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Ligand source activities (1 row/activity)

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	155146067	184014	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184014	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155154170	184155	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184155	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155146047	186005	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186005	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	3238641	31175	35	None	354	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL1402510	31175	35	None	354	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	2566134	68756	10	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	5.0	O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL1923999	68756	10	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	5.0	O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1	nan
	584653	183826	41	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2ccc(Br)cc2)c1	nan
	CHEMBL4846114	183826	41	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2ccc(Br)cc2)c1	nan
	155153910	183831	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	4.8	O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1	nan
	CHEMBL4846170	183831	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	1	2	4.8	O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1	nan
	155145976	183864	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4846676	183864	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1	nan
	155154008	183882	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	368	5	1	3	4.2	N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4846959	183882	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	368	5	1	3	4.2	N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155154202	183897	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	407	5	1	4	3.6	CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4847181	183897	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	407	5	1	4	3.6	CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153982	183907	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	5	1	2	4.5	O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1	nan
	CHEMBL4847374	183907	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	5	1	2	4.5	O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1	nan
	7015981	183964	27	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1	nan
	CHEMBL4848369	183964	27	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1	nan
	155154180	183990	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	6	2	3	3.2	NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4848664	183990	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	6	2	3	3.2	NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	114322379	183999	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4848825	183999	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	155153838	184027	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1cccc(COc2ccc3sccc3c2)c1F	nan
	CHEMBL4849270	184027	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1cccc(COc2ccc3sccc3c2)c1F	nan
	155153758	184053	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	291	4	0	4	3.4	COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1	nan
	CHEMBL4849588	184053	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	291	4	0	4	3.4	COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1	nan
	155153970	184083	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	340	4	1	2	4.4	O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1	nan
	CHEMBL4849913	184083	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	340	4	1	2	4.4	O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1	nan
	155154172	184136	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	CHEMBL4850633	184136	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	155154044	184211	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	415	6	2	3	4.5	CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4851715	184211	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	415	6	2	3	4.5	CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155145940	184421	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	311	3	0	2	4.8	N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4854872	184421	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	311	3	0	2	4.8	N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	84614649	184441	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	5	1	2	3.9	O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1	nan
	CHEMBL4855127	184441	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	5	1	2	3.9	O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1	nan
	155153740	184460	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	325	5	1	3	4.2	Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4855384	184460	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	325	5	1	3	4.2	Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F	nan
	107881084	184473	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F	nan
	CHEMBL4855567	184473	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F	nan
	155154045	184509	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	493	8	3	4	5.1	O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856071	184509	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	493	8	3	4	5.1	O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146040	184531	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	1	1	2	4.3	N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4856356	184531	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	1	1	2	4.3	N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145911	184564	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	4	1	2	4.0	NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4857097	184564	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	4	1	2	4.0	NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	102723930	184565	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl	nan
	CHEMBL4857110	184565	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)cc1Cl	nan
	155154009	184566	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	423	6	2	4	3.5	O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4857124	184566	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	423	6	2	4	3.5	O=C(NCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155153960	184613	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1	nan
	CHEMBL4857656	184613	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)c(Cl)c2)cc(C(F)(F)F)c1	nan
	155153995	184685	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1	nan
	CHEMBL4858920	184685	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccn1	nan
	155153774	184693	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	305	4	1	3	3.6	N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4859063	184693	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	305	4	1	3	3.6	N#Cc1cc(Cl)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	155154005	184699	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3ccsc3c2)c1	nan
