Gi3 - CT receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 253 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 253 - G.s2s3 K 192 G.s2s3.01
Polar TM6 A 341 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 341 6x38 G.H5 L 353 G.H5.25
Polar TM6 Y 338 6x35 G.H5 D 341 G.H5.13
Ionic TM5 K 326 5x64 G.H5 D 341 G.H5.13
Polar TM5 K 326 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 326 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 326 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM6 M 337 6x34 G.H5 Y 354 G.H5.26
Van-der-waals TM6 M 337 6x34 G.H5 Y 354 G.H5.26
Ionic ICL2 E 255 - G.hns1 K 32 G.hns1.03
Polar ICL2 E 255 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 E 255 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 E 255 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term I 442 - G.H2 K 209 G.H2.05
Polar C-term H 444 - G.H2 K 209 G.H2.05
Van-der-waals TM2 R 180 2x46 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 252 - G.H5 I 344 G.H5.16
Polar TM2 R 180 2x46 G.H5 E 350 G.H5.22
Hydrophobic TM2 R 180 2x46 G.H5 E 350 G.H5.22
Van-der-waals TM2 R 180 2x46 G.H5 E 350 G.H5.22
Hydrophobic ICL2 T 254 - G.s2s3 D 193 G.s2s3.02
Ionic ICL2 K 256 - G.HN E 28 G.HN.52
Hydrophobic ICL2 K 256 - G.HN E 28 G.HN.52
Van-der-waals ICL2 K 256 - G.HN E 28 G.HN.52
Polar TM3 L 247 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 247 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 247 3x57 G.H5 N 347 G.H5.19
Polar ICL2 K 256 - G.HN R 24 G.HN.48
Van-der-waals ICL2 K 256 - G.HN R 24 G.HN.48
Hydrophobic TM6 T 345 6x42 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 244 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 244 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 247 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 247 3x57 G.H5 C 351 G.H5.23
Hydrophobic TM5 K 326 5x64 G.H5 I 344 G.H5.16
Aromatic TM6 K 340 6x37 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 340 6x37 G.H5 Y 354 G.H5.26
Hydrophobic TM6 M 337 6x34 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 M 337 6x34 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 F 253 - G.H5 T 340 G.H5.12
Hydrophobic TM6 A 341 6x38 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 244 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 253 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 V 252 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 252 - G.H5 I 343 G.H5.15
Hydrophobic TM6 A 344 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 344 6x41 G.H5 L 353 G.H5.25
Polar TM6 E 334 6x31 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 E 334 6x31 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 E 334 6x31 G.h4s6 E 318 G.h4s6.12
Polar ICL2 V 252 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 256 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 323 5x61 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 323 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM6 E 334 6x31 G.S6 Y 320 G.S6.02
Van-der-waals TM6 E 334 6x31 G.S6 Y 320 G.S6.02
Polar ICL2 K 256 - G.HN G 27 G.HN.51
Hydrophobic ICL2 K 256 - G.HN G 27 G.HN.51
Van-der-waals ICL2 K 256 - G.HN G 27 G.HN.51
Hydrophobic ICL2 F 253 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 253 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 254 - G.hns1 K 32 G.hns1.03
Polar TM2 R 180 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 180 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 180 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM6 M 337 6x34 G.H5 K 345 G.H5.17
Van-der-waals TM6 M 337 6x34 G.H5 K 345 G.H5.17
Hydrophobic ICL2 F 253 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 L 194 G.S3.01
Hydrophobic TM6 L 348 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 348 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 248 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 248 3x58 G.H5 L 348 G.H5.20