110	6	None	-12	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	427	7	5	10	-0.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042298	75110	6	None	-12	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	427	7	5	10	-0.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	168290627	191395	0	None	3	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	859	11	6	13	6.6	Nc1sc(-c2ccc(C(=O)NCCC#Cc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL5201533	191395	0	None	3	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	859	11	6	13	6.6	Nc1sc(-c2ccc(C(=O)NCCC#Cc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	137656845	159237	0	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	800	15	5	12	6.5	O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccc(-c2scc(C(=O)c3ccccc3)c2-c2cccc(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4105473	159237	0	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	800	15	5	12	6.5	O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccc(-c2scc(C(=O)c3ccccc3)c2-c2cccc(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.8b00047
	118732972	117995	0	None	-234	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	347	4	3	12	-1.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414938	117995	0	None	-234	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	347	4	3	12	-1.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	57384287	75113	0	None	-33	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	658	9	6	11	3.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042301	75113	0	None	-33	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	658	9	6	11	3.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	11776764	7802	12	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	248	2	1	8	1.1	CSc1nc(N)n2nc(-c3ccco3)nc2n1	10.1016/j.bmc.2010.02.039
	CHEMBL1090123	7802	12	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	248	2	1	8	1.1	CSc1nc(N)n2nc(-c3ccco3)nc2n1	10.1016/j.bmc.2010.02.039
	44423812	84934	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	551	9	5	11	1.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(F)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226194	84934	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	551	9	5	11	1.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(F)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	377	2707	47	None	-48	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.8b00047
	425	2707	47	None	-48	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.8b00047
	448222	2707	47	None	-48	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.8b00047
	CHEMBL464859	2707	47	None	-48	10	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.8b00047
	44423824	137047	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	547	10	5	11	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NCc5ccccc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL375501	137047	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	547	10	5	11	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NCc5ccccc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	377	2707	47	None	-48	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter methodAgonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter method	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.7b00457
	425	2707	47	None	-48	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter methodAgonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter method	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.7b00457
	448222	2707	47	None	-48	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter methodAgonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter method	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.7b00457
	CHEMBL464859	2707	47	None	-48	10	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter methodAgonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter method	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.7b00457
	377	2707	47	None	-48	10	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmc.2007.01.055
	425	2707	47	None	-48	10	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmc.2007.01.055
	448222	2707	47	None	-48	10	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmc.2007.01.055
	CHEMBL464859	2707	47	None	-48	10	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmc.2007.01.055
	137649841	156876	0	None	-1	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	656	14	5	12	3.8	O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1cccc(-c2cc(C(=O)c3ccccc3)cs2)c1	10.1021/acs.jmedchem.8b00047
	CHEMBL4078771	156876	0	None	-1	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	656	14	5	12	3.8	O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1cccc(-c2cc(C(=O)c3ccccc3)cs2)c1	10.1021/acs.jmedchem.8b00047
	76311194	105553	0	None	-100	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	525	5	5	10	-0.0	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133078	105553	0	None	-100	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	525	5	5	10	-0.0	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	76329263	105554	0	None	-39	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	413	6	5	10	-0.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133079	105554	0	None	-39	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	413	6	5	10	-0.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	76332919	105562	0	None	-316	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	323	3	5	10	-2.2	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133153	105562	0	None	-316	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	323	3	5	10	-2.2	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	76336525	105563	0	None	-158	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	337	4	5	10	-1.8	CCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1039/C3MD00364G
	CHEMBL3133154	105563	0	None	-158	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	337	4	5	10	-1.8	CCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1039/C3MD00364G
	44423821	141649	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	589	9	5	11	2.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(C(C)(C)C)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL388405	141649	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	589	9	5	11	2.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(C(C)(C)C)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	72141742	162014	2	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	302	5	1	7	0.0	O=C(CN1CCOC(Cn2cncn2)C1)Nc1cccnc1	10.1016/j.ejmech.2017.05.035
	CHEMBL4168653	162014	2	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	302	5	1	7	0.0	O=C(CN1CCOC(Cn2cncn2)C1)Nc1cccnc1	10.1016/j.ejmech.2017.05.035
	377	2707	47	None	-48	10	Human	6.8	pEC50	=	6.8	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061170a
	425	2707	47	None	-48	10	Human	6.8	pEC50	=	6.8	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061170a
	448222	2707	47	None	-48	10	Human	6.8	pEC50	=	6.8	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061170a
	CHEMBL464859	2707	47	None	-48	10	Human	6.8	pEC50	=	6.8	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061170a
	14157150	78804	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	324	3	4	9	-1.0	CCNC(=S)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	CHEMBL2113431	78804	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	324	3	4	9	-1.0	CCNC(=S)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	21893339	163349	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	366	5	3	7	1.6	CC(=O)Nc1ccc(-c2c(C#N)c(N)nc(SCC(N)=O)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4207286	163349	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	366	5	3	7	1.6	CC(=O)Nc1ccc(-c2c(C#N)c(N)nc(SCC(N)=O)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	137636099	155272	0	None	-173	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	535	6	3	12	1.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Br)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4059961	155272	0	None	-173	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	535	6	3	12	1.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Br)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	414	3318	29	None	-213	5	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	10.1021/jm061278q
	93205	3318	29	None	-213	5	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	10.1021/jm061278q
	CHEMBL139000	3318	29	None	-213	5	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	10.1021/jm061278q
	46885472	8234	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	381	4	2	8	3.5	CSc1nc(NC(=O)Nc2ccc(C)cc2)n2nc(-c3ccco3)nc2n1	10.1016/j.bmc.2010.02.039
	CHEMBL1092869	8234	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	381	4	2	8	3.5	CSc1nc(NC(=O)Nc2ccc(C)cc2)n2nc(-c3ccco3)nc2n1	10.1016/j.bmc.2010.02.039
	11395785	185922	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter methodAgonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter method	ChEMBL	410	5	4	9	0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.7b00457
	CHEMBL487754	185922	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter methodAgonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by forskolin addition measured after 10 mins by liquid scintillation counter method	ChEMBL	410	5	4	9	0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.7b00457
	168280775	190553	0	None	-1096	4	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	524	7	4	10	2.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(C(C)(C)C)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5188601	190553	0	None	-1096	4	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	524	7	4	10	2.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(C(C)(C)C)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	137643164	157544	0	None	5	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	552	12	5	11	2.6	O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1cccc(-c2cccs2)c1	10.1021/acs.jmedchem.8b00047
	CHEMBL4086624	157544	0	None	5	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	552	12	5	11	2.6	O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1cccc(-c2cccs2)c1	10.1021/acs.jmedchem.8b00047
	46885471	8233	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	367	4	2	8	3.1	CSc1nc(NC(=O)Nc2ccccc2)n2nc(-c3ccco3)nc2n1	10.1016/j.bmc.2010.02.039
	CHEMBL1092868	8233	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	367	4	2	8	3.1	CSc1nc(NC(=O)Nc2ccccc2)n2nc(-c3ccco3)nc2n1	10.1016/j.bmc.2010.02.039
	24827415	158867	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	ChEMBL	519	7	6	11	0.6	NNc1nc(OCCc2c[nH]c3cc(Br)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm701442d
	CHEMBL410104	158867	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	ChEMBL	519	7	6	11	0.6	NNc1nc(OCCc2c[nH]c3cc(Br)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm701442d
	16103168	82791	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	481	6	5	11	0.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc(C)s4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL218585	82791	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	481	6	5	11	0.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc(C)s4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	44423837	84811	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	581	10	5	11	1.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NCc5ccccc5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL225944	84811	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	581	10	5	11	1.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NCc5ccccc5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	44420921	84724	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	393	6	4	11	-0.3	Nc1nc(OCCc2cccs2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL225233	84724	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	393	6	4	11	-0.3	Nc1nc(OCCc2cccs2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	137649083	156753	0	None	7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	849	15	6	13	6.7	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3nc(Cl)nc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4077152	156753	0	None	7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	849	15	6	13	6.7	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3nc(Cl)nc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	145968949	164254	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	409	8	3	8	2.0	N#Cc1c(N)nc(SCC(=O)NCO)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4218613	164254	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	409	8	3	8	2.0	N#Cc1c(N)nc(SCC(=O)NCO)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	16202726	84274	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	552	6	5	10	0.7	Nc1nc(OCCc2c[nH]c3ccc(I)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL222748	84274	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	552	6	5	10	0.7	Nc1nc(OCCc2c[nH]c3ccc(I)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	11174953	16568	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	332	4	2	6	3.1	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccccc1	10.1021/jm049947s
	CHEMBL124345	16568	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	332	4	2	6	3.1	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccccc1	10.1021/jm049947s
	168283013	190271	0	None	-3715	4	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	516	8	4	10	1.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5184828	190271	0	None	-3715	4	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	516	8	4	10	1.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	137650899	156649	0	None	-35	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	413	6	3	13	0.0	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccco5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4076003	156649	0	None	-35	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	413	6	3	13	0.0	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccco5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	137657926	159209	0	None	-269	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	421	6	3	12	0.3	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4105164	159209	0	None	-269	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	421	6	3	12	0.3	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	76322076	105555	0	None	-39	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	489	7	5	10	1.0	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133080	105555	0	None	-39	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	489	7	5	10	1.0	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	76318403	105566	0	None	-39	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	363	4	5	10	-1.3	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCC4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133157	105566	0	None	-39	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	363	4	5	10	-1.3	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCC4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	57387337	75109	0	None	-6	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	326	3	4	9	-1.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(F)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042297	75109	0	None	-6	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	326	3	4	9	-1.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(F)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	16103185	165479	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	467	6	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4cccs4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL425643	165479	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	467	6	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4cccs4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	70689262	77608	0	None	-954	3	Human	5.7	pEC50	=	5.7	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	496	8	4	14	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](C)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL2096798	77608	0	None	-954	3	Human	5.7	pEC50	=	5.7	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	496	8	4	14	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](C)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	137656913	159094	0	None	-371	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATPAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATP	ChEMBL	389	4	3	9	0.5	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@@H]1O	10.1021/acs.jmedchem.7b01399
	CHEMBL4103712	159094	0	None	-371	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATPAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATP	ChEMBL	389	4	3	9	0.5	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@@H]1O	10.1021/acs.jmedchem.7b01399
	46885518	7701	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	427	5	2	8	4.5	Cc1ccc(NC(=O)Nc2nc(Oc3ccccc3)nc3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2010.02.039
	CHEMBL1089441	7701	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	427	5	2	8	4.5	Cc1ccc(NC(=O)Nc2nc(Oc3ccccc3)nc3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2010.02.039
	16109359	161217	0	None	-758	4	Human	5.7	pEC50	=	5.7	Functional	Activity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cellsActivity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cells	ChEMBL	924	21	6	14	4.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCNC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061279i
	CHEMBL414055	161217	0	None	-758	4	Human	5.7	pEC50	=	5.7	Functional	Activity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cellsActivity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cells	ChEMBL	924	21	6	14	4.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCNC(=O)CCCCCNC(=O)COc4ccc(/C=C/C5=[N+]6C(=Cc7ccc(-c8cccs8)n7[B-]6(F)F)C=C5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061279i
	16103167	82956	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	451	6	5	11	-0.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccco4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL219413	82956	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	451	6	5	11	-0.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccco4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	145977114	163208	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	367	6	2	7	2.3	CCOc1ccc(-c2c(C#N)c(N)nc(SCC(=O)NC)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4205729	163208	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	367	6	2	7	2.3	CCOc1ccc(-c2c(C#N)c(N)nc(SCC(=O)NC)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	137650221	156701	0	None	-56	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	463	6	3	13	1.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccs5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4076561	156701	0	None	-56	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	463	6	3	13	1.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccs5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	16202727	84301	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	460	6	5	10	0.8	Nc1nc(OCCc2c[nH]c3cc(Cl)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL222907	84301	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	460	6	5	10	0.8	Nc1nc(OCCc2c[nH]c3cc(Cl)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	16202725	84224	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	460	6	5	10	0.8	Nc1nc(OCCc2c[nH]c3ccc(Cl)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL222442	84224	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	460	6	5	10	0.8	Nc1nc(OCCc2c[nH]c3ccc(Cl)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	23757284	84691	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	438	4	5	10	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#C[C@@H](O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm061278q
	CHEMBL224874	84691	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	438	4	5	10	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#C[C@@H](O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm061278q
	118732974	117997	0	None	-47	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	373	5	3	12	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL3414940	117997	0	None	-47	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	373	5	3	12	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	137650918	156691	0	None	-6	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	671	14	6	13	3.4	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)cc1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4076495	156691	0	None	-6	4	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	671	14	6	13	3.4	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)cc1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	132991434	179368	0	None	-23	4	Human	6.7	pEC50	=	6.7	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	564	8	6	12	2.4	OC[C@H]1O[C@@H](n2cnc3c(Nc4ccc(CNC(=S)Nc5ccc(N=C=S)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b01561
	CHEMBL4746617	179368	0	None	-23	4	Human	6.7	pEC50	=	6.7	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	564	8	6	12	2.4	OC[C@H]1O[C@@H](n2cnc3c(Nc4ccc(CNC(=S)Nc5ccc(N=C=S)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b01561
	137651747	156927	0	None	-70	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	475	6	3	12	1.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(F)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4079433	156927	0	None	-70	4	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	475	6	3	12	1.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(F)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	16103178	160099	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	431	6	5	11	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc(C)o4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL411332	160099	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	431	6	5	11	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc(C)o4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	57384543	75120	0	None	-6	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	838	14	6	11	7.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042308	75120	0	None	-6	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	838	14	6	11	7.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)cc(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	449	2595	44	None	1	4	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2017.05.035
	453	2595	44	None	1	4	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2017.05.035
	6603931	2595	44	None	1	4	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2017.05.035
	CHEMBL273807	2595	44	None	1	4	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2017.05.035
	136015813	161802	4	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	322	6	2	7	2.6	CCCc1cc(O)nc(SC(C)C(=O)Nc2cc(C)no2)n1	10.1016/j.ejmech.2017.05.035
	CHEMBL4165135	161802	4	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	322	6	2	7	2.6	CCCc1cc(O)nc(SC(C)C(=O)Nc2cc(C)no2)n1	10.1016/j.ejmech.2017.05.035
	168273986	189573	0	None	-234422	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	505	6	4	10	1.6	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5174052	189573	0	None	-234422	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	505	6	4	10	1.6	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	137648928	156851	0	None	-97	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	549	6	3	12	1.0	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(I)c5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4078479	156851	0	None	-97	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	549	6	3	12	1.0	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(I)c5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	2844	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00828
	60961	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00828
	90	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00828
	CHEMBL477	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00828
	DB00640	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosineAgonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinosine	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00828
	137661132	158617	0	None	-316	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	491	6	3	12	1.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Cl)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4098377	158617	0	None	-316	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	491	6	3	12	1.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Cl)c5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	44423825	84962	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	577	11	5	12	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NCc5ccc(OC)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226304	84962	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	577	11	5	12	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NCc5ccc(OC)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	377	2707	47	None	-48	10	Human	5.6	pEC50	=	5.6	Functional	Receptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptorReceptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptor	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/s0960-894x(01)00347-x
	425	2707	47	None	-48	10	Human	5.6	pEC50	=	5.6	Functional	Receptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptorReceptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptor	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/s0960-894x(01)00347-x
	448222	2707	47	None	-48	10	Human	5.6	pEC50	=	5.6	Functional	Receptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptorReceptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptor	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/s0960-894x(01)00347-x
	CHEMBL464859	2707	47	None	-48	10	Human	5.6	pEC50	=	5.6	Functional	Receptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptorReceptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptor	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/s0960-894x(01)00347-x
	2844	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cellsAgonist activity at human adenosine A2B receptor expressed in CHO cells	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2011.02.053
	60961	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cellsAgonist activity at human adenosine A2B receptor expressed in CHO cells	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2011.02.053
	90	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cellsAgonist activity at human adenosine A2B receptor expressed in CHO cells	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2011.02.053
	CHEMBL477	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cellsAgonist activity at human adenosine A2B receptor expressed in CHO cells	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2011.02.053
	DB00640	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cellsAgonist activity at human adenosine A2B receptor expressed in CHO cells	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2011.02.053
	2844	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium level	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2010.05.056
	60961	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium level	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2010.05.056
	90	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium level	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2010.05.056
	CHEMBL477	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium level	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2010.05.056
	DB00640	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium levelAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium level	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2010.05.056
	2844	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	60961	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	90	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	CHEMBL477	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	DB00640	280	103	None	-31	5	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	168278159	189756	0	None	23	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assay	ChEMBL	839	15	5	15	6.6	Nc1sc(-c2ccc(-c3cn(CCCCCCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)nn3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL5177040	189756	0	None	23	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assay	ChEMBL	839	15	5	15	6.6	Nc1sc(-c2ccc(-c3cn(CCCCCCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)nn3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	377	2707	47	None	-48	10	Human	6.6	pEC50	=	6.6	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	425	2707	47	None	-48	10	Human	6.6	pEC50	=	6.6	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	448222	2707	47	None	-48	10	Human	6.6	pEC50	=	6.6	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	CHEMBL464859	2707	47	None	-48	10	Human	6.6	pEC50	=	6.6	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	76325694	105568	0	None	-39	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	391	4	5	10	-0.5	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCCC4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133159	105568	0	None	-39	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	391	4	5	10	-0.5	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCCC4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	57388055	75118	0	None	-40	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	622	12	6	11	3.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(N)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042306	75118	0	None	-40	4	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	622	12	6	11	3.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(N)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	137641990	157522	0	None	-48	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	447	6	3	13	0.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccco5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4086325	157522	0	None	-48	4	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	447	6	3	13	0.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccco5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	16204411	84309	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	376	6	5	10	-1.0	Nc1nc(OCCc2cc[nH]c2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL222945	84309	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	376	6	5	10	-1.0	Nc1nc(OCCc2cc[nH]c2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	168290340	191286	0	None	-7943	3	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	475	7	4	10	1.6	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5199871	191286	0	None	-7943	3	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	475	7	4	10	1.6	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	16103165	82955	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	447	6	5	11	-0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc(C)s4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL219411	82955	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	447	6	5	11	-0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc(C)s4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	137639588	156330	0	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccccc2C(=O)NCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4072009	156330	0	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccccc2C(=O)NCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	24827289	166858	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	ChEMBL	613	9	6	12	1.7	O=C(NNc1nc(OCCc2c[nH]c3cc(Br)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccco1	10.1021/jm701442d
	CHEMBL429684	166858	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	ChEMBL	613	9	6	12	1.7	O=C(NNc1nc(OCCc2c[nH]c3cc(Br)ccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccco1	10.1021/jm701442d
	3044933	16291	4	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	322	4	4	9	-1.4	CCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	CHEMBL1235128	16291	4	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	322	4	4	9	-1.4	CCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	57388056	75119	0	None	-9	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	685	12	5	10	4.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(Br)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042307	75119	0	None	-9	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	685	12	5	10	4.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(Br)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	16203429	84369	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	426	6	5	10	0.1	Nc1nc(OCCc2c[nH]c3ccccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL223366	84369	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	426	6	5	10	0.1	Nc1nc(OCCc2c[nH]c3ccccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	377	2707	47	None	-48	10	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1039/C3MD00364G
	425	2707	47	None	-48	10	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1039/C3MD00364G
	448222	2707	47	None	-48	10	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1039/C3MD00364G
	CHEMBL464859	2707	47	None	-48	10	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1039/C3MD00364G
	44423815	84946	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	659	9	5	11	1.9	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(I)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226242	84946	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	659	9	5	11	1.9	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(I)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	44423822	84961	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	618	10	5	13	1.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(N6CCOCC6)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226303	84961	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	618	10	5	13	1.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(N6CCOCC6)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	70689262	77608	0	None	-954	3	Human	5.5	pEC50	=	5.5	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	496	8	4	14	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](C)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL2096798	77608	0	None	-954	3	Human	5.5	pEC50	=	5.5	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	496	8	4	14	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](C)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	71456259	78808	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	376	4	4	9	-0.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NCCC(F)(F)F)[C@@H](O)[C@H]1O	10.1021/jm9804984
	CHEMBL2113435	78808	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	376	4	4	9	-0.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NCCC(F)(F)F)[C@@H](O)[C@H]1O	10.1021/jm9804984
	44423838	141733	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	573	9	5	11	1.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NC5CCCCC5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL388505	141733	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	573	9	5	11	1.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NC5CCCCC5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	11717831	578	39	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	10.1016/j.ejmech.2018.02.081
	3289	578	39	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	10.1016/j.ejmech.2018.02.081
	CHEMBL4202825	578	39	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	10.1016/j.ejmech.2018.02.081
	123683	3060	58	None	-1258	5	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1039/C3MD00364G
	422	3060	58	None	-1258	5	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1039/C3MD00364G
	CHEMBL119709	3060	58	None	-1258	5	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1039/C3MD00364G
	DB05511	3060	58	None	-1258	5	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1039/C3MD00364G
	377	2707	47	None	-48	10	Human	5.5	pEC50	=	5.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm9804984
	425	2707	47	None	-48	10	Human	5.5	pEC50	=	5.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm9804984
	448222	2707	47	None	-48	10	Human	5.5	pEC50	=	5.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm9804984
	CHEMBL464859	2707	47	None	-48	10	Human	5.5	pEC50	=	5.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm9804984
	44423826	84964	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	539	9	5	11	1.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NC5CCCCC5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226307	84964	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	539	9	5	11	1.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)NC5CCCCC5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	118732979	118002	0	None	-426	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	437	5	3	13	0.0	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CCCO5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414945	118002	0	None	-426	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	437	5	3	13	0.0	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CCCO5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	44423823	141651	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	534	9	5	12	0.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccncc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL388406	141651	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	534	9	5	12	0.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccncc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	44423817	84947	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	563	10	5	12	1.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(OC)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226243	84947	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	563	10	5	12	1.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(OC)cc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	10688700	76564	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	342	4	4	9	-1.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NCCCl)[C@@H](O)[C@H]1O	10.1021/jm9804984
	CHEMBL2070399	76564	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	342	4	4	9	-1.6	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NCCCl)[C@@H](O)[C@H]1O	10.1021/jm9804984
	16203668	95880	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	454	8	5	10	1.0	CCNc1nc(OCCc2c[nH]c3ccccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL261515	95880	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	454	8	5	10	1.0	CCNc1nc(OCCc2c[nH]c3ccccc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	377	2707	47	None	-48	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	425	2707	47	None	-48	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	448222	2707	47	None	-48	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	CHEMBL464859	2707	47	None	-48	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm4011669
	10449535	76566	0	None	-2187	3	Human	4.5	pEC50	=	4.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	334	3	4	9	-1.3	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCC2)[C@@H](O)[C@H]1O	10.1021/jm9804984
	CHEMBL2070507	76566	0	None	-2187	3	Human	4.5	pEC50	=	4.5	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	334	3	4	9	-1.3	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCC2)[C@@H](O)[C@H]1O	10.1021/jm9804984
	377	2707	47	None	-48	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	425	2707	47	None	-48	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	448222	2707	47	None	-48	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	CHEMBL464859	2707	47	None	-48	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	145967103	163574	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	376	6	2	7	3.5	CCOc1ccc(-c2c(C#N)c(N)nc(SCc3ccn[nH]3)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4210096	163574	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	376	6	2	7	3.5	CCOc1ccc(-c2c(C#N)c(N)nc(SCc3ccn[nH]3)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	127043828	140581	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Antagonist activity at human adenosine receptor A2b expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation measured as NECA EC50 at 2 uM incubated for 15 mins in presence of [3H]cAMP by liquid scintillation counting (Rvb = 73 nM)Antagonist activity at human adenosine receptor A2b expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation measured as NECA EC50 at 2 uM incubated for 15 mins in presence of [3H]cAMP by liquid scintillation counting (Rvb = 73 nM)	ChEMBL	538	15	0	9	4.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN(CC)CC)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	CHEMBL3827331	140581	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Antagonist activity at human adenosine receptor A2b expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation measured as NECA EC50 at 2 uM incubated for 15 mins in presence of [3H]cAMP by liquid scintillation counting (Rvb = 73 nM)Antagonist activity at human adenosine receptor A2b expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation measured as NECA EC50 at 2 uM incubated for 15 mins in presence of [3H]cAMP by liquid scintillation counting (Rvb = 73 nM)	ChEMBL	538	15	0	9	4.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN(CC)CC)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	15729982	7803	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	245	2	1	8	0.4	CN(C)c1nc(N)n2nc(-c3ccco3)nc2n1	10.1016/j.bmc.2010.02.039
	CHEMBL1090124	7803	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	245	2	1	8	0.4	CN(C)c1nc(N)n2nc(-c3ccco3)nc2n1	10.1016/j.bmc.2010.02.039
	11256992	17747	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	362	5	2	7	3.1	COc1cccc(-c2c(C#N)c(N)nc(SCc3ncc[nH]3)c2C#N)c1	10.1021/jm049947s
	CHEMBL125979	17747	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	362	5	2	7	3.1	COc1cccc(-c2c(C#N)c(N)nc(SCc3ncc[nH]3)c2C#N)c1	10.1021/jm049947s
	51112335	161673	6	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	311	4	2	6	2.4	Cc1cc(NC(=O)CNc2ccc3c(c2)OC(F)(F)O3)on1	10.1016/j.ejmech.2017.05.035
	CHEMBL4163380	161673	6	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	311	4	2	6	2.4	Cc1cc(NC(=O)CNc2ccc3c(c2)OC(F)(F)O3)on1	10.1016/j.ejmech.2017.05.035
	56783276	161909	4	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	319	6	1	7	1.6	CC(C)c1noc(OCC(=O)NCc2ccc3c(c2)OCO3)n1	10.1016/j.ejmech.2017.05.035
	CHEMBL4167064	161909	4	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	319	6	1	7	1.6	CC(C)c1noc(OCC(=O)NCc2ccc3c(c2)OCO3)n1	10.1016/j.ejmech.2017.05.035
	16103186	158290	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	481	6	5	11	0.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4sccc4C)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL409483	158290	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	481	6	5	11	0.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4sccc4C)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	3071852	8297	5	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	294	3	1	8	2.2	Nc1nc(Oc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.bmc.2010.02.039
	CHEMBL1093313	8297	5	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	294	3	1	8	2.2	Nc1nc(Oc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.bmc.2010.02.039
	145965011	163637	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	470	8	1	8	4.9	COC(=O)c1cccc(CSc2nc(N)c(C#N)c(-c3ccc(OCC4CC4)cc3)c2C#N)c1	10.1016/j.ejmech.2018.02.081
	CHEMBL4210852	163637	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	470	8	1	8	4.9	COC(=O)c1cccc(CSc2nc(N)c(C#N)c(-c3ccc(OCC4CC4)cc3)c2C#N)c1	10.1016/j.ejmech.2018.02.081
	118732971	117993	0	None	-147	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	333	3	3	12	-1.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414936	117993	0	None	-147	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	333	3	3	12	-1.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	131432	136520	11	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	387	6	4	10	-0.4	Nc1nc(OCCc2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL374685	136520	11	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	387	6	4	10	-0.4	Nc1nc(OCCc2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	137661505	158937	0	None	2	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2cccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4101850	158937	0	None	2	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2cccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	44423820	141555	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	577	9	5	13	1.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc6c(c5)OCO6)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL388194	141555	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	577	9	5	13	1.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc6c(c5)OCO6)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	118732973	117996	0	None	-446	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	381	4	3	12	-0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414939	117996	0	None	-446	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	381	4	3	12	-0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	57387825	75112	0	None	-8	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	505	7	5	10	0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(Br)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042300	75112	0	None	-8	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	505	7	5	10	0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(Br)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	16103187	82870	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	450	6	6	10	-0.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc[nH]4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL218989	82870	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	450	6	6	10	-0.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc[nH]4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	44423828	84963	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	597	10	5	12	2.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(OC)cc5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226305	84963	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	597	10	5	12	2.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(OC)cc5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	377	2707	47	None	-48	10	Human	5.4	pEC50	=	5.4	Functional	Activity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cellsActivity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061279i
	425	2707	47	None	-48	10	Human	5.4	pEC50	=	5.4	Functional	Activity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cellsActivity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061279i
	448222	2707	47	None	-48	10	Human	5.4	pEC50	=	5.4	Functional	Activity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cellsActivity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061279i
	CHEMBL464859	2707	47	None	-48	10	Human	5.4	pEC50	=	5.4	Functional	Activity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cellsActivity at human adenosine A2B receptor assessed as stimulation of [3H]cAMP accumulation in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm061279i
	16203540	84189	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	504	6	5	10	0.9	Nc1nc(OCCc2c[nH]c3ccc(Br)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL222194	84189	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	504	6	5	10	0.9	Nc1nc(OCCc2c[nH]c3ccc(Br)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	16103177	82942	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	495	6	5	11	-0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc(Br)o4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL219361	82942	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	495	6	5	11	-0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccc(Br)o4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	21128750	199968	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	322	3	4	9	-1.4	CC(C)NC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	CHEMBL606095	199968	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	322	3	4	9	-1.4	CC(C)NC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	137658761	158624	0	None	-66	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATPAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATP	ChEMBL	413	4	3	8	2.2	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(Nc4ccc(Cl)cc4F)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.7b01399
	CHEMBL4098408	158624	0	None	-66	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATPAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity in presence of [alpha-31P]ATP	ChEMBL	413	4	3	8	2.2	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(Nc4ccc(Cl)cc4F)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.7b01399
	145975919	163302	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	353	6	2	7	2.1	CCOc1ccc(-c2c(C#N)c(N)nc(SCC(N)=O)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4206762	163302	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	353	6	2	7	2.1	CCOc1ccc(-c2c(C#N)c(N)nc(SCC(N)=O)c2C#N)cc1	10.1016/j.ejmech.2018.02.081
	377	2707	47	None	-48	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assayAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2009.11.131
	425	2707	47	None	-48	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assayAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2009.11.131
	448222	2707	47	None	-48	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assayAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2009.11.131
	CHEMBL464859	2707	47	None	-48	10	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assayAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2009.11.131
	168269860	189373	0	None	-17782	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	512	9	4	11	1.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(OC)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5170857	189373	0	None	-17782	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	512	9	4	11	1.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4cccc(OC)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	118734376	118120	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	602	10	4	12	1.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(N4CCN(c5ccc(OCCCc6ccccc6)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	CHEMBL3416810	118120	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	602	10	4	12	1.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(N4CCN(c5ccc(OCCCc6ccccc6)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	3086599	889	35	None	-1	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	10.1039/C3MD00364G
	375	889	35	None	-1	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	10.1039/C3MD00364G
	424	889	35	None	-1	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	10.1039/C3MD00364G
	CHEMBL331372	889	35	None	-1	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	10.1039/C3MD00364G
	76336527	105570	0	None	-630	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	433	5	5	10	0.0	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(Cl)c4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133161	105570	0	None	-630	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	433	5	5	10	0.0	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(Cl)c4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	71657835	159178	2	None	-1	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL4104819	159178	2	None	-1	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	377	2707	47	None	-48	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	425	2707	47	None	-48	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	448222	2707	47	None	-48	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	CHEMBL464859	2707	47	None	-48	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c00320
	57384544	75121	0	None	-57	4	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	854	14	7	12	7.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042309	75121	0	None	-57	4	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	854	14	7	12	7.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	137647420	157147	0	None	-194	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	501	6	3	12	1.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Br)c5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4081876	157147	0	None	-194	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	501	6	3	12	1.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Br)c5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	44423827	84974	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	567	9	5	11	2.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccccc5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226356	84974	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	567	9	5	11	2.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccccc5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	377	2707	47	None	-48	10	Human	7.4	pEC50	=	7.4	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.6b01561
	425	2707	47	None	-48	10	Human	7.4	pEC50	=	7.4	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.6b01561
	448222	2707	47	None	-48	10	Human	7.4	pEC50	=	7.4	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.6b01561
	CHEMBL464859	2707	47	None	-48	10	Human	7.4	pEC50	=	7.4	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.6b01561
	46885404	7926	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	396	6	1	9	2.7	COc1ccc(CC(=O)Nc2nc(SC)nc3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2010.02.039
	CHEMBL1090806	7926	0	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	396	6	1	9	2.7	COc1ccc(CC(=O)Nc2nc(SC)nc3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2010.02.039
	168293442	191527	0	None	-17782	4	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	546	7	4	10	1.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5203632	191527	0	None	-17782	4	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	546	7	4	10	1.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Br)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	168297905	191823	0	None	-2041	4	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	516	8	4	10	1.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5208245	191823	0	None	-2041	4	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	516	8	4	10	1.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4OCc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	377	2707	47	None	-48	10	Human	6.4	pEC50	=	6.4	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	425	2707	47	None	-48	10	Human	6.4	pEC50	=	6.4	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	448222	2707	47	None	-48	10	Human	6.4	pEC50	=	6.4	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	CHEMBL464859	2707	47	None	-48	10	Human	6.4	pEC50	=	6.4	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	137646655	157072	0	None	-6	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	711	13	6	12	4.8	Nc1cc(-c2cccc(C(F)(F)F)c2)c(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)s1	10.1021/acs.jmedchem.8b00047
	CHEMBL4081224	157072	0	None	-6	4	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	711	13	6	12	4.8	Nc1cc(-c2cccc(C(F)(F)F)c2)c(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)s1	10.1021/acs.jmedchem.8b00047
	44423818	84948	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	593	11	5	13	1.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(OC)c(OC)c5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226244	84948	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	593	11	5	13	1.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccc(OC)c(OC)c5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	16103184	82869	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	467	6	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccsc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL218988	82869	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	467	6	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccsc4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	3042985	78807	1	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	310	3	4	10	-2.3	CONC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	CHEMBL2113434	78807	1	None	-	1	Human	4.4	pEC50	=	4.4	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	310	3	4	10	-2.3	CONC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	98567	191175	18	None	-1174	3	Human	4.4	pEC50	=	4.4	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	294	2	4	9	-2.2	CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	CHEMBL519809	191175	18	None	-1174	3	Human	4.4	pEC50	=	4.4	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	294	2	4	9	-2.2	CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9804984
	16365293	162336	4	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	344	5	2	8	0.6	CC(OC(=O)c1nccnc1N)C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.ejmech.2017.05.035
	CHEMBL4173768	162336	4	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	344	5	2	8	0.6	CC(OC(=O)c1nccnc1N)C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.ejmech.2017.05.035
	137652475	156591	0	None	-6	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	829	16	6	13	6.5	Nc1sc(-c2ccc(C(=O)NCCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4075186	156591	0	None	-6	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	829	16	6	13	6.5	Nc1sc(-c2ccc(C(=O)NCCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	10256007	122401	0	None	-47	2	Human	5.3	pEC50	=	5.3	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	516	8	5	14	0.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Cl)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL360646	122401	0	None	-47	2	Human	5.3	pEC50	=	5.3	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	516	8	5	14	0.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Cl)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	10388920	69466	7	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assayAgonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assay	ChEMBL	447	7	4	9	1.7	OC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acsmedchemlett.0c00509
	CHEMBL193692	69466	7	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assayAgonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assay	ChEMBL	447	7	4	9	1.7	OC[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acsmedchemlett.0c00509
	168285984	191136	0	None	-5248	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	461	6	4	10	1.5	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5197358	191136	0	None	-5248	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	461	6	4	10	1.5	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	76336526	105564	0	None	-501	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	351	5	5	10	-1.4	CCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1039/C3MD00364G
	CHEMBL3133155	105564	0	None	-501	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	351	5	5	10	-1.4	CCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O	10.1039/C3MD00364G
	145972065	163979	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	403	7	2	8	3.3	N#Cc1c(N)nc(SCc2ncn[nH]2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4215091	163979	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	403	7	2	8	3.3	N#Cc1c(N)nc(SCc2ncn[nH]2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	9869857	66481	7	None	-213	5	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assayAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1016/j.bmcl.2009.11.131
	CHEMBL186113	66481	7	None	-213	5	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assayAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1016/j.bmcl.2009.11.131
	168297825	191675	0	None	-8317	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	461	6	4	10	1.5	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5205907	191675	0	None	-8317	4	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	461	6	4	10	1.5	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	168286257	190990	0	None	6	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	863	14	6	13	6.3	Nc1sc(-c2ccc(C(=O)NCCc3ccc(CCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL5195260	190990	0	None	6	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	863	14	6	13	6.3	Nc1sc(-c2ccc(C(=O)NCCc3ccc(CCNc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	2844	280	103	None	-31	5	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	60961	280	103	None	-31	5	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	90	280	103	None	-31	5	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	CHEMBL477	280	103	None	-31	5	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	DB00640	280	103	None	-31	5	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	168293183	191518	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	767	16	6	13	4.7	Nc1sc(CCC(=O)NCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL5203535	191518	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	767	16	6	13	4.7	Nc1sc(CCC(=O)NCCCCCCNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	137642153	157811	0	None	-35	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	429	6	3	13	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccs5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4089741	157811	0	None	-35	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	429	6	3	13	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccs5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	44423819	84949	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	593	11	5	13	1.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5cc(OC)cc(OC)c5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226245	84949	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	593	11	5	13	1.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5cc(OC)cc(OC)c5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	118732980	118003	0	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	461	5	3	12	1.4	CCn1nnc([C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414946	118003	0	None	-63	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	461	5	3	12	1.4	CCn1nnc([C@H]2O[C@@H](n3cnc4c(Nc5ccc(Cl)cc5F)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	10403711	95873	27	None	-501	3	Human	5.3	pEC50	=	5.3	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	320	3	4	9	-1.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O	10.1021/jm9804984
	CHEMBL261482	95873	27	None	-501	3	Human	5.3	pEC50	=	5.3	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	320	3	4	9	-1.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O	10.1021/jm9804984
	44420926	137523	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	350	4	6	9	-2.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC(=N)N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061278q
	CHEMBL376542	137523	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	350	4	6	9	-2.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC(=N)N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061278q
	215610	76567	2	None	-239	2	Human	4.3	pEC50	=	4.3	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	348	3	4	9	-0.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCCC2)[C@@H](O)[C@H]1O	10.1021/jm9804984
	CHEMBL2070508	76567	2	None	-239	2	Human	4.3	pEC50	=	4.3	Functional	Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAEffective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNA	ChEMBL	348	3	4	9	-0.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCCC2)[C@@H](O)[C@H]1O	10.1021/jm9804984
	56627882	117994	0	None	-141	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	367	3	3	12	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414937	117994	0	None	-141	4	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	367	3	3	12	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	11157262	123110	0	None	-537	3	Human	6.3	pEC50	=	6.3	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	560	8	5	14	0.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Br)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL361925	123110	0	None	-537	3	Human	6.3	pEC50	=	6.3	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	560	8	5	14	0.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Br)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	137638080	156281	0	None	-269	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	457	6	3	12	1.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Cl)c5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4071338	156281	0	None	-269	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	457	6	3	12	1.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5cccc(Cl)c5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	168293564	191549	0	None	45	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	849	13	6	13	6.8	Nc1sc(-c2ccc(C(=O)NCCCc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL5203917	191549	0	None	45	4	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	849	13	6	13	6.8	Nc1sc(-c2ccc(C(=O)NCCCc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	137653409	158479	0	None	-1	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	567	12	6	12	2.2	Nc1ccc(-c2cccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2)s1	10.1021/acs.jmedchem.8b00047
	CHEMBL4096796	158479	0	None	-1	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	567	12	6	12	2.2	Nc1ccc(-c2cccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2)s1	10.1021/acs.jmedchem.8b00047
	168288912	191022	0	None	-4897	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	502	7	4	10	1.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5195714	191022	0	None	-4897	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	502	7	4	10	1.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4Cl)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	16103169	82244	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	481	7	5	11	-0.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)Cc4cccs4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL217952	82244	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	481	7	5	11	-0.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)Cc4cccs4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	57384288	75114	0	None	-426	4	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	674	9	7	12	3.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042302	75114	0	None	-426	4	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	674	9	7	12	3.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	118719026	114923	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	582	13	4	8	2.1	CC(C)(C)OC(=O)C1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1	10.1021/jm4011669
	CHEMBL3350613	114923	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	ChEMBL	582	13	4	8	2.1	CC(C)(C)OC(=O)C1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1	10.1021/jm4011669
	137650461	156702	0	None	-1	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	857	16	6	13	6.4	CC(=O)Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4076565	156702	0	None	-1	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	857	16	6	13	6.4	CC(=O)Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	137634444	155610	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	801	14	6	13	5.7	Nc1sc(-c2ccc(C(=O)NCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4063841	155610	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	801	14	6	13	5.7	Nc1sc(-c2ccc(C(=O)NCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	377	2707	47	None	-48	10	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	425	2707	47	None	-48	10	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	448222	2707	47	None	-48	10	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	CHEMBL464859	2707	47	None	-48	10	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.2c01414
	137642036	157595	0	None	-177	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	387	6	3	12	-0.4	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL4087306	157595	0	None	-177	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	387	6	3	12	-0.4	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	57387822	75124	0	None	-3	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	840	13	7	12	6.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042312	75124	0	None	-3	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	840	13	7	12	6.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(NCCc4ccc(NC(=O)c5cc(C(C)(C)C)c(O)c(C(C)(C)C)c5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	118732974	117997	0	None	-47	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	373	5	3	12	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414940	117997	0	None	-47	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	373	5	3	12	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)ncnc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	118732975	117998	0	None	-173	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	407	5	3	12	0.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	CHEMBL3414941	117998	0	None	-173	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assayAgonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as stimulation of adenylyl cyclase activity by [alpha-32P]ATP assay	ChEMBL	407	5	3	12	0.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NC5CC5)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.7b00291
	10436433	130838	0	None	-478	2	Human	6.2	pEC50	=	6.2	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	512	9	5	15	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL368880	130838	0	None	-478	2	Human	6.2	pEC50	=	6.2	Functional	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorPotency against cAMP formation in CHO cells expressing recombinant human A2B receptor	ChEMBL	512	9	5	15	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	44423811	84933	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	533	9	5	11	1.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccccc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	CHEMBL226193	84933	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	533	9	5	11	1.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(Nc4ccc(OCC(=O)Nc5ccccc5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.01.055
	162645916	178906	0	None	-9	4	Human	6.2	pEC50	=	6.2	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	414	6	4	11	0.8	OC[C@H]1O[C@@H](n2cnc3c(Nc4ccc(CN=C=S)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b01561
	CHEMBL4741079	178906	0	None	-9	4	Human	6.2	pEC50	=	6.2	Functional	Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assayIrreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation incubated for 30 mins by LANCE cAMP detection assay	ChEMBL	414	6	4	11	0.8	OC[C@H]1O[C@@H](n2cnc3c(Nc4ccc(CN=C=S)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b01561
	118734347	118093	0	None	-45	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	637	8	5	12	0.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCN4CCN(c5ccc(I)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	CHEMBL3416782	118093	0	None	-45	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	637	8	5	12	0.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCN4CCN(c5ccc(I)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	57384289	75115	0	None	-112	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	630	13	6	13	2.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)CCCC[C@H]5CCSS5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	CHEMBL2042303	75115	0	None	-112	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 minsAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins	ChEMBL	630	13	6	13	2.5	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(NC(=O)CCCC[C@H]5CCSS5)cc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm300206u
	137646828	157450	0	None	-1	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	856	16	6	13	6.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCCCNC(=O)c4ccc(-c5sc(N)c(C(=O)c6ccccc6)c5-c5cccc(C(F)(F)F)c5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.8b00047
	CHEMBL4085418	157450	0	None	-1	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	856	16	6	13	6.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCCCNC(=O)c4ccc(-c5sc(N)c(C(=O)c6ccccc6)c5-c5cccc(C(F)(F)F)c5)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.8b00047
	16203539	135813	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	444	6	5	10	0.3	Nc1nc(OCCc2c[nH]c3ccc(F)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL373478	135813	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	444	6	5	10	0.3	Nc1nc(OCCc2c[nH]c3ccc(F)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	76329265	105567	0	None	-50	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	377	4	5	10	-0.9	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	CHEMBL3133158	105567	0	None	-50	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assayAgonist activity at human adenosine A2B receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay	ChEMBL	377	4	5	10	-0.9	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(N)nc32)[C@H](O)[C@@H]1O	10.1039/C3MD00364G
	168283120	190457	0	None	-60255	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	498	8	4	11	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(OC)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5187330	190457	0	None	-60255	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	498	8	4	11	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(OC)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	168287894	190747	0	None	-776	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	502	7	4	10	1.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(Cl)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5191989	190747	0	None	-776	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	502	7	4	10	1.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccc(Cl)cc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	71657835	159178	2	None	-1	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL4104819	159178	2	None	-1	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayAgonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.2c00320
	16103176	82796	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	417	6	5	11	-1.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccco4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	CHEMBL218596	82796	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsActivity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levels	ChEMBL	417	6	5	11	-1.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NNC(=O)c4ccco4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm061170a
	118732982	118005	0	None	-91	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	583	6	3	12	1.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccccc5I)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	CHEMBL3414948	118005	0	None	-91	4	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor transfected in CHO cells assessed as induction of adenylyl cyclase activity	ChEMBL	583	6	3	12	1.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(NCc5ccccc5I)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1021/acs.jmedchem.5b00074
	145976032	163024	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	402	7	2	7	3.9	N#Cc1c(N)nc(SCc2ccn[nH]2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4203420	163024	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	402	7	2	7	3.9	N#Cc1c(N)nc(SCc2ccn[nH]2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	155535452	171514	0	None	-14	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assayAgonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assay	ChEMBL	286	4	2	7	1.8	N#Cc1c(N)nc(SCCO)c(C#N)c1-c1ccoc1	10.1021/acs.jmedchem.9b00106
	CHEMBL4472401	171514	0	None	-14	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assayAgonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assay	ChEMBL	286	4	2	7	1.8	N#Cc1c(N)nc(SCCO)c(C#N)c1-c1ccoc1	10.1021/acs.jmedchem.9b00106
	118734374	118117	0	None	-22	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	642	8	4	12	2.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(N4CCN(c5ccc(OCc6ccc(C(F)(F)F)cc6)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	CHEMBL3416808	118117	0	None	-22	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	642	8	4	12	2.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(N4CCN(c5ccc(OCc6ccc(C(F)(F)F)cc6)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	69961639	175149	0	None	-8	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assayAgonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assay	ChEMBL	302	4	2	7	2.2	N#Cc1c(N)nc(SCCO)c(C#N)c1-c1cccs1	10.1021/acs.jmedchem.9b00106
	CHEMBL4582726	175149	0	None	-8	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assayAgonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assay	ChEMBL	302	4	2	7	2.2	N#Cc1c(N)nc(SCCO)c(C#N)c1-c1cccs1	10.1021/acs.jmedchem.9b00106
	46865897	7700	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	413	5	2	8	4.2	O=C(Nc1ccccc1)Nc1nc(Oc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.bmc.2010.02.039
	CHEMBL1089440	7700	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	413	5	2	8	4.2	O=C(Nc1ccccc1)Nc1nc(Oc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.bmc.2010.02.039
	16202841	84239	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	442	6	6	11	-0.2	Nc1nc(OCCc2c[nH]c3ccc(O)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	CHEMBL222500	84239	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	442	6	6	11	-0.2	Nc1nc(OCCc2c[nH]c3ccc(O)cc23)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm061278q
	11164346	15945	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	362	5	2	7	3.1	COc1ccc(-c2c(C#N)c(N)nc(SCc3ncc[nH]3)c2C#N)cc1	10.1021/jm049947s
	CHEMBL122396	15945	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonistic activity against human adenosine A2B receptor expressed in CHO cellsAgonistic activity against human adenosine A2B receptor expressed in CHO cells	ChEMBL	362	5	2	7	3.1	COc1ccc(-c2c(C#N)c(N)nc(SCc3ncc[nH]3)c2C#N)cc1	10.1021/jm049947s
	145973077	164114	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	402	7	2	7	3.9	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	CHEMBL4216880	164114	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	402	7	2	7	3.9	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccc(OCC2CC2)cc1	10.1016/j.ejmech.2018.02.081
	137641858	157750	0	None	1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	696	13	5	11	5.3	O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccc(-c2sccc2-c2cccc(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4089092	157750	0	None	1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	696	13	5	11	5.3	O=C(NCCCCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)c1ccc(-c2sccc2-c2cccc(C(F)(F)F)c2)cc1	10.1021/acs.jmedchem.8b00047
	168269866	189385	0	None	-3090	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	468	7	4	10	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5171042	189385	0	None	-3090	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	468	7	4	10	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	118734372	118115	0	None	-17	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	608	8	4	12	1.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(N4CCN(c5ccc(OCc6ccc(Cl)cc6)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	CHEMBL3416806	118115	0	None	-17	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	608	8	4	12	1.7	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(N4CCN(c5ccc(OCc6ccc(Cl)cc6)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	118734345	118091	0	None	-301	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	545	8	5	12	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCN4CCN(c5ccc(Cl)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	CHEMBL3416780	118091	0	None	-301	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	545	8	5	12	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCN4CCN(c5ccc(Cl)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	118734346	118092	0	None	-218	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	589	8	5	12	0.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCN4CCN(c5ccc(Br)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	CHEMBL3416781	118092	0	None	-218	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting method	ChEMBL	589	8	5	12	0.2	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(NCCN4CCN(c5ccc(Br)cc5)CC4)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00215
	89534951	163868	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	393	7	2	7	2.7	CNC(=O)CSc1nc(N)c(C#N)c(-c2ccc(OCC3CC3)cc2)c1C#N	10.1016/j.ejmech.2018.02.081
	CHEMBL4213681	163868	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assayAgonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as induction of cAMP accumulation by AlphaScreen assay	ChEMBL	393	7	2	7	2.7	CNC(=O)CSc1nc(N)c(C#N)c(-c2ccc(OCC3CC3)cc2)c1C#N	10.1016/j.ejmech.2018.02.081
	377	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assayAgonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acsmedchemlett.0c00509
	425	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assayAgonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acsmedchemlett.0c00509
	448222	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assayAgonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acsmedchemlett.0c00509
	CHEMBL464859	2707	47	None	-48	10	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assayAgonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of rolipram and adenosine deaminase followed by compound addition and measured after 20 mins by alphascreen cAMP assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acsmedchemlett.0c00509
	168272212	189827	0	None	-2	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	518	10	5	10	1.9	O=C(NCCCCc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)c1ccccc1	10.1021/acs.jmedchem.2c00320
	CHEMBL5178142	189827	0	None	-2	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assayAgonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by LANCE cAMP assay	ChEMBL	518	10	5	10	1.9	O=C(NCCCCc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)c1ccccc1	10.1021/acs.jmedchem.2c00320
	71657835	159178	2	None	-1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	CHEMBL4104819	159178	2	None	-1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	815	15	6	13	6.1	Nc1sc(-c2ccc(C(=O)NCCCCCCNc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)c(-c2cccc(C(F)(F)F)c2)c1C(=O)c1ccccc1	10.1021/acs.jmedchem.8b00047
	9869857	66481	7	None	-213	5	Human	6.0	pEC50	=	6.0	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL186113	66481	7	None	-213	5	Human	6.0	pEC50	=	6.0	Functional	Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaRelative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aorta	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	24827290	155802	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	ChEMBL	707	11	5	12	3.0	O=C(COc1ccc(Nc2nc(OCCc3c[nH]c4cc(Br)ccc34)nc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)N1CCCC1	10.1021/jm701442d
	CHEMBL406594	155802	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	ChEMBL	707	11	5	12	3.0	O=C(COc1ccc(Nc2nc(OCCc3c[nH]c4cc(Br)ccc34)nc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)N1CCCC1	10.1021/jm701442d
	137634052	156092	0	None	6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	830	15	7	14	5.7	Nc1nc(NCCCCCCNC(=O)c2ccc(-c3sc(N)c(C(=O)c4ccccc4)c3-c3cccc(C(F)(F)F)c3)cc2)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1	10.1021/acs.jmedchem.8b00047
	CHEMBL4069296	156092	0	None	6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assayAgonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mins followed by forskolin addition measured after 30 mins by Alphascreen assay	ChEMBL	830	15	7	14	5.7	Nc1nc(NCCCCCCNC(=O)c2ccc(-c3sc(N)c(C(=O)c4ccccc4)c3-c3cccc(C(F)(F)F)c3)cc2)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1	10.1021/acs.jmedchem.8b00047
	168276883	189596	0	None	-1862	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	502	7	4	10	1.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	CHEMBL5174429	189596	0	None	-1862	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assayAgonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay	ChEMBL	502	7	4	10	1.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCC[C@H]4Oc4cccc(Cl)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.2c01414
	155541051	172387	0	None	-251	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assayAgonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assay	ChEMBL	406	5	1	8	4.2	COC(=O)c1cccc(CSc2nc(N)c(C#N)c(-c3cccs3)c2C#N)c1	10.1021/acs.jmedchem.9b00106
	CHEMBL4517597	172387	0	None	-251	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assayAgonist activity at human A2B expressed in CHO cells assessed as stimulation of cAMP production by alphascreen assay	ChEMBL	406	5	1	8	4.2	COC(=O)c1cccc(CSc2nc(N)c(C#N)c(-c3cccs3)c2C#N)c1	10.1021/acs.jmedchem.9b00106
	16203669	84567	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	467	7	5	10	0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(OCCc4c[nH]c5ccccc45)nc32)[C@H](O)[C@@H]1O	10.1021/jm061278q
	CHEMBL223845	84567	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	467	7	5	10	0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(OCCc4c[nH]c5ccccc45)nc32)[C@H](O)[C@@H]1O	10.1021/jm061278q
	156018418	177209	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Inverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP levelInverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP level	ChEMBL	500	7	3	11	1.8	Nc1nc(NCCN2CCN(c3ccc(S(N)(=O)=O)cc3)CC2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	CHEMBL4643397	177209	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Inverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP levelInverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP level	ChEMBL	500	7	3	11	1.8	Nc1nc(NCCN2CCN(c3ccc(S(N)(=O)=O)cc3)CC2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	3284	3155	28	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	44185871	3155	28	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	5728	3155	28	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	CHEMBL483688	3155	28	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	12066874	202541	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	262	1	1	5	2.7	Oc1c(-c2ccccc2)nnc2nc3ccccc3n12	10.1021/jm201177b
	CHEMBL7113	202541	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	262	1	1	5	2.7	Oc1c(-c2ccccc2)nnc2nc3ccccc3n12	10.1021/jm201177b
	25207803	5594	0	None	10	4	Human	8.9	pIC50	=	8.9	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	381	6	2	8	4.0	CNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	CHEMBL1077943	5594	0	None	10	4	Human	8.9	pIC50	=	8.9	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	381	6	2	8	4.0	CNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	156821415	184881	0	None	5	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	398	4	1	8	3.0	Nc1nc(-c2ccccc2)c(-c2ccnnc2)c2nc(Cc3ncccc3F)nn12	10.1021/acsmedchemlett.1c00620
	CHEMBL4862010	184881	0	None	5	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	398	4	1	8	3.0	Nc1nc(-c2ccccc2)c(-c2ccnnc2)c2nc(Cc3ncccc3F)nn12	10.1021/acsmedchemlett.1c00620
	44186667	185067	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486479	185067	0	None	-	1	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44186622	183637	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL483469	183637	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	10641040	9658	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	342	3	0	6	3.4	O=c1c(-c2ccco2)nnc2n(Cc3ccccc3)c3ccccc3n12	10.1021/jm201177b
	CHEMBL113518	9658	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	342	3	0	6	3.4	O=c1c(-c2ccco2)nnc2n(Cc3ccccc3)c3ccccc3n12	10.1021/jm201177b
	11605883	79527	5	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL212625	79527	5	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44185933	186117	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	522	8	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL488541	186117	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	522	8	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	135493268	109984	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32481	109984	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	134142435	144793	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	341	4	2	7	3.7	Nc1nc(NCc2cccc(F)c2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3913413	144793	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	341	4	2	7	3.7	Nc1nc(NCc2cccc(F)c2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	45481749	196847	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	437	5	1	8	4.1	CCn1cc2c(nc(NC(=O)Cc3ccc4ccccc4c3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL578008	196847	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	437	5	1	8	4.1	CCn1cc2c(nc(NC(=O)Cc3ccc4ccccc4c3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	60156108	76618	0	None	-69	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	532	5	3	9	2.9	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccc(F)cc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2071046	76618	0	None	-69	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	532	5	3	9	2.9	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccc(F)cc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	135874429	95298	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	483	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4cccc(Cl)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL258473	95298	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	483	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4cccc(Cl)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	57429602	156685	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 releaseAntagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	CHEMBL4076435	156685	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 releaseAntagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	51039214	71164	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	342	5	3	9	1.5	NCC1CCC(CNc2nc(N)n3nc(-c4ccco4)nc3n2)CC1	10.1021/jm101349u
	CHEMBL1927444	71164	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	342	5	3	9	1.5	NCC1CCC(CNc2nc(N)n3nc(-c4ccco4)nc3n2)CC1	10.1021/jm101349u
	CHEMBL1962813	71164	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	342	5	3	9	1.5	NCC1CCC(CNc2nc(N)n3nc(-c4ccco4)nc3n2)CC1	10.1021/jm101349u
	135522388	99637	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	543	9	2	9	2.9	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL287529	99637	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	543	9	2	9	2.9	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	46883206	6225	0	None	10	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	347	5	1	7	3.3	O=C(c1cccnc1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1081873	6225	0	None	10	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	347	5	1	7	3.3	O=C(c1cccnc1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	145436767	161916	0	None	-4365	2	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	324	4	2	8	2.9	Nc1nc(NCc2cccnc2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4167125	161916	0	None	-4365	2	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	324	4	2	8	2.9	Nc1nc(NCc2cccnc2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	136042340	70807	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	527	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Br)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955916	70807	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	527	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Br)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	10007115	115831	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	527	8	1	8	5.7	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL335950	115831	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	527	8	1	8	5.7	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	52947525	17462	0	None	-389	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at adenosine A2B receptor by cAMP assayAntagonist activity at adenosine A2B receptor by cAMP assay	ChEMBL	451	6	2	7	5.2	COc1ccc(Nc2c(-c3ccc4nccnc4c3)c(C)nn2-c2ccccc2)c(C(=O)O)c1	10.1016/j.bmcl.2010.07.095
	CHEMBL1258397	17462	0	None	-389	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at adenosine A2B receptor by cAMP assayAntagonist activity at adenosine A2B receptor by cAMP assay	ChEMBL	451	6	2	7	5.2	COc1ccc(Nc2c(-c3ccc4nccnc4c3)c(C)nn2-c2ccccc2)c(C(=O)O)c1	10.1016/j.bmcl.2010.07.095
	1922	201121	39	None	-363	9	Rat	6.0	pIC50	=	6.0	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm990499b
	CHEMBL62350	201121	39	None	-363	9	Rat	6.0	pIC50	=	6.0	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm990499b
	145960667	160923	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	285	4	2	6	2.6	Cc1nc2c(N)nc(NCCc3ccccc3)nc2s1	10.1016/j.bmc.2018.05.048
	CHEMBL4127811	160923	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	285	4	2	6	2.6	Cc1nc2c(N)nc(NCCc3ccccc3)nc2s1	10.1016/j.bmc.2018.05.048
	60156105	76616	0	None	-38	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	514	5	3	9	2.8	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2071044	76616	0	None	-38	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	514	5	3	9	2.8	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	45481761	196318	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	539	8	1	8	5.8	O=C(Cc1ccc(-c2ccccc2)cc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2009.05.038
	CHEMBL573771	196318	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	539	8	1	8	5.8	O=C(Cc1ccc(-c2ccccc2)cc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2009.05.038
	51051249	68930	1	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	217	1	2	8	-0.1	Nc1nc(N)n2nc(-c3ccco3)nc2n1	10.1021/jm101349u
	CHEMBL1927632	68930	1	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	217	1	2	8	-0.1	Nc1nc(N)n2nc(-c3ccco3)nc2n1	10.1021/jm101349u
	127046494	139202	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	307	3	2	7	2.4	Nc1nc(-c2ccco2)nc2cn(Cc3ccccc3O)nc12	10.1016/j.bmc.2016.04.048
	CHEMBL3798383	139202	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	307	3	2	7	2.4	Nc1nc(-c2ccco2)nc2cn(Cc3ccccc3O)nc12	10.1016/j.bmc.2016.04.048
	145436765	162233	0	None	-2511	2	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	343	5	2	8	3.6	Nc1nc(NCCc2cccs2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4172264	162233	0	None	-2511	2	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	343	5	2	8	3.6	Nc1nc(NCCc2cccs2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	136042342	70809	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	479	9	2	10	2.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(OC)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955918	70809	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	479	9	2	10	2.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(OC)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	135874414	95795	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	575	8	2	8	3.1	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(I)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL261027	95795	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	575	8	2	8	3.1	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(I)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	135443359	487	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	441	487	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL431703	487	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	127036844	137020	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	397	7	2	8	4.0	c1ccc(CNc2nc(NCc3ccccc3)n3nc(-c4ccco4)nc3n2)cc1	10.1016/j.ejmech.2015.12.019
	CHEMBL3754573	137020	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	397	7	2	8	4.0	c1ccc(CNc2nc(NCc3ccccc3)n3nc(-c4ccco4)nc3n2)cc1	10.1016/j.ejmech.2015.12.019
	49797906	10629	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	467	7	1	7	4.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(F)c4)c3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171165	10629	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	467	7	1	7	4.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(F)c4)c3)sc12	10.1016/j.bmcl.2010.05.056
	9930130	10685	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	387	5	1	5	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171897	10685	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	387	5	1	5	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	25231167	6125	0	None	20	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	313	5	2	6	2.4	CCNC(=O)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1081335	6125	0	None	20	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	313	5	2	6	2.4	CCNC(=O)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	16071896	57704	37	None	4	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase of intracellular cAMP level after 30 mins by ELISAAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase of intracellular cAMP level after 30 mins by ELISA	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672627	57704	37	None	4	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase of intracellular cAMP level after 30 mins by ELISAAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase of intracellular cAMP level after 30 mins by ELISA	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	71508481	85835	6	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2b receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation by scintillation countingAntagonist activity at human adenosine A2b receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation by scintillation counting	ChEMBL	250	1	1	5	2.7	Nc1nc2ccccc2c2cc(-c3ccco3)nn12	10.1016/j.bmc.2012.10.031
	CHEMBL2312725	85835	6	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2b receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation by scintillation countingAntagonist activity at human adenosine A2b receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation by scintillation counting	ChEMBL	250	1	1	5	2.7	Nc1nc2ccccc2c2cc(-c3ccco3)nn12	10.1016/j.bmc.2012.10.031
	135529386	486	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	440	486	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	CHEMBL284615	486	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	135546657	157144	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL408186	157144	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1021/jm0309654
	145954471	161820	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	367	5	2	8	3.9	COc1cccc(CNc2nc(N)c3nc(-c4ccc(C)o4)sc3n2)c1	10.1016/j.ejmech.2018.06.020
	CHEMBL4165484	161820	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	367	5	2	8	3.9	COc1cccc(CNc2nc(N)c3nc(-c4ccc(C)o4)sc3n2)c1	10.1016/j.ejmech.2018.06.020
	11793210	185280	0	None	-7	2	Rat	5.9	pIC50	=	5.9	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	365	1	2	6	2.8	Cn1c(-c2ccc(F)cc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL48681	185280	0	None	-7	2	Rat	5.9	pIC50	=	5.9	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	365	1	2	6	2.8	Cn1c(-c2ccc(F)cc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	57395163	69431	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3cnn(C)c3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	CHEMBL1935756	69431	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3cnn(C)c3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	45482090	196269	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	463	7	1	8	4.6	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL573327	196269	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	463	7	1	8	4.6	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	118708225	112846	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	319	3	1	5	3.1	Nc1nc(Cc2ccccc2F)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	CHEMBL3317565	112846	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	319	3	1	5	3.1	Nc1nc(Cc2ccccc2F)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	45482075	196616	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	451	6	1	8	4.5	CCCn1cc2c(nc(NC(=O)Cc3cccc4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL576018	196616	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	451	6	1	8	4.5	CCCn1cc2c(nc(NC(=O)Cc3cccc4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	46882998	5550	0	None	-10	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	303	4	1	6	3.7	CCNc1nc(C(=O)c2ccc(C)s2)c2sccc2n1	10.1016/j.bmcl.2009.08.040
	CHEMBL1077752	5550	0	None	-10	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	303	4	1	6	3.7	CCNc1nc(C(=O)c2ccc(C)s2)c2sccc2n1	10.1016/j.bmcl.2009.08.040
	164627235	185821	0	None	-22	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	433	4	2	7	3.2	Cc1cc(-c2c(-c3ccc(F)cc3)nc(N)n3nc(CN4CCCCC4)nc23)c[nH]c1=O	10.1021/acsmedchemlett.1c00620
	CHEMBL4876056	185821	0	None	-22	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	433	4	2	7	3.2	Cc1cc(-c2c(-c3ccc(F)cc3)nc(N)n3nc(CN4CCCCC4)nc23)c[nH]c1=O	10.1021/acsmedchemlett.1c00620
	135493281	109125	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	483	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(Cl)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32225	109125	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	483	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(Cl)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	46883205	5758	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	376	6	1	7	3.9	COc1ccc(C(=O)c2nc(NCc3cccnc3)nc3ccsc23)cc1	10.1016/j.bmcl.2009.08.040
	CHEMBL1079232	5758	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	376	6	1	7	3.9	COc1ccc(C(=O)c2nc(NCc3cccnc3)nc3ccsc23)cc1	10.1016/j.bmcl.2009.08.040
	155554091	175108	0	None	-4	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayAntagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assay	ChEMBL	375	5	2	7	3.1	N#Cc1c(N)nc(SCc2cccc(C(N)=O)c2)c(C#N)c1-c1ccco1	10.1021/acs.jmedchem.9b00106
	CHEMBL4581984	175108	0	None	-4	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayAntagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assay	ChEMBL	375	5	2	7	3.1	N#Cc1c(N)nc(SCc2cccc(C(N)=O)c2)c(C#N)c1-c1ccco1	10.1021/acs.jmedchem.9b00106
	49798140	10754	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	484	9	1	7	3.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N(C)CCOC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172442	10754	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	484	9	1	7	3.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N(C)CCOC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	25231166	6261	0	None	181	2	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	4	1	6	3.5	CC(Nc1nc(C(=O)N2CCCC2)c2sccc2n1)c1cccnc1	10.1016/j.bmcl.2009.08.040
	CHEMBL1082064	6261	0	None	181	2	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	4	1	6	3.5	CC(Nc1nc(C(=O)N2CCCC2)c2sccc2n1)c1cccnc1	10.1016/j.bmcl.2009.08.040
	54581142	60393	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	598	8	2	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NS(=O)(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760896	60393	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	598	8	2	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NS(=O)(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	145436761	162275	0	None	-1	2	Human	7.9	pIC50	=	7.9	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	325	4	2	9	2.3	Nc1nc(NCc2cnccn2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4172818	162275	0	None	-1	2	Human	7.9	pIC50	=	7.9	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	325	4	2	9	2.3	Nc1nc(NCc2cnccn2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	11826924	118227	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	479	8	1	9	4.0	O=C(COc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL341777	118227	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	479	8	1	9	4.0	O=C(COc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	10665407	190144	0	None	-	1	Rat	5.9	pIC50	=	5.9	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	348	1	2	7	2.1	Cn1c(-c2ccccn2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL51829	190144	0	None	-	1	Rat	5.9	pIC50	=	5.9	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	348	1	2	7	2.1	Cn1c(-c2ccccn2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	45482076	196415	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	391	4	1	8	2.6	Cn1cc2c(nc(NC(=O)Cc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL574483	196415	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	391	4	1	8	2.6	Cn1cc2c(nc(NC(=O)Cc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	46238067	8406	0	None	-229	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	420	5	2	5	5.2	O=C(Nc1ccccc1)Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12	10.1021/jm901785w
	CHEMBL1094132	8406	0	None	-229	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	420	5	2	5	5.2	O=C(Nc1ccccc1)Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12	10.1021/jm901785w
	46238066	8405	0	None	-173	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	439	5	1	5	5.4	O=C(Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12)c1cccc(Cl)c1	10.1021/jm901785w
	CHEMBL1094131	8405	0	None	-173	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	439	5	1	5	5.4	O=C(Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12)c1cccc(Cl)c1	10.1021/jm901785w
	145962529	160832	0	None	-1	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	291	4	2	7	2.7	Cc1nc2c(N)nc(NCCc3cccs3)nc2s1	10.1016/j.bmc.2018.05.048
	CHEMBL4126427	160832	0	None	-1	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	291	4	2	7	2.7	Cc1nc2c(N)nc(NCCc3cccs3)nc2s1	10.1016/j.bmc.2018.05.048
	15729970	136761	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	299	3	2	8	2.1	Nc1nc(NC2CCCCC2)nc2nc(-c3ccco3)nn12	10.1016/j.ejmech.2015.12.019
	CHEMBL3752431	136761	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	299	3	2	8	2.1	Nc1nc(NC2CCCCC2)nc2nc(-c3ccco3)nn12	10.1016/j.ejmech.2015.12.019
	145964662	163875	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	433	8	3	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4213768	163875	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	433	8	3	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	45481758	196659	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	379	4	1	9	2.5	Cn1cc2c(nc(NC(=O)Cc3ccsc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL576369	196659	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	379	4	1	9	2.5	Cn1cc2c(nc(NC(=O)Cc3ccsc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	45481619	196640	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	463	7	1	8	4.6	CC(C)CCn1cc2c(nc(NC(=O)Cc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL576185	196640	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	463	7	1	8	4.6	CC(C)CCn1cc2c(nc(NC(=O)Cc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	53248698	60384	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	6	1	6	4.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CCN(C(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760886	60384	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	6	1	6	4.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CCN(C(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	10544916	187715	0	None	15	2	Human	7.9	pIC50	=	7.9	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	337	1	2	7	2.3	Cn1c(-c2ccco2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL50051	187715	0	None	15	2	Human	7.9	pIC50	=	7.9	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	337	1	2	7	2.3	Cn1c(-c2ccco2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	145436762	161948	0	None	-3	2	Human	7.9	pIC50	=	7.9	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	327	5	2	8	3.2	Nc1nc(NCCc2ccco2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4167557	161948	0	None	-3	2	Human	7.9	pIC50	=	7.9	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	327	5	2	8	3.2	Nc1nc(NCCc2ccco2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	11027412	29401	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	493	9	1	9	4.4	O=C(COc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL138593	29401	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	493	9	1	9	4.4	O=C(COc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	135465785	485	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	439	485	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL32582	485	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	10665761	188677	0	None	3	2	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	353	3	2	6	2.7	CCC(O)(C#Cc1nc(N)c2nc(-c3cccc(F)c3)n(C)c2n1)CC	10.1021/jm990499b
	CHEMBL51192	188677	0	None	3	2	Human	6.9	pIC50	=	6.9	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	353	3	2	6	2.7	CCC(O)(C#Cc1nc(N)c2nc(-c3cccc(F)c3)n(C)c2n1)CC	10.1021/jm990499b
	145976828	163115	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	447	9	3	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4204683	163115	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	447	9	3	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	45482081	196242	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	497	7	1	8	5.3	CC(C)CCn1cc2c(nc(NC(=O)Cc3c(Cl)cccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL573089	196242	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	497	7	1	8	5.3	CC(C)CCn1cc2c(nc(NC(=O)Cc3c(Cl)cccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	156010667	176533	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP productionInhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP production	ChEMBL	556	9	4	11	2.0	Nc1nc(NCC2CCN(CC(=O)NCc3ccc(S(N)(=O)=O)cc3)CC2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	CHEMBL4633630	176533	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP productionInhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP production	ChEMBL	556	9	4	11	2.0	Nc1nc(NCC2CCN(CC(=O)NCc3ccc(S(N)(=O)=O)cc3)CC2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	46238068	8632	0	None	-181	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	450	6	2	6	5.2	COc1ccc(NC(=O)Nc2nc(-c3ccccc3)nc3nn(Cc4ccccc4)cc23)cc1	10.1021/jm901785w
	CHEMBL1096078	8632	0	None	-181	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	450	6	2	6	5.2	COc1ccc(NC(=O)Nc2nc(-c3ccccc3)nc3nn(Cc4ccccc4)cc23)cc1	10.1021/jm901785w
	46883157	5730	0	None	11	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	5	1	8	3.4	O=C(c1cncs1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1079044	5730	0	None	11	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	5	1	8	3.4	O=C(c1cncs1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	46883155	5745	0	None	2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	352	5	1	7	4.0	O=C(c1ccsc1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1079132	5745	0	None	2	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	352	5	1	7	4.0	O=C(c1ccsc1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	10449783	9540	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	338	2	0	5	3.7	O=c1c(-c2ccccc2)nnc2n(-c3ccccc3)c3ccccc3n12	10.1021/jm201177b
	CHEMBL112756	9540	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	338	2	0	5	3.7	O=c1c(-c2ccccc2)nnc2n(-c3ccccc3)c3ccccc3n12	10.1021/jm201177b
	10237267	10686	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	373	4	1	5	3.7	COc1ccc(N(C)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171898	10686	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	373	4	1	5	3.7	COc1ccc(N(C)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	136042350	70791	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	496	8	2	9	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955899	70791	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	496	8	2	9	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	10824674	203190	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	252	1	1	6	2.2	Oc1c(-c2ccco2)nnc2nc3ccccc3n12	10.1021/jm201177b
	CHEMBL7608	203190	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	252	1	1	6	2.2	Oc1c(-c2ccco2)nnc2nc3ccccc3n12	10.1021/jm201177b
	10895565	167876	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	445	8	1	9	3.8	CC(C)CCn1cc2c(nc(NC(=O)COc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	CHEMBL435022	167876	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	445	8	1	9	3.8	CC(C)CCn1cc2c(nc(NC(=O)COc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	10616023	101379	0	None	3	2	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	325	1	2	6	1.9	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC(C)(C)O)nc21	10.1021/jm990499b
	CHEMBL300624	101379	0	None	3	2	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	325	1	2	6	1.9	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC(C)(C)O)nc21	10.1021/jm990499b
	6448585	97874	5	None	-1513	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	412	8	0	8	2.9	CCCn1c(=O)c2c(nc(/C=C/c3ccc(OC)c(OC)c3)n2C)n(CCC)c1=O	10.1021/jm990499b
	CHEMBL2311150	97874	5	None	-1513	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	412	8	0	8	2.9	CCCn1c(=O)c2c(nc(/C=C/c3ccc(OC)c(OC)c3)n2C)n(CCC)c1=O	10.1021/jm990499b
	CHEMBL27508	97874	5	None	-1513	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	412	8	0	8	2.9	CCCn1c(=O)c2c(nc(/C=C/c3ccc(OC)c(OC)c3)n2C)n(CCC)c1=O	10.1021/jm990499b
	45481757	196320	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	393	5	1	9	3.0	CCn1cc2c(nc(NC(=O)Cc3cccs3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL573779	196320	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	393	5	1	9	3.0	CCn1cc2c(nc(NC(=O)Cc3cccs3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	155554464	174020	0	None	-30	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayAntagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assay	ChEMBL	362	5	2	7	3.5	N#Cc1c(N)nc(SCc2cccc(CO)c2)c(C#N)c1-c1ccco1	10.1021/acs.jmedchem.9b00106
	CHEMBL4557250	174020	0	None	-30	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayAntagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assay	ChEMBL	362	5	2	7	3.5	N#Cc1c(N)nc(SCc2cccc(CO)c2)c(C#N)c1-c1ccco1	10.1021/acs.jmedchem.9b00106
	127045701	139427	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	339	3	1	6	3.7	Cc1ccc(-c2nc(N)c3nn(Cc4ccccc4Cl)cc3n2)o1	10.1016/j.bmc.2016.04.048
	CHEMBL3799848	139427	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	339	3	1	6	3.7	Cc1ccc(-c2nc(N)c3nn(Cc4ccccc4Cl)cc3n2)o1	10.1016/j.bmc.2016.04.048
	136002186	109200	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32281	109200	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	23656936	154345	0	None	-2630	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP accumulationAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP accumulation	ChEMBL	425	4	1	7	3.6	COc1ccc(C(=O)Nc2nc3ccccc3n3c(=O)c(-c4ccc(C)cc4)nn23)cc1	10.1021/jm0708376
	CHEMBL400812	154345	0	None	-2630	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP accumulationAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP accumulation	ChEMBL	425	4	1	7	3.6	COc1ccc(C(=O)Nc2nc3ccccc3n3c(=O)c(-c4ccc(C)cc4)nn23)cc1	10.1021/jm0708376
	60156107	76617	0	None	-33	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	542	7	3	9	3.2	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCCCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2071045	76617	0	None	-33	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	542	7	3	9	3.2	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCCCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	135874415	95437	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	527	8	2	8	3.3	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Br)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL259177	95437	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	527	8	2	8	3.3	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Br)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	156018055	177336	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP productionInhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP production	ChEMBL	570	10	4	11	2.1	Nc1nc(NCC2CCN(CC(=O)NCCc3ccc(S(N)(=O)=O)cc3)CC2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	CHEMBL4645283	177336	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP productionInhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP production	ChEMBL	570	10	4	11	2.1	Nc1nc(NCC2CCN(CC(=O)NCCc3ccc(S(N)(=O)=O)cc3)CC2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	49797748	10505	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	480	6	1	6	4.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCCCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170135	10505	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	480	6	1	6	4.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCCCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49798137	10630	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	466	6	1	6	4.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171200	10630	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	466	6	1	6	4.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	46883208	5888	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	386	5	1	7	4.6	O=C(c1cccs1)c1nc(NCc2cccnc2)nc2cc(Cl)sc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1080068	5888	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	386	5	1	7	4.6	O=C(c1cccs1)c1nc(NCc2cccnc2)nc2cc(Cl)sc12	10.1016/j.bmcl.2009.08.040
	54581142	60382	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	598	8	2	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@@H](NS(=O)(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760884	60382	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	598	8	2	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@@H](NS(=O)(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	44186717	183553	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	538	8	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL482855	183553	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	538	8	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	135465774	110978	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	467	8	2	8	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(F)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32770	110978	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	467	8	2	8	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(F)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	11793210	185280	0	None	7	2	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	365	1	2	6	2.8	Cn1c(-c2ccc(F)cc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL48681	185280	0	None	7	2	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	365	1	2	6	2.8	Cn1c(-c2ccc(F)cc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	10667322	101018	0	None	-	1	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	377	2	2	7	2.7	COc1cccc(-c2nc3c(N)nc(C#CC4(O)CCCCC4)nc3n2C)c1	10.1021/jm990499b
	CHEMBL297949	101018	0	None	-	1	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	377	2	2	7	2.7	COc1cccc(-c2nc3c(N)nc(C#CC4(O)CCCCC4)nc3n2C)c1	10.1021/jm990499b
	46883107	5740	0	None	5	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	5	1	7	4.9	Cc1ccc(C(=O)c2nc(NC(C)c3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1079115	5740	0	None	5	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	5	1	7	4.9	Cc1ccc(C(=O)c2nc(NC(C)c3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	54584124	60389	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	6	1	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)C3CCN(C(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760892	60389	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	6	1	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)C3CCN(C(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	10906943	116017	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	479	7	1	8	5.1	CC(C)CCn1cc2c(nc(NC(=O)Cc3cccc4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	CHEMBL336217	116017	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	479	7	1	8	5.1	CC(C)CCn1cc2c(nc(NC(=O)Cc3cccc4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	155520955	169993	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assay	ChEMBL	351	2	4	9	1.2	Nc1nc(-c2cc(O)c(O)c(O)c2)cn2c(=O)n(-c3ccccc3)nc12	10.1021/acs.jmedchem.9b00778
	CHEMBL4450312	169993	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assay	ChEMBL	351	2	4	9	1.2	Nc1nc(-c2cc(O)c(O)c(O)c2)cn2c(=O)n(-c3ccccc3)nc12	10.1021/acs.jmedchem.9b00778
	145964230	163448	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	461	10	3	6	2.6	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4208432	163448	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	461	10	3	6	2.6	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	60156106	76435	0	None	-75	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	528	6	3	9	2.8	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2069325	76435	0	None	-75	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	528	6	3	9	2.8	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCCc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	46883156	5729	0	None	4	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	5	1	8	3.4	O=C(c1nccs1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1079043	5729	0	None	4	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	5	1	8	3.4	O=C(c1nccs1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	134147994	149565	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	351	6	2	7	4.0	Nc1nc(NCCCc2ccccc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3951103	149565	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	351	6	2	7	4.0	Nc1nc(NCCCc2ccccc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	46883110	5743	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	352	5	1	7	4.0	O=C(c1cccs1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1079118	5743	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	352	5	1	7	4.0	O=C(c1cccs1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	25230181	5867	0	None	26	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	4	1	6	3.5	C[C@H](Nc1nc(C(=O)N2CCCC2)c2sccc2n1)c1cccnc1	10.1016/j.bmcl.2009.08.040
	CHEMBL1079894	5867	0	None	26	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	4	1	6	3.5	C[C@H](Nc1nc(C(=O)N2CCCC2)c2sccc2n1)c1cccnc1	10.1016/j.bmcl.2009.08.040
	54585058	60396	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	520	5	1	5	6.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)N3CCC(c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760900	60396	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	520	5	1	5	6.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)N3CCC(c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	134152846	152996	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	369	5	4	9	3.0	Nc1nc(NCCc2ccc(O)c(O)c2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3980049	152996	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	369	5	4	9	3.0	Nc1nc(NCCc2ccc(O)c(O)c2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	3284	3155	28	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	44185871	3155	28	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	5728	3155	28	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	CHEMBL483688	3155	28	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	136042335	70803	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	490	8	2	10	1.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc(=O)c5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955911	70803	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	490	8	2	10	1.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc(=O)c5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	11762982	25985	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	513	7	1	8	5.3	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL135719	25985	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	513	7	1	8	5.3	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	145960536	161067	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	271	3	2	6	2.6	Cc1nc2c(N)nc(NCc3ccccc3)nc2s1	10.1016/j.bmc.2018.05.048
	CHEMBL4130003	161067	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	271	3	2	6	2.6	Cc1nc2c(N)nc(NCc3ccccc3)nc2s1	10.1016/j.bmc.2018.05.048
	45482085	196418	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	421	7	1	9	3.8	CCCCn1cc2c(nc(NC(=O)Cc3cccs3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL574489	196418	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	421	7	1	9	3.8	CCCCn1cc2c(nc(NC(=O)Cc3cccs3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	135529391	478	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	438	478	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL285900	478	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	134157761	153483	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	289	5	2	7	3.1	CCCCNc1nc(N)c2nc(-c3ccco3)sc2n1	10.1021/acs.jmedchem.6b01068
	CHEMBL3984266	153483	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	289	5	2	7	3.1	CCCCNc1nc(N)c2nc(-c3ccco3)sc2n1	10.1021/acs.jmedchem.6b01068
	135874430	159571	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	517	8	2	8	3.8	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Cl)c(Cl)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL410895	159571	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	517	8	2	8	3.8	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Cl)c(Cl)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	25231168	5607	0	None	32	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	339	4	1	6	2.9	O=C(c1nc(NCc2cccnc2)nc2ccsc12)N1CCCC1	10.1016/j.bmcl.2009.08.040
	CHEMBL1078030	5607	0	None	32	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	339	4	1	6	2.9	O=C(c1nc(NCc2cccnc2)nc2ccsc12)N1CCCC1	10.1016/j.bmcl.2009.08.040
	49797856	10735	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	401	5	1	5	4.5	COc1ccc(N(C(C)=O)C(C)C)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172270	10735	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	401	5	1	5	4.5	COc1ccc(N(C(C)=O)C(C)C)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	49797771	10739	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	435	6	1	7	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4ccnc4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172275	10739	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	435	6	1	7	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4ccnc4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49797773	10741	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	490	8	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(CN(C)S(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172277	10741	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	490	8	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(CN(C)S(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	46883106	5592	0	None	6	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	5	1	7	4.9	Cc1ccc(C(=O)c2nc(NC(C)c3ccccn3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1077915	5592	0	None	6	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	5	1	7	4.9	Cc1ccc(C(=O)c2nc(NC(C)c3ccccn3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	25230948	5943	0	None	3	4	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	395	7	2	8	4.4	CCNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1080421	5943	0	None	3	4	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	395	7	2	8	4.4	CCNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	10.1016/j.bmcl.2009.08.040
	54583134	62764	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	8	2	6	5.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760891	62764	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	8	2	6	5.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1789250	62764	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	8	2	6	5.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	11080491	22579	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	429	7	1	8	4.0	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	CHEMBL132806	22579	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	429	7	1	8	4.0	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	10597086	206333	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor at 50 uMInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor at 50 uM	ChEMBL	399	6	2	7	3.4	O=C(O)CCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	CHEMBL97753	206333	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor at 50 uMInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor at 50 uM	ChEMBL	399	6	2	7	3.4	O=C(O)CCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	52948788	17533	0	None	-2137	2	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at adenosine A2B receptor by cAMP assayAntagonist activity at adenosine A2B receptor by cAMP assay	ChEMBL	489	5	2	6	6.3	Cc1ccccc1-n1nc(C(F)(F)F)c(-c2ccc3nccnc3c2)c1Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.07.095
	CHEMBL1258622	17533	0	None	-2137	2	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at adenosine A2B receptor by cAMP assayAntagonist activity at adenosine A2B receptor by cAMP assay	ChEMBL	489	5	2	6	6.3	Cc1ccccc1-n1nc(C(F)(F)F)c(-c2ccc3nccnc3c2)c1Nc1ccccc1C(=O)O	10.1016/j.bmcl.2010.07.095
	136042345	70812	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	585	8	2	9	4.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C(F)(F)F)cc(C(F)(F)F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955921	70812	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	585	8	2	9	4.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C(F)(F)F)cc(C(F)(F)F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	56964460	74359	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	362	2	0	6	3.9	O=c1c(-c2ccco2)nnc2n(-c3ccc(Cl)cc3)c3ccccc3n12	10.1021/jm201177b
	CHEMBL2030704	74359	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	362	2	0	6	3.9	O=c1c(-c2ccco2)nnc2n(-c3ccc(Cl)cc3)c3ccccc3n12	10.1021/jm201177b
	44186668	190904	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL519390	190904	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	56964459	74358	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	372	2	0	5	4.4	O=c1c(-c2ccccc2)nnc2n(-c3ccc(Cl)cc3)c3ccccc3n12	10.1021/jm201177b
	CHEMBL2030703	74358	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	372	2	0	5	4.4	O=c1c(-c2ccccc2)nnc2n(-c3ccc(Cl)cc3)c3ccccc3n12	10.1021/jm201177b
	56964461	74360	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	366	4	0	5	4.0	O=c1c(-c2ccccc2)nnc2n(CCc3ccccc3)c3ccccc3n12	10.1021/jm201177b
	CHEMBL2030705	74360	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	366	4	0	5	4.0	O=c1c(-c2ccccc2)nnc2n(CCc3ccccc3)c3ccccc3n12	10.1021/jm201177b
	56924646	70813	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	332	5	2	7	0.4	CCCn1c(=O)c2[nH]c(-c3cc(=O)[nH]n3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955922	70813	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	332	5	2	7	0.4	CCCn1c(=O)c2[nH]c(-c3cc(=O)[nH]n3C)nc2n(CCC)c1=O	10.1021/jm201292w
	53242165	60397	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	584	6	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)N3CCC(S(=O)(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760901	60397	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	584	6	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)N3CCC(S(=O)(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	10539663	202522	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	266	1	0	6	1.8	Cn1c2ccccc2n2c(=O)c(-c3ccco3)nnc12	10.1021/jm201177b
	CHEMBL7098	202522	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	266	1	0	6	1.8	Cn1c2ccccc2n2c(=O)c(-c3ccco3)nnc12	10.1021/jm201177b
	135874421	168381	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	477	8	2	8	3.1	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(C)c(C)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL438938	168381	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	477	8	2	8	3.1	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(C)c(C)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	51050845	68906	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	374	6	3	10	1.7	CC(C)(C)OC(=O)NCCCNc1nc(N)n2nc(-c3ccco3)nc2n1	10.1021/jm101349u
	CHEMBL1927428	68906	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	374	6	3	10	1.7	CC(C)(C)OC(=O)NCCCNc1nc(N)n2nc(-c3ccco3)nc2n1	10.1021/jm101349u
	60155796	76598	0	None	-16	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	471	5	2	9	3.1	Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2070886	76598	0	None	-16	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	471	5	2	9	3.1	Cn1cc2c(nc(NC(=O)NC3CCN(Cc4ccccc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	145962364	160889	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	277	3	2	7	2.7	Cc1nc2c(N)nc(NCc3cccs3)nc2s1	10.1016/j.bmc.2018.05.048
	CHEMBL4127395	160889	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	277	3	2	7	2.7	Cc1nc2c(N)nc(NCc3cccs3)nc2s1	10.1016/j.bmc.2018.05.048
	49797747	10504	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	482	6	1	7	3.4	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCOCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170134	10504	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	482	6	1	7	3.4	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCOCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49797749	10506	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	435	6	1	7	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4cccn4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170136	10506	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	435	6	1	7	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4cccn4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	46911060	10533	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170367	10533	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12	10.1016/j.bmcl.2010.05.056
	49798138	10556	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	426	6	2	6	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)NC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170582	10556	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	426	6	2	6	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)NC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49797903	10626	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	359	5	2	6	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cn[nH]c3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171162	10626	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	359	5	2	6	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cn[nH]c3)sc12	10.1016/j.bmcl.2010.05.056
	46911060	10533	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1170367	10533	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12	10.1016/j.bmcl.2011.02.053
	10994216	193240	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	463	7	1	8	4.2	O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL541455	193240	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	463	7	1	8	4.2	O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	1922	201121	39	None	-97	9	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm990499b
	CHEMBL62350	201121	39	None	-97	9	Human	6.7	pIC50	=	6.7	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm990499b
	135874431	95796	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	463	8	2	8	2.8	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(C)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL261028	95796	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	463	8	2	8	2.8	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(C)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	60154739	76620	0	None	-177	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	528	5	3	9	3.1	Cc1ccc(CNC(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1	10.1021/jm300323t
	CHEMBL2071048	76620	0	None	-177	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	528	5	3	9	3.1	Cc1ccc(CNC(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1	10.1021/jm300323t
	60154835	76831	0	None	-17	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	507	3	2	10	1.2	CN1CCN(C(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)CC1	10.1021/jm300323t
	CHEMBL2071051	76831	0	None	-17	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	507	3	2	10	1.2	CN1CCN(C(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)CC1	10.1021/jm300323t
	CHEMBL2079181	76831	0	None	-17	2	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	507	3	2	10	1.2	CN1CCN(C(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)CC1	10.1021/jm300323t
	46883159	5747	0	None	2	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	360	5	1	6	4.2	Cc1ccc(C(=O)c2nc(NCc3cccnc3)nc3ccsc23)cc1	10.1016/j.bmcl.2009.08.040
	CHEMBL1079142	5747	0	None	2	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	360	5	1	6	4.2	Cc1ccc(C(=O)c2nc(NCc3cccnc3)nc3ccsc23)cc1	10.1016/j.bmcl.2009.08.040
	136042337	70804	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	520	10	1	12	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4noc(-c5cccc(OC)c5)n4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955913	70804	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	520	10	1	12	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4noc(-c5cccc(OC)c5)n4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	136042330	70797	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	506	9	3	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(=O)O)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955905	70797	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	506	9	3	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(=O)O)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	10544916	187715	0	None	-15	2	Rat	6.7	pIC50	=	6.7	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	337	1	2	7	2.3	Cn1c(-c2ccco2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL50051	187715	0	None	-15	2	Rat	6.7	pIC50	=	6.7	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	337	1	2	7	2.3	Cn1c(-c2ccco2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	9839545	136775	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	307	4	2	8	2.0	Nc1nc(NCc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.ejmech.2015.12.019
	CHEMBL3752514	136775	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	307	4	2	8	2.0	Nc1nc(NCc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.ejmech.2015.12.019
	135874422	158527	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	509	10	2	10	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(OC)c(OC)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL409736	158527	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	509	10	2	10	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(OC)c(OC)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	49797796	10502	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	391	4	1	4	4.7	CCN(C(C)=O)c1ccc(Cl)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170130	10502	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	391	4	1	4	4.7	CCN(C(C)=O)c1ccc(Cl)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49797878	10667	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	415	6	1	5	4.7	COc1ccc(N(CC(C)C)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171718	10667	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	415	6	1	5	4.7	COc1ccc(N(CC(C)C)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	9842054	183348	0	None	10	2	Human	7.6	pIC50	=	7.6	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	365	1	2	6	2.8	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL48153	183348	0	None	10	2	Human	7.6	pIC50	=	7.6	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	365	1	2	6	2.8	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	44186719	185324	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	552	7	2	9	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486893	185324	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	552	7	2	9	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	49797854	10733	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	409	5	1	5	4.3	COc1ccc(N(C(C)=O)C(F)F)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172268	10733	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	409	5	1	5	4.3	COc1ccc(N(C(C)=O)C(F)F)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	136042348	70817	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	508	9	2	10	2.5	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc5c(c4)OCO5)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955926	70817	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	508	9	2	10	2.5	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc5c(c4)OCO5)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	145962202	160979	0	None	-64	3	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	363	5	2	7	4.0	COc1cccc(CNc2nc(N)c3nc(-c4ccccc4)sc3n2)c1	10.1016/j.bmc.2018.05.048
	CHEMBL4128596	160979	0	None	-64	3	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	363	5	2	7	4.0	COc1cccc(CNc2nc(N)c3nc(-c4ccccc4)sc3n2)c1	10.1016/j.bmc.2018.05.048
	156821341	185824	0	None	-2	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	461	4	2	9	2.5	Cn1cc(-c2c(-c3ccc(F)cc3)nc(N)n3nc([C@H](O)c4ncccc4F)nc23)ccc1=O	10.1021/acsmedchemlett.1c00620
	CHEMBL4876080	185824	0	None	-2	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	461	4	2	9	2.5	Cn1cc(-c2c(-c3ccc(F)cc3)nc(N)n3nc([C@H](O)c4ncccc4F)nc23)ccc1=O	10.1021/acsmedchemlett.1c00620
	134138275	147208	0	None	-1	2	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	339	4	3	8	3.2	Nc1nc(NCc2cccc(O)c2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3932413	147208	0	None	-1	2	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	339	4	3	8	3.2	Nc1nc(NCc2cccc(O)c2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	60155712	76593	0	None	-9	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	381	3	3	9	1.1	Cn1cc2c(nc(NC(=O)NC3CCNCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2070880	76593	0	None	-9	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	381	3	3	9	1.1	Cn1cc2c(nc(NC(=O)NC3CCNCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	11497239	11692	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	390	3	2	8	1.7	Cn1cc2c(nc(NC(=O)Nc3ccc[n+](C)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	CHEMBL1181982	11692	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	390	3	2	8	1.7	Cn1cc2c(nc(NC(=O)Nc3ccc[n+](C)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	CHEMBL203660	11692	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	390	3	2	8	1.7	Cn1cc2c(nc(NC(=O)Nc3ccc[n+](C)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	118708238	112856	0	None	-57	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	345	5	2	6	3.3	Nc1nc(CCCc2ccccc2O)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	CHEMBL3317578	112856	0	None	-57	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	345	5	2	6	3.3	Nc1nc(CCCc2ccccc2O)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	134142611	145340	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	3	8	3.3	Nc1nc(NCCc2cccc(O)c2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3917647	145340	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	3	8	3.3	Nc1nc(NCCc2cccc(O)c2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	11625796	74337	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	414	3	2	9	3.7	Cn1cc2c(nc(NC(=O)Nc3cc4ccccc4o3)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	CHEMBL203054	74337	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	414	3	2	9	3.7	Cn1cc2c(nc(NC(=O)Nc3cc4ccccc4o3)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	11733496	24686	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	477	8	1	8	4.5	O=C(Cc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL134566	24686	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibitory activity against NECA stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	477	8	1	8	4.5	O=C(Cc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	9842054	183348	0	None	-10	2	Rat	6.6	pIC50	=	6.6	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	365	1	2	6	2.8	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL48153	183348	0	None	-10	2	Rat	6.6	pIC50	=	6.6	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	365	1	2	6	2.8	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	57391653	69420	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	358	5	1	7	3.6	Nc1nc2cn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	CHEMBL1935746	69420	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	358	5	1	7	3.6	Nc1nc2cn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	25231169	5424	0	None	2	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	325	5	2	6	2.6	O=C(NC1CC1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1076503	5424	0	None	2	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	325	5	2	6	2.6	O=C(NC1CC1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	136002248	70799	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	564	8	2	9	4.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(Cl)cc(C(F)(F)F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955907	70799	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	564	8	2	9	4.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(Cl)cc(C(F)(F)F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	54585057	60394	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	562	7	2	6	5.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@@H](NC(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760898	60394	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	562	7	2	6	5.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@@H](NC(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	11560202	74338	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	391	3	2	9	1.5	Cn1cc2c(nc(NC(=O)Nc3ccc[n+]([O-])c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	CHEMBL203060	74338	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	391	3	2	9	1.5	Cn1cc2c(nc(NC(=O)Nc3ccc[n+]([O-])c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	145977111	163202	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	617	9	3	7	3.9	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4205635	163202	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting methodAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-induced cAMP accumulation preincubated for 1 hr followed by NECA induction measured after 5 mins in presence of [3H]cAMP and bovine cAMP-binding protein by liquid scintillation counting method	ChEMBL	617	9	3	7	3.9	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	145962355	160877	0	None	-416	3	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	363	5	2	7	4.0	COc1ccccc1CNc1nc(N)c2nc(-c3ccccc3)sc2n1	10.1016/j.bmc.2018.05.048
	CHEMBL4127213	160877	0	None	-416	3	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	363	5	2	7	4.0	COc1ccccc1CNc1nc(N)c2nc(-c3ccccc3)sc2n1	10.1016/j.bmc.2018.05.048
	135874428	166990	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	479	9	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4cccc(OC)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL430044	166990	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	479	9	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4cccc(OC)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	57403905	69437	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	345	4	1	8	2.6	Nc1nc2cn(CCc3ccccc3)nc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	CHEMBL1935762	69437	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	345	4	1	8	2.6	Nc1nc2cn(CCc3ccccc3)nc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	136042346	70815	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	461	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955924	70815	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	461	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	46238064	8410	0	None	-5	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	405	5	1	5	4.8	O=C(Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12)c1ccccc1	10.1021/jm901785w
	CHEMBL1094143	8410	0	None	-5	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	405	5	1	5	4.8	O=C(Nc1nc(-c2ccccc2)nc2nn(Cc3ccccc3)cc12)c1ccccc1	10.1021/jm901785w
	145972655	162468	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	369	5	2	8	4.0	COc1cccc(CNc2nc(N)c3nc(-c4cccs4)sc3n2)c1	10.1016/j.ejmech.2018.06.020
	CHEMBL4175878	162468	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	369	5	2	8	4.0	COc1cccc(CNc2nc(N)c3nc(-c4cccs4)sc3n2)c1	10.1016/j.ejmech.2018.06.020
	49797794	10473	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	394	5	1	6	3.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C#N)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1169934	10473	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	394	5	1	6	3.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C#N)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49797750	10638	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	437	6	1	9	2.9	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4cnnn4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171349	10638	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	437	6	1	9	2.9	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4cnnn4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49797772	10740	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	466	7	1	6	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(CN4CCCC4=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172276	10740	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	466	7	1	6	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(CN4CCCC4=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	156017813	177243	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP productionInhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP production	ChEMBL	402	5	3	9	2.2	Nc1nc(NCc2ccc(S(N)(=O)=O)cc2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	CHEMBL4643898	177243	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP productionInhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP production	ChEMBL	402	5	3	9	2.2	Nc1nc(NCc2ccc(S(N)(=O)=O)cc2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	54585057	60392	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	562	7	2	6	5.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NC(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760895	60392	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	562	7	2	6	5.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NC(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	11684980	12192	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	390	3	2	8	1.7	Cn1cc2c(nc(NC(=O)Nc3cccc[n+]3C)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	CHEMBL1185010	12192	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	390	3	2	8	1.7	Cn1cc2c(nc(NC(=O)Nc3cccc[n+]3C)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	CHEMBL383689	12192	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	390	3	2	8	1.7	Cn1cc2c(nc(NC(=O)Nc3cccc[n+]3C)n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	164611330	184491	0	None	-380	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	418	4	2	6	3.4	Nc1nc(-c2ccc(F)cc2)c(-c2ccc(=O)[nH]c2)c2nc(CCC(F)(F)F)nn12	10.1021/acsmedchemlett.1c00620
	CHEMBL4855908	184491	0	None	-380	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	418	4	2	6	3.4	Nc1nc(-c2ccc(F)cc2)c(-c2ccc(=O)[nH]c2)c2nc(CCC(F)(F)F)nn12	10.1021/acsmedchemlett.1c00620
	134138961	147079	0	None	-1	2	Human	6.6	pIC50	=	6.6	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	2	8	3.5	COc1ccc(CNc2nc(N)c3nc(-c4ccco4)sc3n2)cc1	10.1021/acs.jmedchem.6b01068
	CHEMBL3931329	147079	0	None	-1	2	Human	6.6	pIC50	=	6.6	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	2	8	3.5	COc1ccc(CNc2nc(N)c3nc(-c4ccco4)sc3n2)cc1	10.1021/acs.jmedchem.6b01068