	CHEMBL4859171	184699	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3ccsc3c2)c1	nan
	155146005	184701	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	429	7	2	3	4.8	CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4859266	184701	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	429	7	2	3	4.8	CC(C)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	106903220	184726	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	1	3	3.3	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1	nan
	CHEMBL4859510	184726	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	1	3	3.3	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)n1	nan
	155153791	184746	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	293	5	1	3	3.8	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1	nan
	CHEMBL4859833	184746	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	293	5	1	3	3.8	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2)c1	nan
	155154252	184747	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4859840	184747	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	155154021	184759	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	405	5	1	2	6.2	O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4860115	184759	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	405	5	1	2	6.2	O=C(Nc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154007	184876	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	419	6	1	2	5.9	O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861940	184876	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	419	6	1	2	5.9	O=C(NCc1ccccc1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	22682941	184909	2	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1	nan
	CHEMBL4862434	184909	2	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2)c1	nan
	155153807	184964	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3occc3c2)c1	nan
	CHEMBL4863225	184964	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3occc3c2)c1	nan
	155153800	185006	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	3.9	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1	nan
	CHEMBL4863762	185006	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	3.9	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(C(F)(F)F)c1	nan
	43531176	185026	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	281	4	1	2	4.0	NCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4864076	185026	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	281	4	1	2	4.0	NCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	137553505	185035	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	5	1	3	3.9	O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	CHEMBL4864265	185035	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	5	1	3	3.9	O=C(O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	155154133	185082	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	5	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1	nan
	CHEMBL4865044	185082	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	5	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)F)cc2F)c1	nan
	7022231	185146	28	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1cccc(OCc2cccc(C(=O)O)c2)c1	nan
	CHEMBL4866106	185146	28	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1cccc(OCc2cccc(C(=O)O)c2)c1	nan
	113925944	185153	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F	nan
	CHEMBL4866201	185153	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)cc1F	nan
	155153793	185156	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1	nan
	CHEMBL4866223	185156	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2Cl)c1	nan
	29080666	185172	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1	nan
	CHEMBL4866428	185172	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2)c1	nan
	155154248	185188	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4866577	185188	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	155153775	185202	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1	nan
	CHEMBL4866840	185202	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1cc(Cl)ccc1OCc1cccc(-c2nnn[nH]2)c1	nan
	155145950	185251	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	376	5	0	3	5.3	CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4867568	185251	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	376	5	0	3	5.3	CCOC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155153837	185253	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1	nan
	CHEMBL4867604	185253	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	398	4	1	2	5.7	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(F)(F)F)c1	nan
	155146125	185259	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	444	8	3	4	3.0	NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4867684	185259	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	444	8	3	4	3.0	NC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	43092667	185262	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4867744	185262	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	155154000	185278	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4868055	185278	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(C#N)ccc1OCc1cccc(C(=O)O)c1	nan
	155154006	185290	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	7	1	2	5.5	CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4868255	185290	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	7	1	2	5.5	CCCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153812	185332	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3sccc3c2)c1	nan
	CHEMBL4869118	185332	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	284	4	1	3	4.2	O=C(O)c1cccc(COc2ccc3sccc3c2)c1	nan
	155153736	185347	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	5	1	3	4.5	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F	nan
	CHEMBL4869336	185347	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	5	1	3	4.5	O=C(O)c1cccc(COc2ccc(-n3cccc3)cc2Cl)c1F	nan
	155154048	185348	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	516	8	3	3	5.8	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4869352	185348	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	516	8	3	3	5.8	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153773	185377	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	4	2.8	Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O	nan
	CHEMBL4869694	185377	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	4	2.8	Cc1c(OCc2cccc(C(=O)O)c2)ccc2c1OCC2=O	nan
	155154141	185446	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	411	5	1	4	5.6	Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1	nan
	CHEMBL4870727	185446	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	411	5	1	4	5.6	Cc1nc(-c2cc(COc3ccc(C(F)(F)F)cc3Cl)cc(C(=O)O)c2)co1	nan
