Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
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name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
11656002 82585 23 None 61 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm301071h
CHEMBL2181247 82585 23 None 61 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm301071h
90644451 111706 0 None 3 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290717 111706 0 None 3 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71561754 87202 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2336232 87202 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
126673452 160594 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4087611 160594 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117342 160594 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71462787 82567 0 None 3 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181229 82567 0 None 3 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
155669602 181348 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 372 4 0 4 4.1 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4779837 181348 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 372 4 0 4 4.1 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118577239 160424 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060410 160424 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116055 160424 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71626699 111705 0 None 5 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290716 111705 0 None 5 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71455634 82565 0 None 4 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181227 82565 0 None 4 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
90654589 109457 0 None 1 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234570 109457 0 None 1 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654598 109505 0 None 21 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
CHEMBL3234869 109505 0 None 21 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
71462786 82566 0 None 3 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
CHEMBL2181228 82566 0 None 3 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
71450251 82564 23 None 8 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181226 82564 23 None 8 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71461054 82569 0 None 3 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181230 82569 0 None 3 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
118576935 157395 0 None 43 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4084668 157395 0 None 43 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118576930 158257 0 None 25 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
CHEMBL4094487 158257 0 None 25 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
156705093 181298 0 None 25 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4779084 181298 0 None 25 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90644451 111706 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290717 111706 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71462787 82567 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181229 82567 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
90654589 109457 0 None -1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234570 109457 0 None -1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
46232571 200918 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
CHEMBL612138 200918 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
118103672 163887 0 None 31 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213913 163887 0 None 31 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
90654587 109454 0 None -1 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 109454 0 None -1 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654597 109504 0 None 17 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234868 109504 0 None 17 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90654600 109507 0 None 8 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 109507 0 None 8 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
162645557 179084 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 323 4 0 3 3.9 C[C@H](c1ccccc1)n1cncc1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmc.2020.115972
CHEMBL4743463 179084 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 323 4 0 3 3.9 C[C@H](c1ccccc1)n1cncc1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmc.2020.115972
162669860 182153 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 378 4 0 4 3.6 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2020.115972
CHEMBL4790044 182153 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 378 4 0 4 3.6 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2020.115972
71561753 87201 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336231 87201 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
71561756 87203 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336233 87203 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
71599441 162989 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 162989 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71599441 162989 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 162989 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71626700 111704 0 None 7 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290715 111704 0 None 7 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71626488 111702 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290713 111702 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
53311869 82578 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181239 82578 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
89501409 160801 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 6 7.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4126062 160801 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 6 7.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
71540074 86850 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331649 86850 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
77845059 111709 0 None 22 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290720 111709 0 None 22 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71561755 86841 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2331604 86841 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
76314787 105529 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 382 5 0 5 4.1 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1039/C2MD20174G
CHEMBL3132966 105529 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 382 5 0 5 4.1 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1039/C2MD20174G
118103698 163109 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4204655 163109 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093476 163540 0 None 39 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209669 163540 0 None 39 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118104387 163549 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 718 15 4 8 3.0 O=C(O)CNC(=O)CNC(=O)CNC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209799 163549 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 718 15 4 8 3.0 O=C(O)CNC(=O)CNC(=O)CNC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
145974037 164191 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4217797 164191 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4212707 211514 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL None None None O=C(O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CCC(NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O)C(=O)NCC(=O)O)NC(=O)CCC(NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
91972025 155405 0 None 43 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4061329 155405 0 None 43 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
46195848 82584 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181246 82584 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
46232694 199219 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601637 199219 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232696 199845 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCc1onc(-c2ccccc2Cl)c1C(=O)N(CC)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605367 199845 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCc1onc(-c2ccccc2Cl)c1C(=O)N(CC)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
76318386 105532 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132969 105532 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
118093484 162959 0 None 31 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202656 162959 0 None 31 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093390 163307 0 None 19 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4206832 163307 0 None 19 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118093562 163324 0 None 5 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207005 163324 0 None 5 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103738 163325 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 669 12 4 6 5.0 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCP(=O)(O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4207008 163325 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 669 12 4 6 5.0 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCP(=O)(O)O 10.1021/acs.jmedchem.8b00308
118103697 163394 0 None 7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207801 163394 0 None 7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103728 163440 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 853 20 7 12 1.8 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4208317 163440 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 853 20 7 12 1.8 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
71661092 163489 0 None 10 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4208999 163489 0 None 10 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
118103732 163523 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 14 2 7 5.1 O=C(O)CN(CCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)CC(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4209515 163523 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 14 2 7 5.1 O=C(O)CN(CCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)CC(=O)O 10.1021/acs.jmedchem.8b00308
71626700 111704 0 None -7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290715 111704 0 None -7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654593 109467 0 None 2 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234580 109467 0 None 2 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
164613236 183914 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 3 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4847424 183914 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 3 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
155339362 172509 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N3CCCC3)[C@@H]21 10.1021/acs.jmedchem.9b00770
CHEMBL4519993 172509 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N3CCCC3)[C@@H]21 10.1021/acs.jmedchem.9b00770
71626492 111695 0 None 2 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290706 111695 0 None 2 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
168288290 190750 0 None 95 2 Human 7.0 pEC50 = 7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 6 0 3 5.0 CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5192002 190750 0 None 95 2 Human 7.0 pEC50 = 7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 6 0 3 5.0 CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
156016578 177122 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 399 4 2 3 5.5 C=CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4642126 177122 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 399 4 2 3 5.5 C=CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
118093575 163065 1 None -6 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203848 163065 1 None -6 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118103679 163385 0 None -39 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4207707 163385 0 None -39 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118103700 163420 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4208057 163420 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71661092 163489 0 None -10 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4208999 163489 0 None -10 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
118103668 163844 0 None -7 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213391 163844 0 None -7 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145972818 164079 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
CHEMBL4216361 164079 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
118103734 164087 0 None -25 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4216584 164087 0 None -25 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
46233056 197689 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590982 197689 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.01.003
73357024 92267 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435926 92267 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71660979 162979 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4202908 162979 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660960 163027 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4203445 163027 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
71661220 163058 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203777 163058 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
168280068 190585 0 None 5 2 Human 6.0 pEC50 = 6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 293 6 0 3 4.6 CCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5189181 190585 0 None 5 2 Human 6.0 pEC50 = 6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 293 6 0 3 4.6 CCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
44457490 157374 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 458 5 4 5 3.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL408445 157374 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 458 5 4 5 3.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118093441 163209 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4205745 163209 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71661224 163577 0 None -1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210112 163577 0 None -1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660910 163694 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4211549 163694 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
46232410 198881 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 4 0 3 5.1 CCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599126 198881 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 4 0 3 5.1 CCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46232569 199427 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603096 199427 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
71660910 163694 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4211549 163694 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
89651284 164083 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
CHEMBL4216520 164083 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
45483949 3512 28 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
7048 3512 28 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
CHEMBL567640 3512 28 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
439763 157569 18 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1039/d0md00425a
CHEMBL408701 157569 18 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1039/d0md00425a
90644448 111725 0 None -2 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290736 111725 0 None -2 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
76314788 105530 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 383 5 0 6 3.5 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cn2)c1 10.1039/C2MD20174G
CHEMBL3132967 105530 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 383 5 0 6 3.5 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cn2)c1 10.1039/C2MD20174G
71561884 87206 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336236 87206 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
101886302 114399 32 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 5 3 3 5.0 CC[C@@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCO)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/jm501273r
CHEMBL3342082 114399 32 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 5 3 3 5.0 CC[C@@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCO)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/jm501273r
136166966 91165 0 None 4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 91165 0 None 4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
3945 618 85 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
64971 618 85 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
CHEMBL269277 618 85 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
DB12480 618 85 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
9929677 157131 3 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL408175 157131 3 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
71561753 87201 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336231 87201 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
67922813 117159 1 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401352 117159 1 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
71561885 87207 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336237 87207 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
118464662 158581 0 None 22 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4097990 158581 0 None 22 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
73353937 92259 0 None -20 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435914 92259 0 None -20 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
94192 16826 14 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 388 4 1 3 4.9 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
CHEMBL1254261 16826 14 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 388 4 1 3 4.9 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
90654598 109505 0 None -21 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
CHEMBL3234869 109505 0 None -21 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
76336516 105534 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 405 5 0 5 4.6 CCc1onc(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(C(F)(F)F)nc1 10.1039/C2MD20174G
CHEMBL3132970 105534 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 405 5 0 5 4.6 CCc1onc(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(C(F)(F)F)nc1 10.1039/C2MD20174G
90654585 109452 0 None -2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
CHEMBL3234566 109452 0 None -2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
71540073 86849 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assayAgonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 86849 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assayAgonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626765 118306 0 None -2 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421893 118306 0 None -2 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118586281 158005 0 None -7 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4091702 158005 0 None -7 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
126673489 156118 0 None -13 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4069569 156118 0 None -13 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
71540174 86855 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331654 86855 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71561370 87188 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336215 87188 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
156705090 181115 0 None -54 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4776876 181115 0 None -54 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
164621408 185159 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 436 5 4 4 3.9 CC[C@H]1[C@@H](O)[C@@H]2[C@H](C[C@H](O)[C@H]3[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4866257 185159 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 436 5 4 4 3.9 CC[C@H]1[C@@H](O)[C@@H]2[C@H](C[C@H](O)[C@H]3[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@H]12 10.1021/acs.jmedchem.1c00851
137629931 160457 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4064764 160457 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116312 160457 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
155669593 182630 0 None 31 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4796107 182630 0 None 31 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
3035026 95327 37 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL258605 95327 37 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
73353943 92285 0 None -3 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435945 92285 0 None -3 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
90327533 111719 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 10 1 8 5.5 CCOC(=O)CNC(=O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290730 111719 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 10 1 8 5.5 CCOC(=O)CNC(=O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673464 158606 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 556 12 1 7 6.6 COc1ccc(N(C)c2c(CCCCN)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4098315 158606 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 556 12 1 7 6.6 COc1ccc(N(C)c2c(CCCCN)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71561368 87186 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336213 87186 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
118709772 113048 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 460 4 0 6 5.4 CSc1ncc(C(=O)N2CCN(C)c3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
CHEMBL3321843 113048 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 460 4 0 6 5.4 CSc1ncc(C(=O)N2CCN(C)c3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
71455632 82561 0 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181223 82561 0 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71455633 82562 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 431 6 0 6 4.5 COc1ccc(OC)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181224 82562 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 431 6 0 6 4.5 COc1ccc(OC)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71457418 82563 0 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
CHEMBL2181225 82563 0 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
90654594 109468 0 None -3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234581 109468 0 None -3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576974 156633 0 None 10 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4075688 156633 0 None 10 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
46232360 197625 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 496 3 0 3 6.4 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cc(Br)c(C)c(Br)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590495 197625 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 496 3 0 3 6.4 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cc(Br)c(C)c(Br)c1 10.1016/j.bmcl.2010.01.003
46232566 199118 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccc(Cl)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600821 199118 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccc(Cl)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232532 199192 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2cccc(Cl)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601441 199192 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2cccc(Cl)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232736 199613 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604131 199613 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232567 199686 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604537 199686 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103692 163833 0 None - 1 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 768 17 6 11 1.9 O=C(O)CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4213249 163833 0 None - 1 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 768 17 6 11 1.9 O=C(O)CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103668 163844 0 None 7 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213391 163844 0 None 7 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44627312 197302 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL585494 197302 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
74766512 156893 0 None 3 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4079040 156893 0 None 3 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118464638 158976 0 None 15 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102357 158976 0 None 15 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71720725 87209 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336239 87209 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
5284060 97032 9 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270287 97032 9 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
73350995 92283 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435943 92283 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
90654577 109444 0 None 17 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234558 109444 0 None 17 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
156020210 177562 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 4 2 3 5.7 CCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4648823 177562 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 4 2 3 5.7 CCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
71626833 118309 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421897 118309 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118735268 118316 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421904 118316 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71626559 111697 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2[nH]ccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290708 111697 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2[nH]ccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
118721858 115575 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 1 3 3.3 CN1CCN(C(=O)C2(C(=O)Nc3cc(F)c(F)cc3F)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3356914 115575 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 1 3 3.3 CN1CCN(C(=O)C2(C(=O)Nc3cc(F)c(F)cc3F)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
164609554 183821 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 2 3 8.3 CC(C)NC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4846090 183821 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 2 3 8.3 CC(C)NC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
45483949 3512 28 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
7048 3512 28 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
CHEMBL567640 3512 28 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
73353944 92286 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 532 7 0 3 8.2 CCC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435946 92286 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 532 7 0 3 8.2 CCC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