	46883071	5602	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	4	1	7	3.9	Cc1ccc(C(=O)c2nc(NC(=O)c3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1078001	5602	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	4	1	7	3.9	Cc1ccc(C(=O)c2nc(NC(=O)c3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	49797904	10627	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(C)c3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171163	10627	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(C)c3)sc12	10.1016/j.bmcl.2010.05.056
	127046050	139548	0	None	-45	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	335	4	1	7	3.0	COc1cccc(Cn2cc3nc(-c4ccc(C)o4)nc(N)c3n2)c1	10.1016/j.bmc.2016.04.048
	CHEMBL3800587	139548	0	None	-45	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	335	4	1	7	3.0	COc1cccc(Cn2cc3nc(-c4ccc(C)o4)nc(N)c3n2)c1	10.1016/j.bmc.2016.04.048
	56964576	74362	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	372	2	0	5	4.4	O=c1c(-c2ccccc2)nnc2n(-c3ccccc3)c3ccc(Cl)cc3n12	10.1021/jm201177b
	CHEMBL2030707	74362	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	372	2	0	5	4.4	O=c1c(-c2ccccc2)nnc2n(-c3ccccc3)c3ccc(Cl)cc3n12	10.1021/jm201177b
	44186626	184016	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL484900	184016	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	25207803	5594	0	None	10	4	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	381	6	2	8	4.0	CNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1077943	5594	0	None	10	4	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	381	6	2	8	4.0	CNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	10.1016/j.bmcl.2009.08.040
	44186669	185205	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486688	185205	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44186581	3144	23	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	10.1021/jm900413e
	6561	3144	23	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	10.1021/jm900413e
	CHEMBL482436	3144	23	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	10.1021/jm900413e
	53248699	62758	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	8	2	6	6.0	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760897	62758	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	8	2	6	6.0	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1789197	62758	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	8	2	6	6.0	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	4355631	192885	2	None	1	3	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	320	2	0	6	2.2	COC(=O)C1=C2C=CN(C)C=C2c2nc(-c3ccccc3)nn2C1	10.1021/jm990499b
	CHEMBL52735	192885	2	None	1	3	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	320	2	0	6	2.2	COC(=O)C1=C2C=CN(C)C=C2c2nc(-c3ccccc3)nn2C1	10.1021/jm990499b
	25230180	5866	0	None	2	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	4	1	6	3.5	C[C@@H](Nc1nc(C(=O)N2CCCC2)c2sccc2n1)c1cccnc1	10.1016/j.bmcl.2009.08.040
	CHEMBL1079893	5866	0	None	2	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	353	4	1	6	3.5	C[C@@H](Nc1nc(C(=O)N2CCCC2)c2sccc2n1)c1cccnc1	10.1016/j.bmcl.2009.08.040
	25231170	5425	0	None	8	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	327	5	2	6	2.8	CC(C)NC(=O)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1076504	5425	0	None	8	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	327	5	2	6	2.8	CC(C)NC(=O)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	57396935	69427	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	255	1	1	8	0.9	Cn1ncc2nc(N)n3nc(-c4ccco4)nc3c21	10.1016/j.bmc.2011.11.037
	CHEMBL1935752	69427	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	255	1	1	8	0.9	Cn1ncc2nc(N)n3nc(-c4ccco4)nc3c21	10.1016/j.bmc.2011.11.037
	132991405	150519	3	None	-6165	2	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	2	8	3.5	COc1ccccc1CNc1nc(N)c2nc(-c3ccco3)sc2n1	10.1021/acs.jmedchem.6b01068
	CHEMBL3958838	150519	3	None	-6165	2	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	2	8	3.5	COc1ccccc1CNc1nc(N)c2nc(-c3ccco3)sc2n1	10.1021/acs.jmedchem.6b01068
	118708239	112857	0	None	-109	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	345	5	2	6	3.3	Nc1nc(CCCc2cccc(O)c2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	CHEMBL3317579	112857	0	None	-109	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	345	5	2	6	3.3	Nc1nc(CCCc2cccc(O)c2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	57391694	69429	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	345	4	1	8	2.6	Nc1nc2cnn(CCc3ccccc3)c2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	CHEMBL1935754	69429	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	345	4	1	8	2.6	Nc1nc2cnn(CCc3ccccc3)c2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	57403904	69432	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	432	6	2	9	3.8	CCCn1ncc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c21	10.1016/j.bmc.2011.11.037
	CHEMBL1935757	69432	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	432	6	2	9	3.8	CCCn1ncc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c21	10.1016/j.bmc.2011.11.037
	57398676	69438	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	359	5	1	8	2.9	Nc1nc2cn(CCCc3ccccc3)nc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	CHEMBL1935763	69438	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	359	5	1	8	2.9	Nc1nc2cn(CCCc3ccccc3)nc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	25230949	5913	0	None	15	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	367	5	2	8	3.6	Nc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1080241	5913	0	None	15	4	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	367	5	2	8	3.6	Nc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	10.1016/j.bmcl.2009.08.040
	136042333	70801	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	514	8	2	9	3.4	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)c(F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955909	70801	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	514	8	2	9	3.4	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)c(F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	134147788	149447	0	None	-1	2	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	323	4	2	7	3.5	Nc1nc(NCc2ccccc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3950142	149447	0	None	-1	2	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	323	4	2	7	3.5	Nc1nc(NCc2ccccc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	71601630	86480	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting methodAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting method	ChEMBL	225	1	1	5	1.7	Cc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1016/j.ejmech.2015.11.015
	CHEMBL2322916	86480	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting methodAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting method	ChEMBL	225	1	1	5	1.7	Cc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1016/j.ejmech.2015.11.015
	71601630	86480	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	225	1	1	5	1.7	Cc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1016/j.bmc.2016.04.048
	CHEMBL2322916	86480	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	225	1	1	5	1.7	Cc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1016/j.bmc.2016.04.048
	71601630	86480	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	225	1	1	5	1.7	Cc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1016/j.ejmech.2014.07.060
	CHEMBL2322916	86480	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	225	1	1	5	1.7	Cc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1016/j.ejmech.2014.07.060
	44408316	75040	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	391	3	2	9	1.5	Cn1cc2c(nc(NC(=O)Nc3cccc[n+]3[O-])n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	CHEMBL203998	75040	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptorInhibition of NECA-stimulated cAMP accumulation in CHO cells expressing human adenosine A2B receptor	ChEMBL	391	3	2	9	1.5	Cn1cc2c(nc(NC(=O)Nc3cccc[n+]3[O-])n3nc(-c4ccco4)nc23)n1	10.1021/jm051147+
	10687707	109855	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	328	2	0	6	3.3	O=c1c(-c2ccco2)nnc2n(-c3ccccc3)c3ccccc3n12	10.1021/jm201177b
	CHEMBL324100	109855	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	328	2	0	6	3.3	O=c1c(-c2ccco2)nnc2n(-c3ccccc3)c3ccccc3n12	10.1021/jm201177b
	11716665	2240	29	None	1	2	Human	6.5	pIC50	=	6.5	Functional	Activity at human A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISAActivity at human A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	5617	2240	29	None	1	2	Human	6.5	pIC50	=	6.5	Functional	Activity at human A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISAActivity at human A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	CHEMBL375293	2240	29	None	1	2	Human	6.5	pIC50	=	6.5	Functional	Activity at human A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISAActivity at human A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	135522362	99546	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	472	8	1	10	0.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(C)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL286838	99546	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	472	8	1	10	0.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(C)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	134151346	151027	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	275	4	2	7	2.8	CCCNc1nc(N)c2nc(-c3ccco3)sc2n1	10.1021/acs.jmedchem.6b01068
	CHEMBL3963278	151027	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	275	4	2	7	2.8	CCCNc1nc(N)c2nc(-c3ccco3)sc2n1	10.1021/acs.jmedchem.6b01068
	60154742	76803	0	None	-39	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	501	4	3	10	2.5	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)Nc4ccncc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2071050	76803	0	None	-39	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	501	4	3	10	2.5	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)Nc4ccncc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2078766	76803	0	None	-39	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	501	4	3	10	2.5	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)Nc4ccncc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	60154740	76621	0	None	-95	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	544	6	3	10	2.8	COc1ccc(CNC(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1	10.1021/jm300323t
	CHEMBL2071049	76621	0	None	-95	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	544	6	3	10	2.8	COc1ccc(CNC(=O)N2CCC(NC(=O)Nc3nc4nn(C)cc4c4nc(-c5ccco5)nn34)CC2)cc1	10.1021/jm300323t
	57402161	69435	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	255	1	1	8	0.9	Cn1cc2nc(N)n3nc(-c4ccco4)nc3c2n1	10.1016/j.bmc.2011.11.037
	CHEMBL1935760	69435	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	255	1	1	8	0.9	Cn1cc2nc(N)n3nc(-c4ccco4)nc3c2n1	10.1016/j.bmc.2011.11.037
	10126989	10651	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	417	7	1	6	3.7	COCCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171526	10651	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	417	7	1	6	3.7	COCCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	145971923	162456	0	None	-1	2	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	324	4	2	8	2.9	Nc1nc(NCc2ccncc2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4175676	162456	0	None	-1	2	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	324	4	2	8	2.9	Nc1nc(NCc2ccncc2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	118708236	112854	0	None	-138	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	359	6	1	6	3.6	COc1cccc(CCCc2nc(N)c3nn(-c4ccccc4)cc3n2)c1	10.1016/j.ejmech.2014.07.060
	CHEMBL3317576	112854	0	None	-138	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	359	6	1	6	3.6	COc1cccc(CCCc2nc(N)c3nn(-c4ccccc4)cc3n2)c1	10.1016/j.ejmech.2014.07.060
	156017042	177174	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP levelInverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP level	ChEMBL	450	5	1	10	3.4	CCOC(=O)c1ccc(N2CCN(c3nc(N)c4nc(-c5ccco5)sc4n3)CC2)cc1	10.1016/j.bmcl.2020.127067
	CHEMBL4642713	177174	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP levelInverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP level	ChEMBL	450	5	1	10	3.4	CCOC(=O)c1ccc(N2CCN(c3nc(N)c4nc(-c5ccco5)sc4n3)CC2)cc1	10.1016/j.bmcl.2020.127067
	156010442	176459	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP productionInhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP production	ChEMBL	416	6	3	9	2.2	Nc1nc(NCCc2ccc(S(N)(=O)=O)cc2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	CHEMBL4632532	176459	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP productionInhibition of human A2B receptor expressed in CHO cells assessed as reduction in cAMP production	ChEMBL	416	6	3	9	2.2	Nc1nc(NCCc2ccc(S(N)(=O)=O)cc2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	11716665	2240	29	None	-1	2	Mouse	6.5	pIC50	=	6.5	Functional	Activity at mouse A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISAActivity at mouse A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	5617	2240	29	None	-1	2	Mouse	6.5	pIC50	=	6.5	Functional	Activity at mouse A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISAActivity at mouse A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	CHEMBL375293	2240	29	None	-1	2	Mouse	6.5	pIC50	=	6.5	Functional	Activity at mouse A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISAActivity at mouse A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced intracellular cAMP levels by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	49797793	10738	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	427	6	1	7	3.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)OC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172274	10738	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	427	6	1	7	3.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)OC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	136042329	70796	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	534	10	2	11	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(=O)OCC)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955904	70796	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	534	10	2	11	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(=O)OCC)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	22283414	10548	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	359	4	2	5	3.7	COc1ccc(NC(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170518	10548	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	359	4	2	5	3.7	COc1ccc(NC(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	49797825	10551	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	430	6	2	6	2.8	CNC(=O)CN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170525	10551	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	430	6	2	6	2.8	CNC(=O)CN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	22283414	10548	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	359	4	2	5	3.7	COc1ccc(NC(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1170518	10548	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	359	4	2	5	3.7	COc1ccc(NC(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2011.02.053
	145961997	160995	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	301	4	2	7	2.6	COc1cccc(CNc2nc(N)c3nc(C)sc3n2)c1	10.1016/j.bmc.2018.05.048
	CHEMBL4128787	160995	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	301	4	2	7	2.6	COc1cccc(CNc2nc(N)c3nc(C)sc3n2)c1	10.1016/j.bmc.2018.05.048
	127045699	139092	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	323	3	1	6	3.2	Cc1ccc(-c2nc(N)c3nn(Cc4ccccc4F)cc3n2)o1	10.1016/j.bmc.2016.04.048
	CHEMBL3797666	139092	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	323	3	1	6	3.2	Cc1ccc(-c2nc(N)c3nn(Cc4ccccc4F)cc3n2)o1	10.1016/j.bmc.2016.04.048
	145963230	160948	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	333	4	2	6	3.9	Nc1nc(NCc2ccccc2)nc2sc(-c3ccccc3)nc12	10.1016/j.bmc.2018.05.048
	CHEMBL4128138	160948	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	333	4	2	6	3.9	Nc1nc(NCc2ccccc2)nc2sc(-c3ccccc3)nc12	10.1016/j.bmc.2018.05.048
	49797795	10501	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	447	6	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(S(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170129	10501	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	447	6	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(S(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	25230951	149754	0	None	5	4	Human	7.4	pIC50	=	7.4	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	380	6	1	7	4.6	CCc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	CHEMBL3952824	149754	0	None	5	4	Human	7.4	pIC50	=	7.4	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	380	6	1	7	4.6	CCc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	45481750	196877	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	449	5	1	8	4.0	Cn1cc2c(nc(NC(=O)C(c3ccccc3)c3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL578224	196877	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	449	5	1	8	4.0	Cn1cc2c(nc(NC(=O)C(c3ccccc3)c3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	46882996	5548	0	None	1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	288	3	0	5	3.9	CCc1nc(C(=O)c2ccc(C)s2)c2sccc2n1	10.1016/j.bmcl.2009.08.040
	CHEMBL1077750	5548	0	None	1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	288	3	0	5	3.9	CCc1nc(C(=O)c2ccc(C)s2)c2sccc2n1	10.1016/j.bmcl.2009.08.040
	49797774	10507	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	462	7	2	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(NS(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170137	10507	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	462	7	2	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(NS(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	145961339	161005	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	257	2	2	6	2.7	Cc1nc2c(N)nc(Nc3ccccc3)nc2s1	10.1016/j.bmc.2018.05.048
	CHEMBL4128862	161005	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	257	2	2	6	2.7	Cc1nc2c(N)nc(Nc3ccccc3)nc2s1	10.1016/j.bmc.2018.05.048
	49798139	10557	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	495	6	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCN(C)CC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170583	10557	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	495	6	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCN(C)CC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	135484064	2568	3	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	390	2568	3	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	CHEMBL260331	2568	3	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	136042353	70794	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	530	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(F)(F)F)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955902	70794	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	530	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(F)(F)F)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	135484064	2568	3	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	390	2568	3	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	CHEMBL260331	2568	3	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	118708235	112853	0	None	-32	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	359	6	1	6	3.6	COc1ccccc1CCCc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1016/j.ejmech.2014.07.060
	CHEMBL3317575	112853	0	None	-32	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	359	6	1	6	3.6	COc1ccccc1CCCc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1016/j.ejmech.2014.07.060
	134149255	147620	0	None	-16	2	Human	6.4	pIC50	=	6.4	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	2	7	3.6	Nc1nc(NCCc2ccccc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3935610	147620	0	None	-16	2	Human	6.4	pIC50	=	6.4	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	2	7	3.6	Nc1nc(NCCc2ccccc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	145954398	162033	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	367	5	2	8	3.9	COc1ccccc1CNc1nc(N)c2nc(-c3ccc(C)o3)sc2n1	10.1016/j.ejmech.2018.06.020
	CHEMBL4168980	162033	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	367	5	2	8	3.9	COc1ccccc1CNc1nc(N)c2nc(-c3ccc(C)o3)sc2n1	10.1016/j.ejmech.2018.06.020
	25230881	6085	0	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	395	6	1	8	4.1	CN(C)c1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1081160	6085	0	None	1	4	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	395	6	1	8	4.1	CN(C)c1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	10.1016/j.bmcl.2009.08.040
	127045909	139445	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	321	3	2	7	2.7	Cc1ccc(-c2nc(N)c3nn(Cc4ccccc4O)cc3n2)o1	10.1016/j.bmc.2016.04.048
	CHEMBL3799921	139445	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	321	3	2	7	2.7	Cc1ccc(-c2nc(N)c3nn(Cc4ccccc4O)cc3n2)o1	10.1016/j.bmc.2016.04.048
	156821369	185031	2	None	-14	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	447	4	2	7	3.5	Nc1nc(-c2ccccc2)c(-c2ccc(=O)[nH]c2)c2nc(Cc3ncc(F)cc3Cl)nn12	10.1021/acsmedchemlett.1c00620
	CHEMBL4864129	185031	2	None	-14	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	447	4	2	7	3.5	Nc1nc(-c2ccccc2)c(-c2ccc(=O)[nH]c2)c2nc(Cc3ncc(F)cc3Cl)nn12	10.1021/acsmedchemlett.1c00620
	145436763	161636	0	None	-13	2	Human	8.4	pIC50	=	8.4	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	338	5	2	8	3.0	Nc1nc(NCCc2cccnc2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4162638	161636	0	None	-13	2	Human	8.4	pIC50	=	8.4	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	338	5	2	8	3.0	Nc1nc(NCCc2cccnc2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	44186579	191178	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	494	6	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL519813	191178	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	494	6	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	57400352	69428	0	None	12	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	283	3	1	8	1.7	CCCn1ncc2nc(N)n3nc(-c4ccco4)nc3c21	10.1016/j.bmc.2011.11.037
	CHEMBL1935753	69428	0	None	12	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	283	3	1	8	1.7	CCCn1ncc2nc(N)n3nc(-c4ccco4)nc3c21	10.1016/j.bmc.2011.11.037
	49797855	10734	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	441	5	1	5	4.6	COc1ccc(N(CC(F)(F)F)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172269	10734	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	441	5	1	5	4.6	COc1ccc(N(CC(F)(F)F)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	135522368	489	1	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	383	489	1	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	CHEMBL33491	489	1	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	11371101	67211	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human cloned adenosine A2B cells expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP productionAntagonist activity at human cloned adenosine A2B cells expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production	ChEMBL	336	4	0	6	2.2	CCCn1c(=O)c2c(nc3n2CC(C)=C3)n(Cc2ccccc2)c1=O	10.1016/j.bmc.2008.10.049
	CHEMBL189904	67211	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human cloned adenosine A2B cells expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP productionAntagonist activity at human cloned adenosine A2B cells expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production	ChEMBL	336	4	0	6	2.2	CCCn1c(=O)c2c(nc3n2CC(C)=C3)n(Cc2ccccc2)c1=O	10.1016/j.bmc.2008.10.049
	11371101	67211	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of 100 nM NECA-stimulated cAMP production in CHO cells expressing human adenosine A2B receptorInhibition of 100 nM NECA-stimulated cAMP production in CHO cells expressing human adenosine A2B receptor	ChEMBL	336	4	0	6	2.2	CCCn1c(=O)c2c(nc3n2CC(C)=C3)n(Cc2ccccc2)c1=O	10.1021/jm058008c
	CHEMBL189904	67211	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of 100 nM NECA-stimulated cAMP production in CHO cells expressing human adenosine A2B receptorInhibition of 100 nM NECA-stimulated cAMP production in CHO cells expressing human adenosine A2B receptor	ChEMBL	336	4	0	6	2.2	CCCn1c(=O)c2c(nc3n2CC(C)=C3)n(Cc2ccccc2)c1=O	10.1021/jm058008c
	145961748	160952	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	365	5	2	9	2.7	COc1ccccc1CNc1nc(N)c2nc(-c3cnccn3)sc2n1	10.1016/j.bmc.2018.05.048
	CHEMBL4128190	160952	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	365	5	2	9	2.7	COc1ccccc1CNc1nc(N)c2nc(-c3cnccn3)sc2n1	10.1016/j.bmc.2018.05.048
	54586036	60385	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	6	1	6	4.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CCN(C(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760887	60385	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	6	1	6	4.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CCN(C(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	10761800	187626	0	None	-5	2	Rat	6.4	pIC50	=	6.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	372	1	2	7	2.5	Cn1c(-c2cccc(C#N)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL49925	187626	0	None	-5	2	Rat	6.4	pIC50	=	6.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	372	1	2	7	2.5	Cn1c(-c2cccc(C#N)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	46883041	5641	0	None	2	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	379	5	1	6	5.5	Cc1ccc(C(=O)c2nc(NC(C)c3ccccc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1078347	5641	0	None	2	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	379	5	1	6	5.5	Cc1ccc(C(=O)c2nc(NC(C)c3ccccc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	46883074	5614	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	5	0	7	4.3	Cc1ccc(C(=O)c2nc(N(C)Cc3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1078087	5614	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	5	0	7	4.3	Cc1ccc(C(=O)c2nc(N(C)Cc3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	57402117	69417	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	254	1	1	7	1.5	Cn1cc2nc(N)n3nc(-c4ccco4)nc3c2c1	10.1016/j.bmc.2011.11.037
	CHEMBL1935743	69417	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	254	1	1	7	1.5	Cn1cc2nc(N)n3nc(-c4ccco4)nc3c2c1	10.1016/j.bmc.2011.11.037
	49797852	10649	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	417	7	2	6	3.4	COc1ccc(N(CCCO)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171524	10649	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	417	7	2	6	3.4	COc1ccc(N(CCCO)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	54587015	60383	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	570	7	1	7	4.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CCN(S(=O)(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760885	60383	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	570	7	1	7	4.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CCN(S(=O)(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	71601632	86482	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting methodAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting method	ChEMBL	301	3	1	5	3.0	Nc1nc(Cc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2015.11.015
	CHEMBL2322918	86482	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting methodAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting method	ChEMBL	301	3	1	5	3.0	Nc1nc(Cc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2015.11.015
	71601632	86482	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	301	3	1	5	3.0	Nc1nc(Cc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.bmc.2016.04.048
	CHEMBL2322918	86482	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	301	3	1	5	3.0	Nc1nc(Cc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.bmc.2016.04.048
	71601632	86482	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	301	3	1	5	3.0	Nc1nc(Cc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	CHEMBL2322918	86482	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	301	3	1	5	3.0	Nc1nc(Cc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	9841364	100974	1	None	-6	2	Rat	6.4	pIC50	=	6.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	351	1	2	6	2.4	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCC3)nc21	10.1021/jm990499b
	CHEMBL297685	100974	1	None	-6	2	Rat	6.4	pIC50	=	6.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	351	1	2	6	2.4	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCC3)nc21	10.1021/jm990499b
	127045700	139179	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	323	3	1	6	3.2	Cc1ccc(-c2nc(N)c3nn(Cc4cccc(F)c4)cc3n2)o1	10.1016/j.bmc.2016.04.048
	CHEMBL3798214	139179	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	323	3	1	6	3.2	Cc1ccc(-c2nc(N)c3nn(Cc4cccc(F)c4)cc3n2)o1	10.1016/j.bmc.2016.04.048
	1329	1439	78	None	-9	8	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayAntagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assay	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.9b00106
	386	1439	78	None	-9	8	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayAntagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assay	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.9b00106
	CHEMBL183	1439	78	None	-9	8	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayAntagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assay	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.9b00106
	DB12946	1439	78	None	-9	8	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assayAntagonist activity at human A2BR expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by alphascreen assay	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.9b00106
	135678052	95320	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	483	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Cl)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL258571	95320	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	483	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Cl)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	46883042	5642	0	None	4	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	366	5	1	7	4.3	Cc1ccc(C(=O)c2nc(NCc3ccccn3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1078348	5642	0	None	4	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	366	5	1	7	4.3	Cc1ccc(C(=O)c2nc(NCc3ccccn3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	136042347	70816	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	482	9	2	8	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955925	70816	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	482	9	2	8	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	118708234	112852	0	None	-10	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	329	5	1	5	3.6	Nc1nc(CCCc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	CHEMBL3317574	112852	0	None	-10	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	329	5	1	5	3.6	Nc1nc(CCCc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	127035626	136781	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	426	6	3	8	4.0	O=C(Nc1ccccc1)Nc1nc(NCc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.ejmech.2015.12.019
	CHEMBL3752621	136781	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	426	6	3	8	4.0	O=C(Nc1ccccc1)Nc1nc(NCc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.ejmech.2015.12.019
	145960873	160885	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	347	5	2	6	4.0	Nc1nc(NCCc2ccccc2)nc2sc(-c3ccccc3)nc12	10.1016/j.bmc.2018.05.048
	CHEMBL4127351	160885	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	347	5	2	6	4.0	Nc1nc(NCCc2ccccc2)nc2sc(-c3ccccc3)nc12	10.1016/j.bmc.2018.05.048
	54580150	60391	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	7	1	6	5.5	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)C3CCN(Cc4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760894	60391	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	534	7	1	6	5.5	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)C3CCN(Cc4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	71601631	86481	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting methodAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting method	ChEMBL	287	2	1	5	3.1	Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2015.11.015
	CHEMBL2322917	86481	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting methodAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP production by scintillation counting method	ChEMBL	287	2	1	5	3.1	Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2015.11.015
	71601631	86481	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	287	2	1	5	3.1	Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.bmc.2016.04.048
	CHEMBL2322917	86481	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	287	2	1	5	3.1	Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.bmc.2016.04.048
	71601631	86481	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	287	2	1	5	3.1	Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	CHEMBL2322917	86481	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	287	2	1	5	3.1	Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	10691124	100798	0	None	-8	2	Rat	6.4	pIC50	=	6.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	379	1	2	6	3.2	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCCCC3)nc21	10.1021/jm990499b
	CHEMBL296389	100798	0	None	-8	2	Rat	6.4	pIC50	=	6.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	379	1	2	6	3.2	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCCCC3)nc21	10.1021/jm990499b
	10618828	101505	0	None	-5	2	Rat	6.4	pIC50	=	6.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	365	1	2	6	2.8	Cn1c(-c2ccccc2F)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL301512	101505	0	None	-5	2	Rat	6.4	pIC50	=	6.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	365	1	2	6	2.8	Cn1c(-c2ccccc2F)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	10754589	192707	0	None	-	1	Rat	5.4	pIC50	=	5.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	271	0	2	6	1.0	Cn1cnc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL52432	192707	0	None	-	1	Rat	5.4	pIC50	=	5.4	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	271	0	2	6	1.0	Cn1cnc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	57396936	69436	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	283	3	1	8	1.7	CCCn1cc2nc(N)n3nc(-c4ccco4)nc3c2n1	10.1016/j.bmc.2011.11.037
	CHEMBL1935761	69436	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	283	3	1	8	1.7	CCCn1cc2nc(N)n3nc(-c4ccco4)nc3c2n1	10.1016/j.bmc.2011.11.037
	136042354	70795	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	476	8	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955903	70795	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	476	8	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	46883073	5613	0	None	-2	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	6	1	7	4.3	Cc1ccc(C(=O)c2nc(NCCc3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1078086	5613	0	None	-2	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	6	1	7	4.3	Cc1ccc(C(=O)c2nc(NCCc3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	132991406	143669	0	None	-4786	2	Human	6.3	pIC50	=	6.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	2	8	3.5	COc1cccc(CNc2nc(N)c3nc(-c4ccco4)sc3n2)c1	10.1021/acs.jmedchem.6b01068
	CHEMBL3904408	143669	0	None	-4786	2	Human	6.3	pIC50	=	6.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	2	8	3.5	COc1cccc(CNc2nc(N)c3nc(-c4ccco4)sc3n2)c1	10.1021/acs.jmedchem.6b01068
	145958464	161598	0	None	-1174	2	Human	5.3	pIC50	=	5.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	369	5	2	8	4.0	COc1ccccc1CNc1nc(N)c2nc(-c3cccs3)sc2n1	10.1016/j.ejmech.2018.06.020
	CHEMBL4162037	161598	0	None	-1174	2	Human	5.3	pIC50	=	5.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	369	5	2	8	4.0	COc1ccccc1CNc1nc(N)c2nc(-c3cccs3)sc2n1	10.1016/j.ejmech.2018.06.020
	57396888	69419	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	344	4	1	7	3.2	Nc1nc2cn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	CHEMBL1935745	69419	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	344	4	1	7	3.2	Nc1nc2cn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	135522375	113745	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	525	11	2	11	2.1	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)c(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33305	113745	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	525	11	2	11	2.1	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)c(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	46883109	5742	0	None	2	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	350	5	1	7	3.8	Cc1ccc(C(=O)c2nc(NCc3cccnc3)nc3ccsc23)o1	10.1016/j.bmcl.2009.08.040
	CHEMBL1079117	5742	0	None	2	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	350	5	1	7	3.8	Cc1ccc(C(=O)c2nc(NCc3cccnc3)nc3ccsc23)o1	10.1016/j.bmcl.2009.08.040
	134132667	144038	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	367	6	2	8	3.6	COc1cccc(CCNc2nc(N)c3nc(-c4ccco4)sc3n2)c1	10.1021/acs.jmedchem.6b01068
	CHEMBL3907658	144038	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	367	6	2	8	3.6	COc1cccc(CCNc2nc(N)c3nc(-c4ccco4)sc3n2)c1	10.1021/acs.jmedchem.6b01068
	10175278	169805	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	588	9	2	8	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)nc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL444787	169805	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	588	9	2	8	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)nc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL5075422	212591	2	None	-83	4	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human recombinant adenosine A2B receptor transfected in HEK293 cells co-transfected with Galpha15/16 assessed as intracellular calcium change incubated for 10 mins by microplate reader methodAntagonist activity at human recombinant adenosine A2B receptor transfected in HEK293 cells co-transfected with Galpha15/16 assessed as intracellular calcium change incubated for 10 mins by microplate reader method	ChEMBL		None	None	None		Cn1cc(-c2cnc(N)n3nc(-c4ccco4)nc23)ccc1=O	10.1021/acsmedchemlett.1c00599
	176407	4069	76	None	-13	2	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.6b01068
	405	4069	76	None	-13	2	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.6b01068
	CHEMBL113142	4069	76	None	-13	2	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.6b01068
	DB08770	4069	76	None	-13	2	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.6b01068
	134132684	144175	0	None	-20	2	Human	6.3	pIC50	=	6.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	3	8	3.3	Nc1nc(NCCc2ccc(O)cc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3908770	144175	0	None	-20	2	Human	6.3	pIC50	=	6.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	353	5	3	8	3.3	Nc1nc(NCCc2ccc(O)cc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	46883108	5741	0	None	3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	386	5	1	7	4.6	O=C(c1ccc(Cl)s1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1079116	5741	0	None	3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	386	5	1	7	4.6	O=C(c1ccc(Cl)s1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	54584125	60390	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	584	7	1	7	4.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)C3CCN(S(=O)(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760893	60390	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	584	7	1	7	4.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)C3CCN(S(=O)(=O)c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	10691124	100798	0	None	8	2	Human	7.3	pIC50	=	7.3	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	379	1	2	6	3.2	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCCCC3)nc21	10.1021/jm990499b
	CHEMBL296389	100798	0	None	8	2	Human	7.3	pIC50	=	7.3	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	379	1	2	6	3.2	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCCCC3)nc21	10.1021/jm990499b
	46237928	8706	0	None	-42	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	329	3	1	5	3.3	Cn1cc2c(NC(=O)c3ccccc3)nc(-c3ccccc3)nc2n1	10.1021/jm901785w
	CHEMBL1096754	8706	0	None	-42	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	329	3	1	5	3.3	Cn1cc2c(NC(=O)c3ccccc3)nc(-c3ccccc3)nc2n1	10.1021/jm901785w
	10762430	188561	0	None	-	1	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	381	1	2	6	3.3	Cn1c(-c2cccc(Cl)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL51107	188561	0	None	-	1	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	381	1	2	6	3.3	Cn1c(-c2cccc(Cl)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	45481754	196464	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	477	7	1	8	4.9	CCCn1cc2c(nc(NC(=O)C(c3ccccc3)c3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL574775	196464	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	477	7	1	8	4.9	CCCn1cc2c(nc(NC(=O)C(c3ccccc3)c3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	25230098	6124	0	None	14	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	299	4	2	6	2.1	CNC(=O)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1081334	6124	0	None	14	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	299	4	2	6	2.1	CNC(=O)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	156010442	176459	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP levelInverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP level	ChEMBL	416	6	3	9	2.2	Nc1nc(NCCc2ccc(S(N)(=O)=O)cc2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	CHEMBL4632532	176459	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP levelInverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP level	ChEMBL	416	6	3	9	2.2	Nc1nc(NCCc2ccc(S(N)(=O)=O)cc2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	44186716	183522	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	524	7	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL482648	183522	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	524	7	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44186718	183581	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	538	6	2	9	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL483065	183581	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2	ChEMBL	538	6	2	9	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	57325914	74361	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	356	4	0	6	3.5	O=c1c(-c2ccco2)nnc2n(CCc3ccccc3)c3ccccc3n12	10.1021/jm201177b
	CHEMBL2030706	74361	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	356	4	0	6	3.5	O=c1c(-c2ccco2)nnc2n(CCc3ccccc3)c3ccccc3n12	10.1021/jm201177b
	10714900	188850	0	None	12	2	Human	6.3	pIC50	=	6.3	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	381	1	2	6	3.3	Cn1c(-c2ccc(Cl)cc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL51353	188850	0	None	12	2	Human	6.3	pIC50	=	6.3	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	381	1	2	6	3.3	Cn1c(-c2ccc(Cl)cc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	45482074	196615	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	511	8	1	8	5.2	O=C(Cc1cccc(Cl)c1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2009.05.038
	CHEMBL576017	196615	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	511	8	1	8	5.2	O=C(Cc1cccc(Cl)c1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2009.05.038
	145960746	161044	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	365	5	2	9	2.7	COc1cccc(CNc2nc(N)c3nc(-c4cnccn4)sc3n2)c1	10.1016/j.bmc.2018.05.048
	CHEMBL4129565	161044	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	365	5	2	9	2.7	COc1cccc(CNc2nc(N)c3nc(-c4cnccn4)sc3n2)c1	10.1016/j.bmc.2018.05.048
	60154738	76619	0	None	-5	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	548	5	3	9	3.4	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccc(Cl)cc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL2071047	76619	0	None	-5	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	548	5	3	9	3.4	Cn1cc2c(nc(NC(=O)NC3CCN(C(=O)NCc4ccc(Cl)cc4)CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	45482464	196845	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	447	7	1	8	4.1	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL578005	196845	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	447	7	1	8	4.1	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	136042341	70808	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	517	8	2	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(F)(F)F)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955917	70808	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	517	8	2	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(F)(F)F)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	176407	4069	76	None	-13	2	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.ejmech.2018.06.020
	405	4069	76	None	-13	2	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.ejmech.2018.06.020
	CHEMBL113142	4069	76	None	-13	2	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.ejmech.2018.06.020
	DB08770	4069	76	None	-13	2	Human	7.3	pIC50	=	7.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.ejmech.2018.06.020
	10616023	101379	0	None	-3	2	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	325	1	2	6	1.9	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC(C)(C)O)nc21	10.1021/jm990499b
	CHEMBL300624	101379	0	None	-3	2	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	325	1	2	6	1.9	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC(C)(C)O)nc21	10.1021/jm990499b
	46883158	5746	0	None	3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	346	5	1	6	3.9	O=C(c1ccccc1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1079141	5746	0	None	3	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	346	5	1	6	3.9	O=C(c1ccccc1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	127046493	139254	0	None	-83	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	321	4	1	7	2.7	COc1ccccc1Cn1cc2nc(-c3ccco3)nc(N)c2n1	10.1016/j.bmc.2016.04.048
	CHEMBL3798766	139254	0	None	-83	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	321	4	1	7	2.7	COc1ccccc1Cn1cc2nc(-c3ccco3)nc(N)c2n1	10.1016/j.bmc.2016.04.048
	16071896	57704	37	None	-4	2	Mouse	6.3	pIC50	=	6.3	Functional	Antagonist activity at mouse adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced increase of intracellular cAMP level after 30 mins by ELISAAntagonist activity at mouse adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced increase of intracellular cAMP level after 30 mins by ELISA	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672627	57704	37	None	-4	2	Mouse	6.3	pIC50	=	6.3	Functional	Antagonist activity at mouse adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced increase of intracellular cAMP level after 30 mins by ELISAAntagonist activity at mouse adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced increase of intracellular cAMP level after 30 mins by ELISA	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	25230950	152201	0	None	3	4	Human	7.3	pIC50	=	7.3	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	378	6	1	7	4.6	C=Cc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	CHEMBL3973260	152201	0	None	3	4	Human	7.3	pIC50	=	7.3	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	378	6	1	7	4.6	C=Cc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	136042334	70802	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	490	8	2	9	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C)c(C)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955910	70802	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	490	8	2	9	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C)c(C)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	46237929	8853	0	None	-138	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	359	4	1	6	3.3	COc1ccc(C(=O)Nc2nc(-c3ccccc3)nc3nn(C)cc23)cc1	10.1021/jm901785w
	CHEMBL1098108	8853	0	None	-138	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometryAntagonist activity human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated [3H]cAMP accumulation treated 15 mins before NECA challenge measured after 30 mins by liquid scintillation spectrometry	ChEMBL	359	4	1	6	3.3	COc1ccc(C(=O)Nc2nc(-c3ccccc3)nc3nn(C)cc23)cc1	10.1021/jm901785w
	10633978	185285	0	None	-	1	Rat	5.3	pIC50	=	5.3	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	243	1	1	5	1.8	Cn1c(-c2cccc(F)c2)nc2c(N)ncnc21	10.1021/jm990499b
	CHEMBL48682	185285	0	None	-	1	Rat	5.3	pIC50	=	5.3	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	243	1	1	5	1.8	Cn1c(-c2cccc(F)c2)nc2c(N)ncnc21	10.1021/jm990499b
	45482080	196738	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	451	6	1	8	4.5	CCCn1cc2c(nc(NC(=O)Cc3ccc4ccccc4c3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL577135	196738	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	451	6	1	8	4.5	CCCn1cc2c(nc(NC(=O)Cc3ccc4ccccc4c3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	46882994	5733	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	260	2	0	5	3.3	Cc1ccc(C(=O)c2ncnc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1079059	5733	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	260	2	0	5	3.3	Cc1ccc(C(=O)c2ncnc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	136042351	70792	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	492	9	2	10	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(OC)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955900	70792	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	492	9	2	10	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(OC)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	386674	110820	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	352	3	0	5	3.8	O=c1c(-c2ccccc2)nnc2n(Cc3ccccc3)c3ccccc3n12	10.1021/jm201177b
	CHEMBL326752	110820	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	352	3	0	5	3.8	O=c1c(-c2ccccc2)nnc2n(Cc3ccccc3)c3ccccc3n12	10.1021/jm201177b
	10665761	188677	0	None	-3	2	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	353	3	2	6	2.7	CCC(O)(C#Cc1nc(N)c2nc(-c3cccc(F)c3)n(C)c2n1)CC	10.1021/jm990499b
	CHEMBL51192	188677	0	None	-3	2	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	353	3	2	6	2.7	CCC(O)(C#Cc1nc(N)c2nc(-c3cccc(F)c3)n(C)c2n1)CC	10.1021/jm990499b
	145954098	161977	0	None	-35	2	Human	6.3	pIC50	=	6.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	345	4	2	8	4.1	Nc1nc(NCc2cccs2)nc2sc(-c3cccs3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4168016	161977	0	None	-35	2	Human	6.3	pIC50	=	6.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	345	4	2	8	4.1	Nc1nc(NCc2cccs2)nc2sc(-c3cccs3)nc12	10.1016/j.ejmech.2018.06.020
	57402162	69441	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	494	7	2	9	4.6	COc1ccc(NC(=O)Nc2nc3cn(CCc4ccccc4)nc3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	CHEMBL1935766	69441	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	494	7	2	9	4.6	COc1ccc(NC(=O)Nc2nc3cn(CCc4ccccc4)nc3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	44537897	196389	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	497	7	1	8	5.0	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL574263	196389	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	497	7	1	8	5.0	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	46883043	5643	0	None	18	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	366	5	1	7	4.3	Cc1ccc(C(=O)c2nc(NCc3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1078349	5643	0	None	18	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	366	5	1	7	4.3	Cc1ccc(C(=O)c2nc(NCc3cccnc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	134138322	147495	0	None	-15	2	Human	6.3	pIC50	=	6.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	367	6	2	8	3.6	COc1ccc(CCNc2nc(N)c3nc(-c4ccco4)sc3n2)cc1	10.1021/acs.jmedchem.6b01068
	CHEMBL3934626	147495	0	None	-15	2	Human	6.3	pIC50	=	6.3	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	367	6	2	8	3.6	COc1ccc(CCNc2nc(N)c3nc(-c4ccco4)sc3n2)cc1	10.1021/acs.jmedchem.6b01068
	145963661	160982	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	301	4	2	7	2.6	COc1ccccc1CNc1nc(N)c2nc(C)sc2n1	10.1016/j.bmc.2018.05.048
	CHEMBL4128638	160982	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	301	4	2	7	2.6	COc1ccccc1CNc1nc(N)c2nc(C)sc2n1	10.1016/j.bmc.2018.05.048
	46883040	5596	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	365	5	1	6	4.9	Cc1ccc(C(=O)c2nc(NCc3ccccc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1077985	5596	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	365	5	1	6	4.9	Cc1ccc(C(=O)c2nc(NCc3ccccc3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	10621771	192507	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	415	1	2	6	3.7	Cn1c(-c2cccc(C(F)(F)F)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL52276	192507	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	415	1	2	6	3.7	Cn1c(-c2cccc(C(F)(F)F)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	25230100	6260	0	None	5	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	367	5	2	6	3.8	O=C(NC1CCCCC1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1082063	6260	0	None	5	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	367	5	2	6	3.8	O=C(NC1CCCCC1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	9970667	203560	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	276	1	0	5	2.2	Cn1c2ccccc2n2c(=O)c(-c3ccccc3)nnc12	10.1021/jm201177b
	CHEMBL7909	203560	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	276	1	0	5	2.2	Cn1c2ccccc2n2c(=O)c(-c3ccccc3)nnc12	10.1021/jm201177b
	135874413	95930	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	449	8	2	8	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccccc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL261810	95930	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	449	8	2	8	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccccc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	156018440	177268	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP levelInverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP level	ChEMBL	457	4	2	10	1.9	Nc1nc(N2CCN(c3ccc(S(N)(=O)=O)cc3)CC2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	CHEMBL4644153	177268	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP levelInverse agonist activity at human A2B receptor expressed in CHO cells assessed as reduction in cAMP level	ChEMBL	457	4	2	10	1.9	Nc1nc(N2CCN(c3ccc(S(N)(=O)=O)cc3)CC2)nc2sc(-c3ccco3)nc12	10.1016/j.bmcl.2020.127067
	57395164	69439	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3cn(C)nc3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	CHEMBL1935764	69439	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3cn(C)nc3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	45481760	196321	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	539	8	1	8	5.7	O=C(Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.05.038
	CHEMBL573780	196321	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	539	8	1	8	5.7	O=C(Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2009.05.038
	57395162	69430	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	359	5	1	8	2.9	Nc1nc2cnn(CCCc3ccccc3)c2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	CHEMBL1935755	69430	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	359	5	1	8	2.9	Nc1nc2cnn(CCCc3ccccc3)c2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2011.11.037
	49797905	10628	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	517	7	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(C(F)(F)F)c4)c3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171164	10628	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	517	7	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(C(F)(F)F)c4)c3)sc12	10.1016/j.bmcl.2010.05.056
	49797905	10628	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	517	7	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(C(F)(F)F)c4)c3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1171164	10628	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	517	7	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(C(F)(F)F)c4)c3)sc12	10.1016/j.bmcl.2011.02.053
	136042339	70806	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	483	8	2	9	3.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955915	70806	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	483	8	2	9	3.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	25230881	6085	0	None	1	4	Human	8.2	pIC50	=	8.2	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	395	6	1	8	4.1	CN(C)c1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	CHEMBL1081160	6085	0	None	1	4	Human	8.2	pIC50	=	8.2	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	395	6	1	8	4.1	CN(C)c1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	25230948	5943	0	None	3	4	Human	8.2	pIC50	=	8.2	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	395	7	2	8	4.4	CCNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	CHEMBL1080421	5943	0	None	3	4	Human	8.2	pIC50	=	8.2	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	395	7	2	8	4.4	CCNc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	156821433	185402	0	None	-12	2	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	427	4	1	8	2.9	Cn1cc(-c2c(-c3ccccc3)nc(N)n3nc(Cc4ncccc4F)nc23)ccc1=O	10.1021/acsmedchemlett.1c00620
	CHEMBL4870159	185402	0	None	-12	2	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	427	4	1	8	2.9	Cn1cc(-c2c(-c3ccccc3)nc(N)n3nc(Cc4ncccc4F)nc23)ccc1=O	10.1021/acsmedchemlett.1c00620
	49797826	10552	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	416	6	2	6	2.5	COc1ccc(N(CC(N)=O)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170526	10552	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	416	6	2	6	2.5	COc1ccc(N(CC(N)=O)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	136042331	70798	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	476	8	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C)cccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955906	70798	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	476	8	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C)cccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	135489238	474	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	381	474	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	CHEMBL32802	474	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	49797797	10503	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	444	6	1	6	3.1	COc1ccc(N(CC(=O)N(C)C)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170131	10503	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	444	6	1	6	3.1	COc1ccc(N(CC(=O)N(C)C)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	49797827	10527	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	417	6	2	6	3.1	COc1ccc(N(CC(=O)O)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170295	10527	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	417	6	2	6	3.1	COc1ccc(N(CC(=O)O)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	135874420	160743	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	479	9	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(OC)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL412284	160743	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	479	9	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(OC)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	136042328	70788	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	507	9	2	11	2.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc([N+](=O)[O-])ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955894	70788	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	507	9	2	11	2.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc([N+](=O)[O-])ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	136042352	70793	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	540	8	2	9	3.3	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Br)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955901	70793	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	540	8	2	9	3.3	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Br)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	156821338	185227	0	None	-8	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	439	5	1	9	2.7	COc1ccc(Cc2nc3c(-c4ccc(=O)n(C)c4)c(-c4ccccc4)nc(N)n3n2)nc1	10.1021/acsmedchemlett.1c00620
	CHEMBL4867286	185227	0	None	-8	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	439	5	1	9	2.7	COc1ccc(Cc2nc3c(-c4ccc(=O)n(C)c4)c(-c4ccccc4)nc(N)n3n2)nc1	10.1021/acsmedchemlett.1c00620
	9841364	100974	1	None	6	2	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	351	1	2	6	2.4	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCC3)nc21	10.1021/jm990499b
	CHEMBL297685	100974	1	None	6	2	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	351	1	2	6	2.4	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3(O)CCCC3)nc21	10.1021/jm990499b
	118708214	112841	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	211	1	1	5	1.4	Nc1ncnc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	CHEMBL3317555	112841	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysisAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level by scintillation counting analysis	ChEMBL	211	1	1	5	1.4	Nc1ncnc2cn(-c3ccccc3)nc12	10.1016/j.ejmech.2014.07.060
	10714900	188850	0	None	-12	2	Rat	5.2	pIC50	=	5.2	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	381	1	2	6	3.3	Cn1c(-c2ccc(Cl)cc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL51353	188850	0	None	-12	2	Rat	5.2	pIC50	=	5.2	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	381	1	2	6	3.3	Cn1c(-c2ccc(Cl)cc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	134139825	145952	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	309	3	2	7	3.7	Nc1nc(Nc2ccccc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	CHEMBL3922410	145952	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	309	3	2	7	3.7	Nc1nc(Nc2ccccc2)nc2sc(-c3ccco3)nc12	10.1021/acs.jmedchem.6b01068
	127045910	139496	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	321	3	2	7	2.7	Cc1ccc(-c2nc(N)c3nn(Cc4cccc(O)c4)cc3n2)o1	10.1016/j.bmc.2016.04.048
	CHEMBL3800254	139496	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMPAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated for 10 mins followed by NECA stimulation by scintillation counting method in presence of [3H]-cyclic AMP	ChEMBL	321	3	2	7	2.7	Cc1ccc(-c2nc(N)c3nn(Cc4cccc(O)c4)cc3n2)o1	10.1016/j.bmc.2016.04.048
	136042344	70811	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	551	8	2	9	4.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(Cl)cc(C(F)(F)F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955920	70811	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	551	8	2	9	4.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(Cl)cc(C(F)(F)F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	11716665	2240	29	None	-1	2	Mouse	6.2	pIC50	=	6.2	Functional	Inhibition of NECA-induced IL6 production in Swiss mouse fibroblasts after 24 hrs by ELISAInhibition of NECA-induced IL6 production in Swiss mouse fibroblasts after 24 hrs by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	5617	2240	29	None	-1	2	Mouse	6.2	pIC50	=	6.2	Functional	Inhibition of NECA-induced IL6 production in Swiss mouse fibroblasts after 24 hrs by ELISAInhibition of NECA-induced IL6 production in Swiss mouse fibroblasts after 24 hrs by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	CHEMBL375293	2240	29	None	-1	2	Mouse	6.2	pIC50	=	6.2	Functional	Inhibition of NECA-induced IL6 production in Swiss mouse fibroblasts after 24 hrs by ELISAInhibition of NECA-induced IL6 production in Swiss mouse fibroblasts after 24 hrs by ELISA	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	45482087	196419	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	441	4	1	8	3.8	Cn1cc2c(nc(NC(=O)Cc3c(Cl)cccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL574490	196419	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	441	4	1	8	3.8	Cn1cc2c(nc(NC(=O)Cc3c(Cl)cccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	136042355	70789	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	462	8	2	9	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955897	70789	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	462	8	2	9	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	135443367	484	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	382	484	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	CHEMBL33455	484	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	135874416	95928	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	467	8	2	8	2.7	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(F)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL261809	95928	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	467	8	2	8	2.7	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(F)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	25230952	146007	0	None	3	4	Human	7.2	pIC50	=	7.2	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	458	8	2	9	5.0	O=C(c1cccs1)c1nc(NCc2cccnc2)nc2cc(NCc3cccnc3)sc12	nan
	CHEMBL3922797	146007	0	None	3	4	Human	7.2	pIC50	=	7.2	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	458	8	2	9	5.0	O=C(c1cccs1)c1nc(NCc2cccnc2)nc2cc(NCc3cccnc3)sc12	nan
	49797879	10549	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	358	5	2	5	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cc[nH]c3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170519	10549	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	358	5	2	5	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cc[nH]c3)sc12	10.1016/j.bmcl.2010.05.056
	25230949	5913	0	None	15	4	Human	8.2	pIC50	=	8.2	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	367	5	2	8	3.6	Nc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	CHEMBL1080241	5913	0	None	15	4	Human	8.2	pIC50	=	8.2	Functional	Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.Fluorometric Imaging Plate Reader (FLIPR) Asssay: The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique. In this assay calcium flux is triggered by receptor activation and measured through the fluorescence of an incorporated calcium-sensitive dye. The potencies shown were determined using expressed human adenosine A2B receptors in mammalian cell lines. Selectivity values were obtained by using mammalian cell lines expressing the human adenosine A1, A2A and A3 receptors.	ChEMBL	367	5	2	8	3.6	Nc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1	nan
	136042332	70800	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	598	8	2	9	4.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C(F)(F)F)cc(C(F)(F)F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955908	70800	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	598	8	2	9	4.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C(F)(F)F)cc(C(F)(F)F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	135443367	484	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	382	484	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	CHEMBL33455	484	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	51051251	68932	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	321	3	2	8	1.6	Nc1nc(NC(=O)c2ccccc2)n2nc(-c3ccco3)nc2n1	10.1021/jm101349u
	CHEMBL1927634	68932	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	321	3	2	8	1.6	Nc1nc(NC(=O)c2ccccc2)n2nc(-c3ccco3)nc2n1	10.1021/jm101349u
	51050844	68905	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	442	6	3	10	3.1	CC(C)(C)OC(=O)NCC1CCC(CNc2nc(N)n3nc(-c4ccco4)nc3n2)CC1	10.1021/jm101349u
	CHEMBL1927427	68905	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	442	6	3	10	3.1	CC(C)(C)OC(=O)NCC1CCC(CNc2nc(N)n3nc(-c4ccco4)nc3n2)CC1	10.1021/jm101349u
	145960813	160791	0	None	-1	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	339	4	2	7	4.0	Nc1nc(NCc2cccs2)nc2sc(-c3ccccc3)nc12	10.1016/j.bmc.2018.05.048
	CHEMBL4125975	160791	0	None	-1	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	339	4	2	7	4.0	Nc1nc(NCc2cccs2)nc2sc(-c3ccccc3)nc12	10.1016/j.bmc.2018.05.048
	54587016	60388	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	520	7	1	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CCN(Cc4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760890	60388	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	520	7	1	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CCN(Cc4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	10761800	187626	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	372	1	2	7	2.5	Cn1c(-c2cccc(C#N)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL49925	187626	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	372	1	2	7	2.5	Cn1c(-c2cccc(C#N)c2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	10688203	101242	0	None	-	1	Rat	6.1	pIC50	=	6.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	335	1	1	5	3.3	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3CCCC3)nc21	10.1021/jm990499b
	CHEMBL299548	101242	0	None	-	1	Rat	6.1	pIC50	=	6.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	335	1	1	5	3.3	Cn1c(-c2cccc(F)c2)nc2c(N)nc(C#CC3CCCC3)nc21	10.1021/jm990499b
	45482082	196536	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	465	7	1	8	4.9	CCCCn1cc2c(nc(NC(=O)Cc3cccc4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL575386	196536	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	465	7	1	8	4.9	CCCCn1cc2c(nc(NC(=O)Cc3cccc4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	136042338	70805	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	449	8	2	9	2.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955914	70805	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	449	8	2	9	2.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	57402118	69423	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	493	7	2	8	5.2	COc1ccc(NC(=O)Nc2nc3cn(CCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	CHEMBL1935749	69423	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	493	7	2	8	5.2	COc1ccc(NC(=O)Nc2nc3cn(CCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	135546649	116123	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	479	9	2	9	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33695	116123	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	479	9	2	9	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	145436760	161581	0	None	-2089	2	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	329	4	2	8	3.6	Nc1nc(NCc2cccs2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4161758	161581	0	None	-2089	2	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	329	4	2	8	3.6	Nc1nc(NCc2cccs2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	10570068	185292	0	None	-	1	Rat	6.1	pIC50	=	6.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	353	1	2	7	2.7	Cn1c(-c2cccs2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL48683	185292	0	None	-	1	Rat	6.1	pIC50	=	6.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	353	1	2	7	2.7	Cn1c(-c2cccs2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	145962310	160809	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	363	5	3	7	3.7	Nc1nc(NCCc2ccc(O)cc2)nc2sc(-c3ccccc3)nc12	10.1016/j.bmc.2018.05.048
	CHEMBL4126116	160809	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	363	5	3	7	3.7	Nc1nc(NCCc2ccc(O)cc2)nc2sc(-c3ccccc3)nc12	10.1016/j.bmc.2018.05.048
	46882997	5549	0	None	-3	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	275	2	1	6	2.9	Cc1ccc(C(=O)c2nc(N)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1077751	5549	0	None	-3	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	275	2	1	6	2.9	Cc1ccc(C(=O)c2nc(N)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	10807613	188896	0	None	-	1	Rat	6.1	pIC50	=	6.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	347	1	2	6	2.7	Cn1c(-c2ccccc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL51394	188896	0	None	-	1	Rat	6.1	pIC50	=	6.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	347	1	2	6	2.7	Cn1c(-c2ccccc2)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	127035806	136836	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	425	7	2	8	3.6	O=C(Cc1ccccc1)Nc1nc(NCc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.ejmech.2015.12.019
	CHEMBL3753079	136836	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activityAntagonist activity at human A2B adenosine receptor expressed in CHO cell membranes assessed as inhibition of NECA stimulated adenylyl cyclase activity	ChEMBL	425	7	2	8	3.6	O=C(Cc1ccccc1)Nc1nc(NCc2ccccc2)nc2nc(-c3ccco3)nn12	10.1016/j.ejmech.2015.12.019
	49797853	10732	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	403	6	2	6	3.0	COc1ccc(N(CCO)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172267	10732	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	403	6	2	6	3.0	COc1ccc(N(CCO)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	10618828	101505	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	365	1	2	6	2.8	Cn1c(-c2ccccc2F)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	CHEMBL301512	101505	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	365	1	2	6	2.8	Cn1c(-c2ccccc2F)nc2c(N)nc(C#CC3(O)CCCCC3)nc21	10.1021/jm990499b
	57393433	69433	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	494	7	2	9	4.6	COc1ccc(NC(=O)Nc2nc3cnn(CCc4ccccc4)c3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	CHEMBL1935758	69433	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	494	7	2	9	4.6	COc1ccc(NC(=O)Nc2nc3cnn(CCc4ccccc4)c3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	45481621	196222	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	491	8	1	8	5.3	CCCCn1cc2c(nc(NC(=O)C(c3ccccc3)c3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL572906	196222	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	491	8	1	8	5.3	CCCCn1cc2c(nc(NC(=O)C(c3ccccc3)c3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	145961937	160897	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	341	4	2	9	2.8	Nc1nc(NCc2cccs2)nc2sc(-c3cnccn3)nc12	10.1016/j.bmc.2018.05.048
	CHEMBL4127472	160897	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assayAntagonist activity at human A2B adenosine receptor assessed as inhibition of NECA-stimulated cAMP level after 30 mins by Alphascreen assay	ChEMBL	341	4	2	9	2.8	Nc1nc(NCc2cccs2)nc2sc(-c3cnccn3)nc12	10.1016/j.bmc.2018.05.048
	57325915	74363	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	362	2	0	6	3.9	O=c1c(-c2ccco2)nnc2n(-c3ccccc3)c3ccc(Cl)cc3n12	10.1021/jm201177b
	CHEMBL2030708	74363	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulationAntagonist activity at human A2B receptor expressed in CHO cells assessed as inhibition of NECA-mediated cAMP accumulation	ChEMBL	362	2	0	6	3.9	O=c1c(-c2ccco2)nnc2n(-c3ccccc3)c3ccc(Cl)cc3n12	10.1021/jm201177b
	49797828	10650	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	431	6	1	7	3.2	COC(=O)CN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171525	10650	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of adenosine-induced cAMP production	ChEMBL	431	6	1	7	3.2	COC(=O)CN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	136042343	70810	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	501	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)c(F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955919	70810	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	501	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)c(F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	54582166	60386	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	7	2	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CC[C@H](NC(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760888	60386	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	7	2	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CC[C@H](NC(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	54581143	60387	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	7	2	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CC[C@@H](NC(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760889	60387	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	548	7	2	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CC[C@@H](NC(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	53248700	60395	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	536	5	2	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)N3CCC(O)(c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760899	60395	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 minsInhibition of human adenosine A2B receptor expressed in CHO cells assessed as decrease in cellular cAMP level after 20 to 25 mins	ChEMBL	536	5	2	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)N3CCC(O)(c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	156821421	185627	0	None	-16	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	443	4	2	9	2.4	Cn1cc(-c2c(-c3ccccc3)nc(N)n3nc([C@H](O)c4ncccc4F)nc23)ccc1=O	10.1021/acsmedchemlett.1c00620
	CHEMBL4873266	185627	0	None	-16	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	443	4	2	9	2.4	Cn1cc(-c2c(-c3ccccc3)nc(N)n3nc([C@H](O)c4ncccc4F)nc23)ccc1=O	10.1021/acsmedchemlett.1c00620
	145436764	161426	0	None	-22	2	Human	8.1	pIC50	=	8.1	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	329	4	2	8	3.6	Nc1nc(NCc2ccsc2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4159215	161426	0	None	-22	2	Human	8.1	pIC50	=	8.1	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	329	4	2	8	3.6	Nc1nc(NCc2ccsc2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	135874424	95391	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	469	8	2	8	2.9	CCCn1c(=O)c2[nH]c(-c3ccn(CC(=O)Nc4ccc(Cl)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL258987	95391	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levelsAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP levels	ChEMBL	469	8	2	8	2.9	CCCn1c(=O)c2[nH]c(-c3ccn(CC(=O)Nc4ccc(Cl)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	136042327	70787	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	512	8	2	9	3.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc6ccccc6cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955893	70787	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	512	8	2	9	3.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc6ccccc6cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	135416058	488	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	442	488	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	CHEMBL2113342	488	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	5606	1606	12	None	-316	7	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	10.1021/jm990499b
	6439091	1606	12	None	-316	7	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	10.1021/jm990499b
	CHEMBL440115	1606	12	None	-316	7	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	10.1021/jm990499b
	145436769	162242	0	None	-2041	2	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	313	4	2	8	3.1	Nc1nc(NCc2ccco2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4172399	162242	0	None	-2041	2	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	313	4	2	8	3.1	Nc1nc(NCc2ccco2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	56950235	69421	0	None	-10	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	403	4	2	8	3.5	COc1ccc(NC(=O)Nc2nc3cn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	CHEMBL1935747	69421	0	None	-10	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	403	4	2	8	3.5	COc1ccc(NC(=O)Nc2nc3cn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1016/j.bmc.2011.11.037
	57400353	69440	0	None	-3	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	432	6	2	9	3.8	CCCn1cc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c2n1	10.1016/j.bmc.2011.11.037
	CHEMBL1935765	69440	0	None	-3	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	432	6	2	9	3.8	CCCn1cc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c2n1	10.1016/j.bmc.2011.11.037
	45481771	196274	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	491	8	1	8	5.4	CCCCn1cc2c(nc(NC(=O)Cc3ccc(-c4ccccc4)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL573360	196274	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	491	8	1	8	5.4	CCCCn1cc2c(nc(NC(=O)Cc3ccc(-c4ccccc4)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	46883207	5887	0	None	2	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	347	5	1	7	3.3	O=C(c1ccncc1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	CHEMBL1080067	5887	0	None	2	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	347	5	1	7	3.3	O=C(c1ccncc1)c1nc(NCc2cccnc2)nc2ccsc12	10.1016/j.bmcl.2009.08.040
	135493279	99904	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL289903	99904	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm201292w
	135493279	99904	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL289903	99904	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	45481759	196656	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	505	8	1	8	5.6	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccc(-c4ccccc4)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL576351	196656	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	505	8	1	8	5.6	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccc(-c4ccccc4)cc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	45481753	197175	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	407	4	1	8	3.1	Cn1cc2c(nc(NC(=O)Cc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL583960	197175	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	407	4	1	8	3.1	Cn1cc2c(nc(NC(=O)Cc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	56951623	70814	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	331	5	2	6	1.0	CCCn1c(=O)c2[nH]c(-c3cc(=O)[nH]n3C)cc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955923	70814	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	331	5	2	6	1.0	CCCn1c(=O)c2[nH]c(-c3cc(=O)[nH]n3C)cc2n(CCC)c1=O	10.1021/jm201292w
	156821390	184644	0	None	-30	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	431	4	2	7	3.0	Nc1nc(-c2ccc(F)cc2)c(-c2ccc(=O)[nH]c2)c2nc(Cc3ccc(F)cn3)nn12	10.1021/acsmedchemlett.1c00620
	CHEMBL4858144	184644	0	None	-30	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	431	4	2	7	3.0	Nc1nc(-c2ccc(F)cc2)c(-c2ccc(=O)[nH]c2)c2nc(Cc3ccc(F)cn3)nn12	10.1021/acsmedchemlett.1c00620
	57398641	69418	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	282	3	1	7	2.3	CCCn1cc2nc(N)n3nc(-c4ccco4)nc3c2c1	10.1016/j.bmc.2011.11.037
	CHEMBL1935744	69418	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	282	3	1	7	2.3	CCCn1cc2nc(N)n3nc(-c4ccco4)nc3c2c1	10.1016/j.bmc.2011.11.037
	156821411	185107	0	None	-1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	373	4	1	8	2.6	Nc1nc(-c2ccccc2)c(-c2ccnnc2)c2nc(CC3CCCO3)nn12	10.1021/acsmedchemlett.1c00620
	CHEMBL4865474	185107	0	None	-1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assayAntagonist activity at human A2bR expressed in CHO-K1 cells assessed as inhibition of cAMP accumulation preincubated for 30 mins followed by adenosine addition and measured for 30 mins by HTRF assay	ChEMBL	373	4	1	8	2.6	Nc1nc(-c2ccccc2)c(-c2ccnnc2)c2nc(CC3CCCO3)nn12	10.1021/acsmedchemlett.1c00620
	45482086	196179	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	421	7	1	9	3.8	CCCCn1cc2c(nc(NC(=O)Cc3ccsc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL572601	196179	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	421	7	1	9	3.8	CCCCn1cc2c(nc(NC(=O)Cc3ccsc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	57395120	69422	0	None	-18	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	431	6	2	8	4.4	CCCn1cc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c2c1	10.1016/j.bmc.2011.11.037
	CHEMBL1935748	69422	0	None	-18	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	431	6	2	8	4.4	CCCn1cc2nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc3c2c1	10.1016/j.bmc.2011.11.037
	145949481	162268	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	343	4	2	8	3.9	Cc1ccc(-c2nc3c(N)nc(NCc4cccs4)nc3s2)o1	10.1016/j.ejmech.2018.06.020
	CHEMBL4172715	162268	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	343	4	2	8	3.9	Cc1ccc(-c2nc3c(N)nc(NCc4cccs4)nc3s2)o1	10.1016/j.ejmech.2018.06.020
	45482094	196152	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	497	7	1	8	4.8	O=C(Cc1cccc(Cl)c1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2009.05.038
	CHEMBL572386	196152	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	497	7	1	8	4.8	O=C(Cc1cccc(Cl)c1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2009.05.038
	57391695	69443	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	337	3	1	8	3.0	Cn1ncc2nc(NC3CCCCC3)n3nc(-c4ccco4)nc3c21	10.1016/j.bmc.2011.11.037
	CHEMBL1935768	69443	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production by competition protein binding assay	ChEMBL	337	3	1	8	3.0	Cn1ncc2nc(NC3CCCCC3)n3nc(-c4ccco4)nc3c21	10.1016/j.bmc.2011.11.037
	46883070	5589	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	367	5	1	8	3.7	Cc1ccc(C(=O)c2nc(NCc3ccncn3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1077902	5589	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	367	5	1	8	3.7	Cc1ccc(C(=O)c2nc(NCc3ccncn3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	135443378	109136	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	623	11	2	9	4.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5ccccc5C(F)(F)F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32229	109136	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	623	11	2	9	4.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5ccccc5C(F)(F)F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	45481756	196521	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	393	5	1	9	3.0	CCn1cc2c(nc(NC(=O)Cc3ccsc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	CHEMBL575198	196521	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	393	5	1	9	3.0	CCn1cc2c(nc(NC(=O)Cc3ccsc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2009.05.038
	46883072	5612	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	6	1	7	4.3	Cc1ccc(C(=O)c2nc(NCCc3ccccn3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	CHEMBL1078085	5612	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assay	ChEMBL	380	6	1	7	4.3	Cc1ccc(C(=O)c2nc(NCCc3ccccn3)nc3ccsc23)s1	10.1016/j.bmcl.2009.08.040
	136042349	70790	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	480	8	2	9	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(F)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955898	70790	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation countingAntagonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced [3H]cAMP production after 150 mins by scintillation counting	ChEMBL	480	8	2	9	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(F)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	135522367	110161	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	493	8	2	10	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc5c(c4)OCO5)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32591	110161	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorInhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor	ChEMBL	493	8	2	10	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc5c(c4)OCO5)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	134133787	142944	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	397	7	2	9	3.6	COc1ccc(CCNc2nc(N)c3nc(-c4ccco4)sc3n2)cc1OC	10.1021/acs.jmedchem.6b01068
	CHEMBL3898647	142944	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	397	7	2	9	3.6	COc1ccc(CCNc2nc(N)c3nc(-c4ccco4)sc3n2)cc1OC	10.1021/acs.jmedchem.6b01068
	145436766	161965	0	None	-102	2	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	324	4	2	8	2.9	Nc1nc(NCc2ccccn2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	CHEMBL4167813	161965	0	None	-102	2	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting methodInverse agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of cAMP accumulation measured after 150 mins in presence of [3H]cAMP by scintillation counting method	ChEMBL	324	4	2	8	2.9	Nc1nc(NCc2ccccn2)nc2sc(-c3ccco3)nc12	10.1016/j.ejmech.2018.06.020
	155516071	169471	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assay	ChEMBL	389	5	3	8	1.4	NCCC(=O)Nc1ccc(-c2cn3c(=O)n(-c4ccccc4)nc3c(N)n2)cc1	10.1021/acs.jmedchem.9b00778
	CHEMBL4442908	169471	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assayAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assay	ChEMBL	389	5	3	8	1.4	NCCC(=O)Nc1ccc(-c2cn3c(=O)n(-c4ccccc4)nc3c(N)n2)cc1	10.1021/acs.jmedchem.9b00778
	10570586	188456	0	None	-	1	Rat	6.0	pIC50	=	6.0	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	361	1	2	6	3.0	Cc1cccc(-c2nc3c(N)nc(C#CC4(O)CCCCC4)nc3n2C)c1	10.1021/jm990499b
	CHEMBL50950	188456	0	None	-	1	Rat	6.0	pIC50	=	6.0	Functional	Inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytesInhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes	ChEMBL	361	1	2	6	3.0	Cc1cccc(-c2nc3c(N)nc(C#CC4(O)CCCCC4)nc3n2C)c1	10.1021/jm990499b
	5606	1606	12	None	-38	7	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	10.1021/jm990499b
	6439091	1606	12	None	-38	7	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	10.1021/jm990499b
	CHEMBL440115	1606	12	None	-38	7	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptorInhibitory activity on NECA-induced cyclic-AMP accumulation in CHO-K1 cells expressing human Adenosine A2B receptor	ChEMBL	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	10.1021/jm990499b
	44587956	174190	0	None	-	0	Rat	9.3	pKd	=	9.3	Functional	Antagonist activity at adenosine A2B receptor in Wistar-Kyoto rat distal colon assessed as inhibition of bethanecol-induced contractionAntagonist activity at adenosine A2B receptor in Wistar-Kyoto rat distal colon assessed as inhibition of bethanecol-induced contraction	ChEMBL	554	9	3	7	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL456125	174190	0	None	-	0	Rat	9.3	pKd	=	9.3	Functional	Antagonist activity at adenosine A2B receptor in Wistar-Kyoto rat distal colon assessed as inhibition of bethanecol-induced contractionAntagonist activity at adenosine A2B receptor in Wistar-Kyoto rat distal colon assessed as inhibition of bethanecol-induced contraction	ChEMBL	554	9	3	7	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	11632785	73174	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	404	5	2	6	2.3	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL201721	73174	0	None	-	0	Human	8.0	pKd	=	8	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	404	5	2	6	2.3	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	136	3228	28	None	-	1	Rat	7.9	pKd	=	7.9	Functional	In vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidineIn vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidine	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00360a008
	223	3228	28	None	-	1	Rat	7.9	pKd	=	7.9	Functional	In vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidineIn vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidine	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00360a008
	643606	3228	28	None	-	1	Rat	7.9	pKd	=	7.9	Functional	In vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidineIn vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidine	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00360a008
	CHEMBL10347	3228	28	None	-	1	Rat	7.9	pKd	=	7.9	Functional	In vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidineIn vitro presynaptic agonist potency at alpha-2 adrenergic receptor in rat or mouse vas deferens relative to clonidine	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00360a008
	44574165	188867	0	None	-	0	Rat	8.7	pKd	=	8.7	Functional	Antagonist activity at adenosine A2B receptor in Wistar-Kyoto rat colon assessed as inhibition of bethanecol-induced contraction after 30 minsAntagonist activity at adenosine A2B receptor in Wistar-Kyoto rat colon assessed as inhibition of bethanecol-induced contraction after 30 mins	ChEMBL	410	4	2	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL513681	188867	0	None	-	0	Rat	8.7	pKd	=	8.7	Functional	Antagonist activity at adenosine A2B receptor in Wistar-Kyoto rat colon assessed as inhibition of bethanecol-induced contraction after 30 minsAntagonist activity at adenosine A2B receptor in Wistar-Kyoto rat colon assessed as inhibition of bethanecol-induced contraction after 30 mins	ChEMBL	410	4	2	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	11684443	132625	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL370378	132625	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11568001	72270	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	422	5	2	6	2.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL199446	72270	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	422	5	2	6	2.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	21874557	3921	46	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm800961g
	5612	3921	46	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm800961g
	CHEMBL447664	3921	46	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm800961g
	DB06625	3921	46	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assayAntagonist activity at human adenosine A2B receptor expressed in CHO-K1 cells by calcium mobilization-based FLIPR assay	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm800961g
	11642035	73182	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	512	6	2	7	3.0	COc1cc(OCC(=O)Nc2ccc(Br)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	CHEMBL201750	73182	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	512	6	2	7	3.0	COc1cc(OCC(=O)Nc2ccc(Br)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	11642035	73182	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	512	6	2	7	3.0	COc1cc(OCC(=O)Nc2ccc(Br)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	CHEMBL201750	73182	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	512	6	2	7	3.0	COc1cc(OCC(=O)Nc2ccc(Br)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	11568001	72270	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	422	5	2	6	2.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL199446	72270	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	422	5	2	6	2.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11632785	73174	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	404	5	2	6	2.3	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL201721	73174	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	404	5	2	6	2.3	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11649145	134668	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	508	8	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(-c5ccccc5)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL372148	134668	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	508	8	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(-c5ccccc5)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11640539	140355	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	429	5	2	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL382135	140355	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	429	5	2	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11640539	140355	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	429	5	2	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL382135	140355	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	429	5	2	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11649145	134668	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	508	8	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(-c5ccccc5)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL372148	134668	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleAntagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle	ChEMBL	508	8	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(-c5ccccc5)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11684443	132625	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL370378	132625	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayAntagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	52950040	18952	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	523	10	2	5	6.1	CC[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289569	18952	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	523	10	2	5	6.1	CC[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	52945195	18970	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	525	10	3	6	4.7	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)N[C@@H](CO)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289676	18970	0	None	-	0	Human	9.4	pKi	=	9.4	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	525	10	3	6	4.7	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)N[C@@H](CO)c1ccccc1	10.1016/j.bmcl.2010.10.030
	450	2911	8	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1016/j.ejmech.2010.04.039
	454	2911	8	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1016/j.ejmech.2010.04.039
	5311041	2911	8	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1016/j.ejmech.2010.04.039
	CHEMBL485862	2911	8	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1016/j.ejmech.2010.04.039
	44574165	188867	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	410	4	2	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(C)c1=O	10.1016/j.ejmech.2017.05.035
	CHEMBL513681	188867	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	410	4	2	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(C)c1=O	10.1016/j.ejmech.2017.05.035
	66894241	157259	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP productionAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	CHEMBL4083317	157259	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP productionAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	66894241	157259	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4083317	157259	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	52946453	19012	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	521	9	2	5	5.6	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NC1(c2ccccc2)CC1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290001	19012	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	521	9	2	5	5.6	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NC1(c2ccccc2)CC1	10.1016/j.bmcl.2010.10.030
	145958145	161516	0	None	-	0	Human	9.0	pKi	=	9.0	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	606	7	1	9	4.5	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(O[C@@H](C)C(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc21	10.1016/j.ejmech.2017.05.035
	CHEMBL4160732	161516	0	None	-	0	Human	9.0	pKi	=	9.0	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	606	7	1	9	4.5	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(O[C@@H](C)C(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc21	10.1016/j.ejmech.2017.05.035
	50925499	19025	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	523	9	2	5	5.9	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290101	19025	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	523	9	2	5	5.9	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	3284	3155	28	None	-	1	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.0c02169
	44185871	3155	28	None	-	1	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.0c02169
	5728	3155	28	None	-	1	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.0c02169
	CHEMBL483688	3155	28	None	-	1	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.0c02169
	145971695	162466	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	496	5	2	6	3.4	C[C@H](Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2017.05.035
	CHEMBL4175851	162466	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	496	5	2	6	3.4	C[C@H](Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)Nc1ccc(Br)cc1	10.1016/j.ejmech.2017.05.035
	3287	2594	38	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	503	10	2	8	3.6	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C	10.1021/jm990421v
	5139184	2594	38	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	503	10	2	8	3.6	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C	10.1021/jm990421v
	CHEMBL17002	2594	38	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	503	10	2	8	3.6	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C	10.1021/jm990421v
	3287	2594	38	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	503	10	2	8	3.6	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C	10.1016/j.ejmech.2010.04.039
	5139184	2594	38	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	503	10	2	8	3.6	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C	10.1016/j.ejmech.2010.04.039
	CHEMBL17002	2594	38	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	503	10	2	8	3.6	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C(=O)C	10.1016/j.ejmech.2010.04.039
	9825550	57273	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	461	9	2	7	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL16677	57273	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	461	9	2	7	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	10839296	57820	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	506	10	2	9	3.3	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL16787	57820	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	506	10	2	9	3.3	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	52943652	19041	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	509	9	2	5	5.7	C[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290210	19041	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	509	9	2	5	5.7	C[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	9846447	58438	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	447	7	2	7	2.9	CCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)[nH]c2n(CC)c1=O	10.1021/jm990421v
	CHEMBL16866	58438	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	447	7	2	7	2.9	CCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)[nH]c2n(CC)c1=O	10.1021/jm990421v
	44236539	156239	0	None	-	1	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	460	7	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4070936	156239	0	None	-	1	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	460	7	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	145952391	162437	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	501	5	1	7	2.7	Cc1ccc(N2CCN(C(=O)[C@H](C)Oc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1	10.1016/j.ejmech.2017.05.035
	CHEMBL4175454	162437	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	501	5	1	7	2.7	Cc1ccc(N2CCN(C(=O)[C@H](C)Oc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1	10.1016/j.ejmech.2017.05.035
	44276476	167520	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	475	9	2	7	3.7	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL432664	167520	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	475	9	2	7	3.7	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	449	2595	44	None	1	4	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm990421v
	453	2595	44	None	1	4	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm990421v
	6603931	2595	44	None	1	4	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm990421v
	CHEMBL273807	2595	44	None	1	4	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm990421v
	449	2595	44	None	1	4	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2010.04.039
	453	2595	44	None	1	4	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2010.04.039
	6603931	2595	44	None	1	4	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2010.04.039
	CHEMBL273807	2595	44	None	1	4	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2010.04.039
	52948915	19084	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	541	9	2	5	6.0	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccc(F)cc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290437	19084	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	541	9	2	5	6.0	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccc(F)cc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	145982075	165919	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	379	6	1	9	2.8	CNc1ncc(C(=O)OCc2cccc(OC)c2)c2nc(-c3ccco3)nn12	10.1016/j.ejmech.2018.08.042
	CHEMBL4278340	165919	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	379	6	1	9	2.8	CNc1ncc(C(=O)OCc2cccc(OC)c2)c2nc(-c3ccco3)nn12	10.1016/j.ejmech.2018.08.042
	1329	1439	78	None	-9	8	Human	6.0	pKi	=	6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.bmc.2009.02.030
	386	1439	78	None	-9	8	Human	6.0	pKi	=	6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.bmc.2009.02.030
	CHEMBL183	1439	78	None	-9	8	Human	6.0	pKi	=	6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.bmc.2009.02.030
	DB12946	1439	78	None	-9	8	Human	6.0	pKi	=	6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.bmc.2009.02.030
	137661874	158743	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 minsAntagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 mins	ChEMBL	405	4	2	7	3.0	COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(O)CC3)nc12	10.1021/acs.jmedchem.6b01584
	CHEMBL4099688	158743	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 minsAntagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 mins	ChEMBL	405	4	2	7	3.0	COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(O)CC3)nc12	10.1021/acs.jmedchem.6b01584
	145980971	165971	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	383	5	1	8	3.4	CNc1ncc(C(=O)OCc2cccc(Cl)c2)c2nc(-c3ccco3)nn12	10.1016/j.ejmech.2018.08.042
	CHEMBL4279340	165971	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	383	5	1	8	3.4	CNc1ncc(C(=O)OCc2cccc(Cl)c2)c2nc(-c3ccco3)nn12	10.1016/j.ejmech.2018.08.042
	145994259	166762	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	424	6	2	7	3.9	CNc1ncc(C(=O)NC(c2ccccc2)c2ccccc2)c2nc(-c3ccco3)nn12	10.1016/j.ejmech.2018.08.042
	CHEMBL4294246	166762	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	424	6	2	7	3.9	CNc1ncc(C(=O)NC(c2ccccc2)c2ccccc2)c2nc(-c3ccco3)nn12	10.1016/j.ejmech.2018.08.042
	118707857	112723	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	315	5	1	8	2.4	CCOC(=O)c1cnc(NC(C)C)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314890	112723	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	315	5	1	8	2.4	CCOC(=O)c1cnc(NC(C)C)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	118707863	112729	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	377	6	1	8	3.5	CCOC(=O)c1cnc(NCc2ccc(C)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314896	112729	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	377	6	1	8	3.5	CCOC(=O)c1cnc(NCc2ccc(C)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	155532918	171226	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based methodAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based method	ChEMBL	480	6	2	10	4.0	Cn1cc2c(nc(NCC3CCC(CNC(=O)OC(C)(C)C)CC3)n3nc(-c4ccco4)nc23)n1	10.1039/C9MD00014C
	CHEMBL4468152	171226	0	None	-	0	Human	5.0	pKi	=	5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based methodAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based method	ChEMBL	480	6	2	10	4.0	Cn1cc2c(nc(NCC3CCC(CNC(=O)OC(C)(C)C)CC3)n3nc(-c4ccco4)nc23)n1	10.1039/C9MD00014C
	52949999	18918	0	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	572	9	1	5	5.1	CN(Cc1ccc(Cl)c(Cl)c1)C(=O)COc1ccc2[nH]c(=O)c(S(C)(=O)=O)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289343	18918	0	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	572	9	1	5	5.1	CN(Cc1ccc(Cl)c(Cl)c1)C(=O)COc1ccc2[nH]c(=O)c(S(C)(=O)=O)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	11687483	162453	0	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	253	3	1	5	2.5	CCCn1c(-c2ccccc2)nc2c(N)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4175631	162453	0	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	253	3	1	5	2.5	CCCn1c(-c2ccccc2)nc2c(N)ncnc21	10.1016/j.ejmech.2018.03.067
	2519	765	83	None	-	2	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2010.04.039
	407	765	83	None	-	2	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2010.04.039
	463	765	83	None	-	2	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2010.04.039
	CHEMBL113	765	83	None	-	2	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2010.04.039
	DB00201	765	83	None	-	2	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2010.04.039
	44572292	170836	1	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	255	1	1	5	1.8	CC(C)n1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL446264	170836	1	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	255	1	1	5	1.8	CC(C)n1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	123683	3060	58	None	-1258	5	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1016/j.ejmech.2018.08.042
	422	3060	58	None	-1258	5	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1016/j.ejmech.2018.08.042
	CHEMBL119709	3060	58	None	-1258	5	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1016/j.ejmech.2018.08.042
	DB05511	3060	58	None	-1258	5	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1016/j.ejmech.2018.08.042
	71455624	82526	0	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	309	3	1	8	2.2	Cn1cc2c(nc(NC3CCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181159	82526	0	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	309	3	1	8	2.2	Cn1cc2c(nc(NC3CCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	22002449	112709	0	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	273	3	1	8	1.1	CCOC(=O)c1cnc(N)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314876	112709	0	None	-	0	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	273	3	1	8	1.1	CCOC(=O)c1cnc(N)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	823558	15060	9	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	271	2	2	6	0.8	COc1ccc2c(C)nc(NC3=NCC(=O)N3)nc2c1	10.1016/j.ejmech.2010.04.039
	CHEMBL1210817	15060	9	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	271	2	2	6	0.8	COc1ccc2c(C)nc(NC3=NCC(=O)N3)nc2c1	10.1016/j.ejmech.2010.04.039
	10475082	74	15	None	-	0	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	383	4	4	9	0.8	OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	5591	74	15	None	-	0	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	383	4	4	9	0.8	OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	CHEMBL251997	74	15	None	-	0	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	383	4	4	9	0.8	OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	155562044	175187	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based methodAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based method	ChEMBL	426	7	2	10	3.0	Cn1cc2c(nc(NCCCCNC(=O)OC(C)(C)C)n3nc(-c4ccco4)nc23)n1	10.1039/C9MD00014C
	CHEMBL4583657	175187	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based methodAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based method	ChEMBL	426	7	2	10	3.0	Cn1cc2c(nc(NCCCCNC(=O)OC(C)(C)C)n3nc(-c4ccco4)nc23)n1	10.1039/C9MD00014C
	11681113	161696	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	309	4	1	6	2.7	CCn1c(-c2ccccc2)nc2c(NC3CCOC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4163630	161696	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	309	4	1	6	2.7	CCn1c(-c2ccccc2)nc2c(NC3CCOC3)ncnc21	10.1016/j.ejmech.2018.03.067
	118707845	112710	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	377	4	3	7	2.4	CNC(=O)c1cnc(NC(=O)Nc2ccccc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314877	112710	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	377	4	3	7	2.4	CNC(=O)c1cnc(NC(=O)Nc2ccccc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	44572295	188445	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	269	2	1	5	2.1	CCC(C)n1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL509367	188445	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	269	2	1	5	2.1	CCC(C)n1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	44447535	94551	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	458	5	4	11	0.2	CNC(=S)OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	CHEMBL254896	94551	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	458	5	4	11	0.2	CNC(=S)OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	71457390	82496	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	359	4	1	8	3.4	C[C@@H](Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12)c1ccccc1	10.1021/jm300899q
	CHEMBL2180932	82496	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	359	4	1	8	3.4	C[C@@H](Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12)c1ccccc1	10.1021/jm300899q
	49863226	15034	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	311	3	1	9	0.6	Nc1nc(-n2cncn2)c2nnn(Cc3ccccc3F)c2n1	10.1016/j.ejmech.2010.04.039
	CHEMBL1210734	15034	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	311	3	1	9	0.6	Nc1nc(-n2cncn2)c2nnn(Cc3ccccc3F)c2n1	10.1016/j.ejmech.2010.04.039
	22002364	112704	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	423	8	1	10	3.2	CCOC(=O)c1cnc(NCc2ccc(OC)c(OC)c2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314871	112704	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	423	8	1	10	3.2	CCOC(=O)c1cnc(NCc2ccc(OC)c(OC)c2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	11659363	162156	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	295	3	1	6	2.2	Cn1c(-c2ccccc2)nc2c(NC3CCOC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4170873	162156	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	295	3	1	6	2.2	Cn1c(-c2ccccc2)nc2c(NC3CCOC3)ncnc21	10.1016/j.ejmech.2018.03.067
	11568203	95784	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	432	5	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL260975	95784	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	432	5	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1016/j.ejmech.2010.04.039
	66892244	158374	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	491	8	1	9	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(OC)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4095686	158374	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	491	8	1	9	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(OC)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	71412032	137731	4	None	-	0	Human	6.9	pKi	=	6.9	Functional	Agonist activity at recombinant human adenosine A2B receptor assessed as cAMP accumulation preincubated for 45 mins followed by forskolin addition measured after 15 mins by protein kinase A-based assay in presence of [3H]cyclic AMP, rolipram, adenosine deaminaseAgonist activity at recombinant human adenosine A2B receptor assessed as cAMP accumulation preincubated for 45 mins followed by forskolin addition measured after 15 mins by protein kinase A-based assay in presence of [3H]cyclic AMP, rolipram, adenosine deaminase	ChEMBL	294	4	4	9	-1.4	CCNC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00828
	CHEMBL3770601	137731	4	None	-	0	Human	6.9	pKi	=	6.9	Functional	Agonist activity at recombinant human adenosine A2B receptor assessed as cAMP accumulation preincubated for 45 mins followed by forskolin addition measured after 15 mins by protein kinase A-based assay in presence of [3H]cyclic AMP, rolipram, adenosine deaminaseAgonist activity at recombinant human adenosine A2B receptor assessed as cAMP accumulation preincubated for 45 mins followed by forskolin addition measured after 15 mins by protein kinase A-based assay in presence of [3H]cyclic AMP, rolipram, adenosine deaminase	ChEMBL	294	4	4	9	-1.4	CCNC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.5b00828
	541903	57626	1	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	382	8	2	7	1.4	C=CCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CC=C)c1=O	10.1021/jm990421v
	CHEMBL16724	57626	1	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	382	8	2	7	1.4	C=CCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CC=C)c1=O	10.1021/jm990421v
	11529450	162215	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	293	4	1	5	3.5	CCn1c(-c2ccccc2)nc2c(NC3CCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4171919	162215	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	293	4	1	5	3.5	CCn1c(-c2ccccc2)nc2c(NC3CCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	18440405	136083	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	374	6	2	6	3.2	CCCn1c(Br)nc2c(N)nc(NCCc3ccccc3)nc21	10.1039/C5MD00034C
	CHEMBL3739795	136083	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	374	6	2	6	3.2	CCCn1c(Br)nc2c(N)nc(NCCc3ccccc3)nc21	10.1039/C5MD00034C
	52943652	19041	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	509	9	2	5	5.7	C[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290210	19041	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	509	9	2	5	5.7	C[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	9871761	59156	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	533	11	4	9	1.2	CCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(CC(=O)NCCN)cc4)cc3)[nH]c2n(CC)c1=O	10.1021/jm990421v
	CHEMBL17141	59156	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	533	11	4	9	1.2	CCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(CC(=O)NCCN)cc4)cc3)[nH]c2n(CC)c1=O	10.1021/jm990421v
	11610869	79831	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	393	5	3	8	-1.0	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)NCC(=O)O)cc3)[nH]c2n(C)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL213878	79831	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	393	5	3	8	-1.0	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)NCC(=O)O)cc3)[nH]c2n(C)c1=O	10.1016/j.ejmech.2010.04.039
	9935943	58701	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	505	10	3	8	3.1	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(=O)O)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL16931	58701	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	505	10	3	8	3.1	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(=O)O)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	541615	97063	1	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	385	8	2	7	1.2	CCCn1c(=O)c2nc(-c3ccc(OCC(N)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL27043	97063	1	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	385	8	2	7	1.2	CCCn1c(=O)c2nc(-c3ccc(OCC(N)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	10839228	59537	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	504	8	2	8	2.1	CCCn1c(=O)c2nc(-c3ccc(/C=C/C(=O)NN4C(=O)C(C)=C(C)C4=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL17294	59537	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	504	8	2	8	2.1	CCCn1c(=O)c2nc(-c3ccc(/C=C/C(=O)NN4C(=O)C(C)=C(C)C4=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	414707	201936	7	None	-	0	Human	4.8	pKi	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	177	1	1	5	1.0	CC(C)n1cnc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL67199	201936	7	None	-	0	Human	4.8	pKi	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	177	1	1	5	1.0	CC(C)n1cnc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	118707866	112732	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	397	6	1	8	3.8	CCOC(=O)c1cnc(NCc2ccc(Cl)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314899	112732	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	397	6	1	8	3.8	CCOC(=O)c1cnc(NCc2ccc(Cl)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	317946	15033	3	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	272	1	1	7	0.3	Cn1c(=O)c2c(nc(-c3ccccc3)n2O)n(C)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL1210733	15033	3	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	272	1	1	7	0.3	Cn1c(=O)c2c(nc(-c3ccccc3)n2O)n(C)c1=O	10.1016/j.ejmech.2010.04.039
	52950206	18904	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	476	8	2	5	3.7	CS(=O)(=O)c1c(CCc2ccccc2)c2cc(OCC(=O)Nc3ccccc3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	CHEMBL1289228	18904	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	476	8	2	5	3.7	CS(=O)(=O)c1c(CCc2ccccc2)c2cc(OCC(=O)Nc3ccccc3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	52946113	19060	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	522	8	3	4	6.2	CC(C)(NC(=O)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290323	19060	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	522	8	3	4	6.2	CC(C)(NC(=O)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL5080823	212925	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL		None	None	None		CCCn1c(=O)c2nc(C34CCC(C(=O)NCCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O	10.1021/acs.jmedchem.0c02169
	247436	179657	23	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	177	2	1	5	0.8	CCCn1cnc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	247436	179657	23	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	177	2	1	5	0.8	CCCn1cnc2c(N)ncnc21	10.1039/C5MD00034C
	CHEMBL475023	179657	23	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	177	2	1	5	0.8	CCCn1cnc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL475023	179657	23	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	177	2	1	5	0.8	CCCn1cnc2c(N)ncnc21	10.1039/C5MD00034C
	452612	173921	15	None	-	0	Human	4.8	pKi	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	189	1	1	5	1.1	Nc1ncnc2c1ncn2C1CCC1	10.1016/j.bmc.2009.02.030
	CHEMBL455493	173921	15	None	-	0	Human	4.8	pKi	=	4.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	189	1	1	5	1.1	Nc1ncnc2c1ncn2C1CCC1	10.1016/j.bmc.2009.02.030
	52947452	19101	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	558	9	2	5	4.7	CS(=O)(=O)c1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	CHEMBL1290543	19101	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	558	9	2	5	4.7	CS(=O)(=O)c1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	1892	202338	74	None	-	0	Human	4.8	pKi	=	4.8	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	224	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCO)n(C)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL699	202338	74	None	-	0	Human	4.8	pKi	=	4.8	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	224	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCO)n(C)c1=O	10.1016/j.ejmech.2010.04.039
	127038356	136174	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	360	5	2	6	3.2	CCCn1c(Br)nc2c(N)nc(NCc3ccccc3)nc21	10.1039/C5MD00034C
	CHEMBL3740631	136174	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	360	5	2	6	3.2	CCCn1c(Br)nc2c(N)nc(NCc3ccccc3)nc21	10.1039/C5MD00034C
	71462774	82525	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	295	3	1	8	1.8	Cn1cc2c(nc(NC3CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181158	82525	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	295	3	1	8	1.8	Cn1cc2c(nc(NC3CC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	10624626	162575	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	482	8	2	7	3.1	O=C(O)COc1ccc(-c2nc3c(=O)n(Cc4ccccc4)c(=O)n(Cc4ccccc4)c3[nH]2)cc1	10.1021/jm990421v
	CHEMBL417812	162575	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	482	8	2	7	3.1	O=C(O)COc1ccc(-c2nc3c(=O)n(Cc4ccccc4)c(=O)n(Cc4ccccc4)c3[nH]2)cc1	10.1021/jm990421v
	127042993	136095	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	333	6	1	6	4.1	CCCn1c(-c2ccco2)nc2c(NCc3ccccc3)ncnc21	10.1039/C5MD00034C
	CHEMBL3739903	136095	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	333	6	1	6	4.1	CCCn1c(-c2ccco2)nc2c(NCc3ccccc3)ncnc21	10.1039/C5MD00034C
	127042996	136218	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	373	7	1	5	4.0	CCCn1c(Br)nc2c(NCCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	CHEMBL3741012	136218	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	373	7	1	5	4.0	CCCn1c(Br)nc2c(NCCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	2840092	199354	41	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	245	3	3	4	1.6	CCOc1cccc2c(C)nc(NC(=N)N)nc12	10.1016/j.ejmech.2010.04.039
	CHEMBL602578	199354	41	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	245	3	3	4	1.6	CCOc1cccc2c(C)nc(NC(=N)N)nc12	10.1016/j.ejmech.2010.04.039
	135438480	162356	0	None	-	1	Human	4.8	pKi	=	4.8	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	309	3	2	6	3.1	Cn1c(-c2ccc(O)cc2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4174108	162356	0	None	-	1	Human	4.8	pKi	=	4.8	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	309	3	2	6	3.1	Cn1c(-c2ccc(O)cc2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	135610070	71942	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	377	8	2	9	0.8	CCCn1c(=O)c2nc(-c3cc(OCC(=O)O)no3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	CHEMBL198326	71942	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	377	8	2	9	0.8	CCCn1c(=O)c2nc(-c3cc(OCC(=O)O)no3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	52947301	18775	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	517	9	2	4	5.8	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3cccnc3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1287832	18775	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	517	9	2	4	5.8	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3cccnc3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	127042997	136345	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	361	8	1	6	4.5	CCCn1c(-c2ccco2)nc2c(NCCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	CHEMBL3742158	136345	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	361	8	1	6	4.5	CCCn1c(-c2ccco2)nc2c(NCCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	118707851	112716	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	392	5	2	8	3.2	CCOC(=O)c1cnc(NC(=O)Nc2ccccc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314883	112716	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	392	5	2	8	3.2	CCOC(=O)c1cnc(NC(=O)Nc2ccccc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	44572293	177845	1	None	-	0	Human	4.7	pKi	=	4.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	191	2	1	5	1.4	CCC(C)n1cnc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL466044	177845	1	None	-	0	Human	4.7	pKi	=	4.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	191	2	1	5	1.4	CCC(C)n1cnc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	66892382	158594	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	559	9	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(OC(F)(F)F)cc5)C4=O)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4098127	158594	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	559	9	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(OC(F)(F)F)cc5)C4=O)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	52946159	19082	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	493	9	2	4	5.7	O=C(CCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290435	19082	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	493	9	2	4	5.7	O=C(CCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	52949755	19027	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	468	6	2	5	3.2	Cc1c(S(C)(=O)=O)c(=O)[nH]c2ccc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)cc12	10.1016/j.bmcl.2010.10.030
	CHEMBL1290103	19027	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	468	6	2	5	3.2	Cc1c(S(C)(=O)=O)c(=O)[nH]c2ccc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)cc12	10.1016/j.bmcl.2010.10.030
	118707865	112731	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	381	6	1	8	3.3	CCOC(=O)c1cnc(NCc2ccc(F)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314898	112731	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	381	6	1	8	3.3	CCOC(=O)c1cnc(NCc2ccc(F)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	9957239	59089	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	490	7	2	6	4.8	O=C(O)/C=C/c1ccc(-c2nc3c(=O)n(CC4CCCCC4)c(=O)n(CC4CCCCC4)c3[nH]2)cc1	10.1021/jm990421v
	CHEMBL17103	59089	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	490	7	2	6	4.8	O=C(O)/C=C/c1ccc(-c2nc3c(=O)n(CC4CCCCC4)c(=O)n(CC4CCCCC4)c3[nH]2)cc1	10.1021/jm990421v
	136086750	8618	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NSCA-induced cAMP accumulation pre-incubated for 15 mins by enzyme immunoassayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NSCA-induced cAMP accumulation pre-incubated for 15 mins by enzyme immunoassay	ChEMBL	349	3	4	6	1.9	N=C1c2c(C(N)=O)nc(-c3ccccc3O)n2CN1c1ccc(O)cc1	10.1016/j.bmc.2010.03.048
	CHEMBL1095872	8618	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NSCA-induced cAMP accumulation pre-incubated for 15 mins by enzyme immunoassayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NSCA-induced cAMP accumulation pre-incubated for 15 mins by enzyme immunoassay	ChEMBL	349	3	4	6	1.9	N=C1c2c(C(N)=O)nc(-c3ccccc3O)n2CN1c1ccc(O)cc1	10.1016/j.bmc.2010.03.048
	9912816	97969	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	475	10	2	7	3.1	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL275605	97969	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	475	10	2	7	3.1	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	11801496	98279	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	587	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL278039	98279	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	587	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	11801496	98279	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	587	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL278039	98279	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	587	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.ejmech.2010.04.039
	10792296	98200	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	529	9	2	7	4.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(F)(F)F)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL277386	98200	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	529	9	2	7	4.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(F)(F)F)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	10767043	58699	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	479	9	2	7	3.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL16929	58699	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	479	9	2	7	3.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	10840167	58851	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	539	9	2	7	4.2	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL17003	58851	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	539	9	2	7	4.2	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	10720065	97932	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	495	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL275427	97932	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	495	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	9870718	59656	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	503	10	2	8	3.6	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4C(C)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL17341	59656	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	503	10	2	8	3.6	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4C(C)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	72197880	90353	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	347	4	1	5	4.7	O=C(Nc1nc(-c2ccccc2)c(-c2ccncc2)s1)c1ccco1	10.1016/j.ejmech.2013.03.020
	CHEMBL2391834	90353	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	347	4	1	5	4.7	O=C(Nc1nc(-c2ccccc2)c(-c2ccncc2)s1)c1ccco1	10.1016/j.ejmech.2013.03.020
	52945195	18970	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	525	10	3	6	4.7	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)N[C@@H](CO)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289676	18970	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	525	10	3	6	4.7	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)N[C@@H](CO)c1ccccc1	10.1016/j.bmcl.2010.10.030
	11849871	188232	2	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	255	2	1	5	1.6	CCCn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	11849871	188232	2	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	255	2	1	5	1.6	CCCn1c(Br)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	11849871	188232	2	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	255	2	1	5	1.6	CCCn1c(Br)nc2c(N)ncnc21	10.1039/C5MD00034C
	CHEMBL506450	188232	2	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	255	2	1	5	1.6	CCCn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL506450	188232	2	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	255	2	1	5	1.6	CCCn1c(Br)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL506450	188232	2	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	255	2	1	5	1.6	CCCn1c(Br)nc2c(N)ncnc21	10.1039/C5MD00034C
	137636304	155648	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 minsAntagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 mins	ChEMBL	419	4	2	7	3.4	COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(C)(O)CC3)nc12	10.1021/acs.jmedchem.6b01584
	CHEMBL4064207	155648	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 minsAntagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 mins	ChEMBL	419	4	2	7	3.4	COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(C)(O)CC3)nc12	10.1021/acs.jmedchem.6b01584
	137645935	157022	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 minsAntagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 mins	ChEMBL	446	6	1	8	3.5	COc1cnc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3ccc(F)cc3)nc12	10.1021/acs.jmedchem.6b01584
	CHEMBL4080594	157022	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 minsAntagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 mins	ChEMBL	446	6	1	8	3.5	COc1cnc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3ccc(F)cc3)nc12	10.1021/acs.jmedchem.6b01584
	22002375	112708	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	258	2	2	7	0.3	CNC(=O)c1cnc(N)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314875	112708	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	258	2	2	7	0.3	CNC(=O)c1cnc(N)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	18440417	136125	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	362	7	2	7	3.7	CCCn1c(-c2ccco2)nc2c(N)nc(NCCc3ccccc3)nc21	10.1039/C5MD00034C
	CHEMBL3740141	136125	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	362	7	2	7	3.7	CCCn1c(-c2ccco2)nc2c(N)nc(NCCc3ccccc3)nc21	10.1039/C5MD00034C
	118707867	112733	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	431	6	1	8	4.2	CCOC(=O)c1cnc(NCc2ccc(C(F)(F)F)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314900	112733	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	431	6	1	8	4.2	CCOC(=O)c1cnc(NCc2ccc(C(F)(F)F)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	52944930	19083	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	495	9	2	5	5.1	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290436	19083	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	495	9	2	5	5.1	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	459	2570	31	None	-	1	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm300323t
	477	2570	31	None	-	1	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm300323t
	5310960	2570	31	None	-	1	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm300323t
	CHEMBL302765	2570	31	None	-	1	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm300323t
	20592013	94155	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	371	4	4	10	-0.7	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	CHEMBL252198	94155	0	None	-	0	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	371	4	4	10	-0.7	OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	21874755	176308	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	336	4	2	8	1.8	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(C(=O)O)c3)c2n1	10.1016/j.ejmech.2010.04.039
	CHEMBL461656	176308	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	336	4	2	8	1.8	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(C(=O)O)c3)c2n1	10.1016/j.ejmech.2010.04.039
	71450241	82513	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	269	2	1	8	1.3	CNc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181147	82513	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	269	2	1	8	1.3	CNc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	71453892	82514	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	283	3	1	8	1.7	CCNc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181148	82514	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	283	3	1	8	1.7	CCNc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	24827444	95884	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	365	5	1	8	1.6	CCCn1c(=O)c2[nH]c(-c3cnn(-c4cccnc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL261526	95884	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	365	5	1	8	1.6	CCCn1c(=O)c2[nH]c(-c3cnn(-c4cccnc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2010.04.039
	9870396	138495	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	494	7	1	7	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)ccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL378598	138495	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	494	7	1	7	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)ccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1016/j.ejmech.2010.04.039
	21916394	160254	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	458	6	1	7	3.2	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21	10.1016/j.ejmech.2010.04.039
	CHEMBL411452	160254	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	458	6	1	7	3.2	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21	10.1016/j.ejmech.2010.04.039
	CHEMBL5074992	212569	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL		None	None	None		CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCOCCOCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O	10.1021/acs.jmedchem.0c02169
	9929470	109971	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm500752h
	CHEMBL324735	109971	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm500752h
	118707859	112725	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	313	5	1	8	2.1	CCOC(=O)c1cnc(NC2CC2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314892	112725	0	None	-	0	Human	5.7	pKi	=	5.7	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	313	5	1	8	2.1	CCOC(=O)c1cnc(NC2CC2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	158795	3699	27	None	-	2	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	337	4	4	10	-1.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1COCC1	10.1016/j.bmc.2007.09.035
	5592	3699	27	None	-	2	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	337	4	4	10	-1.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1COCC1	10.1016/j.bmc.2007.09.035
	CHEMBL392149	3699	27	None	-	2	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	337	4	4	10	-1.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1COCC1	10.1016/j.bmc.2007.09.035
	DB04954	3699	27	None	-	2	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	337	4	4	10	-1.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1COCC1	10.1016/j.bmc.2007.09.035
	99619	201769	22	None	-	0	Human	4.6	pKi	=	4.6	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	223	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCN)n(C)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL66011	201769	22	None	-	0	Human	4.6	pKi	=	4.6	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	223	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCN)n(C)c1=O	10.1016/j.ejmech.2010.04.039
	101874280	112720	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	287	4	1	8	1.6	CCOC(=O)c1cnc(NC)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314887	112720	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	287	4	1	8	1.6	CCOC(=O)c1cnc(NC)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	22002319	112706	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	408	7	2	9	2.4	CNC(=O)c1cnc(NCc2ccc(OC)c(OC)c2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314873	112706	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	408	7	2	9	2.4	CNC(=O)c1cnc(NCc2ccc(OC)c(OC)c2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	1330	162655	37	None	-	3	Human	6.6	pKi	=	6.6	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	CHEMBL418333	162655	37	None	-	3	Human	6.6	pKi	=	6.6	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	CHEMBL435575	162655	37	None	-	3	Human	6.6	pKi	=	6.6	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	9887859	113000	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL118923	113000	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	CHEMBL332091	113000	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP productionAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP production	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300323t
	76331702	103210	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	243	3	1	6	2.1	CCCn1c(-c2ccco2)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL3087706	103210	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	243	3	1	6	2.1	CCCn1c(-c2ccco2)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	76335304	103212	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	333	4	1	6	2.8	Cn1c(-c2ccco2)nc2c(NC(=O)Cc3ccccc3)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL3087708	103212	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	333	4	1	6	2.8	Cn1c(-c2ccco2)nc2c(NC(=O)Cc3ccccc3)ncnc21	10.1016/j.ejmech.2013.10.006
	118707862	112728	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	363	6	1	8	3.2	CCOC(=O)c1cnc(NCc2ccccc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314895	112728	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	363	6	1	8	3.2	CCOC(=O)c1cnc(NCc2ccccc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	76331702	103210	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	243	3	1	6	2.1	CCCn1c(-c2ccco2)nc2c(N)ncnc21	10.1039/C5MD00034C
	CHEMBL3087706	103210	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	243	3	1	6	2.1	CCCn1c(-c2ccco2)nc2c(N)ncnc21	10.1039/C5MD00034C
	11587927	162111	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	327	3	1	5	4.0	Cn1c(-c2cccc(Cl)c2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4170180	162111	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	327	3	1	5	4.0	Cn1c(-c2cccc(Cl)c2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL5089483	213425	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL		None	None	None		CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O	10.1021/acs.jmedchem.0c02169
	9936058	59231	1	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	508	9	2	9	1.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NN4C(=O)C(C)=C(C)C4=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL17173	59231	1	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	508	9	2	9	1.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NN4C(=O)C(C)=C(C)C4=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	377	2707	47	None	-	10	Rat	5.6	pKi	=	5.6	Functional	Activity against Adenosine A2B receptor as cAMP production in VA-13 cellsActivity against Adenosine A2B receptor as cAMP production in VA-13 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm9802822
	425	2707	47	None	-	10	Rat	5.6	pKi	=	5.6	Functional	Activity against Adenosine A2B receptor as cAMP production in VA-13 cellsActivity against Adenosine A2B receptor as cAMP production in VA-13 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm9802822
	448222	2707	47	None	-	10	Rat	5.6	pKi	=	5.6	Functional	Activity against Adenosine A2B receptor as cAMP production in VA-13 cellsActivity against Adenosine A2B receptor as cAMP production in VA-13 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm9802822
	CHEMBL464859	2707	47	None	-	10	Rat	5.6	pKi	=	5.6	Functional	Activity against Adenosine A2B receptor as cAMP production in VA-13 cellsActivity against Adenosine A2B receptor as cAMP production in VA-13 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm9802822
	71462773	82518	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	311	4	1	8	2.5	CC[C@H](C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181151	82518	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	311	4	1	8	2.5	CC[C@H](C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	71457391	82499	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	379	4	1	8	3.5	Cn1cc2c(nc(NCc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2180935	82499	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	379	4	1	8	3.5	Cn1cc2c(nc(NCc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	71457407	82527	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	323	3	1	8	2.6	Cn1cc2c(nc(NC3CCCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181160	82527	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	323	3	1	8	2.6	Cn1cc2c(nc(NC3CCCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	52942475	19043	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	489	9	2	5	5.7	CC(C)CCc1c(-c2nccs2)c(=O)[nH]c2ccc(OCC(=O)NC(C)(C)c3ccccc3)cc12	10.1016/j.bmcl.2010.10.030
	CHEMBL1290212	19043	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	489	9	2	5	5.7	CC(C)CCc1c(-c2nccs2)c(=O)[nH]c2ccc(OCC(=O)NC(C)(C)c3ccccc3)cc12	10.1016/j.bmcl.2010.10.030
	42636897	172061	20	None	-	0	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	379	4	3	8	1.3	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(NC4CC5CCC4C5)ncnc32)[C@@H]1O	10.1021/jm801456g
	CHEMBL449575	172061	20	None	-	0	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	379	4	3	8	1.3	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(NC4CC5CCC4C5)ncnc32)[C@@H]1O	10.1021/jm801456g
	76331703	103216	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	453	7	1	7	4.7	Cc1ccc(COc2ccc(CC(=O)Nc3ncnc4c3nc(-c3ccco3)n4C)cc2)cc1	10.1016/j.ejmech.2013.10.006
	CHEMBL3087712	103216	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	453	7	1	7	4.7	Cc1ccc(COc2ccc(CC(=O)Nc3ncnc4c3nc(-c3ccco3)n4C)cc2)cc1	10.1016/j.ejmech.2013.10.006
	71462755	82504	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	359	5	1	8	2.9	Cn1cc2c(nc(NCCc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2180940	82504	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	359	5	1	8	2.9	Cn1cc2c(nc(NCCc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	44572469	178861	10	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	257	2	2	6	0.2	Nc1ncnc2c1nc(Br)n2CCO	10.1016/j.ejmech.2010.04.039
	CHEMBL474058	178861	10	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	257	2	2	6	0.2	Nc1ncnc2c1nc(Br)n2CCO	10.1016/j.ejmech.2010.04.039
	44572469	178861	10	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	257	2	2	6	0.2	Nc1ncnc2c1nc(Br)n2CCO	10.1016/j.bmc.2009.02.030
	44572469	178861	10	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	257	2	2	6	0.2	Nc1ncnc2c1nc(Br)n2CCO	10.1016/j.ejmech.2013.10.006
	CHEMBL474058	178861	10	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	257	2	2	6	0.2	Nc1ncnc2c1nc(Br)n2CCO	10.1016/j.bmc.2009.02.030
	CHEMBL474058	178861	10	None	-	0	Human	5.6	pKi	=	5.6	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	257	2	2	6	0.2	Nc1ncnc2c1nc(Br)n2CCO	10.1016/j.ejmech.2013.10.006
	24882472	154104	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	456	5	4	10	1.4	CNC(=S)OC[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	CHEMBL399514	154104	0	None	-	0	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	456	5	4	10	1.4	CNC(=S)OC[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	71459268	82507	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	398	5	2	8	3.4	Cn1cc2c(nc(NCCc3c[nH]c4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181141	82507	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	398	5	2	8	3.4	Cn1cc2c(nc(NCCc3c[nH]c4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	9806649	59216	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	518	10	3	8	2.8	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(=O)NC)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL17167	59216	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	518	10	3	8	2.8	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(=O)NC)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	11605883	79527	5	None	-	1	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL212625	79527	5	None	-	1	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1016/j.ejmech.2010.04.039
	9892149	59298	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	499	9	2	7	4.2	CCCn1c(=O)c2nc(-c3ccc(/C=C/C(=O)Nc4ccccc4C(C)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL17202	59298	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	499	9	2	7	4.2	CCCn1c(=O)c2nc(-c3ccc(/C=C/C(=O)Nc4ccccc4C(C)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	541759	169457	1	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	477	9	3	8	3.1	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(O)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL444281	169457	1	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	477	9	3	8	3.1	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(O)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	9936467	57771	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	519	10	2	9	3.2	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(=O)OC)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL16741	57771	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	519	10	2	9	3.2	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(=O)OC)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	155544096	172724	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based methodAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based method	ChEMBL	440	8	2	10	3.4	Cn1cc2c(nc(NCCCCCNC(=O)OC(C)(C)C)n3nc(-c4ccco4)nc23)n1	10.1039/C9MD00014C
	CHEMBL4526138	172724	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based methodAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase by [alpha-32P]ATP based method	ChEMBL	440	8	2	10	3.4	Cn1cc2c(nc(NCCCCCNC(=O)OC(C)(C)C)n3nc(-c4ccco4)nc23)n1	10.1039/C9MD00014C
	11053743	162316	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	239	2	1	5	2.1	CCn1c(-c2ccccc2)nc2c(N)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4173347	162316	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	239	2	1	5	2.1	CCn1c(-c2ccccc2)nc2c(N)ncnc21	10.1016/j.ejmech.2018.03.067
	118707855	112721	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	301	5	1	8	2.0	CCNc1ncc(C(=O)OCC)c2nc(-c3ccco3)nn12	10.1021/jm500752h
	CHEMBL3314888	112721	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	301	5	1	8	2.0	CCNc1ncc(C(=O)OCC)c2nc(-c3ccco3)nn12	10.1021/jm500752h
	44447534	94527	0	None	-	0	Human	4.5	pKi	=	4.5	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	442	5	4	11	0.0	CNC(=O)OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	CHEMBL254693	94527	0	None	-	0	Human	4.5	pKi	=	4.5	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	442	5	4	11	0.0	CNC(=O)OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	136199393	19026	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	521	9	2	5	5.7	Cc1cc(-c2c(CCc3ccccc3)c3cc(OCC(=O)NC(C)(C)c4ccccc4)ccc3[nH]c2=O)on1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290102	19026	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	521	9	2	5	5.7	Cc1cc(-c2c(CCc3ccccc3)c3cc(OCC(=O)NC(C)(C)c4ccccc4)ccc3[nH]c2=O)on1	10.1016/j.bmcl.2010.10.030
	52947452	19101	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	558	9	2	5	4.7	CS(=O)(=O)c1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	CHEMBL1290543	19101	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	558	9	2	5	4.7	CS(=O)(=O)c1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	71461028	82500	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	363	4	1	8	3.0	Cn1cc2c(nc(NCc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2180936	82500	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	363	4	1	8	3.0	Cn1cc2c(nc(NCc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	127038355	136172	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	359	6	1	5	3.7	CCCn1c(Br)nc2c(NCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	CHEMBL3740619	136172	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	359	6	1	5	3.7	CCCn1c(Br)nc2c(NCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	52941244	19040	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	509	9	2	5	5.7	C[C@@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290209	19040	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	509	9	2	5	5.7	C[C@@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	14426726	181045	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	353	4	3	8	1.0	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(NC4CCCC4)ncnc32)[C@@H]1O	10.1021/jm801456g
	CHEMBL477444	181045	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	353	4	3	8	1.0	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(NC4CCCC4)ncnc32)[C@@H]1O	10.1021/jm801456g