	155154020	185462	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	2	3	4.1	O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4870998	185462	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	2	3	4.1	O=C(NCCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154205	185488	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	6	2	3	3.7	O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871418	185488	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	6	2	3	3.7	O=C(NCCO)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154075	185535	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871892	185535	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153810	185543	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	343	4	1	2	4.3	CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4872055	185543	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	343	4	1	2	4.3	CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153994	185560	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	6	1	3	3.6	O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1	nan
	CHEMBL4872342	185560	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	6	1	3	3.6	O=C(O)c1cccc(COc2ccc(OC(F)F)cc2)c1	nan
	155154215	185587	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	458	9	3	4	3.4	NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4872646	185587	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	458	9	3	4	3.4	NC(=O)CC[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155154082	185593	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	0	3	3.2	COC(=O)c1cccc(COc2cccc(F)c2)c1	nan
	CHEMBL4872725	185593	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	0	3	3.2	COC(=O)c1cccc(COc2cccc(F)c2)c1	nan
	890775	185618	33	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4873123	185618	33	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	258	5	1	3	3.0	COc1ccccc1OCc1cccc(C(=O)O)c1	nan
	584777	185638	43	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	262	4	1	2	3.6	O=C(O)c1cccc(COc2ccc(Cl)cc2)c1	nan
	CHEMBL4873423	185638	43	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	262	4	1	2	3.6	O=C(O)c1cccc(COc2ccc(Cl)cc2)c1	nan
	155154016	185663	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	371	5	1	2	5.1	CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4873773	185663	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	371	5	1	2	5.1	CC(C)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153999	185677	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4873923	185677	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1	nan
	155146134	185678	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1	nan
	CHEMBL4873967	185678	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3ncc[nH]3)c2)c(Cl)c1	nan
	155146091	185725	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	2	4.7	CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4874662	185725	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	2	4.7	CNCc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153987	185765	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	5	1	3	4.7	O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1	nan
	CHEMBL4875200	185765	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	5	1	3	4.7	O=C(O)c1cc(F)cc(COc2ccc(OC(F)(F)F)cc2Cl)c1	nan
	156048221	185769	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	437	7	2	4	3.6	O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	CHEMBL4875343	185769	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	437	7	2	4	3.6	O=C(NCCS(=O)(=O)O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1	nan
	155154219	185772	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	417	7	3	4	3.1	O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4875377	185772	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	417	7	3	4	3.1	O=C(N[C@@H](CO)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	832097	185862	28	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2ccc3ccccc3c2)c1	nan
	CHEMBL4876586	185862	28	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2ccc3ccccc3c2)c1	nan
	155153971	185876	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N	nan
	CHEMBL4876749	185876	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	267	4	1	3	3.1	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1C#N	nan
	155145974	185890	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	2	4.7	N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4876954	185890	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	2	4.7	N#Cc1cc(CCc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	7015989	185891	29	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4877006	185891	29	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(Cl)ccc1OCc1cccc(C(=O)O)c1	nan
	155154019	185903	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	357	5	1	2	4.7	CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4877244	185903	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	357	5	1	2	4.7	CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154178	185904	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	397	5	1	2	5.6	O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4877261	185904	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	397	5	1	2	5.6	O=C(NC1CCCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145948	185982	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	5	1	3	4.7	CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878337	185982	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	373	5	1	3	4.7	CN(C)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153809	185990	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	383	5	1	2	5.2	O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4878428	185990	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	383	5	1	2	5.2	O=C(NC1CCC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153794	186020	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	4	1	2	5.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl	nan
	CHEMBL4879041	186020	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	364	4	1	2	5.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1Cl	nan
	929494	38752	30	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1	nan
	CHEMBL1468323	38752	30	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1	nan
	725872	42335	36	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	286	4	1	3	3.9	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1	nan
	CHEMBL1500515	42335	36	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	286	4	1	3	3.9	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1	nan
	891145	51757	31	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL1587117	51757	31	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155146121	183843	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	358	5	1	2	5.2	CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4846341	183843	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	358	5	1	2	5.2	CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O	nan
	17605178	183945	19	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	246	4	1	2	3.1	O=C(O)c1cccc(COc2ccccc2F)c1	nan
	CHEMBL4847901	183945	19	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	246	4	1	2	3.1	O=C(O)c1cccc(COc2ccccc2F)c1	nan
	7015983	183978	28	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	256	4	1	2	3.6	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1	nan
	CHEMBL4848511	183978	28	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	256	4	1	2	3.6	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1	nan