118455158 157025 0 None 100 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4080612 157025 0 None 100 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71599441 162989 0 None -109 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 162989 0 None -109 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118093493 163008 0 None 3 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203191 163008 0 None 3 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
71660960 163027 0 None -1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4203445 163027 0 None -1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
145978106 163262 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206320 163262 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093410 164221 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4218210 164221 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46233022 199070 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 452 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(I)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600421 199070 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 452 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(I)cc1 10.1016/j.bmcl.2010.01.003
46233052 199097 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600629 199097 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
145978106 163262 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206320 163262 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093410 164221 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4218210 164221 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
222528 1336 77 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
4988 1336 77 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
610 1336 77 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
CHEMBL406393 1336 77 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
DB03619 1336 77 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
44372853 119377 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 CC(CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL349105 119377 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 CC(CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
118455158 157025 0 None -100 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4080612 157025 0 None -100 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118455116 155639 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 1 5 7.4 COc1cc(C2(CO)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4064131 155639 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 1 5 7.4 COc1cc(C2(CO)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
46232658 197837 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 0 3 4.9 CN(C(=O)c1conc1-c1ccccc1Cl)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL592158 197837 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 0 3 4.9 CN(C(=O)c1conc1-c1ccccc1Cl)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232412 198882 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 3 5.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599127 198882 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 3 5.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)C)cc1 10.1016/j.bmcl.2010.01.003
46232875 199069 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
CHEMBL600410 199069 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
46233024 199071 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
CHEMBL600422 199071 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
46232597 199538 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccc(C(F)(F)F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603706 199538 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccc(C(F)(F)F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118093441 163209 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4205745 163209 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71661223 163870 0 None 1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213705 163870 0 None 1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232488 199882 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 4 4.8 CC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605554 199882 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 4 4.8 CC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
71452077 82573 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 400 3 0 4 5.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCOc2ccccc21 10.1021/jm301071h
CHEMBL2181234 82573 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 400 3 0 4 5.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCOc2ccccc21 10.1021/jm301071h
73347898 92276 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 466 6 0 2 6.7 CCC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435935 92276 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 466 6 0 2 6.7 CCC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118576974 156633 0 None -10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4075688 156633 0 None -10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
156705100 181657 0 None 4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783601 181657 0 None 4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
3223370 109433 2 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234546 109433 2 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
90654580 109447 0 None 4 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234561 109447 0 None 4 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
90644457 111723 0 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290734 111723 0 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
90654588 109455 0 None 1 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234569 109455 0 None 1 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
164611903 184547 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 529 4 2 3 7.9 CCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4856750 184547 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 529 4 2 3 7.9 CCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
164621055 185345 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 4 7.0 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4869294 185345 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 4 7.0 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
11656002 82585 23 None -61 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2181247 82585 23 None -61 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654581 109448 0 None -7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234562 109448 0 None -7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
45483949 3512 28 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
7048 3512 28 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
CHEMBL567640 3512 28 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
118735267 118315 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421903 118315 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
164609009 183832 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 570 5 2 5 7.4 CO/N=C(/C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4846185 183832 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 570 5 2 5 7.4 CO/N=C(/C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
1434463 157191 5 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
CHEMBL4082345 157191 5 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
45483949 3512 28 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
7048 3512 28 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
CHEMBL567640 3512 28 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
11165617 158319 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL409511 158319 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118464622 158313 0 None 26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4095058 158313 0 None 26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118464720 156550 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 598 6 0 4 9.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C(F)(F)F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4074596 156550 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 598 6 0 4 9.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C(F)(F)F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
76332905 105536 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 6 3.2 COc1cccc(-c2nnn(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132972 105536 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 6 3.2 COc1cccc(-c2nnn(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
77845211 111714 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 6 1 6 5.5 O=C(O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290725 111714 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 6 1 6 5.5 O=C(O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
221493 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
3096 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
609 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
CHEMBL205596 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
DB02659 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
221493 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
3096 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
609 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
CHEMBL205596 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
DB02659 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
221493 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
3096 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
609 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
CHEMBL205596 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
DB02659 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
221493 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
3096 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
609 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
CHEMBL205596 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
DB02659 906 85 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
10140 159778 55 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 465 6 5 5 2.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL411070 159778 55 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 465 6 5 5 2.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
156705083 182504 0 None 10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794523 182504 0 None 10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71541723 86848 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
CHEMBL2331647 86848 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
156705119 182522 0 None -29 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794753 182522 0 None -29 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654576 109443 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
CHEMBL3234557 109443 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
156705083 182504 0 None -10 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794523 182504 0 None -10 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
130361963 170571 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 387 4 1 3 5.6 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC#N)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4458539 170571 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 387 4 1 3 5.6 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC#N)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
71561883 87205 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336235 87205 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
90654588 109455 0 None -1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234569 109455 0 None -1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654595 109469 0 None -7 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234582 109469 0 None -7 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
89501434 160838 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 542 11 0 6 6.9 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4126485 160838 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 542 11 0 6 6.9 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
44427761 92782 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 4 3 3 5.0 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1[C@@H](C)[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL244784 92782 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 4 3 3 5.0 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1[C@@H](C)[C@H]3O)C(=O)O 10.1021/jm070633p
90654582 109449 0 None -6 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234563 109449 0 None -6 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654569 109435 1 None -2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234549 109435 1 None -2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
58043589 91162 0 None 8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 91162 0 None 8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
118464804 155990 0 None -4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4068168 155990 0 None -4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71561618 87197 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 457 4 0 4 6.5 Cc1ccccc1C1CCCCN1C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336226 87197 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 457 4 0 4 6.5 Cc1ccccc1C1CCCCN1C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
90654575 109442 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
CHEMBL3234556 109442 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
118735266 118314 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421902 118314 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
90644460 111717 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 8 1 9 4.6 CCOC(=O)CNC(=O)c1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290728 111717 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 8 1 9 4.6 CCOC(=O)CNC(=O)c1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118586281 158005 0 None 7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4091702 158005 0 None 7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
46232736 199613 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
CHEMBL604131 199613 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
46232736 199613 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL604131 199613 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71599441 162989 0 None -109 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 162989 0 None -109 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
156705091 181615 0 None -20 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783037 181615 0 None -20 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
64945 58667 73 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.1 C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)O)CC[C@H]1C 10.1021/jm900872z
CHEMBL169 58667 73 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.1 C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)O)CC[C@H]1C 10.1021/jm900872z
156705115 181527 0 None 3 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4782069 181527 0 None 3 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
447718 97035 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCCC[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270311 97035 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCCC[C@H]1C[C@H]3O 10.1021/jm7015864
71540076 86852 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331651 86852 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
71561365 87183 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336210 87183 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71540073 86849 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hrAgonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hr
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 86849 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hrAgonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hr
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626558 111698 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1cccc2[nH]ccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290709 111698 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1cccc2[nH]ccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71561369 87187 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cc(Cl)ccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336214 87187 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cc(Cl)ccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
11281589 117162 10 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 420 5 3 3 5.1 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401355 117162 10 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 420 5 3 3 5.1 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
71561365 87183 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336210 87183 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561614 87189 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336216 87189 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71626560 111701 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290712 111701 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654600 109507 0 None -8 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 109507 0 None -8 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
71457418 82563 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
CHEMBL2181225 82563 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
46233021 199120 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 404 3 0 3 5.3 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Br)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600827 199120 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 404 3 0 3 5.3 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Br)cc1 10.1016/j.bmcl.2010.01.003
118093575 163065 1 None 6 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203848 163065 1 None 6 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118104397 163610 0 None 15 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
CHEMBL4210547 163610 0 None 15 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
73352466 92265 0 None -4 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435924 92265 0 None -4 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
447715 195242 61 None 12 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL566315 195242 61 None 12 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
71626229 118313 0 None -2 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421901 118313 0 None -2 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
164628742 185978 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 595 4 2 3 9.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6ccc(F)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4878269 185978 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 595 4 2 3 9.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6ccc(F)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118464786 156077 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4069164 156077 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1Cl 10.1021/acsmedchemlett.7b00116
24969872 17472 0 None 10 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
CHEMBL1258423 17472 0 None 10 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
71540075 86851 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331650 86851 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311618 82588 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181251 82588 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
118586298 157470 0 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4085664 157470 0 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
10133 895 70 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
145714624 895 70 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
4361 895 70 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
608 895 70 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
CHEMBL240597 895 70 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
DB06777 895 70 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
71541719 86847 1 None 194 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 86847 1 None 194 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
44605616 196608 62 None 28 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 196608 62 None 28 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
118093402 163657 0 None 1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211041 163657 0 None 1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232529 199159 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601233 199159 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118104385 163019 0 None 5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203321 163019 0 None 5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118464806 158499 0 None -34 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4097059 158499 0 None -34 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71661222 163934 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4214506 163934 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660822 164202 0 None -5 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217961 164202 0 None -5 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71561504 87193 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336222 87193 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
71626697 111700 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290711 111700 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90644456 111720 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290731 111720 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
156705098 182802 1 None 12 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4798091 182802 1 None 12 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
137634612 155562 0 None 35 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4063237 155562 0 None 35 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
145955827 162120 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 504 5 4 4 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)N3CC[C@H](O)C3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4170310 162120 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 504 5 4 4 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)N3CC[C@H](O)C3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
71461057 82583 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 403 5 0 5 4.9 COc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181244 82583 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 403 5 0 5 4.9 COc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
76322065 105531 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 6 3.8 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132968 105531 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 6 3.8 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
90654573 109440 0 None -1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
CHEMBL3234554 109440 0 None -1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
90654565 109463 0 None 1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234576 109463 0 None 1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
136166950 91156 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 91156 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
130361811 155838 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4066443 155838 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
71626491 111699 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2cc[nH]c2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290710 111699 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2cc[nH]c2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71462788 82571 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 417 3 0 5 5.3 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/jm301071h
CHEMBL2181232 82571 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 417 3 0 5 5.3 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/jm301071h
9838552 191484 50 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1 10.1021/acs.jmedchem.1c01078
CHEMBL5202995 191484 50 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1 10.1021/acs.jmedchem.1c01078
45483949 3512 28 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
7048 3512 28 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
CHEMBL567640 3512 28 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
137641119 156455 0 None -28 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4073356 156455 0 None -28 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
77845060 111713 0 None -7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL3290724 111713 0 None -7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
1434463 157191 5 None -1 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
CHEMBL4082345 157191 5 None -1 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
71626489 111689 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290700 111689 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654581 109448 0 None 7 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234562 109448 0 None 7 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654592 109460 0 None 2 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234573 109460 0 None 2 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118577298 160427 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 160427 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 160427 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 160427 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
66739980 138922 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL3794175 138922 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
89501851 160984 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 540 11 0 6 7.3 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(Cl)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4128655 160984 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 540 11 0 6 7.3 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(Cl)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
164611905 184548 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 515 3 2 3 7.5 CNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4856752 184548 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 515 3 2 3 7.5 CNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
168277662 189569 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 7 0 3 5.2 CCC(C)COc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5173976 189569 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 7 0 3 5.2 CCC(C)COc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
58043414 91171 0 None 38 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 91171 0 None 38 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
90654586 109453 0 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234567 109453 0 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
71626833 118309 0 None -1 2 Mouse 4.8 pEC50 = 4.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421897 118309 0 None -1 2 Mouse 4.8 pEC50 = 4.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
101882379 113735 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 420 6 3 3 5.3 C[C@H](CCCCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
CHEMBL3330019 113735 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 420 6 3 3 5.3 C[C@H](CCCCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
52905075 158201 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL4093987 158201 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