	9807634	59555	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	551	11	2	7	4.7	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NC(c4ccccc4)c4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL17299	59555	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	551	11	2	7	4.7	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NC(c4ccccc4)c4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	52950027	18936	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	478	9	2	4	5.3	O=C(COc1ccc2[nH]c(=O)c(-c3ccco3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289461	18936	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	478	9	2	4	5.3	O=C(COc1ccc2[nH]c(=O)c(-c3ccco3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	71453874	82494	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	345	4	1	8	2.9	Cn1cc2c(nc(NCc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2180930	82494	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	345	4	1	8	2.9	Cn1cc2c(nc(NCc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	2519	765	83	None	-	2	Human	4.5	pKi	=	4.5	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2021.113907
	407	765	83	None	-	2	Human	4.5	pKi	=	4.5	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2021.113907
	463	765	83	None	-	2	Human	4.5	pKi	=	4.5	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2021.113907
	CHEMBL113	765	83	None	-	2	Human	4.5	pKi	=	4.5	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2021.113907
	DB00201	765	83	None	-	2	Human	4.5	pKi	=	4.5	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2021.113907
	52950028	18937	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	461	7	2	5	4.7	CC(C)(C)NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289462	18937	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	461	7	2	5	4.7	CC(C)(C)NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	11623934	161489	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	321	5	1	5	4.3	CCCn1c(-c2ccccc2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4160264	161489	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	321	5	1	5	4.3	CCCn1c(-c2ccccc2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	52941597	18886	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	357	5	1	4	2.7	COc1ccc2[nH]c(=O)c(S(C)(=O)=O)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289109	18886	0	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	357	5	1	4	2.7	COc1ccc2[nH]c(=O)c(S(C)(=O)=O)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL5092788	213604	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL		None	None	None		C#CCCCCNC(=O)C12CCC(c3nc4c(=O)n(CCCC)c(=O)n(CCCNC(=O)c5ccc(S(=O)(=O)F)cc5)c4[nH]3)(CC1)CC2	10.1021/acs.jmedchem.0c02169
	76335303	103211	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	259	4	2	7	1.1	Nc1ncnc2c1nc(-c1ccco1)n2CCCO	10.1016/j.ejmech.2013.10.006
	CHEMBL3087707	103211	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	259	4	2	7	1.1	Nc1ncnc2c1nc(-c1ccco1)n2CCCO	10.1016/j.ejmech.2013.10.006
	52945098	19142	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	504	9	1	6	3.4	Cn1c(=O)c(S(C)(=O)=O)c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccccc3)ccc21	10.1016/j.bmcl.2010.10.030
	CHEMBL1290782	19142	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	504	9	1	6	3.4	Cn1c(=O)c(S(C)(=O)=O)c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccccc3)ccc21	10.1016/j.bmcl.2010.10.030
	145987819	166590	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	363	5	1	8	3.3	CNc1ncc(C(=O)OC(C)c2ccccc2)c2nc(-c3ccco3)nn12	10.1016/j.ejmech.2018.08.042
	CHEMBL4290842	166590	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	363	5	1	8	3.3	CNc1ncc(C(=O)OC(C)c2ccccc2)c2nc(-c3ccco3)nn12	10.1016/j.ejmech.2018.08.042
	11492857	161789	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	279	3	1	5	3.0	Cn1c(-c2ccccc2)nc2c(NC3CCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4165013	161789	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	279	3	1	5	3.0	Cn1c(-c2ccccc2)nc2c(NC3CCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	11229946	103219	1	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	229	2	1	6	1.7	CCn1c(-c2ccco2)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL3087715	103219	1	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	229	2	1	6	1.7	CCn1c(-c2ccco2)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	71457405	82517	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	311	4	1	8	2.5	CCC(C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181150	82517	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	311	4	1	8	2.5	CCC(C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	71455619	82505	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	419	7	1	10	2.9	COc1ccc(CCNc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1OC	10.1021/jm300899q
	CHEMBL2181139	82505	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	419	7	1	10	2.9	COc1ccc(CCNc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1OC	10.1021/jm300899q
	10085373	10314	6	None	-	1	Human	6.4	pKi	=	6.4	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	286	2	1	6	0.6	COc1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1016/j.ejmech.2010.04.039
	CHEMBL11635	10314	6	None	-	1	Human	6.4	pKi	=	6.4	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	286	2	1	6	0.6	COc1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1016/j.ejmech.2010.04.039
	71455603	82497	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	359	4	1	8	3.2	Cc1ccc(CNc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm300899q
	CHEMBL2180933	82497	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	359	4	1	8	3.2	Cc1ccc(CNc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm300899q
	71455622	82520	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	325	6	1	8	2.9	CCCCCNc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181153	82520	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	325	6	1	8	2.9	CCCCCNc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	57429649	158384	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP productionAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production	ChEMBL	572	8	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	CHEMBL4095843	158384	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP productionAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production	ChEMBL	572	8	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	66892867	155766	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	479	7	1	8	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4065629	155766	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	479	7	1	8	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	57429649	158384	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	572	8	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4095843	158384	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	572	8	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	11690712	77424	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	439	7	3	6	2.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCc4ccccc4)cc3)nc2c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL209230	77424	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	439	7	3	6	2.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCc4ccccc4)cc3)nc2c1=O	10.1016/j.ejmech.2010.04.039
	52946453	19012	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	521	9	2	5	5.6	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NC1(c2ccccc2)CC1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290001	19012	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	521	9	2	5	5.6	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NC1(c2ccccc2)CC1	10.1016/j.bmcl.2010.10.030
	44404010	72217	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	480	9	2	8	2.9	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)nc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	CHEMBL199249	72217	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	480	9	2	8	2.9	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)nc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	135528632	72203	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	329	5	2	7	1.5	CCCn1c(=O)c2nc(-c3ccc(O)nc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	CHEMBL199196	72203	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	329	5	2	7	1.5	CCCn1c(=O)c2nc(-c3ccc(O)nc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	9870719	57101	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	503	10	2	8	3.6	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4cccc(C(C)=O)c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL16534	57101	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	503	10	2	8	3.6	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4cccc(C(C)=O)c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	126079	4025	20	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm990421v
	451	4025	20	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm990421v
	CHEMBL27041	4025	20	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm990421v
	52950027	18936	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	478	9	2	4	5.3	O=C(COc1ccc2[nH]c(=O)c(-c3ccco3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289461	18936	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	478	9	2	4	5.3	O=C(COc1ccc2[nH]c(=O)c(-c3ccco3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	52950000	18919	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	505	8	2	4	5.2	N#Cc1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	CHEMBL1289344	18919	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	505	8	2	4	5.2	N#Cc1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	52948915	19084	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	541	9	2	5	6.0	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccc(F)cc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290437	19084	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	541	9	2	5	6.0	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccc(F)cc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	44572409	189089	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	267	1	1	5	1.9	Nc1ncnc2c1nc(Br)n2C1CCC1	10.1016/j.bmc.2009.02.030
	CHEMBL515419	189089	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	267	1	1	5	1.9	Nc1ncnc2c1nc(Br)n2C1CCC1	10.1016/j.bmc.2009.02.030
	123807	856	47	None	-12022	7	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	374	856	47	None	-12022	7	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	379	856	47	None	-12022	7	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	CHEMBL284969	856	47	None	-12022	7	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	176407	4069	76	None	-13	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated [3H]cAMP production by scintillation countingAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated [3H]cAMP production by scintillation counting	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm900718w
	405	4069	76	None	-13	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated [3H]cAMP production by scintillation countingAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated [3H]cAMP production by scintillation counting	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm900718w
	CHEMBL113142	4069	76	None	-13	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated [3H]cAMP production by scintillation countingAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated [3H]cAMP production by scintillation counting	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm900718w
	DB08770	4069	76	None	-13	2	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated [3H]cAMP production by scintillation countingAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated [3H]cAMP production by scintillation counting	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm900718w
	44572355	178994	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	269	2	1	5	1.8	CC(C)Cn1c(Br)nc2c(N)ncnc21	10.1016/j.ejmech.2010.04.039
	CHEMBL474207	178994	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	269	2	1	5	1.8	CC(C)Cn1c(Br)nc2c(N)ncnc21	10.1016/j.ejmech.2010.04.039
	44572355	178994	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	269	2	1	5	1.8	CC(C)Cn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL474207	178994	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	269	2	1	5	1.8	CC(C)Cn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	380	1256	49	None	-	5	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	657378	1256	49	None	-	5	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	CHEMBL68738	1256	49	None	-	5	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10.1016/j.bmc.2007.09.035
	9915751	58802	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	557	14	1	11	1.7	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(CC(=O)OCC)CC(=O)OCC)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL16984	58802	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	557	14	1	11	1.7	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(CC(=O)OCC)CC(=O)OCC)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	44447542	154240	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	351	4	4	10	-1.0	C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N[C@@H]3CCOC3)ncnc21	10.1016/j.bmc.2007.09.035
	CHEMBL400190	154240	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	351	4	4	10	-1.0	C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N[C@@H]3CCOC3)ncnc21	10.1016/j.bmc.2007.09.035
	44447548	154335	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	385	4	4	10	-0.3	C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N[C@@H]3CCOC3)nc(Cl)nc21	10.1016/j.bmc.2007.09.035
	CHEMBL400782	154335	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	385	4	4	10	-0.3	C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N[C@@H]3CCOC3)nc(Cl)nc21	10.1016/j.bmc.2007.09.035
	44572408	188263	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	253	2	1	5	1.4	C=CCn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL506888	188263	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	253	2	1	5	1.4	C=CCn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	127042409	136238	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	348	6	2	7	3.7	CCCn1c(-c2ccco2)nc2c(N)nc(NCc3ccccc3)nc21	10.1039/C5MD00034C
	CHEMBL3741217	136238	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	348	6	2	7	3.7	CCCn1c(-c2ccco2)nc2c(N)nc(NCc3ccccc3)nc21	10.1039/C5MD00034C
	118707860	112726	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	341	5	1	8	2.9	CCOC(=O)c1cnc(NC2CCCC2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314893	112726	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	341	5	1	8	2.9	CCOC(=O)c1cnc(NC2CCCC2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	9912946	58678	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	478	7	2	6	3.7	O=C(O)/C=C/c1ccc(-c2nc3c(=O)n(Cc4ccccc4)c(=O)n(Cc4ccccc4)c3[nH]2)cc1	10.1021/jm990421v
	CHEMBL16908	58678	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	478	7	2	6	3.7	O=C(O)/C=C/c1ccc(-c2nc3c(=O)n(Cc4ccccc4)c(=O)n(Cc4ccccc4)c3[nH]2)cc1	10.1021/jm990421v
	76335305	103221	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	245	3	2	7	0.7	Nc1ncnc2c1nc(-c1ccco1)n2CCO	10.1016/j.ejmech.2013.10.006
	CHEMBL3087717	103221	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	245	3	2	7	0.7	Nc1ncnc2c1nc(-c1ccco1)n2CCO	10.1016/j.ejmech.2013.10.006
	10387088	59129	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	414	10	2	7	2.6	CCCCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CCCC)c1=O	10.1021/jm990421v
	CHEMBL17123	59129	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	414	10	2	7	2.6	CCCCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3)[nH]c2n(CCCC)c1=O	10.1021/jm990421v
	71455621	82519	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	311	4	1	8	2.5	CC[C@@H](C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181152	82519	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	311	4	1	8	2.5	CC[C@@H](C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	118707864	112730	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	393	7	1	9	3.2	CCOC(=O)c1cnc(NCc2ccc(OC)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314897	112730	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	393	7	1	9	3.2	CCOC(=O)c1cnc(NCc2ccc(OC)cc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	44582613	181046	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	387	4	3	8	1.7	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@@H]1O	10.1021/jm801456g
	CHEMBL477445	181046	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	387	4	3	8	1.7	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@@H]1O	10.1021/jm801456g
	118707847	112712	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	376	5	2	7	1.9	CNC(=O)c1cnc(NC(=O)Cc2ccccc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314879	112712	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	376	5	2	7	1.9	CNC(=O)c1cnc(NC(=O)Cc2ccccc2)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	21958762	155227	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	288	4	2	6	0.7	CCCn1c(=O)c2[nH]c(-c3cn[nH]c3)nc2n(CC)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL405901	155227	0	None	-	0	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	288	4	2	6	0.7	CCCn1c(=O)c2[nH]c(-c3cn[nH]c3)nc2n(CC)c1=O	10.1016/j.ejmech.2010.04.039
	10021483	186290	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	361	4	4	9	0.0	OC[C@H]1O[C@@H](n2cnc3c(NC4CC5CCC4C5)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm801456g
	CHEMBL489640	186290	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAgonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	361	4	4	9	0.0	OC[C@H]1O[C@@H](n2cnc3c(NC4CC5CCC4C5)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm801456g
	50925499	19025	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	523	9	2	5	5.9	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290101	19025	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	523	9	2	5	5.9	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	10648228	97970	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	475	9	1	7	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(C)c4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL275606	97970	0	None	-	0	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	475	9	1	7	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(C)c4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	135484064	2568	3	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm049418o
	390	2568	3	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm049418o
	CHEMBL260331	2568	3	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm049418o
	135484064	2568	3	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2010.04.039
	390	2568	3	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2010.04.039
	CHEMBL260331	2568	3	None	-	1	Human	8.3	pKi	=	8.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2010.04.039
	52942359	18985	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	517	9	2	4	5.8	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3ccccn3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289778	18985	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	517	9	2	4	5.8	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3ccccn3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	76313600	103215	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	439	7	1	7	4.4	Cn1c(-c2ccco2)nc2c(NC(=O)Cc3ccc(OCc4ccccc4)cc3)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL3087711	103215	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	439	7	1	7	4.4	Cn1c(-c2ccco2)nc2c(NC(=O)Cc3ccc(OCc4ccccc4)cc3)ncnc21	10.1016/j.ejmech.2013.10.006
	44572471	180015	2	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	271	3	2	6	0.6	Nc1ncnc2c1nc(Br)n2CCCO	10.1016/j.bmc.2009.02.030
	44572471	180015	2	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	271	3	2	6	0.6	Nc1ncnc2c1nc(Br)n2CCCO	10.1016/j.ejmech.2013.10.006
	CHEMBL475455	180015	2	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	271	3	2	6	0.6	Nc1ncnc2c1nc(Br)n2CCCO	10.1016/j.bmc.2009.02.030
	CHEMBL475455	180015	2	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	271	3	2	6	0.6	Nc1ncnc2c1nc(Br)n2CCCO	10.1016/j.ejmech.2013.10.006
	52942501	19061	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	515	8	2	5	5.6	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCC(F)(F)F)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290324	19061	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	515	8	2	5	5.6	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCC(F)(F)F)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	71455620	82506	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	387	6	1	8	3.7	CC(CCc1ccccc1)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181140	82506	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	387	6	1	8	3.7	CC(CCc1ccccc1)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	71452056	82495	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human A2B receptor expressed in CHO cell membrane assessed as reduction in NECA-stimulated adenylyl cyclase activity in presence of [alpha32P]ATPAntagonist activity at human A2B receptor expressed in CHO cell membrane assessed as reduction in NECA-stimulated adenylyl cyclase activity in presence of [alpha32P]ATP	ChEMBL	359	4	1	8	3.4	C[C@H](Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12)c1ccccc1	10.1039/d0md00380h
	CHEMBL2180931	82495	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human A2B receptor expressed in CHO cell membrane assessed as reduction in NECA-stimulated adenylyl cyclase activity in presence of [alpha32P]ATPAntagonist activity at human A2B receptor expressed in CHO cell membrane assessed as reduction in NECA-stimulated adenylyl cyclase activity in presence of [alpha32P]ATP	ChEMBL	359	4	1	8	3.4	C[C@H](Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12)c1ccccc1	10.1039/d0md00380h
	71452056	82495	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	359	4	1	8	3.4	C[C@H](Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12)c1ccccc1	10.1021/jm300899q
	CHEMBL2180931	82495	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	359	4	1	8	3.4	C[C@H](Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12)c1ccccc1	10.1021/jm300899q
	11602451	161691	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	335	5	1	5	4.6	CCCn1c(-c2ccccc2)nc2c(NC3CCCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4163601	161691	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	335	5	1	5	4.6	CCCn1c(-c2ccccc2)nc2c(NC3CCCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	118707844	112591	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	348	5	2	7	1.9	Nc1ncc(C(=O)NCCc2ccccc2)c2nc(-c3ccco3)nn12	10.1021/jm500752h
	CHEMBL3313941	112591	0	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	348	5	2	7	1.9	Nc1ncc(C(=O)NCCc2ccccc2)c2nc(-c3ccco3)nn12	10.1021/jm500752h
	136414902	159155	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	560	9	1	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4104450	159155	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	560	9	1	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	1329	1439	78	None	-9	8	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.ejmech.2010.04.039
	386	1439	78	None	-9	8	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.ejmech.2010.04.039
	CHEMBL183	1439	78	None	-9	8	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.ejmech.2010.04.039
	DB12946	1439	78	None	-9	8	Human	7.3	pKi	=	7.3	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.ejmech.2010.04.039
	52933926	155629	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubated for 15 mins followed by NECA addition measured after 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubated for 15 mins followed by NECA addition measured after 15 mins by HTRF assay	ChEMBL	353	5	1	6	3.7	CCCn1c(Oc2cccnc2C)nc2nc(C3CCCC3)[nH]c2c1=O	10.1016/j.bmc.2017.02.029
	CHEMBL4063997	155629	0	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubated for 15 mins followed by NECA addition measured after 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubated for 15 mins followed by NECA addition measured after 15 mins by HTRF assay	ChEMBL	353	5	1	6	3.7	CCCn1c(Oc2cccnc2C)nc2nc(C3CCCC3)[nH]c2c1=O	10.1016/j.bmc.2017.02.029
	11608719	188146	18	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	269	3	1	5	2.0	CCCCn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL505089	188146	18	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	269	3	1	5	2.0	CCCCn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	11623708	161941	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	307	4	1	5	3.9	CCn1c(-c2ccccc2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4167491	161941	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	307	4	1	5	3.9	CCn1c(-c2ccccc2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	11774068	94115	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	404	4	2	6	2.4	CCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL251876	94115	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	404	4	2	6	2.4	CCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2010.04.039
	10158974	154956	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	418	5	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.05.035
	CHEMBL404168	154956	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysisAntagonist activity at Adenosine receptor subtype 2B in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis	ChEMBL	418	5	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.05.035
	CHEMBL5076192	212638	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL		None	None	None		CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCCCCCCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O	10.1021/acs.jmedchem.0c02169
	443	742	7	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10.1021/jm990421v
	6439089	742	7	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10.1021/jm990421v
	CHEMBL16997	742	7	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10.1021/jm990421v
	52941244	19040	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	509	9	2	5	5.7	C[C@@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290209	19040	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	509	9	2	5	5.7	C[C@@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	118732285	117848	0	None	-	0	Human	4.2	pKi	=	4.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	311	5	1	7	1.8	CCOC(=O)c1nc(N)nc2nn(CCc3ccccc3)cc12	10.1016/j.ejmech.2015.01.046
	CHEMBL3410301	117848	0	None	-	0	Human	4.2	pKi	=	4.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity	ChEMBL	311	5	1	7	1.8	CCOC(=O)c1nc(N)nc2nn(CCc3ccccc3)cc12	10.1016/j.ejmech.2015.01.046
	11681092	162149	0	None	-	1	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	307	3	1	5	3.7	Cc1cccc(-c2nc3c(NC4CCCC4)ncnc3n2C)c1	10.1016/j.ejmech.2018.03.067
	CHEMBL4170850	162149	0	None	-	1	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	307	3	1	5	3.7	Cc1cccc(-c2nc3c(NC4CCCC4)ncnc3n2C)c1	10.1016/j.ejmech.2018.03.067
	145991283	166282	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	364	6	2	9	3.0	CCOC(=O)c1cnc(NNc2ccccc2)n2nc(-c3ccco3)nc12	10.1016/j.ejmech.2018.08.042
	CHEMBL4285374	166282	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assayAntagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity by [alpha-32P]ATP based assay	ChEMBL	364	6	2	9	3.0	CCOC(=O)c1cnc(NNc2ccccc2)n2nc(-c3ccco3)nc12	10.1016/j.ejmech.2018.08.042
	52944930	19083	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	495	9	2	5	5.1	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290436	19083	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	495	9	2	5	5.1	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	76324475	103217	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	334	3	2	6	3.3	Cn1c(-c2ccco2)nc2c(NC(=O)Nc3ccccc3)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL3087713	103217	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	334	3	2	6	3.3	Cn1c(-c2ccco2)nc2c(NC(=O)Nc3ccccc3)ncnc21	10.1016/j.ejmech.2013.10.006
	18440528	136096	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	388	7	2	6	3.6	CCCn1c(Br)nc2c(N)nc(NCCCc3ccccc3)nc21	10.1039/C5MD00034C
	CHEMBL3739922	136096	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	388	7	2	6	3.6	CCCn1c(Br)nc2c(N)nc(NCCCc3ccccc3)nc21	10.1039/C5MD00034C
	71453894	82528	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	337	3	1	8	3.0	Cn1cc2c(nc(NC3CCCCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181161	82528	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	337	3	1	8	3.0	Cn1cc2c(nc(NC3CCCCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	52948671	19102	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	520	11	1	5	4.8	COCCCNC(=O)COc1ccc2c(c1)c(CCc1ccccc1)c(-c1ccc(F)cc1F)c(=O)n2C	10.1016/j.bmcl.2010.10.030
	CHEMBL1290544	19102	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	520	11	1	5	4.8	COCCCNC(=O)COc1ccc2c(c1)c(CCc1ccccc1)c(-c1ccc(F)cc1F)c(=O)n2C	10.1016/j.bmcl.2010.10.030
	44572473	180171	2	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	271	2	2	6	0.6	CC(O)Cn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL475617	180171	2	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	271	2	2	6	0.6	CC(O)Cn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	132941757	158341	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 minsAntagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 mins	ChEMBL	460	7	1	7	4.4	CCN(CC)C1CCC(C)(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)CC1	10.1021/acs.jmedchem.6b01584
	CHEMBL4095355	158341	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 minsAntagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pretreated for 15 mins followed by agonist addition for 15 mins and subsequent forskolin stimulation measured after 30 mins	ChEMBL	460	7	1	7	4.4	CCN(CC)C1CCC(C)(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)CC1	10.1021/acs.jmedchem.6b01584
	137631671	155780	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubated for 15 mins followed by NECA addition measured after 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubated for 15 mins followed by NECA addition measured after 15 mins by HTRF assay	ChEMBL	352	5	1	5	3.9	CCCn1c(-c2cccc(OC)c2)nc2nc(C3CCCC3)[nH]c2c1=O	10.1016/j.bmc.2017.02.029
	CHEMBL4065762	155780	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubated for 15 mins followed by NECA addition measured after 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubated for 15 mins followed by NECA addition measured after 15 mins by HTRF assay	ChEMBL	352	5	1	5	3.9	CCCn1c(-c2cccc(OC)c2)nc2nc(C3CCCC3)[nH]c2c1=O	10.1016/j.bmc.2017.02.029
	71450242	82529	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	351	3	1	8	3.4	Cn1cc2c(nc(NC3CCCCCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181162	82529	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	351	3	1	8	3.4	Cn1cc2c(nc(NC3CCCCCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	52950000	18919	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	505	8	2	4	5.2	N#Cc1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	CHEMBL1289344	18919	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	505	8	2	4	5.2	N#Cc1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	52949755	19027	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	468	6	2	5	3.2	Cc1c(S(C)(=O)=O)c(=O)[nH]c2ccc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)cc12	10.1016/j.bmcl.2010.10.030
	CHEMBL1290103	19027	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	468	6	2	5	3.2	Cc1c(S(C)(=O)=O)c(=O)[nH]c2ccc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)cc12	10.1016/j.bmcl.2010.10.030
	52948949	19059	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	494	8	3	4	5.4	O=C(NCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290322	19059	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	494	8	3	4	5.4	O=C(NCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	10226014	94141	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	452	6	2	9	2.4	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL252048	94141	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	452	6	2	9	2.4	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c1=O	10.1016/j.ejmech.2010.04.039
	52950040	18952	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	523	10	2	5	6.1	CC[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289569	18952	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	523	10	2	5	6.1	CC[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	404	4023	30	None	1318	2	Human	8.1	pKi	=	8.1	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/jm990421v
	432	4023	30	None	1318	2	Human	8.1	pKi	=	8.1	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/jm990421v
	5697	4023	30	None	1318	2	Human	8.1	pKi	=	8.1	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/jm990421v
	CHEMBL273094	4023	30	None	1318	2	Human	8.1	pKi	=	8.1	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/jm990421v
	9827467	97922	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	504	10	3	8	2.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(N)=O)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL275360	97922	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	504	10	3	8	2.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C(N)=O)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	135921140	11223	0	None	-	0	Mouse	5.2	pKi	=	5.2	Functional	Inhibition against A2B-Adenosine Receptor in mouse NIH 3T3 fibroblast cell membranes (functional antagonist activity)Inhibition against A2B-Adenosine Receptor in mouse NIH 3T3 fibroblast cell membranes (functional antagonist activity)	ChEMBL	267	1	1	4	1.7	Cn1c(-c2ccccc2)nc2c1C1=NCCN1C(=O)N2	10.1021/jm011093d
	CHEMBL117962	11223	0	None	-	0	Mouse	5.2	pKi	=	5.2	Functional	Inhibition against A2B-Adenosine Receptor in mouse NIH 3T3 fibroblast cell membranes (functional antagonist activity)Inhibition against A2B-Adenosine Receptor in mouse NIH 3T3 fibroblast cell membranes (functional antagonist activity)	ChEMBL	267	1	1	4	1.7	Cn1c(-c2ccccc2)nc2c1C1=NCCN1C(=O)N2	10.1021/jm011093d
	52946114	19062	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	525	9	2	6	5.7	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(COc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290325	19062	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAAntagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISA	ChEMBL	525	9	2	6	5.7	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(COc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	69029783	155774	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	570	9	1	8	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4065717	155774	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	570	9	1	8	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	2773172	188181	12	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	287	3	3	7	-0.5	Nc1ncnc2c1nc(Br)n2CC(O)CO	10.1016/j.bmc.2009.02.030
	CHEMBL505633	188181	12	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	287	3	3	7	-0.5	Nc1ncnc2c1nc(Br)n2CC(O)CO	10.1016/j.bmc.2009.02.030
	118707879	112745	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	329	6	1	8	2.6	CCOC(=O)c1cnc(NCC(C)C)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	CHEMBL3314913	112745	0	None	-	0	Human	5.2	pKi	=	5.2	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	329	6	1	8	2.6	CCOC(=O)c1cnc(NCC(C)C)n2nc(-c3ccco3)nc12	10.1021/jm500752h
	822296	188514	15	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	227	0	1	5	0.7	Cn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	822296	188514	15	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	227	0	1	5	0.7	Cn1c(Br)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL510288	188514	15	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	227	0	1	5	0.7	Cn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL510288	188514	15	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	227	0	1	5	0.7	Cn1c(Br)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	71457403	82508	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	299	4	2	9	0.7	Cn1cc2c(nc(NCCO)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181142	82508	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	299	4	2	9	0.7	Cn1cc2c(nc(NCCO)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	127040410	136234	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	345	5	1	5	3.6	CCCn1c(Br)nc2c(NCc3ccccc3)ncnc21	10.1039/C5MD00034C
	CHEMBL3741167	136234	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	345	5	1	5	3.6	CCCn1c(Br)nc2c(NCc3ccccc3)ncnc21	10.1039/C5MD00034C
	71455601	82482	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	375	6	1	9	2.8	Cn1cc2c(nc(NCCOc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2180918	82482	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	375	6	1	9	2.8	Cn1cc2c(nc(NCCOc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	71452072	82521	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	353	7	1	8	3.7	CCCCCC(C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181154	82521	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	353	7	1	8	3.7	CCCCCC(C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	11565780	161718	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	307	5	1	5	3.9	CCCn1c(-c2ccccc2)nc2c(NC3CCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4164048	161718	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	307	5	1	5	3.9	CCCn1c(-c2ccccc2)nc2c(NC3CCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	308531	165157	9	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	225	1	1	5	1.6	Cn1c(-c2ccccc2)nc2c(N)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL424597	165157	9	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	225	1	1	5	1.6	Cn1c(-c2ccccc2)nc2c(N)ncnc21	10.1016/j.ejmech.2018.03.067
	76324476	103220	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	215	1	1	6	1.2	Cn1c(-c2ccco2)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL3087716	103220	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	215	1	1	6	1.2	Cn1c(-c2ccco2)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL5073669	212520	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL		None	None	None		CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O	10.1021/acs.jmedchem.0c02169
	76309882	103214	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	409	5	1	6	4.4	Cn1c(-c2ccco2)nc2c(NC(=O)C(c3ccccc3)c3ccccc3)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL3087710	103214	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	409	5	1	6	4.4	Cn1c(-c2ccco2)nc2c(NC(=O)C(c3ccccc3)c3ccccc3)ncnc21	10.1016/j.ejmech.2013.10.006
	44236568	155917	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	486	6	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4067401	155917	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	486	6	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	69031481	156523	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP productionAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production	ChEMBL	529	7	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2021.113907
	CHEMBL4074253	156523	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP productionAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production	ChEMBL	529	7	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2021.113907
	57429602	156685	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP productionAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	CHEMBL4076435	156685	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP productionAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	69031481	156523	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	529	7	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4074253	156523	0	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assayAntagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 mins followed by NECA stimulation for 15 mins by HTRF assay	ChEMBL	529	7	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	57429602	156685	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4076435	156685	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of NECA-induced increase in cAMP accumulation incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	72197883	90356	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	407	5	2	9	3.2	CN(C)c1nc(N)nc(-c2sc(NC(=O)c3ccco3)nc2-c2ccccc2)n1	10.1016/j.ejmech.2013.03.020
	CHEMBL2391837	90356	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	407	5	2	9	3.2	CN(C)c1nc(N)nc(-c2sc(NC(=O)c3ccco3)nc2-c2ccccc2)n1	10.1016/j.ejmech.2013.03.020
	52946114	19062	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	525	9	2	6	5.7	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(COc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290325	19062	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	525	9	2	6	5.7	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(COc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	439176	98156	63	None	-	2	Human	5.1	pKi	=	5.1	Functional	Binding affinity towards human adenosine A2B receptor in VA13 fibroblasts as inhibition of adenylate cyclase at 10 uM; Less than 10% inhibitionBinding affinity towards human adenosine A2B receptor in VA13 fibroblasts as inhibition of adenylate cyclase at 10 uM; Less than 10% inhibition	ChEMBL	297	3	3	9	-0.6	CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm031092g
	CHEMBL277041	98156	63	None	-	2	Human	5.1	pKi	=	5.1	Functional	Binding affinity towards human adenosine A2B receptor in VA13 fibroblasts as inhibition of adenylate cyclase at 10 uM; Less than 10% inhibitionBinding affinity towards human adenosine A2B receptor in VA13 fibroblasts as inhibition of adenylate cyclase at 10 uM; Less than 10% inhibition	ChEMBL	297	3	3	9	-0.6	CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm031092g
	127040064	136215	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	376	8	2	7	4.1	CCCn1c(-c2ccco2)nc2c(N)nc(NCCCc3ccccc3)nc21	10.1039/C5MD00034C
	CHEMBL3740992	136215	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	376	8	2	7	4.1	CCCn1c(-c2ccco2)nc2c(N)nc(NCCCc3ccccc3)nc21	10.1039/C5MD00034C
	44447519	94432	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	440	5	4	10	1.2	CNC(=O)OC[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	CHEMBL254064	94432	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	440	5	4	10	1.2	CNC(=O)OC[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O	10.1016/j.bmc.2007.09.035
	25188209	178172	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	311	3	1	8	1.6	Nc1nc(-c2ncco2)c2nnn(Cc3ccccc3F)c2n1	10.1016/j.ejmech.2010.04.039
	CHEMBL468701	178172	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	311	3	1	8	1.6	Nc1nc(-c2ncco2)c2nnn(Cc3ccccc3F)c2n1	10.1016/j.ejmech.2010.04.039
	5248753	178166	4	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	241	1	1	5	1.2	CCn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	5248753	178166	4	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	241	1	1	5	1.2	CCn1c(Br)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	CHEMBL468633	178166	4	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	241	1	1	5	1.2	CCn1c(Br)nc2c(N)ncnc21	10.1016/j.bmc.2009.02.030
	CHEMBL468633	178166	4	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	241	1	1	5	1.2	CCn1c(Br)nc2c(N)ncnc21	10.1016/j.ejmech.2013.10.006
	72197703	90352	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	347	4	1	5	4.7	O=C(Nc1nc(-c2ccccc2)c(-c2ccccn2)s1)c1ccco1	10.1016/j.ejmech.2013.03.020
	CHEMBL2391833	90352	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	347	4	1	5	4.7	O=C(Nc1nc(-c2ccccc2)c(-c2ccccn2)s1)c1ccco1	10.1016/j.ejmech.2013.03.020
	71457389	82480	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	285	3	1	9	1.2	CONc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2180916	82480	0	None	-	0	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	285	3	1	9	1.2	CONc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	11587409	162434	0	None	-	1	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	293	3	1	5	3.4	Cn1c(-c2ccccc2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4175366	162434	0	None	-	1	Human	5.1	pKi	=	5.1	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	293	3	1	5	3.4	Cn1c(-c2ccccc2)nc2c(NC3CCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	12016633	172091	1	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	281	1	1	5	2.3	Nc1ncnc2c1nc(Br)n2C1CCCC1	10.1016/j.bmc.2009.02.030
	CHEMBL449924	172091	1	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	281	1	1	5	2.3	Nc1ncnc2c1nc(Br)n2C1CCCC1	10.1016/j.bmc.2009.02.030
	9946338	154239	38	None	-	0	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	349	4	4	9	0.2	C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NC3CCCC3)ncnc21	10.1016/j.bmc.2007.09.035
	CHEMBL400189	154239	38	None	-	0	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activityAgonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	ChEMBL	349	4	4	9	0.2	C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NC3CCCC3)ncnc21	10.1016/j.bmc.2007.09.035
	52941201	19013	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	517	9	2	4	5.8	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3ccncc3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290002	19013	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hrAntagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins before NECA challenge measured after 1 hr	ChEMBL	517	9	2	4	5.8	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3ccncc3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	10267860	176239	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	317	3	1	8	2.0	N#Cc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1016/j.ejmech.2010.04.039
	CHEMBL461007	176239	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	317	3	1	8	2.0	N#Cc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1016/j.ejmech.2010.04.039
	11198201	110175	6	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	327	5	2	6	2.0	CCCn1c(=O)c2nc(-c3ccc(N)cc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	CHEMBL32598	110175	6	None	-	0	Human	8.1	pKi	=	8.1	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	327	5	2	6	2.0	CCCn1c(=O)c2nc(-c3ccc(N)cc3)[nH]c2n(CCC)c1=O	10.1021/jm049418o
	14484978	97130	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	483	9	1	10	1.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)ON4C(=O)CCC4=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL27081	97130	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	483	9	1	10	1.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)ON4C(=O)CCC4=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	9850900	97886	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	565	12	1	7	5.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	CHEMBL275149	97886	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXAntagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPX	ChEMBL	565	12	1	7	5.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm990421v
	9850900	97886	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	565	12	1	7	5.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.ejmech.2010.04.039
	CHEMBL275149	97886	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	565	12	1	7	5.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)N(Cc4ccccc4)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.ejmech.2010.04.039
	11508049	161421	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	321	4	1	5	4.3	CCn1c(-c2ccccc2)nc2c(NC3CCCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4159165	161421	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	321	4	1	5	4.3	CCn1c(-c2ccccc2)nc2c(NC3CCCCC3)ncnc21	10.1016/j.ejmech.2018.03.067
	2153	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm049418o
	2620	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm049418o
	413	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm049418o
	CHEMBL190	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm049418o
	DB00277	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human Adenosine A2b receptorAntagonist activity against human Adenosine A2b receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm049418o
	2153	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2010.04.039
	2620	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2010.04.039
	413	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2010.04.039
	CHEMBL190	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2010.04.039
	DB00277	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity against human adenosine A2B receptorAntagonist activity against human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2010.04.039
	2153	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2021.113907
	2620	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2021.113907
	413	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2021.113907
	CHEMBL190	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2021.113907
	DB00277	3728	108	None	-	4	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2021.113907
	11681354	162374	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	323	5	1	6	3.1	CCCn1c(-c2ccccc2)nc2c(NC3CCOC3)ncnc21	10.1016/j.ejmech.2018.03.067
	CHEMBL4174308	162374	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assayAntagonist activity at recombinant human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced adenylyl cyclase activity after 20 mins by [alpha-32P]ATP assay	ChEMBL	323	5	1	6	3.1	CCCn1c(-c2ccccc2)nc2c(NC3CCOC3)ncnc21	10.1016/j.ejmech.2018.03.067
	72197701	90350	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	375	5	1	6	4.3	O=C(Nc1nc(-c2ccccc2)c(C(=O)c2ccccn2)s1)c1ccco1	10.1016/j.ejmech.2013.03.020
	CHEMBL2391831	90350	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	375	5	1	6	4.3	O=C(Nc1nc(-c2ccccc2)c(C(=O)c2ccccn2)s1)c1ccco1	10.1016/j.ejmech.2013.03.020
	18440431	136108	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	296	6	2	6	2.5	CCCn1cnc2c(N)nc(NCCc3ccccc3)nc21	10.1039/C5MD00034C
	CHEMBL3739985	136108	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	296	6	2	6	2.5	CCCn1cnc2c(N)nc(NCCc3ccccc3)nc21	10.1039/C5MD00034C
	127042994	136252	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	347	7	1	6	4.2	CCCn1c(-c2ccco2)nc2c(NCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	CHEMBL3741337	136252	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL	347	7	1	6	4.2	CCCn1c(-c2ccco2)nc2c(NCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	71453891	82509	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	313	5	2	9	1.1	Cn1cc2c(nc(NCCCO)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181143	82509	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	313	5	2	9	1.1	Cn1cc2c(nc(NCCCO)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL5088372	213371	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assayAntagonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cell membrane assessed as inhibition of NECA-induced cAMP accumulation in presence of forskolin measured after 40 mins by alpha screen LANCE assay	ChEMBL		None	None	None		CCCCn1c(=O)c2nc(C34CCC(C(=O)NCCOCCOCCOCCN=[N+]=[N-])(CC3)CC4)[nH]c2n(CCCNC(=O)c2ccc(S(=O)(=O)F)cc2)c1=O	10.1021/acs.jmedchem.0c02169
	71462775	82531	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	351	4	1	8	3.3	Cn1cc2c(nc(NCC3CCCCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	CHEMBL2181164	82531	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	351	4	1	8	3.3	Cn1cc2c(nc(NCC3CCCCC3)n3nc(-c4ccco4)nc23)n1	10.1021/jm300899q
	71457404	82515	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	297	3	1	8	2.1	CC(C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	CHEMBL2181149	82515	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	297	3	1	8	2.1	CC(C)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm300899q
	71455604	82498	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	375	5	1	9	2.9	COc1ccc(CNc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm300899q
	CHEMBL2180934	82498	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activityAntagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as NECA-induced adenylate cyclase activity	ChEMBL	375	5	1	9	2.9	COc1ccc(CNc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm300899q
	162657141	180331	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human A2B receptor expressed in CHO cell membrane assessed as reduction in NECA-stimulated adenylyl cyclase activity in presence of [alpha32P]ATPAntagonist activity at human A2B receptor expressed in CHO cell membrane assessed as reduction in NECA-stimulated adenylyl cyclase activity in presence of [alpha32P]ATP	ChEMBL	371	6	2	11	0.6	CCOC(=O)C(CO)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1039/d0md00380h
	CHEMBL4757966	180331	0	None	-	0	Human	5.0	pKi	=	5.0	Functional	Antagonist activity at human A2B receptor expressed in CHO cell membrane assessed as reduction in NECA-stimulated adenylyl cyclase activity in presence of [alpha32P]ATPAntagonist activity at human A2B receptor expressed in CHO cell membrane assessed as reduction in NECA-stimulated adenylyl cyclase activity in presence of [alpha32P]ATP	ChEMBL	371	6	2	11	0.6	CCOC(=O)C(CO)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1039/d0md00380h
	2690	888	59	None	-31	5	Human	7.8	pA2	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	8937736
	384	888	59	None	-31	5	Human	7.8	pA2	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	8937736
	CHEMBL16687	888	59	None	-31	5	Human	7.8	pA2	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	8937736
	404	4023	30	None	1318	2	Human	7.9	pA2	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	8937736
	432	4023	30	None	1318	2	Human	7.9	pA2	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	8937736
	5697	4023	30	None	1318	2	Human	7.9	pA2	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	8937736
	CHEMBL273094	4023	30	None	1318	2	Human	7.9	pA2	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	8937736
	2844	280	103	None	-31	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	60961	280	103	None	-31	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	90	280	103	None	-31	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	CHEMBL477	280	103	None	-31	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	DB00640	280	103	None	-31	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	219024	3236	61	None	-51	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	Drug Central	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	None
	2362	3236	61	None	-51	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	Drug Central	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	None
	5596	3236	61	None	-51	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	Drug Central	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	None
	CHEMBL317052	3236	61	None	-51	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	Drug Central	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	None
	DB06213	3236	61	None	-51	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant adenosine receptor A2b by cAMP assayAgonist activity at human recombinant adenosine receptor A2b by cAMP assay	Drug Central	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	None
	11224	575	28	None	-6	7	Mouse	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906
	118016229	575	28	None	-6	7	Mouse	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906
	CHEMBL4522981	575	28	None	-6	7	Mouse	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906
	11224	575	28	None	-4	7	Rat	6.6	pIC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906
	118016229	575	28	None	-4	7	Rat	6.6	pIC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906
	CHEMBL4522981	575	28	None	-4	7	Rat	6.6	pIC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10981286	1880	24	None	-28183	4	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	10.1021/jm0109762
	5599	1880	24	None	-28183	4	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	10.1021/jm0109762
	5736	1880	24	None	-28183	4	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	10.1021/jm0109762
	CHEMBL260563	1880	24	None	-28183	4	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	10.1021/jm0109762
	11014608	95899	0	None	-	3	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	389	6	4	9	0.8	CCCCC#Cc1nc(NC(C)C)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1	10.1021/jm0109762
	CHEMBL261623	95899	0	None	-	3	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	389	6	4	9	0.8	CCCCC#Cc1nc(NC(C)C)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1	10.1021/jm0109762
	10020580	107474	4	None	-	5	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	347	4	4	9	-0.4	CCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1	10.1021/jm0109762
	CHEMBL319387	107474	4	None	-	5	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	347	4	4	9	-0.4	CCCCC#Cc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1	10.1021/jm0109762
	11112381	158882	0	None	-	3	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	411	4	5	10	-0.4	CNc1nc(C#C[C@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL410115	158882	0	None	-	3	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	411	4	5	10	-0.4	CNc1nc(C#C[C@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	10970819	168259	0	None	-	3	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	375	6	4	9	0.4	CCCCC#Cc1nc(NCC)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1	10.1021/jm0109762
	CHEMBL437842	168259	0	None	-	3	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	375	6	4	9	0.4	CCCCC#Cc1nc(NCC)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1	10.1021/jm0109762
	11068963	196434	1	None	-	3	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	381	3	4	9	-0.1	CNc1nc(C#Cc2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL574597	196434	1	None	-	3	Human	4.0	pEC50	=	4	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	381	3	4	9	-0.1	CNc1nc(C#Cc2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	9932840	77530	1	None	-	4	Human	6.0	pEC50	=	6.0	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	438	4	5	10	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#CC(O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm0109762
	CHEMBL2094083	77530	1	None	-	4	Human	6.0	pEC50	=	6.0	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	438	4	5	10	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#CC(O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm0109762
	377	2707	47	None	-1479	15	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human A2B adenosine receptor by cell based assayAgonist activity at human A2B adenosine receptor by cell based assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.8b01662
	425	2707	47	None	-1479	15	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human A2B adenosine receptor by cell based assayAgonist activity at human A2B adenosine receptor by cell based assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.8b01662
	448222	2707	47	None	-1479	15	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human A2B adenosine receptor by cell based assayAgonist activity at human A2B adenosine receptor by cell based assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.8b01662
	CHEMBL464859	2707	47	None	-1479	15	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human A2B adenosine receptor by cell based assayAgonist activity at human A2B adenosine receptor by cell based assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.8b01662
	377	2707	47	None	-1479	15	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	425	2707	47	None	-1479	15	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	448222	2707	47	None	-1479	15	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	CHEMBL464859	2707	47	None	-1479	15	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	70682890	77446	5	None	-	3	Human	5.8	pEC50	=	5.8	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	425	5	5	10	-0.0	CCNc1nc(C#CC(O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL2092788	77446	5	None	-	3	Human	5.8	pEC50	=	5.8	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	425	5	5	10	-0.0	CCNc1nc(C#CC(O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	23757284	84691	0	None	-	3	Human	6.7	pEC50	=	6.7	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	438	4	5	10	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#C[C@@H](O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm0109762
	CHEMBL224874	84691	0	None	-	3	Human	6.7	pEC50	=	6.7	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	438	4	5	10	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#C[C@@H](O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm0109762
	25268841	8558	9	None	-	3	Human	6.6	pEC50	=	6.6	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells using [3H]PSB-603 by functional activity assayBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells using [3H]PSB-603 by functional activity assay	ChEMBL	402	5	1	7	2.6	Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCN3CCOCC3)ccc1C2=O	10.1021/acs.jmedchem.0c00914
	CHEMBL1095488	8558	9	None	-	3	Human	6.6	pEC50	=	6.6	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells using [3H]PSB-603 by functional activity assayBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells using [3H]PSB-603 by functional activity assay	ChEMBL	402	5	1	7	2.6	Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCN3CCOCC3)ccc1C2=O	10.1021/acs.jmedchem.0c00914
	13830108	77467	1	None	-	4	Human	5.6	pEC50	=	5.6	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	397	3	5	10	-0.9	Nc1nc(C#CC(O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL2092941	77467	1	None	-	4	Human	5.6	pEC50	=	5.6	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	397	3	5	10	-0.9	Nc1nc(C#CC(O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	23900137	95308	0	None	-	3	Human	5.6	pEC50	=	5.6	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	438	4	5	10	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#C[C@H](O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm0109762
	CHEMBL258534	95308	0	None	-	3	Human	5.6	pEC50	=	5.6	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	438	4	5	10	-0.8	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)nc(C#C[C@H](O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1021/jm0109762
	2844	280	103	None	-467	8	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at A2B receptor (unknown origin)Agonist activity at A2B receptor (unknown origin)	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.0c01431
	60961	280	103	None	-467	8	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at A2B receptor (unknown origin)Agonist activity at A2B receptor (unknown origin)	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.0c01431
	90	280	103	None	-467	8	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at A2B receptor (unknown origin)Agonist activity at A2B receptor (unknown origin)	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.0c01431
	CHEMBL477	280	103	None	-467	8	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at A2B receptor (unknown origin)Agonist activity at A2B receptor (unknown origin)	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.0c01431
	DB00640	280	103	None	-467	8	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at A2B receptor (unknown origin)Agonist activity at A2B receptor (unknown origin)	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.0c01431
	11026001	95867	0	None	-	3	Human	5.6	pEC50	=	5.6	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	411	4	5	10	-0.4	CNc1nc(C#C[C@@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL261453	95867	0	None	-	3	Human	5.6	pEC50	=	5.6	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	411	4	5	10	-0.4	CNc1nc(C#C[C@@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	69427076	77444	0	None	-	3	Human	5.6	pEC50	=	5.6	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	411	4	5	10	-0.4	CNc1nc(C#CC(O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL2092786	77444	0	None	-	3	Human	5.6	pEC50	=	5.6	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	411	4	5	10	-0.4	CNc1nc(C#CC(O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	377	2707	47	None	-1479	15	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsAgonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1007/s00044-004-0013-y
	425	2707	47	None	-1479	15	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsAgonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1007/s00044-004-0013-y
	448222	2707	47	None	-1479	15	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsAgonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1007/s00044-004-0013-y
	CHEMBL464859	2707	47	None	-1479	15	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsAgonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1007/s00044-004-0013-y
	2844	280	103	None	-467	8	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	60961	280	103	None	-467	8	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	90	280	103	None	-467	8	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	CHEMBL477	280	103	None	-467	8	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	DB00640	280	103	None	-467	8	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b01402
	70697521	77445	0	None	-	3	Human	5.2	pEC50	=	5.2	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	439	5	5	10	0.3	CC(C)Nc1nc(C#CC(O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL2092787	77445	0	None	-	3	Human	5.2	pEC50	=	5.2	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	439	5	5	10	0.3	CC(C)Nc1nc(C#CC(O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	118719026	114923	0	None	-	5	Human	5.2	pEC50	=	5.2	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	582	13	4	8	2.1	CC(C)(C)OC(=O)C1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1	10.1021/jm0109762
	CHEMBL3350613	114923	0	None	-	5	Human	5.2	pEC50	=	5.2	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	582	13	4	8	2.1	CC(C)(C)OC(=O)C1CCCN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1	10.1021/jm0109762
	9978117	157763	0	None	-	3	Human	5.2	pEC50	=	5.2	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	397	3	5	10	-0.9	Nc1nc(C#C[C@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL408918	157763	0	None	-	3	Human	5.2	pEC50	=	5.2	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	397	3	5	10	-0.9	Nc1nc(C#C[C@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	123807	856	47	None	-13803	13	Human	4.1	pEC50	=	4.1	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/acs.jmedchem.5b01402
	374	856	47	None	-13803	13	Human	4.1	pEC50	=	4.1	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/acs.jmedchem.5b01402
	379	856	47	None	-13803	13	Human	4.1	pEC50	=	4.1	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/acs.jmedchem.5b01402
	CHEMBL284969	856	47	None	-13803	13	Human	4.1	pEC50	=	4.1	Binding	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assayAgonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/acs.jmedchem.5b01402
	10455080	95309	0	None	-	3	Human	6.1	pEC50	=	6.1	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	425	5	5	10	-0.0	CCNc1nc(C#C[C@@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL258535	95309	0	None	-	3	Human	6.1	pEC50	=	6.1	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	425	5	5	10	-0.0	CCNc1nc(C#C[C@@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	11048438	168321	0	None	-	3	Human	5.1	pEC50	=	5.1	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	439	5	5	10	0.3	CC(C)Nc1nc(C#C[C@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL438418	168321	0	None	-	3	Human	5.1	pEC50	=	5.1	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	439	5	5	10	0.3	CC(C)Nc1nc(C#C[C@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	11112711	158862	0	None	-	3	Human	5.0	pEC50	=	5.0	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	425	5	5	10	-0.0	CCNc1nc(C#C[C@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL410095	158862	0	None	-	3	Human	5.0	pEC50	=	5.0	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	425	5	5	10	-0.0	CCNc1nc(C#C[C@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	44450290	96015	0	None	-	3	Human	6.0	pEC50	=	6.0	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	397	3	5	10	-0.9	Nc1nc(C#C[C@@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL262363	96015	0	None	-	3	Human	6.0	pEC50	=	6.0	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	397	3	5	10	-0.9	Nc1nc(C#C[C@@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	215492	16279	2	None	-	3	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human A2B adenosine receptor by cell based assayAgonist activity at human A2B adenosine receptor by cell based assay	ChEMBL	324	4	5	10	-2.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NCCO)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL1234591	16279	2	None	-	3	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human A2B adenosine receptor by cell based assayAgonist activity at human A2B adenosine receptor by cell based assay	ChEMBL	324	4	5	10	-2.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NCCO)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.8b01662
	10455852	95594	0	None	-	3	Human	6.0	pEC50	=	6.0	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	439	5	5	10	0.3	CC(C)Nc1nc(C#C[C@@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	CHEMBL259938	95594	0	None	-	3	Human	6.0	pEC50	=	6.0	Binding	Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligandReceptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand	ChEMBL	439	5	5	10	0.3	CC(C)Nc1nc(C#C[C@@H](O)c2ccccc2)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm0109762
	3284	3155	28	None	-1	7	Human	9.3	pIC50	=	9.3	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 60 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 60 mins by flow cytometric method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	44185871	3155	28	None	-1	7	Human	9.3	pIC50	=	9.3	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 60 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 60 mins by flow cytometric method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	5728	3155	28	None	-1	7	Human	9.3	pIC50	=	9.3	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 60 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 60 mins by flow cytometric method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	CHEMBL483688	3155	28	None	-1	7	Human	9.3	pIC50	=	9.3	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 60 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 60 mins by flow cytometric method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	3284	3155	28	None	-1	7	Human	9.1	pIC50	=	9.1	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	44185871	3155	28	None	-1	7	Human	9.1	pIC50	=	9.1	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	5728	3155	28	None	-1	7	Human	9.1	pIC50	=	9.1	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	CHEMBL483688	3155	28	None	-1	7	Human	9.1	pIC50	=	9.1	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01627
	16037920	168186	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	571	5	1	7	2.5	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL437309	168186	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	571	5	1	7	2.5	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	74944536	164026	3	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	540	7	0	7	2.8	CCCN1C(=O)N=C2N=C(c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)N=C2C1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4215606	164026	3	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	540	7	0	7	2.8	CCCN1C(=O)N=C2N=C(c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)N=C2C1=O	10.1021/acs.jmedchem.7b01627
	44413112	138762	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	511	5	1	7	1.9	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL379217	138762	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	511	5	1	7	1.9	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	134148336	147783	0	None	-	2	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]PSB603 from recombinant human adenosine A2B receptor expressed in HEK293 cell membranes after 1 hr by beta scintillation counting methodDisplacement of [3H]PSB603 from recombinant human adenosine A2B receptor expressed in HEK293 cell membranes after 1 hr by beta scintillation counting method	ChEMBL	395	4	2	4	5.7	O[C@H]1CC[C@H](Nc2ncc(-c3ccc4ccccc4c3)c(-c3ccccc3)n2)CC1	10.1016/j.ejmech.2016.09.081
	CHEMBL3937015	147783	0	None	-	2	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]PSB603 from recombinant human adenosine A2B receptor expressed in HEK293 cell membranes after 1 hr by beta scintillation counting methodDisplacement of [3H]PSB603 from recombinant human adenosine A2B receptor expressed in HEK293 cell membranes after 1 hr by beta scintillation counting method	ChEMBL	395	4	2	4	5.7	O[C@H]1CC[C@H](Nc2ncc(-c3ccc4ccccc4c3)c(-c3ccccc3)n2)CC1	10.1016/j.ejmech.2016.09.081
	44236568	155917	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	486	6	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4067401	155917	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	486	6	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	155552077	174845	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	496	6	1	9	2.6	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2Cc1nc2cc(S(N)(=O)=O)ccc2o1	10.1016/j.ejmech.2018.11.045
	CHEMBL4576194	174845	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	496	6	1	9	2.6	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2Cc1nc2cc(S(N)(=O)=O)ccc2o1	10.1016/j.ejmech.2018.11.045
	155542641	172573	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	424	8	0	8	2.7	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cn3ccnc3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4521489	172573	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	424	8	0	8	2.7	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cn3ccnc3)sc21	10.1016/j.ejmech.2018.11.045
	10237847	77091	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	411	4	2	7	1.4	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)Nc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL208705	77091	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	411	4	2	7	1.4	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)Nc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	10196517	77905	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	553	8	2	7	3.3	CCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccc(F)cc5)CC4)cc3)cc2n(CC)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL210969	77905	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	553	8	2	7	3.3	CCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccc(F)cc5)CC4)cc3)cc2n(CC)c1=O	10.1016/j.bmcl.2006.04.074
	155568402	175428	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	468	8	1	9	2.4	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(C)(O)c3cncn3C)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4589654	175428	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	468	8	1	9	2.4	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(C)(O)c3cncn3C)sc21	10.1016/j.ejmech.2018.11.045
	2690	888	59	None	-30	9	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm980094b
	384	888	59	None	-30	9	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm980094b
	CHEMBL16687	888	59	None	-30	9	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm980094b
	10812045	15331	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	419	7	1	7	2.9	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1	10.1039/C1MD00213A
	CHEMBL121766	15331	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	419	7	1	7	2.9	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2OC)CC1	10.1039/C1MD00213A
	44413202	77974	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	565	7	1	9	2.3	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)cc21	10.1016/j.bmcl.2006.04.074
	CHEMBL211071	77974	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	565	7	1	9	2.3	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)cc21	10.1016/j.bmcl.2006.04.074
	155527056	170565	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	366	5	1	6	2.5	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2Cc1ncc[nH]1	10.1016/j.ejmech.2018.11.045
	CHEMBL4458469	170565	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	366	5	1	6	2.5	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2Cc1ncc[nH]1	10.1016/j.ejmech.2018.11.045
	155550407	173349	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	325	4	0	6	2.3	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CC#N	10.1016/j.ejmech.2018.11.045
	CHEMBL4540909	173349	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	325	4	0	6	2.3	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CC#N	10.1016/j.ejmech.2018.11.045
	155525648	170517	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	366	5	1	6	2.5	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2Cc1cnc[nH]1	10.1016/j.ejmech.2018.11.045
	CHEMBL4457584	170517	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	366	5	1	6	2.5	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2Cc1cnc[nH]1	10.1016/j.ejmech.2018.11.045
	10766773	206369	0	None	-	3	Human	4.9	pIC50	=	4.9	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	356	4	2	7	2.5	NCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	CHEMBL97961	206369	0	None	-	3	Human	4.9	pIC50	=	4.9	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	356	4	2	7	2.5	NCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	155515805	169429	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	332	5	0	5	2.7	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CCF	10.1016/j.ejmech.2018.11.045
	CHEMBL4442438	169429	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	332	5	0	5	2.7	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CCF	10.1016/j.ejmech.2018.11.045
	155526484	170550	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	414	8	1	7	2.9	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(O)C3CC3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4458223	170550	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	414	8	1	7	2.9	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(O)C3CC3)sc21	10.1016/j.ejmech.2018.11.045
	10288169	79334	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	439	6	2	7	1.1	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCCc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL211762	79334	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	439	6	2	7	1.1	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCCc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	155515166	169353	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	380	5	0	7	2.6	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2Cc1nccn1C	10.1016/j.ejmech.2018.11.045
	CHEMBL4441343	169353	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	380	5	0	7	2.6	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2Cc1nccn1C	10.1016/j.ejmech.2018.11.045
	44413113	77900	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	539	7	1	7	2.8	CCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)cc2n(CC)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL210931	77900	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	539	7	1	7	2.8	CCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)cc2n(CC)c1=O	10.1016/j.bmcl.2006.04.074
	44413192	79508	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	483	8	2	8	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCc4ccc(OC)cn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL212528	79508	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	483	8	2	8	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCc4ccc(OC)cn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	122574772	170511	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	374	7	1	7	1.9	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(CO)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4457476	170511	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	374	7	1	7	1.9	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(CO)sc21	10.1016/j.ejmech.2018.11.045
	155548802	173226	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	428	8	1	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(C)(O)C3CC3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4538262	173226	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	428	8	1	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(C)(O)C3CC3)sc21	10.1016/j.ejmech.2018.11.045
	155562247	175140	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	370	6	0	6	2.9	COCCn1c(=O)n(CC2(c3ccccc3)CC2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4582620	175140	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	370	6	0	6	2.9	COCCn1c(=O)n(CC2(c3ccccc3)CC2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	10311222	77375	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	493	5	1	7	1.7	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL209019	77375	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	493	5	1	7	1.7	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	155521875	170031	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	310	4	0	6	2.2	COCCn1c(=O)n(CC(C)(C)C)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4450782	170031	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	310	4	0	6	2.2	COCCn1c(=O)n(CC(C)(C)C)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	10310578	77421	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	455	7	2	8	1.0	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCCOc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL209208	77421	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	455	7	2	8	1.0	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCCOc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	10238677	79490	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	467	8	2	7	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCCc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL212464	79490	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	467	8	2	7	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCCc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	44413193	139589	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	539	7	1	7	2.8	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)cc21	10.1016/j.bmcl.2006.04.074
	CHEMBL380177	139589	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	539	7	1	7	2.8	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)cc21	10.1016/j.bmcl.2006.04.074
	155523243	170257	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	469	7	1	7	2.7	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CCc1ccc(S(N)(=O)=O)cc1	10.1016/j.ejmech.2018.11.045
	CHEMBL4453664	170257	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	469	7	1	7	2.7	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CCc1ccc(S(N)(=O)=O)cc1	10.1016/j.ejmech.2018.11.045
	155533818	171320	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	416	8	0	8	2.6	CCOC(=O)c1sc2c(c1C)c(=O)n(CCc1ccccc1)c(=O)n2CCOC	10.1016/j.ejmech.2018.11.045
	CHEMBL4469697	171320	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	416	8	0	8	2.6	CCOC(=O)c1sc2c(c1C)c(=O)n(CCc1ccccc1)c(=O)n2CCOC	10.1016/j.ejmech.2018.11.045
	10577289	206323	0	None	-	3	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	384	6	2	7	3.3	NCCCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	CHEMBL97700	206323	0	None	-	3	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	384	6	2	7	3.3	NCCCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	10153029	77679	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	563	10	2	7	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL209944	77679	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	563	10	2	7	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmcl.2006.04.074
	10288197	77795	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	441	5	2	8	1.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)cn1	10.1016/j.bmcl.2006.04.074
	CHEMBL210456	77795	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	441	5	2	8	1.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)cn1	10.1016/j.bmcl.2006.04.074
	155521508	170127	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	370	5	0	6	3.0	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CC1CCCO1	10.1016/j.ejmech.2018.11.045
	CHEMBL4451942	170127	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	370	5	0	6	3.0	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CC1CCCO1	10.1016/j.ejmech.2018.11.045
	155555355	173860	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	452	8	0	9	2.4	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)c3cn(C)cn3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4553423	173860	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	452	8	0	9	2.4	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)c3cn(C)cn3)sc21	10.1016/j.ejmech.2018.11.045
	155551709	174561	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	438	8	1	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3nc[nH]c3C)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4569909	174561	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	438	8	1	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3nc[nH]c3C)sc21	10.1016/j.ejmech.2018.11.045
	44413182	77796	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	455	6	2	8	1.1	COc1ccc(CNS(=O)(=O)c2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)nc1	10.1016/j.bmcl.2006.04.074
	CHEMBL210457	77796	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	455	6	2	8	1.1	COc1ccc(CNS(=O)(=O)c2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)nc1	10.1016/j.bmcl.2006.04.074
	155521394	170013	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	443	7	1	8	1.2	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)N3CC(O)C3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4450633	170013	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	443	7	1	8	1.2	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)N3CC(O)C3)sc21	10.1016/j.ejmech.2018.11.045
	155523200	170178	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	427	8	0	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(CN3CCCC3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4452532	170178	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	427	8	0	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(CN3CCCC3)sc21	10.1016/j.ejmech.2018.11.045
	155526352	170637	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	358	6	0	6	2.7	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4459477	170637	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	358	6	0	6	2.7	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C)sc21	10.1016/j.ejmech.2018.11.045
	155543633	172621	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	405	4	1	7	1.3	CCn1c(=O)c2c(C)c(C(=O)N3CC(O)C3)sc2n(CCC(F)(F)F)c1=O	10.1016/j.ejmech.2018.11.045
	CHEMBL4522738	172621	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	405	4	1	7	1.3	CCn1c(=O)c2c(C)c(C(=O)N3CC(O)C3)sc2n(CCC(F)(F)F)c1=O	10.1016/j.ejmech.2018.11.045
	44236539	156239	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	460	7	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4070936	156239	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	460	7	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	10645984	18614	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	423	6	1	6	3.6	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1	10.1039/C1MD00213A
	CHEMBL127876	18614	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	423	6	1	6	3.6	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2cccc(Cl)c2)CC1	10.1039/C1MD00213A
	155549589	173335	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	362	6	0	6	2.6	COCCn1c(=O)n(CCc2ccccc2F)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4540558	173335	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	362	6	0	6	2.6	COCCn1c(=O)n(CCc2ccccc2F)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	118016325	169495	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	388	7	1	7	2.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)O)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4443243	169495	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	388	7	1	7	2.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)O)sc21	10.1016/j.ejmech.2018.11.045
	155514761	169313	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	294	4	0	6	1.4	CCn1c(=O)c2c3c(sc2n(CCOC)c1=O)CCC3	10.1016/j.ejmech.2018.11.045
	CHEMBL4440686	169313	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	294	4	0	6	1.4	CCn1c(=O)c2c3c(sc2n(CCOC)c1=O)CCC3	10.1016/j.ejmech.2018.11.045
	45073485	163054	6	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	506	7	0	7	2.2	CCCN1C(=O)N=C2N=C(c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)N=C2C1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4203745	163054	6	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	506	7	0	7	2.2	CCCN1C(=O)N=C2N=C(c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)N=C2C1=O	10.1021/acs.jmedchem.7b01627
	155562338	175264	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	448	8	0	7	3.7	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)c3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4585480	175264	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	448	8	0	7	3.7	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)c3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	10474279	106813	0	None	-	3	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	369	2	1	6	4.2	CC(C)(C)C(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	CHEMBL317310	106813	0	None	-	3	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	369	2	1	6	4.2	CC(C)(C)C(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	10691504	206036	0	None	-	3	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	385	2	1	7	4.5	CC(C)(C)OC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	CHEMBL96041	206036	0	None	-	3	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	385	2	1	7	4.5	CC(C)(C)OC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	10669778	116959	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	419	7	1	7	2.9	COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1	10.1039/C1MD00213A
	CHEMBL339936	116959	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	419	7	1	7	2.9	COc1ccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)cc1	10.1039/C1MD00213A
	155522968	170192	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	442	9	0	7	3.9	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(COC3CCCC3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4452799	170192	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	442	9	0	7	3.9	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(COC3CCCC3)sc21	10.1016/j.ejmech.2018.11.045
	155558166	174172	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	441	7	0	7	2.7	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)N3CCCC3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4560841	174172	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	441	7	0	7	2.7	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)N3CCCC3)sc21	10.1016/j.ejmech.2018.11.045
	71600087	153811	46	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	459	6	2	5	4.4	CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1	10.1021/acs.jmedchem.7b00746
	CHEMBL3987016	153811	46	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	459	6	2	5	4.4	CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1	10.1021/acs.jmedchem.7b00746
	10616222	106947	0	None	-	3	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	327	2	1	6	3.1	CC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	CHEMBL318251	106947	0	None	-	3	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	327	2	1	6	3.1	CC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	44413130	79533	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	494	5	1	8	1.1	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccncc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL212642	79533	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	494	5	1	8	1.1	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccncc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	10339165	206000	0	None	-2	4	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	370	5	2	7	2.9	NCCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	CHEMBL95811	206000	0	None	-2	4	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	370	5	2	7	2.9	NCCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	135418256	15378	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of specific [3H]DPCPX binding at human adenosine A2B receptor expressed in HEK293 cells.Displacement of specific [3H]DPCPX binding at human adenosine A2B receptor expressed in HEK293 cells.	ChEMBL	326	4	1	5	3.7	CCCCc1nc2[nH]ncc2c2nc(-c3ccc(Cl)cc3)nn12	10.1016/j.bmcl.2004.04.099
	CHEMBL122037	15378	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of specific [3H]DPCPX binding at human adenosine A2B receptor expressed in HEK293 cells.Displacement of specific [3H]DPCPX binding at human adenosine A2B receptor expressed in HEK293 cells.	ChEMBL	326	4	1	5	3.7	CCCCc1nc2[nH]ncc2c2nc(-c3ccc(Cl)cc3)nn12	10.1016/j.bmcl.2004.04.099
	11224	575	28	None	-	1	Rat	6.6	pIC50	=	6.6	Binding	Antagonist activity at recombinant rat A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant rat A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	118016229	575	28	None	-	1	Rat	6.6	pIC50	=	6.6	Binding	Antagonist activity at recombinant rat A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant rat A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	CHEMBL4522981	575	28	None	-	1	Rat	6.6	pIC50	=	6.6	Binding	Antagonist activity at recombinant rat A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant rat A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	155548182	173206	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	345	6	0	7	1.8	COCCn1c(=O)n(CCc2cccnc2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4537687	173206	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	345	6	0	7	1.8	COCCn1c(=O)n(CCc2cccnc2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	155536243	171604	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	470	8	0	6	4.6	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(F)(F)c3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4473551	171604	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	470	8	0	6	4.6	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(F)(F)c3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	1329	1439	78	None	-1288	14	Human	8.4	pIC50	=	8.4	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.7b01627
	386	1439	78	None	-1288	14	Human	8.4	pIC50	=	8.4	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.7b01627
	CHEMBL183	1439	78	None	-1288	14	Human	8.4	pIC50	=	8.4	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.7b01627
	DB12946	1439	78	None	-1288	14	Human	8.4	pIC50	=	8.4	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.7b01627
	155519860	169836	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	450	8	1	7	3.5	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(O)c3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4448231	169836	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	450	8	1	7	3.5	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(O)c3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	155544551	172812	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	344	6	0	6	2.4	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4528081	172812	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	344	6	0	6	2.4	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	449	2595	44	None	-1	9	Human	7.5	pIC50	=	7.5	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	nan
	453	2595	44	None	-1	9	Human	7.5	pIC50	=	7.5	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	nan
	6603931	2595	44	None	-1	9	Human	7.5	pIC50	=	7.5	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	nan
	CHEMBL273807	2595	44	None	-1	9	Human	7.5	pIC50	=	7.5	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	nan
	71601630	86480	0	None	-	2	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assayInhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assay	ChEMBL	225	1	1	5	1.7	Cc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1021/jm400068e
	CHEMBL2322916	86480	0	None	-	2	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assayInhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assay	ChEMBL	225	1	1	5	1.7	Cc1nc(N)c2nn(-c3ccccc3)cc2n1	10.1021/jm400068e
	155517038	169581	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	378	6	0	6	3.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cl)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4444370	169581	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	378	6	0	6	3.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cl)sc21	10.1016/j.ejmech.2018.11.045
	155541364	172411	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	380	5	1	6	2.9	Cc1[nH]cnc1Cn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4517977	172411	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	380	5	1	6	2.9	Cc1[nH]cnc1Cn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	10717193	16588	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	423	6	1	6	3.6	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1	10.1039/C1MD00213A
	CHEMBL124485	16588	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	423	6	1	6	3.6	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccc(Cl)cc2)CC1	10.1039/C1MD00213A
	155526277	170542	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	449	7	1	7	2.7	CCN(CC(C)(C)O)C(=O)c1sc2c(c1C)c(=O)n(CC)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	CHEMBL4458042	170542	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	449	7	1	7	2.7	CCN(CC(C)(C)O)C(=O)c1sc2c(c1C)c(=O)n(CC)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	155522797	170224	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	308	4	0	6	1.8	CCn1c(=O)c2c3c(sc2n(CCOC)c1=O)CCCC3	10.1016/j.ejmech.2018.11.045
	CHEMBL4453228	170224	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	308	4	0	6	1.8	CCn1c(=O)c2c3c(sc2n(CCOC)c1=O)CCCC3	10.1016/j.ejmech.2018.11.045
	155548102	173136	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	431	8	0	8	2.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)N(C)OC)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4536104	173136	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	431	8	0	8	2.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)N(C)OC)sc21	10.1016/j.ejmech.2018.11.045
	10218183	79341	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	533	5	1	8	2.5	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)s5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL211813	79341	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	533	5	1	8	2.5	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)s5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	11224	575	28	None	-	1	Mouse	6.4	pIC50	=	6.4	Binding	Antagonist activity at recombinant mouse A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant mouse A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	118016229	575	28	None	-	1	Mouse	6.4	pIC50	=	6.4	Binding	Antagonist activity at recombinant mouse A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant mouse A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	CHEMBL4522981	575	28	None	-	1	Mouse	6.4	pIC50	=	6.4	Binding	Antagonist activity at recombinant mouse A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant mouse A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	1922	201121	39	None	-26	6	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against cyclic AMP production in human Adenosine A2B receptor assayInhibitory activity against cyclic AMP production in human Adenosine A2B receptor assay	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm990499b
	CHEMBL62350	201121	39	None	-26	6	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against cyclic AMP production in human Adenosine A2B receptor assayInhibitory activity against cyclic AMP production in human Adenosine A2B receptor assay	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm990499b
	155520492	169904	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	443	9	0	7	2.9	CCN(CC)C(=O)c1sc2c(c1C)c(=O)n(CCc1ccccc1)c(=O)n2CCOC	10.1016/j.ejmech.2018.11.045
	CHEMBL4449139	169904	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	443	9	0	7	2.9	CCN(CC)C(=O)c1sc2c(c1C)c(=O)n(CCc1ccccc1)c(=O)n2CCOC	10.1016/j.ejmech.2018.11.045
	71601632	86482	0	None	-	2	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assayInhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assay	ChEMBL	301	3	1	5	3.0	Nc1nc(Cc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1021/jm400068e
	CHEMBL2322918	86482	0	None	-	2	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assayInhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assay	ChEMBL	301	3	1	5	3.0	Nc1nc(Cc2ccccc2)nc2cn(-c3ccccc3)nc12	10.1021/jm400068e
	44413136	78842	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	6	2	7	2.2	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL211347	78842	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	6	2	7	2.2	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	155518555	169715	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	387	7	1	7	1.5	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(N)=O)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4446433	169715	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	387	7	1	7	1.5	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(N)=O)sc21	10.1016/j.ejmech.2018.11.045
	155537687	171755	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	380	6	0	6	3.0	COCCn1c(=O)n(CC(F)(F)c2ccccc2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4475483	171755	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	380	6	0	6	3.0	COCCn1c(=O)n(CC(F)(F)c2ccccc2)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	155560676	174533	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	282	4	0	6	1.5	CCn1c(=O)c2c(C)c(C)sc2n(CCOC)c1=O	10.1016/j.ejmech.2018.11.045
	CHEMBL4569387	174533	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	282	4	0	6	1.5	CCn1c(=O)c2c(C)c(C)sc2n(CCOC)c1=O	10.1016/j.ejmech.2018.11.045
	71601631	86481	0	None	-	2	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assayInhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assay	ChEMBL	287	2	1	5	3.1	Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12	10.1021/jm400068e
	CHEMBL2322917	86481	0	None	-	2	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assayInhibition of human A2B adenosine receptor transfected in CHO cells assessed as inhibition of NECA-induced cyclic AMP production after 10 mins by competitive protein binding assay	ChEMBL	287	2	1	5	3.1	Nc1nc(-c2ccccc2)nc2cn(-c3ccccc3)nc12	10.1021/jm400068e
	155512463	169057	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	330	6	0	6	2.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2ccsc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4437132	169057	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	330	6	0	6	2.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2ccsc21	10.1016/j.ejmech.2018.11.045
	59351824	173444	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	286	3	1	4	2.3	Cc1csc2[nH]c(=O)n(CCc3ccccc3)c(=O)c12	10.1016/j.ejmech.2018.11.045
	CHEMBL4543255	173444	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	286	3	1	4	2.3	Cc1csc2[nH]c(=O)n(CCc3ccccc3)c(=O)c12	10.1016/j.ejmech.2018.11.045
	155537810	171752	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	384	6	0	6	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c3c(sc21)CCCC3	10.1016/j.ejmech.2018.11.045
	CHEMBL4475461	171752	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	384	6	0	6	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c3c(sc21)CCCC3	10.1016/j.ejmech.2018.11.045
	155520204	169889	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	420	7	0	6	4.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(-c3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4448896	169889	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	420	7	0	6	4.1	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(-c3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	155559377	174266	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	316	5	0	6	2.0	COCCn1c(=O)n(CC=C(F)F)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4562969	174266	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	316	5	0	6	2.0	COCCn1c(=O)n(CC=C(F)F)c(=O)c2c(C)csc21	10.1016/j.ejmech.2018.11.045
	11796362	114590	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	419	7	1	7	2.9	COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1	10.1039/C1MD00213A
	CHEMBL334325	114590	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	419	7	1	7	2.9	COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1	10.1039/C1MD00213A
	155529645	170852	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	421	7	1	7	2.0	CCN(CCO)C(=O)c1sc2c(c1C)c(=O)n(CC)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	CHEMBL4462879	170852	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	421	7	1	7	2.0	CCN(CCO)C(=O)c1sc2c(c1C)c(=O)n(CC)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	155521508	170127	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	370	5	0	6	3.0	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CC1CCCO1	10.1016/j.ejmech.2018.11.045
	CHEMBL4451942	170127	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	370	5	0	6	3.0	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CC1CCCO1	10.1016/j.ejmech.2018.11.045
	155551418	173381	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	434	8	0	6	4.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4541543	173381	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	434	8	0	6	4.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3ccccc3)sc21	10.1016/j.ejmech.2018.11.045
	155569093	175420	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	383	5	0	6	3.1	Cc1csc2c1c(=O)n(CCc1cccnc1)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	CHEMBL4589448	175420	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	383	5	0	6	3.1	Cc1csc2c1c(=O)n(CCc1cccnc1)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	155537122	171689	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	382	5	0	5	3.7	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	CHEMBL4474572	171689	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	382	5	0	5	3.7	Cc1csc2c1c(=O)n(CCc1ccccc1)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	10550242	17060	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	423	6	1	6	3.6	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1	10.1039/C1MD00213A
	CHEMBL125670	17060	0	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	423	6	1	6	3.6	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2Cl)CC1	10.1039/C1MD00213A
	11224	575	28	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	118016229	575	28	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	CHEMBL4522981	575	28	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	44413154	77636	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	4	1	7	1.7	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL209742	77636	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	4	1	7	1.7	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	44413106	79477	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	546	7	1	8	2.5	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C#N)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL212416	79477	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	546	7	1	8	2.5	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C#N)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	2690	888	59	None	-30	9	Human	7.2	pIC50	=	7.2	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/acs.jmedchem.7b01627
	384	888	59	None	-30	9	Human	7.2	pIC50	=	7.2	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/acs.jmedchem.7b01627
	CHEMBL16687	888	59	None	-30	9	Human	7.2	pIC50	=	7.2	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/acs.jmedchem.7b01627
	122574669	175249	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	268	4	0	6	1.2	CCn1c(=O)c2c(C)csc2n(CCOC)c1=O	10.1016/j.ejmech.2018.11.045
	CHEMBL4585015	175249	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	268	4	0	6	1.2	CCn1c(=O)c2c(C)csc2n(CCOC)c1=O	10.1016/j.ejmech.2018.11.045
	10645103	163778	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	407	6	1	6	3.0	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1	10.1039/C1MD00213A
	CHEMBL421256	163778	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at adenosine A2B receptor (unknown origin)Antagonist activity at adenosine A2B receptor (unknown origin)	ChEMBL	407	6	1	6	3.0	COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2F)CC1	10.1039/C1MD00213A
	11224	575	28	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at recombinant human A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant human A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	118016229	575	28	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at recombinant human A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant human A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	CHEMBL4522981	575	28	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at recombinant human A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assayAntagonist activity at recombinant human A2B adenosine receptor expressed in CHO cells after 3 to 4 hrs by luciferase reporter gene assay	ChEMBL	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	10.1016/j.ejmech.2018.11.045
	10193	2949	30	None	-46	4	Human	6.2	pIC50	=	6.2	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	305	2	1	7	1.2	Nc1nc(nc(c1Br)n1cccn1)n1cccn1	nan
	53466958	2949	30	None	-46	4	Human	6.2	pIC50	=	6.2	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	305	2	1	7	1.2	Nc1nc(nc(c1Br)n1cccn1)n1cccn1	nan
	CHEMBL3638684	2949	30	None	-46	4	Human	6.2	pIC50	=	6.2	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	305	2	1	7	1.2	Nc1nc(nc(c1Br)n1cccn1)n1cccn1	nan
	CHEMBL3694769	2949	30	None	-46	4	Human	6.2	pIC50	=	6.2	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	305	2	1	7	1.2	Nc1nc(nc(c1Br)n1cccn1)n1cccn1	nan
	44413125	77708	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	529	5	1	7	2.0	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5F)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL210088	77708	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	529	5	1	7	2.0	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5F)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	10196060	77775	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	511	5	1	7	1.9	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL210383	77775	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	511	5	1	7	1.9	Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmcl.2006.04.074
	155259564	184626	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	339	5	3	9	1.2	Nc1nc(NCCc2ccc(O)cc2)nc2nc(C3=CCCO3)nn12	nan
	CHEMBL4857871	184626	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assayInhibition of A2bR (unknown origin) expressed in HEK293 cells incubated overnight by dual luciferase reporter assay	ChEMBL	339	5	3	9	1.2	Nc1nc(NCCc2ccc(O)cc2)nc2nc(C3=CCCO3)nn12	nan
	155559834	174338	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	400	5	0	5	3.9	Cc1csc2c1c(=O)n(CCc1ccccc1F)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	CHEMBL4564912	174338	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	400	5	0	5	3.9	Cc1csc2c1c(=O)n(CCc1ccccc1F)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	10621961	206330	0	None	-	3	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	418	4	2	7	4.0	Nc1ccc(CC(=O)Nc2nc3ccc(Cl)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm980094b
	CHEMBL97748	206330	0	None	-	3	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptorInhibition of 50 uM 5`-(N-ethylcarboxamido)adenosine induced cAMP production in CHO cell line expressing human Adenosine A2B receptor	ChEMBL	418	4	2	7	4.0	Nc1ccc(CC(=O)Nc2nc3ccc(Cl)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm980094b
	44413096	138428	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	467	8	2	7	2.1	CCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCCc4ccccn4)cc3)cc2n(CC)c1=O	10.1016/j.bmcl.2006.04.074
	CHEMBL378527	138428	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	467	8	2	7	2.1	CCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NCCc4ccccn4)cc3)cc2n(CC)c1=O	10.1016/j.bmcl.2006.04.074
	155552481	173475	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	443	8	0	8	2.3	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(CN3CCOCC3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4544040	173475	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	443	8	0	8	2.3	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(CN3CCOCC3)sc21	10.1016/j.ejmech.2018.11.045
	155541183	172433	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	412	8	0	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)C3CC3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4518356	172433	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	412	8	0	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(C(=O)C3CC3)sc21	10.1016/j.ejmech.2018.11.045
	155553932	174867	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	438	8	1	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3c[nH]c(C)n3)sc21	10.1016/j.ejmech.2018.11.045
	CHEMBL4576817	174867	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	438	8	1	7	3.0	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3c[nH]c(C)n3)sc21	10.1016/j.ejmech.2018.11.045
	57429602	156685	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4076435	156685	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assayAntagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release incubated for 15 mins followed by agonist treatment for 15 mins by HTRF assay	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	44413142	77821	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	521	6	1	7	2.5	CN(C1CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.bmcl.2006.04.074
	CHEMBL210560	77821	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	521	6	1	7	2.5	CN(C1CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.bmcl.2006.04.074
	176407	4069	76	None	-34	6	Human	7.0	pIC50	=	7.0	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.7b01627
	405	4069	76	None	-34	6	Human	7.0	pIC50	=	7.0	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.7b01627
	CHEMBL113142	4069	76	None	-34	6	Human	7.0	pIC50	=	7.0	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.7b01627
	DB08770	4069	76	None	-34	6	Human	7.0	pIC50	=	7.0	Binding	Displacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric methodDisplacement of PSB-12105 from recombinant human adenosine A2B receptor expressed in CHO cell membranes preincubated for 30 mins followed by PSB-12105 addition measured after 20 mins by flow cytometric method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.7b01627
	135515408	116560	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of specific [3H]DPCPX binding at human adenosine A2B receptor expressed in HEK293 cells.Displacement of specific [3H]DPCPX binding at human adenosine A2B receptor expressed in HEK293 cells.	ChEMBL	310	4	1	5	3.1	CCCCc1nc2[nH]ncc2c2nc(-c3ccc(F)cc3)nn12	10.1016/j.bmcl.2004.04.099
	CHEMBL339218	116560	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of specific [3H]DPCPX binding at human adenosine A2B receptor expressed in HEK293 cells.Displacement of specific [3H]DPCPX binding at human adenosine A2B receptor expressed in HEK293 cells.	ChEMBL	310	4	1	5	3.1	CCCCc1nc2[nH]ncc2c2nc(-c3ccc(F)cc3)nn12	10.1016/j.bmcl.2004.04.099
	155540197	172323	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	370	6	0	6	2.6	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c3c(sc21)CCC3	10.1016/j.ejmech.2018.11.045
	CHEMBL4516075	172323	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	370	6	0	6	2.6	COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c3c(sc21)CCC3	10.1016/j.ejmech.2018.11.045
	155549654	173324	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	435	8	0	7	2.6	CCN(CC)C(=O)c1sc2c(c1C)c(=O)n(CCOC)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	CHEMBL4540250	173324	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assayDisplacement of [3H]DPCPX from human A2B adenosine receptor expressed in HEK293 cell membranes after 60 mins by radioligand displacement assay	ChEMBL	435	8	0	7	2.6	CCN(CC)C(=O)c1sc2c(c1C)c(=O)n(CCOC)c(=O)n2CCC(F)(F)F	10.1016/j.ejmech.2018.11.045
	450	2911	8	None	257	4	Human	9.8	pKd	=	9.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm900413e
	454	2911	8	None	257	4	Human	9.8	pKd	=	9.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm900413e
	5311041	2911	8	None	257	4	Human	9.8	pKd	=	9.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm900413e
	CHEMBL485862	2911	8	None	257	4	Human	9.8	pKd	=	9.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm900413e
	3284	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	Displacement of [3H]PSB-603 from mouse recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from mouse recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	44185871	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	Displacement of [3H]PSB-603 from mouse recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from mouse recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	5728	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	Displacement of [3H]PSB-603 from mouse recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from mouse recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	CHEMBL483688	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	Displacement of [3H]PSB-603 from mouse recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from mouse recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	3284	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by saturation experimentBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by saturation experiment	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	44185871	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by saturation experimentBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by saturation experiment	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	5728	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by saturation experimentBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by saturation experiment	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	CHEMBL483688	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by saturation experimentBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by saturation experiment	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	3284	3155	28	None	-1	7	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by kinetic experimentBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by kinetic experiment	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	44185871	3155	28	None	-1	7	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by kinetic experimentBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by kinetic experiment	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	5728	3155	28	None	-1	7	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by kinetic experimentBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by kinetic experiment	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	CHEMBL483688	3155	28	None	-1	7	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by kinetic experimentBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cells by kinetic experiment	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	449	2595	44	None	-1	9	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	453	2595	44	None	-1	9	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	6603931	2595	44	None	-1	9	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	CHEMBL273807	2595	44	None	-1	9	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	135484064	2568	3	None	21	4	Human	8.8	pKd	=	8.8	Binding	Binding affinity of [3H]-MRE 2029-F20 towards human adenosine A2b receptor expressed in CHO cellsBinding affinity of [3H]-MRE 2029-F20 towards human adenosine A2b receptor expressed in CHO cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.03.110
	390	2568	3	None	21	4	Human	8.8	pKd	=	8.8	Binding	Binding affinity of [3H]-MRE 2029-F20 towards human adenosine A2b receptor expressed in CHO cellsBinding affinity of [3H]-MRE 2029-F20 towards human adenosine A2b receptor expressed in CHO cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.03.110
	CHEMBL260331	2568	3	None	21	4	Human	8.8	pKd	=	8.8	Binding	Binding affinity of [3H]-MRE 2029-F20 towards human adenosine A2b receptor expressed in CHO cellsBinding affinity of [3H]-MRE 2029-F20 towards human adenosine A2b receptor expressed in CHO cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.03.110
	135484064	2568	3	None	21	4	Human	8.8	pKd	=	8.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm900413e
	390	2568	3	None	21	4	Human	8.8	pKd	=	8.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm900413e
	CHEMBL260331	2568	3	None	21	4	Human	8.8	pKd	=	8.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm900413e
	2690	888	59	None	-30	9	Human	8.0	pKd	=	8	Binding	pA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unitypA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unity	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm980094b
	384	888	59	None	-30	9	Human	8.0	pKd	=	8	Binding	pA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unitypA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unity	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm980094b
	CHEMBL16687	888	59	None	-30	9	Human	8.0	pKd	=	8	Binding	pA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unitypA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unity	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm980094b
	10339165	206000	0	None	-2	4	Human	8.0	pKd	=	8	Binding	pA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unitypA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unity	ChEMBL	370	5	2	7	2.9	NCCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	CHEMBL95811	206000	0	None	-2	4	Human	8.0	pKd	=	8	Binding	pA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unitypA2 value at human Adenosine A2B receptor from Schild plots with slopes approaching unity	ChEMBL	370	5	2	7	2.9	NCCCC(=O)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm980094b
	7064	116201	94	None	-70	4	Human	4.0	pKd	=	4.0	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	187	1	2	5	0.7	Nc1nc(N)nc(-c2ccccc2)n1	10.1021/acsmedchemlett.2c00099
	CHEMBL337319	116201	94	None	-70	4	Human	4.0	pKd	=	4.0	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	187	1	2	5	0.7	Nc1nc(N)nc(-c2ccccc2)n1	10.1021/acsmedchemlett.2c00099
	2727447	149892	7	None	-109	4	Human	3.9	pKd	=	3.9	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	211	1	1	5	1.4	Nc1ccc2nnc(-c3ccccc3)n2n1	10.1021/acsmedchemlett.2c00099
	CHEMBL3954022	149892	7	None	-109	4	Human	3.9	pKd	=	3.9	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	211	1	1	5	1.4	Nc1ccc2nnc(-c3ccccc3)n2n1	10.1021/acsmedchemlett.2c00099
	CHEMBL4550896	212237	5	None	-3	4	Human	3.9	pKd	=	3.9	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL		None	None	None		O=C(Nc1ccc2ccccc2n1)c1ccco1	10.1021/acsmedchemlett.2c00099
	2774349	32901	36	None	-1	4	Human	3.9	pKd	=	3.9	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	202	2	1	4	0.7	Cc1nn(-c2ccccc2)nc1C(N)=O	10.1021/acsmedchemlett.2c00099
	CHEMBL1417210	32901	36	None	-1	4	Human	3.9	pKd	=	3.9	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	202	2	1	4	0.7	Cc1nn(-c2ccccc2)nc1C(N)=O	10.1021/acsmedchemlett.2c00099
	2747546	191806	12	None	-2	4	Human	4.7	pKd	=	4.7	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	309	3	1	3	3.0	CS(=O)(=O)c1ccc(C(=O)Nc2cccc(Cl)c2)cc1	10.1021/acsmedchemlett.2c00099
	CHEMBL5208068	191806	12	None	-2	4	Human	4.7	pKd	=	4.7	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	309	3	1	3	3.0	CS(=O)(=O)c1ccc(C(=O)Nc2cccc(Cl)c2)cc1	10.1021/acsmedchemlett.2c00099
	2314144	50197	4	None	-1	4	Human	3.7	pKd	=	3.7	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	251	3	1	4	2.3	O=c1cc(NCc2ccccc2)nc2ccccn12	10.1021/acsmedchemlett.2c00099
	CHEMBL1573515	50197	4	None	-1	4	Human	3.7	pKd	=	3.7	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	251	3	1	4	2.3	O=c1cc(NCc2ccccc2)nc2ccccn12	10.1021/acsmedchemlett.2c00099
	2823411	190974	5	None	4	3	Human	4.7	pKd	=	4.7	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	253	3	1	4	2.2	O=C(NCc1ccccc1)c1ccc2nonc2c1	10.1021/acsmedchemlett.2c00099
	CHEMBL5195119	190974	5	None	4	3	Human	4.7	pKd	=	4.7	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	253	3	1	4	2.2	O=C(NCc1ccccc1)c1ccc2nonc2c1	10.1021/acsmedchemlett.2c00099
	9857146	184595	1	None	2	4	Human	6.6	pKd	=	6.6	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	289	2	0	3	4.2	Fc1ccc(-c2nn3ccccc3c2-c2ccncc2)cc1	10.1021/acsmedchemlett.2c00099
	CHEMBL485745	184595	1	None	2	4	Human	6.6	pKd	=	6.6	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	289	2	0	3	4.2	Fc1ccc(-c2nn3ccccc3c2-c2ccncc2)cc1	10.1021/acsmedchemlett.2c00099
	135543624	16118	20	None	-16	4	Human	5.5	pKd	=	5.5	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccc(O)cc1	10.1021/acsmedchemlett.2c00099
	CHEMBL122622	16118	20	None	-16	4	Human	5.5	pKd	=	5.5	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccc(O)cc1	10.1021/acsmedchemlett.2c00099
	221427	35091	32	None	-1	4	Human	4.4	pKd	=	4.4	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	213	2	2	2	2.7	O=C(Nc1ccccc1)Nc1ccccn1	10.1021/acsmedchemlett.2c00099
	CHEMBL143703	35091	32	None	-1	4	Human	4.4	pKd	=	4.4	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	213	2	2	2	2.7	O=C(Nc1ccccc1)Nc1ccccn1	10.1021/acsmedchemlett.2c00099
	2794757	190284	43	None	-2	4	Human	4.4	pKd	=	4.4	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	211	1	1	4	2.4	Nc1nsc(-c2ccc(Cl)cc2)n1	10.1021/acsmedchemlett.2c00099
	CHEMBL5184937	190284	43	None	-2	4	Human	4.4	pKd	=	4.4	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	211	1	1	4	2.4	Nc1nsc(-c2ccc(Cl)cc2)n1	10.1021/acsmedchemlett.2c00099
	CHEMBL5080679	212919	0	None	-3	4	Human	7.3	pKd	=	7.3	Binding	Binding affinity to NLuc human A2B adenosine receptor expressed in HEK293-A cells in presence of 1 uM PSB603 by NanoBRET binding assayBinding affinity to NLuc human A2B adenosine receptor expressed in HEK293-A cells in presence of 1 uM PSB603 by NanoBRET binding assay	ChEMBL		None	None	None		CCCn1c(=O)c2[nH]c(C34CC5CC(CC(C5)C3)C4)nc2n(CCCNC(=O)c2ccc(C(=O)NCCNC(=O)CCNC(=O)CCCCCNC(=O)COc3ccc(/C=C/C4=[N+]5C(=Cc6ccc(-c7cccs7)n6[B-]5(F)F)C=C4)cc3)cc2)c1=O	10.1021/acs.jmedchem.0c02067
	44583036	186362	0	None	7	5	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	10.1021/jm900413e
	CHEMBL490262	186362	0	None	7	5	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	10.1021/jm900413e
	CHEMBL521280	186362	0	None	7	5	Human	7.2	pKd	=	7.2	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	10.1021/jm900413e
	28561	180780	70	None	-1	4	Human	4.2	pKd	=	4.2	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	177	1	1	4	1.8	Nc1nc(-c2ccccc2)ns1	10.1021/acsmedchemlett.2c00099
	CHEMBL47633	180780	70	None	-1	4	Human	4.2	pKd	=	4.2	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	177	1	1	4	1.8	Nc1nc(-c2ccccc2)ns1	10.1021/acsmedchemlett.2c00099
	CHEMBL5075285	212585	0	None	-7	4	Human	8.1	pKd	=	8.1	Binding	Binding affinity to NLuc human A2B adenosine receptor expressed in HEK293-A cells in presence of 1 uM PSB603 by NanoBRET binding assayBinding affinity to NLuc human A2B adenosine receptor expressed in HEK293-A cells in presence of 1 uM PSB603 by NanoBRET binding assay	ChEMBL		None	None	None		CCCn1c(=O)c2[nH]c(C34CCC(C(=O)NCCNC(=O)CCNC(=O)CCNC(=O)CCCCCNC(=O)COc5ccc(/C=C/C6=[N+]7C(=Cc8ccc(-c9cccs9)n8[B-]7(F)F)C=C6)cc5)(CC3)CC4)nc2n(CCC)c1=O	10.1021/acs.jmedchem.0c02067
	17457984	191114	6	None	-2	2	Human	4.1	pKd	=	4.1	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	284	4	1	5	2.5	CC(C)n1ncc2cc(C(=O)NCc3ccco3)cnc21	10.1021/acsmedchemlett.2c00099
	CHEMBL5197070	191114	6	None	-2	2	Human	4.1	pKd	=	4.1	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay	ChEMBL	284	4	1	5	2.5	CC(C)n1ncc2cc(C(=O)NCc3ccco3)cnc21	10.1021/acsmedchemlett.2c00099
	136	3228	28	None	-77	16	Rat	7.0	pKd	=	7.0	Binding	Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus.Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus.	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00360a008
	223	3228	28	None	-77	16	Rat	7.0	pKd	=	7.0	Binding	Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus.Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus.	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00360a008
	643606	3228	28	None	-77	16	Rat	7.0	pKd	=	7.0	Binding	Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus.Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus.	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00360a008
	CHEMBL10347	3228	28	None	-77	16	Rat	7.0	pKd	=	7.0	Binding	Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus.Alpha-2 adrenergic receptor pA2 value against norepinephrine in vitro experiment in rat anococcygeus.	ChEMBL	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1021/jm00360a008
	155555721	173811	2	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	572	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Br)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4552275	173811	2	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	572	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Br)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155555721	173811	2	None	-1	2	Mouse	9.9	pKi	=	9.9	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	572	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Br)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4552275	173811	2	None	-1	2	Mouse	9.9	pKi	=	9.9	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	572	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Br)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155521543	170033	0	None	645	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	572	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5Br)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4450864	170033	0	None	645	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	572	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5Br)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155530514	170972	0	None	6	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	586	7	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Br)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4464522	170972	0	None	6	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	586	7	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Br)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155550159	173321	0	None	501	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	586	7	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4540206	173321	0	None	501	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	586	7	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44186666	185066	0	None	144	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486478	185066	0	None	144	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	155524032	170313	0	None	19054	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	620	6	2	7	2.6	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(I)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4454481	170313	0	None	19054	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	620	6	2	7	2.6	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(I)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	76328910	105029	0	None	-1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	522	8	1	8	2.9	Cn1c(=O)c2[nH]c(-c3ccc(OCCCN4CCN(Cc5ccccc5Cl)CC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	CHEMBL3121728	105029	0	None	-1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	522	8	1	8	2.9	Cn1c(=O)c2[nH]c(-c3ccc(OCCCN4CCN(Cc5ccccc5Cl)CC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	145977111	163202	0	None	7	4	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	617	9	3	7	3.9	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4205635	163202	0	None	7	4	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	617	9	3	7	3.9	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	44186580	183614	0	None	30	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL483261	183614	0	None	30	6	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	155529872	170930	0	None	165	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	558	7	2	8	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)c(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4463929	170930	0	None	165	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	558	7	2	8	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)c(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155532274	171121	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	572	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(Br)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4466625	171121	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	572	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(Br)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155560510	174466	0	None	851	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	549	8	2	8	2.9	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(N=[N+]=[N-])cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4567785	174466	0	None	851	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	549	8	2	8	2.9	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(N=[N+]=[N-])cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44186668	190904	0	None	245	6	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL519390	190904	0	None	245	6	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44186667	185067	0	None	478	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486479	185067	0	None	478	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	155528136	170681	0	None	158	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4460114	170681	0	None	158	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155545762	172897	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	558	7	2	8	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)c(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4530074	172897	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	558	7	2	8	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)c(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44186581	3144	23	None	851	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	10.1021/jm900413e
	6561	3144	23	None	851	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	10.1021/jm900413e
	CHEMBL482436	3144	23	None	851	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	10.1021/jm900413e
	155514860	169303	0	None	478	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	522	7	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4440526	169303	0	None	478	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	522	7	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	450	2911	8	None	257	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm201292w
	454	2911	8	None	257	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm201292w
	5311041	2911	8	None	257	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm201292w
	CHEMBL485862	2911	8	None	257	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm201292w
	155514957	169349	0	None	501	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5Cl)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4441276	169349	0	None	501	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5Cl)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44185870	183638	0	None	117	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	514	5	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL483487	183638	0	None	117	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	514	5	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	450	2911	8	None	257	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm900413e
	454	2911	8	None	257	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm900413e
	5311041	2911	8	None	257	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm900413e
	CHEMBL485862	2911	8	None	257	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/jm900413e
	155523968	170310	0	None	97	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	544	6	3	8	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)c(O)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4454417	170310	0	None	97	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	544	6	3	8	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)c(O)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155516277	169486	0	None	331	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	508	6	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5C)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4443090	169486	0	None	331	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	508	6	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5C)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44186626	184016	0	None	245	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL484900	184016	0	None	245	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44185872	190794	0	None	416	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	524	5	2	7	1.9	C#CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL519253	190794	0	None	416	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	524	5	2	7	1.9	C#CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	155561141	174392	0	None	676	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	604	7	2	7	2.9	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)c(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4566170	174392	0	None	676	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	604	7	2	7	2.9	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)c(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	450	2911	8	None	257	4	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01431
	454	2911	8	None	257	4	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01431
	5311041	2911	8	None	257	4	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01431
	CHEMBL485862	2911	8	None	257	4	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01431
	450	2911	8	None	257	4	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant A2B receptor expressed in HEK293 cell membranesBinding affinity to human recombinant A2B receptor expressed in HEK293 cell membranes	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b01340
	454	2911	8	None	257	4	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant A2B receptor expressed in HEK293 cell membranesBinding affinity to human recombinant A2B receptor expressed in HEK293 cell membranes	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b01340
	5311041	2911	8	None	257	4	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant A2B receptor expressed in HEK293 cell membranesBinding affinity to human recombinant A2B receptor expressed in HEK293 cell membranes	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b01340
	CHEMBL485862	2911	8	None	257	4	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant A2B receptor expressed in HEK293 cell membranesBinding affinity to human recombinant A2B receptor expressed in HEK293 cell membranes	ChEMBL	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b01340
	127033645	138577	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]OSIP339391 from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]OSIP339391 from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	526	10	3	7	3.0	CC(=O)NCCNc1nc(-c2ccccc2)nc2nc(C(=O)N3CCN(CCCc4ccccc4)CC3)[nH]c12	10.1021/acs.jmedchem.5b01586
	CHEMBL3786849	138577	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]OSIP339391 from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]OSIP339391 from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	526	10	3	7	3.0	CC(=O)NCCNc1nc(-c2ccccc2)nc2nc(C(=O)N3CCN(CCCc4ccccc4)CC3)[nH]c12	10.1021/acs.jmedchem.5b01586
	127033645	138577	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]OSIP339391 from human recombinant adenosine A2B receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]OSIP339391 from human recombinant adenosine A2B receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	526	10	3	7	3.0	CC(=O)NCCNc1nc(-c2ccccc2)nc2nc(C(=O)N3CCN(CCCc4ccccc4)CC3)[nH]c12	10.1021/acs.jmedchem.7b00138
	CHEMBL3786849	138577	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]OSIP339391 from human recombinant adenosine A2B receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]OSIP339391 from human recombinant adenosine A2B receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	526	10	3	7	3.0	CC(=O)NCCNc1nc(-c2ccccc2)nc2nc(C(=O)N3CCN(CCCc4ccccc4)CC3)[nH]c12	10.1021/acs.jmedchem.7b00138
	3284	3155	28	None	-1	7	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	44185871	3155	28	None	-1	7	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	5728	3155	28	None	-1	7	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	CHEMBL483688	3155	28	None	-1	7	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	10.1021/jm900413e
	44186624	191828	0	None	57	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL520830	191828	0	None	57	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	53324032	57708	0	None	165	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	352	4	1	4	3.8	O=C(Nc1cnc(-c2ccncc2F)c(-c2ccccc2F)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672631	57708	0	None	165	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	352	4	1	4	3.8	O=C(Nc1cnc(-c2ccncc2F)c(-c2ccccc2F)n1)C1CC1	10.1021/ml100249e
	44186582	183521	0	None	158	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL482638	183521	0	None	158	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	528	6	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	155525050	170402	0	None	316	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	524	7	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4456096	170402	0	None	316	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	524	7	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155530257	170946	0	None	213	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	556	8	2	8	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)c(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4464175	170946	0	None	213	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	556	8	2	8	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)c(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155531990	171132	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	512	6	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4466765	171132	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	512	6	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155564465	174675	0	None	190	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	494	6	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4572369	174675	0	None	190	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	494	6	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155534836	171421	0	None	165	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	512	6	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4471205	171421	0	None	165	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	512	6	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	168297247	191769	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	327	4	2	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(N=C=S)cc3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5207498	191769	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	327	4	2	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(N=C=S)cc3)[nH]c2c1=O	10.1039/d2md00132b
	168296088	191758	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	352	4	2	6	1.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)F)cc3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5207290	191758	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	352	4	2	6	1.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)F)cc3)[nH]c2c1=O	10.1039/d2md00132b
	44186625	184015	0	None	208	6	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	512	6	2	7	1.7	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL484899	184015	0	None	208	6	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	512	6	2	7	1.7	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	155530381	170988	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	508	6	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4464738	170988	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	508	6	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44186669	185205	0	None	354	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486688	185205	0	None	354	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44186622	183637	0	None	208	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL483469	183637	0	None	208	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	542	7	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44574165	188867	0	None	2	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	410	4	2	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL513681	188867	0	None	2	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	410	4	2	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	44186715	190615	0	None	54	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	522	7	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL518972	190615	0	None	54	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	522	7	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44186718	183581	0	None	117	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	538	6	2	9	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL483065	183581	0	None	117	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	538	6	2	9	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	155522541	170234	0	None	275	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	556	8	2	8	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)c(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4453324	170234	0	None	275	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	556	8	2	8	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)c(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44236421	156018	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	572	8	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4068507	156018	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	572	8	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	155530514	170972	0	None	-6	5	Mouse	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	586	7	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Br)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4464522	170972	0	None	-6	5	Mouse	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	586	7	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Br)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155531990	171132	0	None	-1	2	Mouse	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	512	6	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4466765	171132	0	None	-1	2	Mouse	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	512	6	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44186717	183553	0	None	89	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	538	8	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL482855	183553	0	None	89	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	538	8	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	76336198	105027	0	None	-13	2	Human	9.0	pKi	=	9	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	340	3	1	6	1.9	Cn1c(=O)c2[nH]c(-c3ccc(OC4CCCC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	CHEMBL3121726	105027	0	None	-13	2	Human	9.0	pKi	=	9	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	340	3	1	6	1.9	Cn1c(=O)c2[nH]c(-c3ccc(OC4CCCC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	135543624	16118	20	None	-16	4	Human	9.0	pKi	=	9	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assay	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccc(O)cc1	10.1021/acsmedchemlett.2c00099
	CHEMBL122622	16118	20	None	-16	4	Human	9.0	pKi	=	9	Binding	Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assayBinding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assay	ChEMBL	348	4	3	7	2.8	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccc(O)cc1	10.1021/acsmedchemlett.2c00099
	66894241	157259	0	None	114	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4083317	157259	0	None	114	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	66899873	158376	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	569	9	1	7	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)cc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4095766	158376	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	569	9	1	7	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)cc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44451166	95506	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	620	7	1	9	4.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL259479	95506	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	620	7	1	9	4.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	46866593	5848	0	None	151	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	323	4	1	4	3.9	O=C(Nc1ccc(-c2ccncc2F)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1079804	5848	0	None	151	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	323	4	1	4	3.9	O=C(Nc1ccc(-c2ccncc2F)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	46880424	5959	0	None	181	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	2	2	6	1.3	O=c1[nH]c(=O)c2cc(-c3ccncn3)c(-c3ccco3)nc2[nH]1	10.1016/j.bmcl.2010.01.077
	CHEMBL1080513	5959	0	None	181	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	2	2	6	1.3	O=c1[nH]c(=O)c2cc(-c3ccncn3)c(-c3ccco3)nc2[nH]1	10.1016/j.bmcl.2010.01.077
	46866591	6214	0	None	30	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	305	4	1	4	3.8	O=C(Nc1ccc(-c2ccncc2)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081812	6214	0	None	30	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	305	4	1	4	3.8	O=C(Nc1ccc(-c2ccncc2)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	16071901	57700	0	None	25	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	334	4	1	4	3.7	O=C(Nc1cnc(-c2ccncc2)c(-c2ccccc2F)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672623	57700	0	None	25	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	334	4	1	4	3.7	O=C(Nc1cnc(-c2ccncc2)c(-c2ccccc2F)n1)C1CC1	10.1021/ml100249e
	44587956	174190	0	None	-2	6	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	554	9	3	7	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL456125	174190	0	None	-2	6	Human	9.0	pKi	=	9	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	554	9	3	7	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	11705261	72630	0	None	371	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	460	8	1	10	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200779	72630	0	None	371	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	460	8	1	10	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	9822488	77257	0	None	691	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	404	3	1	7	1.9	Cn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(C)c1=O	10.1021/jm7014815
	CHEMBL208824	77257	0	None	691	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	404	3	1	7	1.9	Cn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(C)c1=O	10.1021/jm7014815
	9822488	77257	0	None	691	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	404	3	1	7	1.9	Cn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(C)c1=O	10.1021/jm051268+
	CHEMBL208824	77257	0	None	691	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	404	3	1	7	1.9	Cn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(C)c1=O	10.1021/jm051268+