	155154010	183984	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	425	4	0	3	4.8	O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1	nan
	CHEMBL4848586	183984	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	425	4	0	3	4.8	O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1	nan
	155146163	184200	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	CHEMBL4851598	184200	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	344	4	0	3	4.7	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1	nan
	28542041	184203	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1	nan
	CHEMBL4851647	184203	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2ccccc2C(F)(F)F)c1	nan
	155154015	184227	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	0	3	5.2	COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1	nan
	CHEMBL4851939	184227	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	0	3	5.2	COC1CCN(C(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)CC1	nan
	155154056	184229	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	5	1	2	4.4	O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4851949	184229	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	5	1	2	4.4	O=C(O)c1cccc(COCc2ccc(Cl)cc2Cl)c1	nan
	155154148	184236	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1	nan
	CHEMBL4852032	184236	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1	nan
	22682321	184300	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4852959	184300	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	11472211	184451	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	2	4.6	O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1	nan
	CHEMBL4855304	184451	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	2	4.6	O=C(O)c1cccc(COc2cccc(-c3ccccc3)c2)c1	nan
	15487504	184475	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl	nan
	CHEMBL4855628	184475	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccccc1COc1ccc(Cl)cc1Cl	nan
	116688442	184523	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2cccc(Cl)c2F)c1	nan
	CHEMBL4856288	184523	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2cccc(Cl)c2F)c1	nan
	155154083	184575	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	0	4	4.0	COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	CHEMBL4857218	184575	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	0	4	4.0	COC(=O)c1cccc(COc2ccc(OC(F)(F)F)cc2)c1	nan
	155153972	184642	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	5	1	3	4.1	COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12	nan
	CHEMBL4858105	184642	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	5	1	3	4.1	COc1ccc(OCc2cccc(C(=O)O)c2)c2ccccc12	nan
	155146161	184678	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	CHEMBL4858773	184678	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1c(COc2ccc(Cl)cc2Cl)cccc1C(=O)O	nan
	65339188	184692	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	CHEMBL4859048	184692	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.3	COc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	13013688	184714	4	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	3	1	2	4.5	O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4859370	184714	4	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	3	1	2	4.5	O=C(O)c1cccc(Oc2ccc(Cl)cc2Cl)c1	nan
	155146132	184753	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1	nan
	CHEMBL4860022	184753	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cn2)c1	nan
	155153997	184862	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4861721	184862	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1cc(Cl)cc(Cl)c1OCc1cccc(C(=O)O)c1	nan
	63531317	184879	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4861974	184879	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1ccc(F)c(COc2ccc(Cl)cc2Cl)c1	nan
	24225858	184884	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	5	3.3	COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1	nan
	CHEMBL4862041	184884	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	5	3.3	COC(=O)c1cc(COc2ccc(Cl)cc2Cl)on1	nan
	155153755	184900	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	0	5	3.1	COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4862314	184900	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	312	4	0	5	3.1	COC(=O)c1cncc(COc2ccc(Cl)cc2Cl)n1	nan
	155153805	184960	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	CHEMBL4863173	184960	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	287	4	1	3	3.5	N#Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	155154003	184970	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	318	5	1	2	4.9	Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4863275	184970	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	318	5	1	2	4.9	Cc1cc(-c2ccccc2)ccc1OCc1cccc(C(=O)O)c1	nan
	155154024	185008	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	5	1	2	3.8	O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1	nan
	CHEMBL4863823	185008	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	5	1	2	3.8	O=C(O)c1cccc(COc2ccc(C3CC3)cc2)c1	nan
	17605176	185010	3	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4863854	185010	3	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	272	6	1	3	3.4	CCOc1ccccc1OCc1cccc(C(=O)O)c1	nan
	584738	185032	32	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1	nan
	CHEMBL4864171	185032	32	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)ccc2Cl)c1	nan
	155154171	185049	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2cccc3c2CCC3)c1	nan
	CHEMBL4864441	185049	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	2	3.5	O=C(O)c1cccc(COc2cccc3c2CCC3)c1	nan
	20991272	185203	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1	nan
	CHEMBL4866841	185203	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1ccc(C(C)(C)C)c(OCc2cccc(C(=O)O)c2)c1	nan
	20985043	185207	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1	nan
	CHEMBL4866888	185207	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2cc(Cl)cc(Cl)c2)c1	nan
	721137	185215	46	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1	nan
	CHEMBL4866984	185215	46	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	292	5	1	3	3.6	COc1cc(C(=O)O)ccc1OCc1ccc(Cl)cc1	nan
	155153808	185274	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	3	3.5	O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1	nan
	CHEMBL4868006	185274	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	3	3.5	O=C(O)c1cccc(COc2cccc3c2CCCC3=O)c1	nan
	82096332	185321	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	295	4	2	2	4.3	O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4868865	185321	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	295	4	2	2	4.3	O=C(O)c1cccc(CNc2ccc(Cl)cc2Cl)c1	nan
	155153803	185376	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	372	6	2	3	3.6	NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4869674	185376	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	372	6	2	3	3.6	NCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153783	185424	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	285	5	2	3	2.3	CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL4870496	185424	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	285	5	2	3	2.3	CNC(=O)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155154195	185428	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl	nan