164617191 183920 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 613 6 4 4 7.1 CC(C)[C@@H]1CC[C@]2(NC(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4847526 183920 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 613 6 4 4 7.1 CC(C)[C@@H]1CC[C@]2(NC(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
164608751 183861 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 567 4 3 4 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6cc[nH]n6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4846632 183861 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 567 4 3 4 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6cc[nH]n6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
10790510 100789 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 469 2 2 3 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL296302 100789 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 469 2 2 3 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
155669596 180077 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4755237 180077 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118577298 160427 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 160427 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 160427 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 160427 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
121355127 162249 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 444 5 3 5 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nn[nH]n3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4172477 162249 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 444 5 3 5 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nn[nH]n3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
118709776 113052 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 2 3 4.2 O=C(Nc1cc(Cl)ccc1Cl)C1(C(=O)N2CCNc3ccccc32)CC1 10.1016/j.bmcl.2014.07.026
CHEMBL3321849 113052 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 2 3 4.2 O=C(Nc1cc(Cl)ccc1Cl)C1(C(=O)N2CCNc3ccccc32)CC1 10.1016/j.bmcl.2014.07.026
90644449 111694 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2cccnc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290705 111694 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2cccnc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137646061 157261 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083324 157261 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71561885 87207 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336237 87207 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
90644444 111724 0 None 4 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290735 111724 0 None 4 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90654597 109504 0 None -17 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234868 109504 0 None -17 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90644458 111721 0 None 1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290732 111721 0 None 1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
53311869 82578 0 None -3 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181239 82578 0 None -3 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
164628005 185894 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 4 7.2 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/acs.jmedchem.1c00851
CHEMBL4877060 185894 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 4 7.2 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/acs.jmedchem.1c00851
118586282 158996 0 None 23 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4102610 158996 0 None 23 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
168270223 189462 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 8 0 3 5.4 CCCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5172427 189462 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 8 0 3 5.4 CCCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
6013 141326 49 None -575 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL386630 141326 49 None -575 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
137651596 156574 0 None - 1 Mouse 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 546 6 0 4 8.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(Cl)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4075062 156574 0 None - 1 Mouse 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 546 6 0 4 8.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(Cl)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118464638 158976 0 None -15 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102357 158976 0 None -15 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
11656002 82585 23 None 61 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2181247 82585 23 None 61 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654568 109466 0 None -4 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234579 109466 0 None -4 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
46232361 198812 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 3 0 3 5.2 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1C 10.1016/j.bmcl.2010.01.003
CHEMBL598743 198812 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 3 0 3 5.2 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1C 10.1016/j.bmcl.2010.01.003
46232414 198918 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599328 198918 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
46232598 199263 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601882 199263 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232660 199569 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603921 199569 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
90654583 109450 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234564 109450 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
130361919 156554 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC(=O)N4CCCC4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4074652 156554 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC(=O)N4CCCC4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
387316 66421 45 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL185878 66421 45 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
126700763 157895 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 557 11 1 7 6.4 COc1ccc(N(C)c2c(CCC(=O)O)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090586 157895 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 557 11 1 7 6.4 COc1ccc(N(C)c2c(CCC(=O)O)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118103740 162990 0 None -25 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
CHEMBL4202994 162990 0 None -25 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
71661220 163058 0 None -1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203777 163058 0 None -1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093390 163307 0 None -19 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4206832 163307 0 None -19 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71661186 163719 0 None -3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4211892 163719 0 None -3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093420 163982 0 None 1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4215113 163982 0 None 1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
155528730 170803 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 469 5 3 5 3.5 C[C@H](CCC(=O)NS(C)(=O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4461961 170803 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 469 5 3 5 3.5 C[C@H](CCC(=O)NS(C)(=O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118093418 163532 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4209597 163532 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232986 199096 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL600624 199096 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1Cl 10.1016/j.bmcl.2010.01.003
71661222 163934 0 None -1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4214506 163934 0 None -1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
44605616 196608 62 None -28 2 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 196608 62 None -28 2 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
90654584 109451 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
CHEMBL3234565 109451 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
71540078 86854 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331653 86854 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71455634 82565 0 None -4 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181227 82565 0 None -4 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
90654566 109464 0 None 1 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234577 109464 0 None 1 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654595 109469 0 None 7 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234582 109469 0 None 7 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654596 109470 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234583 109470 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90654599 109506 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234870 109506 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
118576958 157847 0 None 17 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090147 157847 0 None 17 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
156705090 181115 0 None 54 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4776876 181115 0 None 54 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
76322064 105528 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 370 5 0 5 3.8 CCc1nnn(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL3132965 105528 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 370 5 0 5 3.8 CCc1nnn(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71462786 82566 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
CHEMBL2181228 82566 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
71540073 86849 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
CHEMBL2331648 86849 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
145962358 160882 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4127302 160882 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
71540073 86849 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 86849 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71461054 82569 0 None -3 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181230 82569 0 None -3 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
71561882 87204 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336234 87204 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
71626699 111705 0 None -5 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290716 111705 0 None -5 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71541719 86847 1 None 194 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 86847 1 None 194 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
118103679 163385 0 None 39 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4207707 163385 0 None 39 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118103737 164268 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 738 12 3 7 5.1 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N1CCN(CP(=O)(O)O)CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4218746 164268 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 738 12 3 7 5.1 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N1CCN(CP(=O)(O)O)CC1 10.1021/acs.jmedchem.8b00308
71540076 86852 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331651 86852 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
156705112 182272 0 None 15 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4791709 182272 0 None 15 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71450252 82579 0 None 10 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181240 82579 0 None 10 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
71540175 86856 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331655 86856 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311869 82578 0 None 3 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL2181239 82578 0 None 3 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71452080 82593 0 None 10 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181256 82593 0 None 10 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
118709771 113016 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 429 3 2 6 4.3 CN1CCN(C(=O)c2cnc(O)nc2Nc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321758 113016 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 429 3 2 6 4.3 CN1CCN(C(=O)c2cnc(O)nc2Nc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
71452078 82589 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 428 4 0 5 5.1 CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181252 82589 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 428 4 0 5 5.1 CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
90654563 109461 0 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234574 109461 0 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576930 158257 0 None -25 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
CHEMBL4094487 158257 0 None -25 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
90655904 112296 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
CHEMBL3260994 112296 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
CHEMBL3306811 112296 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
56601732 91159 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 91159 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
168276623 189807 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 295 4 2 4 3.2 O=C(O)c1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5177797 189807 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 295 4 2 4 3.2 O=C(O)c1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
118735267 118315 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421903 118315 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
447715 195242 61 None 12 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
CHEMBL566315 195242 61 None 12 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
73350992 92263 0 None 10 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435921 92263 0 None 10 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73350992 92263 0 None -10 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435921 92263 0 None -10 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
118464724 158906 0 None -61 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4101442 158906 0 None -61 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
137651232 156814 0 None 20 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4077972 156814 0 None 20 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
137629931 160457 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4064764 160457 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116312 160457 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
44627311 195596 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL568584 195596 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
156705098 182802 1 None -12 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4798091 182802 1 None -12 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
66740913 158097 0 None 22 2 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4092629 158097 0 None 22 2 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
89501422 161070 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(C#N)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4130025 161070 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(C#N)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
118464747 157777 0 None 4 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4089352 157777 0 None 4 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
73357025 92272 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 568 7 0 3 7.3 O=S(=O)(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435931 92272 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 568 7 0 3 7.3 O=S(=O)(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
90654577 109444 0 None -17 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234558 109444 0 None -17 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
156705085 182395 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4793377 182395 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
164628559 185954 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 1 3 8.3 CCN(C)C(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4877942 185954 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 1 3 8.3 CCN(C)C(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71718878 87208 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336238 87208 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
71718878 87208 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
CHEMBL2336238 87208 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
118464713 158738 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 516 6 0 5 6.9 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4099616 158738 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 516 6 0 5 6.9 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
71541722 86846 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
CHEMBL2331645 86846 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
77845060 111713 0 None 7 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL3290724 111713 0 None 7 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
44337790 6993 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 2 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 10.1021/jm900872z
CHEMBL108505 6993 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 2 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 10.1021/jm900872z
90654572 109439 0 None 1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
CHEMBL3234553 109439 0 None 1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
137634963 155328 0 None -21 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4060463 155328 0 None -21 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
5284061 16780 10 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1253814 16780 10 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
66737876 117158 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 390 4 2 2 5.8 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401351 117158 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 390 4 2 2 5.8 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
90654578 109445 0 None 3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234559 109445 0 None 3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
155534242 171347 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1nnc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)o1 10.1021/acs.jmedchem.9b00770
CHEMBL4470072 171347 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1nnc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)o1 10.1021/acs.jmedchem.9b00770
10494 2860 77 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
3306 2860 77 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
CHEMBL168 2860 77 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
156019954 177411 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 385 3 2 3 5.1 C=C[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4646264 177411 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 385 3 2 3 5.1 C=C[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
164613461 184397 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 607 5 2 4 9.4 COc1ccc(NC(=O)O[C@@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@]34C)C2(C)C)cc1 10.1021/acs.jmedchem.1c00851
CHEMBL4854339 184397 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 607 5 2 4 9.4 COc1ccc(NC(=O)O[C@@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@]34C)C2(C)C)cc1 10.1021/acs.jmedchem.1c00851
44457460 95656 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](F)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL260314 95656 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](F)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
44605617 196632 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL576138 196632 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
71452076 82570 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 454 4 0 5 5.6 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181231 82570 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 454 4 0 5 5.6 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
90654582 109449 0 None 6 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234563 109449 0 None 6 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
156705093 181298 0 None -25 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4779084 181298 0 None -25 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
162665892 181733 0 None 16 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4784355 181733 0 None 16 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
73350995 92283 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435943 92283 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
137630517 160511 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083747 160511 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116717 160511 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
387316 66421 45 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
CHEMBL185878 66421 45 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
168281036 190352 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 281 4 2 4 3.0 OCc1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5185938 190352 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 281 4 2 4 3.0 OCc1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
71561366 87184 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336211 87184 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
44457491 95935 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 481 7 2 3 5.7 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL261826 95935 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 481 7 2 3 5.7 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
118576918 160572 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4078612 160572 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117224 160572 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
31401 47830 78 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
CHEMBL1551 47830 78 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
90644446 111711 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290722 111711 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
44605617 196632 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
CHEMBL576138 196632 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
118577239 160424 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060410 160424 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116055 160424 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71459275 82574 0 None -7 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181235 82574 0 None -7 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
145956445 161524 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 505 6 3 5 5.2 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)O[C@H]3CCOC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4160849 161524 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 505 6 3 5 5.2 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)O[C@H]3CCOC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
145177795 161763 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 5 4 4 3.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4164682 161763 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 5 4 4 3.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
71626422 111703 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2cc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)ccc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290714 111703 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2cc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)ccc12 10.1016/j.ejmech.2014.05.031
119046 97075 31 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL270516 97075 31 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71541723 86848 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
CHEMBL2331647 86848 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
134494 159186 17 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL410494 159186 17 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
5284305 113732 1 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 364 3 3 3 4.0 C[C@H](CCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
CHEMBL3329940 113732 1 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 364 3 3 3 4.0 C[C@H](CCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
137636348 155312 0 None 12 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4060315 155312 0 None 12 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71626556 111696 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290707 111696 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90644458 111721 0 None -1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290732 111721 0 None -1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
90654599 109506 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234870 109506 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
118103698 163109 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4204655 163109 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660821 163165 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4205214 163165 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093557 164096 0 None -3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4216682 164096 0 None -3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660821 163165 0 None -1 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4205214 163165 0 None -1 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
145972818 164079 0 None 3 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
CHEMBL4216361 164079 0 None 3 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
164617636 184758 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 5 1 4 7.4 COCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4860100 184758 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 5 1 4 7.4 COCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
44457471 97580 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3F 10.1021/jm7015864
CHEMBL273087 97580 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3F 10.1021/jm7015864
5059 204628 37 None -2 3 Human 5.6 pEC50 = 5.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 335 8 1 3 5.4 CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL8747 204628 37 None -2 3 Human 5.6 pEC50 = 5.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 335 8 1 3 5.4 CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
10873253 76827 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
CHEMBL2062552 76827 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
CHEMBL2079119 76827 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
118735268 118316 0 None -2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421904 118316 0 None -2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
45483949 3512 28 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
7048 3512 28 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
CHEMBL567640 3512 28 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
118104397 163610 0 None -15 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
CHEMBL4210547 163610 0 None -15 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
