G12 - α1A-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 132 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 132 34x51 G.H5 F 363 G.H5.08
Polar TM4 Q 140 4x39 G.HN R 52 G.HN.52
Hydrophobic TM4 Q 140 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 Q 140 4x39 G.HN R 52 G.HN.52
Polar ICL2 P 135 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 135 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 135 34x54 G.hns1 R 56 G.hns1.03
Polar C-term Y 386 - G.H2 Q 236 G.H2.05
Hydrophobic C-term Y 386 - G.H2 Q 236 G.H2.05
Van-der-waals C-term Y 386 - G.H2 Q 236 G.H2.05
Hydrophobic C-term V 375 - G.H3 T 279 G.H3.11
Van-der-waals C-term V 375 - G.H3 T 279 G.H3.11
Hydrophobic TM5 E 214 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM7 S 329 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 S 329 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM5 E 214 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 E 214 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 V 128 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 128 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM3 V 128 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 128 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 131 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 131 34x50 G.H5 K 367 G.H5.12
Polar TM6 R 266 6x29 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 132 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 132 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 P 131 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 131 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 R 124 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 124 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 E 214 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 E 214 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 V 210 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 R 133 34x52 G.S3 I 221 G.S3.01
Polar H8 Q 331 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 Q 331 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 331 8x48 G.H5 Q 381 G.H5.26
Polar TM3 G 127 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 G 127 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 127 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 L 218 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 V 128 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 128 3x54 G.H5 L 375 G.H5.20
Van-der-waals ICL3 D 225 - G.S6 H 348 G.S6.03
Ionic ICL3 D 225 - G.S6 H 348 G.S6.03
Polar ICL3 D 225 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 D 225 - G.S6 H 348 G.S6.03
Hydrophobic TM6 T 273 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 273 6x36 G.H5 I 378 G.H5.23
Polar ICL1 H 56 12x49 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 T 273 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 273 6x36 G.H5 L 380 G.H5.25
Polar TM7 S 329 7x56 G.H5 Q 381 G.H5.26
Van-der-waals TM7 S 329 7x56 G.H5 Q 381 G.H5.26
Hydrophobic C-term I 377 - G.H3 T 279 G.H3.11
Van-der-waals C-term I 377 - G.H3 T 279 G.H3.11
Hydrophobic TM5 L 218 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 L 218 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 266 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 266 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 266 6x29 G.H5 K 376 G.H5.21
Hydrophobic C-term K 390 - G.H3 K 284 G.H3.16
Van-der-waals C-term K 390 - G.H3 K 284 G.H3.16
Hydrophobic C-term W 397 - G.H2 F 239 G.H2.08
Van-der-waals C-term W 397 - G.H2 F 239 G.H2.08
Hydrophobic C-term V 379 - G.H2 R 232 G.H2.01
Hydrophobic ICL2 P 131 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL3 S 227 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 S 227 - G.H4 R 329 G.H4.09
Hydrophobic ICL2 P 135 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 135 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic C-term W 397 - G.h2s4 F 242 G.h2s4.01
Hydrophobic TM6 A 270 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 270 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM5 V 207 5x61 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 L 222 5x76 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM4 T 139 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 139 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic C-term G 380 - G.H2 R 232 G.H2.01
Ionic C-term D 373 - G.H3 K 284 G.H3.16
Polar C-term D 373 - G.H3 K 284 G.H3.16
Van-der-waals C-term D 373 - G.H3 K 284 G.H3.16
Hydrophobic C-term V 375 - G.H3 N 283 G.H3.15
Hydrophobic C-term C 395 - G.H3 L 285 G.H3.17
Polar TM6 R 266 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 266 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 L 218 5x72 G.S6 F 347 G.S6.02
Hydrophobic ICL2 L 132 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 132 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 L 132 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 L 274 6x37 G.H5 I 378 G.H5.23
Hydrophobic TM6 V 277 6x40 G.H5 L 380 G.H5.25
Polar TM6 T 273 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 273 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 273 6x36 G.H5 M 379 G.H5.24
Hydrophobic C-term P 378 - G.H3 N 275 G.H3.07
Hydrophobic ICL2 T 136 34x55 G.hns1 R 56 G.hns1.03
Polar ICL1 H 58 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 H 58 12x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 H 58 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 K 269 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM7 I 325 7x52 G.H5 L 380 G.H5.25
Polar C-term R 376 - G.H3 T 279 G.H3.11
Hydrophobic C-term R 376 - G.H3 T 279 G.H3.11
Van-der-waals C-term R 376 - G.H3 T 279 G.H3.11
Hydrophobic TM6 K 269 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 269 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM5 A 211 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 211 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM2 S 59 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 S 59 2x37 G.hns1 R 55 G.hns1.02