	CHEMBL4870512	185428	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	310	4	1	2	4.6	Cc1ccc(C(=O)O)cc1COc1ccc(Cl)cc1Cl	nan
	8977162	185496	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	4	3.6	COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1	nan
	CHEMBL4871542	185496	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	4	0	4	3.6	COC(=O)c1cccc(COc2ccc(C#N)cc2Cl)c1	nan
	155153984	185510	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	3	3.8	CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4871699	185510	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	304	5	1	3	3.8	CC(=O)c1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	3288323	185520	31	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	270	5	1	2	4.1	CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL4871766	185520	31	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	270	5	1	2	4.1	CC(C)c1ccc(OCc2cccc(C(=O)O)c2)cc1	nan
	155153862	185575	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	4	1	2	4.1	OCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4872542	185575	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	282	4	1	2	4.1	OCc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155146072	185598	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1	nan
	CHEMBL4872766	185598	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3cn[nH]n3)c2)c(Cl)c1	nan
	155153991	185670	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	CHEMBL4873848	185670	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1ccc(COc2ccc(Cl)cc2Cl)cc1C(=O)O	nan
	14974397	185688	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4874104	185688	1	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.0	O=C(O)c1cccc(COc2cccc(C(F)(F)F)c2)c1	nan
	155154050	185699	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	316	4	0	4	4.4	COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	CHEMBL4874272	185699	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	316	4	0	4	4.4	COC(=O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	81781305	185810	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4875899	185810	2	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	260	4	1	2	3.4	Cc1cc(F)ccc1OCc1cccc(C(=O)O)c1	nan
	155146174	185842	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	4	0	1	5.9	FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4876298	185842	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	4	0	1	5.9	FC(F)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154076	185897	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1	nan
	CHEMBL4877160	185897	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.4	O=C(O)c1cccc(COc2ccc(C(F)(F)F)nc2)c1	nan
	155153754	185991	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	327	5	0	5	2.9	COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1	nan
	CHEMBL4878462	185991	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	327	5	0	5	2.9	COC(=O)c1cccc(COc2ccc(N3CCOCC3)cc2)c1	nan
	155154070	186028	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4879226	186028	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	298	4	1	2	4.6	Cc1cc(C(C)(C)C)ccc1OCc1cccc(C(=O)O)c1	nan
	155154170	184155	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184155	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155145968	184432	2	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184432	2	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155154002	184275	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184275	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155145900	185516	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185516	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153792	185233	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185233	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	4366362	184092	33	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184092	33	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	4366362	184092	33	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184092	33	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155145968	184432	2	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184432	2	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146009	185761	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185761	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146147	185788	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185788	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145968	184432	2	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184432	2	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146136	185946	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185946	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145946	184679	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184679	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155146147	185788	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185788	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145946	184679	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184679	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155153902	184715	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184715	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145946	184679	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184679	5	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155153934	185461	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	335	4	1	3	4.2	Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1	nan
	CHEMBL4870947	185461	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	335	4	1	3	4.2	Cc1cc(C(F)(F)F)ccc1OCc1cc(C#N)cc(C(=O)O)c1	nan
	155154002	184275	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184275	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155145900	185516	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185516	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	106903214	185652	2	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	185652	2	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	155153792	185233	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185233	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153902	184715	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184715	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146009	185761	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185761	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146147	185788	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185788	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153792	185233	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185233	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155145946	184679	5	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184679	5	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155145900	185516	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185516	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146136	185946	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185946	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145968	