118093510 163623 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4210686 163623 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71660823 163817 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213036 163817 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118104381 163972 0 None -7 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
CHEMBL4215045 163972 0 None -7 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
46233055 199029 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(Cl)ccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL600021 199029 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(Cl)ccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
118093402 163657 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211041 163657 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118464662 158581 0 None -22 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4097990 158581 0 None -22 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
71661223 163870 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213705 163870 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232983 199194 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1F 10.1016/j.bmcl.2010.01.003
CHEMBL601448 199194 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1F 10.1016/j.bmcl.2010.01.003
46233053 199430 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL603107 199430 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
46232359 199681 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL604520 199681 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2010.01.003
118093511 163462 0 None 3 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4208655 163462 0 None 3 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
118586278 159175 0 None -50 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104779 159175 0 None -50 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
137630592 160539 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068186 160539 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116953 160539 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
44427764 92832 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL245001 92832 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
71541720 86844 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
CHEMBL2331643 86844 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
156705111 182338 0 None 2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4792593 182338 0 None 2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654593 109467 0 None -2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234580 109467 0 None -2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
71455632 82561 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181223 82561 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
164620346 185622 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 3 8.5 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4873169 185622 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 3 8.5 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
164626982 185714 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 5 2 3 8.3 CCCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4874555 185714 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 5 2 3 8.3 CCCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
164627955 185808 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 516 4 2 4 6.7 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)CO)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4875868 185808 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 516 4 2 4 6.7 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)CO)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
73350994 92282 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435942 92282 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118577298 160427 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 160427 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 160427 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 160427 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
137656785 159127 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 510 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4104148 159127 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 510 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
164623929 185649 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4873587 185649 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
247732 95690 22 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL260526 95690 22 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
44457504 97074 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 388 5 1 1 7.2 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL270494 97074 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 388 5 1 1 7.2 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
1452577 109436 1 None -4 2 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
CHEMBL3234550 109436 1 None -4 2 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
137657436 159018 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4ccc(F)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102817 159018 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4ccc(F)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
156017547 177203 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 359 2 2 3 4.5 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4643260 177203 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 359 2 2 3 4.5 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
71459273 82559 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181221 82559 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
5283906 159567 29 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 2 5.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL410893 159567 29 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 2 5.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
164626661 186002 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 614 6 3 5 7.5 CC(C)[C@@H]1CC[C@]2(NC(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4878597 186002 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 614 6 3 5 7.5 CC(C)[C@@H]1CC[C@]2(NC(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
90654565 109463 0 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234576 109463 0 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
136166955 91166 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 91166 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
5994 4558 85 None 3 4 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL103 4558 85 None 3 4 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
155534680 171372 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 431 3 2 3 4.6 C[C@H](CC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4470499 171372 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 431 3 2 3 4.6 C[C@H](CC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464823 158051 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 496 6 0 4 7.6 COc1cccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)c1 10.1021/acsmedchemlett.7b00116
CHEMBL4092168 158051 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 496 6 0 4 7.6 COc1cccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)c1 10.1021/acsmedchemlett.7b00116
156011298 176802 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 3 2 3 5.6 CC(C)[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4638053 176802 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 3 2 3 5.6 CC(C)[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
71626492 111695 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290706 111695 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
145949879 162228 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 6 3 4 5.4 CCOC(=O)NCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1[C@@H](CC)[C@H]3O 10.1021/acsmedchemlett.7b00318
CHEMBL4172216 162228 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 6 3 4 5.4 CCOC(=O)NCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1[C@@H](CC)[C@H]3O 10.1021/acsmedchemlett.7b00318
1452520 109434 1 None 1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234547 109434 1 None 1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
17755103 197136 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL583611 197136 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1016/j.bmc.2015.01.048
164622322 185245 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 569 4 2 3 8.8 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4867540 185245 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 569 4 2 3 8.8 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
137660218 158673 0 None 16 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4098862 158673 0 None 16 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92810 156756 55 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 316 1 0 2 4.8 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL407717 156756 55 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 316 1 0 2 4.8 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
439763 157569 18 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL408701 157569 18 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
136166859 91163 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 91163 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
71561499 87190 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 401 4 0 6 4.2 Cc1nn(C)c(Oc2ccccc2C#N)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336217 87190 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 401 4 0 6 4.2 Cc1nn(C)c(Oc2ccccc2C#N)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
11463847 97437 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL272426 97437 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
45483949 3512 28 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
7048 3512 28 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
CHEMBL567640 3512 28 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
118464802 156970 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4079911 156970 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
137630926 160576 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4086239 160576 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4117239 160576 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
387316 66421 45 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
CHEMBL185878 66421 45 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
118576916 157081 0 None -7 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4081298 157081 0 None -7 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71540077 86853 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
CHEMBL2331652 86853 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
90654587 109454 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 109454 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654584 109451 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
CHEMBL3234565 109451 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
90654590 109458 0 None 1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234571 109458 0 None 1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
71459275 82574 0 None 7 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181235 82574 0 None 7 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118093582 163558 0 None 12 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4209927 163558 0 None 12 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
53311869 82578 0 None -3 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL2181239 82578 0 None -3 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71540174 86855 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331654 86855 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311701 113050 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 414 3 0 5 4.7 CN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321845 113050 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 414 3 0 5 4.7 CN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
91758806 113051 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 430 3 1 6 4.4 CN1CCN(C(=O)c2cnc(O)nc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321846 113051 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 430 3 1 6 4.4 CN1CCN(C(=O)c2cnc(O)nc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
46232695 199220 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 CN(C(=O)c1c(-c2ccccc2Cl)noc1C1CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601638 199220 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 CN(C(=O)c1c(-c2ccccc2Cl)noc1C1CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232659 199431 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.5 CCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603112 199431 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.5 CCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103702 163137 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 6 10 2.2 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N[C@@H](C(=O)O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4204919 163137 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 6 10 2.2 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N[C@@H](C(=O)O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145975890 163240 0 None 19 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4206078 163240 0 None 19 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103734 164087 0 None 25 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4216584 164087 0 None 25 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118104386 164129 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 15 4 8 4.2 C[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4217133 164129 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 15 4 8 4.2 C[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
145967535 164230 0 None 15 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4218315 164230 0 None 15 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
90644447 111726 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290737 111726 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
71455636 82590 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 5 0 5 5.5 CCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181253 82590 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 5 0 5 5.5 CCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71452079 82592 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 5 0 5 5.2 C=CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181255 82592 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 5 0 5 5.2 C=CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
90654596 109470 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234583 109470 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
71459273 82559 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181221 82559 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
71452080 82593 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181256 82593 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
164617886 184264 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 501 3 2 3 7.3 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(N)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4852436 184264 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 501 3 2 3 7.3 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(N)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118464664 156636 0 None 2 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4075703 156636 0 None 2 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
156021144 177494 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4647613 177494 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
73350994 92282 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435942 92282 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
14774173 189279 3 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5169385 189279 3 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
101882290 114018 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Activity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayActivity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 446 6 3 4 5.2 COc1ccc(C(=O)Nc2cccc(C(=O)O)c2)c(NC(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm500937v
CHEMBL3335672 114018 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Activity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayActivity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 446 6 3 4 5.2 COc1ccc(C(=O)Nc2cccc(C(=O)O)c2)c(NC(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm500937v
9848818 97438 50 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272427 97438 50 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
118735266 118314 0 None -2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421902 118314 0 None -2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
10133 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
145714624 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
4361 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
608 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
CHEMBL240597 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
DB06777 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
89707030 171192 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 391 4 3 3 3.9 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4467588 171192 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 391 4 3 3 3.9 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464758 155843 0 None -95 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4066466 155843 0 None -95 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
164618147 184773 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 599 6 2 5 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4860380 184773 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 599 6 2 5 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
130361936 169280 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 5 2 5 4.4 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCc4nn[nH]n4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4440213 169280 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 5 2 5 4.4 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCc4nn[nH]n4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
73353940 92273 0 None 27 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435932 92273 0 None 27 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71459274 82560 0 None -3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181222 82560 0 None -3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
71450252 82579 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181240 82579 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
90654563 109461 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234574 109461 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118093535 163883 0 None -5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213844 163883 0 None -5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103672 163887 0 None -31 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213913 163887 0 None -31 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
145974037 164191 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4217797 164191 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44605616 196608 62 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 196608 62 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
44605616 196608 62 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL575966 196608 62 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232628 199123 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600833 199123 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232595 199688 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2C(F)(F)F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604543 199688 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2C(F)(F)F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103700 163420 0 None 3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4208057 163420 0 None 3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103673 163467 1 None 12 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4208726 163467 1 None 12 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118104381 163972 0 None 7 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
CHEMBL4215045 163972 0 None 7 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
137636348 155312 0 None -12 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4060315 155312 0 None -12 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
73353943 92285 0 None 3 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435945 92285 0 None 3 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
64980 203746 5 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 3 6.1 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL80460 203746 5 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 3 6.1 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118464758 155843 0 None 95 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4066466 155843 0 None 95 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
71561617 87196 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccncc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336225 87196 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccncc1 10.1016/j.bmcl.2012.12.076
71453902 82582 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 373 4 0 4 4.9 CN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1 10.1021/jm301071h
CHEMBL2181243 82582 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 373 4 0 4 4.9 CN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1 10.1021/jm301071h
44605617 196632 0 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
CHEMBL576138 196632 0 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
118093484 162959 0 None -31 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202656 162959 0 None -31 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660822 164202 0 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217961 164202 0 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232485 198921 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 410 4 0 4 5.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599347 198921 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 410 4 0 4 5.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
46232596 199370 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2cccc(C(F)(F)F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602691 199370 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2cccc(C(F)(F)F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232486 199842 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 351 3 0 4 4.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C#N)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605356 199842 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 351 3 0 4 4.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C#N)cc1 10.1016/j.bmcl.2010.01.003
46232656 200407 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 6.0 CCCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL608867 200407 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 6.0 CCCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
71660823 163817 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213036 163817 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093420 163982 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4215113 163982 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
5283820 97496 59 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272621 97496 59 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
46232657 199125 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C1CC1 10.1016/j.bmcl.2010.01.003
CHEMBL600835 199125 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C1CC1 10.1016/j.bmcl.2010.01.003
46232698 199156 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 372 2 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCc2cc(Cl)ccc21 10.1016/j.bmcl.2010.01.003
CHEMBL601218 199156 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 372 2 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCc2cc(Cl)ccc21 10.1016/j.bmcl.2010.01.003
723048 199230 20 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 1 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601671 199230 20 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 1 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
44626599 196043 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 573 4 1 4 8.9 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)c6ccccc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571478 196043 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 573 4 1 4 8.9 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)c6ccccc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
71561367 87185 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336212 87185 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
73353941 92274 0 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435933 92274 0 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73357026 92281 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccoc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435941 92281 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccoc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
90654570 109437 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234551 109437 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
441302 97399 64 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL272195 97399 64 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
118464804 155990 0 None 4 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4068168 155990 0 None 4 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
24969872 17472 0 None 10 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
CHEMBL1258423 17472 0 None 10 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
126700765 155952 0 None -8 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4067717 155952 0 None -8 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
90654571 109438 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234552 109438 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
71561754 87202 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2336232 87202 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
155339374 181274 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 569 11 7 8 1.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4778769 181274 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 569 11 7 8 1.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
118464724 158906 0 None 61 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4101442 158906 0 None 61 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
439763 157569 18 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 minsAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 mins
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL408701 157569 18 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 minsAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 mins
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
71626834 118312 0 None 2 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421900 118312 0 None 2 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
10133 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
145714624 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
