G15 - C5a1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 137 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 L 137 3x53 G.H5 Y 367 G.H5.19
Polar TM6 T 238 6x31 G.H5 L 373 G.H5.25
Hydrophobic TM6 T 238 6x31 G.H5 L 373 G.H5.25
Van-der-waals TM6 T 238 6x31 G.H5 L 373 G.H5.25
Hydrophobic ICL2 P 141 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 141 34x50 G.H5 R 360 G.H5.12
Polar ICL3 S 237 - G.H5 L 374 G.H5.26
Hydrophobic ICL3 S 237 - G.H5 L 374 G.H5.26
Van-der-waals ICL3 S 237 - G.H5 L 374 G.H5.26
Hydrophobic TM3 L 137 3x53 G.H5 I 371 G.H5.23
Van-der-waals TM3 L 137 3x53 G.H5 I 371 G.H5.23
Ionic ICL2 R 148 34x57 G.H5 E 370 G.H5.22
Hydrophobic TM5 R 232 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 R 232 5x68 G.H5 L 364 G.H5.16
Polar TM6 K 239 6x32 G.H5 L 373 G.H5.25
Hydrophobic TM6 K 239 6x32 G.H5 L 373 G.H5.25
Van-der-waals TM6 K 239 6x32 G.H5 L 373 G.H5.25
Polar TM6 T 240 6x33 G.H5 I 371 G.H5.23
Hydrophobic TM6 T 240 6x33 G.H5 I 371 G.H5.23
Van-der-waals TM6 T 240 6x33 G.H5 I 371 G.H5.23
Polar C-term K 333 - G.h2s4 F 223 G.h2s4.01
Van-der-waals C-term K 333 - G.h2s4 F 223 G.h2s4.01
Hydrophobic TM3 V 138 3x54 G.H5 L 368 G.H5.20
Hydrophobic TM5 T 229 5x65 G.H5 L 368 G.H5.20
Hydrophobic C-term E 326 - G.H5 E 370 G.H5.22
Polar ICL2 C 144 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 C 144 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 C 144 34x53 G.H5 Y 367 G.H5.19
Polar C-term V 322 - G.H5 N 372 G.H5.24
Van-der-waals C-term E 325 - G.H5 E 370 G.H5.22
Hydrophobic ICL2 I 142 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 I 142 34x51 G.H5 F 356 G.H5.08
Hydrophobic C-term K 333 - G.h2s4 E 224 G.h2s4.02
Polar C-term E 325 - G.H5 N 372 G.H5.24
Hydrophobic C-term E 325 - G.H5 N 372 G.H5.24
Van-der-waals C-term E 325 - G.H5 N 372 G.H5.24
Polar C-term F 307 - G.h4s6 K 332 G.h4s6.14
Hydrophobic C-term T 347 - G.S2 E 194 G.S2.03
Hydrophobic ICL2 P 141 34x50 G.H5 L 364 G.H5.16
Hydrophobic C-term V 350 - G.S2 F 197 G.S2.06
Hydrophobic ICL2 P 141 34x50 G.H5 V 363 G.H5.15
Hydrophobic TM6 K 239 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 K 239 6x32 G.H5 N 372 G.H5.24
Van-der-waals C-term F 307 - G.H5 L 374 G.H5.26
Polar TM6 T 240 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 T 240 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 T 240 6x33 G.H5 L 373 G.H5.25
Hydrophobic C-term V 350 - G.H1 R 63 G.H1.09
Van-der-waals C-term V 350 - G.H1 R 63 G.H1.09
Hydrophobic ICL3 T 235 - G.H5 L 364 G.H5.16
Van-der-waals ICL3 T 235 - G.H5 L 364 G.H5.16
Van-der-waals C-term V 350 - G.S2 C 196 G.S2.05
Hydrophobic C-term S 327 - G.H5 E 370 G.H5.22
Van-der-waals C-term S 327 - G.H5 E 370 G.H5.22
Hydrophobic ICL2 Q 145 34x54 G.h2s4 I 227 G.h2s4.05
Van-der-waals ICL2 Q 145 34x54 G.h2s4 I 227 G.h2s4.05
Hydrophobic TM6 K 239 6x32 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 K 239 6x32 G.h4s6 R 335 G.h4s6.17
Polar TM6 T 240 6x33 G.H5 N 372 G.H5.24
Hydrophobic TM6 T 240 6x33 G.H5 N 372 G.H5.24
Van-der-waals TM6 T 240 6x33 G.H5 N 372 G.H5.24
Polar C-term R 330 - G.hns1 R 40 G.hns1.02