184432	2	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184432	2	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146147	185788	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185788	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155154002	184275	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184275	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155146067	184014	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184014	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155145900	185516	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185516	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155145968	184432	2	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184432	2	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	106903214	185652	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	185652	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	4366362	184092	33	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184092	33	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155154251	184546	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184546	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153792	185233	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185233	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153792	185233	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185233	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155146136	185946	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185946	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155154251	184546	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184546	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153902	184715	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184715	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	107119671	184258	1	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184258	1	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	155146067	184014	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184014	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155146136	185946	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185946	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155145946	184679	5	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184679	5	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155145900	185516	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185516	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146009	185761	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185761	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146047	186005	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186005	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155146009	185761	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185761	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155146136	185946	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185946	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155146136	185946	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	CHEMBL4877820	185946	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)n1	nan
	155154251	184546	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184546	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155146147	185788	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4875642	185788	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	344	4	1	2	4.9	Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	4366362	184092	33	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184092	33	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155154251	184546	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184546	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155146009	185761	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	CHEMBL4875180	185761	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)ccc1F	nan
	155153902	184715	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184715	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155153902	184715	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4859372	184715	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	330	4	1	2	4.6	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	106903214	185652	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	185652	2	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	4366362	184092	33	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184092	33	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of BAR-502 by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155153780	185713	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185713	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155154170	184155	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184155	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154170	184155	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184155	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	890753	31388	36	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2cccc3ccccc23)c1	nan
	CHEMBL1404550	31388	36	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	4.1	O=C(O)c1cccc(COc2cccc3ccccc23)c1	nan
	155146086	183904	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	5	1	2	4.9	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1	nan
	CHEMBL4847344	183904	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	336	5	1	2	4.9	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1	nan
	155146130	183919	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	3	1	2	4.2	O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21	nan
	CHEMBL4847516	183919	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	3	1	2	4.2	O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21	nan
	155154149	183922	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	3.6	Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	CHEMBL4847582	183922	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	278	4	1	2	3.6	Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1	nan
	155153911	184069	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3ccoc3c2)c1	nan
	CHEMBL4849736	184069	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	268	4	1	3	3.7	O=C(O)c1cccc(COc2ccc3ccoc3c2)c1	nan
	155146026	184139	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1	nan
	CHEMBL4850676	184139	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	352	4	1	2	5.3	FC(F)(F)c1ccc(OCc2cccc(-c3cnc[nH]3)c2)c(Cl)c1	nan
	155154004	184141	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	5	1	3	3.3	COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F	nan
	CHEMBL4850688	184141	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	294	5	1	3	3.3	COc1ccc(OCc2cccc(C(=O)O)c2)c(F)c1F	nan
	19619635	184198	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	CHEMBL4851582	184198	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1cc(OCc2cccc(C(=O)O)c2)ccc1Cl	nan
	91105735	184201	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.1	O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1	nan
	CHEMBL4851614	184201	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.1	O=C(O)c1cccc(COc2ccc(F)cc2C(F)(F)F)c1	nan