4361 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
608 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
CHEMBL240597 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
DB06777 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
10133 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
145714624 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
4361 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
608 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
CHEMBL240597 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
DB06777 895 70 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
44627310 197092 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 474 3 3 3 6.1 CC(CO)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL583203 197092 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 474 3 3 3 6.1 CC(CO)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
5881 205113 77 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL90593 205113 77 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
71559936 87181 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 394 4 0 5 4.4 Cc1nn(C)c(Oc2ccccc2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336208 87181 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 394 4 0 5 4.4 Cc1nn(C)c(Oc2ccccc2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
126673445 156994 0 None -47 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4080290 156994 0 None -47 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
155669594 182542 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 394 4 0 4 3.8 O=C(c1cncn1Cc1ccc(F)cc1F)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4795121 182542 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 394 4 0 4 3.8 O=C(c1cncn1Cc1ccc(F)cc1F)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
12310288 158168 37 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL409348 158168 37 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
90644457 111723 0 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290734 111723 0 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
118464680 158102 0 None -46 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4092785 158102 0 None -46 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
45483949 3512 28 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
7048 3512 28 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
CHEMBL567640 3512 28 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
156705120 181281 0 None -41 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4778884 181281 0 None -41 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71559937 87182 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336209 87182 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
73352466 92265 0 None 4 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435924 92265 0 None 4 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90644448 111725 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290736 111725 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
118576935 157395 0 None -43 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4084668 157395 0 None -43 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118576958 157847 0 None -17 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090147 157847 0 None -17 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
89501664 160892 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 566 9 0 4 8.7 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2c(F)cccc2Cl)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
CHEMBL4127444 160892 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 566 9 0 4 8.7 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2c(F)cccc2Cl)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
73355480 92277 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 514 6 0 2 7.6 O=C(c1ccccc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435937 92277 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 514 6 0 2 7.6 O=C(c1ccccc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
1452520 109434 1 None -1 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234547 109434 1 None -1 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
118464718 157693 0 None -36 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4088541 157693 0 None -36 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
155669596 180077 0 None -1 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4755237 180077 0 None -1 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71626832 118307 0 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421894 118307 0 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118464622 158313 0 None -26 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4095058 158313 0 None -26 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71561614 87189 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336216 87189 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
90654567 109465 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234578 109465 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
44427760 92781 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL244783 92781 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
17755103 197136 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/jm901390p
CHEMBL583611 197136 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/jm901390p
136166852 91188 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 91188 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
44457475 95735 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 509 9 2 3 6.5 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL260737 95735 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 509 9 2 3 6.5 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
45483949 3512 28 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
7048 3512 28 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
CHEMBL567640 3512 28 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
31401 47830 78 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1551 47830 78 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
45485277 196046 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 553 4 1 4 8.7 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@](C)(CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)C(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571493 196046 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 553 4 1 4 8.7 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@](C)(CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)C(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118586279 155299 0 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060122 155299 0 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
114611 97210 36 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL271208 97210 36 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
137653533 158205 0 None -48 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4094009 158205 0 None -48 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
155669593 182630 0 None -31 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4796107 182630 0 None -31 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
164612607 184818 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4861151 184818 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
73347897 92266 0 None -6 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435925 92266 0 None -6 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71455635 82580 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 5 4.9 CN(C)c1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181241 82580 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 5 4.9 CN(C)c1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
118464811 156237 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070895 156237 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
5880 204382 37 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL85799 204382 37 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
71541721 86845 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
CHEMBL2331644 86845 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
90644459 111708 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 6 0 7 6.4 CCOC(=O)c1oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290719 111708 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 6 0 7 6.4 CCOC(=O)c1oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
90654592 109460 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234573 109460 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90644453 111710 0 None -7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290721 111710 0 None -7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
90654574 109441 0 None -4 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234555 109441 0 None -4 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
137661039 158930 0 None 21 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4101738 158930 0 None 21 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
164614522 184302 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 598 6 3 4 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4852971 184302 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 598 6 3 4 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
71626765 118306 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421893 118306 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118464620 158356 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 542 7 0 5 8.1 COc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4095497 158356 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 542 7 0 5 8.1 COc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)cc1 10.1021/acsmedchemlett.7b00116
71561370 87188 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336215 87188 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
73349425 92264 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 456 6 1 2 7.2 CCC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435922 92264 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 456 6 1 2 7.2 CCC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
1012 26 81 None -22387 3 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
1013 26 81 None -22387 3 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
1057 26 81 None -22387 3 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
5757 26 81 None -22387 3 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
CHEMBL135 26 81 None -22387 3 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
DB00783 26 81 None -22387 3 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
71453905 82587 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1ncncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181250 82587 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1ncncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
162665892 181733 0 None -16 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4784355 181733 0 None -16 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
12544 47899 26 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL1552 47899 26 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
77845059 111709 0 None -22 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290720 111709 0 None -22 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118093582 163558 0 None -12 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4209927 163558 0 None -12 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145971348 164007 0 None 1 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4215354 164007 0 None 1 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232629 199124 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
CHEMBL600834 199124 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
118103669 163634 0 None - 1 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 1047 28 13 18 -2.1 O=C(NCCCN(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4210783 163634 0 None - 1 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 1047 28 13 18 -2.1 O=C(NCCCN(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
74766512 156893 0 None -3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4079040 156893 0 None -3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71561619 87198 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336227 87198 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71541719 86847 1 None -194 3 Rat 5.4 pEC50 = 5.4 Functional
Agonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 86847 1 None -194 3 Rat 5.4 pEC50 = 5.4 Functional
Agonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
118464639 157604 0 None - 1 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 541 7 0 6 7.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4[N+](=O)[O-])n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4087370 157604 0 None - 1 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 541 7 0 6 7.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4[N+](=O)[O-])n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118103673 163467 1 None -12 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4208726 163467 1 None -12 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118103718 163958 0 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4214838 163958 0 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
46232982 199727 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604751 199727 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46233023 199954 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL605986 199954 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
118093493 163008 0 None -3 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203191 163008 0 None -3 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118093510 163623 0 None -1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4210686 163623 0 None -1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
118093506 164159 0 None 1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217450 164159 0 None 1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
5283932 97204 17 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 3 4.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCC(=O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL271172 97204 17 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 3 4.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCC(=O)C[C@H]1C[C@H]3O 10.1021/jm7015864
71660856 163643 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210879 163643 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
46232487 198715 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 369 4 0 4 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL598120 198715 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 369 4 0 4 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2010.01.003
749179 200848 16 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1 10.1016/j.bmcl.2010.01.003
CHEMBL611676 200848 16 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1 10.1016/j.bmcl.2010.01.003
90654585 109452 0 None 2 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
CHEMBL3234566 109452 0 None 2 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
90654566 109464 0 None -1 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234577 109464 0 None -1 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654564 109462 0 None 1 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234575 109462 0 None 1 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654568 109466 0 None 4 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234579 109466 0 None 4 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654594 109468 0 None 3 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234581 109468 0 None 3 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576999 159146 0 None 17 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104359 159146 0 None 17 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
162657867 180437 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 390 5 0 5 3.5 COc1ccc(N2CCN(C(=O)c3cncn3[C@H](C)c3ccccc3)CC2)cc1 10.1016/j.bmc.2020.115972
CHEMBL4759282 180437 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 390 5 0 5 3.5 COc1ccc(N2CCN(C(=O)c3cncn3[C@H](C)c3ccccc3)CC2)cc1 10.1016/j.bmc.2020.115972
156705119 182522 0 None 29 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794753 182522 0 None 29 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71540075 86851 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331650 86851 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
118586284 155994 0 None 9 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068227 155994 0 None 9 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
71626557 111691 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2ncccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290702 111691 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2ncccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
126700765 155952 0 None 8 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4067717 155952 0 None 8 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
101886309 114400 20 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCO)[C@@H]2[C@@H]1O 10.1021/jm501273r
CHEMBL3342086 114400 20 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCO)[C@@H]2[C@@H]1O 10.1021/jm501273r
91668293 135845 5 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 (unknown origin) assessed as cAMP levelAgonist activity at TGR5 (unknown origin) assessed as cAMP level
ChEMBL 576 9 4 3 7.1 C[C@H](CCC(=O)N[C@H](CC(=O)O)Cc1c[nH]c2ccccc12)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.08.048
CHEMBL3735125 135845 5 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 (unknown origin) assessed as cAMP levelAgonist activity at TGR5 (unknown origin) assessed as cAMP level
ChEMBL 576 9 4 3 7.1 C[C@H](CCC(=O)N[C@H](CC(=O)O)Cc1c[nH]c2ccccc12)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.08.048
73353938 92260 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 512 5 1 3 6.1 O=S(=O)(NCc1c(-c2ccccc2F)ccnc1Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435915 92260 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 512 5 1 3 6.1 O=S(=O)(NCc1c(-c2ccccc2F)ccnc1Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73353942 92279 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 515 6 0 3 7.0 O=C(c1ccncc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435939 92279 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 515 6 0 3 7.0 O=C(c1ccncc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118709773 113049 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 446 4 1 6 5.4 CSc1ncc(C(=O)N2CCNc3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
CHEMBL3321844 113049 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 446 4 1 6 5.4 CSc1ncc(C(=O)N2CCNc3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
71626490 111690 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1ccc2ccccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290701 111690 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1ccc2ccccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
118576916 157081 0 None 7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4081298 157081 0 None 7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
162656549 180362 0 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@@H]2[C@H]([C@@H]3CC[C@H]([C@H](C)CCC(=O)O)[C@@]3(C)C[C@H]2O)[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL4758363 180362 0 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@@H]2[C@H]([C@@H]3CC[C@H]([C@H](C)CCC(=O)O)[C@@]3(C)C[C@H]2O)[C@@H]1O 10.1021/acs.jmedchem.6b01126
44627314 196059 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571592 196059 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
145955411 161836 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 474 6 4 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)NC3CC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4165830 161836 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 474 6 4 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)NC3CC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
137651232 156814 0 None -20 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4077972 156814 0 None -20 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71540077 86853 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
CHEMBL2331652 86853 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
71540175 86856 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331655 86856 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626556 111696 0 None -1 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290707 111696 0 None -1 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654572 109439 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
CHEMBL3234553 109439 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
118586282 158996 0 None -23 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4102610 158996 0 None -23 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118464815 158957 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4102107 158957 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
44427763 96512 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 422 4 4 4 3.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL266356 96512 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 422 4 4 4 3.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
11069533 97579 29 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL273086 97579 29 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118725000 116546 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL3391714 116546 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
156705112 182272 0 None -15 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4791709 182272 0 None -15 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
118577011 156432 0 None 20 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
CHEMBL4073081 156432 0 None 20 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
91972025 155405 0 None -43 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4061329 155405 0 None -43 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
21121407 156082 1 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL406923 156082 1 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
73352462 92187 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 486 6 1 4 5.9 COC(=O)C(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435835 92187 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 486 6 1 4 5.9 COC(=O)C(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654586 109453 0 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234567 109453 0 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
10635 98246 47 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL27769 98246 47 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
137661958 158965 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 562 10 1 7 5.6 COc1ccc(SCc2cnc([S+]([O-])Cc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4102235 158965 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 562 10 1 7 5.6 COc1ccc(SCc2cnc([S+]([O-])Cc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
164620529 185100 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 551 5 2 4 6.7 CNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4865346 185100 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 551 5 2 4 6.7 CNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71461053 82557 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 0 3 6.1 CN(C(=O)c1cnccc1Oc1cc(Cl)ccc1Cl)c1ccccc1Cl 10.1021/jm301071h
CHEMBL2181219 82557 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 0 3 6.1 CN(C(=O)c1cnccc1Oc1cc(Cl)ccc1Cl)c1ccccc1Cl 10.1021/jm301071h
164610027 184138 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 571 3 1 4 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)N6CCOCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4850654 184138 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 571 3 1 4 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)N6CCOCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
44605617 196632 0 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL576138 196632 0 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
73357023 92262 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 428 5 1 2 6.2 Fc1ccccc1-c1ccncc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435919 92262 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 428 5 1 2 6.2 Fc1ccccc1-c1ccncc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
156014273 176634 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 435 3 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](O)(c4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4635505 176634 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 435 3 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](O)(c4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
56602333 91161 0 None 11 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 91161 0 None 11 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
118464806 158499 0 None 34 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4097059 158499 0 None 34 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73350993 92270 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 495 7 0 3 7.4 CCCN(Cc1cnccc1-c1ccccc1F)C(C#N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435929 92270 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 495 7 0 3 7.4 CCCN(Cc1cnccc1-c1ccccc1F)C(C#N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71561615 87194 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336223 87194 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
71452075 82558 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 371 4 0 4 4.5 O=C(c1cnccc1Oc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181220 82558 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 371 4 0 4 4.5 O=C(c1cnccc1Oc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
46232736 199613 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
CHEMBL604131 199613 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
118586284 155994 0 None -9 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068227 155994 0 None -9 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
73355481 92280 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435940 92280 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
66740913 158097 0 None -22 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4092629 158097 0 None -22 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
122844 167364 52 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 454 2 1 2 7.3 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL431525 167364 52 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 454 2 1 2 7.3 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
192254 16911 22 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1254990 16911 22 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
440071 97073 9 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 563 9 3 6 4.3 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OS(=O)(=O)O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL270493 97073 9 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 563 9 3 6 4.3 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OS(=O)(=O)O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
9910920 195452 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL567835 195452 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
53311618 82588 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL2181251 82588 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.bmcl.2014.07.026
