G15 -
5-HT2B receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
| Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
|---|---|---|---|---|---|---|---|---|
| Hydrophobic | C-term | M | 441 | - | G.hfs2 | M | 187 | G.hfs2.03 |
| Polar | ICL2 | N | 164 | 34x54 | G.H5 | R | 366 | G.H5.18 |
| Van-der-waals | ICL2 | N | 164 | 34x54 | G.H5 | R | 366 | G.H5.18 |
| Hydrophobic | TM4 | S | 168 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
| Van-der-waals | TM4 | S | 168 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
| Hydrophobic | ICL3 | L | 259 | - | G.S6 | Y | 343 | G.S6.05 |
| Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | V | 363 | G.H5.15 |
| Hydrophobic | ICL3 | T | 307 | - | G.H4 | T | 317 | G.H4.16 |
| Van-der-waals | ICL3 | T | 307 | - | G.H4 | T | 317 | G.H4.16 |
| Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 368 | G.H5.20 |
| Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 368 | G.H5.20 |
| Polar | ICL2 | Q | 162 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
| Polar | TM3 | D | 152 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
| Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | R | 360 | G.H5.12 |
| Hydrophobic | ICL2 | I | 161 | 34x51 | G.S3 | T | 202 | G.S3.01 |
| Van-der-waals | ICL2 | I | 161 | 34x51 | G.S3 | T | 202 | G.S3.01 |
| Hydrophobic | ICL3 | L | 259 | - | G.H4 | R | 310 | G.H4.09 |
| Van-der-waals | ICL3 | L | 259 | - | G.H4 | R | 310 | G.H4.09 |
| Polar | TM6 | A | 322 | 6x33 | G.H5 | L | 373 | G.H5.25 |
| Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 373 | G.H5.25 |
| Van-der-waals | TM6 | A | 322 | 6x33 | G.H5 | L | 373 | G.H5.25 |
| Polar | TM7 | Y | 380 | 7x53 | G.H5 | N | 372 | G.H5.24 |
| Van-der-waals | TM7 | Y | 380 | 7x53 | G.H5 | N | 372 | G.H5.24 |
| Hydrophobic | TM7 | F | 383 | 7x56 | G.H5 | N | 372 | G.H5.24 |
| Hydrophobic | C-term | I | 437 | - | G.S2 | Y | 195 | G.S2.04 |
| Van-der-waals | C-term | I | 437 | - | G.S2 | Y | 195 | G.S2.04 |
| Hydrophobic | ICL3 | L | 259 | - | G.H4 | E | 306 | G.H4.05 |
| Van-der-waals | ICL3 | L | 259 | - | G.H4 | E | 306 | G.H4.05 |
| Hydrophobic | ICL3 | W | 261 | - | G.H4 | D | 314 | G.H4.13 |
| Van-der-waals | ICL3 | W | 261 | - | G.H4 | D | 314 | G.H4.13 |
| Polar | H8 | N | 384 | 8x47 | G.H5 | E | 370 | G.H5.22 |
| Polar | ICL3 | K | 311 | - | G.S6 | S | 341 | G.S6.03 |
| Hydrophobic | C-term | N | 435 | - | G.h1ha | A | 68 | G.h1ha.02 |
| Hydrophobic | TM6 | L | 326 | 6x37 | G.H5 | L | 373 | G.H5.25 |
| Van-der-waals | TM6 | L | 326 | 6x37 | G.H5 | L | 373 | G.H5.25 |
| Polar | TM2 | Y | 87 | 2x37 | G.H5 | E | 370 | G.H5.22 |
| Hydrophobic | TM2 | Y | 87 | 2x37 | G.H5 | E | 370 | G.H5.22 |
| Van-der-waals | TM2 | Y | 87 | 2x37 | G.H5 | E | 370 | G.H5.22 |
| Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | L | 364 | G.H5.16 |
| Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | V | 363 | G.H5.15 |
| Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | V | 363 | G.H5.15 |
| Polar | TM3 | R | 153 | 3x50 | G.H5 | I | 371 | G.H5.23 |
| Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | I | 371 | G.H5.23 |
| Hydrophobic | TM2 | T | 89 | 2x39 | G.H5 | Y | 367 | G.H5.19 |
| Hydrophobic | C-term | L | 461 | - | G.H3 | T | 260 | G.H3.11 |
| Hydrophobic | ICL2 | I | 161 | 34x51 | G.S1 | L | 43 | G.S1.02 |
| Polar | TM3 | R | 153 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
| Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
| Van-der-waals | TM3 | R | 153 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
| Polar | ICL2 | Q | 165 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
| Hydrophobic | ICL2 | Q | 165 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
| Van-der-waals | ICL2 | Q | 165 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
| Polar | ICL3 | T | 260 | - | G.H4 | R | 310 | G.H4.09 |
| Van-der-waals | ICL3 | T | 260 | - | G.H4 | R | 310 | G.H4.09 |
| Hydrophobic | TM6 | N | 318 | 6x29 | G.H5 | L | 374 | G.H5.26 |
| Van-der-waals | TM6 | N | 318 | 6x29 | G.H5 | L | 374 | G.H5.26 |
| Polar | H8 | N | 384 | 8x47 | G.H5 | N | 372 | G.H5.24 |
| Hydrophobic | H8 | N | 384 | 8x47 | G.H5 | N | 372 | G.H5.24 |
| Van-der-waals | H8 | N | 384 | 8x47 | G.H5 | N | 372 | G.H5.24 |
| Hydrophobic | TM5 | K | 247 | 5x68 | G.H5 | L | 364 | G.H5.16 |
| Van-der-waals | TM5 | K | 247 | 5x68 | G.H5 | L | 364 | G.H5.16 |
| Polar | ICL2 | Q | 162 | 34x52 | G.S3 | T | 202 | G.S3.01 |
| Polar | TM6 | T | 315 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
| Hydrophobic | TM6 | T | 315 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
| Van-der-waals | TM6 | T | 315 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
| Hydrophobic | TM6 | V | 325 | 6x36 | G.H5 | L | 373 | G.H5.25 |
| Van-der-waals | TM6 | V | 325 | 6x36 | G.H5 | L | 373 | G.H5.25 |
| Hydrophobic | ICL3 | I | 308 | - | G.H4 | L | 313 | G.H4.12 |
| Van-der-waals | ICL3 | I | 308 | - | G.H4 | L | 313 | G.H4.12 |
| Hydrophobic | ICL2 | N | 164 | 34x54 | G.H5 | V | 363 | G.H5.15 |
| Van-der-waals | ICL2 | N | 164 | 34x54 | G.H5 | V | 363 | G.H5.15 |
| Hydrophobic | ICL2 | Q | 165 | 34x55 | G.S1 | L | 43 | G.S1.02 |
| Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | F | 356 | G.H5.08 |
| Van-der-waals | ICL2 | I | 161 | 34x51 | G.H5 | F | 356 | G.H5.08 |
| Hydrophobic | C-term | L | 464 | - | G.H3 | L | 264 | G.H3.15 |
| Polar | ICL2 | Q | 165 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
| Hydrophobic | ICL2 | Q | 165 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
| Van-der-waals | ICL2 | Q | 165 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
| Hydrophobic | C-term | I | 437 | - | G.S2 | F | 197 | G.S2.06 |
| Hydrophobic | TM3 | A | 156 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
| Van-der-waals | TM3 | A | 156 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
| Polar | C-term | I | 437 | - | G.H1 | R | 63 | G.H1.09 |
| Hydrophobic | C-term | I | 437 | - | G.H1 | R | 63 | G.H1.09 |
| Van-der-waals | C-term | I | 437 | - | G.H1 | R | 63 | G.H1.09 |
| Polar | TM6 | R | 321 | 6x32 | G.H5 | L | 374 | G.H5.26 |
| Hydrophobic | TM6 | R | 321 | 6x32 | G.H5 | L | 374 | G.H5.26 |
| Van-der-waals | TM6 | R | 321 | 6x32 | G.H5 | L | 374 | G.H5.26 |
| Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 364 | G.H5.16 |
| Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | R | 360 | G.H5.12 |
| Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | R | 360 | G.H5.12 |
| Hydrophobic | ICL3 | W | 261 | - | G.H4 | R | 310 | G.H4.09 |
| Polar | ICL3 | K | 311 | - | G.S6 | L | 339 | G.S6.01 |
| Hydrophobic | ICL3 | K | 311 | - | G.S6 | L | 339 | G.S6.01 |
| Van-der-waals | ICL3 | K | 311 | - | G.S6 | L | 339 | G.S6.01 |