	155532514	171191	0	None	154	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	556	8	2	8	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cc(F)cc(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4467573	171191	0	None	154	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	556	8	2	8	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cc(F)cc(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44451166	95506	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	620	7	1	9	4.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL259479	95506	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	620	7	1	9	4.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	76325371	105028	0	None	-25	4	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	380	6	1	8	1.3	Cn1c(=O)c2[nH]c(-c3ccc(OCCCn4ccnc4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	CHEMBL3121727	105028	0	None	-25	4	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	380	6	1	8	1.3	Cn1c(=O)c2[nH]c(-c3ccc(OCCCn4ccnc4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	44186719	185324	0	None	74	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	552	7	2	9	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486893	185324	0	None	74	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	552	7	2	9	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44186579	191178	0	None	131	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	494	6	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL519813	191178	0	None	131	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	494	6	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44186716	183522	0	None	194	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	524	7	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL482648	183522	0	None	194	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	524	7	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44583036	186362	0	None	7	5	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	10.1021/jm900413e
	CHEMBL490262	186362	0	None	7	5	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	10.1021/jm900413e
	CHEMBL521280	186362	0	None	7	5	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	10.1021/jm900413e
	57429647	158079	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	573	9	2	9	3.0	CCCn1c(=O)c2[nH]c(-c3cnn(CC(O)C4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4092455	158079	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	573	9	2	9	3.0	CCCn1c(=O)c2[nH]c(-c3cnn(CC(O)C4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	10875138	137849	0	None	19	4	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	532	9	2	8	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5OC)CC4)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL37726	137849	0	None	19	4	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	532	9	2	8	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5OC)CC4)cc3)nc2c1=O	10.1021/jm011049y
	10452788	161729	0	None	28	5	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	387	8	4	7	-0.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL416417	161729	0	None	28	5	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	387	8	4	7	-0.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)nc2c1=O	10.1021/jm011049y
	155556884	173997	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	542	7	2	8	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)c(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4556744	173997	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	542	7	2	8	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)c(F)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44186623	191481	0	None	31	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	512	6	2	7	1.7	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL520297	191481	0	None	31	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	512	6	2	7	1.7	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	155512438	169067	0	None	102	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	538	8	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4437222	169067	0	None	102	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	538	8	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(OC)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	57429619	157579	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	442	4	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(C(F)(F)F)cc4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4087158	157579	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	442	4	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(C(F)(F)F)cc4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	10075248	140702	0	None	28	5	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	516	9	2	7	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL38304	140702	0	None	28	5	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	516	9	2	7	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)nc2c1=O	10.1021/jm011049y
	145977111	163202	0	None	-7	4	Mouse	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	617	9	3	7	3.9	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4205635	163202	0	None	-7	4	Mouse	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	617	9	3	7	3.9	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	11605883	79527	5	None	42	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL212625	79527	5	None	42	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	76325369	105024	0	None	-4	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	385	5	1	8	0.3	Cn1c(=O)c2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	CHEMBL3121723	105024	0	None	-4	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	385	5	1	8	0.3	Cn1c(=O)c2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	46229140	197954	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	517	10	1	9	3.6	CCCn1c(=O)c2c(nc(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)n2C)n(CCC)c1=O	10.1016/j.bmc.2010.02.014
	CHEMBL592891	197954	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	517	10	1	9	3.6	CCCn1c(=O)c2c(nc(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)n2C)n(CCC)c1=O	10.1016/j.bmc.2010.02.014
	44236600	157690	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	484	6	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(F)(F)F)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4088514	157690	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	484	6	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(F)(F)F)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	57429649	158384	0	None	23	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	572	8	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4095843	158384	0	None	23	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	572	8	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44451075	95617	0	None	75	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	563	9	1	7	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260051	95617	0	None	75	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	563	9	1	7	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	9825550	57273	0	None	2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	461	9	2	7	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL16677	57273	0	None	2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	461	9	2	7	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	44451075	95617	0	None	75	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	563	9	1	7	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260051	95617	0	None	75	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	563	9	1	7	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	11684701	132901	0	None	17	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	496	5	2	6	3.4	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)Nc1ccc(Br)cc1	10.1021/jm0506221
	CHEMBL370588	132901	0	None	17	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	496	5	2	6	3.4	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)Nc1ccc(Br)cc1	10.1021/jm0506221
	44186670	191694	0	None	24	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	508	6	2	7	1.9	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL520617	191694	0	None	24	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	508	6	2	7	1.9	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	57429620	155256	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	458	5	2	7	2.6	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(OC(F)(F)F)cc4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4059779	155256	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	458	5	2	7	2.6	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(OC(F)(F)F)cc4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	57429617	156912	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	392	4	2	6	1.9	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(F)cc4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4079273	156912	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	392	4	2	6	1.9	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(F)cc4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	155536745	171627	0	None	208	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	467	8	2	6	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N(C)CCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4473749	171627	0	None	208	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	467	8	2	6	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N(C)CCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44574251	177844	0	None	12	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	451	8	2	8	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccon4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL466035	177844	0	None	12	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	451	8	2	8	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccon4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	44236445	156986	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	556	8	1	9	2.7	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(F)c(Cl)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4080171	156986	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	556	8	1	9	2.7	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(F)c(Cl)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44451329	95723	0	None	204	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	5	1	7	2.7	Cc1ccc(N2CCN(C(=O)C(C)Oc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1	10.1016/j.bmc.2008.01.002
	CHEMBL260692	95723	0	None	204	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	5	1	7	2.7	Cc1ccc(N2CCN(C(=O)C(C)Oc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1	10.1016/j.bmc.2008.01.002
	145977111	163202	0	None	-10	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	617	9	3	7	3.9	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4205635	163202	0	None	-10	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	617	9	3	7	3.9	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385/[125I]IABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [3H]ZM241385/[125I]IABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.7b00138
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385/[125I]IABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [3H]ZM241385/[125I]IABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.7b00138
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385/[125I]IABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [3H]ZM241385/[125I]IABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.7b00138
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385/[125I]IABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [3H]ZM241385/[125I]IABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.7b00138
	44276476	167520	0	None	13	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	475	9	2	7	3.7	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL432664	167520	0	None	13	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	475	9	2	7	3.7	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	155528717	170772	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	546	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5F)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4461478	170772	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	546	6	2	7	2.8	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5F)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155548264	173186	0	None	4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	542	6	1	8	2.7	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)nc2n(C)c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4537196	173186	0	None	4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	542	6	1	8	2.7	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)nc2n(C)c1=O	10.1021/acs.jmedchem.9b00071
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.0c01431
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.0c01431
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.0c01431
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.0c01431
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	76310832	105025	0	None	-9	4	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	369	5	1	7	1.1	Cn1c(=O)c2[nH]c(-c3ccc(OCCN4CCCC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	CHEMBL3121724	105025	0	None	-9	4	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	369	5	1	7	1.1	Cn1c(=O)c2[nH]c(-c3ccc(OCCN4CCCC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human Adenosine A2B receptorBinding affinity towards human Adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm011049y
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human Adenosine A2B receptorBinding affinity towards human Adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm011049y
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human Adenosine A2B receptorBinding affinity towards human Adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm011049y
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human Adenosine A2B receptorBinding affinity towards human Adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm011049y
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]IABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]IABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.5b01586
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]IABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]IABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.5b01586
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]IABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]IABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.5b01586
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]IABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]IABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.5b01586
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385/[125I]IABOPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 3 hrsDisplacement of [3H]ZM241385/[125I]IABOPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385/[125I]IABOPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 3 hrsDisplacement of [3H]ZM241385/[125I]IABOPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385/[125I]IABOPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 3 hrsDisplacement of [3H]ZM241385/[125I]IABOPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385/[125I]IABOPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 3 hrsDisplacement of [3H]ZM241385/[125I]IABOPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 3 hrs	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	44185874	185068	0	None	20	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	524	7	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486481	185068	0	None	20	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	524	7	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm0506221
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm0506221
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm0506221
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm0506221
	135522368	489	1	None	117	2	Human	8.0	pKi	=	8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	383	489	1	None	117	2	Human	8.0	pKi	=	8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	CHEMBL33491	489	1	None	117	2	Human	8.0	pKi	=	8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	135522368	489	1	None	117	2	Human	8.0	pKi	=	8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	383	489	1	None	117	2	Human	8.0	pKi	=	8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	CHEMBL33491	489	1	None	117	2	Human	8.0	pKi	=	8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	10.1021/jm0309654
	16072023	57691	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	308	4	1	5	3.4	CC(C)C(=O)Nc1cnc(-c2ccncc2)c(-c2ccco2)n1	10.1021/ml100249e
	CHEMBL1672614	57691	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	308	4	1	5	3.4	CC(C)C(=O)Nc1cnc(-c2ccncc2)c(-c2ccco2)n1	10.1021/ml100249e
	44574166	178118	0	None	1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	410	4	2	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4cccs4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL468295	178118	0	None	1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	410	4	2	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4cccs4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	136042341	70808	0	None	17	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	517	8	2	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(F)(F)F)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955917	70808	0	None	17	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	517	8	2	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(F)(F)F)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	49797794	10473	0	None	5	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	394	5	1	6	3.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C#N)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1169934	10473	0	None	5	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	394	5	1	6	3.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C#N)cc3)sc12	10.1016/j.bmcl.2010.05.056
	9901196	188236	0	None	-2	4	Human	8.0	pKi	=	8	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	308	3	2	8	1.8	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(O)c3)c2n1	10.1021/jm800961g
	CHEMBL506511	188236	0	None	-2	4	Human	8.0	pKi	=	8	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	308	3	2	8	1.8	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(O)c3)c2n1	10.1021/jm800961g
	11760836	99742	0	None	2	3	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]ZM-241380 binding to adenosine A2b receptorInhibition of [3H]ZM-241380 binding to adenosine A2b receptor	ChEMBL	386	8	4	7	-0.1	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)NCCN)cc3)nc2c1=O	10.1021/jm049513x
	CHEMBL288459	99742	0	None	2	3	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]ZM-241380 binding to adenosine A2b receptorInhibition of [3H]ZM-241380 binding to adenosine A2b receptor	ChEMBL	386	8	4	7	-0.1	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)NCCN)cc3)nc2c1=O	10.1021/jm049513x
	11760836	99742	0	None	2	3	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	386	8	4	7	-0.1	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)NCCN)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL288459	99742	0	None	2	3	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	386	8	4	7	-0.1	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)NCCN)cc3)nc2c1=O	10.1021/jm011049y
	2748282	103364	8	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091713	103364	8	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	2748282	103364	8	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=S)N1	10.1021/ml400185v
	CHEMBL3091713	103364	8	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=S)N1	10.1021/ml400185v
	136042354	70795	0	None	72	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	476	8	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955903	70795	0	None	72	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	476	8	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	9904456	98678	0	None	-8	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	301	2	1	9	1.6	CSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL281129	98678	0	None	-8	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	301	2	1	9	1.6	CSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	449	2595	44	None	-1	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2012.05.033
	453	2595	44	None	-1	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2012.05.033
	6603931	2595	44	None	-1	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2012.05.033
	CHEMBL273807	2595	44	None	-1	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2012.05.033
	44451229	154646	0	None	77	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	620	9	1	9	5.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL402474	154646	0	None	77	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	620	9	1	9	5.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	69030712	157406	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	489	8	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(C)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4084760	157406	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	489	8	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(C)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44236419	158598	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	540	8	1	9	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(F)cc5F)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4098199	158598	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	540	8	1	9	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(F)cc5F)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	11584027	139015	0	None	10	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	491	10	2	8	3.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC)nc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL379688	139015	0	None	10	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	491	10	2	8	3.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC)nc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	10981207	132989	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	358	7	3	6	1.3	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL37082	132989	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	358	7	3	6	1.3	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	11656570	73048	0	None	8	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	522	11	2	10	2.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4cc(OC)nc(OC)n4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201594	73048	0	None	8	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	522	11	2	10	2.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4cc(OC)nc(OC)n4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11632785	73174	0	None	13	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	404	5	2	6	2.3	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL201721	73174	0	None	13	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	404	5	2	6	2.3	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44451254	156335	9	None	912	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	592	5	1	9	4.0	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL407204	156335	9	None	912	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	592	5	1	9	4.0	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	135529371	108685	0	None	8	2	Human	7.0	pKi	=	7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	479	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OC)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32150	108685	0	None	8	2	Human	7.0	pKi	=	7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	479	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OC)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	11505071	72224	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	566	10	3	11	1.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)c4c(NC(=O)O)n(C)c(=O)n(C)c4=O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199280	72224	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	566	10	3	11	1.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)c4c(NC(=O)O)n(C)c(=O)n(C)c4=O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	9844693	81781	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	414	7	2	6	2.9	CCCn1c(=O)c2nc([C@]34CC[C@](/C=C/C(=O)O)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	CHEMBL217076	81781	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	414	7	2	6	2.9	CCCn1c(=O)c2nc([C@]34CC[C@](/C=C/C(=O)O)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	137649458	156593	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	438	6	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CC4(O)CCCCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4075201	156593	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	438	6	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CC4(O)CCCCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	44451165	158243	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	531	9	1	9	2.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cnccn5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL409440	158243	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	531	9	1	9	2.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cnccn5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	46837563	10475	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	436	7	3	5	3.3	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	CHEMBL1169969	10475	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	436	7	3	5	3.3	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	44406567	72334	0	None	6	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccccc5C(F)(F)F)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL199692	72334	0	None	6	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccccc5C(F)(F)F)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11618633	77755	0	None	-1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	420	9	1	7	3.2	CCCn1c(=O)c2nc(-c3cnn(CCCc4ccccc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210319	77755	0	None	-1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	420	9	1	7	3.2	CCCn1c(=O)c2nc(-c3cnn(CCCc4ccccc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	10193	2949	30	None	-46	4	Human	6.0	pKi	=	6	Binding	Antagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assayAntagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assay	ChEMBL	305	2	1	7	1.2	Nc1nc(nc(c1Br)n1cccn1)n1cccn1	10.1021/acs.jmedchem.0c00237
	53466958	2949	30	None	-46	4	Human	6.0	pKi	=	6	Binding	Antagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assayAntagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assay	ChEMBL	305	2	1	7	1.2	Nc1nc(nc(c1Br)n1cccn1)n1cccn1	10.1021/acs.jmedchem.0c00237
	CHEMBL3638684	2949	30	None	-46	4	Human	6.0	pKi	=	6	Binding	Antagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assayAntagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assay	ChEMBL	305	2	1	7	1.2	Nc1nc(nc(c1Br)n1cccn1)n1cccn1	10.1021/acs.jmedchem.0c00237
	CHEMBL3694769	2949	30	None	-46	4	Human	6.0	pKi	=	6	Binding	Antagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assayAntagonist activity at human adenosine A2b receptor expressed in HEK293 cells by radioligand competition binding assay	ChEMBL	305	2	1	7	1.2	Nc1nc(nc(c1Br)n1cccn1)n1cccn1	10.1021/acs.jmedchem.0c00237
	155521637	170090	0	None	-25	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assayDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assay	ChEMBL	313	2	1	4	3.7	Clc1cccc(-c2nc(N3CCCCC3)c3nc[nH]c3n2)c1	10.1016/j.bmc.2019.06.034
	CHEMBL4451553	170090	0	None	-25	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assayDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assay	ChEMBL	313	2	1	4	3.7	Clc1cccc(-c2nc(N3CCCCC3)c3nc[nH]c3n2)c1	10.1016/j.bmc.2019.06.034
	70686119	75081	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	338	5	3	5	2.4	COc1cccc2cc(C(=O)NCC(O)c3ccccc3)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	CHEMBL2042072	75081	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	338	5	3	5	2.4	COc1cccc2cc(C(=O)NCC(O)c3ccccc3)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	6032251	75089	3	None	-3	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	233	3	1	5	1.5	COC(=O)/C(C#N)=C/c1cccc(OC)c1O	10.1016/j.ejmech.2012.05.009
	CHEMBL2042091	75089	3	None	-3	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	233	3	1	5	1.5	COC(=O)/C(C#N)=C/c1cccc(OC)c1O	10.1016/j.ejmech.2012.05.009
	2989630	103544	13	None	-67	5	Human	5.0	pKi	=	5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	329	1	0	7	1.1	Cn1c(=O)c2c(nc3n2CCCN3c2ccc(F)cc2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL3093328	103544	13	None	-67	5	Human	5.0	pKi	=	5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	329	1	0	7	1.1	Cn1c(=O)c2c(nc3n2CCCN3c2ccc(F)cc2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	137632333	155978	0	None	-1348	4	Human	5.0	pKi	=	5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	445	6	1	7	4.1	COc1ccc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3ccc(F)cc3)nc12	10.1021/acs.jmedchem.6b01584
	CHEMBL4068032	155978	0	None	-1348	4	Human	5.0	pKi	=	5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	445	6	1	7	4.1	COc1ccc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3ccc(F)cc3)nc12	10.1021/acs.jmedchem.6b01584
	70688247	75077	0	None	-25	2	Human	5.0	pKi	=	5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	476	8	4	8	2.7	COc1cccc2cc(C(=O)NCCCNC(=O)c3cc4cccc(OC)c4oc3=N)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	CHEMBL2042060	75077	0	None	-25	2	Human	5.0	pKi	=	5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	476	8	4	8	2.7	COc1cccc2cc(C(=O)NCCCNC(=O)c3cc4cccc(OC)c4oc3=N)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	70683991	75078	0	None	-31	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	602	12	4	10	2.7	COc1cccc2cc(C(=O)NCCCN3CCN(CCCNC(=O)c4cc5cccc(OC)c5oc4=N)CC3)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	CHEMBL2042061	75078	0	None	-31	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	602	12	4	10	2.7	COc1cccc2cc(C(=O)NCCCN3CCN(CCCNC(=O)c4cc5cccc(OC)c5oc4=N)CC3)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	2989630	103544	13	None	-67	5	Human	5.0	pKi	=	5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	329	1	0	7	1.1	Cn1c(=O)c2c(nc3n2CCCN3c2ccc(F)cc2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL3093328	103544	13	None	-67	5	Human	5.0	pKi	=	5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	329	1	0	7	1.1	Cn1c(=O)c2c(nc3n2CCCN3c2ccc(F)cc2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	11081	3156	1	None	-30	6	Human	5.0	pKi	=	5	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1016/j.bmc.2007.07.051
	44437220	3156	1	None	-30	6	Human	5.0	pKi	=	5	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1016/j.bmc.2007.07.051
	CHEMBL239232	3156	1	None	-30	6	Human	5.0	pKi	=	5	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	10.1016/j.bmc.2007.07.051
	3162488	90699	10	None	-31	5	Human	5.0	pKi	=	5	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	339	3	0	7	0.9	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2)n(C)c1=O	10.1016/j.bmc.2007.07.051
	CHEMBL239864	90699	10	None	-31	5	Human	5.0	pKi	=	5	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	339	3	0	7	0.9	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2)n(C)c1=O	10.1016/j.bmc.2007.07.051
	11003653	145293	0	None	-2	4	Human	5.0	pKi	=	5	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	389	4	0	8	1.4	Cn1c(=O)c2c(nc3n2CCCN3CCOc2ccc(Cl)cc2)n(C)c1=O	10.1016/j.bmc.2007.07.051
	CHEMBL391718	145293	0	None	-2	4	Human	5.0	pKi	=	5	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	389	4	0	8	1.4	Cn1c(=O)c2c(nc3n2CCCN3CCOc2ccc(Cl)cc2)n(C)c1=O	10.1016/j.bmc.2007.07.051
	2519	765	83	None	-9	12	Human	5.0	pKi	=	5	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2018.11.045
	407	765	83	None	-9	12	Human	5.0	pKi	=	5	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2018.11.045
	463	765	83	None	-9	12	Human	5.0	pKi	=	5	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2018.11.045
	CHEMBL113	765	83	None	-9	12	Human	5.0	pKi	=	5	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2018.11.045
	DB00201	765	83	None	-9	12	Human	5.0	pKi	=	5	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2018.11.045
	3280	3987	40	None	-245	4	Human	5.0	pKi	=	5	Binding	Percent displacement of [3H]DPCPX binding in human adenosine A2B receptor expressed in COS-7 cellsPercent displacement of [3H]DPCPX binding in human adenosine A2B receptor expressed in COS-7 cells	ChEMBL	371	4	2	5	4.3	COc1ccccc1NC(=O)Nc1nc(nc2c1cccc2)c1cccnc1	10.1021/jm0003945
	4046493	3987	40	None	-245	4	Human	5.0	pKi	=	5	Binding	Percent displacement of [3H]DPCPX binding in human adenosine A2B receptor expressed in COS-7 cellsPercent displacement of [3H]DPCPX binding in human adenosine A2B receptor expressed in COS-7 cells	ChEMBL	371	4	2	5	4.3	COc1ccccc1NC(=O)Nc1nc(nc2c1cccc2)c1cccnc1	10.1021/jm0003945
	CHEMBL70880	3987	40	None	-245	4	Human	5.0	pKi	=	5	Binding	Percent displacement of [3H]DPCPX binding in human adenosine A2B receptor expressed in COS-7 cellsPercent displacement of [3H]DPCPX binding in human adenosine A2B receptor expressed in COS-7 cells	ChEMBL	371	4	2	5	4.3	COc1ccccc1NC(=O)Nc1nc(nc2c1cccc2)c1cccnc1	10.1021/jm0003945
	162677251	182945	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	3	3.0	CC1=C(C(=O)CC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4800076	182945	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	3	3.0	CC1=C(C(=O)CC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	162643106	181063	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	262	4	2	3	2.5	CC1=C(C(=O)CC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4776088	181063	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	262	4	2	3	2.5	CC1=C(C(=O)CC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	162673336	182553	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	290	3	2	4	2.4	CC1=C(C(=O)OC2CCCC2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4795209	182553	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	290	3	2	4	2.4	CC1=C(C(=O)OC2CCCC2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	11811761	56241	0	None	-8	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116	ChEMBL	415	7	1	8	3.7	CCCCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL163968	56241	0	None	-8	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116	ChEMBL	415	7	1	8	3.7	CCCCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	10927693	56442	0	None	-3	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116	ChEMBL	408	3	2	8	3.6	Cn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164281	56442	0	None	-3	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116	ChEMBL	408	3	2	8	3.6	Cn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11661440	79428	0	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	407	7	4	7	-0.1	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCC(=O)O)cc3)nc2c1=O	10.1021/jm060277v
	CHEMBL212217	79428	0	None	1	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	407	7	4	7	-0.1	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCC(=O)O)cc3)nc2c1=O	10.1021/jm060277v
	44390615	122101	0	None	-	1	Human	6.0	pKi	=	6	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(C(F)(F)F)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL360366	122101	0	None	-	1	Human	6.0	pKi	=	6	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(C(F)(F)F)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	136002185	167606	0	None	-	1	Human	6.0	pKi	=	6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	480	9	2	10	1.8	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C)cn4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL433235	167606	0	None	-	1	Human	6.0	pKi	=	6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	480	9	2	10	1.8	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C)cn4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	137640212	156412	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	274	3	2	5	1.2	CCOC(=O)C1=C(C)N/C(=N\C#N)NC1c1ccoc1	10.1021/acs.jmedchem.7b00138
	CHEMBL4072891	156412	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	274	3	2	5	1.2	CCOC(=O)C1=C(C)N/C(=N\C#N)NC1c1ccoc1	10.1021/acs.jmedchem.7b00138
	11567017	79528	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	377	4	2	7	0.3	CC(C)NS(=O)(=O)c1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1021/jm060277v
	CHEMBL212626	79528	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	377	4	2	7	0.3	CC(C)NS(=O)(=O)c1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1021/jm060277v
	11821203	201399	5	None	-6	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	256	2	1	5	0.5	Cn1c(=O)n(Cc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	CHEMBL63944	201399	5	None	-6	5	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	256	2	1	5	0.5	Cn1c(=O)n(Cc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	11821203	201399	5	None	-6	5	Rat	5.0	pKi	=	5.0	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	256	2	1	5	0.5	Cn1c(=O)n(Cc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	CHEMBL63944	201399	5	None	-6	5	Rat	5.0	pKi	=	5.0	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	256	2	1	5	0.5	Cn1c(=O)n(Cc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	9928335	119579	1	None	-28	6	Rat	6.0	pKi	=	6.0	Binding	In vivo binding affinity was evaluated against Alpha-2 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-2 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
	CHEMBL35093	119579	1	None	-28	6	Rat	6.0	pKi	=	6.0	Binding	In vivo binding affinity was evaluated against Alpha-2 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-2 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
	135493272	110956	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	465	8	3	9	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(O)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32757	110956	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	465	8	3	9	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(O)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135464144	112485	0	None	-5623	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 772-1390Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 772-1390	ChEMBL	322	5	1	6	3.0	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(OC)cc3)nn12	10.1021/jm010570p
	CHEMBL331111	112485	0	None	-5623	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 772-1390Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 772-1390	ChEMBL	322	5	1	6	3.0	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(OC)cc3)nn12	10.1021/jm010570p
	156017083	177095	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2ccno2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4641788	177095	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2ccno2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	2519	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	407	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	463	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	CHEMBL113	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	DB00201	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	2519	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	407	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	463	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	CHEMBL113	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	DB00201	765	83	None	-9	12	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	162668237	181913	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	306	4	2	4	2.7	CC1=C(C(=O)OCC2CCC2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4786993	181913	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	306	4	2	4	2.7	CC1=C(C(=O)OCC2CCC2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	46837564	10476	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	418	7	3	5	3.1	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	CHEMBL1169970	10476	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	418	7	3	5	3.1	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	52948915	19084	0	None	33	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	541	9	2	5	6.0	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccc(F)cc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290437	19084	0	None	33	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	541	9	2	5	6.0	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccc(F)cc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	44406556	133825	0	None	14	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(OC)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL371731	133825	0	None	14	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(OC)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	162663910	181465	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	246	3	2	3	1.9	CC1=C(C(=O)C2CC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4781313	181465	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	246	3	2	3	1.9	CC1=C(C(=O)C2CC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL5070276	212449	0	None	-16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(Nc2ccccc2)nc1-c1ccccc1F	10.1021/acs.jmedchem.1c01636
	10175278	169805	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	588	9	2	8	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)nc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL444787	169805	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	588	9	2	8	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)nc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10175278	169805	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	588	9	2	8	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)nc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL444787	169805	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	588	9	2	8	3.4	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)nc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	127034213	138584	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	273	3	1	6	2.3	CCOC(=O)C1=C(C)Nc2nccn2C1c1ccco1	10.1021/acs.jmedchem.5b01586
	CHEMBL3786936	138584	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	273	3	1	6	2.3	CCOC(=O)C1=C(C)Nc2nccn2C1c1ccco1	10.1021/acs.jmedchem.5b01586
	44520941	200336	0	None	-275	4	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	309	4	2	6	2.0	Cc1ccc(-c2cc(C(=O)NCc3ccccn3)nc(N)n2)o1	10.1016/j.bmc.2009.07.078
	CHEMBL608383	200336	0	None	-275	4	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	309	4	2	6	2.0	Cc1ccc(-c2cc(C(=O)NCc3ccccn3)nc(N)n2)o1	10.1016/j.bmc.2009.07.078
	127043828	140581	0	None	-1	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	538	15	0	9	4.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN(CC)CC)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	CHEMBL3827331	140581	0	None	-1	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	538	15	0	9	4.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN(CC)CC)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	9901260	189486	0	None	-40	4	Human	7.0	pKi	=	7.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	310	3	1	7	2.3	Nc1nc(-c2ccco2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	CHEMBL517278	189486	0	None	-40	4	Human	7.0	pKi	=	7.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	310	3	1	7	2.3	Nc1nc(-c2ccco2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	168297723	191844	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	327	4	2	6	2.2	CCCn1c(=O)[nH]c2nc(-c3cccc(N=C=S)c3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5208506	191844	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	327	4	2	6	2.2	CCCn1c(=O)[nH]c2nc(-c3cccc(N=C=S)c3)[nH]c2c1=O	10.1039/d2md00132b
	162664587	181469	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	292	3	2	4	2.5	CC1=C(C(=O)OC2CCC2)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4781342	181469	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	292	3	2	4	2.5	CC1=C(C(=O)OC2CCC2)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	44583035	172162	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	593	5	1	10	3.4	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)nc2n(C)c1=O	10.1021/jm900413e
	CHEMBL450826	172162	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	593	5	1	10	3.4	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)nc2n(C)c1=O	10.1021/jm900413e
	9821879	94530	5	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	392	7	1	7	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL254725	94530	5	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	392	7	1	7	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	21958593	154951	0	None	14	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	368	5	2	6	1.9	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL404131	154951	0	None	14	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	368	5	2	6	1.9	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	44451254	156335	9	None	912	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	592	5	1	9	4.0	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL407204	156335	9	None	912	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	592	5	1	9	4.0	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	11952559	6217	0	None	194	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	293	2	1	6	2.0	Cn1c(=O)[nH]c2nc(-c3ccco3)c(-c3ccncn3)cc21	10.1016/j.bmcl.2010.01.077
	CHEMBL1081841	6217	0	None	194	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	293	2	1	6	2.0	Cn1c(=O)[nH]c2nc(-c3ccco3)c(-c3ccncn3)cc21	10.1016/j.bmcl.2010.01.077
	16070335	57697	0	None	28	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	317	4	1	5	2.9	O=C(Nc1cnc(-c2ccncc2)c(-c2ccccn2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672620	57697	0	None	28	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	317	4	1	5	2.9	O=C(Nc1cnc(-c2ccncc2)c(-c2ccccn2)n1)C1CC1	10.1021/ml100249e
	16071897	57707	0	None	120	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2ccncc2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672630	57707	0	None	120	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2ccncc2)n1)C1CC1	10.1021/ml100249e
	44588471	174134	0	None	10	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	343	5	3	6	2.4	CCCn1c(=O)c2[nH]c(-c3ccc(O)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL455999	174134	0	None	10	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	343	5	3	6	2.4	CCCn1c(=O)c2[nH]c(-c3ccc(O)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	24827442	95304	0	None	22	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	460	6	1	7	3.5	CCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21	10.1021/jm7014815
	CHEMBL258499	95304	0	None	22	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	460	6	1	7	3.5	CCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21	10.1021/jm7014815
	22266778	95305	0	None	38	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL258507	95305	0	None	38	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	21916419	95516	0	None	8	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	376	5	1	7	1.7	Cn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc21	10.1021/jm7014815
	CHEMBL259524	95516	0	None	8	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	376	5	1	7	1.7	Cn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc21	10.1021/jm7014815
	9821879	94530	5	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	392	7	1	7	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL254725	94530	5	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	392	7	1	7	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(CCC)c1=O	10.1021/jm051268+
	876881	181814	2	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccsc1	10.1021/acs.jmedchem.0c01431
	CHEMBL4785606	181814	2	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccsc1	10.1021/acs.jmedchem.0c01431
	11677724	140146	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	499	10	2	7	4.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC#N)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL381540	140146	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	499	10	2	7	4.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC#N)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44450930	95359	0	None	26	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	518	6	1	7	2.9	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(C(=O)c5ccc(F)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL258810	95359	0	None	26	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	518	6	1	7	2.9	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(C(=O)c5ccc(F)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	155527939	170685	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CC1=C(C(=O)OCC(F)(F)F)[C@@H](c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4460214	170685	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CC1=C(C(=O)OCC(F)(F)F)[C@@H](c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	127031266	138523	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	1	6	3.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL3786336	138523	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	1	6	3.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	127031266	138523	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	3	1	6	3.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3786336	138523	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	3	1	6	3.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.5b01586
	127031266	138523	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	3	1	6	3.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL3786336	138523	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	3	1	6	3.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	136042346	70815	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	461	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955924	70815	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	461	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	44574191	188811	0	None	11	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	473	4	1	7	2.7	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL513135	188811	0	None	11	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	473	4	1	7	2.7	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	145971798	163930	0	None	14	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	631	10	3	7	4.3	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4214450	163930	0	None	14	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	631	10	3	7	4.3	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	44185873	191879	0	None	31	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	510	6	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL520899	191879	0	None	31	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	510	6	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	45268867	194498	0	None	12	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	519	11	2	9	2.8	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL561364	194498	0	None	12	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	519	11	2	9	2.8	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11519021	140811	0	None	223	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	504	9	2	8	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)OCC)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL383638	140811	0	None	223	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	504	9	2	8	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)OCC)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44451073	157016	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	553	9	1	7	3.7	O=C(COc1ccc(-c2cc3c([nH]2)c(=O)n(CC2CC2)c(=O)n3CC2CC2)cc1)N1CCN(c2ccccc2)CC1	10.1016/j.bmc.2008.01.002
	CHEMBL408048	157016	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	553	9	1	7	3.7	O=C(COc1ccc(-c2cc3c([nH]2)c(=O)n(CC2CC2)c(=O)n3CC2CC2)cc1)N1CCN(c2ccccc2)CC1	10.1016/j.bmc.2008.01.002
	168297138	191633	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	368	5	2	7	1.1	CCCn1c(=O)[nH]c2nc(-c3ccc(OS(=O)(=O)F)cc3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5205220	191633	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	368	5	2	7	1.1	CCCn1c(=O)[nH]c2nc(-c3ccc(OS(=O)(=O)F)cc3)[nH]c2c1=O	10.1039/d2md00132b
	11781054	204685	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	284	4	2	4	1.9	CCCCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm0310030
	CHEMBL8789	204685	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	284	4	2	4	1.9	CCCCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm0310030
	11781054	204685	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	284	4	2	4	1.9	CCCCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm011049y
	CHEMBL8789	204685	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	284	4	2	4	1.9	CCCCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm011049y
	44281700	110940	0	None	12	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	480	7	3	6	4.7	CCCn1c(=O)c2nc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32751	110940	0	None	12	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	480	7	3	6	4.7	CCCn1c(=O)c2nc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	137631671	155780	0	None	-53	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	352	5	1	5	3.9	CCCn1c(-c2cccc(OC)c2)nc2nc(C3CCCC3)[nH]c2c1=O	10.1016/j.bmc.2017.02.029
	CHEMBL4065762	155780	0	None	-53	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	352	5	1	5	3.9	CCCn1c(-c2cccc(OC)c2)nc2nc(C3CCCC3)[nH]c2c1=O	10.1016/j.bmc.2017.02.029
	127043828	140581	0	None	-13	7	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant rat adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	538	15	0	9	4.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN(CC)CC)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	CHEMBL3827331	140581	0	None	-13	7	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant rat adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	538	15	0	9	4.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN(CC)CC)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	135424850	77870	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	378	6	1	7	2.6	CCCn1c(=O)c2nc(-c3ccnn3-c3ccccc3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210738	77870	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	378	6	1	7	2.6	CCCn1c(=O)c2nc(-c3ccnn3-c3ccccc3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	2895908	44022	14	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	282	3	2	5	2.5	CCOC(=O)C1=C(C)N=C(S)NC1c1ccsc1	10.1021/acs.jmedchem.0c01431
	CHEMBL1517366	44022	14	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	282	3	2	5	2.5	CCOC(=O)C1=C(C)N=C(S)NC1c1ccsc1	10.1021/acs.jmedchem.0c01431
	2895908	44022	14	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	282	3	2	5	2.5	CCOC(=O)C1=C(C)N=C(S)NC1c1ccsc1	10.1021/ml400185v
	CHEMBL1517366	44022	14	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	282	3	2	5	2.5	CCOC(=O)C1=C(C)N=C(S)NC1c1ccsc1	10.1021/ml400185v
	156014646	176649	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	2	6	3.0	CC1=C(C(=O)OC(C)C)C(c2cc[nH]n2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4635701	176649	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	2	6	3.0	CC1=C(C(=O)OC(C)C)C(c2cc[nH]n2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	135529398	117762	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	600	12	2	11	3.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5ccc([N+](=O)[O-])cc5)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL34097	117762	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	600	12	2	11	3.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5ccc([N+](=O)[O-])cc5)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	22266763	72463	0	None	20	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	493	8	1	9	3.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccccc5Cl)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200154	72463	0	None	20	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	493	8	1	9	3.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccccc5Cl)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	169317	1173	30	None	-44	9	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	427	1173	30	None	-44	9	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	CHEMBL157655	1173	30	None	-44	9	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	176408	3488	79	None	-407	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00237
	403	3488	79	None	-407	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00237
	431	3488	79	None	-407	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00237
	CHEMBL17127	3488	79	None	-407	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00237
	176408	3488	79	None	-407	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/jm4011669
	403	3488	79	None	-407	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/jm4011669
	431	3488	79	None	-407	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/jm4011669
	CHEMBL17127	3488	79	None	-407	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/jm4011669
	13525063	9280	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	300	2	2	6	0.3	Cn1c(=O)c2nc(-c3ccccc3C(=O)O)[nH]c2n(C)c1=O	10.1021/jm0104318
	CHEMBL11146	9280	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	300	2	2	6	0.3	Cn1c(=O)c2nc(-c3ccccc3C(=O)O)[nH]c2n(C)c1=O	10.1021/jm0104318
	10769581	36514	0	None	-4	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 934-1327Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 934-1327	ChEMBL	579	4	1	8	4.8	Nc1nc2nn(CCc3cc(Br)c(Br)cc3Br)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL144972	36514	0	None	-4	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 934-1327Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 934-1327	ChEMBL	579	4	1	8	4.8	Nc1nc2nn(CCc3cc(Br)c(Br)cc3Br)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	9949541	95832	0	None	-107	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	334	3	2	7	2.4	Nc1nc(-c2ccco2)c2ncn(C(=O)NCc3ccccc3)c2n1	10.1021/jm4011669
	CHEMBL261203	95832	0	None	-107	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	334	3	2	7	2.4	Nc1nc(-c2ccco2)c2ncn(C(=O)NCc3ccccc3)c2n1	10.1021/jm4011669
	44390522	64131	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccccc5C)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL181400	64131	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccccc5C)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	52950027	18936	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	478	9	2	4	5.3	O=C(COc1ccc2[nH]c(=O)c(-c3ccco3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289461	18936	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	478	9	2	4	5.3	O=C(COc1ccc2[nH]c(=O)c(-c3ccco3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	162677300	182946	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	275	2	2	4	2.8	CC1=C(c2ncc(C)o2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4800081	182946	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	275	2	2	4	2.8	CC1=C(c2ncc(C)o2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	145981370	166167	0	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	595	17	1	10	3.3	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN(CC)CC)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	CHEMBL4283160	166167	0	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	595	17	1	10	3.3	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN(CC)CC)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	52941597	18886	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	357	5	1	4	2.7	COc1ccc2[nH]c(=O)c(S(C)(=O)=O)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289109	18886	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	357	5	1	4	2.7	COc1ccc2[nH]c(=O)c(S(C)(=O)=O)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	21874634	189485	0	None	-9	4	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	294	3	1	9	0.9	Nc1nc(-c2ccco2)c2nnn(Cc3cnccn3)c2n1	10.1021/jm800961g
	CHEMBL517277	189485	0	None	-9	4	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	294	3	1	9	0.9	Nc1nc(-c2ccco2)c2nnn(Cc3cnccn3)c2n1	10.1021/jm800961g
	CHEMBL5087059	213285	0	None	-3	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL		None	None	None		Nc1nc(-c2ccccc2)c2c(n1)-c1ccc(OCCCN3CCCCC3)cc1C2=O	10.1021/acs.jmedchem.0c00914
	46837702	10477	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	487	7	2	6	2.8	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	CHEMBL1169971	10477	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	487	7	2	6	2.8	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	5053422	201849	37	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	296	3	0	6	1.3	C=CCn1c(=O)c2c(nc(-c3ccccc3)n2C)n(C)c1=O	10.1021/jm0104318
	CHEMBL66610	201849	37	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	296	3	0	6	1.3	C=CCn1c(=O)c2c(nc(-c3ccccc3)n2C)n(C)c1=O	10.1021/jm0104318
	11638790	141937	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	346	5	1	8	3.3	COc1ccc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)cn1	10.1021/jm061333v
	CHEMBL389040	141937	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	346	5	1	8	3.3	COc1ccc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)cn1	10.1021/jm061333v
	44588470	174132	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	343	5	2	7	2.4	CCCn1c(=O)c2c(cc(-c3ccc(O)cc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL455998	174132	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	343	5	2	7	2.4	CCCn1c(=O)c2c(cc(-c3ccc(O)cc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	76309933	103366	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	3	1	4	2.2	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1C	10.1021/acs.jmedchem.0c01431
	CHEMBL3091715	103366	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	3	1	4	2.2	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1C	10.1021/acs.jmedchem.0c01431
	76309933	103366	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	278	3	1	4	2.2	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1C	10.1021/ml400185v
	CHEMBL3091715	103366	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	278	3	1	4	2.2	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1C	10.1021/ml400185v
	9955052	119365	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 91-148Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 91-148	ChEMBL	442	3	2	8	4.2	Cn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL349019	119365	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 91-148Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 91-148	ChEMBL	442	3	2	8	4.2	Cn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11565927	84932	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	317	4	1	8	2.7	c1coc(-c2nc(Nc3cnccn3)ncc2-c2ccncn2)c1	10.1021/jm061333v
	CHEMBL226188	84932	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	317	4	1	8	2.7	c1coc(-c2nc(Nc3cnccn3)ncc2-c2ccncn2)c1	10.1021/jm061333v
	46228011	198483	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	364	6	1	6	2.5	CCCn1c(=O)c2[nH]c(Cc3ccccc3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL596558	198483	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	364	6	1	6	2.5	CCCn1c(=O)c2[nH]c(Cc3ccccc3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	155548797	173155	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	393	3	1	6	4.5	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccsc1	10.1021/acs.jmedchem.9b01340
	CHEMBL4536469	173155	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	393	3	1	6	4.5	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccsc1	10.1021/acs.jmedchem.9b01340
	21874756	190191	0	None	-117	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	335	4	2	8	2.3	CCc1cc(Cn2nnc3c(-c4ccco4)nc(N)nc32)ccc1N	10.1021/jm800961g
	CHEMBL518364	190191	0	None	-117	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	335	4	2	8	2.3	CCc1cc(Cn2nnc3c(-c4ccco4)nc(N)nc32)ccc1N	10.1021/jm800961g
	10436433	130838	0	None	-30	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	512	9	5	15	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL368880	130838	0	None	-30	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	512	9	5	15	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	44410554	140327	0	None	-346	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	511	7	5	12	0.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4cccc([N+](=O)[O-])c4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL381972	140327	0	None	-346	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	511	7	5	12	0.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4cccc([N+](=O)[O-])c4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	3481963	37839	7	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	294	4	2	4	2.6	CC1=C(C(=O)OCC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL1460793	37839	7	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	294	4	2	4	2.6	CC1=C(C(=O)OCC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	16720104	84824	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	386	6	1	8	3.5	O=c1ccc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)cn1CC1CC1	10.1021/jm061333v
	CHEMBL225982	84824	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	386	6	1	8	3.5	O=c1ccc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)cn1CC1CC1	10.1021/jm061333v
	71680890	89770	0	None	-2	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	322	4	1	4	3.7	O=C(C/C=C/c1ccccc1)Nc1nc2ccccc2c(=O)s1	10.1021/jm400336x
	CHEMBL2382438	89770	0	None	-2	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	322	4	1	4	3.7	O=C(C/C=C/c1ccccc1)Nc1nc2ccccc2c(=O)s1	10.1021/jm400336x
	162669248	182017	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	4	2	4	1.9	CCCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	CHEMBL4788318	182017	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	4	2	4	1.9	CCCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	135443367	484	0	None	22	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	382	484	0	None	22	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	CHEMBL33455	484	0	None	22	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	135493279	99904	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL289903	99904	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135522375	113745	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	525	11	2	11	2.1	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)c(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33305	113745	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	525	11	2	11	2.1	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)c(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135443367	484	0	None	22	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	382	484	0	None	22	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	CHEMBL33455	484	0	None	22	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	135493279	99904	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL289903	99904	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135522375	113745	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	525	11	2	11	2.1	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)c(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33305	113745	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	525	11	2	11	2.1	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)c(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10926253	80631	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	353	2	1	10	0.6	CN1CCN(c2c3c(nc(N)n4nc(-c5ccco5)nc34)nn2C)CC1	10.1021/jm021023m
	CHEMBL21541	80631	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	353	2	1	10	0.6	CN1CCN(c2c3c(nc(N)n4nc(-c5ccco5)nc34)nn2C)CC1	10.1021/jm021023m
	CHEMBL553587	80631	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	353	2	1	10	0.6	CN1CCN(c2c3c(nc(N)n4nc(-c5ccco5)nc34)nn2C)CC1	10.1021/jm021023m
	10852375	37303	0	None	-15	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 8-18Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 8-18	ChEMBL	309	3	1	8	2.3	CC(C)=CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL145623	37303	0	None	-15	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 8-18Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 8-18	ChEMBL	309	3	1	8	2.3	CC(C)=CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	44236850	155601	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	582	8	1	9	3.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4063759	155601	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	582	8	1	9	3.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	57429608	156112	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	470	5	1	7	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(F)(F)F)cc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4069518	156112	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	470	5	1	7	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(F)(F)F)cc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	44236506	158881	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	474	7	1	9	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccccc4C(=O)OC)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4101147	158881	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	474	7	1	9	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccccc4C(=O)OC)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	66892867	155766	0	None	27	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	479	7	1	8	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4065629	155766	0	None	27	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	479	7	1	8	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	66892710	156982	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	475	8	1	8	3.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(C)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4080098	156982	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	475	8	1	8	3.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(C)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	22266742	94118	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	431	6	2	8	2.6	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4cc(-c5ccccc5)on4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251880	94118	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	431	6	2	8	2.6	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4cc(-c5ccccc5)on4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	16072024	57695	0	None	8	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	348	5	1	5	4.3	O=C(CC1CCCC1)Nc1cnc(-c2ccncc2)c(-c2ccco2)n1	10.1021/ml100249e
	CHEMBL1672618	57695	0	None	8	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	348	5	1	5	4.3	O=C(CC1CCCC1)Nc1cnc(-c2ccncc2)c(-c2ccco2)n1	10.1021/ml100249e
	50940964	56967	0	None	-3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	269	3	1	5	3.0	CC(=O)Nc1cc(-c2ccco2)nc(-c2ccco2)n1	10.1021/jm100843z
	CHEMBL1650384	56967	0	None	-3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	269	3	1	5	3.0	CC(=O)Nc1cc(-c2ccco2)nc(-c2ccco2)n1	10.1021/jm100843z
	136042329	70796	0	None	41	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	534	10	2	11	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(=O)OCC)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955904	70796	0	None	41	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	534	10	2	11	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(=O)OCC)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	135493279	99904	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL289903	99904	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm201292w
	135874420	160743	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	9	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(OC)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL412284	160743	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	9	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(OC)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	52946453	19012	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	521	9	2	5	5.6	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NC1(c2ccccc2)CC1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290001	19012	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	521	9	2	5	5.6	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NC1(c2ccccc2)CC1	10.1016/j.bmcl.2010.10.030
	11720113	73869	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	490	10	2	7	4.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL202358	73869	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	490	10	2	7	4.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	3909843	138430	14	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccco1	10.1021/acs.jmedchem.0c00564
	CHEMBL3785290	138430	14	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccco1	10.1021/acs.jmedchem.0c00564
	3909843	138430	14	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccco1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785290	138430	14	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccco1	10.1021/acs.jmedchem.5b01586
	3909843	138430	14	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccco1	10.1021/acs.jmedchem.9b01340
	CHEMBL3785290	138430	14	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccco1	10.1021/acs.jmedchem.9b01340
	155545585	172874	0	None	19	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	568	10	3	9	1.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OCCO)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4529435	172874	0	None	19	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	568	10	3	9	1.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OCCO)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	11561073	74392	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	7	2	6	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL203088	74392	0	None	13	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	7	2	6	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11693081	137886	0	None	34	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	637	14	3	8	5.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)NCCc5ccc(OC)cc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL377434	137886	0	None	34	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	637	14	3	8	5.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)NCCc5ccc(OC)cc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44450931	95578	0	None	64	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	472	5	1	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259869	95578	0	None	64	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	472	5	1	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	11525776	73049	0	None	21	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	475	9	2	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C)cn4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201595	73049	0	None	21	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	475	9	2	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C)cn4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11548559	73874	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	556	9	2	6	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)c(Br)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL202359	73874	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	556	9	2	6	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)c(Br)c2n(CCC)c1=O	10.1021/jm0506221
	449	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat A2B adenosine receptor by radio-ligand displacement assayBinding affinity to rat A2B adenosine receptor by radio-ligand displacement assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	453	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat A2B adenosine receptor by radio-ligand displacement assayBinding affinity to rat A2B adenosine receptor by radio-ligand displacement assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	6603931	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat A2B adenosine receptor by radio-ligand displacement assayBinding affinity to rat A2B adenosine receptor by radio-ligand displacement assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	CHEMBL273807	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat A2B adenosine receptor by radio-ligand displacement assayBinding affinity to rat A2B adenosine receptor by radio-ligand displacement assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	449	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	453	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	6603931	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	CHEMBL273807	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	136414902	159155	0	None	34	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	560	9	1	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4104450	159155	0	None	34	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	560	9	1	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	449	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm0104318
	453	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm0104318
	6603931	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm0104318
	CHEMBL273807	2595	44	None	-9	9	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm0104318
	46228006	198006	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	364	5	0	7	2.1	CCn1c(=O)c2c(nc(Cc3ccccc3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL593217	198006	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	364	5	0	7	2.1	CCn1c(=O)c2c(nc(Cc3ccccc3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	137647216	157225	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	423	7	1	8	1.7	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4082841	157225	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	423	7	1	8	1.7	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	22266753	96336	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	260	2	2	6	-0.2	CCn1c(=O)c2[nH]c(-c3cn[nH]c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL264952	96336	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	260	2	2	6	-0.2	CCn1c(=O)c2[nH]c(-c3cn[nH]c3)nc2n(C)c1=O	10.1021/jm7014815
	46228003	198325	0	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	356	5	1	7	2.2	CCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL595431	198325	0	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	356	5	1	7	2.2	CCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	11381738	193368	0	None	-19	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	324	5	2	6	2.3	COc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)c1	10.1016/j.bmcl.2009.03.142
	CHEMBL549477	193368	0	None	-19	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	324	5	2	6	2.3	COc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)c1	10.1016/j.bmcl.2009.03.142
	10918042	119566	0	None	-4	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 88-165Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 88-165	ChEMBL	494	6	2	8	4.9	CCCCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL350830	119566	0	None	-4	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 88-165Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 88-165	ChEMBL	494	6	2	8	4.9	CCCCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	44406398	72623	0	None	30	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	527	8	1	9	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccccc5C(F)(F)F)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200739	72623	0	None	30	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	527	8	1	9	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccccc5C(F)(F)F)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	9805713	162284	0	None	-2238	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	493	5	4	8	1.3	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)[C@H](O)[C@@H]2O	10.1021/jm9905965
	CHEMBL417292	162284	0	None	-2238	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	493	5	4	8	1.3	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)[C@H](O)[C@@H]2O	10.1021/jm9905965
	135522362	99546	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	472	8	1	10	0.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(C)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL286838	99546	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	472	8	1	10	0.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(C)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	11531253	76997	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	391	6	2	7	0.7	CCCCNS(=O)(=O)c1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1021/jm060277v
	CHEMBL208550	76997	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	391	6	2	7	0.7	CCCCNS(=O)(=O)c1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1021/jm060277v
	21874685	188299	0	None	-64	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	292	3	1	7	2.1	Nc1nc(-c2ccco2)c2nnn(Cc3ccccc3)c2n1	10.1021/jm800961g
	CHEMBL507426	188299	0	None	-64	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	292	3	1	7	2.1	Nc1nc(-c2ccco2)c2nnn(Cc3ccccc3)c2n1	10.1021/jm800961g
	44406570	72488	0	None	18	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccc(OC)cc5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200230	72488	0	None	18	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccc(OC)cc5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	9857735	189225	0	None	-61	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	307	3	2	8	1.7	Nc1nc(-c2ccco2)c2nnn(Cc3ccccc3N)c2n1	10.1021/jm800961g
	CHEMBL516483	189225	0	None	-61	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	307	3	2	8	1.7	Nc1nc(-c2ccco2)c2nnn(Cc3ccccc3N)c2n1	10.1021/jm800961g
	11503979	73044	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	482	7	2	7	2.6	COc1cc(OCC(=O)NCc2ccc(Cl)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	CHEMBL201580	73044	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	482	7	2	7	2.6	COc1cc(OCC(=O)NCc2ccc(Cl)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	11645609	140500	0	None	33	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	329	4	2	6	0.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL382413	140500	0	None	33	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	329	4	2	6	0.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44452535	155219	0	None	-38	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	295	4	2	7	1.9	OCCNc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	CHEMBL405868	155219	0	None	-38	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	295	4	2	7	1.9	OCCNc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	45273122	194086	0	None	-128	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	308	4	2	5	2.6	Cc1ccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)cc1	10.1016/j.bmcl.2009.03.142
	CHEMBL557696	194086	0	None	-128	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	308	4	2	5	2.6	Cc1ccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)cc1	10.1016/j.bmcl.2009.03.142
	136044108	129157	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	344	5	3	7	1.8	CCCn1c(=O)c2nc(-c3cccc(O)c3O)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL36740	129157	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	344	5	3	7	1.8	CCCn1c(=O)c2nc(-c3cccc(O)c3O)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	11059351	119427	0	None	-6	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 116-134Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 116-134	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccccc3OC)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL349611	119427	0	None	-6	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 116-134Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 116-134	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccccc3OC)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	45268920	195001	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	334	6	1	7	1.7	CCn1c(=O)c2[nH]c(-c3cccs3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL564680	195001	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	334	6	1	7	1.7	CCn1c(=O)c2[nH]c(-c3cccs3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	46228002	199750	0	None	4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	340	5	1	7	1.7	CCn1c(=O)c2[nH]c(Cc3ccco3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL604896	199750	0	None	4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	340	5	1	7	1.7	CCn1c(=O)c2[nH]c(Cc3ccco3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	11582537	168724	0	None	-2	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	420	7	1	7	3.1	CC(C)Cn1c(=O)c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2n(CC(C)C)c1=O	10.1021/jm051268+
	CHEMBL441530	168724	0	None	-2	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	420	7	1	7	3.1	CC(C)Cn1c(=O)c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2n(CC(C)C)c1=O	10.1021/jm051268+
	54577823	80570	0	None	-30	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	289	2	0	7	0.1	Cn1c(=O)c2c(nc3n2CCCN3CC2CC2)n(C)c1=O	10.1016/j.ejmech.2011.05.023
	CHEMBL2153627	80570	0	None	-30	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	289	2	0	7	0.1	Cn1c(=O)c2c(nc3n2CCCN3CC2CC2)n(C)c1=O	10.1016/j.ejmech.2011.05.023
	70696537	75084	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	304	7	3	5	1.8	COc1cccc2cc(C(=O)NCCCCCO)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	CHEMBL2042075	75084	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	304	7	3	5	1.8	COc1cccc2cc(C(=O)NCCCCCO)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	145987354	166599	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	609	18	1	10	3.6	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCN(CC)CC)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	CHEMBL4291015	166599	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	609	18	1	10	3.6	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCN(CC)CC)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	44410566	140835	0	None	-1071	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	496	7	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4cccc(OC)c4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL383836	140835	0	None	-1071	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	496	7	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4cccc(OC)c4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	10311510	123042	0	None	-25	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cellsBinding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5OC)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL361826	123042	0	None	-25	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cellsBinding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5OC)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	10311510	123042	0	None	-25	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5OC)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL361826	123042	0	None	-25	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5OC)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	9954406	96239	0	None	-31	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	430	9	2	6	3.6	CCCn1c(=O)c2nc([C@]34CC[C@](CCCC(=O)O)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	CHEMBL264070	96239	0	None	-31	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	430	9	2	6	3.6	CCCn1c(=O)c2nc([C@]34CC[C@](CCCC(=O)O)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	377	2707	47	None	-1479	15	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm701594y
	425	2707	47	None	-1479	15	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm701594y
	448222	2707	47	None	-1479	15	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm701594y
	CHEMBL464859	2707	47	None	-1479	15	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm701594y
	10431614	57808	0	None	-14	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 115-143Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 115-143	ChEMBL	408	3	2	8	3.6	Cn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL167753	57808	0	None	-14	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 115-143Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 115-143	ChEMBL	408	3	2	8	3.6	Cn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	44406582	72525	0	None	7	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	474	8	1	10	3.0	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5cccc(C)c5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200350	72525	0	None	7	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	474	8	1	10	3.0	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5cccc(C)c5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	21874721	178002	0	None	-58	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	328	3	1	7	2.4	Nc1nc(-c2ccco2)c2nnn(Cc3cc(F)ccc3F)c2n1	10.1021/jm800961g
	CHEMBL467245	178002	0	None	-58	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	328	3	1	7	2.4	Nc1nc(-c2ccco2)c2nnn(Cc3cc(F)ccc3F)c2n1	10.1021/jm800961g
	21874639	178067	0	None	-3	4	Human	5.9	pKi	=	5.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	311	3	2	8	0.8	Nc1nc(-c2cnn[nH]2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	CHEMBL467655	178067	0	None	-3	4	Human	5.9	pKi	=	5.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	311	3	2	8	0.8	Nc1nc(-c2cnn[nH]2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	11282829	204282	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	471	7	2	9	2.2	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Oc4cccc([N+](=O)[O-])c4)cc3)nc2c1=O	10.1021/jm0310030
	CHEMBL8495	204282	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	471	7	2	9	2.2	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Oc4cccc([N+](=O)[O-])c4)cc3)nc2c1=O	10.1021/jm0310030
	135443378	109136	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	623	11	2	9	4.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5ccccc5C(F)(F)F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32229	109136	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	623	11	2	9	4.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5ccccc5C(F)(F)F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135443378	109136	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	623	11	2	9	4.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5ccccc5C(F)(F)F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32229	109136	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	623	11	2	9	4.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5ccccc5C(F)(F)F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	57429602	156685	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	CHEMBL4076435	156685	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2021.113907
	44236568	155917	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	486	6	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4067401	155917	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	486	6	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	69028196	159004	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	491	9	1	9	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(OC)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4102641	159004	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	491	9	1	9	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(OC)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	21958783	94143	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	364	5	2	6	2.0	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL252068	94143	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	364	5	2	6	2.0	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	22266766	154921	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	498	6	2	9	2.8	O=c1[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	CHEMBL403975	154921	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	498	6	2	9	2.8	O=c1[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	10308937	154950	0	None	9	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	350	5	2	6	1.7	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL404130	154950	0	None	9	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	350	5	2	6	1.7	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	11952665	5958	0	None	19	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	262	2	1	4	3.3	c1coc(-c2nc3[nH]ccc3cc2-c2ccncn2)c1	10.1016/j.bmcl.2010.01.077
	CHEMBL1080512	5958	0	None	19	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	262	2	1	4	3.3	c1coc(-c2nc3[nH]ccc3cc2-c2ccncn2)c1	10.1016/j.bmcl.2010.01.077
	53318744	57693	0	None	2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	334	4	1	5	3.9	O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)C1CCCC1	10.1021/ml100249e
	CHEMBL1672616	57693	0	None	2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	334	4	1	5	3.9	O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)C1CCCC1	10.1021/ml100249e
	11690561	77884	0	None	34	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	5	1	7	2.9	CCn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(CC)c1=O	10.1021/jm7014815
	CHEMBL210808	77884	0	None	34	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	5	1	7	2.9	CCn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(CC)c1=O	10.1021/jm7014815
	21958583	95785	0	None	7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	382	5	1	7	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL260976	95785	0	None	7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	382	5	1	7	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	9930130	10685	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	387	5	1	5	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171897	10685	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	387	5	1	5	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(F)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49798140	10754	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	484	9	1	7	3.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N(C)CCOC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172442	10754	0	None	2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	484	9	1	7	3.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N(C)CCOC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	11690561	77884	0	None	34	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	432	5	1	7	2.9	CCn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(CC)c1=O	10.1021/jm051268+
	CHEMBL210808	77884	0	None	34	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	432	5	1	7	2.9	CCn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(CC)c1=O	10.1021/jm051268+
	10970525	99472	0	None	8	3	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	364	4	3	5	2.3	CCCn1c(=O)[nH]c2[nH]c(-c3ccc4cc(C(=O)O)ccc4c3)nc2c1=O	10.1021/jm011049y
	CHEMBL286350	99472	0	None	8	3	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	364	4	3	5	2.3	CCCn1c(=O)[nH]c2[nH]c(-c3ccc4cc(C(=O)O)ccc4c3)nc2c1=O	10.1021/jm011049y
	44451252	95517	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	503	6	1	8	2.0	COc1ccc(N2CCN(C(=O)COc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1	10.1016/j.bmc.2008.01.002
	CHEMBL259529	95517	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	503	6	1	8	2.0	COc1ccc(N2CCN(C(=O)COc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1	10.1016/j.bmc.2008.01.002
	44451050	95528	0	None	23	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	7	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259581	95528	0	None	23	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	7	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	168292492	191034	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	352	4	2	6	1.1	CCCn1c(=O)[nH]c2nc(-c3cccc(S(=O)(=O)F)c3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5195884	191034	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	352	4	2	6	1.1	CCCn1c(=O)[nH]c2nc(-c3cccc(S(=O)(=O)F)c3)[nH]c2c1=O	10.1039/d2md00132b
	10377463	95853	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	251	1	1	6	2.1	Nc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	CHEMBL261345	95853	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	251	1	1	6	2.1	Nc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	136042347	70816	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	482	9	2	8	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955925	70816	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	482	9	2	8	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	11525368	73026	0	None	8	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	457	7	2	7	3.1	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)cc2n(CC)c1=O	10.1021/jm0506221
	CHEMBL201496	73026	0	None	8	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	457	7	2	7	3.1	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)cc2n(CC)c1=O	10.1021/jm0506221
	44450929	95358	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	544	9	2	7	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(O)(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL258809	95358	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	544	9	2	7	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(O)(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	44451491	96215	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	475	5	1	9	0.8	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ncccn5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL263895	96215	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	475	5	1	9	0.8	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ncccn5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	69032552	157400	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	491	9	1	9	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5cccc(OC)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4084707	157400	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	491	9	1	9	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5cccc(OC)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	155562321	175263	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2[C@@H]1c1ccoc1	10.1021/acs.jmedchem.9b01340
	CHEMBL4585472	175263	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2[C@@H]1c1ccoc1	10.1021/acs.jmedchem.9b01340
	11720513	72666	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	517	10	3	7	4.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(NC(C)=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL200967	72666	0	None	4	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	517	10	3	7	4.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(NC(C)=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11561715	73039	0	None	8	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	462	9	2	7	2.7	COCCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc21	10.1021/jm0506221
	CHEMBL201554	73039	0	None	8	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	462	9	2	7	2.7	COCCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc21	10.1021/jm0506221
	46228018	198143	0	None	7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	354	5	0	8	1.7	CCn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL594271	198143	0	None	7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	354	5	0	8	1.7	CCn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	44574282	178195	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	432	6	2	6	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL468920	178195	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	432	6	2	6	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL5080757	212922	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccc(F)cc2)nc(N)nc1-c1ccco1	10.1021/acs.jmedchem.1c01636
	135416055	109980	0	None	5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	517	8	2	8	3.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(C(F)(F)F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32478	109980	0	None	5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	517	8	2	8	3.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(C(F)(F)F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	57429611	158993	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	446	6	2	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(=O)O)cc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4102581	158993	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	446	6	2	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(=O)O)cc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	11733601	119471	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 105-170Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 105-170	ChEMBL	484	6	2	8	5.2	CCCCn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL349954	119471	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 105-170Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 105-170	ChEMBL	484	6	2	8	5.2	CCCCn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	22283414	10548	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	359	4	2	5	3.7	COc1ccc(NC(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1170518	10548	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	359	4	2	5	3.7	COc1ccc(NC(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2011.02.053
	22283414	10548	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	359	4	2	5	3.7	COc1ccc(NC(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170518	10548	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	359	4	2	5	3.7	COc1ccc(NC(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	9869857	66481	7	None	-109	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL186113	66481	7	None	-109	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	482	8	5	14	-0.6	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	44520983	199543	0	None	-380	4	Human	5.9	pKi	=	5.9	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	326	5	2	7	1.8	CCn1ccnc1CNC(=O)c1cc(-c2ccc(C)o2)nc(N)n1	10.1016/j.bmc.2009.07.078
	CHEMBL603748	199543	0	None	-380	4	Human	5.9	pKi	=	5.9	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	326	5	2	7	1.8	CCn1ccnc1CNC(=O)c1cc(-c2ccc(C)o2)nc(N)n1	10.1016/j.bmc.2009.07.078
	127043669	140634	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	439	9	1	8	3.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(O)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	CHEMBL3828002	140634	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	439	9	1	8	3.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(O)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	44406403	72626	0	None	26	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	489	9	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5cccc(OC)c5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200747	72626	0	None	26	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	489	9	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5cccc(OC)c5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11577210	74230	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	518	10	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC(=O)OCC)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL202980	74230	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	518	10	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC(=O)OCC)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	168292492	191034	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	352	4	2	6	1.1	CCCn1c(=O)[nH]c2nc(-c3cccc(S(=O)(=O)F)c3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5195884	191034	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	352	4	2	6	1.1	CCCn1c(=O)[nH]c2nc(-c3cccc(S(=O)(=O)F)c3)[nH]c2c1=O	10.1039/d2md00132b
	135465796	110068	0	None	18	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	571	9	2	9	3.4	CC(C)Cn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)nn3C)[nH]c2n(CC(C)C)c1=O	10.1021/jm0309654
	CHEMBL32534	110068	0	None	18	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	571	9	2	9	3.4	CC(C)Cn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)nn3C)[nH]c2n(CC(C)C)c1=O	10.1021/jm0309654
	10938276	119359	0	None	-29	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 118-146Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 118-146	ChEMBL	402	4	2	8	3.7	CCn1cc2c(nc(NC(=O)Nc3ccc(C)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL348975	119359	0	None	-29	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 118-146Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 118-146	ChEMBL	402	4	2	8	3.7	CCn1cc2c(nc(NC(=O)Nc3ccc(C)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	21874626	190072	0	None	-12	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	335	4	2	8	1.2	NC(=O)c1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	CHEMBL518178	190072	0	None	-12	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	335	4	2	8	1.2	NC(=O)c1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	22995178	99535	3	None	3	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	232	4	1	5	0.3	C=CCn1c(=O)c2nc[nH]c2n(CC=C)c1=O	10.1021/jm0104318
	CHEMBL286785	99535	3	None	3	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	232	4	1	5	0.3	C=CCn1c(=O)c2nc[nH]c2n(CC=C)c1=O	10.1021/jm0104318
	1908	204273	30	None	-3	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	336	2	2	7	-0.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(C)c1=O	10.1021/jm0104318
	CHEMBL8488	204273	30	None	-3	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	336	2	2	7	-0.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(C)c1=O	10.1021/jm0104318
	1908	204273	30	None	-3	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranesBinding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes	ChEMBL	336	2	2	7	-0.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(C)c1=O	10.1021/jm0310030
	CHEMBL8488	204273	30	None	-3	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranesBinding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes	ChEMBL	336	2	2	7	-0.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(C)c1=O	10.1021/jm0310030
	1908	204273	30	None	-3	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	336	2	2	7	-0.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(C)c1=O	10.1021/jm060277v
	CHEMBL8488	204273	30	None	-3	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	336	2	2	7	-0.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(C)c1=O	10.1021/jm060277v
	46880471	5985	0	None	10	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncc2)c(-c2cocn2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1080677	5985	0	None	10	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncc2)c(-c2cocn2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	44406625	72460	0	None	22	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5cccc(Cl)c5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200146	72460	0	None	22	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5cccc(Cl)c5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	21874538	168864	0	None	-11	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	333	3	2	9	1.4	Nc1nc(-c2ccco2)c2nnn(Cc3ccc4[nH]nnc4c3)c2n1	10.1021/jm800961g
	CHEMBL442670	168864	0	None	-11	4	Human	6.9	pKi	=	6.9	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	333	3	2	9	1.4	Nc1nc(-c2ccco2)c2nnn(Cc3ccc4[nH]nnc4c3)c2n1	10.1021/jm800961g
	46233379	198645	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	416	5	0	7	2.9	CCn1c(=O)c2c(nc(Cc3c(F)cccc3F)n2C)n(Cc2cccs2)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL597560	198645	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	416	5	0	7	2.9	CCn1c(=O)c2c(nc(Cc3c(F)cccc3F)n2C)n(Cc2cccs2)c1=O	10.1016/j.bmc.2010.01.028
	44437219	90206	0	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	340	3	0	8	0.3	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccccn2)n(C)c1=O	10.1016/j.bmc.2007.07.051
	CHEMBL239018	90206	0	None	-1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	340	3	0	8	0.3	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccccn2)n(C)c1=O	10.1016/j.bmc.2007.07.051
	24894016	64135	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	297	2	3	5	2.5	O=C(Nc1ccc(O)c(O)c1)c1coc2ccccc2c1=O	10.1016/j.ejmech.2012.05.033
	CHEMBL1814066	64135	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	297	2	3	5	2.5	O=C(Nc1ccc(O)c(O)c1)c1coc2ccccc2c1=O	10.1016/j.ejmech.2012.05.033
	11133843	57141	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 107-172Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 107-172	ChEMBL	434	6	2	8	4.3	CCCCn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165620	57141	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 107-172Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 107-172	ChEMBL	434	6	2	8	4.3	CCCCn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	10994317	56784	0	None	-8	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 115-161Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 115-161	ChEMBL	470	5	2	8	4.8	CCCn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164509	56784	0	None	-8	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 115-161Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 115-161	ChEMBL	470	5	2	8	4.8	CCCn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	44406588	132999	0	None	6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5cccc(OC)c5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL370860	132999	0	None	6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5cccc(OC)c5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	45267990	194420	0	None	-53	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	328	4	2	5	2.9	Nc1nc(C(=O)NCc2ccccc2Cl)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL560904	194420	0	None	-53	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	328	4	2	5	2.9	Nc1nc(C(=O)NCc2ccccc2Cl)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	136044107	130689	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	344	5	3	7	1.8	CCCn1c(=O)c2nc(-c3cc(O)ccc3O)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL36867	130689	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	344	5	3	7	1.8	CCCn1c(=O)c2nc(-c3cc(O)ccc3O)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	162666539	181698	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	276	4	2	4	1.9	CC1=C(C(=O)OCC2CC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4783992	181698	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	276	4	2	4	1.9	CC1=C(C(=O)OCC2CC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	45272308	193667	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	318	6	1	7	1.2	CCn1c(=O)c2[nH]c(-c3ccco3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL551761	193667	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	318	6	1	7	1.2	CCn1c(=O)c2[nH]c(-c3ccco3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	46233315	198692	0	None	4	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	372	5	1	7	2.7	CCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2cccs2)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL597955	198692	0	None	4	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	372	5	1	7	2.7	CCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2cccs2)c1=O	10.1016/j.bmc.2010.01.028
	164622009	185497	0	None	-309	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK cell membrane incubated for 30 mins by microplate beta scintillation counting based radioligand inhibition assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK cell membrane incubated for 30 mins by microplate beta scintillation counting based radioligand inhibition assay	ChEMBL	426	8	4	9	0.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.ejmech.2021.113607
	CHEMBL4871554	185497	0	None	-309	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK cell membrane incubated for 30 mins by microplate beta scintillation counting based radioligand inhibition assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK cell membrane incubated for 30 mins by microplate beta scintillation counting based radioligand inhibition assay	ChEMBL	426	8	4	9	0.6	CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.ejmech.2021.113607
	1882	90207	56	None	3	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	242	2	0	6	-0.3	Cn1c(=O)c2c(ncn2CCCl)n(C)c1=O	10.1021/jm0104318
	CHEMBL23903	90207	56	None	3	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	242	2	0	6	-0.3	Cn1c(=O)c2c(ncn2CCCl)n(C)c1=O	10.1021/jm0104318
	439176	98156	63	None	-54	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PSB-298 from human adenosine A2B receptor expressed in HEK293 cells at 10 uM; Less than 10% inhibitionDisplacement of [3H]PSB-298 from human adenosine A2B receptor expressed in HEK293 cells at 10 uM; Less than 10% inhibition	ChEMBL	297	3	3	9	-0.6	CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm031092g
	CHEMBL277041	98156	63	None	-54	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PSB-298 from human adenosine A2B receptor expressed in HEK293 cells at 10 uM; Less than 10% inhibitionDisplacement of [3H]PSB-298 from human adenosine A2B receptor expressed in HEK293 cells at 10 uM; Less than 10% inhibition	ChEMBL	297	3	3	9	-0.6	CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm031092g
	44236632	158110	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	441	6	1	8	2.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C#N)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4092863	158110	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	441	6	1	8	2.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C#N)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	69031810	158298	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	545	9	1	9	4.0	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(OC(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4094895	158298	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	545	9	1	9	4.0	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(OC(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	11654460	94110	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251869	94110	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	9890439	94111	0	None	10	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251870	94111	0	None	10	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	22266775	94170	0	None	29	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	459	8	1	9	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cc(-c5ccccc5)on4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL252245	94170	0	None	29	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	459	8	1	9	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cc(-c5ccccc5)on4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	22266741	154529	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	500	6	2	9	3.1	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL401834	154529	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	500	6	2	9	3.1	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	46880510	6065	0	None	11	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	4	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2ccncc2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081041	6065	0	None	11	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	4	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2ccncc2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	135874416	95928	0	None	35	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	467	8	2	8	2.7	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(F)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL261809	95928	0	None	35	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	467	8	2	8	2.7	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(F)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	44406611	72393	0	None	40	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	485	8	1	11	2.5	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccc(C#N)cc5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL199895	72393	0	None	40	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	485	8	1	11	2.5	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccc(C#N)cc5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	22266775	94170	0	None	29	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	459	8	1	9	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cc(-c5ccccc5)on4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL252245	94170	0	None	29	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	459	8	1	9	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cc(-c5ccccc5)on4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11654460	94110	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(CCC)c1=O	10.1021/jm7014815
	CHEMBL251869	94110	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(CCC)c1=O	10.1021/jm7014815
	9890439	94111	0	None	10	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1021/jm7014815
	CHEMBL251870	94111	0	None	10	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1021/jm7014815
	11568203	95784	0	None	28	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	5	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL260975	95784	0	None	28	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	5	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	49797772	10740	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	466	7	1	6	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(CN4CCCC4=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172276	10740	0	None	1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	466	7	1	6	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(CN4CCCC4=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	11654460	94110	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL251869	94110	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(CCC)c1=O	10.1021/jm051268+
	9890439	94111	0	None	10	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL251870	94111	0	None	10	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1021/jm051268+
	136042331	70798	0	None	48	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	476	8	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C)cccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955906	70798	0	None	48	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	476	8	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C)cccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	11670078	72420	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	474	9	2	6	4.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199999	72420	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	474	9	2	6	4.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL5086487	213251	0	None	-5	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		CCNc1nc(-c2ccccc2)c(C#N)c(-c2cccc(C#N)c2)n1	10.1021/acs.jmedchem.1c01636
	136042351	70792	0	None	53	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	492	9	2	10	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(OC)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955900	70792	0	None	53	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	492	9	2	10	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(OC)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	44450828	157141	0	None	44	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	472	6	1	6	3.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL408185	157141	0	None	44	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	472	6	1	6	3.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc21	10.1016/j.bmc.2008.01.002
	11089092	139243	0	None	4	3	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	340	5	3	5	1.6	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(/C=C/C(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL37987	139243	0	None	4	3	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	340	5	3	5	1.6	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(/C=C/C(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL5071174	212471	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(Nc2ccccc2)nc1-c1ccco1	10.1021/acs.jmedchem.1c01636
	11038429	118977	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	502	8	2	7	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL34543	118977	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	502	8	2	7	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)nc2c1=O	10.1021/jm011049y
	44451049	159623	0	None	74	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	535	7	1	7	3.5	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5Cl)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL410934	159623	0	None	74	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	535	7	1	7	3.5	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5Cl)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	46228058	198365	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	384	6	0	8	2.6	CCCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL595658	198365	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	384	6	0	8	2.6	CCCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	136042328	70788	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	507	9	2	11	2.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc([N+](=O)[O-])ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955894	70788	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	507	9	2	11	2.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc([N+](=O)[O-])ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	11586663	71710	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	229	1	1	7	0.4	Cc1cc2c(nc(-n3nccn3)n2C)c(N)n1	10.1021/jm058018d
	CHEMBL197682	71710	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	229	1	1	7	0.4	Cc1cc2c(nc(-n3nccn3)n2C)c(N)n1	10.1021/jm058018d
	137660519	158851	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	437	7	1	8	2.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCCCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4100823	158851	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	437	7	1	8	2.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCCCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	137645935	157022	0	None	-354	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	446	6	1	8	3.5	COc1cnc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3ccc(F)cc3)nc12	10.1021/acs.jmedchem.6b01584
	CHEMBL4080594	157022	0	None	-354	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	446	6	1	8	3.5	COc1cnc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3ccc(F)cc3)nc12	10.1021/acs.jmedchem.6b01584
	44308394	102149	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	224	2	0	7	-1.0	COCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1021/jm0104318
	CHEMBL304319	102149	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	224	2	0	7	-1.0	COCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1021/jm0104318
	404	4023	30	None	-229	11	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/acs.jmedchem.1c01636
	432	4023	30	None	-229	11	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/acs.jmedchem.1c01636
	5697	4023	30	None	-229	11	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/acs.jmedchem.1c01636
	CHEMBL273094	4023	30	None	-229	11	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/acs.jmedchem.1c01636
	22266744	95932	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	302	4	2	6	1.0	CCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3cn[nH]c3)nc21	10.1021/jm7014815
	CHEMBL261817	95932	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	302	4	2	6	1.0	CCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3cn[nH]c3)nc21	10.1021/jm7014815
	9923269	95571	0	None	-75	4	Human	6.9	pKi	=	6.9	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	324	3	2	8	2.0	Nc1nc(-c2ccco2)c2ncn(C(=O)NCc3ccco3)c2n1	10.1021/jm4011669
	CHEMBL259832	95571	0	None	-75	4	Human	6.9	pKi	=	6.9	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	324	3	2	8	2.0	Nc1nc(-c2ccco2)c2ncn(C(=O)NCc3ccco3)c2n1	10.1021/jm4011669
	11720443	140107	0	None	5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4F)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL381473	140107	0	None	5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4F)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	168281755	190301	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	368	5	2	7	1.1	CCCn1c(=O)[nH]c2nc(-c3cccc(OS(=O)(=O)F)c3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5185103	190301	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	368	5	2	7	1.1	CCCn1c(=O)[nH]c2nc(-c3cccc(OS(=O)(=O)F)c3)[nH]c2c1=O	10.1039/d2md00132b
	10884265	57094	0	None	-588	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 128-156Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 128-156	ChEMBL	418	3	2	10	2.6	Cn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165224	57094	0	None	-588	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 128-156Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 128-156	ChEMBL	418	3	2	10	2.6	Cn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	76011	201953	7	None	-2	3	Rat	4.9	pKi	=	4.9	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	256	3	0	6	0.1	Cn1c(=O)c2c(ncn2CCCCl)n(C)c1=O	10.1021/jm0104318
	CHEMBL67323	201953	7	None	-2	3	Rat	4.9	pKi	=	4.9	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	256	3	0	6	0.1	Cn1c(=O)c2c(ncn2CCCCl)n(C)c1=O	10.1021/jm0104318
	11784369	119407	0	None	-4	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 118-173Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 118-173	ChEMBL	401	6	1	8	3.3	CCCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL349464	119407	0	None	-4	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 118-173Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 118-173	ChEMBL	401	6	1	8	3.3	CCCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11683855	72242	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	452	6	2	7	2.4	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)Nc1ccc(F)cc1	10.1021/jm0506221
	CHEMBL199353	72242	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	452	6	2	7	2.4	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)Nc1ccc(F)cc1	10.1021/jm0506221
	44452454	95495	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	332	4	0	7	3.7	c1coc(-c2nc3c(OCc4ccoc4)nc4ccccc4n3n2)c1	10.1016/j.bmc.2007.10.103
	CHEMBL259430	95495	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	332	4	0	7	3.7	c1coc(-c2nc3c(OCc4ccoc4)nc4ccccc4n3n2)c1	10.1016/j.bmc.2007.10.103
	44316331	203778	0	None	-97	3	Rat	5.8	pKi	=	5.8	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	CHEMBL80686	203778	0	None	-97	3	Rat	5.8	pKi	=	5.8	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	24812771	175124	4	None	-16	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of human adenosine A2B receptorInhibition of human adenosine A2B receptor	ChEMBL	344	5	1	7	1.9	COC[C@H]1CCCN1c1cc(NC(C)=O)nc(-n2nc(C)cc2C)n1	10.1021/jm800908d
	CHEMBL458224	175124	4	None	-16	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of human adenosine A2B receptorInhibition of human adenosine A2B receptor	ChEMBL	344	5	1	7	1.9	COC[C@H]1CCCN1c1cc(NC(C)=O)nc(-n2nc(C)cc2C)n1	10.1021/jm800908d
	44390527	64201	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5cccc(F)c5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL181468	64201	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5cccc(F)c5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	44442167	154333	0	None	-204	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	602	8	5	11	2.3	CC1(C)c2ccc(C(=O)NCCc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2C(C)(C)N1[O]	10.1016/j.bmcl.2007.07.035
	CHEMBL400746	154333	0	None	-204	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	602	8	5	11	2.3	CC1(C)c2ccc(C(=O)NCCc3ccc(Nc4ncnc5c4ncn5[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)cc3)cc2C(C)(C)N1[O]	10.1016/j.bmcl.2007.07.035
	217940	201777	27	None	-	1	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	219	1	0	7	-1.0	Cn1c(=O)c2c(ncn2CC#N)n(C)c1=O	10.1021/jm0104318
	CHEMBL66058	201777	27	None	-	1	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	219	1	0	7	-1.0	Cn1c(=O)c2c(ncn2CC#N)n(C)c1=O	10.1021/jm0104318
	45268928	194462	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	331	7	2	6	1.3	CCCn1c(=O)c2[nH]c(-c3ccc[nH]3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL561168	194462	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	331	7	2	6	1.3	CCCn1c(=O)c2[nH]c(-c3ccc[nH]3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11711754	72243	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	434	6	2	7	2.3	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)Nc1ccccc1	10.1021/jm0506221
	CHEMBL199354	72243	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	434	6	2	7	2.3	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)Nc1ccccc1	10.1021/jm0506221
	127026188	137544	0	None	-1348	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	329	3	2	5	2.7	Nc1nc(C(=O)NCc2cccc3cccnc23)c2ccccc2n1	10.1016/j.bmcl.2015.11.048
	CHEMBL3765818	137544	0	None	-1348	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	329	3	2	5	2.7	Nc1nc(C(=O)NCc2cccc3cccnc23)c2ccccc2n1	10.1016/j.bmcl.2015.11.048
	76320870	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3091699	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.5b01586
	76320870	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL3091699	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.7b00138
	76320870	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091699	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	76320870	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/ml400185v
	CHEMBL3091699	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/ml400185v
	76320870	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL3091699	103353	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	135443367	484	0	None	22	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	382	484	0	None	22	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	CHEMBL33455	484	0	None	22	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	135443367	484	0	None	22	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	382	484	0	None	22	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	CHEMBL33455	484	0	None	22	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	10.1021/jm0309654
	135915276	158063	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	451	7	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC#Cc4ccc(F)cc4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4092291	158063	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	451	7	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC#Cc4ccc(F)cc4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	22266761	94106	0	None	229	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	418	6	2	9	1.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccccc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251854	94106	0	None	229	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	418	6	2	9	1.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccccc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	22266751	94119	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	497	6	2	8	3.4	O=c1[nH]c2nc(-c3cnn(Cc4cc(-c5ccc(C(F)(F)F)cc5)on4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	CHEMBL251881	94119	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	497	6	2	8	3.4	O=c1[nH]c2nc(-c3cnn(Cc4cc(-c5ccc(C(F)(F)F)cc5)on4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	22266776	165951	0	None	93	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	486	6	2	9	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL427887	165951	0	None	93	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	486	6	2	9	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	135874413	95930	0	None	22	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	449	8	2	8	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccccc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL261810	95930	0	None	22	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	449	8	2	8	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccccc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	49797793	10738	0	None	11	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	427	6	1	7	3.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)OC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172274	10738	0	None	11	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	427	6	1	7	3.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)OC)cc3)sc12	10.1016/j.bmcl.2010.05.056
	137638964	156308	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	288	3	2	5	1.6	CC1=C(C(=O)OC(C)C)[C@@H](c2ccco2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL4071734	156308	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	288	3	2	5	1.6	CC1=C(C(=O)OC(C)C)[C@@H](c2ccco2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	10882425	78744	0	None	13	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	342	6	3	5	1.5	CCCCn1c(=O)[nH]c2nc(-c3ccc(CC(=O)O)cc3)[nH]c2c1=O	10.1021/jm011049y
	CHEMBL2113345	78744	0	None	13	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	342	6	3	5	1.5	CCCCn1c(=O)[nH]c2nc(-c3ccc(CC(=O)O)cc3)[nH]c2c1=O	10.1021/jm011049y
	11611298	138680	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	412	5	2	9	1.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4nncs4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL378815	138680	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	412	5	2	9	1.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4nncs4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44451048	95527	0	None	15	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	519	7	1	7	3.0	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL259580	95527	0	None	15	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	519	7	1	7	3.0	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	155511376	168977	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)O[C@@H](C)C(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4435630	168977	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)O[C@@H](C)C(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	45272259	193960	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	478	10	2	9	2.0	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccn4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL556389	193960	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	478	10	2	9	2.0	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccn4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	45269711	194659	0	None	11	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	493	10	3	9	2.3	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(O)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL562427	194659	0	None	11	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	493	10	3	9	2.3	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(O)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11660995	72452	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	385	8	2	6	2.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL200112	72452	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	385	8	2	6	2.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	136042352	70793	0	None	17	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	540	8	2	9	3.3	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Br)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955901	70793	0	None	17	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	540	8	2	9	3.3	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Br)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	9910158	32219	0	None	-10	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 107-210Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 107-210	ChEMBL	422	4	2	8	4.1	CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL141154	32219	0	None	-10	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 107-210Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 107-210	ChEMBL	422	4	2	8	4.1	CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	9910158	32219	0	None	-10	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 107-210Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 107-210	ChEMBL	422	4	2	8	4.1	CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL141154	32219	0	None	-10	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 107-210Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 107-210	ChEMBL	422	4	2	8	4.1	CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	11080788	56451	0	None	-7	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 124-180Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 124-180	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3cccc(OC)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164325	56451	0	None	-7	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 124-180Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 124-180	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3cccc(OC)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11733556	119499	0	None	-10	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 124-180Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 124-180	ChEMBL	480	5	2	8	4.6	CCCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL350205	119499	0	None	-10	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 124-180Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 124-180	ChEMBL	480	5	2	8	4.6	CCCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11780616	201908	5	None	1	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	270	4	0	6	0.5	Cn1c(=O)c2c(ncn2CCCCCl)n(C)c1=O	10.1021/jm0104318
	CHEMBL67060	201908	5	None	1	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	270	4	0	6	0.5	Cn1c(=O)c2c(ncn2CCCCCl)n(C)c1=O	10.1021/jm0104318
	2153	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	2153	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	2620	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	2620	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	413	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	413	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	CHEMBL190	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	CHEMBL190	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	DB00277	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	DB00277	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Binding affinity to rat adenosine A2B receptorBinding affinity to rat adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	2153	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	2620	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	413	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	CHEMBL190	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	DB00277	3728	108	None	-1	14	Rat	4.8	pKi	=	4.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	11509299	72422	0	None	2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	387	6	1	8	1.2	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1OC	10.1021/jm0506221
	CHEMBL200012	72422	0	None	2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	387	6	1	8	1.2	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1OC	10.1021/jm0506221
	2917279	181085	15	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	4	2	4	2.3	CCCOC(=O)C1=C(C)NC(=O)NC1c1cccs1	10.1021/acs.jmedchem.0c01431
	CHEMBL4776470	181085	15	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	4	2	4	2.3	CCCOC(=O)C1=C(C)NC(=O)NC1c1cccs1	10.1021/acs.jmedchem.0c01431
	9814428	71138	0	None	-45	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	286	5	1	8	1.3	CCCCCc1nc(N)c2nc(-n3nccn3)n(C)c2n1	10.1021/jm058018d
	CHEMBL196258	71138	0	None	-45	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	286	5	1	8	1.3	CCCCCc1nc(N)c2nc(-n3nccn3)n(C)c2n1	10.1021/jm058018d
	11822168	201952	0	None	-6	4	Rat	4.8	pKi	=	4.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	284	4	1	5	1.1	Cn1c(=O)n(CCCc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	CHEMBL67313	201952	0	None	-6	4	Rat	4.8	pKi	=	4.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	284	4	1	5	1.1	Cn1c(=O)n(CCCc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	11610869	79831	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	393	5	3	8	-1.0	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)NCC(=O)O)cc3)[nH]c2n(C)c1=O	10.1021/jm060277v
	CHEMBL213878	79831	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	393	5	3	8	-1.0	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)NCC(=O)O)cc3)[nH]c2n(C)c1=O	10.1021/jm060277v
	71451329	80592	0	None	-5128	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	372	5	1	7	1.4	CCCn1c(=O)c2[nH]c(C3C4CC5OC(=O)C3C5C4)nc2n(CCC)c1=O	10.1016/j.ejmech.2011.05.023
	CHEMBL2153721	80592	0	None	-5128	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	372	5	1	7	1.4	CCCn1c(=O)c2[nH]c(C3C4CC5OC(=O)C3C5C4)nc2n(CCC)c1=O	10.1016/j.ejmech.2011.05.023
	44308307	102156	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	346	3	1	9	0.4	Cn1c(=O)c2nc(-c3ccc([N+](=O)[O-])cc3[N+](=O)[O-])[nH]c2n(C)c1=O	10.1021/jm0104318
	CHEMBL304356	102156	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	346	3	1	9	0.4	Cn1c(=O)c2nc(-c3ccc([N+](=O)[O-])cc3[N+](=O)[O-])[nH]c2n(C)c1=O	10.1021/jm0104318
	11530568	73000	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	359	5	2	7	0.7	COc1cc(OCC(=O)O)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	CHEMBL201330	73000	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	359	5	2	7	0.7	COc1cc(OCC(=O)O)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	44588437	174971	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	342	5	2	7	2.3	CCCn1c(=O)c2c(cc(-c3ccc(N)cc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457880	174971	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	342	5	2	7	2.3	CCCn1c(=O)c2c(cc(-c3ccc(N)cc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	11393155	193931	0	None	-44	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	324	5	2	6	2.3	COc1ccccc1CNC(=O)c1cc(-c2ccco2)nc(N)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL556083	193931	0	None	-44	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	324	5	2	6	2.3	COc1ccccc1CNC(=O)c1cc(-c2ccco2)nc(N)n1	10.1016/j.bmcl.2009.03.142
	44449635	154642	0	None	-676	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	262	2	0	6	2.9	CN(C)c1nc(-c2nccs2)c2sccc2n1	10.1016/j.bmcl.2008.03.076
	CHEMBL402464	154642	0	None	-676	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	262	2	0	6	2.9	CN(C)c1nc(-c2nccs2)c2sccc2n1	10.1016/j.bmcl.2008.03.076
	155516146	169473	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	304	3	2	4	2.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4442922	169473	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	304	3	2	4	2.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	5130381	48790	13	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	296	3	2	5	2.9	CC1=C(C(=O)OC(C)C)C(c2cccs2)NC(S)=N1	10.1021/acs.jmedchem.0c01431
	CHEMBL1561375	48790	13	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	296	3	2	5	2.9	CC1=C(C(=O)OC(C)C)C(c2cccs2)NC(S)=N1	10.1021/acs.jmedchem.0c01431
	162671451	182273	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	292	4	2	4	2.3	CC1=C(C(=O)OCC2CC2)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4791727	182273	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	292	4	2	4	2.3	CC1=C(C(=O)OCC2CC2)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	5130381	48790	13	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	296	3	2	5	2.9	CC1=C(C(=O)OC(C)C)C(c2cccs2)NC(S)=N1	10.1021/ml400185v
	CHEMBL1561375	48790	13	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	296	3	2	5	2.9	CC1=C(C(=O)OC(C)C)C(c2cccs2)NC(S)=N1	10.1021/ml400185v
	11676113	73032	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	419	8	2	6	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201523	73032	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	419	8	2	6	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	25070230	200743	0	None	-15	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assayDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assay	ChEMBL	295	2	2	5	2.7	Oc1cccc(-c2nc(N3CCCCC3)c3nc[nH]c3n2)c1	10.1016/j.bmc.2019.06.034
	CHEMBL611021	200743	0	None	-15	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assayDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assay	ChEMBL	295	2	2	5	2.7	Oc1cccc(-c2nc(N3CCCCC3)c3nc[nH]c3n2)c1	10.1016/j.bmc.2019.06.034
	168288152	191224	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	394	6	1	7	2.0	CCCn1c(=O)c2[nH]c(-c3cccc(S(=O)(=O)F)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5198830	191224	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	394	6	1	7	2.0	CCCn1c(=O)c2[nH]c(-c3cccc(S(=O)(=O)F)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	67364057	73925	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	295	2	1	5	2.9	Cc1cc(-c2nnc(N)nc2-c2ccc(F)cc2)cc(C)n1	10.1021/jm201376w
	CHEMBL2024116	73925	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	295	2	1	5	2.9	Cc1cc(-c2nnc(N)nc2-c2ccc(F)cc2)cc(C)n1	10.1021/jm201376w
	136086750	8618	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	349	3	4	6	1.9	N=C1c2c(C(N)=O)nc(-c3ccccc3O)n2CN1c1ccc(O)cc1	10.1016/j.bmc.2010.03.048
	CHEMBL1095872	8618	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	349	3	4	6	1.9	N=C1c2c(C(N)=O)nc(-c3ccccc3O)n2CN1c1ccc(O)cc1	10.1016/j.bmc.2010.03.048
	CHEMBL5071873	212489	0	None	-20	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H] DPCPX from human recombinant A2B adenosine receptor expressed in HEK293 cells incubated for 30 mins by radioligand binding competition assayDisplacement of [3H] DPCPX from human recombinant A2B adenosine receptor expressed in HEK293 cells incubated for 30 mins by radioligand binding competition assay	ChEMBL		None	None	None		Cn1cc(-c2cnc(N)n3nc(-c4nccs4)nc23)ccc1=O	10.1021/acsmedchemlett.1c00599
	135489238	474	0	None	30	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	381	474	0	None	30	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	CHEMBL32802	474	0	None	30	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	135489238	474	0	None	30	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	381	474	0	None	30	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	CHEMBL32802	474	0	None	30	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	10.1021/jm0309654
	66892244	158374	0	None	32	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	491	8	1	9	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(OC)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4095686	158374	0	None	32	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	491	8	1	9	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(OC)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	11544506	84945	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	332	4	2	7	2.6	O=c1ccc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)c[nH]1	10.1021/jm061333v
	CHEMBL226238	84945	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	332	4	2	7	2.6	O=c1ccc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)c[nH]1	10.1021/jm061333v
	24827555	165864	0	None	25	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	445	5	1	8	2.6	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(-c4ccc(C(F)(F)F)nc4)c3)nc21	10.1021/jm7014815
	CHEMBL427736	165864	0	None	25	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	445	5	1	8	2.6	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(-c4ccc(C(F)(F)F)nc4)c3)nc21	10.1021/jm7014815
	11306173	166061	0	None	26	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	480	7	1	10	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4nc(-c5ccc(Cl)cc5)no4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL428086	166061	0	None	26	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	480	7	1	10	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4nc(-c5ccc(Cl)cc5)no4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	44574193	188651	0	None	61	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	418	5	2	6	2.7	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)NCc4ccccc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL511714	188651	0	None	61	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	418	5	2	6	2.7	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)NCc4ccccc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	11713561	72309	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	536	10	2	6	5.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(-c5ccccc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199583	72309	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	536	10	2	6	5.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(-c5ccccc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	2690	888	59	None	-30	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	384	888	59	None	-30	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	CHEMBL16687	888	59	None	-30	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	CHEMBL5084815	213153	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1cccc(-c2nc(Nc3ccccc3)nc(-c3ccccc3)c2C#N)c1	10.1021/acs.jmedchem.1c01636
	50941005	56969	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	297	5	1	5	3.7	CCCC(=O)Nc1cc(-c2ccco2)nc(-c2ccco2)n1	10.1021/jm100843z
	CHEMBL1650386	56969	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	297	5	1	5	3.7	CCCC(=O)Nc1cc(-c2ccco2)nc(-c2ccco2)n1	10.1021/jm100843z
	11524904	72990	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	436	6	2	6	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL201323	72990	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	436	6	2	6	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11576014	132473	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	450	8	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)n4ccc(N)n4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL370205	132473	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	450	8	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)n4ccc(N)n4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44451227	95925	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	532	10	1	8	2.4	COCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc2n(CCOC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL261790	95925	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	532	10	1	8	2.4	COCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc2n(CCOC)c1=O	10.1016/j.bmc.2008.01.002
	135493280	109876	0	None	28	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	483	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(Cl)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32425	109876	0	None	28	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	483	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(Cl)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	9945226	176395	0	None	-69	4	Human	6.8	pKi	=	6.8	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	326	3	1	7	2.8	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(Cl)c3)c2n1	10.1021/jm800961g
	CHEMBL462488	176395	0	None	-69	4	Human	6.8	pKi	=	6.8	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	326	3	1	7	2.8	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(Cl)c3)c2n1	10.1021/jm800961g
	10971099	56988	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells (95% confidence limits)Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells (95% confidence limits)	ChEMBL	387	5	1	8	2.9	CCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165073	56988	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells (95% confidence limits)Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells (95% confidence limits)	ChEMBL	387	5	1	8	2.9	CCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11732736	57260	0	None	-24	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 127-203Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 127-203	ChEMBL	430	6	2	8	4.5	CCCCn1cc2c(nc(NC(=O)Nc3ccc(C)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL166684	57260	0	None	-24	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 127-203Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 127-203	ChEMBL	430	6	2	8	4.5	CCCCn1cc2c(nc(NC(=O)Nc3ccc(C)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	10971841	57158	0	None	-17	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 140-186Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 140-186	ChEMBL	420	5	2	8	3.9	CCCn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165778	57158	0	None	-17	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 140-186Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 140-186	ChEMBL	420	5	2	8	3.9	CCCn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	46227994	198141	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	350	5	1	6	2.1	CCn1c(=O)c2[nH]c(Cc3ccccc3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL594255	198141	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	350	5	1	6	2.1	CCn1c(=O)c2[nH]c(Cc3ccccc3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	12905388	91323	2	None	3	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	1	1	5	-0.6	CCn1c(=O)c2nc[nH]c2n(C)c1=O	10.1021/jm0104318