71540074 86850 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331649 86850 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
90654591 109459 0 None 1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
CHEMBL3234572 109459 0 None 1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
118464629 155702 0 None - 1 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1cc(C2CCCc3nc(SCc4c(F)cccc4OC)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4064931 155702 0 None - 1 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1cc(C2CCCc3nc(SCc4c(F)cccc4OC)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
11069533 97579 29 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL273086 97579 29 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
71457417 82556 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 4 5.6 CCN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1C 10.1021/jm301071h
CHEMBL2181218 82556 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 4 5.6 CCN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1C 10.1021/jm301071h
5283821 97495 16 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272620 97495 16 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
90654579 109446 0 None -5 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
CHEMBL3234560 109446 0 None -5 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
53311781 82572 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181233 82572 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
71561756 87203 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336233 87203 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
155339365 180416 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 507 11 2 5 4.8 COCCOCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3OC 10.1039/d0md00425a
CHEMBL4759021 180416 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 507 11 2 5 4.8 COCCOCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3OC 10.1039/d0md00425a
118464755 157947 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4091129 157947 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71561500 87191 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 406 5 0 6 4.3 COc1cccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336218 87191 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 406 5 0 6 4.3 COc1cccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c1 10.1016/j.bmcl.2012.12.076
137660218 158673 0 None -16 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4098862 158673 0 None -16 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
6675 84689 35 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 515 7 5 6 2.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL224867 84689 35 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 515 7 5 6 2.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
164611776 185623 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4873170 185623 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118709777 113053 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 403 3 1 3 4.2 CN1CCN(C(=O)C2(C(=O)Nc3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321850 113053 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 403 3 1 3 4.2 CN1CCN(C(=O)C2(C(=O)Nc3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
118586278 159175 0 None 50 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104779 159175 0 None 50 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
90644453 111710 0 None 7 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290721 111710 0 None 7 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71718878 87208 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336238 87208 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
71718878 87208 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
CHEMBL2336238 87208 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
71626488 111702 0 None -3 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290713 111702 0 None -3 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
155339372 172491 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 444 5 1 5 5.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nnc(C)o3)[C@@H]21 10.1021/acs.jmedchem.9b00770
CHEMBL4519596 172491 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 444 5 1 5 5.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nnc(C)o3)[C@@H]21 10.1021/acs.jmedchem.9b00770
118464803 155231 0 None 15 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4059508 155231 0 None 15 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71661185 163247 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206153 163247 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093562 163324 0 None -5 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207005 163324 0 None -5 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71661185 163247 0 None -1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206153 163247 0 None -1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
14650340 66833 1 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 7 0 3 5.0 CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL18775 66833 1 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 7 0 3 5.0 CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
136167006 91170 0 None 6 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 91170 0 None 6 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
73349428 92284 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 522 6 0 3 7.4 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435944 92284 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 522 6 0 3 7.4 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
12113821 195740 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 511 3 1 4 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL569634 195740 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 511 3 1 4 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
611 2286 69 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
9903 2286 69 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
CHEMBL1478 2286 69 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
9910920 195452 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL567835 195452 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
71626228 118310 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421898 118310 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
44605617 196632 0 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 196632 0 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
118103736 163673 0 None 1 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211208 163673 0 None 1 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232531 197759 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccc(F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL591455 197759 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccc(F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232985 199195 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601449 199195 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmcl.2010.01.003
44605615 197084 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1021/jm901434t
CHEMBL583110 197084 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1021/jm901434t
44605615 197084 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL583110 197084 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
46232594 199369 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602690 199369 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
71660856 163643 0 None -1 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210879 163643 0 None -1 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
10479586 105702 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL3138525 105702 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
9848818 97438 50 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL272427 97438 50 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.09.024
118586280 157730 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4088938 157730 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
71691935 172667 8 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 461 4 3 4 4.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4524597 172667 8 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 461 4 3 4 4.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464701 157633 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4087791 157633 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73357024 92267 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435926 92267 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71626697 111700 0 None -3 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290711 111700 0 None -3 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137645502 157104 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4081476 157104 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
145973129 162469 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 459 5 3 5 5.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3cc(O)no3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4175888 162469 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 459 5 3 5 5.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3cc(O)no3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
90644450 111718 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 9 1 9 4.6 CCOC(=O)CNC(=O)Cc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290729 111718 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 9 1 9 4.6 CCOC(=O)CNC(=O)Cc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
73353937 92259 0 None 20 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435914 92259 0 None 20 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
46232736 199613 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL604131 199613 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71626905 118308 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421896 118308 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71461056 82581 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 387 4 0 4 5.2 Cc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181242 82581 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 387 4 0 4 5.2 Cc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
130361940 158748 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 7 3 3 5.3 CCCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4099757 158748 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 7 3 3 5.3 CCCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
115245 95360 36 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 433 6 3 3 4.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL258818 95360 36 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 433 6 3 3 4.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71453904 82586 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1nccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181248 82586 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1nccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
71561368 87186 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336213 87186 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
137656815 159179 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4104842 159179 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
73352467 92269 0 None -8 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435928 92269 0 None -8 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
54586161 60824 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 551 8 3 4 7.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)OC/C=C/c3ccccc3)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
CHEMBL1765565 60824 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 551 8 3 4 7.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)OC/C=C/c3ccccc3)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
45483949 3512 28 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
7048 3512 28 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
CHEMBL567640 3512 28 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
118464805 157244 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.4 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4083189 157244 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.4 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
611 2286 69 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
9903 2286 69 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
CHEMBL1478 2286 69 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
156705115 181527 0 None -3 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4782069 181527 0 None -3 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71541719 86847 1 None -281 3 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 86847 1 None -281 3 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
130361815 169900 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 8 1 5 4.2 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](OC=O)C[C@H]1C[C@H]3OC=O 10.1021/acs.jmedchem.9b00770
CHEMBL4449000 169900 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 8 1 5 4.2 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](OC=O)C[C@H]1C[C@H]3OC=O 10.1021/acs.jmedchem.9b00770
162671787 182250 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 876 23 13 15 -2.2 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4791399 182250 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 876 23 13 15 -2.2 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
155669591 182104 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 376 4 0 4 3.7 O=C(c1cncn1Cc1ccc(F)cc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4789395 182104 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 376 4 0 4 3.7 O=C(c1cncn1Cc1ccc(F)cc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
137646061 157261 0 None 3 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083324 157261 0 None 3 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
137634612 155562 0 None -35 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4063237 155562 0 None -35 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
156018264 177207 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4643368 177207 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
71626905 118308 0 None -1 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421896 118308 0 None -1 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71720725 87209 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336239 87209 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
136167037 91174 0 None -1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 91174 0 None -1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90284086 117161 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 418 5 2 2 6.4 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401354 117161 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 418 5 2 2 6.4 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
611 2286 69 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
9903 2286 69 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
CHEMBL1478 2286 69 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
73352464 92261 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 410 5 1 2 6.1 FC(F)(F)c1cc(CNCc2cnccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435918 92261 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 410 5 1 2 6.1 FC(F)(F)c1cc(CNCc2cnccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
1452577 109436 1 None 4 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
CHEMBL3234550 109436 1 None 4 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
71626229 118313 0 None 2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421901 118313 0 None 2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71626493 111693 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2cccnc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290704 111693 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2cccnc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137641119 156455 0 None 28 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4073356 156455 0 None 28 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92880 95734 12 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 1 3 5.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL260735 95734 12 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 1 3 5.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71461058 82594 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 456 6 0 5 5.8 CCCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181257 82594 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 456 6 0 5 5.8 CCCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
156705100 181657 0 None -4 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783601 181657 0 None -4 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654590 109458 0 None -1 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234571 109458 0 None -1 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
45273910 113047 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 413 3 0 4 5.3 CN1CCN(C(=O)c2cccnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321841 113047 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 413 3 0 4 5.3 CN1CCN(C(=O)c2cccnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
90644455 111722 0 None 1 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290733 111722 0 None 1 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
71453901 82577 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181238 82577 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71450251 82564 23 None -8 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181226 82564 23 None -8 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
118103729 163668 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 676 14 3 7 5.0 O=C(O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4211123 163668 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 676 14 3 7 5.0 O=C(O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
118093535 163883 0 None 5 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213844 163883 0 None 5 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118093557 164096 0 None 3 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4216682 164096 0 None 3 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71561504 87193 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336222 87193 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
155669601 180417 0 None 91 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4759025 180417 0 None 91 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
90654569 109435 1 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234549 109435 1 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
71561755 86841 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2331604 86841 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
71626560 111701 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290712 111701 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
156705111 182338 0 None -2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4792593 182338 0 None -2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
137638975 156321 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 546 10 1 7 6.6 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4071870 156321 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 546 10 1 7 6.6 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92803 166767 26 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 360 4 1 1 6.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL429432 166767 26 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 360 4 1 1 6.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
73347897 92266 0 None 6 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435925 92266 0 None 6 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
10133 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
145714624 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
4361 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
608 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
CHEMBL240597 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
DB06777 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
155669601 180417 0 None -91 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4759025 180417 0 None -91 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
76318386 105532 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132969 105532 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
44457506 156752 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 1 6.8 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL407713 156752 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 1 6.8 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
73352467 92269 0 None 8 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435928 92269 0 None 8 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
155339364 182124 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4789628 182124 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
118464749 158021 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 562 7 0 4 8.4 COc1cc(C2(CF)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4091882 158021 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 562 7 0 4 8.4 COc1cc(C2(CF)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
162646016 178881 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL4740844 178881 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
118464630 158096 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 574 6 0 4 8.3 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Br)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4092628 158096 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 574 6 0 4 8.3 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Br)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
5879 204598 47 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL87285 204598 47 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
44627313 196074 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571735 196074 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
73349426 92268 0 None 12 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435927 92268 0 None 12 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90327488 111712 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 5 1 6 5.9 Cc1c(C(=O)O)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290723 111712 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 5 1 6 5.9 Cc1c(C(=O)O)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
90654591 109459 0 None -1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
CHEMBL3234572 109459 0 None -1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
90654580 109447 0 None -4 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234561 109447 0 None -4 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
118093541 162955 0 None -7 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202603 162955 0 None -7 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660979 162979 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4202908 162979 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
145967535 164230 0 None -15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4218315 164230 0 None -15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
46233054 199028 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)ccc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL600020 199028 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)ccc1Cl 10.1016/j.bmcl.2010.01.003
46232737 199186 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 3 4.8 CCc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601428 199186 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 3 4.8 CCc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232570 199502 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603500 199502 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
71661186 163719 0 None 3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4211892 163719 0 None 3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
145971348 164007 0 None -1 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4215354 164007 0 None -1 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46233020 197657 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590739 197657 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
46232626 197813 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL591927 197813 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232627 199229 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 378 3 0 3 5.4 Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601670 199229 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 378 3 0 3 5.4 Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232984 199728 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(F)c1 10.1016/j.bmcl.2010.01.003
CHEMBL604752 199728 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(F)c1 10.1016/j.bmcl.2010.01.003
71661224 163577 0 None 1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210112 163577 0 None 1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118103718 163958 0 None -1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4214838 163958 0 None -1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44605617 196632 0 None -5 2 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 196632 0 None -5 2 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
46232411 199682 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 5 0 3 5.5 CCCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604524 199682 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 5 0 3 5.5 CCCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
71626555 111692 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2ncccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290703 111692 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2ncccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
58043236 91160 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 91160 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
71561881 87199 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 447 4 0 6 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1nccn1C 10.1016/j.bmcl.2012.12.076
CHEMBL2336228 87199 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 447 4 0 6 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1nccn1C 10.1016/j.bmcl.2012.12.076
71561367 87185 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336212 87185 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
46196449 76842 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2062554 76842 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2079386 76842 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
71626489 111689 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290700 111689 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
77846087 111707 0 None -8 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290718 111707 0 None -8 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71453901 82577 0 None -10 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181238 82577 0 None -10 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
156019635 177405 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4646200 177405 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
89501425 160988 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 539 9 0 5 7.8 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2ccc(C#N)cc2)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