	903815	184206	34	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL4851668	184206	34	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)cc1	nan
	155153785	184207	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1	nan
	CHEMBL4851669	184207	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	353	4	1	3	4.7	FC(F)(F)c1ccc(OCc2cccc(-c3nc[nH]n3)c2)c(Cl)c1	nan
	155154017	184305	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	1	3	4.3	COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4852989	184305	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	387	7	1	3	4.3	COCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	4442182	184307	37	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2cccc(Br)c2)c1	nan
	CHEMBL4853044	184307	37	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	306	4	1	2	3.7	O=C(O)c1cccc(COc2cccc(Br)c2)c1	nan
	103238459	184341	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	2	2	4.2	O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1	nan
	CHEMBL4853544	184341	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	4	2	2	4.2	O=C(O)c1cccc(CNc2ccc3ccccc3c2)c1	nan
	155154052	184361	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	338	4	1	2	4.1	C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4853811	184361	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	338	4	1	2	4.1	C#Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155146123	184468	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	366	4	1	3	4.2	O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4855464	184468	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	366	4	1	3	4.2	O=S(=O)(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155784453	184513	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856138	184513	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(N[C@H]1CC[C@H](O)CC1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155146049	184515	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	3	1	2	4.5	Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856167	184515	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	301	3	1	2	4.5	Nc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154204	184525	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4856296	184525	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	427	5	2	3	5.0	O=C(NC1CCCC(O)C1)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154013	184559	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	406	5	1	2	6.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1	nan
	CHEMBL4857004	184559	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	406	5	1	2	6.3	O=C(O)c1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(-c2ccccc2)c1	nan
	155153735	184669	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	5	1	3	4.4	O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F	nan
	CHEMBL4858571	184669	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	349	5	1	3	4.4	O=C(O)c1cccc(COc2ccc(N3CCCC3)cc2Cl)c1F	nan
	155153998	184733	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	279	4	1	3	3.5	O=C(O)c1cccc(COc2ccc3ccncc3c2)c1	nan
	CHEMBL4859587	184733	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	279	4	1	3	3.5	O=C(O)c1cccc(COc2ccc3ccncc3c2)c1	nan
	155153813	184829	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	6	2	3	3.4	CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861329	184829	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	6	2	3	3.4	CNC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154400	184834	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	7	1	3	4.2	CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4861423	184834	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	400	7	1	3	4.2	CN(C)CCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154049	184838	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	431	7	3	4	3.5	C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4861439	184838	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	431	7	3	4	3.5	C[C@@H](O)[C@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	155154027	184841	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl	nan
	CHEMBL4861452	184841	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1Cl	nan
	155146107	184880	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	362	4	0	3	4.9	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4861980	184880	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	362	4	0	3	4.9	COC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155154040	184999	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1	nan
	CHEMBL4863644	184999	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.1	FC(F)(F)c1ccc(OCc2ccc(-c3nnn[nH]3)cc2)c(Cl)c1	nan
	155153798	185052	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	7	2	3	3.9	CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4864507	185052	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	386	7	2	3	3.9	CNCCNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154046	185057	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	401	6	2	3	4.1	C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	CHEMBL4864569	185057	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	401	6	2	3	4.1	C[C@@H](NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O	nan
	106903207	185059	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	263	4	1	3	3.0	O=C(O)c1cccc(COc2ccc(Cl)cc2)n1	nan
	CHEMBL4864640	185059	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	263	4	1	3	3.0	O=C(O)c1cccc(COc2ccc(Cl)cc2)n1	nan
	155153702	185154	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	4	1	4	3.3	O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1	nan
	CHEMBL4866218	185154	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	308	4	1	4	3.3	O=C(O)c1cccc(COc2ccc3c(c2)OC(F)(F)O3)c1	nan
	62669913	185186	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	CHEMBL4866560	185186	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	276	4	1	2	3.9	Cc1ccc(OCc2cccc(C(=O)O)c2)c(Cl)c1	nan
	155153739	185246	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	3	4.0	Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4867549	185246	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	329	5	1	3	4.0	Cc1cc(N2CCCC2)ccc1OCc1cccc(C(=O)O)c1F	nan
	155153757	185283	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	4	0	4	4.1	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4868173	185283	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	345	4	0	4	4.1	COC(=O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	19620501	185301	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	CHEMBL4868548	185301	3	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	302	4	1	3	4.3	O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)s1	nan
	155701700	185320	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	274	4	1	2	3.7	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F	nan
	CHEMBL4868856	185320	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	274	4	1	2	3.7	Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1F	nan
	155153801	185328	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	322	5	1	2	4.8	O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1	nan
	CHEMBL4869062	185328	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	322	5	1	2	4.8	O=C(O)c1cccc(COc2cccc(-c3ccc(F)cc3)c2)c1	nan