	CHEMBL24107	91323	2	None	3	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	1	1	5	-0.6	CCn1c(=O)c2nc[nH]c2n(C)c1=O	10.1021/jm0104318
	135493285	99298	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	492	9	2	9	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(N(C)C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL285151	99298	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	492	9	2	9	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(N(C)C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	22282339	82677	1	None	-234	15	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H] DPCPX from rat adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from rat adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	CHEMBL2181976	82677	1	None	-234	15	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H] DPCPX from rat adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from rat adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	CHEMBL5084951	82677	1	None	-234	15	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H] DPCPX from rat adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from rat adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	44406397	72545	0	None	26	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	493	8	1	9	3.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5cccc(Cl)c5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200417	72545	0	None	26	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	493	8	1	9	3.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5cccc(Cl)c5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	9857422	188214	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	298	3	1	8	2.2	Nc1nc(-c2ccco2)c2nnn(Cc3ccsc3)c2n1	10.1021/jm800961g
	CHEMBL506101	188214	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	298	3	1	8	2.2	Nc1nc(-c2ccco2)c2nnn(Cc3ccsc3)c2n1	10.1021/jm800961g
	50940981	56977	0	None	-4	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	315	4	1	5	4.3	CCC(=O)Nc1cc(-c2ccsc2)nc(-c2ccsc2)n1	10.1021/jm100843z
	CHEMBL1650394	56977	0	None	-4	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	315	4	1	5	4.3	CCC(=O)Nc1cc(-c2ccsc2)nc(-c2ccsc2)n1	10.1021/jm100843z
	10928182	57136	0	None	-15	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 125-218Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 125-218	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(nc(NC(=O)Nc3ccccc3OC)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165560	57136	0	None	-15	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 125-218Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 125-218	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(nc(NC(=O)Nc3ccccc3OC)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11014188	117966	0	None	-6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	373	4	1	8	2.5	Cn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL341376	117966	0	None	-6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	373	4	1	8	2.5	Cn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11014188	117966	0	None	-6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	373	4	1	8	2.5	Cn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	CHEMBL341376	117966	0	None	-6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	373	4	1	8	2.5	Cn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	11524240	72238	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	404	5	2	6	2.3	Cn1c(=O)c2[nH]c(-c3cccc(OCC(=O)Nc4ccccc4)c3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL199330	72238	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	404	5	2	6	2.3	Cn1c(=O)c2[nH]c(-c3cccc(OCC(=O)Nc4ccccc4)c3)cc2n(C)c1=O	10.1021/jm0506221
	15578102	172648	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	271	1	1	6	0.9	Cn1c(=O)c2c(cc(-c3ccccc3)n2O)n(C)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL452359	172648	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	271	1	1	6	0.9	Cn1c(=O)c2c(cc(-c3ccccc3)n2O)n(C)c1=O	10.1016/j.bmc.2008.09.067
	50940976	56963	0	None	-316	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	391	4	1	7	3.6	CCC(=O)Nc1cc(-c2ccc3c(c2)OCO3)nc(-c2ccc3c(c2)OCO3)n1	10.1021/jm100843z
	CHEMBL1650380	56963	0	None	-316	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	391	4	1	7	3.6	CCC(=O)Nc1cc(-c2ccc3c(c2)OCO3)nc(-c2ccc3c(c2)OCO3)n1	10.1021/jm100843z
	10052252	96170	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5cccc(OC)c5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL263494	96170	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5cccc(OC)c5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	44451197	95433	0	None	39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	474	5	1	7	2.2	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)N1CCc2ccccc2C1	10.1016/j.bmc.2008.01.002
	CHEMBL259155	95433	0	None	39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	474	5	1	7	2.2	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)N1CCc2ccccc2C1	10.1016/j.bmc.2008.01.002
	11716665	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	5617	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	CHEMBL375293	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1021/jm061333v
	11716665	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1016/j.bmcl.2010.01.045
	5617	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1016/j.bmcl.2010.01.045
	CHEMBL375293	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	10.1016/j.bmcl.2010.01.045
	155533829	171306	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)O[C@H](C)C(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4469484	171306	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)O[C@H](C)C(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	11678808	72677	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	600	11	2	8	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(S(=O)(=O)c5ccccc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201042	72677	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	600	11	2	8	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(S(=O)(=O)c5ccccc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	66894039	156004	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	545	8	1	9	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(OC(F)(F)F)c5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4068331	156004	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	545	8	1	9	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(OC(F)(F)F)c5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	44236657	155782	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	460	7	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(=O)O)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4065780	155782	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	460	7	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(=O)O)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	22266759	94117	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	451	6	2	8	3.0	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cc(-c5ccc(Cl)cc5)on4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251879	94117	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	451	6	2	8	3.0	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cc(-c5ccc(Cl)cc5)on4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	24950370	178131	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	261	2	1	4	3.5	N#Cc1c(-c2ccccc2)cc(-c2ccco2)nc1N	10.1021/jm701594y
	CHEMBL468370	178131	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	261	2	1	4	3.5	N#Cc1c(-c2ccccc2)cc(-c2ccco2)nc1N	10.1021/jm701594y
	11067937	201917	0	None	-5	3	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	344	5	0	6	2.0	C=CCn1c(=O)c2c(nc(-c3ccccc3)n2CCCl)n(C)c1=O	10.1021/jm0104318
	CHEMBL67110	201917	0	None	-5	3	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	344	5	0	6	2.0	C=CCn1c(=O)c2c(nc(-c3ccccc3)n2CCCl)n(C)c1=O	10.1021/jm0104318
	9798466	133742	1	None	-218	6	Rat	5.8	pKi	=	5.8	Binding	In vivo binding affinity was evaluated against Alpha-2 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-2 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
	CHEMBL37170	133742	1	None	-218	6	Rat	5.8	pKi	=	5.8	Binding	In vivo binding affinity was evaluated against Alpha-2 adrenergic receptorIn vivo binding affinity was evaluated against Alpha-2 adrenergic receptor	ChEMBL	349	4	1	3	3.3	Cc1ccc(N2CCN(CC[C@@H]3NC(=O)c4ccccc43)CC2)cc1C	10.1016/s0960-894x(98)00252-2
	72697932	103537	0	None	-54	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	341	2	0	7	1.1	C#CCn1c(=O)c2c(nc3n2CCCN3C2CCCCC2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL3093321	103537	0	None	-54	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	341	2	0	7	1.1	C#CCn1c(=O)c2c(nc3n2CCCN3C2CCCCC2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	9824812	120616	0	None	-67	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1531-1920Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1531-1920	ChEMBL	446	4	2	9	4.1	COc1ccc(NC(=O)Nc2nc3nn(C(C)(C)C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	CHEMBL357663	120616	0	None	-67	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1531-1920Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1531-1920	ChEMBL	446	4	2	9	4.1	COc1ccc(NC(=O)Nc2nc3nn(C(C)(C)C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	22446266	201886	2	None	1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	236	4	1	5	0.7	CCCCn1c(=O)c2nc[nH]c2n(CC)c1=O	10.1021/jm0104318
	CHEMBL66881	201886	2	None	1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	236	4	1	5	0.7	CCCCn1c(=O)c2nc[nH]c2n(CC)c1=O	10.1021/jm0104318
	45273118	194787	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	520	11	2	9	2.7	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(N(C)C)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL563259	194787	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	520	11	2	9	2.7	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(N(C)C)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11685118	72667	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	526	10	2	6	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccc(F)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201006	72667	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	526	10	2	6	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccc(F)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	44451106	165819	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	411	4	1	7	0.4	CN1CCN(C(=O)COc2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)CC1	10.1016/j.bmc.2008.01.002
	CHEMBL427602	165819	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	411	4	1	7	0.4	CN1CCN(C(=O)COc2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)CC1	10.1016/j.bmc.2008.01.002
	1892	202338	74	None	34	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	224	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCO)n(C)c1=O	10.1021/jm0104318
	CHEMBL699	202338	74	None	34	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	224	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCO)n(C)c1=O	10.1021/jm0104318
	44452695	159003	0	None	-52	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	331	4	1	7	3.7	c1coc(CNc2nc3ccccc3n3nc(-c4ccco4)nc23)c1	10.1016/j.bmc.2007.10.103
	CHEMBL410264	159003	0	None	-52	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	331	4	1	7	3.7	c1coc(CNc2nc3ccccc3n3nc(-c4ccco4)nc23)c1	10.1016/j.bmc.2007.10.103
	10379032	7425	0	None	-4	4	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	282	3	1	5	1.3	C=CCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(C)c1=O	10.1021/jm0104318
	CHEMBL10873	7425	0	None	-4	4	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	282	3	1	5	1.3	C=CCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(C)c1=O	10.1021/jm0104318
	72697789	103531	0	None	-15	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	355	3	0	8	1.0	C#CCn1c(=O)c2c(nc3n2CCCN3Cc2cccs2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL3093315	103531	0	None	-15	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	355	3	0	8	1.0	C#CCn1c(=O)c2c(nc3n2CCCN3Cc2cccs2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	136002187	108331	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	275	1	2	8	-1.1	Cn1nc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1N	10.1021/jm0309654
	CHEMBL32098	108331	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	275	1	2	8	-1.1	Cn1nc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1N	10.1021/jm0309654
	156014066	176671	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	354	3	1	7	3.7	CC1=C(C(=O)OC(C)C)C(c2ccns2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4636018	176671	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	354	3	1	7	3.7	CC1=C(C(=O)OC(C)C)C(c2ccns2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	11133804	119507	0	None	-13	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 149-204Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 149-204	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(nc(NC(=O)Nc3cccc(OC)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL350261	119507	0	None	-13	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 149-204Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 149-204	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(nc(NC(=O)Nc3cccc(OC)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	3645619	2973	13	None	-112	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at Alpha-2 adrenergic receptorBinding affinity at Alpha-2 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
	975	2973	13	None	-112	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at Alpha-2 adrenergic receptorBinding affinity at Alpha-2 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
	CHEMBL45244	2973	13	None	-112	9	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at Alpha-2 adrenergic receptorBinding affinity at Alpha-2 adrenergic receptor	ChEMBL	334	4	1	4	2.4	N#Cc1ccccc1N1CCN(CC1)CNC(=O)c1cccc(c1)C	10.1021/jm970021c
	CHEMBL5072422	212499	0	None	-41	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(N)nc1-c1cccc(Cl)c1	10.1021/acs.jmedchem.1c01636
	101420	161478	17	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	208	2	1	5	-0.1	CCn1c(=O)c2nc[nH]c2n(CC)c1=O	10.1021/jm0104318
	CHEMBL416013	161478	17	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	208	2	1	5	-0.1	CCn1c(=O)c2nc[nH]c2n(CC)c1=O	10.1021/jm0104318
	9836304	176331	0	None	-7	4	Human	5.8	pKi	=	5.8	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	310	3	2	7	1.4	Nc1nc(-c2cc[nH]n2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	CHEMBL461858	176331	0	None	-7	4	Human	5.8	pKi	=	5.8	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	310	3	2	7	1.4	Nc1nc(-c2cc[nH]n2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	145993861	166833	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	567	15	1	10	2.5	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN(CC)CC)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	CHEMBL4295248	166833	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	567	15	1	10	2.5	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN(CC)CC)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	135522367	110161	0	None	31	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	493	8	2	10	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc5c(c4)OCO5)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32591	110161	0	None	31	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	493	8	2	10	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc5c(c4)OCO5)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135522367	110161	0	None	31	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	493	8	2	10	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc5c(c4)OCO5)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32591	110161	0	None	31	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	493	8	2	10	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc5c(c4)OCO5)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	11608581	72120	0	None	4	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	258	3	1	8	0.5	CCCc1nc(N)c2nc(-n3nccn3)n(C)c2n1	10.1021/jm058018d
	CHEMBL198942	72120	0	None	4	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	258	3	1	8	0.5	CCCc1nc(N)c2nc(-n3nccn3)n(C)c2n1	10.1021/jm058018d
	10150517	94279	0	None	15	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	382	6	2	6	2.3	CCCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL253048	94279	0	None	15	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	382	6	2	6	2.3	CCCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	136042355	70789	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	462	8	2	9	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955897	70789	0	None	12	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	462	8	2	9	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	44406642	72400	0	None	53	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	485	8	1	11	2.5	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(C#N)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL199908	72400	0	None	53	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	485	8	1	11	2.5	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(C#N)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	24827553	95567	0	None	24	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	433	5	1	8	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(-c4ccc(C(F)(F)F)nc4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL259772	95567	0	None	24	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	433	5	1	8	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(-c4ccc(C(F)(F)F)nc4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	53248698	60384	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	534	6	1	6	4.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CCN(C(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760886	60384	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	534	6	1	6	4.8	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@@H]3CCN(C(=O)c4cccc(C(F)(F)F)c4)C3)sc12	10.1016/j.bmcl.2011.02.053
	53248699	62758	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	548	8	2	6	6.0	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760897	62758	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	548	8	2	6	6.0	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1789197	62758	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	548	8	2	6	6.0	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)[C@H]3CC[C@H](NCc4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	49797749	10506	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	435	6	1	7	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4cccn4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170136	10506	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	435	6	1	7	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4cccn4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49798139	10557	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	495	6	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCN(C)CC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170583	10557	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	495	6	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCN(C)CC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	11575498	77901	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	426	7	1	7	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(Cl)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210938	77901	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	426	7	1	7	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(Cl)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11582697	139615	0	None	-2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	426	7	1	7	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(Cl)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL380284	139615	0	None	-2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	426	7	1	7	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(Cl)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	136042355	70789	0	None	12	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	462	8	2	9	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955897	70789	0	None	12	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	462	8	2	9	2.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	155561189	175078	0	None	2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	377	5	2	6	0.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N(C)C)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4581448	175078	0	None	2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	377	5	2	6	0.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N(C)C)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	11591558	72680	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	508	9	2	6	5.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201054	72680	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	508	9	2	6	5.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	128784	51511	36	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	312	5	1	5	2.4	CCCn1c(=O)c2nc(-c3ccccc3)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL158507	51511	36	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	312	5	1	5	2.4	CCCn1c(=O)c2nc(-c3ccccc3)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	128784	51511	36	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranesBinding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes	ChEMBL	312	5	1	5	2.4	CCCn1c(=O)c2nc(-c3ccccc3)[nH]c2n(CCC)c1=O	10.1021/jm0310030
	CHEMBL158507	51511	36	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranesBinding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes	ChEMBL	312	5	1	5	2.4	CCCn1c(=O)c2nc(-c3ccccc3)[nH]c2n(CCC)c1=O	10.1021/jm0310030
	11102838	168457	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	475	7	1	9	4.4	CSc1c2c(nc(NC(=O)Cc3ccc(CC(C)C)cc3)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL439447	168457	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	475	7	1	9	4.4	CSc1c2c(nc(NC(=O)Cc3ccc(CC(C)C)cc3)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	11133545	119951	0	None	-13	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	419	4	2	10	2.8	Cn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL354161	119951	0	None	-13	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	419	4	2	10	2.8	Cn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL5081556	212971	0	None	-5	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL		None	None	None		Nc1nc(-c2ccccc2)c2c(n1)-c1ccc(OCCCN3CCCC3)cc1C2=O	10.1021/acs.jmedchem.0c00914
	4882	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/acs.jmedchem.0c00237
	5311037	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/acs.jmedchem.0c00237
	5608	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/acs.jmedchem.0c00237
	CHEMBL431770	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/acs.jmedchem.0c00237
	DB11757	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/acs.jmedchem.0c00237
	4882	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/jm4011669
	5311037	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/jm4011669
	5608	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/jm4011669
	CHEMBL431770	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/jm4011669
	DB11757	2059	78	None	-104	6	Human	5.8	pKi	=	5.8	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	10.1021/jm4011669
	11144868	119354	0	None	-12	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 152-216Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 152-216	ChEMBL	452	3	2	8	3.7	Cn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL348925	119354	0	None	-12	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 152-216Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 152-216	ChEMBL	452	3	2	8	3.7	Cn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	21874681	188499	0	None	-114	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	321	4	2	8	2.2	CNc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	CHEMBL510134	188499	0	None	-114	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	321	4	2	8	2.2	CNc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	2882039	28012	11	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	294	3	1	4	2.7	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1C	10.1021/ml400185v
	CHEMBL1373953	28012	11	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	294	3	1	4	2.7	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1C	10.1021/ml400185v
	12267225	141085	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	255	1	1	4	1.2	Cn1c(=O)c2[nH]c(-c3ccccc3)cc2n(C)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL38528	141085	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	255	1	1	4	1.2	Cn1c(=O)c2[nH]c(-c3ccccc3)cc2n(C)c1=O	10.1016/j.bmc.2008.09.067
	44390549	63142	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccccc5Cl)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL179932	63142	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccccc5Cl)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	45268869	193868	0	None	-48	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	328	4	2	5	2.9	Nc1nc(C(=O)NCc2cccc(Cl)c2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL554623	193868	0	None	-48	4	Human	6.7	pKi	=	6.7	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	328	4	2	5	2.9	Nc1nc(C(=O)NCc2cccc(Cl)c2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	44520985	198166	0	None	-338	4	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	340	5	2	7	2.3	Cc1ccc(-c2cc(C(=O)NCc3nccn3C(C)C)nc(N)n2)o1	10.1016/j.bmc.2009.07.078
	CHEMBL594455	198166	0	None	-338	4	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	340	5	2	7	2.3	Cc1ccc(-c2cc(C(=O)NCc3nccn3C(C)C)nc(N)n2)o1	10.1016/j.bmc.2009.07.078
	135440428	78116	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL2112066	78116	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	483	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL5081937	212996	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		COc1ccc(-c2nc(Nc3ccccc3)nc(-c3ccccc3)c2C#N)cc1	10.1021/acs.jmedchem.1c01636
	CHEMBL5088089	213353	0	None	-13	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(N)nc1-c1cccc(F)c1	10.1021/acs.jmedchem.1c01636
	1329	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm0104318
	386	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm0104318
	CHEMBL183	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm0104318
	DB12946	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm0104318
	44406906	72450	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	447	7	3	7	1.8	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CCN)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL200105	72450	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	447	7	3	7	1.8	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CCN)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11547533	140369	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	482	7	2	7	2.6	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)NCc1ccc(Cl)cc1	10.1021/jm0506221
	CHEMBL382234	140369	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	482	7	2	7	2.6	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)NCc1ccc(Cl)cc1	10.1021/jm0506221
	10605011	118242	0	None	-4	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1681-1961Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1681-1961	ChEMBL	732	6	2	8	7.6	O=C(Nc1cccc(Cl)c1)Nc1nc2nn(CCc3cc(Br)c(Br)cc3Br)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL341852	118242	0	None	-4	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1681-1961Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1681-1961	ChEMBL	732	6	2	8	7.6	O=C(Nc1cccc(Cl)c1)Nc1nc2nn(CCc3cc(Br)c(Br)cc3Br)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	76320909	103543	0	None	-1513	6	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	300	1	1	5	1.0	Cn1c(=O)c2[nH]c([C@]34C[C@@H]5C[C@H](C[C@H]3C5)C4)nc2n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL3093327	103543	0	None	-1513	6	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	300	1	1	5	1.0	Cn1c(=O)c2[nH]c([C@]34C[C@@H]5C[C@H](C[C@H]3C5)C4)nc2n(C)c1=O	10.1016/j.bmc.2013.09.044
	15667105	108244	0	None	-263	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	384	7	1	5	3.6	CCCCn1c(=O)c2nc(C34CC5CC(CC3C5)C4)[nH]c2n(CCCC)c1=O	10.1039/C8MD00070K
	CHEMBL320872	108244	0	None	-263	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	384	7	1	5	3.6	CCCCn1c(=O)c2nc(C34CC5CC(CC3C5)C4)[nH]c2n(CCCC)c1=O	10.1039/C8MD00070K
	11689583	3153	24	None	-1513	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	386	7	2	6	2.1	OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3	10.1016/j.ejmech.2019.111879
	3285	3153	24	None	-1513	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	386	7	2	6	2.1	OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3	10.1016/j.ejmech.2019.111879
	CHEMBL1316674	3153	24	None	-1513	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	386	7	2	6	2.1	OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3	10.1016/j.ejmech.2019.111879
	11780616	201908	5	None	-1	4	Rat	4.7	pKi	=	4.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	270	4	0	6	0.5	Cn1c(=O)c2c(ncn2CCCCCl)n(C)c1=O	10.1021/jm0104318
	CHEMBL67060	201908	5	None	-1	4	Rat	4.7	pKi	=	4.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	270	4	0	6	0.5	Cn1c(=O)c2c(ncn2CCCCCl)n(C)c1=O	10.1021/jm0104318
	136044130	48832	0	None	4	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	402	8	3	8	1.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3O)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL156178	48832	0	None	4	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	402	8	3	8	1.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)O)cc3O)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL5090384	213475	0	None	-16	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(Nc2ccccc2)nc1-c1ccc2c(c1)OCO2	10.1021/acs.jmedchem.1c01636
	128525	154174	10	None	-5	6	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	CHEMBL39986	154174	10	None	-5	6	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	44401051	123839	0	None	-23442	4	Human	4.7	pKi	=	4.7	Binding	Binding affinity for human adenosine A2b receptor subtype expressed in CHO cellsBinding affinity for human adenosine A2b receptor subtype expressed in CHO cells	ChEMBL	355	3	4	9	0.4	O[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm049408n
	CHEMBL363807	123839	0	None	-23442	4	Human	4.7	pKi	=	4.7	Binding	Binding affinity for human adenosine A2b receptor subtype expressed in CHO cellsBinding affinity for human adenosine A2b receptor subtype expressed in CHO cells	ChEMBL	355	3	4	9	0.4	O[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm049408n
	11395785	185922	0	None	-15488	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation methodDisplacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation method	ChEMBL	410	5	4	9	0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.7b00457
	CHEMBL487754	185922	0	None	-15488	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation methodDisplacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation method	ChEMBL	410	5	4	9	0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NC4CCCC4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.7b00457
	22282339	82677	1	None	-275	15	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H] DPCPX from mouse adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from mouse adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	CHEMBL2181976	82677	1	None	-275	15	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H] DPCPX from mouse adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from mouse adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	CHEMBL5084951	82677	1	None	-275	15	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H] DPCPX from mouse adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from mouse adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	377	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation methodDisplacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation method	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.7b00457
	425	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation methodDisplacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation method	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.7b00457
	448222	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation methodDisplacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation method	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.7b00457
	CHEMBL464859	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation methodDisplacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation method	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.7b00457
	377	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	425	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	448222	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	CHEMBL464859	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	377	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assayDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/ml200189u
	425	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assayDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/ml200189u
	448222	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assayDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/ml200189u
	CHEMBL464859	2707	47	None	-1479	15	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assayDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assay	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/ml200189u
	162660983	181279	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	294	2	2	4	2.4	CC1=C(C(=O)OC(C)(C)C)C(c2ccoc2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4778860	181279	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	294	2	2	4	2.4	CC1=C(C(=O)OC(C)(C)C)C(c2ccoc2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	135546649	116123	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	479	9	2	9	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33695	116123	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	479	9	2	9	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135546649	116123	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	479	9	2	9	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33695	116123	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	479	9	2	9	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	66894703	157039	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	511	8	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(F)cc5F)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4080807	157039	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	511	8	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(F)cc5F)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44588438	188520	0	None	8	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	342	5	3	6	2.3	CCCn1c(=O)c2[nH]c(-c3ccc(N)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL510409	188520	0	None	8	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	342	5	3	6	2.3	CCCn1c(=O)c2[nH]c(-c3ccc(N)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	136042333	70801	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	514	8	2	9	3.4	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)c(F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955909	70801	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	514	8	2	9	3.4	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)c(F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	44406545	72531	0	None	25	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5Cl)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200370	72531	0	None	25	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5Cl)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	21958557	95332	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	364	5	1	7	1.7	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL258686	95332	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	364	5	1	7	1.7	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O	10.1021/jm7014815
	49797795	10501	0	None	4	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	447	6	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(S(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170129	10501	0	None	4	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	447	6	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(S(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49797904	10627	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(C)c3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171163	10627	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(C)c3)sc12	10.1016/j.bmcl.2010.05.056
	52948949	19059	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	494	8	3	4	5.4	O=C(NCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290322	19059	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	494	8	3	4	5.4	O=C(NCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	11588630	77738	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	364	5	1	7	1.8	CCn1c(=O)c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2n(CC)c1=O	10.1021/jm051268+
	CHEMBL210271	77738	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	364	5	1	7	1.8	CCn1c(=O)c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2n(CC)c1=O	10.1021/jm051268+
	640847	99584	1	None	7	4	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	256	2	2	4	1.1	CCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm011049y
	CHEMBL287129	99584	1	None	7	4	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	256	2	2	4	1.1	CCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm011049y
	11591029	140752	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	476	9	3	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL383321	140752	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	476	9	3	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	46228022	198217	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	368	6	0	8	2.1	CCCn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL594734	198217	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	368	6	0	8	2.1	CCCn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	176407	4069	76	None	-34	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.bmc.2010.02.014
	405	4069	76	None	-34	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.bmc.2010.02.014
	CHEMBL113142	4069	76	None	-34	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.bmc.2010.02.014
	DB08770	4069	76	None	-34	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.bmc.2010.02.014
	11570614	140141	0	None	8	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	586	9	2	6	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL381522	140141	0	None	8	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	586	9	2	6	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44185935	184941	0	None	4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	417	5	2	6	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCCCC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486281	184941	0	None	4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	417	5	2	6	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCCCC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	11627494	71962	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	502	10	2	7	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL198403	71962	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	502	10	2	7	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11517907	74333	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	444	5	3	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4nc5ccccc5[nH]4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL203043	74333	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	444	5	3	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4nc5ccccc5[nH]4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44236603	156835	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	446	6	2	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4078316	156835	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	446	6	2	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	1509337	48850	13	None	-10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in cell membranes after 30 mins by beta-scintillation counting methodDisplacement of [3H]DPCPX from human A2B receptor expressed in cell membranes after 30 mins by beta-scintillation counting method	ChEMBL	324	5	1	7	2.2	COc1cccc(COC(=O)c2nn(-c3ccccc3)nc2N)c1	10.1021/acs.jmedchem.8b00204
	CHEMBL1561896	48850	13	None	-10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in cell membranes after 30 mins by beta-scintillation counting methodDisplacement of [3H]DPCPX from human A2B receptor expressed in cell membranes after 30 mins by beta-scintillation counting method	ChEMBL	324	5	1	7	2.2	COc1cccc(COC(=O)c2nn(-c3ccccc3)nc2N)c1	10.1021/acs.jmedchem.8b00204
	46233161	198829	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	358	7	1	6	2.7	CCCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(CCSCC)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL598819	198829	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	358	7	1	6	2.7	CCCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(CCSCC)c1=O	10.1016/j.bmc.2010.01.028
	3286	3148	24	None	4	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1039/d2md00132b
	5311479	3148	24	None	4	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1039/d2md00132b
	CHEMBL8565	3148	24	None	4	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1039/d2md00132b
	135404340	81971	0	None	-229	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	427	7	2	4	4.1	CCCN1C(=O)N2C[C@@H](CC)N=C2c2[nH]c(C34CCC(CCC(=O)O)(CC3)CC4)nc21	10.1021/jm060539t
	CHEMBL217268	81971	0	None	-229	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	427	7	2	4	4.1	CCCN1C(=O)N2C[C@@H](CC)N=C2c2[nH]c(C34CCC(CCC(=O)O)(CC3)CC4)nc21	10.1021/jm060539t
	11408692	75194	0	None	-2511	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	466	6	5	10	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL204527	75194	0	None	-2511	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	466	6	5	10	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	3467695	90499	36	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	328	4	2	4	3.1	CC1=C(C(=O)OCc2ccccc2)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL239336	90499	36	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	328	4	2	4	3.1	CC1=C(C(=O)OCc2ccccc2)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	21874668	176306	0	None	-21	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	282	3	1	8	1.7	Nc1nc(-c2ccco2)c2nnn(Cc3ccco3)c2n1	10.1021/jm800961g
	CHEMBL461650	176306	0	None	-21	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	282	3	1	8	1.7	Nc1nc(-c2ccco2)c2nnn(Cc3ccco3)c2n1	10.1021/jm800961g
	145986422	166582	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	565	13	1	10	2.2	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN3CCCC3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	CHEMBL4290710	166582	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	565	13	1	10	2.2	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN3CCCC3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	76313652	103356	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091701	103356	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	76313652	103356	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=S)N1	10.1021/ml400185v
	CHEMBL3091701	103356	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)C(c2ccoc2)NC(=S)N1	10.1021/ml400185v
	3286	3148	24	None	4	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1039/d2md00132b
	5311479	3148	24	None	4	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1039/d2md00132b
	CHEMBL8565	3148	24	None	4	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1039/d2md00132b
	3286	3148	24	None	-16	9	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	5311479	3148	24	None	-16	9	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	CHEMBL8565	3148	24	None	-16	9	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	95028	93362	28	None	-3	4	Human	4.7	pKi	=	4.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	270	2	0	6	0.5	Cn1c(=O)c2c(ncn2Cc2ccccc2)n(C)c1=O	10.1021/jm0104318
	CHEMBL24759	93362	28	None	-3	4	Human	4.7	pKi	=	4.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	270	2	0	6	0.5	Cn1c(=O)c2c(ncn2Cc2ccccc2)n(C)c1=O	10.1021/jm0104318
	44406334	72572	0	None	16	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	489	9	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccccc5OC)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200509	72572	0	None	16	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	489	9	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccccc5OC)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11112543	56843	0	None	-10	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 162-237Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 162-237	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3ccccc3OC)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164647	56843	0	None	-10	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 162-237Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 162-237	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3ccccc3OC)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	2748296	181562	9	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	4	2.1	CC1=C(C(=O)OCC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4782393	181562	9	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	4	2.1	CC1=C(C(=O)OCC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	11267343	174768	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	325	5	1	4	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(C)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457442	174768	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	325	5	1	4	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(C)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	21916371	95426	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	5	1	7	3.0	CC(C)Cn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL259129	95426	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	5	1	7	3.0	CC(C)Cn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	9902562	172056	0	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	341	3	1	8	2.4	Cc1cnc(-c2nc(N)nc3c2nnn3Cc2ccccc2F)s1	10.1021/jm800961g
	CHEMBL449469	172056	0	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	341	3	1	8	2.4	Cc1cnc(-c2nc(N)nc3c2nnn3Cc2ccccc2F)s1	10.1021/jm800961g
	11649548	72421	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	539	10	3	8	2.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(S(N)(=O)=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL200011	72421	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	539	10	3	8	2.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(S(N)(=O)=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	46227958	198420	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	7	1	7	2.8	CSCCn1c(=O)c2[nH]c(Cc3c(F)cccc3F)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL596125	198420	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	7	1	7	2.8	CSCCn1c(=O)c2[nH]c(Cc3c(F)cccc3F)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	45268854	194383	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	392	10	1	8	1.9	CCSCCn1c(=O)c2[nH]c(Cc3ccco3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL560562	194383	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	392	10	1	8	1.9	CCSCCn1c(=O)c2[nH]c(Cc3ccco3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	19574107	75075	0	None	-50	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	300	3	2	4	3.0	COc1cccc2cc(C(=O)NC3CCCCC3)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	CHEMBL2042059	75075	0	None	-50	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	300	3	2	4	3.0	COc1cccc2cc(C(=O)NC3CCCCC3)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cellsBinding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.bmcl.2004.11.044
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cellsBinding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.bmcl.2004.11.044
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cellsBinding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.bmcl.2004.11.044
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cellsBinding affinity against Adenosine A2b receptor labeled by [3H]ZM-241385 in membranes prepared from HEK-A2B cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.bmcl.2004.11.044
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm201292w
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm201292w
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm201292w
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm201292w
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2016.11.007
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2016.11.007
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2016.11.007
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2016.11.007
	44451329	95723	0	None	204	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	5	1	7	2.7	Cc1ccc(N2CCN(C(=O)C(C)Oc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1	10.1016/j.bmc.2008.01.002
	CHEMBL260692	95723	0	None	204	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	5	1	7	2.7	Cc1ccc(N2CCN(C(=O)C(C)Oc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1	10.1016/j.bmc.2008.01.002
	44451127	160721	0	None	44	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	569	7	1	7	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL412112	160721	0	None	44	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	569	7	1	7	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	46880475	5445	0	None	7	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	333	4	1	3	4.3	O=C(Nc1ccc(-c2ccncc2)c(-c2cccc(F)c2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1076587	5445	0	None	7	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	333	4	1	3	4.3	O=C(Nc1ccc(-c2ccncc2)c(-c2cccc(F)c2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	46880474	6255	0	None	30	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	333	4	1	3	4.3	O=C(Nc1ccc(-c2ccncc2)c(-c2ccccc2F)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1082028	6255	0	None	30	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	333	4	1	3	4.3	O=C(Nc1ccc(-c2ccncc2)c(-c2ccccc2F)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	53318745	57710	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	325	4	1	6	2.7	O=C(Nc1cnc(-c2ccncc2F)c(-c2cnco2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672633	57710	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	325	4	1	6	2.7	O=C(Nc1cnc(-c2ccncc2F)c(-c2cnco2)n1)C1CC1	10.1021/ml100249e
	44574222	188709	0	None	-5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	478	8	2	6	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL512276	188709	0	None	-5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	478	8	2	6	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	22266746	157210	0	None	36	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	350	4	1	7	1.4	CCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL408266	157210	0	None	36	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	350	4	1	7	1.4	CCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O	10.1021/jm7014815
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm051268+
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm051268+
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm051268+
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm051268+
	449	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2018.11.045
	453	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2018.11.045
	6603931	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2018.11.045
	CHEMBL273807	2595	44	None	-1	9	Human	8.7	pKi	=	8.7	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1016/j.ejmech.2018.11.045
	44451127	160721	0	None	44	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	569	7	1	7	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL412112	160721	0	None	44	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	569	7	1	7	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	44574192	178222	0	None	20	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	444	3	1	6	2.9	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCc5ccccc5C4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL469136	178222	0	None	20	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	444	3	1	6	2.9	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCc5ccccc5C4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	11801496	98279	0	None	7	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	587	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL278039	98279	0	None	7	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	587	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	168297247	191769	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	327	4	2	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(N=C=S)cc3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5207498	191769	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	327	4	2	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(N=C=S)cc3)[nH]c2c1=O	10.1039/d2md00132b
	11649544	72771	0	None	9	4	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	538	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201145	72771	0	None	9	4	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	538	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	57429615	159193	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	442	4	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4105001	159193	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	442	4	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	16072021	57688	0	None	19	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672611	57688	0	None	19	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)C1CC1	10.1021/ml100249e
	16071777	57696	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	320	4	1	5	3.5	Cc1ccc(-c2nc(NC(=O)C3CC3)cnc2-c2ccncc2)o1	10.1021/ml100249e
	CHEMBL1672619	57696	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	320	4	1	5	3.5	Cc1ccc(-c2nc(NC(=O)C3CC3)cnc2-c2ccncc2)o1	10.1021/ml100249e
	11649544	72771	0	None	9	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	538	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL201145	72771	0	None	9	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	538	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	10767043	58699	0	None	7	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	479	9	2	7	3.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL16929	58699	0	None	7	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	479	9	2	7	3.5	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	9827315	95389	0	None	40	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	500	8	1	6	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL258978	95389	0	None	40	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	500	8	1	6	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	46837704	10508	0	None	32	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	436	7	3	5	3.3	CCCn1c(=O)[nH]c2cc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)[nH]c2c1=O	10.1016/j.ejmech.2010.03.011
	CHEMBL1170166	10508	0	None	32	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	436	7	3	5	3.3	CCCn1c(=O)[nH]c2cc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)[nH]c2c1=O	10.1016/j.ejmech.2010.03.011
	10840167	58851	0	None	3	6	Human	8.6	pKi	=	8.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	539	9	2	7	4.2	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL17003	58851	0	None	3	6	Human	8.6	pKi	=	8.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	539	9	2	7	4.2	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	168271107	189466	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	394	6	1	7	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)F)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5172513	189466	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	394	6	1	7	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)F)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	44450997	95576	0	None	398	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	500	7	1	6	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL259857	95576	0	None	398	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	500	7	1	6	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	11123022	131590	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	438	5	1	5	3.0	CCCn1c(=O)c2nc(-c3ccc(I)cc3)[nH]c2n(CCC)c1=O	10.1021/jm011049y
	CHEMBL36963	131590	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	438	5	1	5	3.0	CCCn1c(=O)c2nc(-c3ccc(I)cc3)[nH]c2n(CCC)c1=O	10.1021/jm011049y
	44450997	95576	0	None	398	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	500	7	1	6	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL259857	95576	0	None	398	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	500	7	1	6	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	76321753	105022	0	None	-10	4	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	371	7	1	7	1.3	CCN(CC)CCOc1ccc(-c2nc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.ejmech.2014.01.045
	CHEMBL3121721	105022	0	None	-10	4	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	371	7	1	7	1.3	CCN(CC)CCOc1ccc(-c2nc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.ejmech.2014.01.045
	57429644	158787	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	557	9	1	8	4.0	CCCn1c(=O)c2[nH]c(-c3cnn(CCC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4100199	158787	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	557	9	1	8	4.0	CCCn1c(=O)c2[nH]c(-c3cnn(CCC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44587957	188217	0	None	35	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	559	10	2	8	3.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL506179	188217	0	None	35	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	559	10	2	8	3.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	11684443	132625	0	None	4	4	Human	8.6	pKi	=	8.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL370378	132625	0	None	4	4	Human	8.6	pKi	=	8.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11684443	132625	0	None	4	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL370378	132625	0	None	4	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	11111247	119213	0	None	4	3	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	362	4	2	4	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(Br)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL34762	119213	0	None	4	3	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	362	4	2	4	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(Br)cc3)nc2c1=O	10.1021/jm011049y
	72197880	90353	0	None	-4	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	347	4	1	5	4.7	O=C(Nc1nc(-c2ccccc2)c(-c2ccncc2)s1)c1ccco1	10.1016/j.ejmech.2019.111879
	CHEMBL2391834	90353	0	None	-4	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	347	4	1	5	4.7	O=C(Nc1nc(-c2ccccc2)c(-c2ccncc2)s1)c1ccco1	10.1016/j.ejmech.2019.111879
	57429616	157128	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	458	5	2	7	2.6	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4081707	157128	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	458	5	2	7	2.6	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	44574117	188712	0	None	-1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	404	4	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL512290	188712	0	None	-1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	404	4	2	6	3.0	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccccc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	44451330	95724	0	None	53	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	5	1	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260693	95724	0	None	53	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	5	1	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	168297723	191844	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	327	4	2	6	2.2	CCCn1c(=O)[nH]c2nc(-c3cccc(N=C=S)c3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5208506	191844	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	327	4	2	6	2.2	CCCn1c(=O)[nH]c2nc(-c3cccc(N=C=S)c3)[nH]c2c1=O	10.1039/d2md00132b
	44219683	194811	0	None	33	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	555	10	2	8	3.4	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL563425	194811	0	None	33	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	555	10	2	8	3.4	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	44450981	95480	0	None	112	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	522	5	2	7	2.8	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(O)(c5ccc(Cl)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259360	95480	0	None	112	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	522	5	2	7	2.8	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(O)(c5ccc(Cl)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	76318040	105023	0	None	-10	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	383	5	2	7	1.4	Cn1c(=O)c2[nH]c(-c3ccc(OCCC4CCNCC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	CHEMBL3121722	105023	0	None	-10	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	383	5	2	7	1.4	Cn1c(=O)c2[nH]c(-c3ccc(OCCC4CCNCC4)cc3)nc2n(C)c1=O	10.1016/j.ejmech.2014.01.045
	10962751	162074	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	560	9	2	8	2.7	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(=O)OCc5ccccc5)CC4)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL416963	162074	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	560	9	2	8	2.7	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(=O)OCc5ccccc5)CC4)cc3)nc2c1=O	10.1021/jm011049y
	135522388	99637	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	543	9	2	9	2.9	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL287529	99637	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	543	9	2	9	2.9	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135522388	99637	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	543	9	2	9	2.9	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL287529	99637	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	543	9	2	9	2.9	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10007115	115831	0	None	15	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human adenosine A2b receptorBinding affinity to human adenosine A2b receptor	ChEMBL	527	8	1	8	5.7	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2010.09.043
	CHEMBL335950	115831	0	None	15	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human adenosine A2b receptorBinding affinity to human adenosine A2b receptor	ChEMBL	527	8	1	8	5.7	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1016/j.bmc.2010.09.043
	10007115	115831	0	None	15	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	527	8	1	8	5.7	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/acs.jmedchem.5b01586
	CHEMBL335950	115831	0	None	15	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	527	8	1	8	5.7	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/acs.jmedchem.5b01586
	10007115	115831	0	None	15	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	527	8	1	8	5.7	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL335950	115831	0	None	15	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	527	8	1	8	5.7	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	155530961	171015	0	None	15	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 60 mins by topcount scintillation counting methodDisplacement of [3H]DPCPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 60 mins by topcount scintillation counting method	ChEMBL	513	7	1	8	5.8	O=C(Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12)c1cccc2ccccc12	10.1021/acs.jmedchem.9b00071
	CHEMBL4465141	171015	0	None	15	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 60 mins by topcount scintillation counting methodDisplacement of [3H]DPCPX from recombinant human A2B adenosine receptor expressed in HEK293 cell membranes measured after 60 mins by topcount scintillation counting method	ChEMBL	513	7	1	8	5.8	O=C(Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12)c1cccc2ccccc12	10.1021/acs.jmedchem.9b00071
	136042327	70787	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	512	8	2	9	3.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc6ccccc6cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955893	70787	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	512	8	2	9	3.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc6ccccc6cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	135874424	95391	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	469	8	2	8	2.9	CCCn1c(=O)c2[nH]c(-c3ccn(CC(=O)Nc4ccc(Cl)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL258987	95391	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	469	8	2	8	2.9	CCCn1c(=O)c2[nH]c(-c3ccn(CC(=O)Nc4ccc(Cl)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	24827554	95525	0	None	17	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	5	1	8	2.8	CCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3cnn(-c4ccc(C(F)(F)F)nc4)c3)nc21	10.1021/jm7014815
	CHEMBL259565	95525	0	None	17	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	5	1	8	2.8	CCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3cnn(-c4ccc(C(F)(F)F)nc4)c3)nc21	10.1021/jm7014815
	52950040	18952	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	523	10	2	5	6.1	CC[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289569	18952	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	523	10	2	5	6.1	CC[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	11547107	76712	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(C(F)(F)F)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL207434	76712	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(C(F)(F)F)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11495611	138541	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	426	7	1	7	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL378652	138541	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	426	7	1	7	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11503942	72729	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	480	8	2	6	3.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccc(Cl)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL201109	72729	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	480	8	2	6	3.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccc(Cl)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44451230	95926	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	573	9	1	8	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(=O)Oc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL261792	95926	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	573	9	1	8	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(=O)Oc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	44451492	158517	0	None	17	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	487	5	1	7	2.3	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)N1CCN(c2ccccc2)CC1	10.1016/j.bmc.2008.01.002
	CHEMBL409726	158517	0	None	17	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	487	5	1	7	2.3	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)N1CCN(c2ccccc2)CC1	10.1016/j.bmc.2008.01.002
	50940978	56968	0	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	283	4	1	5	3.3	CCC(=O)Nc1cc(-c2ccco2)nc(-c2ccco2)n1	10.1021/jm100843z
	CHEMBL1650385	56968	0	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	283	4	1	5	3.3	CCC(=O)Nc1cc(-c2ccco2)nc(-c2ccco2)n1	10.1021/jm100843z
	127033039	138459	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.0c00564
	CHEMBL3785582	138459	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.0c00564
	127033039	138459	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785582	138459	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.5b01586
	127033039	138459	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.9b01340
	CHEMBL3785582	138459	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	323	3	1	6	3.5	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.9b01340
	136044106	49664	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	344	5	3	7	1.8	CCCn1c(=O)c2nc(-c3ccc(O)cc3O)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL156863	49664	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	344	5	3	7	1.8	CCCn1c(=O)c2nc(-c3ccc(O)cc3O)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	45267991	194421	0	None	4	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	468	10	2	10	1.6	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccon4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL560905	194421	0	None	4	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	468	10	2	10	1.6	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccon4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11525816	72998	0	None	15	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	477	9	3	8	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ncccc4O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201329	72998	0	None	15	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	477	9	3	8	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ncccc4O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44450904	95639	0	None	28	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	528	9	1	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260180	95639	0	None	28	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	528	9	1	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	9887859	113000	0	None	-10000	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2011.11.037
	CHEMBL118923	113000	0	None	-10000	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2011.11.037
	CHEMBL332091	113000	0	None	-10000	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.bmc.2011.11.037
	137636200	155513	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	425	9	1	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN(CC)CC)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4062691	155513	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	425	9	1	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN(CC)CC)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	9887859	113000	0	None	-10000	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm020974x
	CHEMBL118923	113000	0	None	-10000	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm020974x
	CHEMBL332091	113000	0	None	-10000	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm020974x
	11569515	77823	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	494	7	1	7	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(Cl)c(C(F)(F)F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210565	77823	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	494	7	1	7	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(Cl)c(C(F)(F)F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	135428630	81157	0	None	-2818	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	385	4	2	4	3.2	CCCN1C(=O)N2C[C@@H](C(C)C)N=C2c2[nH]c(C34CCC(O)(CC3)CC4)nc21	10.1021/jm060539t
	CHEMBL216269	81157	0	None	-2818	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	385	4	2	4	3.2	CCCN1C(=O)N2C[C@@H](C(C)C)N=C2c2[nH]c(C34CCC(O)(CC3)CC4)nc21	10.1021/jm060539t
	162663149	181357	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	4	2.2	CCC(C)OC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	CHEMBL4779925	181357	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	4	2.2	CCC(C)OC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	162667688	181887	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	4	2	4	2.3	CCCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.0c01431
	CHEMBL4786646	181887	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	4	2	4	2.3	CCCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.0c01431
	46880472	5986	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	305	4	2	4	2.9	O=C(Nc1ccc(-c2ccncc2)c(-c2cc[nH]n2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1080678	5986	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	305	4	2	4	2.9	O=C(Nc1ccc(-c2ccncc2)c(-c2cc[nH]n2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	10765059	102209	0	None	-354	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1770-2327Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1770-2327	ChEMBL	430	6	2	9	3.6	C=CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL304726	102209	0	None	-354	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1770-2327Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1770-2327	ChEMBL	430	6	2	9	3.6	C=CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	123683	3060	58	None	-95499	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1016/j.bmcl.2006.01.110
	422	3060	58	None	-95499	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1016/j.bmcl.2006.01.110
	CHEMBL119709	3060	58	None	-95499	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1016/j.bmcl.2006.01.110
	DB05511	3060	58	None	-95499	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1016/j.bmcl.2006.01.110
	123807	856	47	None	-13803	13	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/jm9905965
	374	856	47	None	-13803	13	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/jm9905965
	379	856	47	None	-13803	13	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/jm9905965
	CHEMBL284969	856	47	None	-13803	13	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/jm9905965
	9822747	118863	0	None	-16	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 157-268Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 157-268	ChEMBL	408	3	2	8	3.6	Cn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL344501	118863	0	None	-16	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 157-268Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 157-268	ChEMBL	408	3	2	8	3.6	Cn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	9822747	118863	0	None	-16	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 157-268Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 157-268	ChEMBL	408	3	2	8	3.6	Cn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL344501	118863	0	None	-16	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 157-268Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 157-268	ChEMBL	408	3	2	8	3.6	Cn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	2519	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2011.05.023
	407	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2011.05.023
	463	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2011.05.023
	CHEMBL113	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2011.05.023
	DB00201	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2011.05.023
	2519	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.0c00237
	407	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.0c00237
	463	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.0c00237
	CHEMBL113	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.0c00237
	DB00201	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.0c00237
	2519	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm4011669
	407	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm4011669
	463	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm4011669
	CHEMBL113	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm4011669
	DB00201	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm4011669
	459	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm001047y
	477	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm001047y
	5310960	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm001047y
	CHEMBL302765	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 1637-2582	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm001047y
	459	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm010818a
	477	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm010818a
	5310960	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm010818a
	CHEMBL302765	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm010818a
	459	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm0109614
	477	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm0109614
	5310960	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm0109614
	CHEMBL302765	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 1637-2582	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm0109614
	459	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm010570p
	477	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm010570p
	5310960	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm010570p
	CHEMBL302765	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 1640-2580	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1021/jm010570p
	15524546	103361	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	4	2	4	1.9	CCCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091707	103361	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	4	2	4	1.9	CCCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	21874662	188770	0	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	332	3	2	8	2.0	Nc1nc(-c2ccco2)c2nnn(Cc3ccc4[nH]ncc4c3)c2n1	10.1021/jm800961g
	CHEMBL512812	188770	0	None	-23	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	332	3	2	8	2.0	Nc1nc(-c2ccco2)c2nnn(Cc3ccc4[nH]ncc4c3)c2n1	10.1021/jm800961g
	15524546	103361	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	4	2	4	1.9	CCCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/ml400185v
	CHEMBL3091707	103361	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	4	2	4	1.9	CCCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/ml400185v
	135486084	13724	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	416	9	3	9	0.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)CCCN)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL1195913	13724	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	416	9	3	9	0.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)CCCN)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL555577	13724	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	416	9	3	9	0.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)CCCN)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	44390651	64424	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	511	9	1	10	3.9	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(C#N)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL181925	64424	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	511	9	1	10	3.9	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(C#N)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	135546658	115779	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	511	9	2	9	2.8	CC(C)Cn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)n(C)n3)[nH]c2n(CC(C)C)c1=O	10.1021/jm0309654
	CHEMBL33591	115779	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	511	9	2	9	2.8	CC(C)Cn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)n(C)n3)[nH]c2n(CC(C)C)c1=O	10.1021/jm0309654
	11995557	165295	0	None	-26	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	459	8	2	8	1.6	CCCn1c(=O)c2nc([C@]34CC[C@](C(=O)NCC(=O)OC)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	CHEMBL424908	165295	0	None	-26	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	459	8	2	8	1.6	CCCn1c(=O)c2nc([C@]34CC[C@](C(=O)NCC(=O)OC)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	46880511	6066	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	317	4	1	5	2.9	O=C(Nc1ccc(-c2ccncc2)c(-c2ccncn2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081042	6066	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	317	4	1	5	2.9	O=C(Nc1ccc(-c2ccncc2)c(-c2ccncn2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	44390587	63568	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(Cl)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL180588	63568	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(Cl)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	350741	162853	2	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	236	2	0	7	-1.0	CC(=O)Cn1c(=O)c2c(ncn2C)n(C)c1=O	10.1021/jm0104318
	CHEMBL419617	162853	2	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	236	2	0	7	-1.0	CC(=O)Cn1c(=O)c2c(ncn2C)n(C)c1=O	10.1021/jm0104318
	22266765	94140	0	None	30	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	460	8	1	10	2.7	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4noc(-c5ccccc5)n4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL252045	94140	0	None	30	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	460	8	1	10	2.7	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4noc(-c5ccccc5)n4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2008.01.008
	11952504	5930	0	None	34	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	263	2	1	5	2.7	c1coc(-c2nc3[nH]cnc3cc2-c2ccncn2)c1	10.1016/j.bmcl.2010.01.077
	CHEMBL1080327	5930	0	None	34	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	263	2	1	5	2.7	c1coc(-c2nc3[nH]cnc3cc2-c2ccncn2)c1	10.1016/j.bmcl.2010.01.077
	22266765	94140	0	None	30	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	460	8	1	10	2.7	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4noc(-c5ccccc5)n4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL252045	94140	0	None	30	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	460	8	1	10	2.7	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4noc(-c5ccccc5)n4)c3)nc2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11260448	134658	0	None	19	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(Cl)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL372084	134658	0	None	19	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(Cl)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	10029879	134659	0	None	61	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL372086	134659	0	None	61	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	21916408	158634	0	None	9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	378	5	1	7	2.0	CC(C)Cn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL409852	158634	0	None	9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	378	5	1	7	2.0	CC(C)Cn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O	10.1021/jm7014815
	21916406	160896	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	444	5	1	7	2.8	Cn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21	10.1021/jm7014815
	CHEMBL412747	160896	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	444	5	1	7	2.8	Cn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21	10.1021/jm7014815
	135444614	114226	0	None	-40	4	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells at 10000 nMInhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells at 10000 nM	ChEMBL	350	7	1	6	3.8	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(OCCC)cc3)nn12	10.1021/jm010570p
	CHEMBL333860	114226	0	None	-40	4	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells at 10000 nMInhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells at 10000 nM	ChEMBL	350	7	1	6	3.8	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(OCCC)cc3)nn12	10.1021/jm010570p
	11640595	139649	0	None	9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	7	2	6	3.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc21	10.1021/jm0506221
	CHEMBL380481	139649	0	None	9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	7	2	6	3.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc21	10.1021/jm0506221
	44450905	95561	0	None	48	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	604	10	1	6	6.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259760	95561	0	None	48	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	604	10	1	6	6.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	46228023	198218	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	382	6	0	8	2.4	C=CCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL594735	198218	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	382	6	0	8	2.4	C=CCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	46227952	199450	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	412	6	0	7	2.6	C=CCn1c(=O)c2c(nc(Cc3c(F)cccc3F)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL603209	199450	0	None	6	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	412	6	0	7	2.6	C=CCn1c(=O)c2c(nc(Cc3c(F)cccc3F)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	66893508	156542	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	505	9	1	9	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(OC)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4074473	156542	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	505	9	1	9	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(OC)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL5092037	213560	0	None	-2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(N)nc1-c1ccco1	10.1021/acs.jmedchem.1c01636
	11584826	72673	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	552	10	4	10	1.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)c4c(NC(=O)O)[nH]c(=O)n(C)c4=O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201026	72673	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	552	10	4	10	1.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)c4c(NC(=O)O)[nH]c(=O)n(C)c4=O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	46837562	10607	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	496	7	3	5	3.9	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	CHEMBL1170990	10607	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	496	7	3	5	3.9	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	136396061	158474	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	510	9	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5ccc(F)cc5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4096730	158474	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	510	9	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5ccc(F)cc5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	459	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1016/j.bmc.2011.11.037
	477	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1016/j.bmc.2011.11.037
	5310960	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1016/j.bmc.2011.11.037
	CHEMBL302765	2570	31	None	-389	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10.1016/j.bmc.2011.11.037
	135489505	139201	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	344	6	1	7	1.9	CCCn1c(=O)c2nc(-c3cc(C)nn3CC)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL379838	139201	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	344	6	1	7	1.9	CCCn1c(=O)c2nc(-c3cc(C)nn3CC)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	52947452	19101	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	558	9	2	5	4.7	CS(=O)(=O)c1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	CHEMBL1290543	19101	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	558	9	2	5	4.7	CS(=O)(=O)c1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	21874755	176308	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	336	4	2	8	1.8	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(C(=O)O)c3)c2n1	10.1021/jm800961g
	CHEMBL461656	176308	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	336	4	2	8	1.8	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(C(=O)O)c3)c2n1	10.1021/jm800961g
	380	1256	49	None	-17782	13	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10.1021/jm9905965
	657378	1256	49	None	-17782	13	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10.1021/jm9905965
	CHEMBL68738	1256	49	None	-17782	13	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10.1021/jm9905965
	11610747	72759	0	None	53	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	387	8	2	7	1.2	COCCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc21	10.1021/jm0506221
	CHEMBL201133	72759	0	None	53	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	387	8	2	7	1.2	COCCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc21	10.1021/jm0506221
	11510891	73047	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	459	6	2	8	2.1	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)Nc1ccc(C#N)cc1	10.1021/jm0506221
	CHEMBL201585	73047	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	459	6	2	8	2.1	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)Nc1ccc(C#N)cc1	10.1021/jm0506221
	162673131	182405	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	294	4	2	4	2.6	CC1=C(C(=O)OCC(C)C)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4793530	182405	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	294	4	2	4	2.6	CC1=C(C(=O)OCC(C)C)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	372	58	96	None	-2630	9	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10.1021/jm900413e
	8974	58	96	None	-2630	9	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10.1021/jm900413e
	CHEMBL285819	58	96	None	-2630	9	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10.1021/jm900413e
	44410555	168436	0	None	-15848	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	450	6	4	9	0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CCc4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL439335	168436	0	None	-15848	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	450	6	4	9	0.6	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CCc4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	44390545	62165	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(F)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL178172	62165	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(F)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	44390545	62165	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(F)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL178172	62165	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(F)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	156011975	176729	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	340	3	1	7	3.3	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cncs1	10.1021/acs.jmedchem.0c00564
	CHEMBL4636932	176729	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	340	3	1	7	3.3	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cncs1	10.1021/acs.jmedchem.0c00564
	10971806	56535	0	None	-7	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 184-250Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 184-250	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3cccc(OC)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164381	56535	0	None	-7	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 184-250Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 184-250	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3cccc(OC)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	145988962	166677	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	635	17	2	10	4.2	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCNC3CCCCC3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	CHEMBL4292514	166677	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	635	17	2	10	4.2	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCNC3CCCCC3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	14978313	102169	0	None	-4	5	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	204	1	1	5	-0.9	C#CCn1c(=O)c2[nH]cnc2n(C)c1=O	10.1021/jm0104318
	CHEMBL304455	102169	0	None	-4	5	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	204	1	1	5	-0.9	C#CCn1c(=O)c2[nH]cnc2n(C)c1=O	10.1021/jm0104318
	2867529	51598	8	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	236	2	2	4	1.1	COC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL1585743	51598	8	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	236	2	2	4	1.1	COC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	2867529	51598	8	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	236	2	2	4	1.1	COC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/ml400185v
	CHEMBL1585743	51598	8	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	236	2	2	4	1.1	COC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/ml400185v
	44307909	102577	1	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	219	1	0	7	-1.0	Cn1cnc2c1c(=O)n(CC#N)c(=O)n2C	10.1021/jm0104318
	CHEMBL307326	102577	1	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	219	1	0	7	-1.0	Cn1cnc2c1c(=O)n(CC#N)c(=O)n2C	10.1021/jm0104318
	CHEMBL5076095	212633	0	None	-32	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		CCNc1nc(-c2ccccc2)c(C#N)c(-c2ccc3c(c2)OCO3)n1	10.1021/acs.jmedchem.1c01636
	11560108	168490	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	387	6	1	8	1.2	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)c(OC)c1	10.1021/jm0506221
	CHEMBL439684	168490	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	387	6	1	8	1.2	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)c(OC)c1	10.1021/jm0506221
	127038753	136121	0	None	-165	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	466	7	4	13	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](C)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1039/C5MD00086F
	CHEMBL3740085	136121	0	None	-165	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	466	7	4	13	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](C)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1039/C5MD00086F
	11270783	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm900413e
	5615	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm900413e
	CHEMBL260933	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm900413e
	DB05936	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm900413e
	22266771	94174	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	417	6	2	8	2.4	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cc(-c5ccccc5)on4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL252272	94174	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	417	6	2	8	2.4	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cc(-c5ccccc5)on4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	10296638	36523	0	None	-4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 19-27Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 19-27	ChEMBL	434	4	2	7	4.8	COc1ccc(NC(=O)Nc2nc3ccc(Cl)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	CHEMBL144979	36523	0	None	-4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 19-27Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 19-27	ChEMBL	434	4	2	7	4.8	COc1ccc(NC(=O)Nc2nc3ccc(Cl)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	10296638	36523	0	None	-4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 19-27Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 19-27	ChEMBL	434	4	2	7	4.8	COc1ccc(NC(=O)Nc2nc3ccc(Cl)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm0109614
	CHEMBL144979	36523	0	None	-4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 19-27Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 19-27	ChEMBL	434	4	2	7	4.8	COc1ccc(NC(=O)Nc2nc3ccc(Cl)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm0109614
	11826924	118227	0	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	8	1	9	4.0	O=C(COc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL341777	118227	0	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	8	1	9	4.0	O=C(COc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	136042334	70802	0	None	33	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	490	8	2	9	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C)c(C)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955910	70802	0	None	33	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	490	8	2	9	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C)c(C)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	136042344	70811	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	551	8	2	9	4.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(Cl)cc(C(F)(F)F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955920	70811	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	551	8	2	9	4.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(Cl)cc(C(F)(F)F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	21958701	72631	0	None	4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	469	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cnn(CC(=O)Nc4ccccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200780	72631	0	None	4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	469	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cnn(CC(=O)Nc4ccccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11270783	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm7014815
	5615	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm7014815
	CHEMBL260933	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm7014815
	DB05936	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm7014815
	24827444	95884	0	None	14	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	365	5	1	8	1.6	CCCn1c(=O)c2[nH]c(-c3cnn(-c4cccnc4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL261526	95884	0	None	14	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	365	5	1	8	1.6	CCCn1c(=O)c2[nH]c(-c3cnn(-c4cccnc4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	21916394	160254	0	None	10	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	458	6	1	7	3.2	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21	10.1021/jm7014815
	CHEMBL411452	160254	0	None	10	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	458	6	1	7	3.2	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc21	10.1021/jm7014815
	49797774	10507	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	462	7	2	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(NS(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170137	10507	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	462	7	2	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(NS(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	10237267	10686	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	373	4	1	5	3.7	COc1ccc(N(C)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171898	10686	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	373	4	1	5	3.7	COc1ccc(N(C)C(C)=O)c2sc(NC(=O)c3ccc(F)cc3)nc12	10.1016/j.bmcl.2010.05.056
	9870396	138495	0	None	17	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	494	7	1	7	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)ccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL378598	138495	0	None	17	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	494	7	1	7	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)ccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11654461	138969	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(F)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL379474	138969	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(F)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11495984	72389	0	None	9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	444	5	2	6	2.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NC4CCc5ccccc54)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL199884	72389	0	None	9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	444	5	2	6	2.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NC4CCc5ccccc54)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11591823	74449	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	528	9	2	6	5.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL203148	74449	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	528	9	2	6	5.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	10164201	123251	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(F)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL362268	123251	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(F)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	743242	171478	12	None	-38	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	261	2	1	4	3.5	N#Cc1c(-c2ccco2)cc(-c2ccccc2)nc1N	10.1021/jm701594y
	CHEMBL447192	171478	12	None	-38	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	261	2	1	4	3.5	N#Cc1c(-c2ccco2)cc(-c2ccccc2)nc1N	10.1021/jm701594y
	853426	40723	11	None	-30	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PBS603 from human adenosine A2B receptor expressed in CHO cells after 2 hrs by scintillation countingDisplacement of [3H]PBS603 from human adenosine A2B receptor expressed in CHO cells after 2 hrs by scintillation counting	ChEMBL	264	2	2	5	2.5	Nc1nc(-c2ccccc2)nc(-c2ccccc2O)n1	10.1021/jm3003069
	CHEMBL1487093	40723	11	None	-30	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PBS603 from human adenosine A2B receptor expressed in CHO cells after 2 hrs by scintillation countingDisplacement of [3H]PBS603 from human adenosine A2B receptor expressed in CHO cells after 2 hrs by scintillation counting	ChEMBL	264	2	2	5	2.5	Nc1nc(-c2ccccc2)nc(-c2ccccc2O)n1	10.1021/jm3003069
	135428628	140919	0	None	-218	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	357	3	2	4	2.5	CCCN1C(=O)N2C[C@@H](C)N=C2c2[nH]c(C34CCC(O)(CC3)CC4)nc21	10.1021/jm060539t
	CHEMBL384279	140919	0	None	-218	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	357	3	2	4	2.5	CCCN1C(=O)N2C[C@@H](C)N=C2c2[nH]c(C34CCC(O)(CC3)CC4)nc21	10.1021/jm060539t
	9929470	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 60 mins by scintillation counting analysisDisplacement of [3H]-DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 60 mins by scintillation counting analysis	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/acs.jmedchem.5b00551
	CHEMBL324735	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 60 mins by scintillation counting analysisDisplacement of [3H]-DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 60 mins by scintillation counting analysis	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/acs.jmedchem.5b00551
	9929470	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm020974x
	CHEMBL324735	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm020974x
	9929470	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells by scintillation counterDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells by scintillation counter	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.ejmech.2015.12.019
	CHEMBL324735	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells by scintillation counterDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells by scintillation counter	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1016/j.ejmech.2015.12.019
	9929470	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 181-273Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 181-273	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL324735	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 181-273Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 181-273	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	9929470	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	CHEMBL324735	109971	0	None	-44	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	374	3	2	8	2.9	Cn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	135874432	95341	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	517	8	2	8	3.8	CCCn1c(=O)c2[nH]c(-c3nn(CC(=O)Nc4ccc(Cl)cc4)c(C)c3Cl)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL258755	95341	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	517	8	2	8	3.8	CCCn1c(=O)c2[nH]c(-c3nn(CC(=O)Nc4ccc(Cl)cc4)c(C)c3Cl)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	11058550	119613	0	None	-10	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 187-265Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 187-265	ChEMBL	404	4	2	9	2.9	COc1ccccc1NC(=O)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm0109614
	CHEMBL351211	119613	0	None	-10	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 187-265Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 187-265	ChEMBL	404	4	2	9	2.9	COc1ccccc1NC(=O)Nc1nc2nn(C)cc2c2nc(-c3ccco3)nn12	10.1021/jm0109614
	15578103	176202	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	1.3	Cc1ccc(-c2cc3c(c(=O)n(C)c(=O)n3C)n2O)cc1	10.1016/j.bmc.2008.09.067
	CHEMBL460617	176202	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	1.3	Cc1ccc(-c2cc3c(c(=O)n(C)c(=O)n3C)n2O)cc1	10.1016/j.bmc.2008.09.067
	71683092	89494	0	None	-3	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	340	5	1	5	3.2	COc1cccc(CCC(=O)Nc2nc3ccccc3c(=O)s2)c1	10.1021/jm400336x
	CHEMBL2380386	89494	0	None	-3	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	340	5	1	5	3.2	COc1cccc(CCC(=O)Nc2nc3ccccc3c(=O)s2)c1	10.1021/jm400336x
	21874687	172062	0	None	-15	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	293	3	1	8	1.5	Nc1nc(-c2ccco2)c2nnn(Cc3cccnc3)c2n1	10.1021/jm800961g
	CHEMBL449596	172062	0	None	-15	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	293	3	1	8	1.5	Nc1nc(-c2ccco2)c2nnn(Cc3cccnc3)c2n1	10.1021/jm800961g
	11026434	57175	0	None	-10	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	433	5	2	10	3.3	CCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165910	57175	0	None	-10	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	433	5	2	10	3.3	CCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	10601859	118632	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 183-278Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 183-278	ChEMBL	512	7	2	8	5.7	O=C(Nc1cccc(Cl)c1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL342906	118632	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 183-278Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 183-278	ChEMBL	512	7	2	8	5.7	O=C(Nc1cccc(Cl)c1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	10453097	196206	0	None	-20	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 183-278Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 183-278	ChEMBL	392	3	2	8	3.1	Cn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL572765	196206	0	None	-20	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 183-278Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 183-278	ChEMBL	392	3	2	8	3.1	Cn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	21874676	188863	0	None	-112	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	328	3	1	7	2.4	Nc1nc(-c2ccco2)c2nnn(Cc3ccc(F)cc3F)c2n1	10.1021/jm800961g
	CHEMBL513661	188863	0	None	-112	4	Human	6.7	pKi	=	6.7	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	328	3	1	7	2.4	Nc1nc(-c2ccco2)c2nnn(Cc3ccc(F)cc3F)c2n1	10.1021/jm800961g
	11157262	123110	0	None	-446	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	560	8	5	14	0.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Br)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL361925	123110	0	None	-446	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	560	8	5	14	0.2	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Br)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	9995603	99850	0	None	-17	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	311	5	1	4	3.0	CCCn1c(=O)c2[nH]c(-c3ccccc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL289413	99850	0	None	-17	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	311	5	1	4	3.0	CCCn1c(=O)c2[nH]c(-c3ccccc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	11213889	204721	0	None	-3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	485	8	2	9	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Oc4cccc([N+](=O)[O-])c4)cc3)nc2c1=O	10.1021/jm0310030
	CHEMBL8810	204721	0	None	-3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	485	8	2	9	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Oc4cccc([N+](=O)[O-])c4)cc3)nc2c1=O	10.1021/jm0310030
	10961304	75644	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	6	3	10	3.4	CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL20555	75644	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	6	3	10	3.4	CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL554955	75644	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	6	3	10	3.4	CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	137642862	157901	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	354	6	1	7	1.6	CC#CCn1cc(-c2nc3c([nH]2)c(=O)n(CCC)c(=O)n3CCC)cn1	10.1016/j.ejmech.2017.04.014
	CHEMBL4090649	157901	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	354	6	1	7	1.6	CC#CCn1cc(-c2nc3c([nH]2)c(=O)n(CCC)c(=O)n3CCC)cn1	10.1016/j.ejmech.2017.04.014
	137661874	158743	0	None	-60	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	405	4	2	7	3.0	COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(O)CC3)nc12	10.1021/acs.jmedchem.6b01584
	CHEMBL4099688	158743	0	None	-60	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	405	4	2	7	3.0	COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(O)CC3)nc12	10.1021/acs.jmedchem.6b01584
	66892501	156157	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	500	8	1	9	2.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C#N)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4070150	156157	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	500	8	1	9	2.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C#N)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	10310768	94116	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	466	7	2	9	2.8	CCCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251878	94116	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	466	7	2	9	2.8	CCCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	2690	888	59	None	-30	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 18-29Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 18-29	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm001047y
	384	888	59	None	-30	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 18-29Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 18-29	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm001047y
	CHEMBL16687	888	59	None	-30	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 18-29Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 18-29	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm001047y
	11952560	6245	1	None	20	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	263	2	1	5	2.7	c1coc(-c2nc3[nH]ncc3cc2-c2ccncn2)c1	10.1016/j.bmcl.2010.01.077
	CHEMBL1082002	6245	1	None	20	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	263	2	1	5	2.7	c1coc(-c2nc3[nH]ncc3cc2-c2ccncn2)c1	10.1016/j.bmcl.2010.01.077
	44588518	173585	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	317	5	2	6	2.3	CCCn1c(=O)c2[nH]c(-c3ccco3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL454700	173585	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	317	5	2	6	2.3	CCCn1c(=O)c2[nH]c(-c3ccco3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	136042338	70805	0	None	12	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	449	8	2	9	2.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955914	70805	0	None	12	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	449	8	2	9	2.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5ccccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	49797750	10638	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	437	6	1	9	2.9	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4cnnn4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171349	10638	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	437	6	1	9	2.9	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4cnnn4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	21874571	189261	0	None	-6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	325	3	2	8	1.8	Nc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c(F)c1	10.1021/jm800961g
	CHEMBL516800	189261	0	None	-6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	325	3	2	8	1.8	Nc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c(F)c1	10.1021/jm800961g
	156011786	176745	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cnoc1	10.1021/acs.jmedchem.0c00564
	CHEMBL4637204	176745	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cnoc1	10.1021/acs.jmedchem.0c00564
	2874872	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.5b01586
	CHEMBL1566489	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.5b01586
	2874872	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.7b00138
	CHEMBL1566489	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.7b00138
	2874872	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.0c01431
	CHEMBL1566489	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.0c01431
	2874872	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/ml400185v
	CHEMBL1566489	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/ml400185v
	2874872	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.9b01340
	CHEMBL1566489	49391	14	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	266	3	2	4	1.9	CCOC(=O)C1=C(C)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.9b01340
	168287172	191044	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	369	6	1	7	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(N=C=S)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5196082	191044	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	369	6	1	7	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(N=C=S)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	22282339	82677	1	None	-331	15	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] DPCPX from human adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from human adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	CHEMBL2181976	82677	1	None	-331	15	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] DPCPX from human adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from human adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	CHEMBL5084951	82677	1	None	-331	15	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] DPCPX from human adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assayDisplacement of [3H] DPCPX from human adenosine A2B receptor expressed in HEK293 cells incubated for 60 mins by radioligand binding assay	ChEMBL	386	4	1	5	5.1	Cc1cc(C)cc(-c2nc(NC(=O)c3cccnc3)sc2-c2ccncc2)c1	10.1021/acsmedchemlett.1c00685
	145960933	161002	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in cell membranes after 30 mins by beta-scintillation counting methodDisplacement of [3H]DPCPX from human A2B receptor expressed in cell membranes after 30 mins by beta-scintillation counting method	ChEMBL	271	2	2	2	3.5	O=C(Nc1nc2cccc(Cl)c2[nH]1)c1ccccc1	10.1021/acs.jmedchem.8b00204
	CHEMBL4128848	161002	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in cell membranes after 30 mins by beta-scintillation counting methodDisplacement of [3H]DPCPX from human A2B receptor expressed in cell membranes after 30 mins by beta-scintillation counting method	ChEMBL	271	2	2	2	3.5	O=C(Nc1nc2cccc(Cl)c2[nH]1)c1ccccc1	10.1021/acs.jmedchem.8b00204
	11493754	168185	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	336	3	1	7	0.9	Cn1c(=O)c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2n(C)c1=O	10.1021/jm051268+
	CHEMBL437301	168185	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	336	3	1	7	0.9	Cn1c(=O)c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2n(C)c1=O	10.1021/jm051268+
	2519	765	83	None	-1	12	Mouse	4.6	pKi	=	4.6	Binding	Displacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	407	765	83	None	-1	12	Mouse	4.6	pKi	=	4.6	Binding	Displacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	463	765	83	None	-1	12	Mouse	4.6	pKi	=	4.6	Binding	Displacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	CHEMBL113	765	83	None	-1	12	Mouse	4.6	pKi	=	4.6	Binding	Displacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	DB00201	765	83	None	-1	12	Mouse	4.6	pKi	=	4.6	Binding	Displacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	44459944	94391	6	None	1	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	266	3	0	8	-1.0	CC(=O)OCCn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	CHEMBL25373	94391	6	None	1	3	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	266	3	0	8	-1.0	CC(=O)OCCn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	11822168	201952	0	None	3	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	284	4	1	5	1.1	Cn1c(=O)n(CCCc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	CHEMBL67313	201952	0	None	3	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	284	4	1	5	1.1	Cn1c(=O)n(CCCc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	11702501	71141	0	None	-501	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	320	4	1	8	1.3	Cn1c(-n2nccn2)nc2c(N)nc(CCc3ccccc3)nc21	10.1021/jm058018d
	CHEMBL196259	71141	0	None	-501	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	320	4	1	8	1.3	Cn1c(-n2nccn2)nc2c(N)nc(CCc3ccccc3)nc21	10.1021/jm058018d
	155556575	173918	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	318	3	2	4	2.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4554893	173918	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	318	3	2	4	2.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	135443302	115896	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	331	5	2	8	0.7	CCCn1c(=O)c2nc(-c3cc(N)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33602	115896	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	331	5	2	8	0.7	CCCn1c(=O)c2nc(-c3cc(N)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	11826577	56985	0	None	-7	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 178-310Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 178-310	ChEMBL	456	4	2	8	4.4	CCn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165044	56985	0	None	-7	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 178-310Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 178-310	ChEMBL	456	4	2	8	4.4	CCn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	99619	201769	22	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	223	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCN)n(C)c1=O	10.1021/jm0104318
	CHEMBL66011	201769	22	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	223	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCN)n(C)c1=O	10.1021/jm0104318
	22375	201916	25	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	238	2	1	7	-1.5	Cn1cnc2c1c(=O)n(CC(=O)O)c(=O)n2C	10.1021/jm0104318
	CHEMBL67109	201916	25	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	238	2	1	7	-1.5	Cn1cnc2c1c(=O)n(CC(=O)O)c(=O)n2C	10.1021/jm0104318
	3286	3148	24	None	4	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	5311479	3148	24	None	4	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	CHEMBL8565	3148	24	None	4	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	155550704	173724	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	318	3	2	4	2.4	CC(C)OC(=O)C1=C(C(F)(F)F)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.9b01340
	CHEMBL4550201	173724	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	318	3	2	4	2.4	CC(C)OC(=O)C1=C(C(F)(F)F)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.9b01340
	44410556	140006	0	None	-10715	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	404	5	5	10	-1.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#C[C@H](C)O)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL381108	140006	0	None	-10715	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	404	5	5	10	-1.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#C[C@H](C)O)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	44452493	96013	0	None	-17	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	307	4	0	6	3.4	CCN(CC)c1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	CHEMBL262353	96013	0	None	-17	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	307	4	0	6	3.4	CCN(CC)c1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	135416058	488	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	442	488	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	CHEMBL2113342	488	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	135416058	488	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	442	488	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	CHEMBL2113342	488	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	10.1021/jm0309654
	16071896	57704	37	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human adenosine A2B receptor at 10 uMBinding affinity to human adenosine A2B receptor at 10 uM	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/jm201292w
	CHEMBL1672627	57704	37	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human adenosine A2B receptor at 10 uMBinding affinity to human adenosine A2B receptor at 10 uM	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/jm201292w
	10874051	83820	0	None	-7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	450	5	2	10	3.6	COc1ccc(NC(=O)Nc2nc3nn(C)c(SC)c3c3nc(-c4ccco4)nn23)cc1	10.1021/jm021023m
	CHEMBL22113	83820	0	None	-7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	450	5	2	10	3.6	COc1ccc(NC(=O)Nc2nc3nn(C)c(SC)c3c3nc(-c4ccco4)nn23)cc1	10.1021/jm021023m
	66894080	157573	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	479	7	1	8	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(F)c5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4087056	157573	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	479	7	1	8	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(F)c5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	21958761	168842	0	None	66	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	382	5	2	6	2.1	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL442434	168842	0	None	66	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	382	5	2	6	2.1	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	11659696	84818	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	317	4	1	8	2.7	c1coc(-c2nc(Nc3cncnc3)ncc2-c2ccncn2)c1	10.1021/jm061333v
	CHEMBL225972	84818	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	317	4	1	8	2.7	c1coc(-c2nc(Nc3cncnc3)ncc2-c2ccncn2)c1	10.1021/jm061333v
	16071896	57704	37	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672627	57704	37	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	44588474	174759	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	357	6	2	6	2.7	CCCn1c(=O)c2[nH]c(-c3ccc(OC)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457418	174759	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	357	6	2	6	2.7	CCCn1c(=O)c2[nH]c(-c3ccc(OC)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	44574254	172663	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	563	8	1	7	5.1	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL452454	172663	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	563	8	1	7	5.1	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	22266732	158789	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	514	7	1	10	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL410021	158789	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	514	7	1	10	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4noc(-c5ccc(C(F)(F)F)cc5)n4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	21874697	178003	0	None	-12	4	Human	7.6	pKi	=	7.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	328	3	1	7	2.4	Nc1nc(-c2ccco2)c2nnn(Cc3c(F)cccc3F)c2n1	10.1021/jm800961g
	CHEMBL467246	178003	0	None	-12	4	Human	7.6	pKi	=	7.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	328	3	1	7	2.4	Nc1nc(-c2ccco2)c2nnn(Cc3c(F)cccc3F)c2n1	10.1021/jm800961g
	10404217	119581	0	None	19	5	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	328	5	3	5	1.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(C(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL35094	119581	0	None	19	5	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	328	5	3	5	1.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(C(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	16071896	57704	37	None	-	1	Human	7.6	pKi	=	7.6	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1016/j.ejmech.2018.11.045
	CHEMBL1672627	57704	37	None	-	1	Human	7.6	pKi	=	7.6	Binding	Inhibition of human A2B adenosine receptorInhibition of human A2B adenosine receptor	ChEMBL	335	4	1	5	3.1	O=C(Nc1cnc(-c2ccncc2F)c(-c2cccnc2)n1)C1CC1	10.1016/j.ejmech.2018.11.045
	137634776	155422	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	288	3	2	5	1.6	CC1=C(C(=O)OC(C)C)C(c2ccco2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL4061502	155422	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	288	3	2	5	1.6	CC1=C(C(=O)OC(C)C)C(c2ccco2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	145975418	163289	0	None	7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	645	11	3	7	4.7	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4206556	163289	0	None	7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	645	11	3	7	4.7	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	11548714	72971	0	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	572	9	2	6	5.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201321	72971	0	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	572	9	2	6	5.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	11628044	74331	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	538	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)c(Br)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL203030	74331	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	538	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)c(Br)c2n(CCC)c1=O	10.1021/jm0506221
	44451199	156314	0	None	10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	557	9	1	7	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL407179	156314	0	None	10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	557	9	1	7	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	162668796	182133	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	262	4	2	3	2.5	CC1=C(C(=O)CC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4789729	182133	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	262	4	2	3	2.5	CC1=C(C(=O)CC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	11597118	76724	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	428	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(F)c4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL207482	76724	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	428	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(F)c4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	44410585	76951	0	None	-9999	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	478	8	4	9	1.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CCCCc4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL208311	76951	0	None	-9999	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	478	8	4	9	1.4	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CCCCc4ccccc4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	11761221	57834	0	None	-50	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 206-282Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 206-282	ChEMBL	402	5	2	8	3.8	CCCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL168018	57834	0	None	-50	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 206-282Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 206-282	ChEMBL	402	5	2	8	3.8	CCCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	18440425	196666	0	None	-15	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to adenosine A2B receptor (unknown origin)Binding affinity to adenosine A2B receptor (unknown origin)	ChEMBL	282	5	2	6	2.1	CCn1cnc2c(N)nc(NCCc3ccccc3)nc21	10.1039/C5MD00034C
	CHEMBL576447	196666	0	None	-15	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to adenosine A2B receptor (unknown origin)Binding affinity to adenosine A2B receptor (unknown origin)	ChEMBL	282	5	2	6	2.1	CCn1cnc2c(N)nc(NCCc3ccccc3)nc21	10.1039/C5MD00034C
	9953799	201674	2	None	-47	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 188-320Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 188-320	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL65271	201674	2	None	-47	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 188-320Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 188-320	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	9953799	201674	2	None	-47	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm010818a
	CHEMBL65271	201674	2	None	-47	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm010818a
	9953799	201674	2	None	-47	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 188-320Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 188-320	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL65271	201674	2	None	-47	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 188-320Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 188-320	ChEMBL	418	5	2	9	3.4	CCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11015003	56845	0	None	-9	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 211-287Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 211-287	ChEMBL	406	4	2	8	3.5	CCn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164685	56845	0	None	-9	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 211-287Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 211-287	ChEMBL	406	4	2	8	3.5	CCn1cc2c(nc(NC(=O)Nc3ccc(F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	44520980	198121	0	None	-977	4	Human	5.6	pKi	=	5.6	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	311	4	2	6	1.9	Cc1ccc(-c2cc(C(=O)NCc3cccn3C)nc(N)n2)o1	10.1016/j.bmc.2009.07.078
	CHEMBL594136	198121	0	None	-977	4	Human	5.6	pKi	=	5.6	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	311	4	2	6	1.9	Cc1ccc(-c2cc(C(=O)NCc3cccn3C)nc(N)n2)o1	10.1016/j.bmc.2009.07.078
	44449532	95728	0	None	-870	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	318	3	1	7	2.8	OC[C@@H]1CCCN1c1nc(-c2nccs2)c2sccc2n1	10.1016/j.bmcl.2008.03.076
	CHEMBL260718	95728	0	None	-870	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	318	3	1	7	2.8	OC[C@@H]1CCCN1c1nc(-c2nccs2)c2sccc2n1	10.1016/j.bmcl.2008.03.076
	9880392	188610	0	None	-30	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	326	3	1	7	2.7	Nc1nc(-c2cccs2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	CHEMBL511405	188610	0	None	-30	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	326	3	1	7	2.7	Nc1nc(-c2cccs2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	44410597	138678	0	None	-3235	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	496	7	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4ccc(OC)cc4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL378810	138678	0	None	-3235	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	496	7	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4ccc(OC)cc4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	168278363	190561	0	None	-169	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysis	ChEMBL	451	11	3	10	2.9	Nc1nc(-c2ccco2)c2cnn(Cc3cccc(OCCCCCCC(=O)NO)n3)c2n1	10.1016/j.ejmech.2022.114326
	CHEMBL5188801	190561	0	None	-169	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysis	ChEMBL	451	11	3	10	2.9	Nc1nc(-c2ccco2)c2cnn(Cc3cccc(OCCCCCCC(=O)NO)n3)c2n1	10.1016/j.ejmech.2022.114326
	11027412	29401	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	493	9	1	9	4.4	O=C(COc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL138593	29401	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	493	9	1	9	4.4	O=C(COc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	10895565	167876	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	445	8	1	9	3.8	CC(C)CCn1cc2c(nc(NC(=O)COc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	CHEMBL435022	167876	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	445	8	1	9	3.8	CC(C)CCn1cc2c(nc(NC(=O)COc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	16070337	57698	0	None	12	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	317	4	1	5	2.9	O=C(Nc1cnc(-c2ccncc2)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672621	57698	0	None	12	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	317	4	1	5	2.9	O=C(Nc1cnc(-c2ccncc2)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	136042332	70800	0	None	177	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	598	8	2	9	4.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C(F)(F)F)cc(C(F)(F)F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955908	70800	0	None	177	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	598	8	2	9	4.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C(F)(F)F)cc(C(F)(F)F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	22266769	156950	0	None	87	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	513	7	1	9	3.9	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cc(-c5ccc(C(F)(F)F)cc5)on4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL407969	156950	0	None	87	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	513	7	1	9	3.9	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cc(-c5ccc(C(F)(F)F)cc5)on4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	11690983	72280	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	452	6	2	7	2.4	COc1cc(OCC(=O)Nc2ccc(F)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	CHEMBL199485	72280	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	452	6	2	7	2.4	COc1cc(OCC(=O)Nc2ccc(F)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	11699025	73292	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	503	10	3	7	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(N)=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201791	73292	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	503	10	3	7	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(N)=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44451019	95408	0	None	27	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	7	1	7	2.8	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL259056	95408	0	None	27	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	7	1	7	2.8	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	44451020	158287	0	None	26	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	7	1	7	2.9	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL409481	158287	0	None	26	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	7	1	7	2.9	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CC)c1=O	10.1016/j.bmc.2008.01.002
	11511897	65756	0	None	8	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(OC)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL183915	65756	0	None	8	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(OC)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	1330	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0310030
	CHEMBL418333	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0310030
	CHEMBL435575	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0310030
	1330	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm060277v
	CHEMBL418333	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm060277v
	CHEMBL435575	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm060277v
	9887859	113000	0	None	-10000	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm020974x
	CHEMBL118923	113000	0	None	-10000	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm020974x
	CHEMBL332091	113000	0	None	-10000	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from Human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	375	3	2	9	2.3	Cn1cc2c(nc(NC(=O)Nc3ccncc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm020974x
	135874433	95632	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	561	8	2	8	3.9	CCCn1c(=O)c2[nH]c(-c3nn(CC(=O)Nc4ccc(Cl)cc4)c(C)c3Br)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL260153	95632	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	561	8	2	8	3.9	CCCn1c(=O)c2[nH]c(-c3nn(CC(=O)Nc4ccc(Cl)cc4)c(C)c3Br)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	11574428	137776	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	379	5	3	8	-1.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)NCCO)cc3)[nH]c2n(C)c1=O	10.1021/jm060277v
	CHEMBL377106	137776	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	379	5	3	8	-1.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)NCCO)cc3)[nH]c2n(C)c1=O	10.1021/jm060277v
	1330	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm011049y
	CHEMBL418333	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm011049y
	CHEMBL435575	162655	37	None	-1	6	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	392	6	2	7	1.6	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm011049y
	11811544	56894	0	None	-10	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 213-296Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 213-296	ChEMBL	404	4	2	9	2.9	COc1cccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)c1	10.1021/jm0109614
	CHEMBL164992	56894	0	None	-10	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 213-296Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 213-296	ChEMBL	404	4	2	9	2.9	COc1cccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)c1	10.1021/jm0109614
	44452434	160080	0	None	-3	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	369	4	1	6	3.7	O=C(Cc1ccccc1)Nc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	CHEMBL411319	160080	0	None	-3	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	369	4	1	6	3.7	O=C(Cc1ccccc1)Nc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	44452455	160283	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	293	2	1	6	2.5	CC(=O)Nc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	CHEMBL411482	160283	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	293	2	1	6	2.5	CC(=O)Nc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	44452431	96150	0	None	-12	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	345	3	1	7	3.4	O=C(Nc1nc2ccccc2n2nc(-c3ccco3)nc12)c1ccco1	10.1016/j.bmc.2007.10.103
	CHEMBL263370	96150	0	None	-12	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	345	3	1	7	3.4	O=C(Nc1nc2ccccc2n2nc(-c3ccco3)nc12)c1ccco1	10.1016/j.bmc.2007.10.103
	24827998	138455	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	249	3	1	4	1.7	CCOC(=O)C1=C(C)NC(=O)CC1c1ccco1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785517	138455	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	249	3	1	4	1.7	CCOC(=O)C1=C(C)NC(=O)CC1c1ccco1	10.1021/acs.jmedchem.5b01586
	9857698	176307	0	None	-85	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	306	3	1	7	2.4	Cc1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	CHEMBL461651	176307	0	None	-85	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	306	3	1	7	2.4	Cc1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	21958541	62652	0	None	19	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(C(F)(F)F)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL178662	62652	0	None	19	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(C(F)(F)F)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	176408	3488	79	None	-407	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/acs.jmedchem.1c01155
	403	3488	79	None	-407	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/acs.jmedchem.1c01155
	431	3488	79	None	-407	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/acs.jmedchem.1c01155
	CHEMBL17127	3488	79	None	-407	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis	ChEMBL	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	10.1021/acs.jmedchem.1c01155
	372	58	96	None	-2630	9	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10.1021/jm900413e
	8974	58	96	None	-2630	9	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10.1021/jm900413e
	CHEMBL285819	58	96	None	-2630	9	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10.1021/jm900413e
	72546539	103363	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	278	5	2	4	2.3	CCCC1=C(C(=O)OCC)C(c2ccco2)NC(=O)N1	10.1021/ml400185v
	CHEMBL3091711	103363	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	278	5	2	4	2.3	CCCC1=C(C(=O)OCC)C(c2ccco2)NC(=O)N1	10.1021/ml400185v
	9857266	176397	0	None	-21	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	293	3	1	8	1.5	Nc1nc(-c2ccco2)c2nnn(Cc3ccccn3)c2n1	10.1021/jm800961g
	CHEMBL462501	176397	0	None	-21	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	293	3	1	8	1.5	Nc1nc(-c2ccco2)c2nnn(Cc3ccccn3)c2n1	10.1021/jm800961g
	10155413	176305	0	None	-117	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	360	3	1	7	3.1	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(C(F)(F)F)c3)c2n1	10.1021/jm800961g
	CHEMBL461649	176305	0	None	-117	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	360	3	1	7	3.1	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(C(F)(F)F)c3)c2n1	10.1021/jm800961g
	10051061	160978	0	None	-10	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	485	8	2	9	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Oc4ccc([N+](=O)[O-])cc4)cc3)nc2c1=O	10.1021/jm0310030
	CHEMBL412854	160978	0	None	-10	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	485	8	2	9	2.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Oc4ccc([N+](=O)[O-])cc4)cc3)nc2c1=O	10.1021/jm0310030
	11071159	99036	0	None	12	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	502	5	2	11	2.7	COc1ccc(NC(=O)Nc2nc3nn(C)c(N4CCN(C)CC4)c3c3nc(-c4ccco4)nn23)cc1	10.1021/jm021023m
	CHEMBL283319	99036	0	None	12	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	502	5	2	11	2.7	COc1ccc(NC(=O)Nc2nc3nn(C)c(N4CCN(C)CC4)c3c3nc(-c4ccco4)nn23)cc1	10.1021/jm021023m
	53321372	57706	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	353	4	1	5	3.2	O=C(Nc1cnc(-c2c(F)cncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672629	57706	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	353	4	1	5	3.2	O=C(Nc1cnc(-c2c(F)cncc2F)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	21958512	165962	0	None	8	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	6	1	7	2.3	CCCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL427911	165962	0	None	8	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	6	1	7	2.3	CCCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	11121771	99866	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	354	5	2	6	1.7	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(/C=C/C(=O)OC)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL289516	99866	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	354	5	2	6	1.7	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(/C=C/C(=O)OC)cc3)nc2c1=O	10.1021/jm011049y
	11676986	165190	0	None	11	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	461	9	2	7	3.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccn4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL424671	165190	0	None	11	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	461	9	2	7	3.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccn4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	46233378	198644	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	370	5	0	8	2.2	CCn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2cccs2)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL597559	198644	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	370	5	0	8	2.2	CCn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2cccs2)c1=O	10.1016/j.bmc.2010.01.028
	16122818	57543	16	None	-44	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-MRS1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-MRS1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	353	4	2	4	4.0	CC(C)(C)CC(=O)Nc1c(F)cc(C(=O)Nc2nccs2)cc1F	10.1021/jm1008659
	CHEMBL1671936	57543	16	None	-44	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-MRS1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-MRS1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	353	4	2	4	4.0	CC(C)(C)CC(=O)Nc1c(F)cc(C(=O)Nc2nccs2)cc1F	10.1021/jm1008659
	9801343	111919	0	None	-41	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 226-301Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 226-301	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	CHEMBL329791	111919	0	None	-41	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 226-301Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 226-301	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	9801343	111919	0	None	-41	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm010818a
	CHEMBL329791	111919	0	None	-41	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm010818a
	9801343	111919	0	None	-41	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 226-301Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 226-301	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm0109614
	CHEMBL329791	111919	0	None	-41	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 226-301Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 226-301	ChEMBL	404	4	2	9	2.9	COc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm0109614
	377	2707	47	None	-1479	15	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	425	2707	47	None	-1479	15	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	448222	2707	47	None	-1479	15	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	CHEMBL464859	2707	47	None	-1479	15	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	11641051	168275	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	454	9	2	7	2.2	COCCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)NC4CCCC4)cc3)cc21	10.1021/jm0506221
	CHEMBL438071	168275	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	454	9	2	7	2.2	COCCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)NC4CCCC4)cc3)cc21	10.1021/jm0506221
	44410402	75752	0	None	-12882	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	444	5	5	10	-0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC4(O)CCCC4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL205768	75752	0	None	-12882	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	444	5	5	10	-0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC4(O)CCCC4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	5604	3304	31	None	-1995	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	10.1039/C8MD00070K
	64627	3304	31	None	-1995	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	10.1039/C8MD00070K
	CHEMBL52333	3304	31	None	-1995	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	10.1039/C8MD00070K
	DB05360	3304	31	None	-1995	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	10.1039/C8MD00070K
	11674882	73035	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	359	5	2	7	0.7	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)O	10.1021/jm0506221
	CHEMBL201547	73035	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	359	5	2	7	0.7	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)O	10.1021/jm0506221
	46228057	199636	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	366	5	1	7	1.8	C#CCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL604283	199636	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	366	5	1	7	1.8	C#CCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	11544894	95916	0	None	7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	354	3	1	7	1.0	Cn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL261722	95916	0	None	7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	354	3	1	7	1.0	Cn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	44450517	157778	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	390	6	1	7	2.2	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc21	10.1021/jm7014815
	CHEMBL408936	157778	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	390	6	1	7	2.2	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc21	10.1021/jm7014815
	11544894	95916	0	None	7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	354	3	1	7	1.0	Cn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm051268+
	CHEMBL261722	95916	0	None	7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	354	3	1	7	1.0	Cn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm051268+
	155537221	171700	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	377	3	1	6	4.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1016/j.ejmech.2021.113907
	CHEMBL4474714	171700	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	377	3	1	6	4.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1016/j.ejmech.2021.113907
	155537221	171700	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4474714	171700	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	11710918	138264	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	393	7	4	7	-0.2	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCCO)cc3)nc2c1=O	10.1021/jm060277v
	CHEMBL378102	138264	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	393	7	4	7	-0.2	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCCO)cc3)nc2c1=O	10.1021/jm060277v
	11713242	72235	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199326	72235	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	11590097	74124	0	None	8	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	6	2	6	2.5	CC(NC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)c1ccccc1	10.1021/jm0506221
	CHEMBL202828	74124	0	None	8	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	6	2	6	2.5	CC(NC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)c1ccccc1	10.1021/jm0506221
	11548192	165434	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	524	10	2	7	4.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL425395	165434	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	524	10	2	7	4.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	44451489	158516	0	None	22	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	489	5	2	8	1.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(O)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL409725	158516	0	None	22	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	489	5	2	8	1.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(O)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	46227973	198051	0	None	14	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	400	7	0	9	1.8	COCCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL593572	198051	0	None	14	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	400	7	0	9	1.8	COCCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	145964230	163448	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	461	10	3	6	2.6	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4208432	163448	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	461	10	3	6	2.6	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	9901171	176240	0	None	-107	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	307	3	2	8	1.7	Nc1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	CHEMBL461008	176240	0	None	-107	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	307	3	2	8	1.7	Nc1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	2153	3728	108	None	-21	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.02.014
	2620	3728	108	None	-21	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.02.014
	413	3728	108	None	-21	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.02.014
	CHEMBL190	3728	108	None	-21	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.02.014
	DB00277	3728	108	None	-21	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.02.014
	9858578	188389	0	None	-31	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	327	3	1	8	2.1	Nc1nc(-c2nccs2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	CHEMBL508558	188389	0	None	-31	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	327	3	1	8	2.1	Nc1nc(-c2nccs2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	10256007	122401	0	None	-10	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	516	8	5	14	0.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Cl)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL360646	122401	0	None	-10	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	516	8	5	14	0.1	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(Cl)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	145979285	166116	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	604	16	1	11	3.2	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCn3ccnc3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	CHEMBL4282002	166116	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	604	16	1	11	3.2	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCn3ccnc3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	46228025	198255	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	416	8	1	8	2.9	CCSCCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL594970	198255	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	416	8	1	8	2.9	CCSCCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	127034216	138419	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	287	3	1	6	2.7	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2ccnc2N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785215	138419	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	287	3	1	6	2.7	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2ccnc2N1	10.1021/acs.jmedchem.5b01586