CHEMBL4128688 160988 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 539 9 0 5 7.8 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2ccc(C#N)cc2)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
10133 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
145714624 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
4361 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
608 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
CHEMBL240597 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
DB06777 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
10133 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
145714624 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
4361 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
608 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
CHEMBL240597 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
DB06777 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
10133 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
145714624 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
4361 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
608 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
CHEMBL240597 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
DB06777 895 70 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
77845284 111715 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 7 1 6 5.9 O=C(O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290726 111715 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 7 1 6 5.9 O=C(O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118464815 158957 0 None 6 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4102107 158957 0 None 6 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
118586298 157470 0 None 2 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4085664 157470 0 None 2 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
164620833 184966 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 565 6 2 4 7.0 CCNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4863256 184966 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 565 6 2 4 7.0 CCNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
118464664 156636 0 None -2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4075703 156636 0 None -2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
118464811 156237 0 None 5 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070895 156237 0 None 5 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
611 2286 69 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
9903 2286 69 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
CHEMBL1478 2286 69 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
2733768 160741 23 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL412272 160741 23 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
71461055 82576 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 4 0 4 6.1 CC(C)N1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181237 82576 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 4 0 4 6.1 CC(C)N1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118455251 155806 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4065966 155806 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
156014434 176647 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4635684 176647 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
44479724 195407 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 472 2 2 3 6.3 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/jm900872z
CHEMBL567578 195407 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 472 2 2 3 6.3 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/jm900872z
156705091 181615 0 None 20 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783037 181615 0 None 20 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
126673445 156994 0 None 47 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4080290 156994 0 None 47 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71459276 82575 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181236 82575 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118577298 160427 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 160427 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 160427 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 160427 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
77846087 111707 0 None 8 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290718 111707 0 None 8 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673504 157061 0 None 10 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4081050 157061 0 None 10 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
71561366 87184 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336211 87184 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561884 87206 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336236 87206 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
71459274 82560 0 None 3 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181222 82560 0 None 3 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
46232530 199191 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2cccc(F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601440 199191 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2cccc(F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118093541 162955 0 None 7 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202603 162955 0 None 7 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103740 162990 0 None 25 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
CHEMBL4202994 162990 0 None 25 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
71561882 87204 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336234 87204 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
121322331 162325 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 497 6 3 5 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NS(C)(=O)=O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4173597 162325 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 497 6 3 5 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NS(C)(=O)=O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
15818 114924 23 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL335062 114924 23 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
118576999 159146 0 None -17 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104359 159146 0 None -17 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71453906 82591 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 4 0 5 5.5 CC(C)N1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181254 82591 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 4 0 5 5.5 CC(C)N1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71626832 118307 0 None -2 2 Mouse 4.2 pEC50 = 4.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421894 118307 0 None -2 2 Mouse 4.2 pEC50 = 4.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
90644444 111724 0 None -4 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290735 111724 0 None -4 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90654578 109445 0 None -3 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234559 109445 0 None -3 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
118464680 158102 0 None 46 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4092785 158102 0 None 46 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
90284520 117163 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 434 5 3 3 5.4 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401356 117163 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 434 5 3 3 5.4 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
44457480 157408 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 495 8 2 3 6.1 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL408477 157408 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 495 8 2 3 6.1 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
14650410 189595 11 None -6 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 265 4 1 3 3.3 OCc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5174405 189595 11 None -6 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 265 4 1 3 3.3 OCc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
118464628 157418 0 None - 1 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4cc(F)ccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4084863 157418 0 None - 1 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4cc(F)ccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73346391 92278 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 548 6 0 2 8.3 O=C(c1ccc(Cl)cc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435938 92278 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 548 6 0 2 8.3 O=C(c1ccc(Cl)cc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
71540073 86849 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 86849 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71540073 86849 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
CHEMBL2331648 86849 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
136166936 91158 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 91158 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
137645502 157104 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4081476 157104 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118728411 117160 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 404 5 2 2 6.1 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401353 117160 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 404 5 2 2 6.1 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
118586280 157730 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4088938 157730 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
90654570 109437 0 None -2 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234551 109437 0 None -2 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
447715 195242 61 None 12 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
CHEMBL566315 195242 61 None 12 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
11258221 158318 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL409510 158318 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
126016 96989 8 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 2 5.8 CC1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL270105 96989 8 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 2 5.8 CC1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
90654583 109450 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234564 109450 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
71459276 82575 0 None -10 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181236 82575 0 None -10 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
155339369 182190 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 5 2 3 5.1 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]21 10.1039/d0md00425a
CHEMBL4790399 182190 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 5 2 3 5.1 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]21 10.1039/d0md00425a
137653533 158205 0 None 48 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4094009 158205 0 None 48 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
126673452 160594 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4087611 160594 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117342 160594 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
164613452 184348 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 564 6 1 4 7.9 CCCS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4853647 184348 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 564 6 1 4 7.9 CCCS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
118464803 155231 0 None -15 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4059508 155231 0 None -15 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
44372731 54096 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 362 3 2 2 5.1 CC(CC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL160902 54096 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 362 3 2 2 5.1 CC(CC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
44626704 196044 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 525 4 1 4 8.0 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)CC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571482 196044 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 525 4 1 4 8.0 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)CC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118577093 157481 0 None -8 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4085777 157481 0 None -8 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
118464729 156395 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 532 6 0 5 7.4 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4072719 156395 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 532 6 0 5 7.4 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
90644445 111716 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 8 1 9 4.9 CCOC(=O)CNC(=O)c1oc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290727 111716 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 8 1 9 4.9 CCOC(=O)CNC(=O)c1oc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
71541721 86845 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
CHEMBL2331644 86845 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
156011870 176736 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 427 6 2 3 6.3 C=CCCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4637054 176736 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 427 6 2 3 6.3 C=CCCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
44457500 155221 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 402 6 1 1 7.6 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL405879 155221 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 402 6 1 1 7.6 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
71626228 118310 0 None -1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421898 118310 0 None -1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
44626600 196048 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 551 6 1 4 8.6 C=CCCC(=O)O/N=C1\CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571515 196048 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 551 6 1 4 8.6 C=CCCC(=O)O/N=C1\CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
145975890 163240 0 None -19 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4206078 163240 0 None -19 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103697 163394 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207801 163394 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093476 163540 0 None -39 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209669 163540 0 None -39 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
44605617 196632 0 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 196632 0 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
44605617 196632 0 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL576138 196632 0 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2010.01.003
46232568 199403 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
CHEMBL602892 199403 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
2733768 160741 23 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL412272 160741 23 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
118104385 163019 0 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203321 163019 0 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
89651284 164083 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
CHEMBL4216520 164083 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
118093506 164159 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217450 164159 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232697 197904 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 3 6.8 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
CHEMBL592645 197904 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 3 6.8 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
118103736 163673 0 None -1 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211208 163673 0 None -1 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093511 163462 0 None -3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4208655 163462 0 None -3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
46232528 199321 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 384 4 0 5 4.4 COC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602273 199321 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 384 4 0 5 4.4 COC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46232413 199724 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 382 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604734 199724 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 382 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2010.01.003
90654574 109441 0 None 4 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234555 109441 0 None 4 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
90654564 109462 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234575 109462 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
76318387 105535 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 5 4.9 COc1cccc(-c2noc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132971 105535 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 5 4.9 COc1cccc(-c2noc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
90644455 111722 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290733 111722 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90644456 111720 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290731 111720 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
136167004 91157 3 None 1 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 91157 3 None 1 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
164618838 185194 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 4 1 4 8.4 CCOC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4866697 185194 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 4 1 4 8.4 CCOC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71626834 118312 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421900 118312 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118735265 118311 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421899 118311 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
156705085 182395 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4793377 182395 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
118464738 156161 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 564 6 0 4 8.9 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(Cl)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070183 156161 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 564 6 0 4 8.9 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(Cl)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
90654576 109443 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
CHEMBL3234557 109443 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
90644446 111711 0 None -3 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290722 111711 0 None -3 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673489 156118 0 None 13 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4069569 156118 0 None 13 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
45483949 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
7048 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
CHEMBL567640 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
44605418 195073 15 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL565278 195073 15 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
45483949 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
7048 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
CHEMBL567640 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
73349426 92268 0 None -12 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435927 92268 0 None -12 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
137661039 158930 0 None -21 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4101738 158930 0 None -21 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71540078 86854 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331653 86854 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
164623929 185649 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4873587 185649 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
156705120 181281 0 None 41 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4778884 181281 0 None 41 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
155669600 179186 0 None -87 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4744582 179186 0 None -87 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71541720 86844 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
CHEMBL2331643 86844 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
447715 195242 61 None 12 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL566315 195242 61 None 12 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
130361991 169118 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1noc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)n1 10.1021/acs.jmedchem.9b00770
CHEMBL4437850 169118 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1noc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)n1 10.1021/acs.jmedchem.9b00770
71561619 87198 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336227 87198 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
439763 157569 18 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL408701 157569 18 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
90644447 111726 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290737 111726 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
219833 96947 35 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 320 1 2 2 4.4 C[C@H](O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL269897 96947 35 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 320 1 2 2 4.4 C[C@H](O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
73353940 92273 0 None -27 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435932 92273 0 None -27 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
126673504 157061 0 None -10 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4081050 157061 0 None -10 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
164612114 184037 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 512 3 2 3 7.7 CC(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4849469 184037 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 512 3 2 3 7.7 CC(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
5284055 97112 2 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 4 4 3.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270703 97112 2 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 4 4 3.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
70686470 76841 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2062553 76841 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2079385 76841 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
90654571 109438 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234552 109438 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
136166933 91169 0 None 3 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 91169 0 None 3 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
3223370 109433 2 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234546 109433 2 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
118577011 156432 0 None -20 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
CHEMBL4073081 156432 0 None -20 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
118455249 156144 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4069934 156144 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
2733768 160741 23 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL412272 160741 23 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
73346390 92271 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 533 7 0 4 7.8 N#CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccco1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435930 92271 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 533 7 0 4 7.8 N#CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccco1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
71541722 86846 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
CHEMBL2331645 86846 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
155669600 179186 0 None 87 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4744582 179186 0 None 87 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118576918 160572 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4078612 160572 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117224 160572 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
45483949 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
7048 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
CHEMBL567640 3512 28 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
118586279 155299 0 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060122 155299 0 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118586276 155619 0 None 10 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4063932 155619 0 None 10 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
73355479 92275 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 452 5 0 2 6.3 CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435934 92275 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 452 5 0 2 6.3 CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
73353941 92274 0 None -28 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435933 92274 0 None -28 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90283905 117164 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 402 4 1 3 5.1 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401357 117164 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 402 4 1 3 5.1 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
71561502 87192 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 376 4 0 5 4.3 Cc1nn(C)c(Oc2ccccc2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336220 87192 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 376 4 0 5 4.3 Cc1nn(C)c(Oc2ccccc2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561883 87205 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336235 87205 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
118464747 157777 0 None -4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4089352 157777 0 None -4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
90654575 109442 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
CHEMBL3234556 109442 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
90654579 109446 0 None 5 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
CHEMBL3234560 109446 0 None 5 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
156018124 177306 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 449 4 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](O)(Cc4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4644760 177306 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 449 4 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](O)(Cc4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
137630926 160576 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4086239 160576 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4117239 160576 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
118577093 157481 0 None 8 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4085777 157481 0 None 8 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