Hydrophobic C-term R 330 - G.hns1 R 40 G.hns1.02
Van-der-waals C-term R 330 - G.hns1 R 40 G.hns1.02
Polar ICL2 Q 145 34x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 Q 145 34x54 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 Q 145 34x54 G.H5 Y 367 G.H5.19
Polar C-term K 333 - G.H3 W 266 G.H3.17
Hydrophobic C-term K 333 - G.H3 W 266 G.H3.17
Van-der-waals C-term K 333 - G.H3 W 266 G.H3.17
Hydrophobic TM3 R 134 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 I 371 G.H5.23
Hydrophobic ICL2 I 142 34x51 G.S3 T 202 G.S3.01
Van-der-waals ICL2 I 142 34x51 G.S3 T 202 G.S3.01
Polar ICL2 N 146 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 N 146 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 N 146 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 P 141 34x50 G.H5 Y 367 G.H5.19
Polar ICL2 P 141 34x50 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 P 141 34x50 G.H5 Y 367 G.H5.19
Polar C-term K 346 - G.S2 E 194 G.S2.03
Polar ICL2 N 146 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 N 146 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 N 146 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL3 A 234 - G.H5 D 361 G.H5.13
Hydrophobic ICL2 Q 145 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 Q 145 34x54 G.hns1 R 40 G.hns1.02
Polar C-term Q 348 - G.S2 E 194 G.S2.03
Van-der-waals C-term Q 348 - G.S2 E 194 G.S2.03
Hydrophobic TM5 R 232 5x68 G.H5 R 360 G.H5.12
Van-der-waals TM5 R 232 5x68 G.H5 R 360 G.H5.12
Hydrophobic TM3 L 137 3x53 G.H5 L 364 G.H5.16
Van-der-waals TM3 L 137 3x53 G.H5 L 364 G.H5.16
Hydrophobic ICL3 T 235 - G.H5 L 368 G.H5.20
Van-der-waals ICL3 T 235 - G.H5 L 368 G.H5.20
Polar ICL3 A 234 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL3 A 234 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 A 234 - G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL2 Q 145 34x54 G.H5 V 363 G.H5.15
Van-der-waals ICL2 Q 145 34x54 G.H5 V 363 G.H5.15
Hydrophobic C-term V 350 - G.S2 Y 195 G.S2.04
Van-der-waals C-term V 350 - G.S2 Y 195 G.S2.04
Polar ICL3 S 237 - G.H5 L 373 G.H5.25
Hydrophobic ICL3 S 237 - G.H5 L 373 G.H5.25
Van-der-waals ICL3 S 237 - G.H5 L 373 G.H5.25
Hydrophobic TM6 L 241 6x34 G.H5 L 373 G.H5.25
Van-der-waals TM6 L 241 6x34 G.H5 L 373 G.H5.25
Hydrophobic ICL2 I 142 34x51 G.S1 L 43 G.S1.02
Ionic TM5 R 232 5x68 G.H5 D 361 G.H5.13
Polar TM5 R 232 5x68 G.H5 D 361 G.H5.13
Hydrophobic TM5 R 232 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 R 232 5x68 G.H5 D 361 G.H5.13
Hydrophobic ICL2 I 142 34x51 G.H5 R 360 G.H5.12
Polar C-term N 321 - G.H5 N 372 G.H5.24
Van-der-waals C-term N 321 - G.H5 N 372 G.H5.24
Hydrophobic TM3 V 138 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 V 138 3x54 G.H5 L 364 G.H5.16
Hydrophobic C-term F 307 - G.H5 N 372 G.H5.24
Polar C-term Q 345 - G.S2 E 194 G.S2.03
Hydrophobic ICL2 Q 145 34x54 G.S1 L 43 G.S1.02
Van-der-waals ICL2 Q 145 34x54 G.S1 L 43 G.S1.02
Polar ICL2 R 148 34x57 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 K 239 6x32 G.H5 L 374 G.H5.26
Polar TM2 N 71 2x39 G.H5 E 370 G.H5.22
Van-der-waals TM2 N 71 2x39 G.H5 E 370 G.H5.22