	69550	202394	82	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	238	2	1	7	-1.5	Cn1c(=O)c2c(ncn2CC(=O)O)n(C)c1=O	10.1021/jm0104318
	CHEMBL70246	202394	82	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	238	2	1	7	-1.5	Cn1c(=O)c2c(ncn2CC(=O)O)n(C)c1=O	10.1021/jm0104318
	156018530	177210	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	354	3	1	7	3.7	CC1=C(C(=O)OC(C)C)C(c2cnsc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4643403	177210	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	354	3	1	7	3.7	CC1=C(C(=O)OC(C)C)C(c2cnsc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	44390444	64587	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(OC)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL182259	64587	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(OC)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	70689262	77608	0	None	-1202	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	496	8	4	14	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](C)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL2096798	77608	0	None	-1202	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	496	8	4	14	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](C)Cc5ccc(OC)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	135493281	109125	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	483	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(Cl)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32225	109125	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	483	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(Cl)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135493281	109125	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	483	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(Cl)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32225	109125	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	483	8	2	8	2.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(Cl)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	21958525	155006	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	432	5	2	6	3.0	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL404348	155006	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	432	5	2	6	3.0	CC(C)Cn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	16720106	168308	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	346	4	1	8	2.6	Cn1cc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)ccc1=O	10.1021/jm061333v
	CHEMBL438306	168308	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	346	4	1	8	2.6	Cn1cc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)ccc1=O	10.1021/jm061333v
	10906943	116017	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	7	1	8	5.1	CC(C)CCn1cc2c(nc(NC(=O)Cc3cccc4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	CHEMBL336217	116017	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	7	1	8	5.1	CC(C)CCn1cc2c(nc(NC(=O)Cc3cccc4ccccc34)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	46880372	5431	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	3	1	3	3.5	O=C(Nc1ccc(Br)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1076562	5431	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	3	1	3	3.5	O=C(Nc1ccc(Br)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	135874429	95298	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	483	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4cccc(Cl)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL258473	95298	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	483	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4cccc(Cl)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	135874414	95795	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	575	8	2	8	3.1	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(I)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL261027	95795	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	575	8	2	8	3.1	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(I)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	176407	4069	76	None	-34	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human A2B receptor expressed in HEK-293 cell membranesDisplacement of [3H]ZM-241385 from human A2B receptor expressed in HEK-293 cell membranes	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.ejmech.2015.12.019
	405	4069	76	None	-34	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human A2B receptor expressed in HEK-293 cell membranesDisplacement of [3H]ZM-241385 from human A2B receptor expressed in HEK-293 cell membranes	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.ejmech.2015.12.019
	CHEMBL113142	4069	76	None	-34	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human A2B receptor expressed in HEK-293 cell membranesDisplacement of [3H]ZM-241385 from human A2B receptor expressed in HEK-293 cell membranes	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.ejmech.2015.12.019
	DB08770	4069	76	None	-34	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM-241385 from human A2B receptor expressed in HEK-293 cell membranesDisplacement of [3H]ZM-241385 from human A2B receptor expressed in HEK-293 cell membranes	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1016/j.ejmech.2015.12.019
	50925499	19025	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	523	9	2	5	5.9	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290101	19025	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	523	9	2	5	5.9	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	52943652	19041	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	509	9	2	5	5.7	C[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290210	19041	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	509	9	2	5	5.7	C[C@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	11589625	77847	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210649	77847	0	None	-1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	410	7	1	7	2.8	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11677252	73499	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	475	10	2	7	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccncc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201895	73499	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	475	10	2	7	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccncc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11386134	67114	0	None	-1995	5	Human	4.6	pKi	=	4.6	Binding	Selectivity for recombinant human adenosine A2b receptorSelectivity for recombinant human adenosine A2b receptor	ChEMBL	482	4	1	11	2.1	Cn1nc(C(F)(F)F)c(CN2CCN(c3nc(N)n4nc(-c5ccco5)nc4n3)CC2)c1Cl	10.1021/jm0498405
	CHEMBL189192	67114	0	None	-1995	5	Human	4.6	pKi	=	4.6	Binding	Selectivity for recombinant human adenosine A2b receptorSelectivity for recombinant human adenosine A2b receptor	ChEMBL	482	4	1	11	2.1	Cn1nc(C(F)(F)F)c(CN2CCN(c3nc(N)n4nc(-c5ccco5)nc4n3)CC2)c1Cl	10.1021/jm0498405
	46233348	198604	0	None	6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	364	5	0	7	2.1	CCn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2ccccc2)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL597355	198604	0	None	6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	364	5	0	7	2.1	CCn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2ccccc2)c1=O	10.1016/j.bmc.2010.01.028
	21874786	189237	0	None	-93	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	306	3	1	7	2.4	Cc1ccccc1Cn1nnc2c(-c3ccco3)nc(N)nc21	10.1021/jm800961g
	CHEMBL516611	189237	0	None	-93	4	Human	6.6	pKi	=	6.6	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	306	3	1	7	2.4	Cc1ccccc1Cn1nnc2c(-c3ccco3)nc(N)nc21	10.1021/jm800961g
	162676957	182944	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	306	4	2	4	2.7	CC1=C(C(=O)OCC2CCC2)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4800019	182944	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	306	4	2	4	2.7	CC1=C(C(=O)OCC2CCC2)C(c2cccs2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	10993916	56846	0	None	-12	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 235-347Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 235-347	ChEMBL	442	3	2	8	3.9	Cn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164686	56846	0	None	-12	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 235-347Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 235-347	ChEMBL	442	3	2	8	3.9	Cn1cc2c(nc(NC(=O)Nc3ccc(C(F)(F)F)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	750351	188703	13	None	5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	271	1	2	5	0.9	Cn1c(=O)c2[nH]c(-c3ccccc3)c(O)c2n(C)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL512216	188703	13	None	5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	271	1	2	5	0.9	Cn1c(=O)c2[nH]c(-c3ccccc3)c(O)c2n(C)c1=O	10.1016/j.bmc.2008.09.067
	11660427	73036	0	None	6	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	357	5	1	7	1.2	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1021/jm0506221
	CHEMBL201548	73036	0	None	6	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	357	5	1	7	1.2	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1021/jm0506221
	12391837	9621	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	299	2	1	6	0.7	CN(C)c1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1021/jm0104318
	CHEMBL11332	9621	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	299	2	1	6	0.7	CN(C)c1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1021/jm0104318
	25027416	64133	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	281	2	2	4	2.8	O=C(Nc1ccc(O)cc1)c1coc2ccccc2c1=O	10.1016/j.ejmech.2012.05.033
	CHEMBL1814064	64133	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	281	2	2	4	2.8	O=C(Nc1ccc(O)cc1)c1coc2ccccc2c1=O	10.1016/j.ejmech.2012.05.033
	44236566	158421	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	484	6	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccccc4C(F)(F)F)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4096238	158421	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	484	6	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccccc4C(F)(F)F)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	16070220	57703	0	None	3	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	4	1	6	2.5	O=C(Nc1cnc(-c2ccncn2)c(-c2ccco2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672626	57703	0	None	3	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	4	1	6	2.5	O=C(Nc1cnc(-c2ccncn2)c(-c2ccco2)n1)C1CC1	10.1021/ml100249e
	11532717	77417	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	460	7	1	7	3.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(Cl)ccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL209174	77417	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	460	7	1	7	3.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(Cl)ccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	155524137	170305	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1016/j.ejmech.2021.113907
	CHEMBL4454378	170305	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1016/j.ejmech.2021.113907
	127030364	138596	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL3787034	138596	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	127030364	138596	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3787034	138596	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.5b01586
	127030364	138596	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL3787034	138596	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	156017721	177260	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2cnoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4644103	177260	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2cnoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	155524137	170305	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4454378	170305	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL5082973	213052	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(Nc2ccccc2)nc1-c1cccnc1	10.1021/acs.jmedchem.1c01636
	127033325	138462	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccsc1	10.1021/acs.jmedchem.0c00564
	CHEMBL3785618	138462	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccsc1	10.1021/acs.jmedchem.0c00564
	127033325	138462	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccsc1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785618	138462	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccsc1	10.1021/acs.jmedchem.5b01586
	127033325	138462	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccsc1	10.1021/acs.jmedchem.9b01340
	CHEMBL3785618	138462	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccsc1	10.1021/acs.jmedchem.9b01340
	10046145	2635	11	None	-575	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	10.1021/jm4011669
	5610	2635	11	None	-575	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	10.1021/jm4011669
	CHEMBL413079	2635	11	None	-575	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	10.1021/jm4011669
	52946159	19082	0	None	4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	493	9	2	4	5.7	O=C(CCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290435	19082	0	None	4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	493	9	2	4	5.7	O=C(CCc1ccccc1)NCc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	11995649	140993	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	473	8	1	8	1.9	CCCn1c(=O)c2nc([C@]34CC[C@](C(=O)N(C)CC(=O)OC)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	CHEMBL384705	140993	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	473	8	1	8	1.9	CCCn1c(=O)c2nc([C@]34CC[C@](C(=O)N(C)CC(=O)OC)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	44417669	141109	0	None	-37	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	356	5	1	5	2.8	CCCn1c(=O)c2nc(C34CC5CC(C3)C(C5)C4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	CHEMBL385372	141109	0	None	-37	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	356	5	1	5	2.8	CCCn1c(=O)c2nc(C34CC5CC(C3)C(C5)C4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	11037972	57140	0	None	-25	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 261-336Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 261-336	ChEMBL	466	4	2	8	4.2	CCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165600	57140	0	None	-25	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 261-336Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 261-336	ChEMBL	466	4	2	8	4.2	CCn1cc2c(nc(NC(=O)Nc3ccc(Br)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	5604	3304	31	None	-1995	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	10.1016/j.ejmech.2019.111879
	64627	3304	31	None	-1995	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	10.1016/j.ejmech.2019.111879
	CHEMBL52333	3304	31	None	-1995	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	10.1016/j.ejmech.2019.111879
	DB05360	3304	31	None	-1995	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	10.1016/j.ejmech.2019.111879
	18171064	103360	4	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	280	3	1	4	2.3	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccsc1	10.1021/ml400185v
	CHEMBL3091706	103360	4	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	280	3	1	4	2.3	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccsc1	10.1021/ml400185v
	145979018	166058	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	609	15	1	11	2.2	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN3CCOCC3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	CHEMBL4280776	166058	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	609	15	1	11	2.2	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN3CCOCC3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	57429618	158520	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	392	4	2	6	1.9	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4097296	158520	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	392	4	2	6	1.9	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	69029783	155774	0	None	3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	570	9	1	8	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4065717	155774	0	None	3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	570	9	1	8	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44446477	155007	0	None	331	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	430	5	2	6	2.8	O=c1[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	CHEMBL404349	155007	0	None	331	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	430	5	2	6	2.8	O=c1[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	44451330	95724	0	None	53	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	5	1	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260693	95724	0	None	53	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	5	1	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	11952564	5954	0	None	26	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	279	2	2	5	2.0	O=c1[nH][nH]c2nc(-c3ccco3)c(-c3ccncn3)cc12	10.1016/j.bmcl.2010.01.077
	CHEMBL1080497	5954	0	None	26	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	279	2	2	5	2.0	O=c1[nH][nH]c2nc(-c3ccco3)c(-c3ccncn3)cc12	10.1016/j.bmcl.2010.01.077
	16072022	57692	0	None	5	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	320	4	1	5	3.5	O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)C1CCC1	10.1021/ml100249e
	CHEMBL1672615	57692	0	None	5	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	320	4	1	5	3.5	O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)C1CCC1	10.1021/ml100249e
	45271361	193689	0	None	6	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	495	10	2	8	2.8	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL551904	193689	0	None	6	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	495	10	2	8	2.8	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	45269707	194389	0	None	12	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	477	10	2	8	2.6	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL560624	194389	0	None	12	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	477	10	2	8	2.6	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11568001	72270	0	None	3	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	422	5	2	6	2.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL199446	72270	0	None	3	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	422	5	2	6	2.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44185936	184942	0	None	12	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	522	8	3	7	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL486282	184942	0	None	12	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	522	8	3	7	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	449	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	453	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	6603931	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	CHEMBL273807	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/acs.jmedchem.9b00071
	11583705	73236	0	None	28	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	474	10	2	6	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201773	73236	0	None	28	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	474	10	2	6	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11503616	74332	0	None	41	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	463	8	2	8	2.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC)nc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL203037	74332	0	None	41	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	463	8	2	8	2.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC)nc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	9912816	97969	0	None	1	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	475	10	2	7	3.1	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL275605	97969	0	None	1	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	475	10	2	7	3.1	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	11511593	140607	0	None	10	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	494	9	2	6	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL382764	140607	0	None	10	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	494	9	2	6	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44574168	178147	0	None	5	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	394	4	2	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccco4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL468506	178147	0	None	5	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	394	4	2	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccco4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	155531727	171090	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	512	6	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5F)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4466211	171090	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	512	6	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5F)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	11627336	139830	0	None	18	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	492	9	2	6	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL380847	139830	0	None	18	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	492	9	2	6	4.5	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	168287172	191044	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	369	6	1	7	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(N=C=S)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5196082	191044	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	369	6	1	7	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(N=C=S)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	145970075	164240	0	None	8	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	475	11	3	6	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4218460	164240	0	None	8	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	475	11	3	6	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	11677313	72933	0	None	3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	478	9	2	6	4.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201281	72933	0	None	3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	478	9	2	6	4.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44451306	95805	0	None	117	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	5	1	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL261056	95805	0	None	117	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	5	1	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	449	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	Binding affinity to mouse adenosine A2B receptorBinding affinity to mouse adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	453	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	Binding affinity to mouse adenosine A2B receptorBinding affinity to mouse adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	6603931	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	Binding affinity to mouse adenosine A2B receptorBinding affinity to mouse adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	CHEMBL273807	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	Binding affinity to mouse adenosine A2B receptorBinding affinity to mouse adenosine A2B receptor	ChEMBL	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10.1021/jm900413e
	11642035	73182	0	None	7	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	6	2	7	3.0	COc1cc(OCC(=O)Nc2ccc(Br)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	CHEMBL201750	73182	0	None	7	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	6	2	7	3.0	COc1cc(OCC(=O)Nc2ccc(Br)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	11642035	73182	0	None	7	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	512	6	2	7	3.0	COc1cc(OCC(=O)Nc2ccc(Br)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	CHEMBL201750	73182	0	None	7	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	512	6	2	7	3.0	COc1cc(OCC(=O)Nc2ccc(Br)cc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	44451305	159786	0	None	33	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	551	5	1	7	2.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(Br)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL411075	159786	0	None	33	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	551	5	1	7	2.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(Br)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	11223	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.0c00564
	17198004	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.0c00564
	CHEMBL3787197	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.0c00564
	11223	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.5b01586
	17198004	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.5b01586
	CHEMBL3787197	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.5b01586
	11223	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.0c01431
	17198004	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.0c01431
	CHEMBL3787197	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.0c01431
	11223	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.9b01340
	17198004	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.9b01340
	CHEMBL3787197	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	10.1021/acs.jmedchem.9b01340
	57429605	156629	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	488	8	1	9	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(=O)OCC)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4075650	156629	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	488	8	1	9	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(=O)OCC)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	16072020	57690	0	None	12	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	294	4	1	5	3.1	CCC(=O)Nc1cnc(-c2ccncc2)c(-c2ccco2)n1	10.1021/ml100249e
	CHEMBL1672613	57690	0	None	12	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	294	4	1	5	3.1	CCC(=O)Nc1cnc(-c2ccncc2)c(-c2ccco2)n1	10.1021/ml100249e
	136042339	70806	0	None	19	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	483	8	2	9	3.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955915	70806	0	None	19	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	483	8	2	9	3.5	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	11590411	168514	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	446	6	2	7	2.5	CC(=O)c1ccc(NC(=O)COc2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)cc1	10.1021/jm0506221
	CHEMBL439868	168514	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	446	6	2	7	2.5	CC(=O)c1ccc(NC(=O)COc2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)cc1	10.1021/jm0506221
	46837705	10509	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	496	7	3	5	3.9	CCCn1c(=O)[nH]c2cc(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)[nH]c2c1=O	10.1016/j.ejmech.2010.03.011
	CHEMBL1170167	10509	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	496	7	3	5	3.9	CCCn1c(=O)[nH]c2cc(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)[nH]c2c1=O	10.1016/j.ejmech.2010.03.011
	155549264	173238	0	None	26	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	544	6	3	8	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(O)c(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4538468	173238	0	None	26	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	544	6	3	8	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(O)c(Cl)c5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	11605883	79527	5	None	42	6	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL212625	79527	5	None	42	6	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	57429602	156685	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4076435	156685	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	57988777	156537	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	529	8	1	8	4.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4074412	156537	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	529	8	1	8	4.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	50940969	56940	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in human HEK293 cells at 1 uM incubated for 30 mins by fluorescence polarization binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in human HEK293 cells at 1 uM incubated for 30 mins by fluorescence polarization binding assay	ChEMBL	363	6	1	5	4.2	CCC(=O)Nc1cc(-c2ccc(OC)cc2)nc(-c2ccc(OC)cc2)n1	10.1021/acsmedchemlett.1c00598
	CHEMBL1650356	56940	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in human HEK293 cells at 1 uM incubated for 30 mins by fluorescence polarization binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in human HEK293 cells at 1 uM incubated for 30 mins by fluorescence polarization binding assay	ChEMBL	363	6	1	5	4.2	CCC(=O)Nc1cc(-c2ccc(OC)cc2)nc(-c2ccc(OC)cc2)n1	10.1021/acsmedchemlett.1c00598
	11605883	79527	5	None	42	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm060277v
	CHEMBL212625	79527	5	None	42	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm060277v
	11525283	79240	0	None	2	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	453	8	3	6	2.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCCc4ccccc4)cc3)nc2c1=O	10.1021/jm060277v
	CHEMBL211521	79240	0	None	2	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	453	8	3	6	2.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCCc4ccccc4)cc3)nc2c1=O	10.1021/jm060277v
	44451303	168577	0	None	50	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	564	5	1	9	3.2	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL440418	168577	0	None	50	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	564	5	1	9	3.2	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	156019075	177297	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2[C@@H]1c1cocn1	10.1021/acs.jmedchem.0c00564
	CHEMBL4644677	177297	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2[C@@H]1c1cocn1	10.1021/acs.jmedchem.0c00564
	57429607	159183	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	441	6	1	8	2.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C#N)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4104876	159183	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	441	6	1	8	2.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C#N)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	10926422	99170	0	None	4	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	358	6	2	7	1.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)OC)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL284288	99170	0	None	4	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	358	6	2	7	1.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)OC)cc3)nc2c1=O	10.1021/jm011049y
	456	346	51	None	15	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	10.1021/jm058018d
	5372720	346	51	None	15	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	10.1021/jm058018d
	CHEMBL68500	346	51	None	15	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	10.1021/jm058018d
	11143648	154301	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	390	5	1	5	3.1	CCCn1c(=O)c2nc(-c3ccc(Br)cc3)[nH]c2n(CCC)c1=O	10.1021/jm011049y
	CHEMBL40055	154301	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	390	5	1	5	3.1	CCCn1c(=O)c2nc(-c3ccc(Br)cc3)[nH]c2n(CCC)c1=O	10.1021/jm011049y
	11640539	140355	0	None	-1	4	Human	8.4	pKi	=	8.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	429	5	2	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL382135	140355	0	None	-1	4	Human	8.4	pKi	=	8.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	429	5	2	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11618962	72281	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	436	5	2	6	2.8	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)Nc1ccc(F)cc1	10.1021/jm0506221
	CHEMBL199486	72281	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	436	5	2	6	2.8	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)Nc1ccc(F)cc1	10.1021/jm0506221
	10917575	80717	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	463	5	1	11	2.9	CSc1c2c(nc(NC(=O)Cc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL21572	80717	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	463	5	1	11	2.9	CSc1c2c(nc(NC(=O)Cc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	21958745	94280	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	432	6	2	6	3.1	CCCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL253049	94280	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	432	6	2	6	3.1	CCCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	10225178	32703	0	None	-5	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 23-40Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 23-40	ChEMBL	438	3	2	6	5.5	O=C(Nc1cccc(Cl)c1)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL141550	32703	0	None	-5	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 23-40Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 23-40	ChEMBL	438	3	2	6	5.5	O=C(Nc1cccc(Cl)c1)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	10225178	32703	0	None	-5	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	438	3	2	6	5.5	O=C(Nc1cccc(Cl)c1)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm0109614
	CHEMBL141550	32703	0	None	-5	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	438	3	2	6	5.5	O=C(Nc1cccc(Cl)c1)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12	10.1021/jm0109614
	11762982	25985	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	513	7	1	8	5.3	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL135719	25985	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	513	7	1	8	5.3	O=C(Cc1cccc2ccccc12)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	46880470	5984	0	None	20	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncc2)c(-c2cnco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1080676	5984	0	None	20	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncc2)c(-c2cnco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	46880506	6293	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	3	1	3	3.9	CC(=O)Nc1ccc(-c2ccncc2)c(-c2cccc(F)c2)n1	10.1016/j.bmcl.2010.01.045
	CHEMBL1082208	6293	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	3	1	3	3.9	CC(=O)Nc1ccc(-c2ccncc2)c(-c2cccc(F)c2)n1	10.1016/j.bmcl.2010.01.045
	136042349	70790	0	None	21	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	480	8	2	9	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(F)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955898	70790	0	None	21	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	480	8	2	9	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(F)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	2690	888	59	None	-30	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	384	888	59	None	-30	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	CHEMBL16687	888	59	None	-30	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	21958724	95741	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	378	6	1	7	2.1	CCCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL260763	95741	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	378	6	1	7	2.1	CCCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O	10.1021/jm7014815
	176407	4069	76	None	-34	6	Human	7.5	pKi	=	7.5	Binding	Selectivity for recombinant human adenosine A2b receptorSelectivity for recombinant human adenosine A2b receptor	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm0498405
	405	4069	76	None	-34	6	Human	7.5	pKi	=	7.5	Binding	Selectivity for recombinant human adenosine A2b receptorSelectivity for recombinant human adenosine A2b receptor	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm0498405
	CHEMBL113142	4069	76	None	-34	6	Human	7.5	pKi	=	7.5	Binding	Selectivity for recombinant human adenosine A2b receptorSelectivity for recombinant human adenosine A2b receptor	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm0498405
	DB08770	4069	76	None	-34	6	Human	7.5	pKi	=	7.5	Binding	Selectivity for recombinant human adenosine A2b receptorSelectivity for recombinant human adenosine A2b receptor	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm0498405
	44450903	95637	0	None	28	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	532	7	1	8	3.0	COc1ccc(C2CCN(C(=O)COc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3OC)CC2)cc1	10.1016/j.bmc.2008.01.002
	CHEMBL260179	95637	0	None	28	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	532	7	1	8	3.0	COc1ccc(C2CCN(C(=O)COc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3OC)CC2)cc1	10.1016/j.bmc.2008.01.002
	46837839	10641	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	464	7	1	7	3.3	CCCn1c(=O)c2c(cc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)n2C)n(C)c1=O	10.1016/j.ejmech.2010.03.011
	CHEMBL1171380	10641	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	464	7	1	7	3.3	CCCn1c(=O)c2c(cc(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)n2C)n(C)c1=O	10.1016/j.ejmech.2010.03.011
	16109435	2337	7	None	-338	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	353	3	1	2	6.3	C1CCC(CC1)c1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1	10.1021/jm0607956
	5607	2337	7	None	-338	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	353	3	1	2	6.3	C1CCC(CC1)c1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1	10.1021/jm0607956
	CHEMBL219160	2337	7	None	-338	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	353	3	1	2	6.3	C1CCC(CC1)c1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1	10.1021/jm0607956
	16109430	82993	1	None	-489	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	339	3	1	2	6.0	c1ccc(-c2cc(-c3ccccc3)c3nc(C4CCCC4)[nH]c3n2)cc1	10.1021/jm0607956
	CHEMBL219625	82993	1	None	-489	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	339	3	1	2	6.0	c1ccc(-c2cc(-c3ccccc3)c3nc(C4CCCC4)[nH]c3n2)cc1	10.1021/jm0607956
	16109428	83850	1	None	-489	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	313	3	1	2	5.4	CC(C)c1nc2c(-c3ccccc3)cc(-c3ccccc3)nc2[nH]1	10.1021/jm0607956
	CHEMBL221343	83850	1	None	-489	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	313	3	1	2	5.4	CC(C)c1nc2c(-c3ccccc3)cc(-c3ccccc3)nc2[nH]1	10.1021/jm0607956
	44418996	83875	1	None	-549	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	327	4	1	2	5.5	CC(C)Cc1nc2c(-c3ccccc3)cc(-c3ccccc3)nc2[nH]1	10.1021/jm0607956
	CHEMBL221486	83875	1	None	-549	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	327	4	1	2	5.5	CC(C)Cc1nc2c(-c3ccccc3)cc(-c3ccccc3)nc2[nH]1	10.1021/jm0607956
	16109429	141064	1	None	-346	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	341	5	1	2	6.2	CCC(CC)c1nc2c(-c3ccccc3)cc(-c3ccccc3)nc2[nH]1	10.1021/jm0607956
	CHEMBL385109	141064	1	None	-346	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	341	5	1	2	6.2	CCC(CC)c1nc2c(-c3ccccc3)cc(-c3ccccc3)nc2[nH]1	10.1021/jm0607956
	11533237	77328	0	None	10	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	488	7	1	7	4.1	CC(C)Cn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(CC(C)C)c1=O	10.1021/jm051268+
	CHEMBL208920	77328	0	None	10	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	488	7	1	7	4.1	CC(C)Cn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(CC(C)C)c1=O	10.1021/jm051268+
	135401232	3145	5	None	-24547	7	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	397	2	1	3	4.4	CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C	10.1016/j.ejmech.2019.111879
	5619	3145	5	None	-24547	7	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	397	2	1	3	4.4	CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C	10.1016/j.ejmech.2019.111879
	CHEMBL1562432	3145	5	None	-24547	7	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	397	2	1	3	4.4	CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C	10.1016/j.ejmech.2019.111879
	2519	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	407	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	463	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	CHEMBL113	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	DB00201	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.7b01627
	10457445	102705	0	None	-93	3	Rat	6.5	pKi	=	6.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	470	14	4	6	5.0	CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
	CHEMBL308295	102705	0	None	-93	3	Rat	6.5	pKi	=	6.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	470	14	4	6	5.0	CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
	10905184	119622	0	None	-30	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 244-373Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 244-373	ChEMBL	388	3	2	8	3.2	Cc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm0109614
	CHEMBL351285	119622	0	None	-30	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 244-373Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 244-373	ChEMBL	388	3	2	8	3.2	Cc1ccc(NC(=O)Nc2nc3nn(C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm0109614
	50940966	56973	0	None	-30	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	269	3	1	5	3.0	CC(=O)Nc1cc(-c2ccoc2)nc(-c2ccoc2)n1	10.1021/jm100843z
	CHEMBL1650390	56973	0	None	-30	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	269	3	1	5	3.0	CC(=O)Nc1cc(-c2ccoc2)nc(-c2ccoc2)n1	10.1021/jm100843z
	71680734	89768	0	None	-13	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	354	6	1	5	3.6	COc1cccc(CCCC(=O)Nc2nc3ccccc3c(=O)s2)c1	10.1021/jm400336x
	CHEMBL2382435	89768	0	None	-13	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	354	6	1	5	3.6	COc1cccc(CCCC(=O)Nc2nc3ccccc3c(=O)s2)c1	10.1021/jm400336x
	135486118	110856	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	511	9	2	9	2.8	CC(C)Cn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CC(C)C)c1=O	10.1021/jm0309654
	CHEMBL32697	110856	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	511	9	2	9	2.8	CC(C)Cn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)nn3C)[nH]c2n(CC(C)C)c1=O	10.1021/jm0309654
	10623248	112130	0	None	-29	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 260-352Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 260-352	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL330286	112130	0	None	-29	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 260-352Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 260-352	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	10623248	112130	0	None	-29	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm010818a
	CHEMBL330286	112130	0	None	-29	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm010818a
	10623248	112130	0	None	-29	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 262-352Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 262-352	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL330286	112130	0	None	-29	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 262-352Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 262-352	ChEMBL	446	7	2	9	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	155522786	170175	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	318	3	2	4	2.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4452495	170175	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	318	3	2	4	2.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	10884803	120257	0	None	-11	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	6	2	10	3.7	CCCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL355415	120257	0	None	-11	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	6	2	10	3.7	CCCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	145991489	166276	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	607	15	2	10	3.4	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCNC3CCCCC3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	CHEMBL4285218	166276	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	607	15	2	10	3.4	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCNC3CCCCC3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	162665544	181671	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	276	3	2	4	2.0	CC1=C(C(=O)OC2CCC2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4783746	181671	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	276	3	2	4	2.0	CC1=C(C(=O)OC2CCC2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	50940926	56923	0	None	-6	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	339	4	1	3	4.4	CCC(=O)Nc1nc(-c2ccccc2F)cc(-c2ccccc2F)n1	10.1021/jm100843z
	CHEMBL1650164	56923	0	None	-6	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	339	4	1	3	4.4	CCC(=O)Nc1nc(-c2ccccc2F)cc(-c2ccccc2F)n1	10.1021/jm100843z
	10884000	75181	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	405	6	1	9	3.7	CSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1CCCc1ccccc1	10.1021/jm021023m
	CHEMBL20445	75181	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	405	6	1	9	3.7	CSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1CCCc1ccccc1	10.1021/jm021023m
	11081189	119856	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 25-40Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 25-40	ChEMBL	470	5	2	8	5.1	CCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL353299	119856	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 25-40Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 25-40	ChEMBL	470	5	2	8	5.1	CCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11080491	22579	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	429	7	1	8	4.0	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	CHEMBL132806	22579	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	429	7	1	8	4.0	CC(C)CCn1cc2c(nc(NC(=O)Cc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm030852k
	21916357	95933	0	None	10	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	410	6	1	7	2.6	CCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc21	10.1021/jm7014815
	CHEMBL261819	95933	0	None	10	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	410	6	1	7	2.6	CCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc21	10.1021/jm7014815
	21958764	96373	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	378	6	1	7	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL265212	96373	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	378	6	1	7	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL5086406	213244	3	None	-14	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		COc1cccc(-c2nc(N)nc(-c3ccccc3)c2C#N)c1	10.1021/acs.jmedchem.1c01636
	156009568	176577	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	336	3	2	5	3.6	CC1=C(C(=O)OC(C)C)C(c2ccc[nH]2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4634269	176577	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	336	3	2	5	3.6	CC1=C(C(=O)OC(C)C)C(c2ccc[nH]2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	11568060	77511	0	None	-17	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	425	6	3	6	2.3	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Nc4ccccc4)cc3)nc2c1=O	10.1021/jm060277v
	CHEMBL209366	77511	0	None	-17	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	425	6	3	6	2.3	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Nc4ccccc4)cc3)nc2c1=O	10.1021/jm060277v
	44451483	160568	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	5	1	7	2.7	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL411720	160568	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	501	5	1	7	2.7	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	49798135	10759	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	521	7	2	7	4.5	CCCn1c(=O)[nH]c2cc(-c3ccc(OCc4nc(-c5ccc(Br)cc5)no4)cc3)[nH]c2c1=O	10.1016/j.ejmech.2010.03.011
	CHEMBL1172502	10759	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	521	7	2	7	4.5	CCCn1c(=O)[nH]c2cc(-c3ccc(OCc4nc(-c5ccc(Br)cc5)no4)cc3)[nH]c2c1=O	10.1016/j.ejmech.2010.03.011
	44308520	103110	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	348	5	1	5	2.7	CCCn1c(=O)c2nc(-c3c(F)cccc3F)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL308660	103110	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	348	5	1	5	2.7	CCCn1c(=O)c2nc(-c3c(F)cccc3F)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	11545341	77655	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	378	6	1	7	2.6	CCCn1c(=O)c2nc(-c3cnn(-c4ccccc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL209831	77655	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	378	6	1	7	2.6	CCCn1c(=O)c2nc(-c3cnn(-c4ccccc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	135428653	81143	0	None	-295	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	441	7	2	4	4.3	CCCN1C(=O)N2C[C@@H](C(C)C)N=C2c2[nH]c(C34CCC(CCC(=O)O)(CC3)CC4)nc21	10.1021/jm060539t
	CHEMBL216200	81143	0	None	-295	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	441	7	2	4	4.3	CCCN1C(=O)N2C[C@@H](C(C)C)N=C2c2[nH]c(C34CCC(CCC(=O)O)(CC3)CC4)nc21	10.1021/jm060539t
	11257336	200175	0	None	-380	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]PSB-298 binding to adenosine A2b receptorInhibition of [3H]PSB-298 binding to adenosine A2b receptor	ChEMBL	374	5	1	6	2.3	CCCn1c(=O)c2nc(C3=CC(C)(C)N([O])C3(C)C)[nH]c2n(CCC)c1=O	10.1021/jm049513x
	CHEMBL607302	200175	0	None	-380	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]PSB-298 binding to adenosine A2b receptorInhibition of [3H]PSB-298 binding to adenosine A2b receptor	ChEMBL	374	5	1	6	2.3	CCCn1c(=O)c2nc(C3=CC(C)(C)N([O])C3(C)C)[nH]c2n(CCC)c1=O	10.1021/jm049513x
	11067937	201917	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	344	5	0	6	2.0	C=CCn1c(=O)c2c(nc(-c3ccccc3)n2CCCl)n(C)c1=O	10.1021/jm0104318
	CHEMBL67110	201917	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	344	5	0	6	2.0	C=CCn1c(=O)c2c(nc(-c3ccccc3)n2CCCl)n(C)c1=O	10.1021/jm0104318
	76309932	103352	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	292	3	1	5	1.7	CCOC(=O)C1=C(C)NC(=O)N(C(C)=O)C1c1ccco1	10.1021/ml400185v
	CHEMBL3091696	103352	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	292	3	1	5	1.7	CCOC(=O)C1=C(C)NC(=O)N(C(C)=O)C1c1ccco1	10.1021/ml400185v
	3286	3148	24	None	-26	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]PSB-603 from recombinant rat A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	5311479	3148	24	None	-26	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]PSB-603 from recombinant rat A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	CHEMBL8565	3148	24	None	-26	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]PSB-603 from recombinant rat A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant rat A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins by liquid scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	47104774	103359	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	296	3	2	4	2.5	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091705	103359	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	296	3	2	4	2.5	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	46227993	198005	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	326	4	1	7	1.2	Cn1c(=O)c2[nH]c(Cc3ccco3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL593216	198005	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	326	4	1	7	1.2	Cn1c(=O)c2[nH]c(Cc3ccco3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	395949	72145	19	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	218	2	2	4	1.0	COc1cccc2cc(C(N)=O)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	CHEMBL1990267	72145	19	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	218	2	2	4	1.0	COc1cccc2cc(C(N)=O)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	3288	1817	32	None	-10232	5	Human	4.5	pKi	=	4.5	Binding	Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsAgonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cells	ChEMBL	351	4	5	10	-1.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1CCC[C@@H]1O	10.1007/s00044-004-0013-y
	9884817	1817	32	None	-10232	5	Human	4.5	pKi	=	4.5	Binding	Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsAgonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cells	ChEMBL	351	4	5	10	-1.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1CCC[C@@H]1O	10.1007/s00044-004-0013-y
	CHEMBL2163568	1817	32	None	-10232	5	Human	4.5	pKi	=	4.5	Binding	Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsAgonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cells	ChEMBL	351	4	5	10	-1.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H]1CCC[C@@H]1O	10.1007/s00044-004-0013-y
	44520976	200496	4	None	-1258	4	Human	5.5	pKi	=	5.5	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	323	4	2	6	2.3	Cc1cccc(CNC(=O)c2cc(-c3ccc(C)o3)nc(N)n2)n1	10.1016/j.bmc.2009.07.078
	CHEMBL609578	200496	4	None	-1258	4	Human	5.5	pKi	=	5.5	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	323	4	2	6	2.3	Cc1cccc(CNC(=O)c2cc(-c3ccc(C)o3)nc(N)n2)n1	10.1016/j.bmc.2009.07.078
	44520976	200496	4	None	-1258	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	323	4	2	6	2.3	Cc1cccc(CNC(=O)c2cc(-c3ccc(C)o3)nc(N)n2)n1	10.1021/jm4011669
	CHEMBL609578	200496	4	None	-1258	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	323	4	2	6	2.3	Cc1cccc(CNC(=O)c2cc(-c3ccc(C)o3)nc(N)n2)n1	10.1021/jm4011669
	135529386	486	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	440	486	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	CHEMBL284615	486	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	135529386	486	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	440	486	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	CHEMBL284615	486	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	10.1021/jm0309654
	46880422	5955	0	None	22	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncc2)c(-c2ncco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1080500	5955	0	None	22	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncc2)c(-c2ncco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	16070448	57699	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	317	4	1	5	2.9	O=C(Nc1cnc(-c2ccncc2)c(-c2ccncc2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672622	57699	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	317	4	1	5	2.9	O=C(Nc1cnc(-c2ccncc2)c(-c2ccncc2)n1)C1CC1	10.1021/ml100249e
	44406643	132626	0	None	15	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5cccc(Cl)c5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL370380	132626	0	None	15	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5cccc(Cl)c5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	44451482	166322	0	None	16	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	503	6	1	8	2.0	COc1cc(OCC(=O)N2CCN(c3ccccc3)CC2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	CHEMBL428605	166322	0	None	16	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	503	6	1	8	2.0	COc1cc(OCC(=O)N2CCN(c3ccccc3)CC2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	46227984	199599	0	None	4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	340	4	0	8	1.3	Cn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL604075	199599	0	None	4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	340	4	0	8	1.3	Cn1c(=O)c2c(nc(Cc3ccco3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	9843101	197414	0	None	-7943	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	385	6	1	7	3.9	COc1cc(-c2nc(NC(C)=O)sc2-c2ccncc2)cc(OC)c1OC	10.1016/j.ejmech.2019.111879
	CHEMBL589080	197414	0	None	-7943	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	385	6	1	7	3.9	COc1cc(-c2nc(NC(C)=O)sc2-c2ccncc2)cc(OC)c1OC	10.1016/j.ejmech.2019.111879
	45268927	194461	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	342	7	1	6	2.0	CCCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL561167	194461	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	342	7	1	6	2.0	CCCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	2732424	21977	27	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	282	3	2	5	2.5	CCOC(=O)C1=C(C)N=C(S)NC1c1cccs1	10.1021/acs.jmedchem.0c01431
	CHEMBL1322729	21977	27	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	282	3	2	5	2.5	CCOC(=O)C1=C(C)N=C(S)NC1c1cccs1	10.1021/acs.jmedchem.0c01431
	44390559	65233	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccccc5C(F)(F)F)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL183183	65233	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccccc5C(F)(F)F)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	50940932	56932	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	315	4	1	5	4.3	CCC(=O)Nc1nc(-c2ccsc2)cc(-c2ccsc2)n1	10.1021/jm100843z
	CHEMBL1650347	56932	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	315	4	1	5	4.3	CCC(=O)Nc1nc(-c2ccsc2)cc(-c2ccsc2)n1	10.1021/jm100843z
	162675258	182763	0	None	9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	4	2.1	CC1=C(C(=O)OCC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4797674	182763	0	None	9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	4	2.1	CC1=C(C(=O)OCC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	46880509	6064	0	None	44	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	4	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2cccnc2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081040	6064	0	None	44	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	4	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2cccnc2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	11495161	77873	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	406	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4C)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210747	77873	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	406	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4C)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	541615	97063	1	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	385	8	2	7	1.2	CCCn1c(=O)c2nc(-c3ccc(OCC(N)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL27043	97063	1	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	385	8	2	7	1.2	CCCn1c(=O)c2nc(-c3ccc(OCC(N)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	45271363	193751	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	478	10	2	9	2.0	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4cccnc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL552304	193751	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	478	10	2	9	2.0	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4cccnc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11569877	132911	0	None	6	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	518	11	3	7	3.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC(=O)O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL370629	132911	0	None	6	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	518	11	3	7	3.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC(=O)O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	137639632	156367	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	439	7	1	9	0.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCOCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4072350	156367	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	439	7	1	9	0.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCOCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL5089580	213430	0	None	-1174	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL		None	None	None		Nc1nc(-c2ccc(OCCCN3CCCCC3)cc2)c2c(n1)-c1ccccc1C2=O	10.1021/acs.jmedchem.0c00914
	164617060	184817	0	None	-363	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK cell membrane incubated for 30 mins by microplate beta scintillation counting based radioligand inhibition assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK cell membrane incubated for 30 mins by microplate beta scintillation counting based radioligand inhibition assay	ChEMBL	440	9	4	9	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.ejmech.2021.113607
	CHEMBL4861092	184817	0	None	-363	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK cell membrane incubated for 30 mins by microplate beta scintillation counting based radioligand inhibition assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK cell membrane incubated for 30 mins by microplate beta scintillation counting based radioligand inhibition assay	ChEMBL	440	9	4	9	1.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1016/j.ejmech.2021.113607
	22266740	95825	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	480	7	1	10	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL261182	95825	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	480	7	1	10	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	10861697	102551	0	None	-4	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	374	7	0	6	3.1	CCCn1c(=O)c2c(nc(-c3ccccc3)n2CCCl)n(CCC)c1=O	10.1021/jm0104318
	CHEMBL307105	102551	0	None	-4	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	374	7	0	6	3.1	CCCn1c(=O)c2c(nc(-c3ccccc3)n2CCCl)n(CCC)c1=O	10.1021/jm0104318
	1241166	197594	20	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	356	5	1	4	5.8	O=C(c1ccccc1)c1sc(Nc2ccccc2)nc1-c1ccccc1	10.1016/j.bmc.2010.01.072
	CHEMBL590302	197594	20	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	356	5	1	4	5.8	O=C(c1ccccc1)c1sc(Nc2ccccc2)nc1-c1ccccc1	10.1016/j.bmc.2010.01.072
	127043829	140674	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	552	13	0	10	3.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN3CCOCC3)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	CHEMBL3828555	140674	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	552	13	0	10	3.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN3CCOCC3)cc2)n(CCCC)c1=O	10.1016/j.bmc.2016.07.028
	44587954	173851	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	371	6	3	6	2.4	CCCn1c(=O)c2[nH]c(-c3ccc(C(=O)O)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL455315	173851	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	371	6	3	6	2.4	CCCn1c(=O)c2[nH]c(-c3ccc(C(=O)O)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	127043664	140663	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	510	13	0	9	3.4	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN(CC)CC)cc2)n(CCC)c1=O	10.1016/j.bmc.2016.07.028
	CHEMBL3828401	140663	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	510	13	0	9	3.4	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN(CC)CC)cc2)n(CCC)c1=O	10.1016/j.bmc.2016.07.028
	52950000	18919	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	505	8	2	4	5.2	N#Cc1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	CHEMBL1289344	18919	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	505	8	2	4	5.2	N#Cc1c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)ccc2[nH]c1=O	10.1016/j.bmcl.2010.10.030
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1039/C8MD00070K
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1039/C8MD00070K
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1039/C8MD00070K
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1039/C8MD00070K
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1039/C8MD00070K
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.5b01586
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.5b01586
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.5b01586
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.5b01586
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/acs.jmedchem.5b01586
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membraneDisplacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membrane	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2016.09.003
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membraneDisplacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membrane	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2016.09.003
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membraneDisplacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membrane	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2016.09.003
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membraneDisplacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membrane	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2016.09.003
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membraneDisplacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membrane	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2016.09.003
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2013.09.044
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2010.01.072
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2010.01.072
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2010.01.072
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2010.01.072
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2010.01.072
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2019.111879
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2019.111879
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2019.111879
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2019.111879
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2019.111879
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm900413e
	2519	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cellsDisplacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2019.02.004
	407	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cellsDisplacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2019.02.004
	463	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cellsDisplacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2019.02.004
	CHEMBL113	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cellsDisplacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2019.02.004
	DB00201	765	83	None	-9	12	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cellsDisplacement of [3H]PSB603 from recombinant human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2019.02.004
	44459941	96237	3	None	1	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	246	4	0	6	0.3	C=CCn1c(=O)c2c(ncn2C)n(CC=C)c1=O	10.1021/jm0104318
	CHEMBL26406	96237	3	None	1	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	246	4	0	6	0.3	C=CCn1c(=O)c2c(ncn2C)n(CC=C)c1=O	10.1021/jm0104318
	10563436	134694	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	262	3	2	4	1.5	CCCn1c(=O)[nH]c2[nH]c(C3CCCC3)nc2c1=O	10.1021/jm0104318
	CHEMBL37243	134694	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	262	3	2	4	1.5	CCCn1c(=O)[nH]c2[nH]c(C3CCCC3)nc2c1=O	10.1021/jm0104318
	136002186	109200	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32281	109200	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	136002186	109200	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32281	109200	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	21958725	94113	0	None	3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	364	6	2	6	2.1	CCCCn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251874	94113	0	None	3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	364	6	2	6	2.1	CCCCn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	11667107	143848	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	332	4	1	7	2.6	[O-][n+]1cccc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)c1	10.1021/jm061333v
	CHEMBL390600	143848	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	332	4	1	7	2.6	[O-][n+]1cccc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)c1	10.1021/jm061333v
	11812897	119780	0	None	3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 26-45Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 26-45	ChEMBL	484	6	2	8	5.5	CCCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL352707	119780	0	None	3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 26-45Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 26-45	ChEMBL	484	6	2	8	5.5	CCCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	2817165	188224	5	None	-91	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	251	2	1	5	3.1	N#Cc1c(-c2ccco2)cc(-c2ccco2)nc1N	10.1021/jm701594y
	CHEMBL506250	188224	5	None	-91	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	251	2	1	5	3.1	N#Cc1c(-c2ccco2)cc(-c2ccco2)nc1N	10.1021/jm701594y
	11524637	77718	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	422	8	1	8	2.6	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(OC)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210150	77718	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	422	8	1	8	2.6	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(OC)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	2690	888	59	None	-30	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	384	888	59	None	-30	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	CHEMBL16687	888	59	None	-30	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	10563436	134694	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	262	3	2	4	1.5	CCCn1c(=O)[nH]c2[nH]c(C3CCCC3)nc2c1=O	10.1021/jm011049y
	CHEMBL37243	134694	0	None	-3	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	262	3	2	4	1.5	CCCn1c(=O)[nH]c2[nH]c(C3CCCC3)nc2c1=O	10.1021/jm011049y
	CHEMBL5088749	213392	0	None	-11	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		CNc1nc(-c2ccccc2)c(C#N)c(-c2cccc(C#N)c2)n1	10.1021/acs.jmedchem.1c01636
	11656950	71925	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	557	10	2	8	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C5=NC(C)(C)CO5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL198294	71925	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	557	10	2	8	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C5=NC(C)(C)CO5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11569133	72252	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	476	9	3	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199399	72252	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	476	9	3	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	156019760	177364	0	None	-40	2	Human	6.5	pKi	=	6.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	2	6	3.0	CC1=C(C(=O)OC(C)C)C(c2cn[nH]c2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4645687	177364	0	None	-40	2	Human	6.5	pKi	=	6.5	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	3	2	6	3.0	CC1=C(C(=O)OC(C)C)C(c2cn[nH]c2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	145986838	166519	0	None	-2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	581	16	1	10	2.9	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCN(CC)CC)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	CHEMBL4289660	166519	0	None	-2	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	581	16	1	10	2.9	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCN(CC)CC)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	135465784	162300	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	495	9	3	10	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(O)c(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL417312	162300	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	495	9	3	10	2.0	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(O)c(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	72546540	103351	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	248	3	1	5	1.5	CCOC(=O)c1c(-c2ccco2)nc(=O)[nH]c1C	10.1021/ml400185v
	CHEMBL3091695	103351	1	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	248	3	1	5	1.5	CCOC(=O)c1c(-c2ccco2)nc(=O)[nH]c1C	10.1021/ml400185v
	137652737	158031	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	304	3	2	5	2.0	CC1=C(C(=O)OC(C)C)C(c2cccs2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL4092030	158031	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	304	3	2	5	2.0	CC1=C(C(=O)OC(C)C)C(c2cccs2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL5076343	212648	2	None	-158	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis	ChEMBL		None	None	None		Nc1ccccc1NC(=O)c1ccc(CCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1	10.1021/acs.jmedchem.1c01155
	135493268	109984	0	None	25	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32481	109984	0	None	25	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135493268	109984	0	None	25	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32481	109984	0	None	25	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	449	8	2	8	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccccc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10926253	80631	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	353	2	1	10	0.6	CN1CCN(c2c3c(nc(N)n4nc(-c5ccco5)nc34)nn2C)CC1	10.1021/jm021023m
	CHEMBL21541	80631	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	353	2	1	10	0.6	CN1CCN(c2c3c(nc(N)n4nc(-c5ccco5)nc34)nn2C)CC1	10.1021/jm021023m
	CHEMBL553587	80631	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	353	2	1	10	0.6	CN1CCN(c2c3c(nc(N)n4nc(-c5ccco5)nc34)nn2C)CC1	10.1021/jm021023m
	11733496	24686	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	477	8	1	8	4.5	O=C(Cc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL134566	24686	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	477	8	1	8	4.5	O=C(Cc1ccccc1)Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	10994216	193240	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	463	7	1	8	4.2	O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL541455	193240	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	463	7	1	8	4.2	O=C(Cc1ccccc1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	44587955	188350	0	None	11	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	397	7	2	8	1.8	CCCn1c(=O)c2[nH]c(-c3ccco3)c(OS(=O)(=O)O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL508090	188350	0	None	11	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	397	7	2	8	1.8	CCCn1c(=O)c2[nH]c(-c3ccco3)c(OS(=O)(=O)O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	136042342	70809	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	479	9	2	10	2.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(OC)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955918	70809	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	479	9	2	10	2.8	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(OC)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	135874415	95437	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	527	8	2	8	3.3	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Br)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL259177	95437	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	527	8	2	8	3.3	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Br)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	11956193	94128	8	None	-12	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	367	5	1	8	1.1	CN1CCN(CC(=O)Nc2cc(-n3cccn3)nc(-c3ccco3)n2)CC1	10.1021/jm070623o
	CHEMBL251975	94128	8	None	-12	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptorDisplacement of [3H]MRS1754 from human adenosine A2B receptor	ChEMBL	367	5	1	8	1.1	CN1CCN(CC(=O)Nc2cc(-n3cccn3)nc(-c3ccco3)n2)CC1	10.1021/jm070623o
	24828457	96374	0	None	27	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	6	1	7	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL265213	96374	0	None	27	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	6	1	7	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	11647607	77725	0	None	4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	428	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(F)c(F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210212	77725	0	None	4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	428	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(F)c(F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	1153	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	12668023	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	30026874	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	30026875	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	3341	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	6603851	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	933	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	939	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	985	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	CHEMBL1160786	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	CHEMBL1161520	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	CHEMBL588	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	DB00800	1591	53	None	-5	10	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
	46227951	198253	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	6	0	8	2.6	Cn1c(Cc2cccs2)nc2c1c(=O)n(CC1CC1)c(=O)n2Cc1ccco1	10.1016/j.bmc.2009.07.034
	CHEMBL594963	198253	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	6	0	8	2.6	Cn1c(Cc2cccs2)nc2c1c(=O)n(CC1CC1)c(=O)n2Cc1ccco1	10.1016/j.bmc.2009.07.034
	46233377	199563	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	386	5	0	8	2.7	CCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2cccs2)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL603878	199563	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	386	5	0	8	2.7	CCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2cccs2)c1=O	10.1016/j.bmc.2010.01.028
	135423046	37456	0	None	-77	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 332-369Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 332-369	ChEMBL	390	4	3	8	2.9	COc1ccc(NC(=O)Nc2nc3n[nH]cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	CHEMBL145767	37456	0	None	-77	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 332-369Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 332-369	ChEMBL	390	4	3	8	2.9	COc1ccc(NC(=O)Nc2nc3n[nH]cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	11642231	77125	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	528	7	1	7	4.7	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL208723	77125	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	528	7	1	7	4.7	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	135633268	138432	8	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	288	3	1	7	2.1	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2ncnc2N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785325	138432	8	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	288	3	1	7	2.1	CC1=C(C(=O)OC(C)C)C(c2ccoc2)n2ncnc2N1	10.1021/acs.jmedchem.5b01586
	5613	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	10.1021/jm4011669
	9860294	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	10.1021/jm4011669
	CHEMBL197669	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	10.1021/jm4011669
	5613	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	10.1021/jm058018d
	9860294	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	10.1021/jm058018d
	CHEMBL197669	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	10.1021/jm058018d
	72697652	103526	0	None	-26	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	349	3	0	7	0.9	C#CCn1c(=O)c2c(nc3n2CCCN3Cc2ccccc2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL3093310	103526	0	None	-26	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	349	3	0	7	0.9	C#CCn1c(=O)c2c(nc3n2CCCN3Cc2ccccc2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	10254700	201823	6	None	-478	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	483	5	4	9	0.7	OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9905965
	CHEMBL66393	201823	6	None	-478	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	483	5	4	9	0.7	OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm9905965
	CHEMBL5078609	212787	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		CNc1nc(-c2ccccc2)c(C#N)c(-c2cccc(F)c2)n1	10.1021/acs.jmedchem.1c01636
	135443359	487	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	441	487	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL431703	487	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	135443359	487	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	441	487	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL431703	487	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	10859484	77290	0	None	-5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	298	3	2	9	1.3	CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL20888	77290	0	None	-5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	298	3	2	9	1.3	CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL544678	77290	0	None	-5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	298	3	2	9	1.3	CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	11560510	138472	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	406	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(C)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL378570	138472	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	406	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(C)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	44307827	201817	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	369	6	2	6	2.3	CCCn1c(=O)c2nc(-c3ccc(NC(C)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL66337	201817	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	369	6	2	6	2.3	CCCn1c(=O)c2nc(-c3ccc(NC(C)=O)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL5088622	213381	0	None	-5	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL		None	None	None		Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCCN3CCCC3)ccc1C2	10.1021/acs.jmedchem.0c00914
	128525	154174	10	None	5	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	CHEMBL39986	154174	10	None	5	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	11713241	77840	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	512	7	1	7	4.4	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)cc(Cl)c4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210614	77840	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	512	7	1	7	4.4	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(C(F)(F)F)cc(Cl)c4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	71681203	89763	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	330	5	1	5	3.7	O=C(CCCc1ccccc1)Nc1nc2sccc2c(=O)s1	10.1021/jm400336x
	CHEMBL2382425	89763	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	330	5	1	5	3.7	O=C(CCCc1ccccc1)Nc1nc2sccc2c(=O)s1	10.1021/jm400336x
	71683091	89493	0	None	-4	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	310	4	1	4	3.2	O=C(CCc1ccccc1)Nc1nc2ccccc2c(=O)s1	10.1021/jm400336x
	CHEMBL2380385	89493	0	None	-4	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	310	4	1	4	3.2	O=C(CCc1ccccc1)Nc1nc2ccccc2c(=O)s1	10.1021/jm400336x
	52945064	18885	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	538	9	1	4	6.0	Cn1c(=O)c(-c2ccc(F)cc2F)c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccccc3)ccc21	10.1016/j.bmcl.2010.10.030
	CHEMBL1289108	18885	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	538	9	1	4	6.0	Cn1c(=O)c(-c2ccc(F)cc2F)c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccccc3)ccc21	10.1016/j.bmcl.2010.10.030
	21958639	63957	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(Cl)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL181062	63957	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(Cl)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	11386951	66536	0	None	-75	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	527	9	5	16	-0.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc([N+](=O)[O-])cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL186403	66536	0	None	-75	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	527	9	5	16	-0.7	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc([N+](=O)[O-])cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	46880418	6247	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	281	4	1	4	2.7	CC(=O)c1nc(NC(=O)C2CC2)ccc1-c1ccncc1	10.1016/j.bmcl.2010.01.045
	CHEMBL1082004	6247	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	281	4	1	4	2.7	CC(=O)c1nc(NC(=O)C2CC2)ccc1-c1ccncc1	10.1016/j.bmcl.2010.01.045
	10379032	7425	0	None	4	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	282	3	1	5	1.3	C=CCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(C)c1=O	10.1021/jm0104318
	CHEMBL10873	7425	0	None	4	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	282	3	1	5	1.3	C=CCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(C)c1=O	10.1021/jm0104318
	10961304	75644	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	6	3	10	3.4	CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL20555	75644	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	6	3	10	3.4	CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL554955	75644	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	447	6	3	10	3.4	CCNc1c2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	21958681	94112	0	None	40	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	336	4	2	6	1.3	CCn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251873	94112	0	None	40	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	336	4	2	6	1.3	CCn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	52944930	19083	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	495	9	2	5	5.1	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290436	19083	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	495	9	2	5	5.1	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)NCc1ccccc1	10.1016/j.bmcl.2010.10.030
	11612320	76913	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4C(F)(F)F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL208110	76913	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	460	7	1	7	3.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4C(F)(F)F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11633189	77854	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	422	8	1	8	2.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(OC)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210683	77854	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	422	8	1	8	2.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(OC)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11582578	139596	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	422	8	1	8	2.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4OC)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL380219	139596	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	422	8	1	8	2.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4OC)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11656185	72236	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	494	9	2	6	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199327	72236	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	494	9	2	6	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	155531922	171154	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	377	3	1	6	4.0	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccoc1	10.1016/j.ejmech.2021.113907
	CHEMBL4467152	171154	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	377	3	1	6	4.0	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccoc1	10.1016/j.ejmech.2021.113907
	155531922	171154	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.9b01340
	CHEMBL4467152	171154	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.9b01340
	135949027	178024	0	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	277	2	2	5	3.2	N#Cc1c(-c2ccc(O)cc2)cc(-c2ccco2)nc1N	10.1021/jm701594y
	CHEMBL467366	178024	0	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	277	2	2	5	3.2	N#Cc1c(-c2ccc(O)cc2)cc(-c2ccco2)nc1N	10.1021/jm701594y
	135433658	3146	3	None	-371	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	295	2	1	3	2.5	CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1	10.1016/j.ejmech.2019.111879
	5620	3146	3	None	-371	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	295	2	1	3	2.5	CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1	10.1016/j.ejmech.2019.111879
	9882625	3146	3	None	-371	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	295	2	1	3	2.5	CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1	10.1016/j.ejmech.2019.111879
	CHEMBL1625681	3146	3	None	-371	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	295	2	1	3	2.5	CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1	10.1016/j.ejmech.2019.111879
	135414399	77777	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	330	5	1	7	1.4	CCCn1c(=O)c2nc(-c3cc(C)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210389	77777	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	330	5	1	7	1.4	CCCn1c(=O)c2nc(-c3cc(C)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	17198003	138436	2	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2cccs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL3785353	138436	2	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2cccs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	17198003	138436	2	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2cccs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785353	138436	2	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2cccs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.5b01586
	17198003	138436	2	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2cccs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL3785353	138436	2	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	353	3	1	6	4.3	CC1=C(C(=O)OC(C)C)C(c2cccs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	11553439	72325	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	415	9	1	8	1.7	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3CCCOC)cc1	10.1021/jm0506221
	CHEMBL199664	72325	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	415	9	1	8	1.7	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3CCCOC)cc1	10.1021/jm0506221
	46233347	198603	0	None	1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	380	5	0	7	2.6	CCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccccc2)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL597354	198603	0	None	1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	380	5	0	7	2.6	CCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccccc2)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL5088305	213367	0	None	1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membranes measured after 3 hrs by radioligand binding assayDisplacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membranes measured after 3 hrs by radioligand binding assay	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)cc(SCc2ncc[nH]2)nc1N	10.1021/acs.jmedchem.0c01856
	10980845	137336	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	344	6	3	6	1.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL37621	137336	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	344	6	3	6	1.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	50940921	56922	0	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	395	6	1	5	5.6	CCC(=O)Nc1nc(-c2ccc(SC)cc2)cc(-c2ccc(SC)cc2)n1	10.1021/jm100843z
	CHEMBL1650152	56922	0	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	395	6	1	5	5.6	CCC(=O)Nc1nc(-c2ccc(SC)cc2)cc(-c2ccc(SC)cc2)n1	10.1021/jm100843z
	10475082	74	15	None	-1995	6	Human	4.4	pKi	=	4.4	Binding	Binding affinity for human adenosine A2b receptor subtype expressed in CHO cellsBinding affinity for human adenosine A2b receptor subtype expressed in CHO cells	ChEMBL	383	4	4	9	0.8	OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/jm049408n
	5591	74	15	None	-1995	6	Human	4.4	pKi	=	4.4	Binding	Binding affinity for human adenosine A2b receptor subtype expressed in CHO cellsBinding affinity for human adenosine A2b receptor subtype expressed in CHO cells	ChEMBL	383	4	4	9	0.8	OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/jm049408n
	CHEMBL251997	74	15	None	-1995	6	Human	4.4	pKi	=	4.4	Binding	Binding affinity for human adenosine A2b receptor subtype expressed in CHO cellsBinding affinity for human adenosine A2b receptor subtype expressed in CHO cells	ChEMBL	383	4	4	9	0.8	OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10.1021/jm049408n
	135546657	157144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL408186	157144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1021/jm0309654
	135546657	157144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL408186	157144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1021/jm0309654
	135546657	157144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL408186	157144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	44406607	72343	0	None	8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccccc5Cl)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL199732	72343	0	None	8	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccccc5Cl)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	21958536	166992	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	300	4	2	6	0.7	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cn[nH]c3)nc21	10.1021/jm7014815
	CHEMBL430050	166992	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	300	4	2	6	0.7	CCn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cn[nH]c3)nc21	10.1021/jm7014815
	135546657	157144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL408186	157144	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	509	10	2	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(NC(=O)Cc4ccc(OC)c(OC)c4)nn3C)nc2n(CCC)c1=O	10.1021/jm051268+
	11555329	72877	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	6	2	7	3.0	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)Nc1ccc(Br)cc1	10.1021/jm0506221
	CHEMBL201243	72877	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	6	2	7	3.0	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)Nc1ccc(Br)cc1	10.1021/jm0506221
	44451200	95671	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	587	10	1	8	3.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(=O)OCc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260433	95671	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	587	10	1	8	3.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(=O)OCc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	46227974	199557	0	None	5	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	430	7	0	8	2.1	COCCn1c(=O)c2c(nc(Cc3c(F)cccc3F)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL603861	199557	0	None	5	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	430	7	0	8	2.1	COCCn1c(=O)c2c(nc(Cc3c(F)cccc3F)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	46880331	6136	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	281	3	1	6	2.2	CC(=O)Nc1ncc(-c2ccncn2)c(-c2ccco2)n1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081458	6136	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	281	3	1	6	2.2	CC(=O)Nc1ncc(-c2ccncn2)c(-c2ccco2)n1	10.1016/j.bmcl.2010.01.045
	46880417	6246	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	273	3	1	3	3.1	O=C(Nc1ccc(-c2ccncc2)c(Cl)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1082003	6246	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	273	3	1	3	3.1	O=C(Nc1ccc(-c2ccncc2)c(Cl)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	2817023	180764	6	None	-31	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	267	2	1	5	3.5	N#Cc1c(-c2ccco2)cc(-c2cccs2)nc1N	10.1021/jm701594y
	CHEMBL476310	180764	6	None	-31	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	267	2	1	5	3.5	N#Cc1c(-c2ccco2)cc(-c2cccs2)nc1N	10.1021/jm701594y
	9880921	189579	0	None	-57	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	337	4	1	9	2.0	Nc1nc(-c2ccco2)c2nnn(Cc3ccccc3[N+](=O)[O-])c2n1	10.1021/jm800961g
	CHEMBL517418	189579	0	None	-57	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	337	4	1	9	2.0	Nc1nc(-c2ccco2)c2nnn(Cc3ccccc3[N+](=O)[O-])c2n1	10.1021/jm800961g
	CHEMBL5083146	213064	0	None	-69	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2cccc(Cl)c2)nc(N)nc1-c1ccc2c(c1)OCO2	10.1021/acs.jmedchem.1c01636
	72697649	103547	0	None	-13	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	413	2	0	7	1.8	C#CCn1c(=O)c2c(nc3n2CCCN3c2cccc(Br)c2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL3093331	103547	0	None	-13	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	413	2	0	7	1.8	C#CCn1c(=O)c2c(nc3n2CCCN3c2cccc(Br)c2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	44410409	75604	0	None	-1949	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	496	7	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4ccccc4OC)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL205327	75604	0	None	-1949	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	496	7	5	11	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4ccccc4OC)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	156010696	176573	0	None	-128	2	Human	6.4	pKi	=	6.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	340	3	1	7	3.3	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1nccs1	10.1021/acs.jmedchem.0c00564
	CHEMBL4634105	176573	0	None	-128	2	Human	6.4	pKi	=	6.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	340	3	1	7	3.3	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1nccs1	10.1021/acs.jmedchem.0c00564
	135443353	110092	0	None	11	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	484	7	3	8	3.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Nc4cccc(Cl)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32552	110092	0	None	11	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	484	7	3	8	3.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Nc4cccc(Cl)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10779327	118891	0	None	-15	6	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 35-45Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 35-45	ChEMBL	283	3	1	8	1.7	CCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL344706	118891	0	None	-15	6	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 35-45Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 35-45	ChEMBL	283	3	1	8	1.7	CCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	16720105	84943	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	347	5	1	9	2.7	COc1ncc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)cn1	10.1021/jm061333v
	CHEMBL226236	84943	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	347	5	1	9	2.7	COc1ncc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)cn1	10.1021/jm061333v
	11698898	139819	0	None	74	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL380821	139819	0	None	74	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	494	8	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	655439	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.5b01586
	CHEMBL1544856	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.5b01586
	655439	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.7b00138
	CHEMBL1544856	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.7b00138
	655439	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	CHEMBL1544856	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	655439	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/ml400185v
	CHEMBL1544856	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/ml400185v
	655439	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.9b01340
	CHEMBL1544856	47117	16	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.9b01340
	126079	4025	20	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm0506221
	451	4025	20	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm0506221
	CHEMBL27041	4025	20	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm0506221
	11174953	16568	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membranes measured after 3 hrs by radioligand binding assayDisplacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membranes measured after 3 hrs by radioligand binding assay	ChEMBL	332	4	2	6	3.1	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccccc1	10.1021/acs.jmedchem.0c01856
	CHEMBL124345	16568	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membranes measured after 3 hrs by radioligand binding assayDisplacement of [3H]PSB-603 from human A2B receptor expressed in CHO cell membranes measured after 3 hrs by radioligand binding assay	ChEMBL	332	4	2	6	3.1	N#Cc1c(N)nc(SCc2ncc[nH]2)c(C#N)c1-c1ccccc1	10.1021/acs.jmedchem.0c01856
	53354632	73922	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	316	2	1	4	4.1	Nc1nnc(-c2cc(Cl)cc(Cl)c2)c(-c2ccccc2)n1	10.1021/jm201376w
	CHEMBL2024112	73922	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	316	2	1	4	4.1	Nc1nnc(-c2cc(Cl)cc(Cl)c2)c(-c2ccccc2)n1	10.1021/jm201376w
	11560981	77893	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	428	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4c(F)cccc4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210890	77893	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	428	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4c(F)cccc4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	7315331	199434	1	None	-5	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	352	5	1	5	4.6	CCOC(=O)Nc1nc(-c2ccccc2)c(C(=O)c2ccccc2)s1	10.1016/j.bmc.2010.01.072
	CHEMBL603129	199434	1	None	-5	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	352	5	1	5	4.6	CCOC(=O)Nc1nc(-c2ccccc2)c(C(=O)c2ccccc2)s1	10.1016/j.bmc.2010.01.072
	10085373	10314	6	None	-616	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	286	2	1	6	0.6	COc1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1021/jm0104318
	CHEMBL11635	10314	6	None	-616	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	286	2	1	6	0.6	COc1ccc(-c2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)cc1	10.1021/jm0104318
	21874613	175595	0	None	-263	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	349	4	2	8	2.8	CC(C)c1cc(Cn2nnc3c(-c4ccco4)nc(N)nc32)ccc1N	10.1021/jm800961g
	CHEMBL459322	175595	0	None	-263	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	349	4	2	8	2.8	CC(C)c1cc(Cn2nnc3c(-c4ccco4)nc(N)nc32)ccc1N	10.1021/jm800961g
	72697931	103329	0	None	-17	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	313	2	0	7	0.3	C#CCn1c(=O)c2c(nc3n2CCCN3C2CCC2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL3091482	103329	0	None	-17	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	313	2	0	7	0.3	C#CCn1c(=O)c2c(nc3n2CCCN3C2CCC2)n(C)c1=O	10.1016/j.bmc.2013.09.044
	10190	920	40	None	-1174	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting methodDisplacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting method	ChEMBL	407	6	1	10	2.1	Nc1nc(c2ccc(o2)C)c2c(n1)n(nn2)Cc1cccc(n1)CO[C@@H]1COCC1	10.1021/acs.jmedchem.0c00237
	44537963	920	40	None	-1174	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting methodDisplacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting method	ChEMBL	407	6	1	10	2.1	Nc1nc(c2ccc(o2)C)c2c(n1)n(nn2)Cc1cccc(n1)CO[C@@H]1COCC1	10.1021/acs.jmedchem.0c00237
	CHEMBL4297184	920	40	None	-1174	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting methodDisplacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting method	ChEMBL	407	6	1	10	2.1	Nc1nc(c2ccc(o2)C)c2c(n1)n(nn2)Cc1cccc(n1)CO[C@@H]1COCC1	10.1021/acs.jmedchem.0c00237
	DB16125	920	40	None	-1174	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting methodDisplacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting method	ChEMBL	407	6	1	10	2.1	Nc1nc(c2ccc(o2)C)c2c(n1)n(nn2)Cc1cccc(n1)CO[C@@H]1COCC1	10.1021/acs.jmedchem.0c00237
	3281	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	10.1016/j.bmc.2010.01.072
	9953065	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	10.1016/j.bmc.2010.01.072
	CHEMBL4204703	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	10.1016/j.bmc.2010.01.072
	CHEMBL592435	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	10.1016/j.bmc.2010.01.072
	DB12446	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	10.1016/j.bmc.2010.01.072
	57429645	156454	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	557	8	1	8	4.2	CCCn1c(=O)c2[nH]c(-c3cnn(C(C)C4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4073346	156454	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	557	8	1	8	4.2	CCCn1c(=O)c2[nH]c(-c3cnn(C(C)C4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	69031481	156523	0	None	81	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	529	7	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4074253	156523	0	None	81	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	529	7	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	69029798	157653	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	520	9	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(F)cc5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4088043	157653	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	520	9	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(F)cc5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	66893509	157942	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	559	9	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(OC(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4091110	157942	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	559	9	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(OC(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	46880507	6062	0	None	8	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	333	4	1	3	4.3	O=C(Nc1ccc(-c2ccncc2)c(-c2ccc(F)cc2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081038	6062	0	None	8	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	333	4	1	3	4.3	O=C(Nc1ccc(-c2ccncc2)c(-c2ccc(F)cc2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	46866592	6239	0	None	60	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncn2)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	46866592	6239	0	None	60	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncn2)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.077
	CHEMBL1081971	6239	0	None	60	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncn2)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081971	6239	0	None	60	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	306	4	1	5	3.1	O=C(Nc1ccc(-c2ccncn2)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.077
	56924646	70813	0	None	186	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	332	5	2	7	0.4	CCCn1c(=O)c2[nH]c(-c3cc(=O)[nH]n3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955922	70813	0	None	186	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	332	5	2	7	0.4	CCCn1c(=O)c2[nH]c(-c3cc(=O)[nH]n3C)nc2n(CCC)c1=O	10.1021/jm201292w
	49797905	10628	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	517	7	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(C(F)(F)F)c4)c3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1171164	10628	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	517	7	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(C(F)(F)F)c4)c3)sc12	10.1016/j.bmcl.2011.02.053
	49797748	10505	0	None	25	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	480	6	1	6	4.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCCCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170135	10505	0	None	25	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	480	6	1	6	4.6	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCCCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	49797905	10628	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	517	7	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(C(F)(F)F)c4)c3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171164	10628	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	517	7	1	7	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(C(F)(F)F)c4)c3)sc12	10.1016/j.bmcl.2010.05.056
	49797773	10741	0	None	17	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	490	8	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(CN(C)S(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172277	10741	0	None	17	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	490	8	1	7	3.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(CN(C)S(C)(=O)=O)cc3)sc12	10.1016/j.bmcl.2010.05.056
	11555462	72675	0	None	11	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	522	10	2	6	4.7	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)NCc4ccc(Cl)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201028	72675	0	None	11	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	522	10	2	6	4.7	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)NCc4ccc(Cl)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	136042340	70807	0	None	21	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	527	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Br)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955916	70807	0	None	21	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	527	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Br)ccc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	46229141	197442	0	None	23	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	614	25	1	10	4.8	C=CCCCCCCCCCCOCCOCCOCCOCCOc1ccc(-c2nc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.bmc.2010.02.014
	CHEMBL589251	197442	0	None	23	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	ChEMBL	614	25	1	10	4.8	C=CCCCCCCCCCCOCCOCCOCCOCCOc1ccc(-c2nc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.bmc.2010.02.014
	44451053	95645	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	597	9	1	7	4.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260221	95645	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	597	9	1	7	4.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	44451285	160713	0	None	31	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	541	5	1	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL412063	160713	0	None	31	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	541	5	1	7	3.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	44451126	166321	0	None	134	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	529	7	1	7	3.6	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL428604	166321	0	None	134	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	529	7	1	7	3.6	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	11690712	77424	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	439	7	3	6	2.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCc4ccccc4)cc3)nc2c1=O	10.1021/jm060277v
	CHEMBL209230	77424	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	439	7	3	6	2.0	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)NCc4ccccc4)cc3)nc2c1=O	10.1021/jm060277v
	44451123	95381	0	None	151	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	570	7	1	8	3.5	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5c(Cl)cncc5Cl)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL258948	95381	0	None	151	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	570	7	1	8	3.5	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5c(Cl)cncc5Cl)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	155562182	175133	0	None	22	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	510	6	3	8	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(O)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4582353	175133	0	None	22	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	510	6	3	8	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(O)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155553575	173605	0	None	75	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	556	7	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)nc2n(CC)c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4547661	173605	0	None	75	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	556	7	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)nc2n(CC)c1=O	10.1021/acs.jmedchem.9b00071
	10970127	120546	0	None	4	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	348	3	2	4	2.3	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(Br)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL35701	120546	0	None	4	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	348	3	2	4	2.3	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(Br)cc3)nc2c1=O	10.1021/jm011049y
	11568359	77832	0	None	2	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	439	6	2	7	1.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)NCCc4ccccc4)cc3)[nH]c2n(C)c1=O	10.1021/jm060277v
	CHEMBL210585	77832	0	None	2	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	439	6	2	7	1.1	Cn1c(=O)c2nc(-c3ccc(S(=O)(=O)NCCc4ccccc4)cc3)[nH]c2n(C)c1=O	10.1021/jm060277v
	69030381	158283	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	529	7	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4094755	158283	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	529	7	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2016.11.007
	69031242	155255	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	520	9	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5cccc(F)c5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4059759	155255	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	520	9	1	8	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5cccc(F)c5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	11663068	72377	0	None	3	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	484	9	2	6	4.0	O=C(COc1ccc(-c2cc3c([nH]2)c(=O)n(CC2CC2)c(=O)n3CC2CC2)cc1)Nc1ccccc1	10.1021/jm0506221
	CHEMBL199862	72377	0	None	3	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	484	9	2	6	4.0	O=C(COc1ccc(-c2cc3c([nH]2)c(=O)n(CC2CC2)c(=O)n3CC2CC2)cc1)Nc1ccccc1	10.1021/jm0506221
	44450849	160746	0	None	33	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	514	8	1	6	4.3	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)N4CCc5ccccc5C4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL412293	160746	0	None	33	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	514	8	1	6	4.3	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)N4CCc5ccccc5C4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	15627855	97842	0	None	9	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	270	3	2	4	1.5	CCCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm0310030
	CHEMBL274855	97842	0	None	9	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	270	3	2	4	1.5	CCCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm0310030
	15627855	97842	0	None	9	3	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	270	3	2	4	1.5	CCCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm011049y
	CHEMBL274855	97842	0	None	9	3	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	270	3	2	4	1.5	CCCn1c(=O)[nH]c2[nH]c(-c3ccccc3)nc2c1=O	10.1021/jm011049y
	11553509	72312	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	418	5	2	6	2.6	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)Nc1ccccc1	10.1021/jm0506221
	CHEMBL199611	72312	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	418	5	2	6	2.6	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)Nc1ccccc1	10.1021/jm0506221
	11649117	140005	0	None	3	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	506	10	2	6	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OC(CC)C(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL381091	140005	0	None	3	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	506	10	2	6	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OC(CC)C(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44451021	95409	0	None	33	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	529	9	1	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259057	95409	0	None	33	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	529	9	1	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	11590537	74640	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	452	6	2	6	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccc(Cl)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL203305	74640	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	452	6	2	6	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccc(Cl)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44451099	95834	0	None	81	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	561	11	1	9	2.2	COCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CCOC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL261212	95834	0	None	81	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	561	11	1	9	2.2	COCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CCOC)c1=O	10.1016/j.bmc.2008.01.002
	57429603	156827	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	484	6	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4078183	156827	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	484	6	1	7	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(F)(F)F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	76314450	105021	0	None	-12	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	343	5	1	7	0.6	CN(C)CCOc1ccc(-c2nc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.ejmech.2014.01.045
	CHEMBL3121720	105021	0	None	-12	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 minsBinding affinity to human recombinant adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated adenylyl cyclase activity after 20 mins	ChEMBL	343	5	1	7	0.6	CN(C)CCOc1ccc(-c2nc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.ejmech.2014.01.045
	126079	4025	20	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm0104318
	451	4025	20	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm0104318
	CHEMBL27041	4025	20	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	10.1021/jm0104318
	10863425	56429	0	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 32-51Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 32-51	ChEMBL	456	4	2	8	4.7	CCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164275	56429	0	None	2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 32-51Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 32-51	ChEMBL	456	4	2	8	4.7	CCn1cc2c(nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	135874430	159571	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	517	8	2	8	3.8	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Cl)c(Cl)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL410895	159571	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	517	8	2	8	3.8	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Cl)c(Cl)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	11596614	76731	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	406	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(C)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL207524	76731	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	406	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(C)cc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL5094532	213715	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(N)nc1-c1cccs1	10.1021/acs.jmedchem.1c01636
	163215620	189739	0	None	-398	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	318	3	2	6	1.8	Nc1nc(C(=O)NCc2ccccn2)cn2c1nc1ccccc12	10.1021/acs.jmedchem.2c00101
	CHEMBL5176737	189739	0	None	-398	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	318	3	2	6	1.8	Nc1nc(C(=O)NCc2ccccn2)cn2c1nc1ccccc12	10.1021/acs.jmedchem.2c00101
	CHEMBL5203105	189739	0	None	-398	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	318	3	2	6	1.8	Nc1nc(C(=O)NCc2ccccn2)cn2c1nc1ccccc12	10.1021/acs.jmedchem.2c00101
	49798161	10640	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	537	6	1	9	3.6	COc1cc(OCc2nc(-c3ccc(Br)cc3)no2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2010.03.011
	CHEMBL1171379	10640	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	537	6	1	9	3.6	COc1cc(OCc2nc(-c3ccc(Br)cc3)no2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.ejmech.2010.03.011
	2748294	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.5b01586
	CHEMBL1490082	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.5b01586
	2748294	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL1490082	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.7b00138
	2748294	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL1490082	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	2748294	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/ml400185v
	CHEMBL1490082	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/ml400185v
	2748294	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL1490082	41121	21	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	264	3	2	4	1.9	CC1=C(C(=O)OC(C)C)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	10661707	161278	0	None	-8	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 343-468Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 343-468	ChEMBL	297	1	1	8	2.1	CC(C)(C)n1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL414620	161278	0	None	-8	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 343-468Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 343-468	ChEMBL	297	1	1	8	2.1	CC(C)(C)n1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	11162618	193820	0	None	-154	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	308	4	2	5	2.6	Cc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)c1	10.1016/j.bmcl.2009.03.142
	CHEMBL553449	193820	0	None	-154	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	308	4	2	5	2.6	Cc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)c1	10.1016/j.bmcl.2009.03.142
	156010620	176451	0	None	-79	2	Human	6.4	pKi	=	6.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	2	6	2.6	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ncc[nH]1	10.1021/acs.jmedchem.0c00564
	CHEMBL4632427	176451	0	None	-79	2	Human	6.4	pKi	=	6.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	2	6	2.6	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ncc[nH]1	10.1021/acs.jmedchem.0c00564
	162665941	181786	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	292	3	2	4	2.5	CC1=C(C(=O)OC2CCC2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4785137	181786	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	292	3	2	4	2.5	CC1=C(C(=O)OC2CCC2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	14969717	202053	0	None	18	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	256	3	2	4	0.7	O=c1[nH]c2[nH]cnc2c(=O)n1CCc1ccccc1	10.1021/jm0104318
	CHEMBL67949	202053	0	None	18	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	256	3	2	4	0.7	O=c1[nH]c2[nH]cnc2c(=O)n1CCc1ccccc1	10.1021/jm0104318
	71681051	89760	0	None	-4	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	338	5	1	4	3.9	Cc1ccc2nc(NC(=O)CCCc3ccccc3)sc(=O)c2c1	10.1021/jm400336x
	CHEMBL2382420	89760	0	None	-4	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	338	5	1	4	3.9	Cc1ccc2nc(NC(=O)CCCc3ccccc3)sc(=O)c2c1	10.1021/jm400336x
	135440168	99480	0	None	23	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	466	9	2	10	1.5	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccncc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL286420	99480	0	None	23	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	466	9	2	10	1.5	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccncc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	66894243	158029	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	493	8	1	8	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4092017	158029	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	493	8	1	8	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	46880373	5845	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	253	3	1	4	2.6	N#Cc1ccc(NC(=O)C2CC2)nc1-c1ccco1	10.1016/j.bmcl.2010.01.045
	CHEMBL1079801	5845	0	None	-3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	253	3	1	4	2.6	N#Cc1ccc(NC(=O)C2CC2)nc1-c1ccco1	10.1016/j.bmcl.2010.01.045
	11656109	77962	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	490	8	1	8	3.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(OC)c(C(F)(F)F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL211038	77962	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	490	8	1	8	3.6	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(OC)c(C(F)(F)F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	9893136	98291	0	None	-19498	6	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	527	5	4	8	2.0	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/jm9905965
	CHEMBL27809	98291	0	None	-19498	6	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	527	5	4	8	2.0	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(I)c4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/jm9905965
	99562	98831	53	None	1	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	218	1	0	6	-0.9	C#CCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1021/jm0104318
	CHEMBL282038	98831	53	None	1	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	218	1	0	6	-0.9	C#CCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1021/jm0104318
	99562	98831	53	None	1	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	218	1	0	6	-0.9	C#CCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL282038	98831	53	None	1	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	218	1	0	6	-0.9	C#CCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1016/j.bmc.2013.09.044
	99562	98831	53	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	218	1	0	6	-0.9	C#CCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1016/j.bmc.2013.09.044
	CHEMBL282038	98831	53	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptorDisplacement of [3H]PSB-603 from human adenosine A2B receptor	ChEMBL	218	1	0	6	-0.9	C#CCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1016/j.bmc.2013.09.044
	1922	201121	39	None	-26	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm0104318
	CHEMBL62350	201121	39	None	-26	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm0104318
	1922	201121	39	None	-26	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranesBinding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm0310030
	CHEMBL62350	201121	39	None	-26	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranesBinding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes	ChEMBL	256	1	1	5	0.6	Cn1c(=O)c2nc(-c3ccccc3)[nH]c2n(C)c1=O	10.1021/jm0310030
	47104774	103359	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	296	3	2	4	2.5	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=S)N1	10.1021/ml400185v
	CHEMBL3091705	103359	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	296	3	2	4	2.5	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=S)N1	10.1021/ml400185v
	21958526	130173	0	None	-6	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5cccc(Cl)c5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL368442	130173	0	None	-6	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5cccc(Cl)c5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	46880420	6249	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	322	4	1	5	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2nccs2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1082006	6249	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	322	4	1	5	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2nccs2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	90654601	109533	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PSB603 from human adenosine A2B receptor expressed in CHO cell membranes after 2 hrs by beta scintillation counting analysisDisplacement of [3H]PSB603 from human adenosine A2B receptor expressed in CHO cell membranes after 2 hrs by beta scintillation counting analysis	ChEMBL	369	4	1	9	3.1	N#Cc1c(N)nc(SCc2cscn2)nc1-c1ccc2c(c1)OCO2	10.1021/jm401643m
	CHEMBL3234965	109533	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PSB603 from human adenosine A2B receptor expressed in CHO cell membranes after 2 hrs by beta scintillation counting analysisDisplacement of [3H]PSB603 from human adenosine A2B receptor expressed in CHO cell membranes after 2 hrs by beta scintillation counting analysis	ChEMBL	369	4	1	9	3.1	N#Cc1c(N)nc(SCc2cscn2)nc1-c1ccc2c(c1)OCO2	10.1021/jm401643m
	44406617	72276	0	None	22	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5cccc(C(F)(F)F)c5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL199471	72276	0	None	22	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5cccc(C(F)(F)F)c5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11420226	95890	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	7	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cc(-c5ccc(Cl)cc5)on4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL261554	95890	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	7	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(Cc4cc(-c5ccc(Cl)cc5)on4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	24828056	155955	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	288	3	2	6	0.5	CC(C)Cn1c(=O)c2[nH]c(-c3cn[nH]c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL406775	155955	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	288	3	2	6	0.5	CC(C)Cn1c(=O)c2[nH]c(-c3cn[nH]c3)nc2n(C)c1=O	10.1021/jm7014815
	9970296	119950	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	269	3	2	3	2.1	CCCn1c(=O)[nH]c2cc(-c3ccccc3)[nH]c2c1=O	10.1021/jm011049y
	CHEMBL35415	119950	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	269	3	2	3	2.1	CCCn1c(=O)[nH]c2cc(-c3ccccc3)[nH]c2c1=O	10.1021/jm011049y
	155555919	173842	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4552910	173842	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	11278089	84271	5	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	303	4	1	3	4.2	CCC(=O)Nc1nc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm100843z
	CHEMBL222718	84271	5	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	303	4	1	3	4.2	CCC(=O)Nc1nc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm100843z
	11568517	74132	0	None	20	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	446	7	1	6	2.7	CCN(Cc1ccccc1)C(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1021/jm0506221
	CHEMBL202876	74132	0	None	20	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	446	7	1	6	2.7	CCN(Cc1ccccc1)C(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1021/jm0506221
	44574281	177951	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	547	8	1	7	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL466828	177951	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	547	8	1	7	4.6	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	14969715	202088	1	None	-91	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	208	3	2	4	0.2	CCCCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	CHEMBL68278	202088	1	None	-91	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	208	3	2	4	0.2	CCCCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	9858577	178086	0	None	-13	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	327	3	1	8	2.1	Nc1nc(-c2cncs2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	CHEMBL467867	178086	0	None	-13	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	327	3	1	8	2.1	Nc1nc(-c2cncs2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	76331767	103357	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	3	1	4	1.8	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091702	103357	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	3	1	4	1.8	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	76331767	103357	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	3	1	4	1.8	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccoc1	10.1021/ml400185v
	CHEMBL3091702	103357	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	3	1	4	1.8	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccoc1	10.1021/ml400185v
	162672711	182637	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	276	4	2	4	1.9	CC1=C(C(=O)OCC2CC2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4796169	182637	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	276	4	2	4	1.9	CC1=C(C(=O)OCC2CC2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	44452514	95363	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	323	6	1	7	3.0	COCCCNc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	CHEMBL258848	95363	0	None	-5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	323	6	1	7	3.0	COCCCNc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	10834513	38547	0	None	-12	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 3828-4817Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 3828-4817	ChEMBL	395	4	1	8	3.7	Nc1nc2nn(CCc3cccc4ccccc34)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL146658	38547	0	None	-12	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 3828-4817Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 3828-4817	ChEMBL	395	4	1	8	3.7	Nc1nc2nn(CCc3cccc4ccccc34)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	11420910	96478	0	None	-9	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	513	9	1	10	3.0	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)Oc4cccc([N+](=O)[O-])c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0310030
	CHEMBL266099	96478	0	None	-9	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	513	9	1	10	3.0	CCCn1c(=O)c2nc(-c3ccc(S(=O)(=O)Oc4cccc([N+](=O)[O-])c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0310030
	66894271	156906	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	493	8	1	8	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5cccc(F)c5)C4=O)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4079189	156906	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	493	8	1	8	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5cccc(F)c5)C4=O)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	53325341	57702	0	None	14	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	4	1	6	2.5	O=C(Nc1cnc(-c2ccncc2)c(-c2cnco2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672625	57702	0	None	14	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	4	1	6	2.5	O=C(Nc1cnc(-c2ccncc2)c(-c2cnco2)n1)C1CC1	10.1021/ml100249e
	21874661	189869	0	None	-60	4	Human	7.4	pKi	=	7.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	325	3	2	8	1.8	Nc1nc(-c2ccco2)c2nnn(Cc3ccc(N)c(F)c3)c2n1	10.1021/jm800961g
	CHEMBL517886	189869	0	None	-60	4	Human	7.4	pKi	=	7.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	325	3	2	8	1.8	Nc1nc(-c2ccco2)c2nnn(Cc3ccc(N)c(F)c3)c2n1	10.1021/jm800961g
	76324530	103355	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	266	3	2	4	1.6	CCOC(=O)C1=C(C)NC(=S)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091700	103355	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	266	3	2	4	1.6	CCOC(=O)C1=C(C)NC(=S)NC1c1ccoc1	10.1021/acs.jmedchem.0c01431
	76324530	103355	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	266	3	2	4	1.6	CCOC(=O)C1=C(C)NC(=S)NC1c1ccoc1	10.1021/ml400185v
	CHEMBL3091700	103355	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	266	3	2	4	1.6	CCOC(=O)C1=C(C)NC(=S)NC1c1ccoc1	10.1021/ml400185v
	44451790	95529	0	None	-24	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	316	2	1	6	3.0	N#Cc1c(-c2ccccc2)nc(N)nc1-c1ccc2c(c1)OCO2	10.1021/acs.jmedchem.1c01636
	CHEMBL259607	95529	0	None	-24	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	316	2	1	6	3.0	N#Cc1c(-c2ccccc2)nc(N)nc1-c1ccc2c(c1)OCO2	10.1021/acs.jmedchem.1c01636
	156019165	177412	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2cocn2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4646279	177412	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2cocn2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL5082650	213033	0	None	-10	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL		None	None	None		Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCCN3CCCCC3)ccc1C2=O	10.1021/acs.jmedchem.0c00914
	11595592	71951	0	None	93	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	357	6	2	6	1.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL198345	71951	0	None	93	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	357	6	2	6	1.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11611016	72335	0	None	22	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	399	8	2	6	2.8	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199697	72335	0	None	22	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	399	8	2	6	2.8	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)O)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44451224	158829	0	None	6	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	474	5	1	7	2.2	COc1cc(OCC(=O)N2CCc3ccccc3C2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	CHEMBL410066	158829	0	None	6	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	474	5	1	7	2.2	COc1cc(OCC(=O)N2CCc3ccccc3C2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	11143352	198455	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	378	6	0	7	2.5	CCCn1c(=O)c2c(nc(Cc3ccccc3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL596346	198455	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	378	6	0	7	2.5	CCCn1c(=O)c2c(nc(Cc3ccccc3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	9950776	82770	0	None	-707	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	360	5	2	6	2.0	CCCn1c(=O)c2nc(C34CCC(O)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm060539t
	CHEMBL218458	82770	0	None	-707	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	360	5	2	6	2.0	CCCn1c(=O)c2nc(C34CCC(O)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm060539t
	21958522	64349	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5C)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL181873	64349	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5C)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	44588439	174972	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	327	5	2	5	2.7	CCCn1c(=O)c2[nH]c(-c3ccc(O)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457881	174972	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	327	5	2	5	2.7	CCCn1c(=O)c2[nH]c(-c3ccc(O)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	11611580	77839	0	None	8	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	424	7	1	7	3.1	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(C)c4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210609	77839	0	None	8	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	424	7	1	7	3.1	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(C)c4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	2690	888	59	None	-30	9	Human	7.4	pKi	=	7.4	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm4011669
	384	888	59	None	-30	9	Human	7.4	pKi	=	7.4	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm4011669
	CHEMBL16687	888	59	None	-30	9	Human	7.4	pKi	=	7.4	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm4011669
	11663050	140546	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3cccc(OCC(=O)Nc4ccc(Br)cc4)c3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL382663	140546	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	482	5	2	6	3.0	Cn1c(=O)c2[nH]c(-c3cccc(OCC(=O)Nc4ccc(Br)cc4)c3)cc2n(C)c1=O	10.1021/jm0506221
	24950846	169934	0	None	-28	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	265	2	1	5	3.4	Cc1ccc(-c2cc(-c3ccco3)nc(N)c2C#N)o1	10.1021/jm701594y
	CHEMBL444953	169934	0	None	-28	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	265	2	1	5	3.4	Cc1ccc(-c2cc(-c3ccco3)nc(N)c2C#N)o1	10.1021/jm701594y
	21874692	188209	0	None	-15	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	337	4	1	9	2.0	Nc1nc(-c2ccco2)c2nnn(Cc3ccc([N+](=O)[O-])cc3)c2n1	10.1021/jm800961g
	CHEMBL505977	188209	0	None	-15	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	337	4	1	9	2.0	Nc1nc(-c2ccco2)c2nnn(Cc3ccc([N+](=O)[O-])cc3)c2n1	10.1021/jm800961g
	142609112	181548	0	None	-131	4	Human	6.4	pKi	=	6.4	Binding	Inhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assayInhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assay	ChEMBL	309	4	2	6	2.0	Cc1cccnc1CNC(=O)c1cnc(-c2ccco2)nc1N	10.1021/acs.jmedchem.0c00237
	CHEMBL4782266	181548	0	None	-131	4	Human	6.4	pKi	=	6.4	Binding	Inhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assayInhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assay	ChEMBL	309	4	2	6	2.0	Cc1cccnc1CNC(=O)c1cnc(-c2ccco2)nc1N	10.1021/acs.jmedchem.0c00237
	21874764	188612	0	None	-3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	349	4	2	8	2.1	CC(=O)Nc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	CHEMBL511413	188612	0	None	-3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	349	4	2	8	2.1	CC(=O)Nc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	11808022	182971	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	2	2	4	2.2	CC1=C(C(=O)OC(C)(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4800327	182971	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	2	2	4	2.2	CC1=C(C(=O)OC(C)(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	11289861	193611	0	None	-63	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	310	4	3	7	1.2	Nc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL551373	193611	0	None	-63	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	310	4	3	7	1.2	Nc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)n1	10.1016/j.bmcl.2009.03.142
	4314924	177233	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	322	3	2	5	3.2	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cc[nH]c1	10.1021/acs.jmedchem.0c00564
	CHEMBL4643705	177233	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	322	3	2	5	3.2	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cc[nH]c1	10.1021/acs.jmedchem.0c00564
	11091600	82893	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	449	6	1	10	3.2	COc1ccc(CC(=O)Nc2nc3nn(C)c(SC)c3c3nc(-c4ccco4)nn23)cc1	10.1021/jm021023m
	CHEMBL21910	82893	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	449	6	1	10	3.2	COc1ccc(CC(=O)Nc2nc3nn(C)c(SC)c3c3nc(-c4ccco4)nn23)cc1	10.1021/jm021023m
	24827552	95769	0	None	6	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	379	5	1	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(-c4ccc(C)nc4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL260878	95769	0	None	6	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	379	5	1	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(-c4ccc(C)nc4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL5088876	213400	0	None	-25	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		COc1cc(OC)cc(-c2nc(N)nc(-c3ccccc3)c2C#N)c1	10.1021/acs.jmedchem.1c01636
	11508721	71907	0	None	16	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	357	6	2	6	1.6	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc21	10.1021/jm0506221
	CHEMBL198243	71907	0	None	16	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	357	6	2	6	1.6	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc21	10.1021/jm0506221
	9890003	118893	0	None	-5	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 432-469Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 432-469	ChEMBL	450	3	2	8	4.8	CC(C)(C)n1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL344724	118893	0	None	-5	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 432-469Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 432-469	ChEMBL	450	3	2	8	4.8	CC(C)(C)n1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	145981689	166018	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	579	14	1	10	2.6	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCN3CCCC3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	CHEMBL4280069	166018	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	579	14	1	10	2.6	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCN3CCCC3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	44390551	167765	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	511	9	1	10	3.9	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(C#N)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL434334	167765	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	511	9	1	10	3.9	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(C#N)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	2882256	31677	11	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	342	4	1	4	3.5	CC1=C(C(=O)OCc2ccccc2)C(c2ccsc2)NC(=O)N1C	10.1021/acs.jmedchem.0c01431
	CHEMBL1407320	31677	11	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	342	4	1	4	3.5	CC1=C(C(=O)OCc2ccccc2)C(c2ccsc2)NC(=O)N1C	10.1021/acs.jmedchem.0c01431
	12267228	176352	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	269	1	1	4	1.5	Cc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.bmc.2008.09.067
	CHEMBL462095	176352	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	269	1	1	4	1.5	Cc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1016/j.bmc.2008.09.067
	10938608	119593	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 34-62Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 34-62	ChEMBL	416	5	2	8	4.1	CCCn1cc2c(nc(NC(=O)Nc3ccc(C)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL351075	119593	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 34-62Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 34-62	ChEMBL	416	5	2	8	4.1	CCCn1cc2c(nc(NC(=O)Nc3ccc(C)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	24827443	95883	0	None	8	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	365	5	1	8	1.6	CCCn1c(=O)c2[nH]c(-c3cnn(-c4ccccn4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL261525	95883	0	None	8	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	365	5	1	8	1.6	CCCn1c(=O)c2[nH]c(-c3cnn(-c4ccccn4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	21874686	176235	0	None	-30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	307	3	2	8	1.7	Nc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	CHEMBL460975	176235	0	None	-30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	307	3	2	8	1.7	Nc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	136044105	119533	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	358	6	2	7	2.1	CCCn1c(=O)c2[nH]c(-c3ccc(OC)cc3O)nc2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL350469	119533	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	358	6	2	7	2.1	CCCn1c(=O)c2[nH]c(-c3ccc(OC)cc3O)nc2n(CCC)c1=O	10.1021/jm0104318
	46228004	198364	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	426	6	0	7	2.8	Cn1c(Cc2c(F)cccc2F)nc2c1c(=O)n(CC1CC1)c(=O)n2Cc1ccco1	10.1016/j.bmc.2009.07.034
	CHEMBL595657	198364	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	426	6	0	7	2.8	Cn1c(Cc2c(F)cccc2F)nc2c1c(=O)n(CC1CC1)c(=O)n2Cc1ccco1	10.1016/j.bmc.2009.07.034
	11739282	194973	0	None	-269	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	339	6	2	7	1.8	COCc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL564473	194973	0	None	-269	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	339	6	2	7	1.8	COCc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)n1	10.1016/j.bmcl.2009.03.142
	11739282	194973	0	None	-269	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	339	6	2	7	1.8	COCc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)n1	10.1021/jm4011669
	CHEMBL564473	194973	0	None	-269	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	339	6	2	7	1.8	COCc1cccc(CNC(=O)c2cc(-c3ccco3)nc(N)n2)n1	10.1021/jm4011669
	14969716	201888	2	None	32	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	192	2	2	4	-0.4	C=CCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	CHEMBL66899	201888	2	None	32	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	192	2	2	4	-0.4	C=CCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	137650340	156966	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	290	3	2	5	1.7	CCOC(=O)C1=C(C)N/C(=N\C#N)NC1c1ccsc1	10.1021/acs.jmedchem.7b00138
	CHEMBL4079899	156966	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	290	3	2	5	1.7	CCOC(=O)C1=C(C)N/C(=N\C#N)NC1c1ccsc1	10.1021/acs.jmedchem.7b00138
	49870828	18589	0	None	-54	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins	ChEMBL	373	3	0	7	3.5	Cc1nn(Cc2ccccc2)c(=O)c2ncn3nc(-c4ccsc4)cc3c12	10.1016/j.bmc.2010.09.043
	CHEMBL1278102	18589	0	None	-54	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins	ChEMBL	373	3	0	7	3.5	Cc1nn(Cc2ccccc2)c(=O)c2ncn3nc(-c4ccsc4)cc3c12	10.1016/j.bmc.2010.09.043
	135465785	485	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	439	485	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL32582	485	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	135465785	485	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	439	485	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL32582	485	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	46880508	6063	0	None	18	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	4	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2ccccn2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081039	6063	0	None	18	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	316	4	1	4	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2ccccn2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	46880332	6137	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	280	3	1	5	2.8	CC(=O)Nc1ccc(-c2ccncn2)c(-c2ccco2)n1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081459	6137	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	280	3	1	5	2.8	CC(=O)Nc1ccc(-c2ccncn2)c(-c2ccco2)n1	10.1016/j.bmcl.2010.01.045
	CHEMBL5082920	213050	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL		None	None	None		Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCCN3CCCC3)ccc1C2=O	10.1021/acs.jmedchem.0c00914
	CHEMBL5083244	213072	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		CNc1nc(-c2ccccc2)c(C#N)c(-c2ccccc2F)n1	10.1021/acs.jmedchem.1c01636
	1676	98514	53	None	-3	10	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1016/j.ejmech.2016.11.007
	CHEMBL279898	98514	53	None	-3	10	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1016/j.ejmech.2016.11.007
	1676	98514	53	None	-3	10	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1021/jm0104318
	CHEMBL279898	98514	53	None	-3	10	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1021/jm0104318
	1676	98514	53	None	-3	10	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]DPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [3H]DPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1021/acs.jmedchem.5b01586
	CHEMBL279898	98514	53	None	-3	10	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]DPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [3H]DPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1021/acs.jmedchem.5b01586
	1676	98514	53	None	-3	10	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1021/jm051268+
	CHEMBL279898	98514	53	None	-3	10	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1021/jm051268+
	65269	187634	27	None	-21	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	265	2	4	8	-1.3	Nc1ncnc2c1ncn2[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm9905965
	CHEMBL49935	187634	27	None	-21	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	265	2	4	8	-1.3	Nc1ncnc2c1ncn2[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O	10.1021/jm9905965
	CHEMBL5091545	213529	0	None	-16	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		CNc1nc(-c2ccccc2)c(C#N)c(-c2ccc(C)cc2)n1	10.1021/acs.jmedchem.1c01636
	44451105	160074	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	537	6	1	8	2.6	COc1cc(OCC(=O)N2CCN(c3ccc(Cl)cc3)CC2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	CHEMBL411314	160074	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	537	6	1	8	2.6	COc1cc(OCC(=O)N2CCN(c3ccc(Cl)cc3)CC2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	46233214	198583	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	344	6	1	6	2.3	CCSCCn1c(=O)n(CC)c(=O)c2[nH]c(-c3ccccc3)nc21	10.1016/j.bmc.2010.01.028
	CHEMBL597169	198583	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	344	6	1	6	2.3	CCSCCn1c(=O)n(CC)c(=O)c2[nH]c(-c3ccccc3)nc21	10.1016/j.bmc.2010.01.028
	44588473	174662	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	357	6	1	7	2.7	CCCn1c(=O)c2c(cc(-c3ccc(OC)cc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457209	174662	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	357	6	1	7	2.7	CCCn1c(=O)c2c(cc(-c3ccc(OC)cc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	404	4023	30	None	-229	11	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human Adenosine A2B receptorBinding affinity towards human Adenosine A2B receptor	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/jm011049y
	432	4023	30	None	-229	11	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human Adenosine A2B receptorBinding affinity towards human Adenosine A2B receptor	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/jm011049y
	5697	4023	30	None	-229	11	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human Adenosine A2B receptorBinding affinity towards human Adenosine A2B receptor	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/jm011049y
	CHEMBL273094	4023	30	None	-229	11	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human Adenosine A2B receptorBinding affinity towards human Adenosine A2B receptor	ChEMBL	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10.1021/jm011049y
	57429621	158616	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	418	5	3	7	1.4	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4098369	158616	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	418	5	3	7	1.4	CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)[nH]c2c1=O	10.1016/j.ejmech.2017.04.014