118455177 155720 0 None - 1 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4065113 155720 0 None - 1 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
89501618 160996 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 563 11 0 8 5.2 COc1ccc(C(C)(C)c2cnc(S(=O)(=O)CCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4128816 160996 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 563 11 0 8 5.2 COc1ccc(C(C)(C)c2cnc(S(=O)(=O)CCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
118464718 157693 0 None 36 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4088541 157693 0 None 36 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
44427762 92783 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 434 5 3 3 5.4 CC[C@@H]1C2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
CHEMBL244785 92783 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 434 5 3 3 5.4 CC[C@@H]1C2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
45483944 195328 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL566985 195328 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
90654573 109440 0 None 1 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
CHEMBL3234554 109440 0 None 1 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
71561616 87195 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccccn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336224 87195 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccccn1 10.1016/j.bmcl.2012.12.076
118735265 118311 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421899 118311 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
130361906 157422 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 473 6 0 3 6.3 CO[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](OC)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CCC(=O)N1CCCC1 10.1021/acs.jmedchem.9b00770
CHEMBL4084918 157422 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 473 6 0 3 6.3 CO[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](OC)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CCC(=O)N1CCCC1 10.1021/acs.jmedchem.9b00770
137634963 155328 0 None 21 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4060463 155328 0 None 21 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
118586276 155619 0 None -10 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4063932 155619 0 None -10 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
52941357 17408 0 None 7 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1258196 17408 0 None 7 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
52945302 17373 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 360 6 1 4 5.3 COc1ccc2cc(CNCc3ccccc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258081 17373 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 360 6 1 4 5.3 COc1ccc2cc(CNCc3ccccc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52949938 17473 0 None -4 2 Mouse 4.9 pIC50 = 4.9 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258424 17473 0 None -4 2 Mouse 4.9 pIC50 = 4.9 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
17755104 17372 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
CHEMBL1258080 17372 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
52946277 17237 0 None -19 2 Mouse 5.8 pIC50 = 5.8 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257612 17237 0 None -19 2 Mouse 5.8 pIC50 = 5.8 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
17755104 17372 0 None -1 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
CHEMBL1258080 17372 0 None -1 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
52948571 17090 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 437 7 1 5 5.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ncco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257142 17090 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 437 7 1 5 5.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ncco3)nc2c1 10.1016/j.bmcl.2010.08.014
136002656 17196 0 None 18 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257491 17196 0 None 18 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52949938 17473 0 None 4 2 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258424 17473 0 None 4 2 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946791 17275 0 None 1 2 Mouse 6.5 pIC50 = 6.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
CHEMBL1257732 17275 0 None 1 2 Mouse 6.5 pIC50 = 6.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
24969872 17472 0 None -10 2 Mouse 5.5 pIC50 = 5.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258423 17472 0 None -10 2 Mouse 5.5 pIC50 = 5.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
26404327 17438 0 None -38 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258311 17438 0 None -38 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969952 17583 0 None -85 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258758 17583 0 None -85 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
52941356 17407 0 None -4 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258195 17407 0 None -4 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52945144 17545 0 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258645 17545 0 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
52946791 17275 0 None -1 2 Human 6.4 pIC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
CHEMBL1257732 17275 0 None -1 2 Human 6.4 pIC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
42429922 17437 4 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258310 17437 4 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969952 17583 0 None 85 2 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258758 17583 0 None 85 2 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946134 17124 0 None 2 2 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257260 17124 0 None 2 2 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948780 17508 0 None -7 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258530 17508 0 None -7 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
52950002 17546 0 None 16 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258646 17546 0 None 16 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
52945144 17545 0 None 7 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258645 17545 0 None 7 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
52947341 17091 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 6 1 3 6.4 Cc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257143 17091 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 6 1 3 6.4 Cc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948858 17618 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 453 7 1 5 5.5 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3nccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258878 17618 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 453 7 1 5 5.5 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3nccs3)nc2c1 10.1016/j.bmcl.2010.08.014
24969527 17584 0 None -77 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258759 17584 0 None -77 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
136002656 17196 0 None -18 2 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257491 17196 0 None -18 2 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 906 85 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
3096 906 85 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
609 906 85 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
CHEMBL205596 906 85 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
DB02659 906 85 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
52941381 17195 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 422 6 1 3 6.1 Brc1ccc(CCNCc2cc3ccccc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1257490 17195 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 422 6 1 3 6.1 Brc1ccc(CCNCc2cc3ccccc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
42429922 17437 4 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258310 17437 4 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948780 17508 0 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258530 17508 0 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 906 85 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
3096 906 85 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
609 906 85 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
CHEMBL205596 906 85 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
DB02659 906 85 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
52946355 17509 1 None -8 2 Mouse 5.2 pIC50 = 5.2 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258531 17509 1 None -8 2 Mouse 5.2 pIC50 = 5.2 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969872 17472 0 None 10 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258423 17472 0 None 10 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969527 17584 0 None 77 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258759 17584 0 None 77 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
52941296 17123 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 456 6 1 3 6.7 Clc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257259 17123 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 456 6 1 3 6.7 Clc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946355 17509 1 None 8 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258531 17509 1 None 8 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
52950002 17546 0 None -16 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258646 17546 0 None -16 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946277 17237 0 None 19 2 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257612 17237 0 None 19 2 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
52941357 17408 0 None -7 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1258196 17408 0 None -7 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
52941356 17407 0 None 4 2 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258195 17407 0 None 4 2 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946134 17124 0 None -2 2 Mouse 5.0 pIC50 = 5.0 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257260 17124 0 None -2 2 Mouse 5.0 pIC50 = 5.0 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
26404327 17438 0 None 38 2 Human 7.0 pIC50 = 7.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258311 17438 0 None 38 2 Human 7.0 pIC50 = 7.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 906 85 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
3096 906 85 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
609 906 85 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
CHEMBL205596 906 85 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
DB02659 906 85 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
10133 895 70 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
145714624 895 70 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
4361 895 70 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
608 895 70 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
CHEMBL240597 895 70 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
DB06777 895 70 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
31401 47830 78 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C None
CHEMBL1551 47830 78 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C None
222528 1336 77 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
4988 1336 77 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
610 1336 77 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
CHEMBL406393 1336 77 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
DB03619 1336 77 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
447715 195242 61 None 12 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O None
CHEMBL566315 195242 61 None 12 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O None
60166172 977 0 None 79 2 Human 9.4 pEC50 = 9.4 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
9078 977 0 None 79 2 Human 9.4 pEC50 = 9.4 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
60166172 977 0 None -79 2 Mouse 7.5 pEC50 = 7.5 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
9078 977 0 None -79 2 Mouse 7.5 pEC50 = 7.5 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
10198 2015 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
137321169 2015 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
23642339 2015 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
CHEMBL3306873 2015 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
11696 4033 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
156587567 4033 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
11697 956 0 None 134 2 Human 8.2 pEC50 = 8.2 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
156304705 956 0 None 134 2 Human 8.2 pEC50 = 8.2 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
11696 4033 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
156587567 4033 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
11697 956 0 None -134 2 Mouse 6.0 pEC50 = 6.0 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
156304705 956 0 None -134 2 Mouse 6.0 pEC50 = 6.0 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
10494 2860 77 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
3306 2860 77 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
CHEMBL168 2860 77 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
3945 618 85 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
64971 618 85 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
CHEMBL269277 618 85 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
DB12480 618 85 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
45483949 3512 28 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
7048 3512 28 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
CHEMBL567640 3512 28 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
222528 1336 77 None - 1 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
4988 1336 77 None - 1 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
610 1336 77 None - 1 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
CHEMBL406393 1336 77 None - 1 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
DB03619 1336 77 None - 1 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
221493 906 85 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
3096 906 85 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
609 906 85 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
CHEMBL205596 906 85 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
DB02659 906 85 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
10133 895 70 None - 1 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
145714624 895 70 None - 1 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
4361 895 70 None - 1 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
608 895 70 None - 1 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
CHEMBL240597 895 70 None - 1 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
DB06777 895 70 None - 1 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
611 2286 69 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
9903 2286 69 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
CHEMBL1478 2286 69 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
5755 20605 75 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO None
CHEMBL131 20605 75 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO None
93055 215986 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 458 4 2 6 3.5 CC(C)(C)CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C None




Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Affinity)
# tested GPCRs
(Affinity)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
89501446 138859 0 None - 0 Human 10.2 pEC50 = 10.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793436 138859 0 None - 0 Human 10.2 pEC50 = 10.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
89501446 138859 0 None - 0 Mouse 10.2 pEC50 = 10.2 Binding
Agonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793436 138859 0 None - 0 Mouse 10.2 pEC50 = 10.2 Binding
Agonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
89501666 138943 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 572 11 0 8 7.0 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794442 138943 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 572 11 0 8 7.0 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
46195848 82584 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.ejmech.2013.07.050
CHEMBL2181246 82584 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.ejmech.2013.07.050
136239453 91167 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407946 91167 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
447715 195242 61 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml400247k
CHEMBL566315 195242 61 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml400247k
10133 895 70 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
145714624 895 70 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
4361 895 70 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
608 895 70 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
CHEMBL240597 895 70 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
DB06777 895 70 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
136166852 91188 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 91188 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136239453 91167 0 None - 0 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407946 91167 0 None - 0 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
136166933 91169 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 91169 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
136166936 91158 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 91158 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
56602333 91161 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 91161 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
76328184 103728 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 391 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCN)[C@@H]2[C@@H]1O 10.1021/ml400247k
CHEMBL3098607 103728 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 391 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCN)[C@@H]2[C@@H]1O 10.1021/ml400247k
136166852 91188 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 91188 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
58043414 91171 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 91171 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
136166955 91166 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 91166 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
89501608 138914 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 559 11 0 9 6.1 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cncn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794111 138914 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 559 11 0 9 6.1 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cncn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136260512 91168 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407947 91168 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
66739980 138922 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794175 138922 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
45483949 3512 28 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
7048 3512 28 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
CHEMBL567640 3512 28 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
89501521 138882 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793859 138882 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166950 91156 0 None - 0 Mouse 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 91156 0 None - 0 Mouse 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
221493 906 85 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
3096 906 85 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
609 906 85 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
CHEMBL205596 906 85 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
DB02659 906 85 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
90644452 111160 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 336 3 1 4 3.2 CC(=O)c1cc(C(=O)N2CCN(C3CC3)c3ccccc32)ccc1O 10.1016/j.ejmech.2014.05.031
CHEMBL3286440 111160 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 336 3 1 4 3.2 CC(=O)c1cc(C(=O)N2CCN(C3CC3)c3ccccc32)ccc1O 10.1016/j.ejmech.2014.05.031
89501429 138816 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 517 10 0 7 6.4 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793012 138816 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 517 10 0 7 6.4 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136167037 91174 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 91174 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166859 91163 0 None - 0 Mouse 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 91163 0 None - 0 Mouse 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
136166936 91158 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 91158 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166966 91165 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 91165 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
56602333 91161 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 91161 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
136166845 91172 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407952 91172 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166900 91164 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N/O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407938 91164 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N/O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
136167006 91170 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 91170 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136167004 91157 3 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 91157 3 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166841 91175 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407955 91175 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90654587 109454 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 109454 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
58043589 91162 0 None - 0 Mouse 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 91162 0 None - 0 Mouse 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
127029731 138941 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 575 11 0 8 7.6 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-c4nccs4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794424 138941 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 575 11 0 8 7.6 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-c4nccs4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166933 91169 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 91169 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
58043236 91160 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 91160 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
136166845 91172 0 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407952 91172 0 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
89501780 138932 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 492 10 0 6 6.5 COc1ccc(C(C)(C)c2cnc(SCCOc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794293 138932 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 492 10 0 6 6.5 COc1ccc(C(C)(C)c2cnc(SCCOc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136260512 91168 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407947 91168 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
136167004 91157 3 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 91157 3 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166859 91163 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 91163 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
56601732 91159 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 91159 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
90654600 109507 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 109507 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90644454 111727 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 413 5 0 5 4.7 CC(=O)c1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.05.031
CHEMBL3290739 111727 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 413 5 0 5 4.7 CC(=O)c1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.05.031
89501594 138855 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 576 11 0 8 6.9 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793388 138855 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 576 11 0 8 6.9 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166950 91156 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 91156 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
56601732 91159 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 91159 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
136166866 91173 0 None - 0 Mouse 5.2 pEC50 = 5.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407953 91173 0 None - 0 Mouse 5.2 pEC50 = 5.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
58043236 91160 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 91160 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
89501494 138809 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 557 11 0 7 7.3 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3792957 138809 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 557 11 0 7 7.3 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166866 91173 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407953 91173 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166966 91165 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 91165 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
611 2286 69 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
9903 2286 69 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
CHEMBL1478 2286 69 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
136167006 91170 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 91170 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166955 91166 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 91166 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
58043414 91171 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 91171 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
89501844 138837 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 590 11 0 8 7.2 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793168 138837 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 590 11 0 8 7.2 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
58043589 91162 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 91162 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
136166841 91175 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407955 91175 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136167037 91174 0 None - 0 Mouse 7.0 pEC50 = 7.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 91174 0 None - 0 Mouse 7.0 pEC50 = 7.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90654600 109507 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 109507 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
5755 20605 75 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
ChEMBL 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO 10.1021/acsmedchemlett.5b00323
CHEMBL131 20605 75 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
ChEMBL 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO 10.1021/acsmedchemlett.5b00323
90654587 109454 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 109454 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q