	155153802	185527	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	0	3	4.4	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1	nan
	CHEMBL4871829	185527	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	0	3	4.4	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCOC1	nan
	155154216	185537	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	467	8	3	4	4.1	O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871932	185537	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	467	8	3	4	4.1	O=C(N[C@@H](Cc1c[nH]cn1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154203	185574	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	413	4	1	3	4.5	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1	nan
	CHEMBL4872532	185574	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	413	4	1	3	4.5	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CCCC(O)C1	nan
	155154200	185600	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	1	3	3.8	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1	nan
	CHEMBL4872809	185600	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	385	4	1	3	3.8	O=C(c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)N1CC(O)C1	nan
	155146160	185696	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	369	3	0	2	4.6	CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O	nan
	CHEMBL4874203	185696	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	369	3	0	2	4.6	CN1CCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc2C1=O	nan
	155146102	185726	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	4	1	2	4.5	O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1	nan
	CHEMBL4874670	185726	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	355	4	1	2	4.5	O=C1CC(c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)N1	nan
	29789593	185732	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	3	0	2	4.4	N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4874777	185732	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	277	3	0	2	4.4	N#Cc1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	20984378	185866	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	290	4	1	2	4.2	Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl	nan
	CHEMBL4876625	185866	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	290	4	1	2	4.2	Cc1cc(OCc2cccc(C(=O)O)c2)cc(C)c1Cl	nan
	155154217	185892	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	449	6	2	3	5.9	O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1	nan
	CHEMBL4877028	185892	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	449	6	2	3	5.9	O=C(O)c1ccc(NC(=O)c2cccc(COc3ccc(C(F)(F)F)cc3Cl)c2)cc1	nan
	155154152	185909	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1	nan
	CHEMBL4877399	185909	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	280	4	1	2	3.8	O=C(O)c1cccc(COc2ccc(Cl)cc2F)c1	nan
	155153804	185958	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.0	COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F	nan
	CHEMBL4878001	185958	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay	ChEMBL	326	5	1	3	4.0	COc1cc(OCc2cccc(C(=O)O)c2)ccc1C(F)(F)F	nan
	107119671	184258	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184258	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	4366362	184092	33	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	CHEMBL4850008	184092	33	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	296	4	1	2	4.3	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1	nan
	155145968	184432	2	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	CHEMBL4855031	184432	2	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1F	nan
	155146047	186005	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186005	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155153780	185713	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185713	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146067	184014	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184014	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155146067	184014	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4848977	184014	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	321	4	1	3	4.1	N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1	nan
	155153780	185713	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185713	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155154251	184546	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	CHEMBL4856731	184546	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	324	4	1	2	4.6	Cc1cc(COc2ccc(C(F)(F)F)cc2C)cc(C(=O)O)c1	nan
	155153792	185233	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	CHEMBL4867400	185233	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	330	4	1	2	4.9	O=C(O)c1cccc(COc2ccc(Cl)c(Cl)c2Cl)c1	nan
	155153780	185713	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185713	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146047	186005	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186005	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	155145946	184679	5	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	CHEMBL4858820	184679	5	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	359	5	1	3	4.6	CCc1cc(COc2ccc(C(F)(F)F)cc2Cl)nc(C(=O)O)c1	nan
	155154170	184155	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184155	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154002	184275	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184275	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	155153780	185713	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	CHEMBL4874540	185713	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of obeticholic acid by HTRF assay	ChEMBL	354	4	1	4	4.4	Clc1ccc(OCc2cccc(-c3nnn[nH]3)c2)c(Cl)c1Cl	nan
	155146047	186005	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	CHEMBL4878726	186005	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	355	4	1	3	4.5	N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1	nan
	106903214	185652	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	CHEMBL4873616	185652	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	297	4	1	3	3.7	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)n1	nan
	107119671	184258	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	CHEMBL4852376	184258	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	314	4	1	2	4.4	O=C(O)c1cccc(COc2ccc(Cl)cc2Cl)c1F	nan
	155145900	185516	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	CHEMBL4871722	185516	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay	ChEMBL	348	4	1	2	4.8	O=C(O)c1cc(F)cc(COc2ccc(C(F)(F)F)cc2Cl)c1	nan
	155154170	184155	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	CHEMBL4850889	184155	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 100 uM of conjugated bilirubin by HTRF assay	ChEMBL	331	4	1	3	4.0	O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1	nan
	155154002	184275	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan
	CHEMBL4852609	184275	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 50 uM of urobilin by HTRF assay	ChEMBL	328	4	1	2	4.4	Cc1cc(C(F)(F)F)ccc1OCc1cccc(C(=O)O)c1F	nan

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)