	22266756	94145	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	464	6	2	9	2.4	O=c1[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	CHEMBL252074	94145	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	464	6	2	9	2.4	O=c1[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	11112849	56991	0	None	-177	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 37-63Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 37-63	ChEMBL	432	4	2	10	3.1	CCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL165083	56991	0	None	-177	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 37-63Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 37-63	ChEMBL	432	4	2	10	3.1	CCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	135874421	168381	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	477	8	2	8	3.1	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(C)c(C)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL438938	168381	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	477	8	2	8	3.1	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(C)c(C)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	11466670	72559	0	None	25	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	527	8	1	9	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccc(C(F)(F)F)cc5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200451	72559	0	None	25	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	527	8	1	9	4.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccc(C(F)(F)F)cc5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	52946584	200131	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]PSB-298 binding to adenosine A2b receptorInhibition of [3H]PSB-298 binding to adenosine A2b receptor	ChEMBL	496	7	3	6	3.5	CCCC1C(=O)Nc2nc(-c3ccc(OCC(=O)NC4CC(C)(C)N([O])C(C)(C)C4)cc3)[nH]c2C1=O	10.1021/jm049513x
	CHEMBL607025	200131	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]PSB-298 binding to adenosine A2b receptorInhibition of [3H]PSB-298 binding to adenosine A2b receptor	ChEMBL	496	7	3	6	3.5	CCCC1C(=O)Nc2nc(-c3ccc(OCC(=O)NC4CC(C)(C)N([O])C(C)(C)C4)cc3)[nH]c2C1=O	10.1021/jm049513x
	155524516	170390	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	432	5	2	7	0.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(C)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4455937	170390	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	432	5	2	7	0.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(C)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	45268873	195065	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	532	10	2	9	2.1	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NN4CCc5ccccc5C4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL565192	195065	0	None	2	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	532	10	2	9	2.1	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NN4CCc5ccccc5C4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	136042335	70803	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	490	8	2	10	1.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc(=O)c5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955911	70803	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	490	8	2	10	1.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc(=O)c5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	168273637	189712	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	410	7	1	8	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(OS(=O)(=O)F)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5176227	189712	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	410	7	1	8	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(OS(=O)(=O)F)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	168272084	189678	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	369	6	1	7	3.1	CCCn1c(=O)c2[nH]c(-c3cccc(N=C=S)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5175698	189678	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	369	6	1	7	3.1	CCCn1c(=O)c2[nH]c(-c3cccc(N=C=S)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	11662264	76915	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	444	7	1	7	3.4	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(F)ccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL208143	76915	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	444	7	1	7	3.4	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(F)ccc4Cl)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	2980395	138465	13	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cccs1	10.1021/acs.jmedchem.0c00564
	CHEMBL3785635	138465	13	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cccs1	10.1021/acs.jmedchem.0c00564
	2980395	138465	13	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cccs1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785635	138465	13	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cccs1	10.1021/acs.jmedchem.5b01586
	2980395	138465	13	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cccs1	10.1021/acs.jmedchem.9b01340
	CHEMBL3785635	138465	13	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	339	3	1	6	4.0	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cccs1	10.1021/acs.jmedchem.9b01340
	44390528	122086	0	None	2	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(C(F)(F)F)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL360280	122086	0	None	2	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(C(F)(F)F)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	52941244	19040	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	509	9	2	5	5.7	C[C@@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290209	19040	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	509	9	2	5	5.7	C[C@@H](NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	45273099	193943	0	None	10	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	378	9	1	8	1.9	CCSCCn1c(=O)c2[nH]c(-c3ccco3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL556264	193943	0	None	10	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	378	9	1	8	1.9	CCSCCn1c(=O)c2[nH]c(-c3ccco3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	10219934	95828	7	None	1	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	208	1	1	5	0.0	CC(C)n1c(=O)n(C)c(=O)c2[nH]cnc21	10.1021/jm0104318
	CHEMBL26119	95828	7	None	1	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	208	1	1	5	0.0	CC(C)n1c(=O)n(C)c(=O)c2[nH]cnc21	10.1021/jm0104318
	10737168	164772	0	None	-288	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 38-63Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 38-63	ChEMBL	359	5	1	8	2.9	Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL423542	164772	0	None	-288	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 38-63Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 38-63	ChEMBL	359	5	1	8	2.9	Nc1nc2nn(CCCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	50940980	56974	2	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	283	4	1	5	3.3	CCC(=O)Nc1cc(-c2ccoc2)nc(-c2ccoc2)n1	10.1021/jm100843z
	CHEMBL1650391	56974	2	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	283	4	1	5	3.3	CCC(=O)Nc1cc(-c2ccoc2)nc(-c2ccoc2)n1	10.1021/jm100843z
	136042335	70803	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	490	8	2	10	1.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc(=O)c5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955911	70803	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	490	8	2	10	1.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc(=O)c5ccccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	21958762	155227	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	288	4	2	6	0.7	CCCn1c(=O)c2[nH]c(-c3cn[nH]c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL405901	155227	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	288	4	2	6	0.7	CCCn1c(=O)c2[nH]c(-c3cn[nH]c3)nc2n(CC)c1=O	10.1021/jm7014815
	155511760	169032	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC(C)OC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.9b01340
	CHEMBL4436567	169032	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC(C)OC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccoc1	10.1021/acs.jmedchem.9b01340
	122227309	177080	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	322	3	2	5	3.2	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccc[nH]1	10.1021/acs.jmedchem.0c00564
	CHEMBL4641601	177080	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	322	3	2	5	3.2	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccc[nH]1	10.1021/acs.jmedchem.0c00564
	44588472	172033	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	341	6	1	5	3.0	CCCn1c(=O)c2[nH]c(-c3ccc(OC)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL449133	172033	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	341	6	1	5	3.0	CCCn1c(=O)c2[nH]c(-c3ccc(OC)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL5075422	212591	2	None	-87	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H] DPCPX from human recombinant A2B adenosine receptor expressed in HEK293 cells incubated for 30 mins by radioligand binding competition assayDisplacement of [3H] DPCPX from human recombinant A2B adenosine receptor expressed in HEK293 cells incubated for 30 mins by radioligand binding competition assay	ChEMBL		None	None	None		Cn1cc(-c2cnc(N)n3nc(-c4ccco4)nc23)ccc1=O	10.1021/acsmedchemlett.1c00599
	71570366	85710	0	None	-11	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK-293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK-293 cells	ChEMBL	409	7	1	7	3.8	COc1cccc(-c2cc(NC(C)=O)nc(-c3cccc(OC)c3OC)n2)c1OC	10.1016/j.ejmech.2012.11.010
	CHEMBL2311745	85710	0	None	-11	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK-293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK-293 cells	ChEMBL	409	7	1	7	3.8	COc1cccc(-c2cc(NC(C)=O)nc(-c3cccc(OC)c3OC)n2)c1OC	10.1016/j.ejmech.2012.11.010
	44236567	156748	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	430	6	1	7	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4077090	156748	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	430	6	1	7	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	44236420	155682	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	518	8	1	9	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(C)cc5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4064755	155682	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	518	8	1	9	2.2	CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(C)cc5)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	21958775	94322	0	None	19	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	380	5	2	6	1.9	O=c1[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	CHEMBL253252	94322	0	None	19	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	380	5	2	6	1.9	O=c1[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	10246959	58441	0	None	-15	6	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	345	4	1	8	2.6	Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	CHEMBL16867	58441	0	None	-15	6	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	345	4	1	8	2.6	Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm030852k
	46880375	5847	0	None	29	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	339	4	1	4	4.4	O=C(Nc1ccc(-c2ccncc2Cl)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1079803	5847	0	None	29	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	339	4	1	4	4.4	O=C(Nc1ccc(-c2ccncc2Cl)c(-c2ccco2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	46880419	6248	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	319	4	1	4	4.1	Cc1ccc(-c2nc(NC(=O)C3CC3)ccc2-c2ccncc2)o1	10.1016/j.bmcl.2010.01.045
	CHEMBL1082005	6248	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	319	4	1	4	4.1	Cc1ccc(-c2nc(NC(=O)C3CC3)ccc2-c2ccncc2)o1	10.1016/j.bmcl.2010.01.045
	136042350	70791	0	None	30	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	496	8	2	9	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955899	70791	0	None	30	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	496	8	2	9	3.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	11610638	165630	0	None	57	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	382	5	1	7	2.0	CCn1c(=O)c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2n(CC)c1=O	10.1021/jm7014815
	CHEMBL426504	165630	0	None	57	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	382	5	1	7	2.0	CCn1c(=O)c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2n(CC)c1=O	10.1021/jm7014815
	53248700	60395	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	536	5	2	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)N3CCC(O)(c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1760899	60395	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	536	5	2	6	5.2	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)N3CCC(O)(c4cccc(C(F)(F)F)c4)CC3)sc12	10.1016/j.bmcl.2011.02.053
	11610638	165630	0	None	57	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	382	5	1	7	2.0	CCn1c(=O)c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2n(CC)c1=O	10.1021/jm051268+
	CHEMBL426504	165630	0	None	57	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	382	5	1	7	2.0	CCn1c(=O)c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2n(CC)c1=O	10.1021/jm051268+
	10246959	58441	0	None	-15	6	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 3.9-6.7Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 3.9-6.7	ChEMBL	345	4	1	8	2.6	Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL16867	58441	0	None	-15	6	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 3.9-6.7Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 3.9-6.7	ChEMBL	345	4	1	8	2.6	Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	11576491	74084	0	None	20	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	474	9	2	6	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL202766	74084	0	None	20	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	474	9	2	6	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11497055	74085	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	504	10	2	7	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)Nc4ccc(OC)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL202767	74085	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	504	10	2	7	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)Nc4ccc(OC)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11649145	134668	0	None	1	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	508	8	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(-c5ccccc5)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL372148	134668	0	None	1	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	508	8	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(-c5ccccc5)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44451283	96003	0	None	20	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	473	5	1	7	2.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL262332	96003	0	None	20	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	473	5	1	7	2.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	44236539	156239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	460	7	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4070936	156239	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	460	7	2	8	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(C(=O)O)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	71452718	78498	0	None	7	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241380 binding to adenosine A2b receptorInhibition of [3H]ZM-241380 binding to adenosine A2b receptor	ChEMBL	491	10	4	7	2.5	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC(=O)O)cc4)cc3)nc2c1=O	10.1021/jm049513x
	CHEMBL2112962	78498	0	None	7	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241380 binding to adenosine A2b receptorInhibition of [3H]ZM-241380 binding to adenosine A2b receptor	ChEMBL	491	10	4	7	2.5	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC(=O)O)cc4)cc3)nc2c1=O	10.1021/jm049513x
	10863910	140295	0	None	7	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	491	9	3	8	2.7	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)OC)cc4)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL38193	140295	0	None	7	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	491	9	3	8	2.7	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)OC)cc4)cc3)nc2c1=O	10.1021/jm011049y
	10050439	204603	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	471	7	2	9	2.2	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Oc4ccc([N+](=O)[O-])cc4)cc3)nc2c1=O	10.1021/jm0310030
	CHEMBL8732	204603	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]-PSB-298 in CHO cell membranes	ChEMBL	471	7	2	9	2.2	CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Oc4ccc([N+](=O)[O-])cc4)cc3)nc2c1=O	10.1021/jm0310030
	57988776	156106	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	519	9	1	7	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(F)cc5)C4)cc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4069458	156106	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	519	9	1	7	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(F)cc5)C4)cc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	162650047	179478	0	None	-69	2	Human	8.3	pKi	=	8.3	Binding	Inhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assayInhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assay	ChEMBL	393	5	2	7	3.0	COc1nc(-c2ncco2)nc(N)c1C(=O)NCc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.0c00237
	CHEMBL4747929	179478	0	None	-69	2	Human	8.3	pKi	=	8.3	Binding	Inhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assayInhibition of FRET-labelled CA200645 binding to human adenosine 2B receptor expressed in CHO cells incubated for 2 hr by TR-FRET assay	ChEMBL	393	5	2	7	3.0	COc1nc(-c2ncco2)nc(N)c1C(=O)NCc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.0c00237
	44185934	186118	0	None	14	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	403	4	2	6	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCCCC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL488542	186118	0	None	14	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	403	4	2	6	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCCCC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	168297138	191633	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	368	5	2	7	1.1	CCCn1c(=O)[nH]c2nc(-c3ccc(OS(=O)(=O)F)cc3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5205220	191633	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	368	5	2	7	1.1	CCCn1c(=O)[nH]c2nc(-c3ccc(OS(=O)(=O)F)cc3)[nH]c2c1=O	10.1039/d2md00132b
	135484064	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	390	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	CHEMBL260331	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	135484064	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	390	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	CHEMBL260331	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm0309654
	135484064	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm900413e
	390	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm900413e
	CHEMBL260331	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm900413e
	135484064	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/acs.jmedchem.5b01586
	390	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/acs.jmedchem.5b01586
	CHEMBL260331	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 minsDisplacement of [3H] DPCPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 60 mins	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/acs.jmedchem.5b01586
	44236601	157027	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(OC(F)(F)F)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4080646	157027	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	500	7	1	8	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(OC(F)(F)F)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	44450982	100493	0	None	120	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	576	8	1	6	5.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL294223	100493	0	None	120	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	576	8	1	6	5.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	135484064	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine receptor A2b expressed in HEK293 cell membranesDisplacement of [3H]DPCPX from human adenosine receptor A2b expressed in HEK293 cell membranes	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2016.11.007
	390	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine receptor A2b expressed in HEK293 cell membranesDisplacement of [3H]DPCPX from human adenosine receptor A2b expressed in HEK293 cell membranes	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2016.11.007
	CHEMBL260331	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine receptor A2b expressed in HEK293 cell membranesDisplacement of [3H]DPCPX from human adenosine receptor A2b expressed in HEK293 cell membranes	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.ejmech.2016.11.007
	135484064	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	390	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	CHEMBL260331	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	135484064	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	390	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	CHEMBL260331	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1021/jm201292w
	136042343	70810	0	None	11	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	501	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)c(F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955919	70810	0	None	11	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	501	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(Cl)c(F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	135484064	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.bmc.2007.11.058
	390	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.bmc.2007.11.058
	CHEMBL260331	2568	3	None	21	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	10.1016/j.bmc.2007.11.058
	10895702	138637	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241380 binding to adenosine A2b receptorInhibition of [3H]ZM-241380 binding to adenosine A2b receptor	ChEMBL	454	8	2	7	1.4	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(CC)CC4)cc3)nc2c1=O	10.1021/jm049513x
	CHEMBL37875	138637	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241380 binding to adenosine A2b receptorInhibition of [3H]ZM-241380 binding to adenosine A2b receptor	ChEMBL	454	8	2	7	1.4	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(CC)CC4)cc3)nc2c1=O	10.1021/jm049513x
	10895702	138637	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	454	8	2	7	1.4	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(CC)CC4)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL37875	138637	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	454	8	2	7	1.4	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(CC)CC4)cc3)nc2c1=O	10.1021/jm011049y
	11510702	72756	0	None	11	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	450	7	2	6	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL201127	72756	0	None	11	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	450	7	2	6	3.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44450982	100493	0	None	120	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	576	8	1	6	5.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL294223	100493	0	None	120	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	576	8	1	6	5.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	155552405	173473	0	None	25	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	522	6	2	7	1.6	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(C(=O)c5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4543948	173473	0	None	25	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	522	6	2	7	1.6	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(C(=O)c5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44451100	156332	0	None	109	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	592	7	1	9	4.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL407202	156332	0	None	109	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	592	7	1	9	4.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5nc6ccc(Cl)cc6s5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	11621020	72434	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	558	7	2	6	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL200052	72434	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	558	7	2	6	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(I)cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44236503	157503	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	434	6	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(F)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4086077	157503	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	434	6	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(F)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	44574252	177897	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	450	8	3	7	3.5	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4cc[nH]n4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL466453	177897	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	450	8	3	7	3.5	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4cc[nH]n4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	145967791	164259	0	None	10	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	659	12	3	7	5.0	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4218673	164259	0	None	10	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	659	12	3	7	5.0	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	10196114	63627	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(OC)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL180693	63627	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(OC)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	135465774	110978	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	467	8	2	8	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(F)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32770	110978	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	467	8	2	8	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(F)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135465774	110978	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	467	8	2	8	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(F)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32770	110978	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	467	8	2	8	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(F)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10196114	63627	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(OC)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL180693	63627	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(OC)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm201292w
	10905799	119392	0	None	-7	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 43-58Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 43-58	ChEMBL	416	6	2	8	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL349240	119392	0	None	-7	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 43-58Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 43-58	ChEMBL	416	6	2	8	4.2	CCCCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	44588515	174575	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	372	6	2	7	2.6	CCCn1c(=O)c2[nH]c(-c3ccc([N+](=O)[O-])cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457014	174575	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	372	6	2	7	2.6	CCCn1c(=O)c2[nH]c(-c3ccc([N+](=O)[O-])cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	176407	4069	76	None	-34	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00237
	405	4069	76	None	-34	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00237
	CHEMBL113142	4069	76	None	-34	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00237
	DB08770	4069	76	None	-34	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00237
	176407	4069	76	None	-34	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm4011669
	405	4069	76	None	-34	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm4011669
	CHEMBL113142	4069	76	None	-34	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm4011669
	DB08770	4069	76	None	-34	6	Human	7.3	pKi	=	7.3	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/jm4011669
	CHEMBL5084351	213128	3	None	-33	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(N)nc1-c1cccc(O)c1	10.1021/acs.jmedchem.1c01636
	56844240	1086	0	None	-11	3	Human	7.3	pKi	=	7.3	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	277	2	1	5	2.8	Nc1nnc(c(n1)c1ccccc1)c1cc(C)nc(c1)C	10.1021/jm201376w
	9236	1086	0	None	-11	3	Human	7.3	pKi	=	7.3	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	277	2	1	5	2.8	Nc1nnc(c(n1)c1ccccc1)c1cc(C)nc(c1)C	10.1021/jm201376w
	CHEMBL2024115	1086	0	None	-11	3	Human	7.3	pKi	=	7.3	Binding	Inhibition of adenosine A2B receptorInhibition of adenosine A2B receptor	ChEMBL	277	2	1	5	2.8	Nc1nnc(c(n1)c1ccccc1)c1cc(C)nc(c1)C	10.1021/jm201376w
	137636304	155648	0	None	-691	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	419	4	2	7	3.4	COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(C)(O)CC3)nc12	10.1021/acs.jmedchem.6b01584
	CHEMBL4064207	155648	0	None	-691	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	419	4	2	7	3.4	COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(C)(O)CC3)nc12	10.1021/acs.jmedchem.6b01584
	132941757	158341	0	None	-870	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	460	7	1	7	4.4	CCN(CC)C1CCC(C)(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)CC1	10.1021/acs.jmedchem.6b01584
	CHEMBL4095355	158341	0	None	-870	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	460	7	1	7	4.4	CCN(CC)C1CCC(C)(C(=O)Nc2nc3c(OC)ccc(N4CCOCC4)c3s2)CC1	10.1021/acs.jmedchem.6b01584
	145973260	164035	0	None	-11481	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-MRS-1754 from human A2B receptor expressed in HEK293 cell membranes after 90 mins radioligand binding assayDisplacement of [3H]-MRS-1754 from human A2B receptor expressed in HEK293 cell membranes after 90 mins radioligand binding assay	ChEMBL	568	9	1	14	1.5	COCCOc1ccc(N2CCN(CCn3c(=O)n(C)c4c3nc(N)n3nc(-c5nccs5)nc43)CC2)cc1F	10.1021/acsmedchemlett.7b00175
	CHEMBL4215754	164035	0	None	-11481	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-MRS-1754 from human A2B receptor expressed in HEK293 cell membranes after 90 mins radioligand binding assayDisplacement of [3H]-MRS-1754 from human A2B receptor expressed in HEK293 cell membranes after 90 mins radioligand binding assay	ChEMBL	568	9	1	14	1.5	COCCOc1ccc(N2CCN(CCn3c(=O)n(C)c4c3nc(N)n3nc(-c5nccs5)nc43)CC2)cc1F	10.1021/acsmedchemlett.7b00175
	11618368	3774	68	None	-501	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/acs.jmedchem.6b01584
	5611	3774	68	None	-501	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/acs.jmedchem.6b01584
	CHEMBL2105747	3774	68	None	-501	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/acs.jmedchem.6b01584
	DB12203	3774	68	None	-501	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/acs.jmedchem.6b01584
	137634085	155736	0	None	-1258	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	463	6	1	7	4.2	COc1ccc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3ccc(F)c(F)c3)nc12	10.1021/acs.jmedchem.6b01584
	CHEMBL4065326	155736	0	None	-1258	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 mins	ChEMBL	463	6	1	7	4.2	COc1ccc(N2CCOCC2)c2sc(NC(=O)C(C)(C)Oc3ccc(F)c(F)c3)nc12	10.1021/acs.jmedchem.6b01584
	44574223	178124	0	None	6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	466	8	2	7	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL468306	178124	0	None	6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	466	8	2	7	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	44452435	96151	0	None	-39	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	383	5	1	6	4.1	O=C(CCc1ccccc1)Nc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	CHEMBL263372	96151	0	None	-39	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	383	5	1	6	4.1	O=C(CCc1ccccc1)Nc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	10346511	102560	3	None	-2754	8	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	517	5	4	9	1.3	OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm9905965
	CHEMBL307199	102560	3	None	-2754	8	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	ChEMBL	517	5	4	9	1.3	OC[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc32)[C@H](O)[C@@H]1O	10.1021/jm9905965
	11995448	140915	0	None	-22	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	473	9	2	8	2.0	CCCn1c(=O)c2nc([C@]34CC[C@](C(=O)NCCC(=O)OC)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	CHEMBL384257	140915	0	None	-22	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	473	9	2	8	2.0	CCCn1c(=O)c2nc([C@]34CC[C@](C(=O)NCCC(=O)OC)(CC3)CC4)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	24827556	159221	0	None	2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	381	5	1	8	0.8	CCCn1c(=O)c2[nH]c(-c3cnn(-c4ccc[n+]([O-])c4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	CHEMBL410529	159221	0	None	2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	381	5	1	8	0.8	CCCn1c(=O)c2[nH]c(-c3cnn(-c4ccc[n+]([O-])c4)c3)nc2n(CC)c1=O	10.1021/jm7014815
	156015785	177033	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cnco1	10.1021/acs.jmedchem.0c00564
	CHEMBL4640980	177033	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cnco1	10.1021/acs.jmedchem.0c00564
	135493292	99801	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	512	11	2	11	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)c(OC)c4)no3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL289002	99801	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	512	11	2	11	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)c(OC)c4)no3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135485985	98114	34	None	-2	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 44-58Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 44-58	ChEMBL	241	1	2	7	0.8	Nc1nc2n[nH]cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL276738	98114	34	None	-2	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 44-58Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 44-58	ChEMBL	241	1	2	7	0.8	Nc1nc2n[nH]cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	137650430	156645	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	290	3	2	5	1.7	CCOC(=O)C1=C(C)N/C(=N\C#N)NC1c1cccs1	10.1021/acs.jmedchem.7b00138
	CHEMBL4075899	156645	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	290	3	2	5	1.7	CCOC(=O)C1=C(C)N/C(=N\C#N)NC1c1cccs1	10.1021/acs.jmedchem.7b00138
	1329	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.bmc.2010.09.043
	386	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.bmc.2010.09.043
	CHEMBL183	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.bmc.2010.09.043
	DB12946	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1016/j.bmc.2010.09.043
	1329	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241,385 binding to adenosine A2b receptorInhibition of [3H]ZM-241,385 binding to adenosine A2b receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm049513x
	386	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241,385 binding to adenosine A2b receptorInhibition of [3H]ZM-241,385 binding to adenosine A2b receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm049513x
	CHEMBL183	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241,385 binding to adenosine A2b receptorInhibition of [3H]ZM-241,385 binding to adenosine A2b receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm049513x
	DB12946	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241,385 binding to adenosine A2b receptorInhibition of [3H]ZM-241,385 binding to adenosine A2b receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm049513x
	1329	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm011049y
	386	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm011049y
	CHEMBL183	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm011049y
	DB12946	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm011049y
	137660466	158728	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	288	3	1	2	4.4	CC(=O)Nc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/acs.jmedchem.7b00860
	CHEMBL4099480	158728	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	288	3	1	2	4.4	CC(=O)Nc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/acs.jmedchem.7b00860
	11495410	72333	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	418	6	2	6	1.9	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL199688	72333	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	418	6	2	6	1.9	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccccc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	11590453	72364	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	448	7	2	7	1.9	COc1cccc(CNC(=O)COc2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)c1	10.1021/jm0506221
	CHEMBL199826	72364	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	448	7	2	7	1.9	COc1cccc(CNC(=O)COc2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)c1	10.1021/jm0506221
	44451480	95349	0	None	45	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	503	6	1	8	2.0	COc1ccccc1N1CCN(C(=O)COc2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)CC1	10.1016/j.bmc.2008.01.002
	CHEMBL258778	95349	0	None	45	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	503	6	1	8	2.0	COc1ccccc1N1CCN(C(=O)COc2ccc(-c3cc4c([nH]3)c(=O)n(C)c(=O)n4C)cc2)CC1	10.1016/j.bmc.2008.01.002
	44451201	95672	0	None	30	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	619	11	1	7	5.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260434	95672	0	None	30	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	619	11	1	7	5.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(c5ccccc5)c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	168273637	189712	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	410	7	1	8	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(OS(=O)(=O)F)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5176227	189712	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	410	7	1	8	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(OS(=O)(=O)F)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5079596	212843	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2ccccc2)nc(Nc2ccccc2)nc1-c1ccc(F)cc1	10.1021/acs.jmedchem.1c01636
	14978313	102169	0	None	4	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	204	1	1	5	-0.9	C#CCn1c(=O)c2[nH]cnc2n(C)c1=O	10.1021/jm0104318
	CHEMBL304455	102169	0	None	4	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	204	1	1	5	-0.9	C#CCn1c(=O)c2[nH]cnc2n(C)c1=O	10.1021/jm0104318
	165412580	191394	3	None	-50	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysis	ChEMBL	450	11	3	9	3.6	Nc1nc(-c2ccco2)c2cnn(Cc3cccc(OCCCCCCC(=O)NO)c3)c2n1	10.1016/j.ejmech.2022.114326
	CHEMBL5201523	191394	3	None	-50	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysis	ChEMBL	450	11	3	9	3.6	Nc1nc(-c2ccco2)c2cnn(Cc3cccc(OCCCCCCC(=O)NO)c3)c2n1	10.1016/j.ejmech.2022.114326
	12351799	188721	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	2	5	1.2	Cc1ccc(-c2[nH]c3c(=O)n(C)c(=O)n(C)c3c2O)cc1	10.1016/j.bmc.2008.09.067
	CHEMBL512388	188721	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	2	5	1.2	Cc1ccc(-c2[nH]c3c(=O)n(C)c(=O)n(C)c3c2O)cc1	10.1016/j.bmc.2008.09.067
	11313850	111074	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	341	5	1	7	2.0	CCCn1c(=O)c2c(nc(-c3ccc(N)cc3)n2C)n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32814	111074	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	341	5	1	7	2.0	CCCn1c(=O)c2c(nc(-c3ccc(N)cc3)n2C)n(CCC)c1=O	10.1021/jm0309654
	156020536	177565	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	336	3	2	5	3.6	CC1=C(C(=O)OC(C)C)C(c2cc[nH]c2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4648862	177565	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	336	3	2	5	3.6	CC1=C(C(=O)OC(C)C)C(c2cc[nH]c2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	21958721	63787	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(Cl)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL180832	63787	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(Cl)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	11494318	71897	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	215	1	1	7	0.1	Cn1c(-n2nccn2)nc2c(N)nccc21	10.1021/jm058018d
	CHEMBL198200	71897	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPXBinding affinity towards human Adenosine A2b receptor expressed in HEK293 cells using 5 nM [3H]DPCPX	ChEMBL	215	1	1	7	0.1	Cn1c(-n2nccn2)nc2c(N)nccc21	10.1021/jm058018d
	2099	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	10.1021/jm0104318
	4740	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	10.1021/jm0104318
	7095	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	10.1021/jm0104318
	CHEMBL628	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	10.1021/jm0104318
	DB00806	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	10.1021/jm0104318
	10928649	57823	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	461	7	2	10	4.1	CCCCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL167915	57823	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX binding at human Adenosine A2B receptor expressed in HEK293 cells	ChEMBL	461	7	2	10	4.1	CCCCn1cc2c(nc(NC(=O)Nc3ccc([N+](=O)[O-])cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	155560449	174501	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4568571	174501	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccoc2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	11613517	72368	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	536	10	2	7	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199834	72368	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	536	10	2	7	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	10421804	99272	0	None	-5	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	241	1	2	3	1.2	Cn1c(=O)[nH]c2cc(-c3ccccc3)[nH]c2c1=O	10.1021/jm011049y
	CHEMBL284991	99272	0	None	-5	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	241	1	2	3	1.2	Cn1c(=O)[nH]c2cc(-c3ccccc3)[nH]c2c1=O	10.1021/jm011049y
	155533281	171256	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	304	3	2	4	2.0	CCOC(=O)C1=C(C(F)(F)F)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.9b01340
	CHEMBL4468661	171256	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	304	3	2	4	2.0	CCOC(=O)C1=C(C(F)(F)F)NC(=O)NC1c1ccoc1	10.1021/acs.jmedchem.9b01340
	168276821	189504	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	410	7	1	8	2.0	CCCn1c(=O)c2[nH]c(-c3cccc(OS(=O)(=O)F)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5172969	189504	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	410	7	1	8	2.0	CCCn1c(=O)c2[nH]c(-c3cccc(OS(=O)(=O)F)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	52949755	19027	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	468	6	2	5	3.2	Cc1c(S(C)(=O)=O)c(=O)[nH]c2ccc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)cc12	10.1016/j.bmcl.2010.10.030
	CHEMBL1290103	19027	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	468	6	2	5	3.2	Cc1c(S(C)(=O)=O)c(=O)[nH]c2ccc(OCC(=O)NCc3ccc(Cl)c(Cl)c3)cc12	10.1016/j.bmcl.2010.10.030
	21958676	63563	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(C)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL180559	63563	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccc(C)cc5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	135529372	109609	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	482	10	2	10	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)cc4)no3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32359	109609	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	482	10	2	10	2.4	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(OC)cc4)no3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10637742	58629	0	None	-33	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 40-69Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 40-69	ChEMBL	297	4	1	8	2.1	CCCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL16894	58629	0	None	-33	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 40-69Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 40-69	ChEMBL	297	4	1	8	2.1	CCCCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	10939224	57217	0	None	-173	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 40-69Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 40-69	ChEMBL	446	5	2	10	3.5	CCCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL166301	57217	0	None	-173	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 40-69Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 40-69	ChEMBL	446	5	2	10	3.5	CCCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	9902563	188194	0	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	341	3	1	8	2.4	Cc1csc(-c2nc(N)nc3c2nnn3Cc2ccccc2F)n1	10.1021/jm800961g
	CHEMBL505787	188194	0	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	341	3	1	8	2.4	Cc1csc(-c2nc(N)nc3c2nnn3Cc2ccccc2F)n1	10.1021/jm800961g
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.0c01431
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.0c01431
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.0c01431
	11416002	98023	2	None	40	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	322	2	3	6	-0.1	Cn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)O)cc3)nc2c1=O	10.1021/jm0310030
	CHEMBL275987	98023	2	None	40	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	322	2	3	6	-0.1	Cn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)O)cc3)nc2c1=O	10.1021/jm0310030
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm900413e
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm060277v
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm060277v
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm060277v
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human recombinant Adenosine A2B receptorDisplacement of [3H]ZM241385 from human recombinant Adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.5b01586
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human recombinant Adenosine A2B receptorDisplacement of [3H]ZM241385 from human recombinant Adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.5b01586
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human recombinant Adenosine A2B receptorDisplacement of [3H]ZM241385 from human recombinant Adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.5b01586
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human recombinant adenosine A2B receptorDisplacement of [3H]ZM241385 from human recombinant adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.7b00138
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human recombinant adenosine A2B receptorDisplacement of [3H]ZM241385 from human recombinant adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.7b00138
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human recombinant adenosine A2B receptorDisplacement of [3H]ZM241385 from human recombinant adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.7b00138
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 30 mins by scintillation counting methodDisplacement of [3H]ZM241385 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 30 mins by scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 30 mins by scintillation counting methodDisplacement of [3H]ZM241385 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 30 mins by scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 30 mins by scintillation counting methodDisplacement of [3H]ZM241385 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 30 mins by scintillation counting method	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/acs.jmedchem.9b00071
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm011049y
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm011049y
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	10.1021/jm011049y
	44451171	95589	0	None	28	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	487	6	1	7	2.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259913	95589	0	None	28	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	487	6	1	7	2.0	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	11640619	137844	0	None	-9	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	433	9	2	6	2.3	CCCN(CCC)S(=O)(=O)c1ccc(-c2nc3c(=O)n(CCC)c(=O)[nH]c3[nH]2)cc1	10.1021/jm060277v
	CHEMBL377246	137844	0	None	-9	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	433	9	2	6	2.3	CCCN(CCC)S(=O)(=O)c1ccc(-c2nc3c(=O)n(CCC)c(=O)[nH]c3[nH]2)cc1	10.1021/jm060277v
	1882	90207	56	None	-3	5	Rat	5.3	pKi	=	5.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	242	2	0	6	-0.3	Cn1c(=O)c2c(ncn2CCCl)n(C)c1=O	10.1021/jm0104318
	CHEMBL23903	90207	56	None	-3	5	Rat	5.3	pKi	=	5.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	242	2	0	6	-0.3	Cn1c(=O)c2c(ncn2CCCl)n(C)c1=O	10.1021/jm0104318
	11798195	121165	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 45-64Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 45-64	ChEMBL	460	7	2	9	4.4	COc1ccc(NC(=O)Nc2nc3nn(CCC(C)C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	CHEMBL358735	121165	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 45-64Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 45-64	ChEMBL	460	7	2	9	4.4	COc1ccc(NC(=O)Nc2nc3nn(CCC(C)C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	44588395	189182	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	327	5	2	5	2.7	CCCn1c(=O)c2[nH]c(-c3ccccc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL516154	189182	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	327	5	2	5	2.7	CCCn1c(=O)c2[nH]c(-c3ccccc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	21958758	72524	0	None	48	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	474	8	1	10	3.0	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(C)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200349	72524	0	None	48	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	474	8	1	10	3.0	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(C)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11517635	74584	0	None	18	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	6	1	6	2.3	CN(Cc1ccccc1)C(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1021/jm0506221
	CHEMBL203196	74584	0	None	18	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	6	1	6	2.3	CN(Cc1ccccc1)C(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1	10.1021/jm0506221
	71681055	89762	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	330	5	1	5	3.7	O=C(CCCc1ccccc1)Nc1nc2ccsc2c(=O)s1	10.1021/jm400336x
	CHEMBL2382424	89762	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	330	5	1	5	3.7	O=C(CCCc1ccccc1)Nc1nc2ccsc2c(=O)s1	10.1021/jm400336x
	46227980	200196	0	None	2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	368	6	1	7	2.4	C=CCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL607371	200196	0	None	2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	368	6	1	7	2.4	C=CCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	135522391	116580	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	552	9	1	10	2.0	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(c5ccc(F)cc5)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33930	116580	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	552	9	1	10	2.0	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(c5ccc(F)cc5)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135915277	156797	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	451	7	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC#Cc4cccc(F)c4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4077765	156797	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	451	7	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC#Cc4cccc(F)c4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	44406639	72232	0	None	23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(C(F)(F)F)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL199309	72232	0	None	23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccc(C(F)(F)F)cc5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	135805568	138585	2	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	288	3	1	7	2.1	CC1=C(C(=O)OC(C)C)C(c2ccco2)n2ncnc2N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3786944	138585	2	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	288	3	1	7	2.1	CC1=C(C(=O)OC(C)C)C(c2ccco2)n2ncnc2N1	10.1021/acs.jmedchem.5b01586
	11153	1969	40	None	-35	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	315	2	1	5	3.3	Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl	10.1021/acs.jmedchem.2c00101
	86676119	1969	40	None	-35	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	315	2	1	5	3.3	Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl	10.1021/acs.jmedchem.2c00101
	CHEMBL4594442	1969	40	None	-35	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	315	2	1	5	3.3	Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl	10.1021/acs.jmedchem.2c00101
	DB16192	1969	40	None	-35	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	315	2	1	5	3.3	Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl	10.1021/acs.jmedchem.2c00101
	10219753	201969	2	None	5	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	190	1	2	4	-1.0	C#CCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	CHEMBL67415	201969	2	None	5	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	190	1	2	4	-1.0	C#CCn1c(=O)[nH]c2[nH]cnc2c1=O	10.1021/jm0104318
	13525048	97714	0	None	2	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	300	2	2	6	0.3	Cn1c(=O)c2nc(-c3cccc(C(=O)O)c3)[nH]c2n(C)c1=O	10.1021/jm0104318
	CHEMBL273953	97714	0	None	2	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	300	2	2	6	0.3	Cn1c(=O)c2nc(-c3cccc(C(=O)O)c3)[nH]c2n(C)c1=O	10.1021/jm0104318
	10869347	201940	0	None	-8	4	Rat	5.3	pKi	=	5.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	270	3	1	5	0.7	Cn1c(=O)n(CCc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	CHEMBL67228	201940	0	None	-8	4	Rat	5.3	pKi	=	5.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	ChEMBL	270	3	1	5	0.7	Cn1c(=O)n(CCc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	44410403	75641	0	None	-2884	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	458	5	5	10	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC4(O)CCCCC4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL205531	75641	0	None	-2884	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	458	5	5	10	0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC4(O)CCCCC4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	44390583	63943	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccccc5OC)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL181005	63943	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	516	10	1	10	4.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5ccccc5OC)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	135529391	478	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	438	478	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL285900	478	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	135529391	478	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	438	478	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	CHEMBL285900	478	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	10.1021/jm0309654
	16071780	57701	0	None	15	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	4	1	6	2.5	O=C(Nc1cnc(-c2ccncc2)c(-c2ncco2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672624	57701	0	None	15	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	307	4	1	6	2.5	O=C(Nc1cnc(-c2ccncc2)c(-c2ncco2)n1)C1CC1	10.1021/ml100249e
	135874431	95796	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	463	8	2	8	2.8	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(C)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL261028	95796	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	463	8	2	8	2.8	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(C)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	1329	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm051268+
	386	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm051268+
	CHEMBL183	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm051268+
	DB12946	1439	78	None	-1288	14	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm051268+
	11519405	72394	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	532	11	2	8	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)OCC)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199898	72394	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	532	11	2	8	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)OCC)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	18079460	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091704	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	18079460	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/ml400185v
	CHEMBL3091704	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/ml400185v
	18079460	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3091704	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.5b01586
	18079460	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL3091704	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.7b00138
	18079460	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL3091704	103358	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	280	3	2	4	2.3	CC1=C(C(=O)OC(C)C)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	162675859	182730	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	290	4	2	4	2.3	CC1=C(C(=O)OCC2CCC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4797364	182730	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	290	4	2	4	2.3	CC1=C(C(=O)OCC2CCC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	168276821	189504	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	410	7	1	8	2.0	CCCn1c(=O)c2[nH]c(-c3cccc(OS(=O)(=O)F)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5172969	189504	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	410	7	1	8	2.0	CCCn1c(=O)c2[nH]c(-c3cccc(OS(=O)(=O)F)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	76011	201953	7	None	2	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	256	3	0	6	0.1	Cn1c(=O)c2c(ncn2CCCCl)n(C)c1=O	10.1021/jm0104318
	CHEMBL67323	201953	7	None	2	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	256	3	0	6	0.1	Cn1c(=O)c2c(ncn2CCCCl)n(C)c1=O	10.1021/jm0104318
	135443324	110939	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	393	4	2	8	0.5	Cn1nc(NC(=O)Cc2ccccc2)cc1-c1nc2c(=O)n(C)c(=O)n(C)c2[nH]1	10.1021/jm0309654
	CHEMBL32750	110939	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	393	4	2	8	0.5	Cn1nc(NC(=O)Cc2ccccc2)cc1-c1nc2c(=O)n(C)c(=O)n(C)c2[nH]1	10.1021/jm0309654
	9910926	29103	0	None	-11	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 50-63Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 50-63	ChEMBL	436	5	2	8	4.4	CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL138332	29103	0	None	-11	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 50-63Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 50-63	ChEMBL	436	5	2	8	4.4	CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	9910926	29103	0	None	-11	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 50-63Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 50-63	ChEMBL	436	5	2	8	4.4	CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL138332	29103	0	None	-11	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 50-63Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 50-63	ChEMBL	436	5	2	8	4.4	CCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	9869262	104369	0	None	-9	3	Rat	7.2	pKi	=	7.2	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	CHEMBL310997	104369	0	None	-9	3	Rat	7.2	pKi	=	7.2	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	44451169	95588	0	None	25	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	503	6	1	8	2.0	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)N1CCN(c2ccccc2)CC1	10.1016/j.bmc.2008.01.002
	CHEMBL259912	95588	0	None	25	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	503	6	1	8	2.0	COc1cc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)ccc1OCC(=O)N1CCN(c2ccccc2)CC1	10.1016/j.bmc.2008.01.002
	377	2707	47	None	-1479	15	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	425	2707	47	None	-1479	15	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	448222	2707	47	None	-1479	15	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	CHEMBL464859	2707	47	None	-1479	15	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm900413e
	155531946	171169	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	320	3	2	4	2.5	CCOC(=O)C1=C(C(F)(F)F)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.9b01340
	CHEMBL4467283	171169	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	320	3	2	4	2.5	CCOC(=O)C1=C(C(F)(F)F)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.9b01340
	162643792	181164	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	290	3	2	4	2.4	CC1=C(C(=O)OC2CCCC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4777520	181164	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	290	3	2	4	2.4	CC1=C(C(=O)OC2CCCC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	145989810	166629	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	586	14	1	9	4.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCc3ccccc3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	CHEMBL4291422	166629	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	586	14	1	9	4.1	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCc3ccccc3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	137637685	155244	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	408	7	1	6	4.4	COc1cccc(-c2cc(NC(C)=O)nc(-c3cccc(OC)c3OC)c2)c1OC	10.1021/acs.jmedchem.7b00860
	CHEMBL4059638	155244	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	408	7	1	6	4.4	COc1cccc(-c2cc(NC(C)=O)nc(-c3cccc(OC)c3OC)c2)c1OC	10.1021/acs.jmedchem.7b00860
	44281738	110143	0	None	20	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	476	8	3	7	4.0	CCCn1c(=O)c2nc(-c3ccc(NC(=O)Nc4cccc(OC)c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32581	110143	0	None	20	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	476	8	3	7	4.0	CCCn1c(=O)c2nc(-c3ccc(NC(=O)Nc4cccc(OC)c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135493238	116159	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	331	5	2	8	0.7	CCCn1c(=O)c2nc(-c3cc(N)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL33709	116159	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	331	5	2	8	0.7	CCCn1c(=O)c2nc(-c3cc(N)n(C)n3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	9868763	34320	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 52-65Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 52-65	ChEMBL	458	6	2	9	4.4	COc1ccc(NC(=O)Nc2nc3nn(CC=C(C)C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	CHEMBL142926	34320	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 52-65Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 52-65	ChEMBL	458	6	2	9	4.4	COc1ccc(NC(=O)Nc2nc3nn(CC=C(C)C)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	11503200	77726	0	None	9	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	444	7	1	7	3.4	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(Cl)c4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210213	77726	0	None	9	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	444	7	1	7	3.4	CCCn1c(=O)c2nc(-c3cnn(Cc4cccc(Cl)c4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL5084903	213155	0	None	-12	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL		None	None	None		Nc1nc(-c2ccccc2)c2c(n1)-c1cc(OCCCN3CCCCC3)ccc1C2	10.1021/acs.jmedchem.0c00914
	44451129	95686	0	None	12	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	474	5	1	8	1.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccn5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL260495	95686	0	None	12	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	474	5	1	8	1.4	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccn5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL5076643	212675	0	None	-2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] DPCPX from human recombinant A2B adenosine receptor expressed in HEK293 cells incubated for 30 mins by radioligand binding competition assayDisplacement of [3H] DPCPX from human recombinant A2B adenosine receptor expressed in HEK293 cells incubated for 30 mins by radioligand binding competition assay	ChEMBL		None	None	None		Cn1cc(-c2cnc(N)nc2-c2ccco2)ccc1=O	10.1021/acsmedchemlett.1c00599
	135428645	172124	0	None	-204	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	371	4	2	4	2.9	CCCN1C(=O)N2C[C@@H](CC)N=C2c2[nH]c(C34CCC(O)(CC3)CC4)nc21	10.1021/jm060539t
	CHEMBL450341	172124	0	None	-204	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	371	4	2	4	2.9	CCCN1C(=O)N2C[C@@H](CC)N=C2c2[nH]c(C34CCC(O)(CC3)CC4)nc21	10.1021/jm060539t
	25027417	64134	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	311	3	2	5	2.8	COc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1O	10.1016/j.ejmech.2012.05.033
	CHEMBL1814065	64134	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	311	3	2	5	2.8	COc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1O	10.1016/j.ejmech.2012.05.033
	21958720	63143	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5Cl)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL179935	63143	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	520	9	1	9	4.7	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5Cl)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	613506	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL1606497	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	613506	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.9b01340
	CHEMBL1606497	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.9b01340
	613506	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.5b01586
	CHEMBL1606497	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.5b01586
	613506	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.7b00138
	CHEMBL1606497	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.7b00138
	613506	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/ml400185v
	CHEMBL1606497	53785	16	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	250	3	2	4	1.5	CCOC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/ml400185v
	11380878	196067	0	None	-630	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	295	4	2	6	1.6	Nc1nc(C(=O)NCc2cccnc2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL571672	196067	0	None	-630	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	295	4	2	6	1.6	Nc1nc(C(=O)NCc2cccnc2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	155513258	169147	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	304	3	2	4	2.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4438396	169147	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	304	3	2	4	2.0	CC1=C(C(=O)OCC(F)(F)F)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	46233380	198987	0	None	-3	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	374	7	1	6	1.7	CCCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(CC[S+]([O-])CC)c1=O	10.1016/j.bmc.2010.01.028
	CHEMBL599817	198987	0	None	-3	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by microplate beta scintillation counter	ChEMBL	374	7	1	6	1.7	CCCn1c(=O)c2[nH]c(-c3ccccc3)nc2n(CC[S+]([O-])CC)c1=O	10.1016/j.bmc.2010.01.028
	44406930	72671	0	None	-2754	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	572	9	1	7	4.2	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)c4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201022	72671	0	None	-2754	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	572	9	1	7	4.2	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)c4ccc(I)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	44588396	174856	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	341	5	1	6	3.0	CCCn1c(=O)c2c(cc(-c3ccc(C)cc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457659	174856	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	341	5	1	6	3.0	CCCn1c(=O)c2c(cc(-c3ccc(C)cc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	135493286	109263	0	None	40	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	493	8	3	9	2.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)Nc4ccc(N(C)C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32311	109263	0	None	40	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	493	8	3	9	2.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)Nc4ccc(N(C)C)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	21874675	178115	0	None	-53	4	Human	7.2	pKi	=	7.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	331	3	2	7	2.6	Nc1nc(-c2ccco2)c2nnn(Cc3ccc4[nH]ccc4c3)c2n1	10.1021/jm800961g
	CHEMBL468256	178115	0	None	-53	4	Human	7.2	pKi	=	7.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	331	3	2	7	2.6	Nc1nc(-c2ccco2)c2nnn(Cc3ccc4[nH]ccc4c3)c2n1	10.1021/jm800961g
	137658586	158750	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	288	3	2	5	1.6	CC1=C(C(=O)OC(C)C)C(c2ccoc2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL4099777	158750	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	288	3	2	5	1.6	CC1=C(C(=O)OC(C)C)C(c2ccoc2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	44308481	202309	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	374	6	3	8	1.8	CCCn1c(=O)c2nc(-c3cc(O)c(OC)c(O)c3)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL69701	202309	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	374	6	3	8	1.8	CCCn1c(=O)c2nc(-c3cc(O)c(OC)c(O)c3)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	10927361	90423	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	395	7	0	7	2.6	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2)n(CCC)c1=O	10.1016/j.bmc.2007.07.051
	CHEMBL239233	90423	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	395	7	0	7	2.6	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2)n(CCC)c1=O	10.1016/j.bmc.2007.07.051
	21874602	176198	0	None	-54	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	377	5	2	8	2.3	CC(C)NC(=O)c1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	CHEMBL460596	176198	0	None	-54	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	377	5	2	8	2.3	CC(C)NC(=O)c1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	10158974	154956	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	418	5	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1021/acs.jmedchem.0c01431
	CHEMBL404168	154956	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human A2B receptorAntagonist activity at human A2B receptor	ChEMBL	418	5	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1021/acs.jmedchem.0c01431
	66892382	158594	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	559	9	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(OC(F)(F)F)cc5)C4=O)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4098127	158594	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	559	9	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5ccc(OC(F)(F)F)cc5)C4=O)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	57429661	159067	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5cccc(C(F)(F)F)c5)C4=O)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4103446	159067	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CCN(c5cccc(C(F)(F)F)c5)C4=O)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	11774068	94115	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	404	4	2	6	2.4	CCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251876	94115	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	404	4	2	6	2.4	CCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	21958524	94144	0	None	29	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	362	5	2	6	1.7	O=c1[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	CHEMBL252069	94144	0	None	29	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	362	5	2	6	1.7	O=c1[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c(=O)n1CC1CC1	10.1016/j.bmcl.2008.01.008
	11953248	5432	0	None	52	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	279	2	2	5	2.0	O=c1[nH]c2cc(-c3ccncn3)c(-c3ccco3)nc2[nH]1	10.1016/j.bmcl.2010.01.077
	CHEMBL1076563	5432	0	None	52	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	279	2	2	5	2.0	O=c1[nH]c2cc(-c3ccncn3)c(-c3ccco3)nc2[nH]1	10.1016/j.bmcl.2010.01.077
	16072019	57689	0	None	75	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	280	3	1	5	2.8	CC(=O)Nc1cnc(-c2ccncc2)c(-c2ccco2)n1	10.1021/ml100249e
	CHEMBL1672612	57689	0	None	75	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	280	3	1	5	2.8	CC(=O)Nc1cnc(-c2ccncc2)c(-c2ccco2)n1	10.1021/ml100249e
	53322692	57709	0	None	67	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	325	4	1	6	2.7	O=C(Nc1cnc(-c2ccncc2F)c(-c2ncco2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672632	57709	0	None	67	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	325	4	1	6	2.7	O=C(Nc1cnc(-c2ccncc2F)c(-c2ncco2)n1)C1CC1	10.1021/ml100249e
	21958619	95476	0	None	38	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	418	4	1	7	2.4	CCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL259342	95476	0	None	38	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	418	4	1	7	2.4	CCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	11508923	95685	0	None	38	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	368	4	1	7	1.5	CCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL260490	95685	0	None	38	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	368	4	1	7	1.5	CCn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	49797906	10629	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	467	7	1	7	4.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(F)c4)c3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1171165	10629	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	467	7	1	7	4.3	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3cnn(Cc4cccc(F)c4)c3)sc12	10.1016/j.bmcl.2010.05.056
	21874647	176330	0	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	324	3	1	7	2.6	Cc1ccc(-c2nc(N)nc3c2nnn3Cc2ccccc2F)o1	10.1021/jm800961g
	CHEMBL461857	176330	0	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	324	3	1	7	2.6	Cc1ccc(-c2nc(N)nc3c2nnn3Cc2ccccc2F)o1	10.1021/jm800961g
	135418454	16335	0	None	-7	4	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells at 10000 nMInhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells at 10000 nM	ChEMBL	360	4	1	5	4.0	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(C(F)(F)F)cc3)nn12	10.1021/jm010570p
	CHEMBL123705	16335	0	None	-7	4	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells at 10000 nMInhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells at 10000 nM	ChEMBL	360	4	1	5	4.0	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(C(F)(F)F)cc3)nn12	10.1021/jm010570p
	11555968	73025	0	None	5	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	566	10	2	6	5.5	CCCn1c(=O)c2[nH]c(-c3ccc(OC(CC)C(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201493	73025	0	None	5	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	566	10	2	6	5.5	CCCn1c(=O)c2[nH]c(-c3ccc(OC(CC)C(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44451074	158251	0	None	79	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	535	7	1	7	3.5	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL409443	158251	0	None	79	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	535	7	1	7	3.5	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	155518147	169677	0	None	27	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	554	9	3	9	1.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OCCO)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4445941	169677	0	None	27	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	554	9	3	9	1.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OCCO)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	11730776	138847	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	498	8	2	8	1.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(=O)OCC)CC4)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL37933	138847	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	498	8	2	8	1.6	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(=O)OCC)CC4)cc3)nc2c1=O	10.1021/jm011049y
	44450979	95432	0	None	66	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	530	8	1	7	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5OC)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL259151	95432	0	None	66	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	530	8	1	7	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5OC)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	44450983	158323	0	None	6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	543	10	1	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL409514	158323	0	None	6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	543	10	1	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	44450983	158323	0	None	6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	543	10	1	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL409514	158323	0	None	6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	543	10	1	7	3.7	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	44236505	159080	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	446	7	1	8	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4103585	159080	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	446	7	1	8	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(OC)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	7052992	182735	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)[C@@H](c2ccco2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4797393	182735	2	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.0	CC1=C(C(=O)OC(C)C)[C@@H](c2ccco2)NC(=S)N1	10.1021/acs.jmedchem.0c01431
	44451284	96004	0	None	56	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	5	1	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5Cl)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL262333	96004	0	None	56	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	507	5	1	7	2.6	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5Cl)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	44451272	159027	0	None	56	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	498	5	1	8	1.8	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C#N)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL410297	159027	0	None	56	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	498	5	1	8	1.8	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C#N)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	44224278	155817	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	430	6	1	7	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4066128	155817	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	430	6	1	7	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C)cc4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	66893874	158749	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4099762	158749	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	543	8	1	8	3.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44588516	188316	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	405	6	2	7	2.1	CCCn1c(=O)c2[nH]c(-c3ccc(S(C)(=O)=O)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL507754	188316	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	405	6	2	7	2.1	CCCn1c(=O)c2[nH]c(-c3ccc(S(C)(=O)=O)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	10863622	132877	0	None	4	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	468	7	2	7	1.0	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(C)=O)CC4)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL37050	132877	0	None	4	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	468	7	2	7	1.0	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(C(C)=O)CC4)cc3)nc2c1=O	10.1021/jm011049y
	44450933	95580	0	None	36	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	543	9	1	7	4.1	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259871	95580	0	None	36	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	543	9	1	7	4.1	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)C(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	44236659	159113	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	434	6	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4103997	159113	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	434	6	1	7	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(F)c4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	52945195	18970	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	525	10	3	6	4.7	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)N[C@@H](CO)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289676	18970	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	525	10	3	6	4.7	O=C(COc1ccc2[nH]c(=O)c(-c3nccs3)c(CCc3ccccc3)c2c1)N[C@@H](CO)c1ccccc1	10.1016/j.bmcl.2010.10.030
	11046203	99497	3	None	8	4	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	344	2	2	4	1.5	C#CCn1c(=O)[nH]c2[nH]c(-c3ccc(Br)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL286527	99497	3	None	8	4	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	344	2	2	4	1.5	C#CCn1c(=O)[nH]c2[nH]c(-c3ccc(Br)cc3)nc2c1=O	10.1021/jm011049y
	155531840	171066	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)O[C@H](C)C(F)(F)F)[C@@H](c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4465889	171066	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)O[C@H](C)C(F)(F)F)[C@@H](c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	11533996	72875	0	None	15	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	544	10	2	7	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC(F)(F)F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201239	72875	0	None	15	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	544	10	2	7	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OC(F)(F)F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11554182	140026	0	None	11	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	449	6	2	8	2.2	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL381214	140026	0	None	11	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	449	6	2	8	2.2	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44450932	95579	0	None	5	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	563	9	1	7	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5Cl)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259870	95579	0	None	5	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	563	9	1	7	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5Cl)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL5074665	212543	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		CNc1nc(-c2ccccc2)c(C#N)c(-c2cc(OC)cc(OC)c2)n1	10.1021/acs.jmedchem.1c01636
	135874422	158527	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	509	10	2	10	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(OC)c(OC)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL409736	158527	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	509	10	2	10	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(OC)c(OC)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	21916398	95428	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	5	1	7	2.1	CC(C)Cn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	CHEMBL259130	95428	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	5	1	7	2.1	CC(C)Cn1c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc2n(C)c1=O	10.1021/jm7014815
	443	742	7	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10.1021/jm011049y
	6439089	742	7	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10.1021/jm011049y
	CHEMBL16997	742	7	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10.1021/jm011049y
	11713673	72342	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	546	12	2	8	4.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC(=O)OCC)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL199722	72342	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	546	12	2	8	4.1	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CC(=O)OCC)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11634901	73150	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4cccc(F)c4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201679	73150	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	512	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4cccc(F)c4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	168271107	189466	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	394	6	1	7	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)F)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5172513	189466	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	394	6	1	7	2.0	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)F)cc3)nc2n(CCC)c1=O	10.1039/d2md00132b
	935972	97072	9	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	272	1	2	6	0.3	Cn1c(=O)c2nc(-c3ccc(O)cc3)[nH]c2n(C)c1=O	10.1021/jm0104318
	CHEMBL27047	97072	9	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	272	1	2	6	0.3	Cn1c(=O)c2nc(-c3ccc(O)cc3)[nH]c2n(C)c1=O	10.1021/jm0104318
	44574224	178007	0	None	3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	466	8	2	7	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4cccs4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL467270	178007	0	None	3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	466	8	2	7	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4cccs4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	135633267	138604	15	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	274	3	1	7	1.7	CCOC(=O)C1=C(C)Nc2ncnn2C1c1ccoc1	10.1021/acs.jmedchem.5b01586
	CHEMBL3787123	138604	15	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	274	3	1	7	1.7	CCOC(=O)C1=C(C)Nc2ncnn2C1c1ccoc1	10.1021/acs.jmedchem.5b01586
	2748280	19918	31	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	266	3	2	5	2.0	CCOC(=O)C1=C(C)N=C(S)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL1304358	19918	31	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	266	3	2	5	2.0	CCOC(=O)C1=C(C)N=C(S)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	2748280	19918	31	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	266	3	2	5	2.0	CCOC(=O)C1=C(C)N=C(S)NC1c1ccco1	10.1021/ml400185v
	CHEMBL1304358	19918	31	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	266	3	2	5	2.0	CCOC(=O)C1=C(C)N=C(S)NC1c1ccco1	10.1021/ml400185v
	11798368	121398	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 55-68Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 55-68	ChEMBL	464	6	2	8	5.1	CC(C)CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL359044	121398	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 55-68Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 55-68	ChEMBL	464	6	2	8	5.1	CC(C)CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	10982985	119484	0	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 49-77Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 49-77	ChEMBL	436	5	2	8	4.4	CCCn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL350042	119484	0	None	-2	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 49-77Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 49-77	ChEMBL	436	5	2	8	4.4	CCCn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	136042337	70804	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	520	10	1	12	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4noc(-c5cccc(OC)c5)n4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955913	70804	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	520	10	1	12	2.7	CCCn1c(=O)c2[nH]c(-c3cc(OCc4noc(-c5cccc(OC)c5)n4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	155522786	170175	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	318	3	2	4	2.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4452495	170175	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	318	3	2	4	2.4	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	46227959	200033	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	394	7	0	8	1.8	COCCn1c(=O)c2c(nc(Cc3ccccc3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL606535	200033	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	394	7	0	8	1.8	COCCn1c(=O)c2c(nc(Cc3ccccc3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	44417680	81714	0	None	-870	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	344	5	1	6	1.6	CCCn1c(=O)c2nc([C@H]3CC4C[C@@H]3[C@H]3O[C@@H]43)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	CHEMBL216750	81714	0	None	-870	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	344	5	1	6	1.6	CCCn1c(=O)c2nc([C@H]3CC4C[C@@H]3[C@H]3O[C@@H]43)[nH]c2n(CCC)c1=O	10.1021/jm0605381
	168272084	189678	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	369	6	1	7	3.1	CCCn1c(=O)c2[nH]c(-c3cccc(N=C=S)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5175698	189678	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	369	6	1	7	3.1	CCCn1c(=O)c2[nH]c(-c3cccc(N=C=S)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	1328	1337	30	None	-7	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	10.1021/jm0104318
	445	1337	30	None	-7	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	10.1021/jm0104318
	CHEMBL11348	1337	30	None	-7	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	10.1021/jm0104318
	57988794	156279	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	340	6	1	7	1.2	C#CCn1cc(-c2nc3c([nH]2)c(=O)n(CCC)c(=O)n3CCC)cn1	10.1016/j.ejmech.2017.04.014
	CHEMBL4071331	156279	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	340	6	1	7	1.2	C#CCn1cc(-c2nc3c([nH]2)c(=O)n(CCC)c(=O)n3CCC)cn1	10.1016/j.ejmech.2017.04.014
	24950690	178030	0	None	-9	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	275	2	1	4	3.8	Cc1cccc(-c2cc(-c3ccco3)nc(N)c2C#N)c1	10.1021/jm701594y
	CHEMBL467386	178030	0	None	-9	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	275	2	1	4	3.8	Cc1cccc(-c2cc(-c3ccco3)nc(N)c2C#N)c1	10.1021/jm701594y
	11352497	122439	0	None	-123	4	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	498	8	6	15	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(O)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	CHEMBL360837	122439	0	None	-123	4	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	498	8	6	15	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(N[C@H](CO)Cc5ccc(O)cc5)nc43)[C@H](O)[C@@H]2O)n1	10.1021/jm031143+
	152034	76177	8	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	278	5	1	5	1.6	CC(C)CCn1c(=O)c2nc[nH]c2n(CC(C)C)c1=O	10.1021/jm0104318
	CHEMBL20613	76177	8	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	278	5	1	5	1.6	CC(C)CCn1c(=O)c2nc[nH]c2n(CC(C)C)c1=O	10.1021/jm0104318
	2732424	21977	27	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	282	3	2	5	2.5	CCOC(=O)C1=C(C)N=C(S)NC1c1cccs1	10.1021/ml400185v
	CHEMBL1322729	21977	27	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	282	3	2	5	2.5	CCOC(=O)C1=C(C)N=C(S)NC1c1cccs1	10.1021/ml400185v
	16070216	57694	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	360	4	1	5	4.2	O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)c1ccc(F)cc1	10.1021/ml100249e
	CHEMBL1672617	57694	0	None	16	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	360	4	1	5	4.2	O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)c1ccc(F)cc1	10.1021/ml100249e
	44406328	133590	0	None	31	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	489	9	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccc(OC)cc5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL371649	133590	0	None	31	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	489	9	1	10	3.3	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccc(OC)cc5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	21874557	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm800961g
	5612	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm800961g
	CHEMBL447664	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm800961g
	DB06625	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm800961g
	21874557	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm4011669
	5612	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm4011669
	CHEMBL447664	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm4011669
	DB06625	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	10.1021/jm4011669
	11576751	72672	0	None	7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	488	10	2	7	3.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201024	72672	0	None	7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	488	10	2	7	3.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C=O)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	1329	1439	78	None	-1288	14	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm0104318
	386	1439	78	None	-1288	14	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm0104318
	CHEMBL183	1439	78	None	-1288	14	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm0104318
	DB12946	1439	78	None	-1288	14	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/jm0104318
	9901497	189578	0	None	-162	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	317	3	1	8	2.0	N#Cc1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	CHEMBL517417	189578	0	None	-162	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	317	3	1	8	2.0	N#Cc1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	70696536	75082	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	338	5	3	5	2.6	COc1cccc2cc(C(=O)NCCc3ccc(O)cc3)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	CHEMBL2042073	75082	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by beta scintillation counting	ChEMBL	338	5	3	5	2.6	COc1cccc2cc(C(=O)NCCc3ccc(O)cc3)c(=N)oc12	10.1016/j.ejmech.2012.05.009
	21874771	177979	0	None	-74	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	298	3	1	7	2.6	Nc1nc(-c2ccco2)c2nnn(CC3CCCCC3)c2n1	10.1021/jm800961g
	CHEMBL467035	177979	0	None	-74	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	298	3	1	7	2.6	Nc1nc(-c2ccco2)c2nnn(CC3CCCCC3)c2n1	10.1021/jm800961g
	162673363	182406	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.6	CC1=C(C(=O)SC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4793548	182406	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	280	3	2	4	2.6	CC1=C(C(=O)SC(C)C)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	25027418	64136	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	325	4	1	5	3.1	COc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1OC	10.1016/j.ejmech.2012.05.033
	CHEMBL1814067	64136	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	325	4	1	5	3.1	COc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1OC	10.1016/j.ejmech.2012.05.033
	67364057	73925	0	None	-15	3	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human adenosine A2b receptor expressed in HEK293T cells by radioligand competition binding assayAntagonist activity at human adenosine A2b receptor expressed in HEK293T cells by radioligand competition binding assay	ChEMBL	295	2	1	5	2.9	Cc1cc(-c2nnc(N)nc2-c2ccc(F)cc2)cc(C)n1	10.1021/acs.jmedchem.0c00237
	CHEMBL2024116	73925	0	None	-15	3	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human adenosine A2b receptor expressed in HEK293T cells by radioligand competition binding assayAntagonist activity at human adenosine A2b receptor expressed in HEK293T cells by radioligand competition binding assay	ChEMBL	295	2	1	5	2.9	Cc1cc(-c2nnc(N)nc2-c2ccc(F)cc2)cc(C)n1	10.1021/acs.jmedchem.0c00237
	CHEMBL5076254	212642	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		COc1cc(OC)cc(-c2nc(Nc3ccccc3)nc(-c3ccccc3)c2C#N)c1	10.1021/acs.jmedchem.1c01636
	44588517	174577	0	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	377	4	2	7	1.2	CCCn1c(=O)c2[nH]c(-c3ccc(S(C)(=O)=O)cc3)c(O)c2n(C)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457015	174577	0	None	3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	377	4	2	7	1.2	CCCn1c(=O)c2[nH]c(-c3ccc(S(C)(=O)=O)cc3)c(O)c2n(C)c1=O	10.1016/j.bmc.2008.09.067
	22266784	140689	0	None	27	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5cccc(C(F)(F)F)c5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL382929	140689	0	None	27	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5cccc(C(F)(F)F)c5)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11698623	77804	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	478	7	1	7	3.8	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(F)c(C(F)(F)F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL210482	77804	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	478	7	1	7	3.8	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(F)c(C(F)(F)F)c4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	1676	98514	53	None	-3	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1021/jm900413e
	CHEMBL279898	98514	53	None	-3	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	10.1021/jm900413e
	155517938	169649	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	334	3	2	4	2.9	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4445568	169649	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	334	3	2	4	2.9	CC1=C(C(=O)OC(C)C(F)(F)F)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.9b01340
	9901700	190288	0	None	-354	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	322	4	1	8	2.1	COc1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	CHEMBL518497	190288	0	None	-354	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	322	4	1	8	2.1	COc1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	21958565	64113	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5F)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL181346	64113	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	504	9	1	9	4.1	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccccc5F)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	46228017	198109	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	400	8	1	8	2.5	CCSCCn1c(=O)c2[nH]c(Cc3ccco3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL594046	198109	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	400	8	1	8	2.5	CCSCCn1c(=O)c2[nH]c(Cc3ccco3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	10869347	201940	0	None	8	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	270	3	1	5	0.7	Cn1c(=O)n(CCc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	CHEMBL67228	201940	0	None	8	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	270	3	1	5	0.7	Cn1c(=O)n(CCc2ccccc2)c(=O)c2[nH]cnc21	10.1021/jm0104318
	9967620	188380	0	None	-173	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	337	4	1	9	2.0	Nc1nc(-c2ccco2)c2nnn(Cc3cccc([N+](=O)[O-])c3)c2n1	10.1021/jm800961g
	CHEMBL508451	188380	0	None	-173	4	Human	6.2	pKi	=	6.2	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	337	4	1	9	2.0	Nc1nc(-c2ccco2)c2nnn(Cc3cccc([N+](=O)[O-])c3)c2n1	10.1021/jm800961g
	137656644	159124	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	304	3	2	5	2.0	CC1=C(C(=O)OC(C)C)C(c2ccsc2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	CHEMBL4104142	159124	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	304	3	2	5	2.0	CC1=C(C(=O)OC(C)C)C(c2ccsc2)N/C(=N/C#N)N1	10.1021/acs.jmedchem.7b00138
	44281684	109912	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	445	8	2	6	3.6	CCCn1c(=O)c2nc(-c3ccc(NC(=O)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32447	109912	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	445	8	2	6	3.6	CCCn1c(=O)c2nc(-c3ccc(NC(=O)Cc4ccccc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	11091783	83792	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	460	6	2	11	2.6	CCNc1c2c(nc(NC(=O)Cc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL22085	83792	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	460	6	2	11	2.6	CCNc1c2c(nc(NC(=O)Cc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	10659581	28577	0	None	-33	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 56-75Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 56-75	ChEMBL	269	2	1	8	1.3	CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL137879	28577	0	None	-33	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 56-75Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 56-75	ChEMBL	269	2	1	8	1.3	CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	135874428	166990	0	None	7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	9	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4cccc(OC)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL430044	166990	0	None	7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	479	9	2	9	2.5	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4cccc(OC)c4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	176407	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00564
	405	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00564
	CHEMBL113142	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00564
	DB08770	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c00564
	176407	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.1c01636
	405	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.1c01636
	CHEMBL113142	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.1c01636
	DB08770	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.1c01636
	176407	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.5b01586
	405	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.5b01586
	CHEMBL113142	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.5b01586
	DB08770	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.5b01586
	176407	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.7b00138
	405	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.7b00138
	CHEMBL113142	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.7b00138
	DB08770	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.7b00138
	176407	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c01431
	405	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL113142	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c01431
	DB08770	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.0c01431
	176407	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.9b01340
	405	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.9b01340
	CHEMBL113142	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.9b01340
	DB08770	4069	76	None	-34	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10.1021/acs.jmedchem.9b01340
	11496023	138195	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	446	7	1	7	3.0	CCCn1c(=O)c2nc(-c3cnn(Cc4c(F)cc(F)cc4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL378020	138195	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	446	7	1	7	3.0	CCCn1c(=O)c2nc(-c3cnn(Cc4c(F)cc(F)cc4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	155563730	174825	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	334	3	2	4	2.9	CC(C)OC(=O)C1=C(C(F)(F)F)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.9b01340
	CHEMBL4575695	174825	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	334	3	2	4	2.9	CC(C)OC(=O)C1=C(C(F)(F)F)NC(=O)NC1c1ccsc1	10.1021/acs.jmedchem.9b01340
	44284710	99974	0	None	-15	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	376	6	1	6	3.0	CCCn1c(=O)c2nc(-c3ccc(Cl)cc3OC)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL290643	99974	0	None	-15	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	376	6	1	6	3.0	CCCn1c(=O)c2nc(-c3ccc(Cl)cc3OC)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	4675559	103365	4	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	3	1	4	1.8	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL3091714	103365	4	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	264	3	1	4	1.8	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	4675559	103365	4	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	3	1	4	1.8	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccco1	10.1021/ml400185v
	CHEMBL3091714	103365	4	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	3	1	4	1.8	CCOC(=O)C1=C(C)N(C)C(=O)NC1c1ccco1	10.1021/ml400185v
	162663283	181372	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	306	3	2	4	2.9	CC1=C(C(=O)OC2CCCC2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4780036	181372	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	306	3	2	4	2.9	CC1=C(C(=O)OC2CCCC2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	135529396	116064	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	571	9	2	9	3.4	CC(C)Cn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)n(C)n3)[nH]c2n(CC(C)C)c1=O	10.1021/jm0309654
	CHEMBL33653	116064	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	571	9	2	9	3.4	CC(C)Cn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(Br)cc4)n(C)n3)[nH]c2n(CC(C)C)c1=O	10.1021/jm0309654
	11590025	73053	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	429	10	1	8	2.2	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(CC)c(=O)n3CCCOC)cc1	10.1021/jm0506221
	CHEMBL201650	73053	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	429	10	1	8	2.2	CCOC(=O)COc1ccc(-c2cc3c([nH]2)c(=O)n(CC)c(=O)n3CCCOC)cc1	10.1021/jm0506221
	145993107	166346	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	593	15	1	10	3.0	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN3CCCC3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	CHEMBL4286455	166346	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	593	15	1	10	3.0	CCCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN3CCCC3)cc2)n(CCCC)c1=O	10.1039/C8MD00070K
	127043663	140681	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	411	7	1	8	2.3	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(O)cc2)n(CCC)c1=O	10.1016/j.bmc.2016.07.028
	CHEMBL3828658	140681	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	411	7	1	8	2.3	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(O)cc2)n(CCC)c1=O	10.1016/j.bmc.2016.07.028
	162667742	181812	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	312	4	2	4	2.7	CC1=C(C(=O)OCc2ccccc2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4785576	181812	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	312	4	2	4	2.7	CC1=C(C(=O)OCc2ccccc2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	135409793	16280	0	None	-5248	4	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 3580-12400Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 3580-12400	ChEMBL	335	5	1	6	3.1	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(N(C)C)cc3)nn12	10.1021/jm010570p
	CHEMBL123462	16280	0	None	-5248	4	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 3580-12400Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; Range 3580-12400	ChEMBL	335	5	1	6	3.1	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(N(C)C)cc3)nn12	10.1021/jm010570p
	11483771	194035	0	None	-19	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	312	4	2	5	2.4	Nc1nc(C(=O)NCc2ccccc2F)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL557084	194035	0	None	-19	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	312	4	2	5	2.4	Nc1nc(C(=O)NCc2ccccc2F)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	71570217	85706	0	None	-23	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK-293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK-293 cells	ChEMBL	349	5	1	5	3.8	COc1cccc(-c2cc(NC(C)=O)nc(-c3cccc(OC)c3)n2)c1	10.1016/j.ejmech.2012.11.010
	CHEMBL2311741	85706	0	None	-23	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK-293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK-293 cells	ChEMBL	349	5	1	5	3.8	COc1cccc(-c2cc(NC(C)=O)nc(-c3cccc(OC)c3)n2)c1	10.1016/j.ejmech.2012.11.010
	44452536	95438	0	None	-16	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	309	4	2	7	2.3	CC(O)CNc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	CHEMBL259178	95438	0	None	-16	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	309	4	2	7	2.3	CC(O)CNc1nc2ccccc2n2nc(-c3ccco3)nc12	10.1016/j.bmc.2007.10.103
	44588394	174767	0	None	-26	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	327	5	1	6	2.7	CCCn1c(=O)c2c(cc(-c3ccccc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL457441	174767	0	None	-26	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	327	5	1	6	2.7	CCCn1c(=O)c2c(cc(-c3ccccc3)n2O)n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	52948671	19102	0	None	5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	520	11	1	5	4.8	COCCCNC(=O)COc1ccc2c(c1)c(CCc1ccccc1)c(-c1ccc(F)cc1F)c(=O)n2C	10.1016/j.bmcl.2010.10.030
	CHEMBL1290544	19102	0	None	5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	520	11	1	5	4.8	COCCCNC(=O)COc1ccc2c(c1)c(CCc1ccccc1)c(-c1ccc(F)cc1F)c(=O)n2C	10.1016/j.bmcl.2010.10.030
	71680730	89765	0	None	-10	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	338	4	1	5	3.3	COc1cccc(/C=C/C(=O)Nc2nc3ccccc3c(=O)s2)c1	10.1021/jm400336x
	CHEMBL2382431	89765	0	None	-10	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	338	4	1	5	3.3	COc1cccc(/C=C/C(=O)Nc2nc3ccccc3c(=O)s2)c1	10.1021/jm400336x
	44588393	175755	0	None	10	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	349	2	2	7	0.3	Cn1c(=O)c2[nH]c(-c3ccc(S(C)(=O)=O)cc3)c(O)c2n(C)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL459553	175755	0	None	10	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	349	2	2	7	0.3	Cn1c(=O)c2[nH]c(-c3ccc(S(C)(=O)=O)cc3)c(O)c2n(C)c1=O	10.1016/j.bmc.2008.09.067
	156014270	176633	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	354	3	1	7	3.7	CC1=C(C(=O)OC(C)C)C(c2cncs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4635502	176633	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	354	3	1	7	3.7	CC1=C(C(=O)OC(C)C)C(c2cncs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	127038752	136209	0	None	-74	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	466	7	4	13	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(NC(C)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1039/C5MD00086F
	CHEMBL3740959	136209	0	None	-74	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	466	7	4	13	0.5	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(NC(C)Cc5ccccc5)nc43)[C@H](O)[C@@H]2O)n1	10.1039/C5MD00086F
	10065148	98645	0	None	-33	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	329	4	1	9	2.4	CCCSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL280888	98645	0	None	-33	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	329	4	1	9	2.4	CCCSc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	136383804	157539	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	560	9	1	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4086551	157539	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	560	9	1	9	3.8	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	11537425	84944	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	341	4	1	8	3.2	N#Cc1cncc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)c1	10.1021/jm061333v
	CHEMBL226237	84944	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells	ChEMBL	341	4	1	8	3.2	N#Cc1cncc(Nc2ncc(-c3ccncn3)c(-c3ccco3)n2)c1	10.1021/jm061333v
	11711753	165659	0	None	15	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	434	6	2	7	2.3	COc1cc(OCC(=O)Nc2ccccc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	CHEMBL426660	165659	0	None	15	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	434	6	2	7	2.3	COc1cc(OCC(=O)Nc2ccccc2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1021/jm0506221
	44451018	160027	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	535	7	1	7	3.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5Cl)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL411275	160027	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	535	7	1	7	3.5	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5Cl)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	10861697	102551	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	374	7	0	6	3.1	CCCn1c(=O)c2c(nc(-c3ccccc3)n2CCCl)n(CCC)c1=O	10.1021/jm0104318
	CHEMBL307105	102551	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	374	7	0	6	3.1	CCCn1c(=O)c2c(nc(-c3ccccc3)n2CCCl)n(CCC)c1=O	10.1021/jm0104318
	265603	162023	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	301	2	1	7	0.5	Cn1c(=O)c2nc(-c3ccc([N+](=O)[O-])cc3)[nH]c2n(C)c1=O	10.1021/jm0104318
	CHEMBL416884	162023	9	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	301	2	1	7	0.5	Cn1c(=O)c2nc(-c3ccc([N+](=O)[O-])cc3)[nH]c2n(C)c1=O	10.1021/jm0104318
	137175186	138612	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	290	3	1	7	2.2	CCOC(=O)C1=C(C)Nc2ncnn2C1c1ccsc1	10.1021/acs.jmedchem.5b01586
	CHEMBL3787179	138612	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	290	3	1	7	2.2	CCOC(=O)C1=C(C)Nc2ncnn2C1c1ccsc1	10.1021/acs.jmedchem.5b01586
	10226014	94141	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 3H-ZM214385 from human Adenosine A2B receptor expressed in HEK293 cells after 90 minsDisplacement of 3H-ZM214385 from human Adenosine A2B receptor expressed in HEK293 cells after 90 mins	ChEMBL	452	6	2	9	2.4	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c1=O	10.1021/acs.jmedchem.5b01586
	CHEMBL252048	94141	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 3H-ZM214385 from human Adenosine A2B receptor expressed in HEK293 cells after 90 minsDisplacement of 3H-ZM214385 from human Adenosine A2B receptor expressed in HEK293 cells after 90 mins	ChEMBL	452	6	2	9	2.4	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c1=O	10.1021/acs.jmedchem.5b01586
	10226014	94141	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	452	6	2	9	2.4	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL252048	94141	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	452	6	2	9	2.4	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4noc(-c5ccc(Cl)cc5)n4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	46880333	6213	0	None	29	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	279	3	1	4	3.4	CC(=O)Nc1ccc(-c2ccncc2)c(-c2ccco2)n1	10.1016/j.bmcl.2010.01.045
	CHEMBL1081811	6213	0	None	29	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	279	3	1	4	3.4	CC(=O)Nc1ccc(-c2ccncc2)c(-c2ccco2)n1	10.1016/j.bmcl.2010.01.045
	135678052	95320	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	483	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Cl)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	CHEMBL258571	95320	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE2029F20 from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	483	8	2	8	3.2	CCCn1c(=O)c2[nH]c(-c3cc(C)n(CC(=O)Nc4ccc(Cl)cc4)n3)nc2n(CCC)c1=O	10.1016/j.bmc.2007.11.058
	145964662	163875	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	433	8	3	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4213768	163875	0	None	3	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	433	8	3	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	21916389	95467	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	394	5	1	7	1.9	Cn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc21	10.1021/jm7014815
	CHEMBL259300	95467	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]ZM-241385 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	394	5	1	7	1.9	Cn1c(=O)n(CC2CC2)c(=O)c2[nH]c(-c3cnn(Cc4cccc(F)c4)c3)nc21	10.1021/jm7014815
	49797747	10504	0	None	10	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	482	6	1	7	3.4	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCOCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170134	10504	0	None	10	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	482	6	1	7	3.4	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(C(=O)N4CCOCC4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	155551750	174806	0	None	44	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	626	14	2	10	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OCCOCCOC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4575279	174806	0	None	44	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	626	14	2	10	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OCCOCCOC)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44451271	95318	0	None	45	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	542	5	1	8	2.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5c(Cl)cncc5Cl)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL258568	95318	0	None	45	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	542	5	1	8	2.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5c(Cl)cncc5Cl)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	44574194	177843	0	None	2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	460	8	2	6	4.7	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL466021	177843	0	None	2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	460	8	2	6	4.7	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	155566764	175290	0	None	41	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	508	6	2	7	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5)C(C)C4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4586090	175290	0	None	41	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	508	6	2	7	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5)C(C)C4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	44450828	157141	0	None	44	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	472	6	1	6	3.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL408185	157141	0	None	44	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	472	6	1	6	3.1	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc21	10.1016/j.bmc.2008.01.002
	44236602	158476	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	420	5	1	7	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(F)cc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4096746	158476	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	420	5	1	7	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(F)cc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	44236571	155263	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	420	5	1	7	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(F)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4059836	155263	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	420	5	1	7	2.4	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4cccc(F)c4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	44451072	95581	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	543	9	1	7	4.0	CCCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL259874	95581	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	543	9	1	7	4.0	CCCn1c(=O)n(CC(C)C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	44551168	200080	0	None	11	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	370	5	0	8	2.2	CCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL606753	200080	0	None	11	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	370	5	0	8	2.2	CCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	145976828	163115	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	447	9	3	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4204683	163115	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	447	9	3	6	2.2	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCc4ccccc4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	44185932	191013	0	None	11	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	508	7	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL519556	191013	0	None	11	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	508	7	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	66894103	156008	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	569	9	1	7	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)cc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4068421	156008	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	569	9	1	7	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)cc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	56951623	70814	0	None	18	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	331	5	2	6	1.0	CCCn1c(=O)c2[nH]c(-c3cc(=O)[nH]n3C)cc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955923	70814	0	None	18	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	331	5	2	6	1.0	CCCn1c(=O)c2[nH]c(-c3cc(=O)[nH]n3C)cc2n(CCC)c1=O	10.1021/jm201292w
	44185933	186117	0	None	35	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	522	8	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	CHEMBL488541	186117	0	None	35	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	522	8	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/jm900413e
	44450850	95390	0	None	9	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	598	9	1	8	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5c(Cl)cncc5Cl)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL258979	95390	0	None	9	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	598	9	1	8	4.4	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5c(Cl)cncc5Cl)CC4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.01.002
	11498113	72668	0	None	6	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	607	12	2	8	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CS(=O)(=O)N5CCCC5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201008	72668	0	None	6	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	607	12	2	8	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(CS(=O)(=O)N5CCCC5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11664137	72937	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	565	10	2	6	4.3	CCCn1c(=O)c2[nH]c(-c3ccc(N(C=O)CC(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201293	72937	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	565	10	2	6	4.3	CCCn1c(=O)c2[nH]c(-c3ccc(N(C=O)CC(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11604435	74660	0	None	23	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	7	2	6	3.2	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(CC)c1=O	10.1021/jm0506221
	CHEMBL203413	74660	0	None	23	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	432	7	2	6	3.2	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(CC)c1=O	10.1021/jm0506221
	137640112	156129	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	488	8	1	9	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccccc4C(=O)OCC)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4069730	156129	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	488	8	1	9	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccccc4C(=O)OCC)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	44574225	178008	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	462	8	2	8	3.5	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4cnccn4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL467271	178008	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	462	8	2	8	3.5	CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4cnccn4)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2009.03.062
	145973326	164161	0	None	29	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	729	17	3	7	7.0	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCCCCCCCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	CHEMBL4217459	164161	0	None	29	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human adenosine A2B receptor expressed in CHO cell membranes after 75 mins by liquid scintillation counting method	ChEMBL	729	17	3	7	7.0	CCCn1c(=O)[nH]c2nc(-c3ccc(OCC(=O)NCCCCCCCCCCC4=C5C(C)=CC(C)=[N+]5[B-](F)(F)n5c(C)cc(C)c54)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.7b01627
	11562203	72788	0	None	6	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	488	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201157	72788	0	None	6	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	488	9	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	44406891	73181	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	516	9	2	6	5.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)(C)C)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201749	73181	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	516	9	2	6	5.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)(C)C)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	10720065	97932	0	None	1	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	495	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL275427	97932	0	None	1	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	495	9	2	7	4.0	CCCn1c(=O)c2nc(-c3ccc(OCC(=O)Nc4ccc(Cl)cc4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0506221
	168296088	191758	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	352	4	2	6	1.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)F)cc3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5207290	191758	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	352	4	2	6	1.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)F)cc3)[nH]c2c1=O	10.1039/d2md00132b
	11784407	96770	0	None	6	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	364	5	3	6	1.1	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)O)cc3)nc2c1=O	10.1021/jm0310030
	CHEMBL268617	96770	0	None	6	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	364	5	3	6	1.1	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)O)cc3)nc2c1=O	10.1021/jm0310030
	CHEMBL36952	96770	0	None	6	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranesBinding affinity for human adenosine A2B receptor using [3H]ZM-241385 in CHO cell membranes	ChEMBL	364	5	3	6	1.1	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)O)cc3)nc2c1=O	10.1021/jm0310030
	135465776	99246	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	470	9	2	9	2.5	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)no3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL284789	99246	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	470	9	2	9	2.5	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(F)cc4)no3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10647227	164891	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 56-89Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 56-89	ChEMBL	450	6	2	8	4.8	CCCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL423934	164891	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 56-89Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 56-89	ChEMBL	450	6	2	8	4.8	CCCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	10647227	164891	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 56-89Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 56-89	ChEMBL	450	6	2	8	4.8	CCCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL423934	164891	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 56-89Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 56-89	ChEMBL	450	6	2	8	4.8	CCCCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	52946114	19062	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	525	9	2	6	5.7	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(COc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	CHEMBL1290325	19062	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	525	9	2	6	5.7	CC(C)(NC(=O)COc1ccc2[nH]c(=O)c(-c3nccs3)c(COc3ccccc3)c2c1)c1ccccc1	10.1016/j.bmcl.2010.10.030
	52945098	19142	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	504	9	1	6	3.4	Cn1c(=O)c(S(C)(=O)=O)c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccccc3)ccc21	10.1016/j.bmcl.2010.10.030
	CHEMBL1290782	19142	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	504	9	1	6	3.4	Cn1c(=O)c(S(C)(=O)=O)c(CCc2ccccc2)c2cc(OCC(=O)NCc3ccccc3)ccc21	10.1016/j.bmcl.2010.10.030
	11784407	96770	0	None	6	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	364	5	3	6	1.1	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL268617	96770	0	None	6	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	364	5	3	6	1.1	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	CHEMBL36952	96770	0	None	6	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	364	5	3	6	1.1	CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)O)cc3)nc2c1=O	10.1021/jm011049y
	135515507	33887	0	None	-4	4	Human	7.2	pKi	=	7.2	Binding	Tested for inhibitory activity against Adenosine A2b receptor by displacement of [3H]DPCPX expressed in CHO cells; value ranges from 61-80Tested for inhibitory activity against Adenosine A2b receptor by displacement of [3H]DPCPX expressed in CHO cells; value ranges from 61-80	ChEMBL	394	3	3	7	3.6	O=C(Nc1cccc(Cl)c1)Nc1nc2n[nH]cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL142562	33887	0	None	-4	4	Human	7.2	pKi	=	7.2	Binding	Tested for inhibitory activity against Adenosine A2b receptor by displacement of [3H]DPCPX expressed in CHO cells; value ranges from 61-80Tested for inhibitory activity against Adenosine A2b receptor by displacement of [3H]DPCPX expressed in CHO cells; value ranges from 61-80	ChEMBL	394	3	3	7	3.6	O=C(Nc1cccc(Cl)c1)Nc1nc2n[nH]cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	45269769	194888	0	None	7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	404	7	1	6	3.3	CCn1c(=O)c2[nH]c(-c3ccc(-c4ccccc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL563889	194888	0	None	7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	404	7	1	6	3.3	CCn1c(=O)c2[nH]c(-c3ccc(-c4ccccc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11567699	73293	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	408	6	2	7	1.5	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccco4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL201796	73293	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	408	6	2	7	1.5	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccco4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	44451128	160742	0	None	10	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	521	5	1	7	3.0	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)N1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2008.01.002
	CHEMBL412275	160742	0	None	10	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	521	5	1	7	3.0	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)N1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2008.01.002
	168281755	190301	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	368	5	2	7	1.1	CCCn1c(=O)[nH]c2nc(-c3cccc(OS(=O)(=O)F)c3)[nH]c2c1=O	10.1039/d2md00132b
	CHEMBL5185103	190301	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane preincubated for 4 hrs followed by [3H]PSB-603 addition and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	368	5	2	7	1.1	CCCn1c(=O)[nH]c2nc(-c3cccc(OS(=O)(=O)F)c3)[nH]c2c1=O	10.1039/d2md00132b
	21958702	129120	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(C)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL367351	129120	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5cccc(C)c5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	11495641	138721	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	428	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(F)cc4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL379032	138721	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	428	7	1	7	2.9	CCCn1c(=O)c2nc(-c3cnn(Cc4ccc(F)cc4F)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	11618368	3774	68	None	-501	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/acs.jmedchem.0c00237
	5611	3774	68	None	-501	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/acs.jmedchem.0c00237
	CHEMBL2105747	3774	68	None	-501	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/acs.jmedchem.0c00237
	DB12203	3774	68	None	-501	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of human adenosine 2B receptorInhibition of human adenosine 2B receptor	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/acs.jmedchem.0c00237
	11618368	3774	68	None	-501	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/jm4011669
	5611	3774	68	None	-501	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/jm4011669
	CHEMBL2105747	3774	68	None	-501	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/jm4011669
	DB12203	3774	68	None	-501	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	406	3	2	7	2.5	COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1	10.1021/jm4011669
	2153	3728	108	None	-21	14	Human	5.2	pKi	=	5.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmcl.2004.11.044
	2620	3728	108	None	-21	14	Human	5.2	pKi	=	5.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmcl.2004.11.044
	413	3728	108	None	-21	14	Human	5.2	pKi	=	5.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmcl.2004.11.044
	CHEMBL190	3728	108	None	-21	14	Human	5.2	pKi	=	5.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmcl.2004.11.044
	DB00277	3728	108	None	-21	14	Human	5.2	pKi	=	5.2	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 radioligand in membranes from HEK-A2B cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmcl.2004.11.044
	156014687	176676	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	2	6	2.6	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cc[nH]n1	10.1021/acs.jmedchem.0c00564
	CHEMBL4636116	176676	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	2	6	2.6	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cc[nH]n1	10.1021/acs.jmedchem.0c00564
	456309	160093	15	None	-114	4	Human	5.2	pKi	=	5.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	378	2	2	3	4.4	O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN1	10.1021/jm4011669
	CHEMBL411329	160093	15	None	-114	4	Human	5.2	pKi	=	5.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	378	2	2	3	4.4	O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN1	10.1021/jm4011669
	156009812	176476	0	None	-707	2	Human	6.2	pKi	=	6.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2ncco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4632760	176476	0	None	-707	2	Human	6.2	pKi	=	6.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2ncco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	44588514	174485	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	369	6	2	6	2.9	CCCn1c(=O)c2[nH]c(-c3ccc(C(C)=O)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL456816	174485	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	369	6	2	6	2.9	CCCn1c(=O)c2[nH]c(-c3ccc(C(C)=O)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	52949999	18918	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	572	9	1	5	5.1	CN(Cc1ccc(Cl)c(Cl)c1)C(=O)COc1ccc2[nH]c(=O)c(S(C)(=O)=O)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	CHEMBL1289343	18918	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor transfected in CHO cells after 60 mins by scintillation counting	ChEMBL	572	9	1	5	5.1	CN(Cc1ccc(Cl)c(Cl)c1)C(=O)COc1ccc2[nH]c(=O)c(S(C)(=O)=O)c(CCc3ccccc3)c2c1	10.1016/j.bmcl.2010.10.030
	156015964	177040	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccno1	10.1021/acs.jmedchem.0c00564
	CHEMBL4641123	177040	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccno1	10.1021/acs.jmedchem.0c00564
	72546298	103362	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	4	2	4	1.9	CCOC(=O)C1=C(CC)NC(=O)NC1c1ccco1	10.1021/ml400185v
	CHEMBL3091710	103362	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysisDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by Scatchard plot analysis	ChEMBL	264	4	2	4	1.9	CCOC(=O)C1=C(CC)NC(=O)NC1c1ccco1	10.1021/ml400185v
	46880473	5987	0	None	19	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	305	4	1	5	2.7	O=C(Nc1ccc(-c2ccncc2)c(-n2cccn2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1080679	5987	0	None	19	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	305	4	1	5	2.7	O=C(Nc1ccc(-c2ccncc2)c(-n2cccn2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	11531449	71892	0	None	12	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	401	9	2	7	1.7	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc2n(CCCOC)c1=O	10.1021/jm0506221
	CHEMBL198191	71892	0	None	12	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	401	9	2	7	1.7	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)cc2n(CCCOC)c1=O	10.1021/jm0506221
	44437214	168677	0	None	-31	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	355	3	1	8	0.6	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccc(O)cc2)n(C)c1=O	10.1016/j.bmc.2007.07.051
	CHEMBL441145	168677	0	None	-31	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells	ChEMBL	355	3	1	8	0.6	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccc(O)cc2)n(C)c1=O	10.1016/j.bmc.2007.07.051
	9834769	156692	2	None	-457	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	247	2	0	5	3.4	CCc1nc(-c2nccs2)c2sccc2n1	10.1016/j.bmcl.2008.03.076
	CHEMBL407650	156692	2	None	-457	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	247	2	0	5	3.4	CCc1nc(-c2nccs2)c2sccc2n1	10.1016/j.bmcl.2008.03.076
	156019063	177253	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2ccon2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4644043	177253	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	338	3	1	7	3.3	CC1=C(C(=O)OC(C)C)C(c2ccon2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	162667072	181817	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	292	4	2	4	2.3	CC1=C(C(=O)OCC2CC2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4785646	181817	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	292	4	2	4	2.3	CC1=C(C(=O)OCC2CC2)C(c2ccsc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	127030660	138488	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	303	3	1	6	3.2	CC1=C(C(=O)OC(C)C)C(c2cccs2)n2ccnc2N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785876	138488	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	303	3	1	6	3.2	CC1=C(C(=O)OC(C)C)C(c2cccs2)n2ccnc2N1	10.1021/acs.jmedchem.5b01586
	22266730	94114	0	None	29	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	354	4	2	6	1.5	CCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL251875	94114	0	None	29	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	354	4	2	6	1.5	CCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	1329	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.7b00138
	386	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.7b00138
	CHEMBL183	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.7b00138
	DB12946	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.7b00138
	15667089	4534	0	None	-33	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	276	3	1	5	1.6	CCn1c(=O)c2nc(C3CCCC3)[nH]c2n(CC)c1=O	10.1021/acs.jmedchem.9b01340
	CHEMBL102859	4534	0	None	-33	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	276	3	1	5	1.6	CCn1c(=O)c2nc(C3CCCC3)[nH]c2n(CC)c1=O	10.1021/acs.jmedchem.9b01340
	1329	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.0c00564
	386	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.0c00564
	CHEMBL183	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.0c00564
	DB12946	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.0c00564
	1329	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.1c01636
	386	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.1c01636
	CHEMBL183	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.1c01636
	DB12946	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.1c01636
	1329	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.5b01586
	386	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.5b01586
	CHEMBL183	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.5b01586
	DB12946	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.5b01586
	CHEMBL5074986	212567	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysisDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis	ChEMBL		None	None	None		N#Cc1c(-c2cccc(Cl)c2)nc(N)nc1-c1cccc(Cl)c1	10.1021/acs.jmedchem.1c01636
	155542822	172586	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccco1	10.1021/acs.jmedchem.9b01340
	CHEMBL4521818	172586	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	377	3	1	6	4.0	CCOC(=O)C1=C(C(F)(F)F)Nc2nc3ccccc3n2C1c1ccco1	10.1021/acs.jmedchem.9b01340
	1329	1439	78	None	-1288	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.0c01431
	386	1439	78	None	-1288	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.0c01431
	CHEMBL183	1439	78	None	-1288	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.0c01431
	DB12946	1439	78	None	-1288	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	10.1021/acs.jmedchem.0c01431
	162671640	182263	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	290	4	2	4	2.3	CC1=C(C(=O)OCC2CCC2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4791578	182263	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	290	4	2	4	2.3	CC1=C(C(=O)OCC2CCC2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	135421366	108467	0	None	13	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	521	11	2	9	3.6	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C(C)CC)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32118	108467	0	None	13	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	521	11	2	9	3.6	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C(C)CC)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	44406592	72512	0	None	4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5C(F)(F)F)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200313	72512	0	None	4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	528	8	1	10	3.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5C(F)(F)F)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11711190	77423	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	406	8	1	7	2.8	CCCn1c(=O)c2nc(-c3cnn(CCc4ccccc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL209217	77423	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	406	8	1	7	2.8	CCCn1c(=O)c2nc(-c3cnn(CCc4ccccc4)c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	21874581	169037	0	None	-138	4	Human	6.1	pKi	=	6.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	322	4	1	8	2.1	COc1ccccc1Cn1nnc2c(-c3ccco3)nc(N)nc21	10.1021/jm800961g
	CHEMBL443665	169037	0	None	-138	4	Human	6.1	pKi	=	6.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	322	4	1	8	2.1	COc1ccccc1Cn1nnc2c(-c3ccco3)nc(N)nc21	10.1021/jm800961g
	9497523	180767	0	None	-53	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	267	2	1	5	3.5	N#Cc1c(-c2cccs2)cc(-c2ccco2)nc1N	10.1021/jm701594y
	CHEMBL476311	180767	0	None	-53	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneDisplacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membrane	ChEMBL	267	2	1	5	3.5	N#Cc1c(-c2cccs2)cc(-c2ccco2)nc1N	10.1021/jm701594y
	156020575	177481	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	354	3	1	7	3.7	CC1=C(C(=O)OC(C)C)C(c2nccs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	CHEMBL4647365	177481	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	354	3	1	7	3.7	CC1=C(C(=O)OC(C)C)C(c2nccs2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.0c00564
	11426423	193421	0	None	-177	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	295	4	2	6	1.6	Nc1nc(C(=O)NCc2ccccn2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL549885	193421	0	None	-177	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	295	4	2	6	1.6	Nc1nc(C(=O)NCc2ccccn2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	11850015	79735	0	None	-72	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins	ChEMBL	367	3	0	6	3.5	Cc1nn(Cc2ccccc2)c(=O)c2ncn3nc(-c4ccccc4)cc3c12	10.1016/j.bmc.2010.09.043
	CHEMBL213425	79735	0	None	-72	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins	ChEMBL	367	3	0	6	3.5	Cc1nn(Cc2ccccc2)c(=O)c2ncn3nc(-c4ccccc4)cc3c12	10.1016/j.bmc.2010.09.043
	19074239	202149	6	None	-6	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	320	10	1	5	3.0	CCCCCCn1c(=O)c2nc[nH]c2n(CCCCCC)c1=O	10.1021/jm0104318
	CHEMBL68660	202149	6	None	-6	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	320	10	1	5	3.0	CCCCCCn1c(=O)c2nc[nH]c2n(CCCCCC)c1=O	10.1021/jm0104318
	135522362	99546	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	472	8	1	10	0.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(C)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL286838	99546	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsBinding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors	ChEMBL	472	8	1	10	0.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(C)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135522362	99546	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	472	8	1	10	0.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(C)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL286838	99546	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	472	8	1	10	0.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(C)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10895416	56874	0	None	-7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 56-103Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 56-103	ChEMBL	436	5	2	8	4.4	CCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL164905	56874	0	None	-7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 56-103Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 56-103	ChEMBL	436	5	2	8	4.4	CCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	136042345	70812	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	585	8	2	9	4.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C(F)(F)F)cc(C(F)(F)F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955921	70812	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	585	8	2	9	4.9	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(C(F)(F)F)cc(C(F)(F)F)cc5[nH]4)no3)nc2n(CCC)c1=O	10.1021/jm201292w
	11438116	84230	4	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	303	4	1	3	4.2	CCC(=O)Nc1cc(-c2ccccc2)nc(-c2ccccc2)n1	10.1021/jm100843z
	CHEMBL222474	84230	4	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	303	4	1	3	4.2	CCC(=O)Nc1cc(-c2ccccc2)nc(-c2ccccc2)n1	10.1021/jm100843z
	377	2707	47	None	-1479	15	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	425	2707	47	None	-1479	15	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	448222	2707	47	None	-1479	15	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	CHEMBL464859	2707	47	None	-1479	15	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsInhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm031143+
	44410550	75892	0	None	-5888	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	511	7	5	12	0.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4ccccc4[N+](=O)[O-])nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL205850	75892	0	None	-5888	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	511	7	5	12	0.0	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)c4ccccc4[N+](=O)[O-])nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	156019196	177369	0	None	-389	2	Human	6.1	pKi	=	6.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ncco1	10.1021/acs.jmedchem.0c00564
	CHEMBL4645754	177369	0	None	-389	2	Human	6.1	pKi	=	6.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ncco1	10.1021/acs.jmedchem.0c00564
	66892978	158670	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	519	9	2	9	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(=O)O)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4098853	158670	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	519	9	2	9	2.3	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(=O)O)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	45269706	194388	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	469	10	2	8	2.0	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NC4CCCC4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL560623	194388	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	469	10	2	8	2.0	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NC4CCCC4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	11555937	139879	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	564	11	2	7	5.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)c5ccccc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL380901	139879	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	564	11	2	7	5.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(=O)c5ccccc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	135416050	99631	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	494	9	2	10	2.2	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc([N+](=O)[O-])cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL287493	99631	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	494	9	2	10	2.2	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc([N+](=O)[O-])cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135529373	111861	0	None	24	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	485	8	2	8	2.6	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(F)c(F)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32950	111861	0	None	24	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	485	8	2	8	2.6	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(F)c(F)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10994183	119714	0	None	-154	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 57-105Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 57-105	ChEMBL	460	6	2	10	3.9	CCCCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL352192	119714	0	None	-154	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 57-105Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 57-105	ChEMBL	460	6	2	10	3.9	CCCCn1cc2c(nc(NC(=O)Nc3ccc4c(c3)OCO4)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	11091632	119441	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 65-94Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 65-94	ChEMBL	450	6	2	8	4.8	CCCCn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL349716	119441	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 65-94Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 65-94	ChEMBL	450	6	2	8	4.8	CCCCn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	46880421	6281	0	None	4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	322	4	1	5	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2cncs2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	CHEMBL1082171	6281	0	None	4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	322	4	1	5	3.6	O=C(Nc1ccc(-c2ccncc2)c(-c2cncs2)n1)C1CC1	10.1016/j.bmcl.2010.01.045
	2153	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	2620	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	413	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	CHEMBL190	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	DB00277	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm900413e
	156018198	177247	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccon1	10.1021/acs.jmedchem.0c00564
	CHEMBL4643944	177247	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccon1	10.1021/acs.jmedchem.0c00564
	137645670	157443	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	424	6	2	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CC4(O)CCCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4085353	157443	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	424	6	2	8	1.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CC4(O)CCCC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	21874603	178001	0	None	-34	4	Human	7.1	pKi	=	7.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	328	3	1	7	2.4	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(F)c3F)c2n1	10.1021/jm800961g
	CHEMBL467244	178001	0	None	-34	4	Human	7.1	pKi	=	7.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	328	3	1	7	2.4	Nc1nc(-c2ccco2)c2nnn(Cc3cccc(F)c3F)c2n1	10.1021/jm800961g
	11561747	72728	0	None	6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	463	8	2	6	3.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)c(Br)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201108	72728	0	None	6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	463	8	2	6	3.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)O)cc3)c(Br)c2n(CCC)c1=O	10.1021/jm0506221
	11524078	73180	0	None	8	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	396	5	2	6	1.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NC4CCCC4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	CHEMBL201745	73180	0	None	8	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	396	5	2	6	1.7	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NC4CCCC4)cc3)cc2n(C)c1=O	10.1021/jm0506221
	155525396	170514	0	None	-7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assayDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assay	ChEMBL	295	2	2	5	2.7	Oc1ccc(-c2nc(N3CCCCC3)c3nc[nH]c3n2)cc1	10.1016/j.bmc.2019.06.034
	CHEMBL4457537	170514	0	None	-7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assayDisplacement of [3H]DPCPX from human A2B receptor expressed in HEK-293-A2B cells incubated for 30 mins by scintillation counting method based radioligand competitive binding assay	ChEMBL	295	2	2	5	2.7	Oc1ccc(-c2nc(N3CCCCC3)c3nc[nH]c3n2)cc1	10.1016/j.bmc.2019.06.034
	46837703	10478	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	458	6	2	5	3.1	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	CHEMBL1169972	10478	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	458	6	2	5	3.1	CCCn1c(=O)[nH]c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc21	10.1016/j.ejmech.2010.03.011
	14000474	50712	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	314	5	1	7	1.2	CCCn1c(=O)c2nc(-c3cnccn3)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	CHEMBL157836	50712	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	314	5	1	7	1.2	CCCn1c(=O)c2nc(-c3cnccn3)[nH]c2n(CCC)c1=O	10.1021/jm0104318
	44410697	76917	0	None	-4265	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	458	6	5	10	-0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)C4CCCC4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL208160	76917	0	None	-4265	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	458	6	5	10	-0.1	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)C4CCCC4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	44520982	198156	0	None	-794	4	Human	6.1	pKi	=	6.1	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	298	4	3	6	1.3	Cc1ccc(-c2cc(C(=O)NCc3ncc[nH]3)nc(N)n2)o1	10.1016/j.bmc.2009.07.078
	CHEMBL594363	198156	0	None	-794	4	Human	6.1	pKi	=	6.1	Binding	Displacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation countingDisplacement of radioligand from human adenosine A2B receptor expressed in cells by topcount microplate scintillation counting	ChEMBL	298	4	3	6	1.3	Cc1ccc(-c2cc(C(=O)NCc3ncc[nH]3)nc(N)n2)o1	10.1016/j.bmc.2009.07.078
	69030489	158887	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	489	8	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4101208	158887	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	489	8	1	8	2.9	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	10158974	154956	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	418	5	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	CHEMBL404168	154956	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranesDisplacement of [3H]-ZM241385 from human A2B receptor expressed in HEK293 cell membranes	ChEMBL	418	5	2	6	2.8	CCCn1c(=O)[nH]c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O	10.1016/j.bmcl.2008.01.008
	11952670	6244	0	None	44	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	278	2	2	6	2.3	Nc1n[nH]c2nc(-c3ccco3)c(-c3ccncn3)cc12	10.1016/j.bmcl.2010.01.077
	CHEMBL1082001	6244	0	None	44	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	278	2	2	6	2.3	Nc1n[nH]c2nc(-c3ccco3)c(-c3ccncn3)cc12	10.1016/j.bmcl.2010.01.077
	46911060	10533	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12	10.1016/j.bmcl.2011.02.053
	CHEMBL1170367	10533	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hrDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12	10.1016/j.bmcl.2011.02.053
	46911060	10533	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1170367	10533	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	373	5	1	7	2.7	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccnn3C)sc12	10.1016/j.bmcl.2010.05.056
	49797771	10739	0	None	9	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	435	6	1	7	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4ccnc4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	CHEMBL1172275	10739	0	None	9	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation countingDisplacement of [3H]ZM241385 from human adenosine A2B receptor expressed in CHO cells after 1 hr by scintillation counting	ChEMBL	435	6	1	7	4.1	CCN(C(C)=O)c1ccc(OC)c2nc(NC(=O)c3ccc(-n4ccnc4)cc3)sc12	10.1016/j.bmcl.2010.05.056
	156012446	176752	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cocn1	10.1021/acs.jmedchem.0c00564
	CHEMBL4637285	176752	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	324	3	1	7	2.9	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cocn1	10.1021/acs.jmedchem.0c00564
	136042353	70794	0	None	70	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	530	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(F)(F)F)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955902	70794	0	None	70	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	530	8	2	9	3.6	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(F)(F)F)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	44451269	95806	0	None	33	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	565	5	1	7	3.1	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)N1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2008.01.002
	CHEMBL261068	95806	0	None	33	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	565	5	1	7	3.1	CC(Oc1ccc(-c2cc3c([nH]2)c(=O)n(C)c(=O)n3C)cc1)C(=O)N1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2008.01.002
	11270783	1195	25	None	67	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm201292w
	5615	1195	25	None	67	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm201292w
	CHEMBL260933	1195	25	None	67	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm201292w
	DB05936	1195	25	None	67	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [125I]-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	10.1021/jm201292w
	155565911	175194	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	522	7	2	7	2.6	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(C(C)c5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4583860	175194	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	522	7	2	7	2.6	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(C(C)c5ccccc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	155548264	173186	0	None	-4	3	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	542	6	1	8	2.7	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)nc2n(C)c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4537196	173186	0	None	-4	3	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant mouse A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	542	6	1	8	2.7	CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)nc2n(C)c1=O	10.1021/acs.jmedchem.9b00071
	66894029	157577	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	570	9	1	8	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4087139	157577	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	570	9	1	8	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)nc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	44450829	95420	0	None	41	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	444	4	1	6	2.2	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259105	95420	0	None	41	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	444	4	1	6	2.2	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	154701278	169327	1	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)O[C@@H](C)C(F)(F)F)[C@@H](c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	CHEMBL4440908	169327	1	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assayDisplacement of [3H]DPCPX from human recombinant A2B receptor expressed in human HEK293 cell membranes incubated for 30 mins by radioligand binding competition assay	ChEMBL	391	3	1	6	4.4	CC1=C(C(=O)O[C@@H](C)C(F)(F)F)[C@@H](c2ccco2)n2c(nc3ccccc32)N1	10.1021/acs.jmedchem.9b01340
	11313397	174127	0	None	18	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	326	5	2	5	2.6	CCCn1c(=O)c2[nH]c(-c3ccc(N)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL455986	174127	0	None	18	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	326	5	2	5	2.6	CCCn1c(=O)c2[nH]c(-c3ccc(N)cc3)cc2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	11677816	72757	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	506	9	2	6	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201128	72757	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	506	9	2	6	4.9	CCCn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	11541413	137949	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	566	12	2	7	5.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OCc5ccccc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL377485	137949	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	566	12	2	7	5.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(OCc5ccccc5)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	54768602	80572	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	331	1	0	7	1.4	Cn1c(=O)c2c(nc3n2CCN3C2CCCCCCC2)n(C)c1=O	10.1016/j.ejmech.2011.05.023
	CHEMBL2153629	80572	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	331	1	0	7	1.4	Cn1c(=O)c2c(nc3n2CCN3C2CCCCCCC2)n(C)c1=O	10.1016/j.ejmech.2011.05.023
	162664296	181488	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	259	2	2	4	2.4	CC1=C(c2ncc(C)o2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4781559	181488	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	259	2	2	4	2.4	CC1=C(c2ncc(C)o2)C(c2ccoc2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	71683094	89764	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	328	4	1	4	3.4	O=C(CCc1ccccc1F)Nc1nc2ccccc2c(=O)s1	10.1021/jm400336x
	CHEMBL2382428	89764	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysisDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	ChEMBL	328	4	1	4	3.4	O=C(CCc1ccccc1F)Nc1nc2ccccc2c(=O)s1	10.1021/jm400336x
	10505816	30125	0	None	-3	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 719-895Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 719-895	ChEMBL	508	8	2	9	5.0	COc1ccc(NC(=O)Nc2nc3nn(CCCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	CHEMBL139182	30125	0	None	-3	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 719-895Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 719-895	ChEMBL	508	8	2	9	5.0	COc1ccc(NC(=O)Nc2nc3nn(CCCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	162673763	182485	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	248	4	2	3	2.3	CCCC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL4794386	182485	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	248	4	2	3	2.3	CCCC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	135522364	99434	0	None	17	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	480	8	3	9	2.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)Nc4ccc(OC)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL286102	99434	0	None	17	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	480	8	3	9	2.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)Nc4ccc(OC)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	10859484	77290	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	298	3	2	9	1.3	CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL20888	77290	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	298	3	2	9	1.3	CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	CHEMBL544678	77290	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	298	3	2	9	1.3	CCNc1c2c(nc(N)n3nc(-c4ccco4)nc23)nn1C	10.1021/jm021023m
	9868991	118471	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 70-94Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 70-94	ChEMBL	462	5	2	8	5.0	CC(C)=CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL342500	118471	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 70-94Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 70-94	ChEMBL	462	5	2	8	5.0	CC(C)=CCn1cc2c(nc(NC(=O)Nc3cccc(Cl)c3)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	10791347	164601	0	None	-7	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 70-94Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 70-94	ChEMBL	494	7	2	9	4.6	COc1ccc(NC(=O)Nc2nc3nn(CCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	CHEMBL422820	164601	0	None	-7	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 70-94Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 70-94	ChEMBL	494	7	2	9	4.6	COc1ccc(NC(=O)Nc2nc3nn(CCc4ccccc4)cc3c3nc(-c4ccco4)nn23)cc1	10.1021/jm001047y
	44574167	178119	0	None	6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	405	4	2	7	2.4	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL468296	178119	0	None	6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	405	4	2	7	2.4	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccccn4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	12295530	99303	12	None	3	3	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	228	1	3	3	0.6	O=c1[nH]c(=O)c2[nH]c(-c3ccccc3)nc2[nH]1	10.1021/jm011049y
	CHEMBL285191	99303	12	None	3	3	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptorInhibition of [3H]ZM-241385 binding to human adenosine A2B receptor	ChEMBL	228	1	3	3	0.6	O=c1[nH]c(=O)c2[nH]c(-c3ccccc3)nc2[nH]1	10.1021/jm011049y
	45486932	195331	2	None	-6	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to adenosine A2B receptor (unknown origin)Binding affinity to adenosine A2B receptor (unknown origin)	ChEMBL	267	5	1	5	2.5	CCn1cnc2c(NCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	CHEMBL567012	195331	2	None	-6	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to adenosine A2B receptor (unknown origin)Binding affinity to adenosine A2B receptor (unknown origin)	ChEMBL	267	5	1	5	2.5	CCn1cnc2c(NCCc3ccccc3)ncnc21	10.1039/C5MD00034C
	137175187	138424	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	3	1	7	2.6	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2ncnc2N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785256	138424	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	304	3	1	7	2.6	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2ncnc2N1	10.1021/acs.jmedchem.5b01586
	44406555	72503	0	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5OC)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL200278	72503	0	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5OC)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	44406562	133666	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5cccc(OC)c5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL371676	133666	0	None	7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5cccc(OC)c5)no4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	22266738	165720	0	None	6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	493	8	1	9	3.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccc(Cl)cc5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL427016	165720	0	None	6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	493	8	1	9	3.9	CCCn1c(=O)c2nc(-c3cnn(Cc4cc(-c5ccc(Cl)cc5)on4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	5353365	1180	25	None	-263	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	330	2	0	6	1.8	Clc1cccc(c1)/C=C/c1nc2c(n1C)c(=O)n(c(=O)n2C)C	10.1021/jm400336x
	5609	1180	25	None	-263	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	330	2	0	6	1.8	Clc1cccc(c1)/C=C/c1nc2c(n1C)c(=O)n(c(=O)n2C)C	10.1021/jm400336x
	CHEMBL26138	1180	25	None	-263	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsDisplacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	ChEMBL	330	2	0	6	1.8	Clc1cccc(c1)/C=C/c1nc2c(n1C)c(=O)n(c(=O)n2C)C	10.1021/jm400336x
	44236417	158134	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	452	7	1	9	0.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCN(C)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4093116	158134	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	452	7	1	9	0.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC#CCN4CCN(C)CC4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2017.04.014
	21958814	135108	0	None	11	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccccc5OC)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	CHEMBL372951	135108	0	None	11	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cellsDisplacement of [3H]ZM-241385 from Adenosine A2B receptor expressed in HEK cells	ChEMBL	490	9	1	11	2.7	CCCn1c(=O)c2nc(-c3cnn(Cc4noc(-c5ccccc5OC)n4)c3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2005.10.002
	11706151	71677	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	508	10	2	6	4.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccccc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL197605	71677	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	508	10	2	6	4.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCc4ccccc4)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	11519361	74647	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	528	9	2	6	5.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4Cl)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL203359	74647	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	528	9	2	6	5.3	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4Cl)cc3)c(Cl)c2n(CCC)c1=O	10.1021/jm0506221
	46228016	200172	0	None	-2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	410	8	1	7	2.9	CCSCCn1c(=O)c2[nH]c(Cc3ccccc3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL607258	200172	0	None	-2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	410	8	1	7	2.9	CCSCCn1c(=O)c2[nH]c(Cc3ccccc3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	12150	2292	2	None	-100	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]MRS1754 from A2BAR (unknown origin) expressed in HEK293 cells assessed as inhibition constant by competitive binding assayDisplacement of [3H]MRS1754 from A2BAR (unknown origin) expressed in HEK293 cells assessed as inhibition constant by competitive binding assay	ChEMBL	399	4	3	9	1.9	O[C@H]1[C@@H](O)[C@H](n2c3nc(C#CCCCC)nc(N)c3nc2c2cccs2)OC1	10.1021/acs.jmedchem.2c00462
	164885960	2292	2	None	-100	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]MRS1754 from A2BAR (unknown origin) expressed in HEK293 cells assessed as inhibition constant by competitive binding assayDisplacement of [3H]MRS1754 from A2BAR (unknown origin) expressed in HEK293 cells assessed as inhibition constant by competitive binding assay	ChEMBL	399	4	3	9	1.9	O[C@H]1[C@@H](O)[C@H](n2c3nc(C#CCCCC)nc(N)c3nc2c2cccs2)OC1	10.1021/acs.jmedchem.2c00462
	CHEMBL5203469	2292	2	None	-100	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]MRS1754 from A2BAR (unknown origin) expressed in HEK293 cells assessed as inhibition constant by competitive binding assayDisplacement of [3H]MRS1754 from A2BAR (unknown origin) expressed in HEK293 cells assessed as inhibition constant by competitive binding assay	ChEMBL	399	4	3	9	1.9	O[C@H]1[C@@H](O)[C@H](n2c3nc(C#CCCCC)nc(N)c3nc2c2cccs2)OC1	10.1021/acs.jmedchem.2c00462
	25188209	178172	0	None	-20	4	Human	6.1	pKi	=	6.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	311	3	1	8	1.6	Nc1nc(-c2ncco2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	CHEMBL468701	178172	0	None	-20	4	Human	6.1	pKi	=	6.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	311	3	1	8	1.6	Nc1nc(-c2ncco2)c2nnn(Cc3ccccc3F)c2n1	10.1021/jm800961g
	135543600	16139	0	None	-933	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; range 640-1100Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; range 640-1100	ChEMBL	336	6	1	6	3.4	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(OCC)cc3)nn12	10.1021/jm010570p
	CHEMBL122819	16139	0	None	-933	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; range 640-1100Inhibition of [3H]DPCPX binding to human Adenosine A2B receptor expressed in HEK cells; range 640-1100	ChEMBL	336	6	1	6	3.4	CCCCc1nc2[nH]cnc2c2nc(-c3ccc(OCC)cc3)nn12	10.1021/jm010570p
	21874641	189255	0	None	-52	4	Human	7.1	pKi	=	7.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	323	3	3	9	1.4	Nc1nc(-c2ccco2)c2nnn(Cc3ccc(N)c(O)c3)c2n1	10.1021/jm800961g
	CHEMBL516770	189255	0	None	-52	4	Human	7.1	pKi	=	7.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	323	3	3	9	1.4	Nc1nc(-c2ccco2)c2nnn(Cc3ccc(N)c(O)c3)c2n1	10.1021/jm800961g
	2748297	181110	12	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	4	2.2	CCC(C)OC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL4776764	181110	12	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	278	4	2	4	2.2	CCC(C)OC(=O)C1=C(C)NC(=O)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	127030064	138434	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	303	3	1	6	3.2	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2ccnc2N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785334	138434	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	303	3	1	6	3.2	CC1=C(C(=O)OC(C)C)C(c2ccsc2)n2ccnc2N1	10.1021/acs.jmedchem.5b01586
	44410691	137646	0	None	-15848	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	460	9	5	10	0.3	CCCCC[C@H](O)C#Cc1nc(NCC)c2ncn([C@@H]3O[C@H](C(=O)NCC)[C@@H](O)[C@H]3O)c2n1	10.1016/j.bmcl.2006.01.110
	CHEMBL376968	137646	0	None	-15848	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	460	9	5	10	0.3	CCCCC[C@H](O)C#Cc1nc(NCC)c2ncn([C@@H]3O[C@H](C(=O)NCC)[C@@H](O)[C@H]3O)c2n1	10.1016/j.bmcl.2006.01.110
	135430228	109816	0	None	9	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	548	10	1	10	1.8	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(Cc5ccccc5)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32388	109816	0	None	9	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	548	10	1	10	1.8	CCCn1c(=O)c2nc(-c3cc(OCC(=O)N4CCN(Cc5ccccc5)CC4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	11122708	119696	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 68-105Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 68-105	ChEMBL	422	4	2	8	4.1	CCn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL352073	119696	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 68-105Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 68-105	ChEMBL	422	4	2	8	4.1	CCn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	16071781	57705	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	351	4	1	5	3.6	O=C(Nc1cnc(-c2ccncc2Cl)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	CHEMBL1672628	57705	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assayDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay	ChEMBL	351	4	1	5	3.6	O=C(Nc1cnc(-c2ccncc2Cl)c(-c2cccnc2)n1)C1CC1	10.1021/ml100249e
	45268921	194431	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	317	6	2	6	0.9	CCn1c(=O)c2[nH]c(-c3ccc[nH]3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL560967	194431	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	317	6	2	6	0.9	CCn1c(=O)c2[nH]c(-c3ccc[nH]3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	127034214	138438	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	287	3	1	6	2.7	CC1=C(C(=O)OC(C)C)C(c2ccco2)n2ccnc2N1	10.1021/acs.jmedchem.5b01586
	CHEMBL3785381	138438	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	287	3	1	6	2.7	CC1=C(C(=O)OC(C)C)C(c2ccco2)n2ccnc2N1	10.1021/acs.jmedchem.5b01586
	12654835	56448	2	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	265	2	1	3	3.0	O=C(Nc1ccccc1)c1coc2ccccc2c1=O	10.1016/j.ejmech.2012.05.033
	CHEMBL1643120	56448	2	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation countingDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting	ChEMBL	265	2	1	3	3.0	O=C(Nc1ccccc1)c1coc2ccccc2c1=O	10.1016/j.ejmech.2012.05.033
	127043668	140627	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	524	11	0	10	2.3	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN3CCOCC3)cc2)n(CCC)c1=O	10.1016/j.bmc.2016.07.028
	CHEMBL3827920	140627	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranesDisplacement of [3H]PSB-603 from recombinant human adenosine receptor A2b expressed in CHO cell membranes	ChEMBL	524	11	0	10	2.3	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCCN3CCOCC3)cc2)n(CCC)c1=O	10.1016/j.bmc.2016.07.028
	45267987	193111	0	None	-112	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	294	4	2	5	2.2	Nc1nc(C(=O)NCc2ccccc2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL538629	193111	0	None	-112	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	294	4	2	5	2.2	Nc1nc(C(=O)NCc2ccccc2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	44442019	153768	0	None	-269	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	618	8	6	11	3.5	CC(C)(C)c1cc(C(=O)NCCc2ccc(Nc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)cc(C(C)(C)C)c1O	10.1016/j.bmcl.2007.07.035
	CHEMBL398669	153768	0	None	-269	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	618	8	6	11	3.5	CC(C)(C)c1cc(C(=O)NCCc2ccc(Nc3ncnc4c3ncn4[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)cc2)cc(C(C)(C)C)c1O	10.1016/j.bmcl.2007.07.035
	135448286	109210	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	507	10	2	10	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C(C)=O)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32288	109210	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	507	10	2	10	2.3	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(C(C)=O)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135522390	118623	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	550	10	2	11	2.0	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(N5CCOCC5)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL34281	118623	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	550	10	2	11	2.0	CCCn1c(=O)c2nc(-c3cc(OCC(=O)Nc4ccc(N5CCOCC5)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	145993331	166355	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	576	14	1	11	2.4	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCn3ccnc3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	CHEMBL4286634	166355	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	576	14	1	11	2.4	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCCn3ccnc3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	9860013	156429	0	None	-616	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	261	2	0	5	3.9	CC(C)c1nc(-c2nccs2)c2sccc2n1	10.1016/j.bmcl.2008.03.076
	CHEMBL407307	156429	0	None	-616	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	261	2	0	5	3.9	CC(C)c1nc(-c2nccs2)c2sccc2n1	10.1016/j.bmcl.2008.03.076
	9860013	156429	0	None	-616	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	261	2	0	5	3.9	CC(C)c1nc(-c2nccs2)c2sccc2n1	10.1021/jm4011669
	CHEMBL407307	156429	0	None	-616	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	ChEMBL	261	2	0	5	3.9	CC(C)c1nc(-c2nccs2)c2sccc2n1	10.1021/jm4011669
	11037739	164981	0	None	-6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 76-98Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 76-98	ChEMBL	450	6	2	8	4.8	CCCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL424161	164981	0	None	-6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 76-98Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 76-98	ChEMBL	450	6	2	8	4.8	CCCCn1cc2c(nc(NC(=O)Nc3ccc(Cl)cc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	136042348	70817	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	508	9	2	10	2.5	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc5c(c4)OCO5)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955926	70817	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	508	9	2	10	2.5	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc5c(c4)OCO5)nn3C)cc2n(CCC)c1=O	10.1021/jm201292w
	44308015	102891	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	266	3	0	8	-1.0	CC(=O)OCCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1021/jm0104318
	CHEMBL308464	102891	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	266	3	0	8	-1.0	CC(=O)OCCn1c(=O)c2c(ncn2C)n(C)c1=O	10.1021/jm0104318
	135546648	109213	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	467	8	2	8	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32289	109213	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	467	8	2	8	2.4	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(F)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	11728808	119794	0	None	-15	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 67-115Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 67-115	ChEMBL	388	4	2	8	3.4	CCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL352796	119794	0	None	-15	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 67-115Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 67-115	ChEMBL	388	4	2	8	3.4	CCn1cc2c(nc(NC(=O)Nc3ccccc3)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	136042330	70797	0	None	52	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	506	9	3	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(=O)O)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955905	70797	0	None	52	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	506	9	3	10	2.3	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5cc(C(=O)O)ccc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	21874782	176222	0	None	-38	4	Human	7.1	pKi	=	7.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	298	3	1	8	2.2	Nc1nc(-c2ccco2)c2nnn(Cc3cccs3)c2n1	10.1021/jm800961g
	CHEMBL460799	176222	0	None	-38	4	Human	7.1	pKi	=	7.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	298	3	1	8	2.2	Nc1nc(-c2ccco2)c2nnn(Cc3cccs3)c2n1	10.1021/jm800961g
	377	2707	47	None	-1479	15	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2006.01.110
	425	2707	47	None	-1479	15	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2006.01.110
	448222	2707	47	None	-1479	15	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2006.01.110
	CHEMBL464859	2707	47	None	-1479	15	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1016/j.bmcl.2006.01.110
	10267860	176239	0	None	-12	4	Human	6.1	pKi	=	6.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	317	3	1	8	2.0	N#Cc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	CHEMBL461007	176239	0	None	-12	4	Human	6.1	pKi	=	6.1	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	317	3	1	8	2.0	N#Cc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	2748301	171711	8	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	312	4	2	4	2.7	CC1=C(C(=O)OCc2ccccc2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4474844	171711	8	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	312	4	2	4	2.7	CC1=C(C(=O)OCc2ccccc2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	44588436	174126	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	341	5	2	5	3.0	CCCn1c(=O)c2[nH]c(-c3ccc(C)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	CHEMBL455985	174126	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human cloned adenosine A2B receptor expressed in HEK293 cells	ChEMBL	341	5	2	5	3.0	CCCn1c(=O)c2[nH]c(-c3ccc(C)cc3)c(O)c2n(CCC)c1=O	10.1016/j.bmc.2008.09.067
	46227950	198213	0	None	4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	5	1	6	2.0	C#CCn1c(=O)c2[nH]c(Cc3c(F)cccc3F)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL594728	198213	0	None	4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	396	5	1	6	2.0	C#CCn1c(=O)c2[nH]c(Cc3c(F)cccc3F)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	46227995	199749	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	430	8	0	9	2.9	CCSCCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL604885	199749	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	430	8	0	9	2.9	CCSCCn1c(=O)c2c(nc(Cc3cccs3)n2C)n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	44450875	96369	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	502	6	1	7	3.0	COc1cc(OCC(=O)N2CCC(c3ccccc3)CC2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	CHEMBL265182	96369	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	502	6	1	7	3.0	COc1cc(OCC(=O)N2CCC(c3ccccc3)CC2)ccc1-c1cc2c([nH]1)c(=O)n(C)c(=O)n2C	10.1016/j.bmc.2008.01.002
	44410406	75193	0	None	-6760	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	472	6	5	10	0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)C4CCCCC4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	CHEMBL204526	75193	0	None	-6760	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsDisplacement of [125I]ABOPX from human adenosine A2B receptor in HEK cells	ChEMBL	472	6	5	10	0.3	CCNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC)nc(C#CC(O)C4CCCCC4)nc32)[C@H](O)[C@@H]1O	10.1016/j.bmcl.2006.01.110
	11198201	110175	6	None	3	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	327	5	2	6	2.0	CCCn1c(=O)c2nc(-c3ccc(N)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL32598	110175	6	None	3	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	327	5	2	6	2.0	CCCn1c(=O)c2nc(-c3ccc(N)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	66894327	155421	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	559	9	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(OC(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4061490	155421	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	559	9	1	9	3.5	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5cccc(OC(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	66894035	155650	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	505	9	1	9	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(OC)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4064289	155650	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	505	9	1	9	2.6	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(OC)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	66894143	157884	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	519	9	1	7	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5cccc(F)c5)C4)cc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4090483	157884	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	519	9	1	7	3.9	CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5cccc(F)c5)C4)cc3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	9839378	139588	0	None	2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	302	5	2	6	1.1	CCCn1c(=O)c2nc(-c3cn[nH]c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	CHEMBL380176	139588	0	None	2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	302	5	2	6	1.1	CCCn1c(=O)c2nc(-c3cn[nH]c3)[nH]c2n(CCC)c1=O	10.1021/jm051268+
	10852506	106485	0	None	-11	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 7.4-11.3Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 7.4-11.3	ChEMBL	311	4	1	8	2.4	CC(C)CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL315150	106485	0	None	-11	6	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 7.4-11.3Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 7.4-11.3	ChEMBL	311	4	1	8	2.4	CC(C)CCn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	44219684	194085	0	None	12	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	502	10	2	9	2.5	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL557694	194085	0	None	12	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	502	10	2	9	2.5	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	44450955	166824	0	None	43	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	530	8	1	7	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccc(OC)cc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	CHEMBL429512	166824	0	None	43	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	530	8	1	7	3.9	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccc(OC)cc5)CC4)cc3)cc21	10.1016/j.bmc.2008.01.002
	10204847	74062	0	None	23	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	460	9	2	6	4.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL202665	74062	0	None	23	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	460	9	2	6	4.0	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	136002248	70799	0	None	269	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	564	8	2	9	4.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(Cl)cc(C(F)(F)F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	CHEMBL1955907	70799	0	None	269	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation countingDisplacement of [3H]MRE2029-F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells after 120 mins by scintillation counting	ChEMBL	564	8	2	9	4.2	CCCn1c(=O)c2[nH]c(-c3cc(OCc4nc5c(Cl)cc(C(F)(F)F)cc5[nH]4)nn3C)nc2n(CCC)c1=O	10.1021/jm201292w
	44574118	178218	0	None	1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	422	4	2	6	3.1	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	CHEMBL469119	178218	0	None	1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counterDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter	ChEMBL	422	4	2	6	3.1	Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccc(F)cc4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2009.03.062
	11612118	140145	0	None	11	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	450	7	2	6	3.3	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc21	10.1021/jm0506221
	CHEMBL381538	140145	0	None	11	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	450	7	2	6	3.3	CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)cc21	10.1021/jm0506221
	44450826	95419	0	None	25	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	524	8	1	6	3.9	O=C(COc1ccc(-c2cc3c([nH]2)c(=O)n(CC2CC2)c(=O)n3CC2CC2)cc1)N1CCc2ccccc2C1	10.1016/j.bmc.2008.01.002
	CHEMBL259104	95419	0	None	25	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	524	8	1	6	3.9	O=C(COc1ccc(-c2cc3c([nH]2)c(=O)n(CC2CC2)c(=O)n3CC2CC2)cc1)N1CCc2ccccc2C1	10.1016/j.bmc.2008.01.002
	44451253	95556	0	None	33	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	491	5	1	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259733	95556	0	None	33	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	491	5	1	7	2.1	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	44450958	95592	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	548	6	1	6	4.2	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	CHEMBL259931	95592	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	548	6	1	6	4.2	Cn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)(c5ccccc5)CC4)cc3)cc2n(C)c1=O	10.1016/j.bmc.2008.01.002
	66893166	156410	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	493	8	1	8	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4072877	156410	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	493	8	1	8	2.8	CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(F)cc5)C4)c3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	11656075	71949	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	488	10	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OC(CC)C(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL198338	71949	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	488	10	2	6	4.8	CCCn1c(=O)c2[nH]c(-c3ccc(OC(CC)C(=O)Nc4ccccc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	2690	888	59	None	-30	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	384	888	59	None	-30	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	CHEMBL16687	888	59	None	-30	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cells	ChEMBL	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10.1021/jm900413e
	57429610	158291	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	486	6	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(OC(F)(F)F)cc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	CHEMBL4094840	158291	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 minsDisplacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins	ChEMBL	486	6	1	8	3.1	CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(OC(F)(F)F)cc4)c3)nc2n(CC)c1=O	10.1016/j.ejmech.2017.04.014
	135499926	99448	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	623	11	2	9	4.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5cccc(C(F)(F)F)c5)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL286212	99448	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	623	11	2	9	4.9	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4ccc(OCc5cccc(C(F)(F)F)c5)cc4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	135465778	99924	0	None	22	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	480	8	3	9	2.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)Nc4cccc(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL290105	99924	0	None	22	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	480	8	3	9	2.8	CCCn1c(=O)c2nc(-c3cc(NC(=O)Nc4cccc(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	216466	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1016/j.bmc.2010.01.072
	5605	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1016/j.bmc.2010.01.072
	CHEMBL386974	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1016/j.bmc.2010.01.072
	CHEMBL414157	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1016/j.bmc.2010.01.072
	DB12569	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1016/j.bmc.2010.01.072
	216466	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm060539t
	5605	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm060539t
	CHEMBL386974	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm060539t
	CHEMBL414157	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm060539t
	DB12569	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptorDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm060539t
	216466	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm0605381
	5605	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm0605381
	CHEMBL386974	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm0605381
	CHEMBL414157	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm0605381
	DB12569	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cellsDisplacement of [125I]3-(4-aminobenzyl)-8-phenyloxyacetate-1-propyl-xanthine from human adenosine A2B receptor expressed in HEK cells	ChEMBL	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	10.1021/jm0605381
	136414898	156872	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	510	9	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5cccc(F)c5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	CHEMBL4078707	156872	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodDisplacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting method	ChEMBL	510	9	1	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC4CC(=O)N(c5cccc(F)c5)C4)no3)nc2n(CCC)c1=O	10.1016/j.ejmech.2016.11.007
	10696675	28668	0	None	1	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 81-101Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 81-101	ChEMBL	498	6	2	8	5.3	O=C(Nc1cccc(Cl)c1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	CHEMBL137950	28668	0	None	1	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 81-101Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 81-101	ChEMBL	498	6	2	8	5.3	O=C(Nc1cccc(Cl)c1)Nc1nc2nn(CCc3ccccc3)cc2c2nc(-c3ccco3)nn12	10.1021/jm001047y
	10587109	118267	0	None	-31	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 81-101Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 81-101	ChEMBL	255	1	1	8	0.9	Cn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	CHEMBL342059	118267	0	None	-31	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 81-101Displacement of [3H]DPCPX from Adenosine A2b receptor expressed in CHO cells; range 81-101	ChEMBL	255	1	1	8	0.9	Cn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1021/jm001047y
	10587109	118267	0	None	-31	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in CHO cells by scintillation counterDisplacement of [3H]DPCPX from human A2B receptor expressed in CHO cells by scintillation counter	ChEMBL	255	1	1	8	0.9	Cn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1016/j.ejmech.2015.12.019
	CHEMBL342059	118267	0	None	-31	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]DPCPX from human A2B receptor expressed in CHO cells by scintillation counterDisplacement of [3H]DPCPX from human A2B receptor expressed in CHO cells by scintillation counter	ChEMBL	255	1	1	8	0.9	Cn1cc2c(nc(N)n3nc(-c4ccco4)nc23)n1	10.1016/j.ejmech.2015.12.019
	24827594	157265	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	274	3	2	5	1.2	CCOC(=O)C1=C(C)N/C(=N\C#N)NC1c1ccco1	10.1021/acs.jmedchem.7b00138
	CHEMBL4083334	157265	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	274	3	2	5	1.2	CCOC(=O)C1=C(C)N/C(=N\C#N)NC1c1ccco1	10.1021/acs.jmedchem.7b00138
	2153	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2016.11.007
	2620	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2016.11.007
	413	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2016.11.007
	CHEMBL190	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2016.11.007
	DB00277	3728	108	None	-21	14	Human	5.1	pKi	=	5.1	Binding	Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assayDisplacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2016.11.007
	162666447	181696	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	259	2	2	4	2.4	CC1=C(c2ncc(C)o2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4783984	181696	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	259	2	2	4	2.4	CC1=C(c2ncc(C)o2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	9968253	189585	0	None	-223	4	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	350	4	1	9	1.9	COC(=O)c1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	CHEMBL517429	189585	0	None	-223	4	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	350	4	1	9	1.9	COC(=O)c1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	2153	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	2620	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	413	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	CHEMBL190	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	DB00277	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm0104318
	2153	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	2153	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2013.09.044
	2620	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	2620	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2013.09.044
	413	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	413	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2013.09.044
	CHEMBL190	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	CHEMBL190	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2013.09.044
	DB00277	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2010.01.072
	DB00277	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptorBinding affinity to human adenosine A2B receptor	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.bmc.2013.09.044
	2153	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1039/C8MD00070K
	2620	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1039/C8MD00070K
	413	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1039/C8MD00070K
	CHEMBL190	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1039/C8MD00070K
	DB00277	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human adenosine A2B receptor by radioligand displacement assayBinding affinity to human adenosine A2B receptor by radioligand displacement assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1039/C8MD00070K
	2153	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/acs.jmedchem.5b01586
	2620	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/acs.jmedchem.5b01586
	413	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/acs.jmedchem.5b01586
	CHEMBL190	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/acs.jmedchem.5b01586
	DB00277	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrsDisplacement of [125I]-ABOPX from human recombinant Adenosine A2B receptor expressed in HEK293 cells after 3 hrs	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/acs.jmedchem.5b01586
	2153	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2019.111879
	2620	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2019.111879
	413	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2019.111879
	CHEMBL190	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2019.111879
	DB00277	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assayDisplacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1016/j.ejmech.2019.111879
	2153	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm051268+
	2620	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm051268+
	413	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm051268+
	CHEMBL190	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm051268+
	DB00277	3728	108	None	-21	14	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	10.1021/jm051268+
	44390523	63470	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(C)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL180236	63470	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	500	9	1	9	4.3	CCCn1c(=O)c2nc(-c3ccc(OCc4noc(-c5ccc(C)cc5)n4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	11584408	73016	0	None	7	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	518	10	2	6	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc([N+](C)(C)C)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	CHEMBL201447	73016	0	None	7	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant human adenosine A2B receptorBinding affinity to recombinant human adenosine A2B receptor	ChEMBL	518	10	2	6	4.2	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc([N+](C)(C)C)cc4)cc3)cc2n(CCC)c1=O	10.1021/jm0506221
	25066016	95729	2	None	-275	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	259	2	0	5	3.7	c1csc(-c2nc(C3CC3)nc3ccsc23)n1	10.1016/j.bmcl.2008.03.076
	CHEMBL260719	95729	2	None	-275	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human adenosine A2B receptorBinding affinity at human adenosine A2B receptor	ChEMBL	259	2	0	5	3.7	c1csc(-c2nc(C3CC3)nc3ccsc23)n1	10.1016/j.bmcl.2008.03.076
	145993147	166396	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	581	13	1	11	1.5	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN3CCOCC3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	CHEMBL4287298	166396	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranesDisplacement of [3H]PSB-602 from human adenosine A2B receptor expressed in CHO cell membranes	ChEMBL	581	13	1	11	1.5	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccc(OCC(=O)NCCN3CCOCC3)cc2)n(CCC)c1=O	10.1039/C8MD00070K
	21874722	176236	0	None	-3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	321	4	2	8	1.6	NCc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	CHEMBL460976	176236	0	None	-3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	321	4	2	8	1.6	NCc1ccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)cc1	10.1021/jm800961g
	11392671	193610	0	None	-416	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	308	4	2	5	2.6	Cc1ccccc1CNC(=O)c1cc(-c2ccco2)nc(N)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL551368	193610	0	None	-416	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	308	4	2	5	2.6	Cc1ccccc1CNC(=O)c1cc(-c2ccco2)nc(N)n1	10.1016/j.bmcl.2009.03.142
	156020727	177522	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	2	6	2.6	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cn[nH]c1	10.1021/acs.jmedchem.0c00564
	CHEMBL4647965	177522	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	323	3	2	6	2.6	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1cn[nH]c1	10.1021/acs.jmedchem.0c00564
	45270541	193520	0	None	-194	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	312	4	2	5	2.4	Nc1nc(C(=O)NCc2cccc(F)c2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	CHEMBL550636	193520	0	None	-194	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to adenosine A2B receptorBinding affinity to adenosine A2B receptor	ChEMBL	312	4	2	5	2.4	Nc1nc(C(=O)NCc2cccc(F)c2)cc(-c2ccco2)n1	10.1016/j.bmcl.2009.03.142
	135483531	78117	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	543	9	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc(Br)cc4)n(C)n3)nc2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL2112067	78117	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	543	9	2	9	2.9	CCCn1c(=O)c2[nH]c(-c3cc(OCC(=O)Nc4ccc(Br)cc4)n(C)n3)nc2n(CCC)c1=O	10.1021/jm0309654
	45270544	193521	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	517	10	3	9	2.5	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4nc5ccccc5[nH]4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	CHEMBL550638	193521	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human adenosine A2b receptor expressed in HEK293 cellsBinding affinity to human adenosine A2b receptor expressed in HEK293 cells	ChEMBL	517	10	3	9	2.5	CCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4nc5ccccc5[nH]4)cc3)nc2n(CCCOC)c1=O	10.1016/j.bmc.2009.03.029
	46227957	199675	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	402	7	1	8	2.5	CSCCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	CHEMBL604492	199675	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cellsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells	ChEMBL	402	7	1	8	2.5	CSCCn1c(=O)c2[nH]c(Cc3cccs3)nc2n(Cc2ccco2)c1=O	10.1016/j.bmc.2009.07.034
	44316058	203816	0	None	-104	3	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	CHEMBL80974	203816	0	None	-104	3	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
	21874520	176223	0	None	-42	4	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	391	5	1	8	2.6	CC(C)N(C)C(=O)c1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	CHEMBL460805	176223	0	None	-42	4	Human	6.0	pKi	=	6.0	Binding	Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingDisplacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation counting	ChEMBL	391	5	1	8	2.6	CC(C)N(C)C(=O)c1cccc(Cn2nnc3c(-c4ccco4)nc(N)nc32)c1	10.1021/jm800961g
	44390571	63960	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5cccc(C(F)(F)F)c5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	CHEMBL181067	63960	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cellsBinding affinity for adenosine A2b receptor by using as [3H]ZM-241385 (14 nM) radioligand in membranes from HEK-A2B cells	ChEMBL	554	9	1	9	5.0	CCCn1c(=O)c2nc(-c3ccc(OCc4nc(-c5cccc(C(F)(F)F)c5)no4)cc3)[nH]c2n(CCC)c1=O	10.1016/j.bmcl.2004.11.044
	101422	91101	15	None	-2	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	218	1	0	6	-0.9	C#CCn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	CHEMBL24049	91101	15	None	-2	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	218	1	0	6	-0.9	C#CCn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	9794423	101695	1	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	218	1	0	6	-0.9	C#CCn1c(=O)n(C)c(=O)c2c1ncn2C	10.1021/jm0104318
	CHEMBL302725	101695	1	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	218	1	0	6	-0.9	C#CCn1c(=O)n(C)c(=O)c2c1ncn2C	10.1021/jm0104318
	101446	91867	27	None	1	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	220	2	0	6	-0.4	C=CCn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	CHEMBL24289	91867	27	None	1	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	220	2	0	6	-0.4	C=CCn1cnc2c1c(=O)n(C)c(=O)n2C	10.1021/jm0104318
	44281663	167467	0	None	18	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	505	10	2	8	3.6	CCCn1c(=O)c2nc(-c3ccc(NC(=O)Cc4ccc(OC)c(OC)c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL432273	167467	0	None	18	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	505	10	2	8	3.6	CCCn1c(=O)c2nc(-c3ccc(NC(=O)Cc4ccc(OC)c(OC)c4)cc3)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	162669067	182169	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	276	3	2	4	2.0	CC1=C(C(=O)OC2CCC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	CHEMBL4790210	182169	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	276	3	2	4	2.0	CC1=C(C(=O)OC2CCC2)C(c2ccco2)NC(=O)N1	10.1021/acs.jmedchem.0c01431
	168288152	191224	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	394	6	1	7	2.0	CCCn1c(=O)c2[nH]c(-c3cccc(S(=O)(=O)F)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	CHEMBL5198830	191224	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assayDisplacement of [3H]PSB-603 from human adenosine A2B receptor expressed in CHO cell membrane and measured after 0.5 hrs by radioligand displacement assay	ChEMBL	394	6	1	7	2.0	CCCn1c(=O)c2[nH]c(-c3cccc(S(=O)(=O)F)c3)nc2n(CCC)c1=O	10.1039/d2md00132b
	135522363	170005	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	479	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	CHEMBL445056	170005	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsBinding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells	ChEMBL	479	9	2	9	2.3	CCCn1c(=O)c2nc(-c3cc(NC(=O)Cc4cccc(OC)c4)nn3C)[nH]c2n(CCC)c1=O	10.1021/jm0309654
	137649307	156731	0	None	-6	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	348	5	1	4	4.4	COc1cccc(-c2cc(NC(C)=O)nc(-c3cccc(OC)c3)c2)c1	10.1021/acs.jmedchem.7b00860
	CHEMBL4076880	156731	0	None	-6	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 minsDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins	ChEMBL	348	5	1	4	4.4	COc1cccc(-c2cc(NC(C)=O)nc(-c3cccc(OC)c3)c2)c1	10.1021/acs.jmedchem.7b00860
	163215620	189739	0	None	-398	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	318	3	2	6	1.8	Nc1nc(C(=O)NCc2ccccn2)cn2c1nc1ccccc12	10.1021/acs.jmedchem.2c00101
	CHEMBL5176737	189739	0	None	-398	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	318	3	2	6	1.8	Nc1nc(C(=O)NCc2ccccn2)cn2c1nc1ccccc12	10.1021/acs.jmedchem.2c00101
	CHEMBL5203105	189739	0	None	-398	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting methodDisplacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method	ChEMBL	318	3	2	6	1.8	Nc1nc(C(=O)NCc2ccccn2)cn2c1nc1ccccc12	10.1021/acs.jmedchem.2c00101
	155542720	172582	0	None	11	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	552	8	3	8	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(=O)O)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	CHEMBL4521715	172582	0	None	11	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting methodDisplacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method	ChEMBL	552	8	3	8	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(=O)O)cc5)CC4)cc3)[nH]c2c1=O	10.1021/acs.jmedchem.9b00071
	10998551	101634	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	220	1	2	4	0.5	O=c1[nH]c2[nH]cnc2c(=O)n1C1CCCC1	10.1021/jm0104318
	CHEMBL302344	101634	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	220	1	2	4	0.5	O=c1[nH]c2[nH]cnc2c(=O)n1C1CCCC1	10.1021/jm0104318
	11004373	119733	0	None	-10	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 67-141Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 67-141	ChEMBL	422	4	2	8	4.1	CCn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	CHEMBL352345	119733	0	None	-10	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 67-141Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 67-141	ChEMBL	422	4	2	8	4.1	CCn1cc2c(nc(NC(=O)Nc3ccccc3Cl)n3nc(-c4ccco4)nc23)n1	10.1021/jm0109614
	46837841	10510	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	514	8	0	7	4.0	CCCn1c(=O)c2c(cc(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)n2C)n(CCC)c1=O	10.1016/j.ejmech.2010.03.011
	CHEMBL1170168	10510	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 minsDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells after 30 mins	ChEMBL	514	8	0	7	4.0	CCCn1c(=O)c2c(cc(-c3ccc(OCC(=O)N4CCc5ccccc5C4)cc3)n2C)n(CCC)c1=O	10.1016/j.ejmech.2010.03.011
	56627882	117994	0	None	-194	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	367	3	3	12	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1039/C5MD00086F
	CHEMBL3414937	117994	0	None	-194	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	367	3	3	12	-0.9	CCn1nnc([C@H]2O[C@@H](n3cnc4c(N)nc(Cl)nc43)[C@H](O)[C@@H]2O)n1	10.1039/C5MD00086F
	681	1432	65	None	-15	39	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	940	1432	65	None	-15	39	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	947	1432	65	None	-15	39	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	CHEMBL59	1432	65	None	-15	39	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	DB00988	1432	65	None	-15	39	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for its binding affinity against Alpha-2 adrenergic receptorCompound was tested for its binding affinity against Alpha-2 adrenergic receptor	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
	156018247	177196	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	340	3	1	7	3.3	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccns1	10.1021/acs.jmedchem.0c00564
	CHEMBL4643113	177196	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting methodDisplacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method	ChEMBL	340	3	1	7	3.3	CCOC(=O)C1=C(C)Nc2nc3ccccc3n2C1c1ccns1	10.1021/acs.jmedchem.0c00564
	11524593	140734	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	420	9	1	7	3.4	CCCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2n(CCCC)c1=O	10.1021/jm051268+
	CHEMBL383201	140734	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	420	9	1	7	3.4	CCCCn1c(=O)c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2n(CCCC)c1=O	10.1021/jm051268+
	3123319	28490	7	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	252	2	2	5	1.7	COC(=O)C1=C(C)N=C(S)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	CHEMBL1377918	28490	7	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	252	2	2	5	1.7	COC(=O)C1=C(C)N=C(S)NC1c1ccco1	10.1021/acs.jmedchem.0c01431
	19818540	75044	0	None	-5	2	Human	5.0	pKi	=	5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	354	6	1	5	3.3	CC(C)CCn1c(=O)c2nc(-c3ccccc3)[nH]c2n(CC(C)C)c1=O	10.1021/jm0104318
	CHEMBL20402	75044	0	None	-5	2	Human	5.0	pKi	=	5	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	ChEMBL	354	6	1	5	3.3	CC(C)CCn1c(=O)c2nc(-c3ccccc3)[nH]c2n(CC(C)C)c1=O	10.1021/jm0104318
	11655061	138630	0	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	438	7	1	7	3.2	CC(C)Cn1c(=O)c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2n(CC(C)C)c1=O	10.1021/jm051268+
	CHEMBL378743	138630	0	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cellsDisplacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells	ChEMBL	438	7	1	7	3.2	CC(C)Cn1c(=O)c2nc(-c3cnn(Cc4cccc(F)c4)c3)[nH]c2n(CC(C)C)c1=O	10.1021/jm051268+
	CHEMBL5079363	212833	0	None	-457	4	Human	5.0	pKi	=	5	Binding	Displacement of [3H] DPCPX from human recombinant A2B adenosine receptor expressed in HEK293 cells incubated for 30 mins by radioligand binding competition assayDisplacement of [3H] DPCPX from human recombinant A2B adenosine receptor expressed in HEK293 cells incubated for 30 mins by radioligand binding competition assay	ChEMBL		None	None	None		Cc1cnc(-c2nc3c(-c4ccc(=O)n(C)c4)cnc(N)n3n2)s1	10.1021/acsmedchemlett.1c00599
	3284	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	44185871	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	5728	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	CHEMBL483688	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	3284	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	44185871	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	5728	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	CHEMBL483688	3155	28	None	-1	7	Human	9.4	pKd	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	3284	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	44185871	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	5728	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	CHEMBL483688	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	3284	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	44185871	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	5728	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	CHEMBL483688	3155	28	None	1	7	Mouse	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	449	2595	44	None	-1	9	Human	9.8	pKd	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	11266650
	453	2595	44	None	-1	9	Human	9.8	pKd	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	11266650
	6603931	2595	44	None	-1	9	Human	9.8	pKd	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	11266650
	CHEMBL273807	2595	44	None	-1	9	Human	9.8	pKd	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	11266650
	450	2911	8	None	257	4	Human	9.8	pKd	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	15194002
	454	2911	8	None	257	4	Human	9.8	pKd	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	15194002
	5311041	2911	8	None	257	4	Human	9.8	pKd	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	15194002
	CHEMBL485862	2911	8	None	257	4	Human	9.8	pKd	None	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	15194002
	44186666	185066	0	UNDEFINED	144	5	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL486478	185066	0	UNDEFINED	144	5	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	None
	44186580	183614	0	UNDEFINED	30	6	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	528	6	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL483261	183614	0	UNDEFINED	30	6	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	528	6	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	None
	44186668	190904	0	UNDEFINED	245	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL519390	190904	0	UNDEFINED	245	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	562	6	2	7	2.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	None
	44186667	185067	0	UNDEFINED	478	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL486479	185067	0	UNDEFINED	478	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O	None
	44186581	3144	23	UNDEFINED	851	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	None
	6561	3144	23	UNDEFINED	851	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	None
	CHEMBL482436	3144	23	UNDEFINED	851	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	None
	450	2911	8	UNDEFINED	257	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	None
	454	2911	8	UNDEFINED	257	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	None
	5311041	2911	8	UNDEFINED	257	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	None
	CHEMBL485862	2911	8	UNDEFINED	257	4	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	None
	44185870	183638	0	UNDEFINED	117	5	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	514	5	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL483487	183638	0	UNDEFINED	117	5	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	514	5	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	None
	44186626	184016	0	UNDEFINED	245	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL484900	184016	0	UNDEFINED	245	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	None
	44185872	190794	0	UNDEFINED	416	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	524	5	2	7	1.9	C#CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL519253	190794	0	UNDEFINED	416	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	524	5	2	7	1.9	C#CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O	None
	3284	3155	28	UNDEFINED	-1	7	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	None
	44185871	3155	28	UNDEFINED	-1	7	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	None
	5728	3155	28	UNDEFINED	-1	7	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	None
	CHEMBL483688	3155	28	UNDEFINED	-1	7	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	None
	44186624	191828	0	UNDEFINED	57	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL520830	191828	0	UNDEFINED	57	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	526	7	2	7	2.1	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	None
	44186582	183521	0	UNDEFINED	158	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	528	6	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL482638	183521	0	UNDEFINED	158	4	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	528	6	2	7	2.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	None
	44186625	184015	0	UNDEFINED	208	6	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	512	6	2	7	1.7	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL484899	184015	0	UNDEFINED	208	6	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	512	6	2	7	1.7	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O	None
	44186669	185205	0	UNDEFINED	354	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL486688	185205	0	UNDEFINED	354	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	576	7	2	7	3.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O	None
	44186622	183637	0	UNDEFINED	208	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	542	7	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL483469	183637	0	UNDEFINED	208	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	542	7	2	7	2.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O	None
	44186715	190615	0	UNDEFINED	54	4	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	522	7	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL518972	190615	0	UNDEFINED	54	4	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	522	7	2	7	2.3	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	None
	44186718	183581	0	UNDEFINED	117	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	538	6	2	9	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	None
	CHEMBL483065	183581	0	UNDEFINED	117	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	538	6	2	9	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	None
	44186717	183553	0	UNDEFINED	89	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	538	8	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL482855	183553	0	UNDEFINED	89	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	538	8	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	None
	44186719	185324	0	UNDEFINED	74	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	552	7	2	9	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	None
	CHEMBL486893	185324	0	UNDEFINED	74	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	552	7	2	9	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O	None
	44186579	191178	0	UNDEFINED	131	6	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	494	6	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL519813	191178	0	UNDEFINED	131	6	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	494	6	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	44186716	183522	0	UNDEFINED	194	6	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	524	7	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL482648	183522	0	UNDEFINED	194	6	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	524	7	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	None
	44583036	186362	0	UNDEFINED	7	5	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	None
	CHEMBL490262	186362	0	UNDEFINED	7	5	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	None
	CHEMBL521280	186362	0	UNDEFINED	7	5	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	400	8	3	7	0.6	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O	None
	44186623	191481	0	UNDEFINED	31	6	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	512	6	2	7	1.7	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL520297	191481	0	UNDEFINED	31	6	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	512	6	2	7	1.7	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O	None
	11605883	79527	5	UNDEFINED	42	6	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL212625	79527	5	UNDEFINED	42	6	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	44186670	191694	0	UNDEFINED	24	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	508	6	2	7	1.9	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL520617	191694	0	UNDEFINED	24	4	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	508	6	2	7	1.9	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O	None
	None	215386	0	UNDEFINED	208	4	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	485	9	2	7	3.9	CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=C2)C3=CC=C(C=C3)OCC(=O)NC4=CC=C(C=C4)C#N	None
	44185874	185068	0	UNDEFINED	20	5	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	524	7	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL486481	185068	0	UNDEFINED	20	5	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	524	7	2	8	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	None
	982689	197553	9	UNDEFINED	-141	3	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	414	6	1	5	5.3	COc1ccc(C(=O)c2sc(NC(=O)c3ccccc3)nc2-c2ccccc2)cc1	None
	CHEMBL590033	197553	9	UNDEFINED	-141	3	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	414	6	1	5	5.3	COc1ccc(C(=O)c2sc(NC(=O)c3ccccc3)nc2-c2ccccc2)cc1	None
	46229302	197593	0	UNDEFINED	-14	4	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	4.6	CCOC(=O)Nc1nc(-c2ccccc2)c(C(=O)c2ccc(OC)cc2)s1	None
	CHEMBL590301	197593	0	UNDEFINED	-14	4	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	4.6	CCOC(=O)Nc1nc(-c2ccccc2)c(C(=O)c2ccc(OC)cc2)s1	None
	5033052	197793	15	UNDEFINED	-173	6	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	374	5	1	5	4.9	O=C(Nc1nc(-c2ccccc2)c(C(=O)c2ccccc2)s1)c1ccco1	None
	CHEMBL591710	197793	15	UNDEFINED	-173	6	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	374	5	1	5	4.9	O=C(Nc1nc(-c2ccccc2)c(C(=O)c2ccccc2)s1)c1ccco1	None
	46228971	197912	0	UNDEFINED	-208	5	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	398	5	1	4	5.6	Cc1ccc(C(=O)c2sc(NC(=O)c3ccccc3)nc2-c2ccccc2)cc1	None
	CHEMBL592679	197912	0	UNDEFINED	-208	5	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	398	5	1	4	5.6	Cc1ccc(C(=O)c2sc(NC(=O)c3ccccc3)nc2-c2ccccc2)cc1	None
	981611	199048	17	UNDEFINED	-104	4	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	384	5	1	4	5.3	O=C(Nc1nc(-c2ccccc2)c(C(=O)c2ccccc2)s1)c1ccccc1	None
	CHEMBL600232	199048	17	UNDEFINED	-104	4	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	384	5	1	4	5.3	O=C(Nc1nc(-c2ccccc2)c(C(=O)c2ccccc2)s1)c1ccccc1	None
	7315332	199374	6	UNDEFINED	-2	3	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	386	5	1	5	5.3	CCOC(=O)Nc1nc(-c2ccccc2)c(C(=O)c2ccc(Cl)cc2)s1	None
	CHEMBL602722	199374	6	UNDEFINED	-2	3	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	386	5	1	5	5.3	CCOC(=O)Nc1nc(-c2ccccc2)c(C(=O)c2ccc(Cl)cc2)s1	None
	46228988	199407	0	UNDEFINED	-83	3	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	408	5	1	5	5.5	O=C(Nc1nc(-c2ccccc2)c(C(=O)c2ccc(Cl)cc2)s1)c1ccco1	None
	CHEMBL602950	199407	0	UNDEFINED	-83	3	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	408	5	1	5	5.5	O=C(Nc1nc(-c2ccccc2)c(C(=O)c2ccc(Cl)cc2)s1)c1ccco1	None
	None	215825	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	432	5	1	4	6.3	CC1=CC=C(C=C1)C(=O)NC2=NC(=C(S2)C(=O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4	None
	None	215826	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	398	5	1	4	5.6	CC1=CC=C(C=C1)C(=O)NC2=NC(=C(S2)C(=O)C3=CC=CC=C3)C4=CC=CC=C4	None
	None	215827	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	462	6	1	6	4.7	CS(=O)(=O)C1=CC=C(C=C1)C(=O)C2=C(N=C(S2)NC(=O)C3=CC=CC=C3)C4=CC=CC=C4	None
	None	215828	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	434	6	1	6	5.2	CS(=O)(=O)C1=CC=C(C=C1)C(=O)C2=C(N=C(S2)NC3=CC=CC=C3)C4=CC=CC=C4	None
	None	215829	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	370	5	1	4	6.1	CC1=CC=C(C=C1)C(=O)C2=C(N=C(S2)NC3=CC=CC=C3)C4=CC=CC=C4	None
	None	215830	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	386	6	1	5	5.8	COC1=CC=C(C=C1)C(=O)C2=C(N=C(S2)NC3=CC=CC=C3)C4=CC=CC=C4	None
	None	215831	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	328	4	1	4	4.7	CNC1=NC(=C(S1)C(=O)C2=CC=C(C=C2)Cl)C3=CC=CC=C3	None
	None	215832	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	1	5	4.1	CNC1=NC(=C(S1)C(=O)C2=CC=C(C=C2)OC)C3=CC=CC=C3	None
	None	215833	0	UNDEFINED	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	294	4	1	4	4.1	CNC1=NC(=C(S1)C(=O)C2=CC=CC=C2)C3=CC=CC=C3	None
	2519	765	83	UNDEFINED	-9	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	407	765	83	UNDEFINED	-9	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	463	765	83	UNDEFINED	-9	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	CHEMBL113	765	83	UNDEFINED	-9	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	DB00201	765	83	UNDEFINED	-9	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	380	1256	49	125I-ABOPX	-17782	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	None
	657378	1256	49	125I-ABOPX	-17782	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	None
	CHEMBL68738	1256	49	125I-ABOPX	-17782	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	None
	11081	3156	1	UNDEFINED	-30	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	None
	44437220	3156	1	UNDEFINED	-30	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	None
	CHEMBL239232	3156	1	UNDEFINED	-30	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	378	3	1	7	1.4	Cn1c(=O)n(C)c(=O)c2c1nc1n2CCCN1CCc1c[nH]c2c1cccc2	None
	44437219	90206	0	UNDEFINED	-1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	340	3	0	8	0.3	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccccn2)n(C)c1=O	None
	CHEMBL239018	90206	0	UNDEFINED	-1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	340	3	0	8	0.3	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccccn2)n(C)c1=O	None
	3162488	90699	10	UNDEFINED	-31	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	339	3	0	7	0.9	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2)n(C)c1=O	None
	CHEMBL239864	90699	10	UNDEFINED	-31	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	339	3	0	7	0.9	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2)n(C)c1=O	None
	11003653	145293	0	UNDEFINED	-2	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	389	4	0	8	1.4	Cn1c(=O)c2c(nc3n2CCCN3CCOc2ccc(Cl)cc2)n(C)c1=O	None
	CHEMBL391718	145293	0	UNDEFINED	-2	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	389	4	0	8	1.4	Cn1c(=O)c2c(nc3n2CCCN3CCOc2ccc(Cl)cc2)n(C)c1=O	None
	44437233	154382	0	UNDEFINED	-1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	368	5	1	8	0.4	Cn1c(=O)c2c(nc3n2CCCN3CCNCc2ccccc2)n(C)c1=O	None
	CHEMBL401028	154382	0	UNDEFINED	-1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	368	5	1	8	0.4	Cn1c(=O)c2c(nc3n2CCCN3CCNCc2ccccc2)n(C)c1=O	None
	3668	214342	0	125I-ABOPX	-9120	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	510	5	4	9	0.4	CNC(=O)C1C(C(C(O1)N2C=NC3=C2N=CN=C3NCC4=CC(=CC=C4)I)O)O	None
	None	214347	0	125I-ABOPX	-8511	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	6	4	9	0.5	CC(CC1=CC=CC=C1)NC2=NC=NC3=C2N=CN3C4C(C(C(O4)CO)O)O	None
	None	214530	0	125I-ABOPX	-660	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	499	10	6	11	-0.2	CCNC(=O)C1C(C(C(O1)N2C=NC3=C2N=C(N=C3N)NCCC4=CC=C(C=C4)CCC(=O)O)O)O	None
	235481	214532	0	125I-ABOPX	-1258	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	301	2	4	9	-1.3	C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2N)Cl	None
	235481	214532	0	UNDEFINED	-1258	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	301	2	4	9	-1.3	C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2N)Cl	None
	None	214533	0	125I-ABOPX	-	1	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	527	6	6	11	-0.1	C1=CC(=C(C=C1CCNC2=NC3=C(C(=N2)N)N=CN3C4C(C(C(O4)CO)O)O)I)N	None
	44583035	172162	0	UNDEFINED	7	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	593	5	1	10	3.4	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)nc2n(C)c1=O	None
	CHEMBL450826	172162	0	UNDEFINED	7	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	593	5	1	10	3.4	Cn1c(=O)c2[nH]c(-c3ccc(OC(C)(C)C(=O)N4CCN(c5nc6cc(Cl)ccc6s5)CC4)cc3)nc2n(C)c1=O	None
	44185873	191879	0	UNDEFINED	31	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	510	6	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL520899	191879	0	UNDEFINED	31	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	510	6	2	8	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O	None
	1328	1337	30	125I-ABOPX	-7	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	None
	445	1337	30	125I-ABOPX	-7	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	None
	CHEMBL11348	1337	30	125I-ABOPX	-7	4	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	None
	404	4023	30	3H-cAMP	-229	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	None
	432	4023	30	3H-cAMP	-229	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	None
	5697	4023	30	3H-cAMP	-229	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	None
	CHEMBL273094	4023	30	3H-cAMP	-229	11	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	None
	2690	888	59	UNDEFINED	-30	9	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	384	888	59	UNDEFINED	-30	9	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	CHEMBL16687	888	59	UNDEFINED	-30	9	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	377	2707	47	UNDEFINED	-1479	15	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	425	2707	47	UNDEFINED	-1479	15	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	448222	2707	47	UNDEFINED	-1479	15	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	CHEMBL464859	2707	47	UNDEFINED	-1479	15	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	44185935	184941	0	UNDEFINED	4	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	417	5	2	6	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCCCC4)cc3)[nH]c2c1=O	None
	CHEMBL486281	184941	0	UNDEFINED	4	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	417	5	2	6	1.7	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCCCC4)cc3)[nH]c2c1=O	None
	11270783	1195	25	UNDEFINED	67	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	None
	5615	1195	25	UNDEFINED	67	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	None
	CHEMBL260933	1195	25	UNDEFINED	67	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	None
	DB05936	1195	25	UNDEFINED	67	4	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	None
	None	215387	0	UNDEFINED	89	3	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	372	4	2	7	-2.6	CCCN1C(=O)C2=C(NC1=O)N=C(N2)C3=CC=C(C=C3)S(=O)(=O)[O-].[Na+]	None
	377	2707	47	UNDEFINED	-1479	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	425	2707	47	UNDEFINED	-1479	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	448222	2707	47	UNDEFINED	-1479	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	CHEMBL464859	2707	47	UNDEFINED	-1479	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	44185936	184942	0	UNDEFINED	12	6	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	522	8	3	7	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL486282	184942	0	UNDEFINED	12	6	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	522	8	3	7	2.4	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	11605883	79527	5	UNDEFINED	42	6	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL212625	79527	5	UNDEFINED	42	6	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	508	7	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	2690	888	59	UNDEFINED	-30	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	384	888	59	UNDEFINED	-30	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	CHEMBL16687	888	59	UNDEFINED	-30	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	163889	1925	15	125I-ABOPX	-6	8	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	None
	446	1925	15	125I-ABOPX	-6	8	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	None
	CHEMBL355370	1925	15	125I-ABOPX	-6	8	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	None
	176407	4069	76	125I-ABOPX	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	176407	4069	76	3H-MRE 3008F20	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	405	4069	76	125I-ABOPX	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	405	4069	76	3H-MRE 3008F20	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	CHEMBL113142	4069	76	125I-ABOPX	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	CHEMBL113142	4069	76	3H-MRE 3008F20	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	DB08770	4069	76	125I-ABOPX	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	DB08770	4069	76	3H-MRE 3008F20	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	176407	4069	76	125I-ABOPX	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	405	4069	76	125I-ABOPX	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	CHEMBL113142	4069	76	125I-ABOPX	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	DB08770	4069	76	125I-ABOPX	-34	6	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	377	2707	47	125I-ABOPX	-1479	15	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	425	2707	47	125I-ABOPX	-1479	15	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	448222	2707	47	125I-ABOPX	-1479	15	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	CHEMBL464859	2707	47	125I-ABOPX	-1479	15	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	1241166	197594	20	UNDEFINED	2	2	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	356	5	1	4	5.8	O=C(c1ccccc1)c1sc(Nc2ccccc2)nc1-c1ccccc1	None
	CHEMBL590302	197594	20	UNDEFINED	2	2	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	356	5	1	4	5.8	O=C(c1ccccc1)c1sc(Nc2ccccc2)nc1-c1ccccc1	None
	2519	765	83	[ 3 H]8-(4-(4-(4-chlorophenyl)piperazine-1-sulfonyl)phenyl)-1-propylxanthine ([3H]PSB-603)	-9	12	Human	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	407	765	83	[ 3 H]8-(4-(4-(4-chlorophenyl)piperazine-1-sulfonyl)phenyl)-1-propylxanthine ([3H]PSB-603)	-9	12	Human	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	463	765	83	[ 3 H]8-(4-(4-(4-chlorophenyl)piperazine-1-sulfonyl)phenyl)-1-propylxanthine ([3H]PSB-603)	-9	12	Human	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	CHEMBL113	765	83	[ 3 H]8-(4-(4-(4-chlorophenyl)piperazine-1-sulfonyl)phenyl)-1-propylxanthine ([3H]PSB-603)	-9	12	Human	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	DB00201	765	83	[ 3 H]8-(4-(4-(4-chlorophenyl)piperazine-1-sulfonyl)phenyl)-1-propylxanthine ([3H]PSB-603)	-9	12	Human	4.5	pKi	=	4.5	Binding	NoneNone	PDSP KiDatabase	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	2690	888	59	UNDEFINED	-30	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	384	888	59	UNDEFINED	-30	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	CHEMBL16687	888	59	UNDEFINED	-30	9	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	7315331	199434	1	UNDEFINED	-5	4	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	352	5	1	5	4.6	CCOC(=O)Nc1nc(-c2ccccc2)c(C(=O)c2ccccc2)s1	None
	CHEMBL603129	199434	1	UNDEFINED	-5	4	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	352	5	1	5	4.6	CCOC(=O)Nc1nc(-c2ccccc2)c(C(=O)c2ccccc2)s1	None
	None	215824	0	UNDEFINED	-3981	4	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	308	3	3	4	3.3	C1CC(CCC1NC2=NC(=NC3=C2C=CN3)C4=CC=CC=C4)O	None
	69550	202394	82	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	238	2	1	7	-1.5	Cn1c(=O)c2c(ncn2CC(=O)O)n(C)c1=O	None
	CHEMBL70246	202394	82	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	238	2	1	7	-1.5	Cn1c(=O)c2c(ncn2CC(=O)O)n(C)c1=O	None
	1892	202338	74	None	34	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	224	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCO)n(C)c1=O	None
	CHEMBL699	202338	74	None	34	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	224	2	1	7	-1.6	Cn1c(=O)c2c(ncn2CCO)n(C)c1=O	None
	2519	765	83	None	-9	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	407	765	83	None	-9	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	463	765	83	None	-9	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	CHEMBL113	765	83	None	-9	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	DB00201	765	83	None	-9	12	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	2153	3728	108	None	-1	14	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2620	3728	108	None	-1	14	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	413	3728	108	None	-1	14	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	CHEMBL190	3728	108	None	-1	14	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	DB00277	3728	108	None	-1	14	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cellsInhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2519	765	83	None	-1	12	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	407	765	83	None	-1	12	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	463	765	83	None	-1	12	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	CHEMBL113	765	83	None	-1	12	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	DB00201	765	83	None	-1	12	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	None
	1329	1439	78	3H-MRE 3008F20	-1288	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	386	1439	78	3H-MRE 3008F20	-1288	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	CHEMBL183	1439	78	3H-MRE 3008F20	-1288	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	DB12946	1439	78	3H-MRE 3008F20	-1288	14	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	163889	1925	15	125I-ABOPX	-6	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	None
	446	1925	15	125I-ABOPX	-6	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	None
	CHEMBL355370	1925	15	125I-ABOPX	-6	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	None
	2690	888	59	3H-cAMP	-30	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	384	888	59	3H-cAMP	-30	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	CHEMBL16687	888	59	3H-cAMP	-30	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	2153	3728	108	None	1	14	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2620	3728	108	None	1	14	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	413	3728	108	None	1	14	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	CHEMBL190	3728	108	None	1	14	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	DB00277	3728	108	None	1	14	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2099	2985	77	None	19	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	None
	4740	2985	77	None	19	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	None
	7095	2985	77	None	19	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	None
	CHEMBL628	2985	77	None	19	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	None
	DB00806	2985	77	None	19	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	None
	1676	98514	53	None	-3	10	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	None
	CHEMBL279898	98514	53	None	-3	10	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandBinding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand	Drug Central	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	None
	44185934	186118	0	UNDEFINED	14	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	403	4	2	6	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCCCC4)cc3)[nH]c2c1=O	None
	CHEMBL488542	186118	0	UNDEFINED	14	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	403	4	2	6	1.3	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCCCC4)cc3)[nH]c2c1=O	None
	None	215385	0	UNDEFINED	-1	11	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	116	4	0	2	1.4	CCCCN(C)N=O	None
	2153	3728	108	None	-21	14	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2620	3728	108	None	-21	14	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	413	3728	108	None	-21	14	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	CHEMBL190	3728	108	None	-21	14	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	DB00277	3728	108	None	-21	14	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membraneDisplacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cell membrane	Drug Central	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	4882	2059	78	None	-104	6	Human	8.2	pKi	=	8.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	Drug Central	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	None
	5311037	2059	78	None	-104	6	Human	8.2	pKi	=	8.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	Drug Central	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	None
	5608	2059	78	None	-104	6	Human	8.2	pKi	=	8.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	Drug Central	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	None
	CHEMBL431770	2059	78	None	-104	6	Human	8.2	pKi	=	8.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	Drug Central	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	None
	DB11757	2059	78	None	-104	6	Human	8.2	pKi	=	8.2	Binding	Inhibition of human recombinant adenosine receptor A2bInhibition of human recombinant adenosine receptor A2b	Drug Central	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	None
	169317	1173	30	125I-ABOPX	-44	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	None
	427	1173	30	125I-ABOPX	-44	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	None
	CHEMBL157655	1173	30	125I-ABOPX	-44	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	None
	176407	4069	76	3H-cAMP	-34	6	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	405	4069	76	3H-cAMP	-34	6	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	CHEMBL113142	4069	76	3H-cAMP	-34	6	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	DB08770	4069	76	3H-cAMP	-34	6	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	None
	176408	3488	79	3H-MRE 3008F20	-407	7	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	None
	176408	3488	79	3H-cAMP	-407	7	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	None
	403	3488	79	3H-MRE 3008F20	-407	7	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	None
	403	3488	79	3H-cAMP	-407	7	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	None
	431	3488	79	3H-MRE 3008F20	-407	7	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	None
	431	3488	79	3H-cAMP	-407	7	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	None
	CHEMBL17127	3488	79	3H-MRE 3008F20	-407	7	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	None
	CHEMBL17127	3488	79	3H-cAMP	-407	7	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	None
	1329	1439	78	3H-PSB-298	-1288	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	1329	1439	78	3H-ZM241385	-1288	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	386	1439	78	3H-PSB-298	-1288	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	386	1439	78	3H-ZM241385	-1288	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	CHEMBL183	1439	78	3H-PSB-298	-1288	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	CHEMBL183	1439	78	3H-ZM241385	-1288	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	DB12946	1439	78	3H-PSB-298	-1288	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	DB12946	1439	78	3H-ZM241385	-1288	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	None	214343	0	125I-ABOPX	-2	5	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	382	7	2	6	2.5	CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)C=CC(=O)O	None
	None	215387	0	UNDEFINED	89	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	372	4	2	7	-2.6	CCCN1C(=O)C2=C(NC1=O)N=C(N2)C3=CC=C(C=C3)S(=O)(=O)[O-].[Na+]	None
	169317	1173	30	125I-ABOPX	-44	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	None
	427	1173	30	125I-ABOPX	-44	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	None
	CHEMBL157655	1173	30	125I-ABOPX	-44	9	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	None
	377	2707	47	UNDEFINED	-1479	15	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	425	2707	47	UNDEFINED	-1479	15	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	448222	2707	47	UNDEFINED	-1479	15	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	CHEMBL464859	2707	47	UNDEFINED	-1479	15	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	10927361	90423	0	UNDEFINED	1	4	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	7	0	7	2.6	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2)n(CCC)c1=O	None
	CHEMBL239233	90423	0	UNDEFINED	1	4	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	7	0	7	2.6	CCCn1c(=O)c2c(nc3n2CCCN3CCc2ccccc2)n(CCC)c1=O	None
	681	1432	65	None	-15	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1432	65	None	-15	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1432	65	None	-15	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1432	65	None	-15	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1432	65	None	-15	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	1676	98514	53	125I-ABOPX	-3	10	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	None
	CHEMBL279898	98514	53	125I-ABOPX	-3	10	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	None
	1676	98514	53	125I-ABOPX	-3	10	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	None
	1676	98514	53	UNDEFINED	-3	10	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	None
	CHEMBL279898	98514	53	125I-ABOPX	-3	10	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	None
	CHEMBL279898	98514	53	UNDEFINED	-3	10	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	4	-0.2	CCCn1c(=O)[nH]c(=O)c2[nH]cnc21	None
	404	4023	30	125I-ABOPX	-229	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	None
	432	4023	30	125I-ABOPX	-229	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	None
	5697	4023	30	125I-ABOPX	-229	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	None
	CHEMBL273094	4023	30	125I-ABOPX	-229	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	None
	1153	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	12668023	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026874	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	30026875	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	3341	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	6603851	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	933	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	939	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	985	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1160786	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL1161520	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	CHEMBL588	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	DB00800	1591	53	None	-5	10	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
	44185932	191013	0	UNDEFINED	11	4	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	508	7	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL519556	191013	0	UNDEFINED	11	4	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	508	7	2	7	1.6	CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	44185933	186117	0	UNDEFINED	35	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	522	8	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	CHEMBL488541	186117	0	UNDEFINED	35	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	522	8	2	7	2.0	CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(CCc5ccccc5)CC4)cc3)[nH]c2c1=O	None
	44437214	168677	0	UNDEFINED	-31	6	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	355	3	1	8	0.6	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccc(O)cc2)n(C)c1=O	None
	CHEMBL441145	168677	0	UNDEFINED	-31	6	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	355	3	1	8	0.6	Cn1c(=O)c2c(nc3n2CCCN3CCc2ccc(O)cc2)n(C)c1=O	None
	1329	1439	78	[3H]DPCPX	-1288	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	386	1439	78	[3H]DPCPX	-1288	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	CHEMBL183	1439	78	[3H]DPCPX	-1288	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	DB12946	1439	78	[3H]DPCPX	-1288	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	None
	2153	3728	108	125I-ABOPX	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2153	3728	108	UNDEFINED	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2620	3728	108	125I-ABOPX	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2620	3728	108	UNDEFINED	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	413	3728	108	125I-ABOPX	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	413	3728	108	UNDEFINED	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	CHEMBL190	3728	108	125I-ABOPX	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	CHEMBL190	3728	108	UNDEFINED	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	DB00277	3728	108	125I-ABOPX	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	DB00277	3728	108	UNDEFINED	-21	14	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2690	888	59	UNDEFINED	-30	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	384	888	59	UNDEFINED	-30	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	CHEMBL16687	888	59	UNDEFINED	-30	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	None
	216466	3772	28	UNDEFINED	-123	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	None
	5605	3772	28	UNDEFINED	-123	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	None
	CHEMBL386974	3772	28	UNDEFINED	-123	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	None
	CHEMBL414157	3772	28	UNDEFINED	-123	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	None
	DB12569	3772	28	UNDEFINED	-123	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	None
	2153	3728	108	UNDEFINED	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2620	3728	108	UNDEFINED	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	413	3728	108	UNDEFINED	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	CHEMBL190	3728	108	UNDEFINED	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	DB00277	3728	108	UNDEFINED	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2153	3728	108	125I-ABOPX	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	2620	3728	108	125I-ABOPX	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	413	3728	108	125I-ABOPX	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	CHEMBL190	3728	108	125I-ABOPX	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	DB00277	3728	108	125I-ABOPX	-21	14	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	None
	11153	1969	40	None	-35	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.	Guide to Pharmacology	315	2	1	5	3.3	Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl	32727810
	86676119	1969	40	None	-35	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.	Guide to Pharmacology	315	2	1	5	3.3	Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl	32727810
	CHEMBL4594442	1969	40	None	-35	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.	Guide to Pharmacology	315	2	1	5	3.3	Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl	32727810
	DB16192	1969	40	None	-35	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.Binding affinity of AZD4635 determined in a radioligand binding competition assays with membranes prepared from HEK-293-T cells stably expressing human A2BR.	Guide to Pharmacology	315	2	1	5	3.3	Nc1nnc(c(n1)c1ccc(cc1)F)c1cc(C)nc(c1)Cl	32727810
	5595	655	21	None	-16595	6	Human	3.4	pKi	=	3.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	5	5	11	-0.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=C/C1CCCCC1)nc2N	16518376
	9576912	655	21	None	-16595	6	Human	3.4	pKi	=	3.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	5	5	11	-0.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=C/C1CCCCC1)nc2N	16518376
	CHEMBL1950554	655	21	None	-16595	6	Human	3.4	pKi	=	3.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	5	5	11	-0.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=C/C1CCCCC1)nc2N	16518376
	DB04853	655	21	None	-16595	6	Human	3.4	pKi	=	3.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	5	5	11	-0.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=C/C1CCCCC1)nc2N	16518376
	423	2656	47	None	-89125	8	Human	3.8	pKi	=	3.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	4	4	9	0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCCC1	6253037
	9841284	2656	47	None	-89125	8	Human	3.8	pKi	=	3.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	4	4	9	0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCCC1	6253037
	CHEMBL45891	2656	47	None	-89125	8	Human	3.8	pKi	=	3.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	4	4	9	0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCCC1	6253037
	3086599	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	10496952
	3086599	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	11093773
	3086599	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	16518376
	375	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	10496952
	375	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	11093773
	375	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	16518376
	424	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	10496952
	424	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	11093773
	424	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	16518376
	CHEMBL331372	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	10496952
	CHEMBL331372	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	11093773
	CHEMBL331372	889	35	None	-3630	8	Human	4.2	pKi	=	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	16518376
	2519	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	407	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	463	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	CHEMBL113	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	DB00201	765	83	None	-47	12	Rat	4.5	pKi	=	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	123807	856	47	None	-13803	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10496952
	123807	856	47	None	-13803	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	16518376
	374	856	47	None	-13803	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10496952
	374	856	47	None	-13803	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	16518376
	379	856	47	None	-13803	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10496952
	379	856	47	None	-13803	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	16518376
	CHEMBL284969	856	47	None	-13803	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	10496952
	CHEMBL284969	856	47	None	-13803	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	4	4	9	0.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1	16518376
	2153	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	11705449
	2153	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	12014951
	2153	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	16219300
	2153	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	18404493
	2620	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	11705449
	2620	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	12014951
	2620	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	16219300
	2620	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	18404493
	413	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	11705449
	413	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	12014951
	413	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	16219300
	413	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	18404493
	CHEMBL190	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	11705449
	CHEMBL190	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	12014951
	CHEMBL190	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	16219300
	CHEMBL190	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	18404493
	DB00277	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	11705449
	DB00277	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	12014951
	DB00277	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	16219300
	DB00277	3728	108	None	-21	14	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	18404493
	123683	3060	58	None	-95499	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10496952
	123683	3060	58	None	-95499	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	16518376
	422	3060	58	None	-95499	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10496952
	422	3060	58	None	-95499	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	16518376
	CHEMBL119709	3060	58	None	-95499	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10496952
	CHEMBL119709	3060	58	None	-95499	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	16518376
	DB05511	3060	58	None	-95499	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10496952
	DB05511	3060	58	None	-95499	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	16518376
	380	1256	49	None	-17782	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10496952
	380	1256	49	None	-17782	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	16518376
	657378	1256	49	None	-17782	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10496952
	657378	1256	49	None	-17782	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	16518376
	CHEMBL68738	1256	49	None	-17782	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	10496952
	CHEMBL68738	1256	49	None	-17782	13	Human	4.6	pKi	=	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	335	4	4	9	-0.2	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1	16518376
	414	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	10496952
	414	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	11093773
	414	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	11266650
	414	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	16219300
	414	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	6253037
	93205	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	10496952
	93205	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	11093773
	93205	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	11266650
	93205	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	16219300
	93205	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	6253037
	CHEMBL139000	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	10496952
	CHEMBL139000	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	11093773
	CHEMBL139000	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	11266650
	CHEMBL139000	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	16219300
	CHEMBL139000	3318	29	None	-19054	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	6253037
	2519	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	12014951
	2519	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	18404493
	2519	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	19569717
	407	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	12014951
	407	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	18404493
	407	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	19569717
	463	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	12014951
	463	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	18404493
	463	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	19569717
	CHEMBL113	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	12014951
	CHEMBL113	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	18404493
	CHEMBL113	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	19569717
	DB00201	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	12014951
	DB00201	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	18404493
	DB00201	765	83	None	-9	12	Human	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	19569717
	414	3318	29	None	-16218	12	Mouse	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	8135856
	93205	3318	29	None	-16218	12	Mouse	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	8135856
	CHEMBL139000	3318	29	None	-16218	12	Mouse	4.7	pKi	=	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C	8135856
	372	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10496952
	372	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	11093773
	372	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	6253037
	8974	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10496952
	8974	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	11093773
	8974	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	6253037
	CHEMBL285819	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	10496952
	CHEMBL285819	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	11093773
	CHEMBL285819	58	96	None	-2630	9	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	2	4	9	-1.3	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N	6253037
	2844	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	2844	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15822182
	2844	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	7746802
	60961	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	60961	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15822182
	60961	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	7746802
	90	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	90	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15822182
	90	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	7746802
	CHEMBL477	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	CHEMBL477	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15822182
	CHEMBL477	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	7746802
	DB00640	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	DB00640	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15822182
	DB00640	280	103	None	-467	8	Human	4.8	pKi	=	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	7746802
	2519	765	83	None	-1	12	Mouse	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	407	765	83	None	-1	12	Mouse	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	463	765	83	None	-1	12	Mouse	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	CHEMBL113	765	83	None	-1	12	Mouse	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	DB00201	765	83	None	-1	12	Mouse	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	194	0	0	6	-1.0	Cn1cnc2c1c(=O)n(C)c(=O)n2C	8135856
	5353365	1180	25	None	-263	6	Rat	5.1	pKi	=	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	330	2	0	6	1.8	Clc1cccc(c1)/C=C/c1nc2c(n1C)c(=O)n(c(=O)n2C)C	None
	5609	1180	25	None	-263	6	Rat	5.1	pKi	=	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	330	2	0	6	1.8	Clc1cccc(c1)/C=C/c1nc2c(n1C)c(=O)n(c(=O)n2C)C	None
	CHEMBL26138	1180	25	None	-263	6	Rat	5.1	pKi	=	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	330	2	0	6	1.8	Clc1cccc(c1)/C=C/c1nc2c(n1C)c(=O)n(c(=O)n2C)C	None
	2153	3728	108	None	1	14	Mouse	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	19141710
	2620	3728	108	None	1	14	Mouse	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	19141710
	413	3728	108	None	1	14	Mouse	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	19141710
	CHEMBL190	3728	108	None	1	14	Mouse	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	19141710
	DB00277	3728	108	None	1	14	Mouse	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	180	0	1	5	-1.0	Cn1c(=O)n(C)c2c(c1=O)[nH]cn2	19141710
	10046145	2635	11	None	-575	6	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	10669571
	10046145	2635	11	None	-575	6	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	15696333
	5610	2635	11	None	-575	6	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	10669571
	5610	2635	11	None	-575	6	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	15696333
	CHEMBL413079	2635	11	None	-575	6	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	10669571
	CHEMBL413079	2635	11	None	-575	6	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	7	1	8	1.1	OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC	15696333
	2844	280	103	None	-158	8	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	60961	280	103	None	-158	8	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	90	280	103	None	-158	8	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	CHEMBL477	280	103	None	-158	8	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	DB00640	280	103	None	-158	8	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	2	4	9	-2.0	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	2099	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	12014951
	4740	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	12014951
	7095	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	12014951
	CHEMBL628	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	12014951
	DB00806	2985	77	None	19	3	Human	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	278	5	0	7	0.2	CC(=O)CCCCn1c(=O)c2n(C)cnc2n(c1=O)C	12014951
	3281	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	9953065	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	CHEMBL4204703	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	CHEMBL592435	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	DB12446	1338	48	None	-4265	7	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	135401232	3145	5	None	-1698	7	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	397	2	1	3	4.4	CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C	12139454
	5619	3145	5	None	-1698	7	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	397	2	1	3	4.4	CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C	12139454
	CHEMBL1562432	3145	5	None	-1698	7	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	397	2	1	3	4.4	CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C	12139454
	135433658	3146	3	None	-208	8	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	1	3	2.5	CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1	12139454
	5620	3146	3	None	-208	8	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	1	3	2.5	CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1	12139454
	9882625	3146	3	None	-208	8	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	1	3	2.5	CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1	12139454
	CHEMBL1625681	3146	3	None	-208	8	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	1	3	2.5	CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1	12139454
	377	2707	47	None	-4265	15	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	425	2707	47	None	-4265	15	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	448222	2707	47	None	-4265	15	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	CHEMBL464859	2707	47	None	-4265	15	Mouse	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	None
	459	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10779381
	459	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	16219300
	459	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	16518376
	477	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10779381
	477	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	16219300
	477	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	16518376
	5310960	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10779381
	5310960	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	16219300
	5310960	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	16518376
	CHEMBL302765	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	10779381
	CHEMBL302765	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	16219300
	CHEMBL302765	2570	31	None	-389	5	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	2	9	3.8	CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC	16518376
	5606	1606	12	None	-1995	6	Human	6.0	pKi	=	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	16518376
	6439091	1606	12	None	-1995	6	Human	6.0	pKi	=	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	16518376
	CHEMBL440115	1606	12	None	-1995	6	Human	6.0	pKi	=	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	5	1	4	3.8	OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1	16518376
	135409562	2144	5	None	-3090	4	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	3	1	3	3.3	CCCn1c2nc([nH]c2c2=NCCn2c1=O)c1ccc(cc1)Br	12063073
	5618	2144	5	None	-3090	4	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	3	1	3	3.3	CCCn1c2nc([nH]c2c2=NCCn2c1=O)c1ccc(cc1)Br	12063073
	CHEMBL2181965	2144	5	None	-3090	4	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	3	1	3	3.3	CCCn1c2nc([nH]c2c2=NCCn2c1=O)c1ccc(cc1)Br	12063073
	176408	3488	79	None	-407	7	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	11093773
	176408	3488	79	None	-407	7	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	16518376
	403	3488	79	None	-407	7	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	11093773
	403	3488	79	None	-407	7	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	16518376
	431	3488	79	None	-407	7	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	11093773
	431	3488	79	None	-407	7	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	16518376
	CHEMBL17127	3488	79	None	-407	7	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	11093773
	CHEMBL17127	3488	79	None	-407	7	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	4	1	8	2.6	Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1	16518376
	377	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10496952
	377	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	11093773
	377	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	11266650
	377	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	377	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15194002
	377	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15267242
	377	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	16219300
	425	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10496952
	425	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	11093773
	425	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	11266650
	425	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	425	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15194002
	425	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15267242
	425	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	16219300
	448222	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10496952
	448222	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	11093773
	448222	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	11266650
	448222	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	448222	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15194002
	448222	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15267242
	448222	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	16219300
	CHEMBL464859	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10496952
	CHEMBL464859	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	11093773
	CHEMBL464859	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	11266650
	CHEMBL464859	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	14662005
	CHEMBL464859	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15194002
	CHEMBL464859	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	15267242
	CHEMBL464859	2707	47	None	-1479	15	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	16219300
	3281	1338	48	None	-537	7	Rat	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	9953065	1338	48	None	-537	7	Rat	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	CHEMBL4204703	1338	48	None	-537	7	Rat	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	CHEMBL592435	1338	48	None	-537	7	Rat	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	DB12446	1338	48	None	-537	7	Rat	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	308	3	3	4	3.3	O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1	17558436
	5613	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	16250647
	9860294	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	16250647
	CHEMBL197669	3616	28	None	-45	4	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	4	1	8	0.9	CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1	16250647
	11717831	578	39	None	-60	5	Mouse	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	17632123
	3289	578	39	None	-60	5	Mouse	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	17632123
	CHEMBL4202825	578	39	None	-60	5	Mouse	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	17632123
	5604	3304	31	None	-1995	10	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	17125264
	64627	3304	31	None	-1995	10	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	17125264
	CHEMBL52333	3304	31	None	-1995	10	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	17125264
	DB05360	3304	31	None	-1995	10	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	5	1	5	2.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3	17125264
	1329	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12014951
	1329	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12954362
	386	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12014951
	386	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12954362
	CHEMBL183	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12014951
	CHEMBL183	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12954362
	DB12946	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12014951
	DB12946	1439	78	None	-1905	14	Rat	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12954362
	11689583	3153	24	None	-1513	7	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	7	2	6	2.1	OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3	16458010
	3285	3153	24	None	-1513	7	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	7	2	6	2.1	OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3	16458010
	CHEMBL1316674	3153	24	None	-1513	7	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	7	2	6	2.1	OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3	16458010
	11224	575	28	None	-	1	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906
	118016229	575	28	None	-	1	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906
	CHEMBL4522981	575	28	None	-	1	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	433	4	1	7	2.1	CCn1c(=O)c2c(C)c(sc2n(c1=O)CCC(F)(F)F)C(=O)N1CCC(CC1)O	30576906
	2690	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10624567
	2690	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	11266650
	2690	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	15194002
	2690	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	19141710
	2690	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	9459566
	2690	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	9933143
	384	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10624567
	384	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	11266650
	384	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	15194002
	384	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	19141710
	384	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	9459566
	384	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	9933143
	CHEMBL16687	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	10624567
	CHEMBL16687	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	11266650
	CHEMBL16687	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	15194002
	CHEMBL16687	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	19141710
	CHEMBL16687	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	9459566
	CHEMBL16687	888	59	None	-30	9	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	9933143
	216466	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	17125264
	5605	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	17125264
	CHEMBL386974	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	17125264
	CHEMBL414157	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	17125264
	DB12569	3772	28	None	-123	6	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	416	8	2	6	3.2	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O	17125264
	1329	1439	78	None	-870	14	Mouse	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	19141710
	386	1439	78	None	-870	14	Mouse	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	19141710
	CHEMBL183	1439	78	None	-870	14	Mouse	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	19141710
	DB12946	1439	78	None	-870	14	Mouse	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	19141710
	1329	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12014951
	1329	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	15194002
	1329	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	16020631
	1329	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	16902942
	386	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12014951
	386	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	15194002
	386	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	16020631
	386	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	16902942
	CHEMBL183	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12014951
	CHEMBL183	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	15194002
	CHEMBL183	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	16020631
	CHEMBL183	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	16902942
	DB12946	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	12014951
	DB12946	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	15194002
	DB12946	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	16020631
	DB12946	1439	78	None	-1288	14	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	304	5	1	5	2.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1	16902942
	21874557	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	19072055
	5612	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	19072055
	CHEMBL447664	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	19072055
	DB06625	3921	46	None	-52	4	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	3	2	8	2.0	Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N	19072055
	3286	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	11906291
	5311479	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	11906291
	CHEMBL8565	3148	24	None	4	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	4	3	6	0.7	CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O	11906291
	11270783	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	18321039
	5615	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	18321039
	CHEMBL260933	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	18321039
	DB05936	1195	25	None	67	4	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	446	6	1	7	3.2	CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F	18321039
	11716665	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	17469811
	11716665	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	20137946
	5617	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	17469811
	5617	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	20137946
	CHEMBL375293	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	17469811
	CHEMBL375293	2240	29	None	58	4	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	4	1	7	3.3	n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1	20137946
	449	2595	44	None	-9	9	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10737749
	449	2595	44	None	-9	9	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	12954362
	453	2595	44	None	-9	9	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10737749
	453	2595	44	None	-9	9	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	12954362
	6603931	2595	44	None	-9	9	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10737749
	6603931	2595	44	None	-9	9	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	12954362
	CHEMBL273807	2595	44	None	-9	9	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10737749
	CHEMBL273807	2595	44	None	-9	9	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	12954362
	404	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10496952
	404	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10624567
	404	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	11093773
	404	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	11266650
	404	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	15194002
	404	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	9459566
	432	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10496952
	432	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10624567
	432	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	11093773
	432	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	11266650
	432	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	15194002
	432	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	9459566
	5697	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10496952
	5697	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10624567
	5697	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	11093773
	5697	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	11266650
	5697	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	15194002
	5697	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	9459566
	CHEMBL273094	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10496952
	CHEMBL273094	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	10624567
	CHEMBL273094	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	11093773
	CHEMBL273094	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	11266650
	CHEMBL273094	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	15194002
	CHEMBL273094	4023	30	None	-229	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	10	3	8	0.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN	9459566
	2690	888	59	None	-11	9	Mouse	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	19141710
	384	888	59	None	-11	9	Mouse	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	19141710
	CHEMBL16687	888	59	None	-11	9	Mouse	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	285	1	1	6	2.8	Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1	19141710
	24780383	512	0	None	-3	8	Mouse	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	513	6	1	8	3.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)C1CC1)c1ccc(nc1)N(C(=O)c1ccc(nc1)C(F)(F)F)C	10737749
	5616	512	0	None	-3	8	Mouse	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	513	6	1	8	3.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)C1CC1)c1ccc(nc1)N(C(=O)c1ccc(nc1)C(F)(F)F)C	10737749
	11717831	578	39	None	60	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	17353435
	3289	578	39	None	60	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	17353435
	CHEMBL4202825	578	39	None	60	5	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	2	7	2.4	N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N	17353435
	135484064	2568	3	None	21	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	14998332
	135484064	2568	3	None	21	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	16219300
	390	2568	3	None	21	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	14998332
	390	2568	3	None	21	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	16219300
	CHEMBL260331	2568	3	None	21	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	14998332
	CHEMBL260331	2568	3	None	21	4	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	2	11	1.9	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2	16219300
	11223	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	26824742
	17198004	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	26824742
	CHEMBL3787197	2038	18	None	-1	4	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	6	3.9	CC(OC(=O)C1=C(C)Nc2n(C1c1ccco1)c1ccccc1n2)C	26824742
	449	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	19141710
	453	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	19141710
	6603931	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	19141710
	CHEMBL273807	2595	44	None	-2	9	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	19141710
	24780383	512	0	None	3	8	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	513	6	1	8	3.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)C1CC1)c1ccc(nc1)N(C(=O)c1ccc(nc1)C(F)(F)F)C	10737749
	5616	512	0	None	3	8	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	513	6	1	8	3.4	CCCn1c2nc([nH]c2c(=O)n(c1=O)C1CC1)c1ccc(nc1)N(C(=O)c1ccc(nc1)C(F)(F)F)C	10737749
	449	2595	44	None	-1	9	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10737749
	449	2595	44	None	-1	9	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	11266650
	453	2595	44	None	-1	9	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10737749
	453	2595	44	None	-1	9	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	11266650
	6603931	2595	44	None	-1	9	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10737749
	6603931	2595	44	None	-1	9	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	11266650
	CHEMBL273807	2595	44	None	-1	9	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	10737749
	CHEMBL273807	2595	44	None	-1	9	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	2	8	3.3	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N	11266650
	3284	3155	28	None	-1	7	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	44185871	3155	28	None	-1	7	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	5728	3155	28	None	-1	7	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	CHEMBL483688	3155	28	None	-1	7	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	6	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl	19569717
	44186581	3144	23	None	851	6	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	19569717
	6561	3144	23	None	851	6	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	19569717
	CHEMBL482436	3144	23	None	851	6	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	542	7	2	7	2.7	CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc(cc1)Cl	19569717
	11561692	1831	8	None	-239	4	Human	4.3	pKi	>	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	6	4	10	1.7	O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N[C@@H]1CCC[C@H]1O)CSc1ccccc1F	19012505
	5593	1831	8	None	-239	4	Human	4.3	pKi	>	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	6	4	10	1.7	O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N[C@@H]1CCC[C@H]1O)CSc1ccccc1F	19012505
	CHEMBL3545011	1831	8	None	-239	4	Human	4.3	pKi	>	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	6	4	10	1.7	O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N[C@@H]1CCC[C@H]1O)CSc1ccccc1F	19012505
	10981286	1880	24	None	-28183	4	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	12109910
	10981286	1880	24	None	-28183	4	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	17126322
	5599	1880	24	None	-28183	4	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	12109910
	5599	1880	24	None	-28183	4	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	17126322
	5736	1880	24	None	-28183	4	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	12109910
	5736	1880	24	None	-28183	4	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	17126322
	CHEMBL260563	1880	24	None	-28183	4	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	12109910
	CHEMBL260563	1880	24	None	-28183	4	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	5	4	9	0.0	CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	17126322
	3086599	889	35	None	-575	8	Rat	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	None
	375	889	35	None	-575	8	Rat	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	None
	424	889	35	None	-575	8	Rat	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	None
	CHEMBL331372	889	35	None	-575	8	Rat	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	499	10	6	11	-0.2	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N	None
	3035850	936	65	None	-54954	14	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	None
	3035850	936	65	None	-54954	14	Mouse	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	None
	457	936	65	None	-54954	14	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	None
	457	936	65	None	-54954	14	Mouse	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	None
	CHEMBL431733	936	65	None	-54954	14	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	None
	CHEMBL431733	936	65	None	-54954	14	Mouse	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	None
	DB12885	936	65	None	-54954	14	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	None
	DB12885	936	65	None	-54954	14	Mouse	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	None
	4882	2059	78	None	-104	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	21303899
	5311037	2059	78	None	-104	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	21303899
	5608	2059	78	None	-104	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	21303899
	CHEMBL431770	2059	78	None	-104	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	21303899
	DB11757	2059	78	None	-104	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	6	0	8	2.1	COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC	21303899
	393594	2588	35	None	-1949	7	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	6	1	5	5.2	CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1	None
	470	2588	35	None	-1949	7	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	6	1	5	5.2	CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1	None
	CHEMBL1995014	2588	35	None	-1949	7	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	6	1	5	5.2	CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1	None
	CHEMBL89852	2588	35	None	-1949	7	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	6	1	5	5.2	CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1	None
	3661570	2593	47	None	-102	9	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	399	9	0	5	5.7	CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC	None
	3661570	2593	47	None	-102	9	Mouse	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	399	9	0	5	5.7	CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC	None
	474	2593	47	None	-102	9	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	399	9	0	5	5.7	CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC	None
	474	2593	47	None	-102	9	Mouse	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	399	9	0	5	5.7	CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC	None
	CHEMBL111545	2593	47	None	-102	9	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	399	9	0	5	5.7	CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC	None
	CHEMBL111545	2593	47	None	-102	9	Mouse	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	399	9	0	5	5.7	CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC	None
	11248240	2616	2	None	-34673	10	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	16518376
	5601	2616	2	None	-34673	10	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	16518376
	CHEMBL175543	2616	2	None	-34673	10	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	16518376
	219024	3236	61	None	-229	5	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	16518376
	2362	3236	61	None	-229	5	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	16518376
	5596	3236	61	None	-229	5	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	16518376
	CHEMBL317052	3236	61	None	-229	5	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	16518376
	DB06213	3236	61	None	-229	5	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	16518376
	10668061	3484	64	None	-64565	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	389	6	1	9	3.0	COc1ccc(cc1)CCCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1	16518376
	3283	3484	64	None	-64565	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	389	6	1	9	3.0	COc1ccc(cc1)CCCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1	16518376
	CHEMBL136689	3484	64	None	-64565	6	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	389	6	1	9	3.0	COc1ccc(cc1)CCCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1	16518376
	135546224	3694	0	None	-3548	4	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	7	6	11	1.8	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=N/C(=O)Nc1ccccc1)nc2NC1CCCC1	9384502
	136218973	3694	0	None	-3548	4	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	7	6	11	1.8	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=N/C(=O)Nc1ccccc1)nc2NC1CCCC1	9384502
	5590	3694	0	None	-3548	4	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	7	6	11	1.8	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=N/C(=O)Nc1ccccc1)nc2NC1CCCC1	9384502
	CHEMBL2113457	3694	0	None	-3548	4	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	7	6	11	1.8	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=N/C(=O)Nc1ccccc1)nc2NC1CCCC1	9384502
	10117987	3103	76	None	-1047	6	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	503	9	1	12	2.2	COCCOc1ccc(cc1)N1CCN(CC1)CCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1	18221214
	5614	3103	76	None	-1047	6	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	503	9	1	12	2.2	COCCOc1ccc(cc1)N1CCN(CC1)CCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1	18221214
	CHEMBL240624	3103	76	None	-1047	6	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	503	9	1	12	2.2	COCCOc1ccc(cc1)N1CCN(CC1)CCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1	18221214
	DB11864	3103	76	None	-1047	6	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	503	9	1	12	2.2	COCCOc1ccc(cc1)N1CCN(CC1)CCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1	18221214
	16109435	2337	7	None	-338	4	Human	6.5	pKi	>	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	3	1	2	6.3	C1CCC(CC1)c1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1	14663020
	5607	2337	7	None	-338	4	Human	6.5	pKi	>	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	3	1	2	6.3	C1CCC(CC1)c1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1	14663020
	CHEMBL219160	2337	7	None	-338	4	Human	6.5	pKi	>	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	3	1	2	6.3	C1CCC(CC1)c1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1	14663020
	415	3581	12	None	-1905	9	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C	10496952
	415	3581	12	None	-1905	9	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C	16219300
	5312112	3581	12	None	-1905	9	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C	10496952
	5312112	3581	12	None	-1905	9	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C	16219300
	CHEMBL420705	3581	12	None	-1905	9	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C	10496952
	CHEMBL420705	3581	12	None	-1905	9	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	4	9	0.5	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C	16219300
	434	221	0	None	-	1	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	457	6	6	11	-0.7	CCNC(=O)C(=O)Nc1nc(Nc2ccccc2)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	10496952
	57340157	221	0	None	-	1	Human	4.7	pKi	None	4.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	457	6	6	11	-0.7	CCNC(=O)C(=O)Nc1nc(Nc2ccccc2)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO	10496952
	456	346	51	None	15	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	10624567
	456	346	51	None	15	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	11266650
	5372720	346	51	None	15	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	10624567
	5372720	346	51	None	15	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	11266650
	CHEMBL68500	346	51	None	15	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	10624567
	CHEMBL68500	346	51	None	15	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	214	0	2	4	0.2	O=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1	11266650
	10221256	104	0	None	-	1	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	2	5	0.7	CC(Cn1c(=O)[nH]c(=O)c2c1nc([nH]2)N1CCCC1)C	11705449
	447	104	0	None	-	1	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	2	5	0.7	CC(Cn1c(=O)[nH]c(=O)c2c1nc([nH]2)N1CCCC1)C	11705449
	444	1301	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	5	1	5	2.3	C=CCn1c2nc([nH]c2c(=O)n(c1=O)CC=C)C1CCCCC1	11266650
	9926882	1301	0	None	-	1	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	5	1	5	2.3	C=CCn1c2nc([nH]c2c(=O)n(c1=O)CC=C)C1CCCCC1	11266650
	393595	2589	46	None	-97	6	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	6	4.4	O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1	15194002
	448	2589	46	None	-97	6	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	6	4.4	O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1	15194002
	CHEMBL88147	2589	46	None	-97	6	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	6	4.4	O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1	15194002
	164437	64	21	None	-114	7	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	5	4	9	-0.3	CCCCC#Cc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(=O)NCC	16219300
	373	64	21	None	-114	7	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	5	4	9	-0.3	CCCCC#Cc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(=O)NCC	16219300
	CHEMBL410873	64	21	None	-114	7	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	5	4	9	-0.3	CCCCC#Cc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(=O)NCC	16219300
	443	742	7	None	-3	7	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10496952
	6439089	742	7	None	-3	7	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10496952
	CHEMBL16997	742	7	None	-3	7	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	7	2	6	2.5	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O	10496952
	169317	1173	30	None	-44	9	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	10496952
	169317	1173	30	None	-44	9	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	11266650
	427	1173	30	None	-44	9	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	10496952
	427	1173	30	None	-44	9	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	11266650
	CHEMBL157655	1173	30	None	-44	9	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	10496952
	CHEMBL157655	1173	30	None	-44	9	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	236	4	1	5	0.7	CCCn1c(=O)n(CCC)c2c(c1=O)[nH]cn2	11266650
	126079	4025	20	None	-2	8	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	11266650
	451	4025	20	None	-2	8	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	11266650
	CHEMBL27041	4025	20	None	-2	8	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	8	2	7	1.8	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)O	11266650
	163889	1925	15	None	-6	8	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	10496952
	446	1925	15	None	-6	8	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	10496952
	CHEMBL355370	1925	15	None	-6	8	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	575	8	3	8	2.7	CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O	10496952
	176407	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10496952
	176407	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	11093773
	176407	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	11266650
	176407	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	15194002
	405	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10496952
	405	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	11093773
	405	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	11266650
	405	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	15194002
	CHEMBL113142	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10496952
	CHEMBL113142	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	11093773
	CHEMBL113142	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	11266650
	CHEMBL113142	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	15194002
	DB08770	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	10496952
	DB08770	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	11093773
	DB08770	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	11266650
	DB08770	4069	76	None	-34	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	5	3	9	1.7	Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1	15194002
	135465785	485	0	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	16219300
	439	485	0	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	16219300
	CHEMBL32582	485	0	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	496	8	2	12	0.0	CCCn1c2=N/C(=c/3\o[nH]c(c3)OCC(=O)Nc3ccc4c(c3)OCO4)/N=c2c(=O)n(c1=O)CCC	16219300
	135529391	478	0	None	-	1	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	16219300
	438	478	0	None	-	1	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	16219300
	CHEMBL285900	478	0	None	-	1	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	555	10	2	10	1.5	CCCn1c2=N/C(=c\3/cc([nH]n3C)NC(=O)Cc3ccc(cc3)OCc3ccccc3)/N=c2c(=O)n(c1=O)CCC	16219300
	135443359	487	0	None	-	1	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	16219300
	441	487	0	None	-	1	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	16219300
	CHEMBL431703	487	0	None	-	1	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	509	9	3	11	-0.1	CCCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)Nc3ccc(cc3)C(=O)O)/N=c2c(=O)n(c1=O)CCC	16219300
	135529386	486	0	None	-	1	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	16219300
	440	486	0	None	-	1	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	16219300
	CHEMBL284615	486	0	None	-	1	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	537	10	2	12	0.4	CCOC(=O)c1ccc(cc1)NC(=O)COc1c/c(=C\2/N=c3c(=N2)c(=O)n(c(=O)n3CCC)CCC)/n([nH]1)C	16219300
	1328	1337	30	None	-7	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	10496952
	445	1337	30	None	-7	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	10496952
	CHEMBL11348	1337	30	None	-7	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	3	1	5	1.6	CCn1c2nc([nH]c2c(=O)n(c1=O)CC)c1ccccc1	10496952
	135416058	488	0	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	16219300
	442	488	0	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	16219300
	CHEMBL2113342	488	0	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	530	8	1	11	-0.5	C=CCn1c2=N/C(=c\3/cc([nH]n3C)OCC(=O)N3CCN(CC3)c3ccccc3)/N=c2c(=O)n(c1=O)CC=C	16219300
	135443367	484	0	None	22	2	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	16219300
	382	484	0	None	22	2	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	16219300
	CHEMBL33455	484	0	None	22	2	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	534	9	1	10	1.8	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)N1CCN(CC1)c1ccccc1	16219300
	135489238	474	0	None	30	2	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	16219300
	381	474	0	None	30	2	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	16219300
	CHEMBL32802	474	0	None	30	2	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	533	9	2	9	3.4	CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)Cl)Cl	16219300
	135476605	475	0	None	-	1	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	2	13	0.2	CCCn1c2=N/C(=c\3/cc([nH]n3C)OC(=O)CNc3ccc(c(c3)OC)OC)/N=c2c(=O)n(c1=O)CCC	16219300
	437	475	0	None	-	1	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	2	13	0.2	CCCn1c2=N/C(=c\3/cc([nH]n3C)OC(=O)CNc3ccc(c(c3)OC)OC)/N=c2c(=O)n(c1=O)CCC	16219300
	135522368	489	1	None	117	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	16219300
	383	489	1	None	117	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	16219300
	CHEMBL33491	489	1	None	117	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	493	9	2	9	2.7	CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc(c(c1)C)C	16219300
	450	2911	8	None	257	4	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	15194002
	454	2911	8	None	257	4	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	15194002
	5311041	2911	8	None	257	4	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	15194002
	CHEMBL485862	2911	8	None	257	4	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	525	10	3	6	3.6	CC(=O)NCCNc1nc(nc2c1cc([nH]2)C(=O)N1CCN(CC1)CCCc1ccccc1)c1ccccc1	15194002

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Ligand source activities (1 row/activity)