G14 - CaS receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 72.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 711 - G.H5 E 351 G.H5.22
Van-der-waals ICL2 P 711 - G.H5 E 351 G.H5.22
Hydrophobic C-term V 883 - G.H5 K 341 G.H5.12
Van-der-waals C-term V 883 - G.H5 K 341 G.H5.12
Polar ICL2 K 709 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 K 709 - G.s2s3 N 194 G.s2s3.02
Polar H8 R 873 8x55 G.H5 Q 346 G.H5.17
Hydrophobic H8 R 873 8x55 G.H5 Q 346 G.H5.17
Van-der-waals H8 R 873 8x55 G.H5 Q 346 G.H5.17
Polar C-term F 1062 - G.H2 R 210 G.H2.05
Hydrophobic C-term I 1064 - G.H2 R 210 G.H2.05
Hydrophobic C-term T 974 - G.H4 L 306 G.H4.12
Van-der-waals C-term T 974 - G.H4 L 306 G.H4.12
Hydrophobic C-term L 977 - G.h4s6 V 319 G.h4s6.20
Van-der-waals C-term L 977 - G.h4s6 V 319 G.h4s6.20
Hydrophobic C-term A 887 - G.S2 L 192 G.S2.08
Hydrophobic ICL2 K 709 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 K 709 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 I 710 - G.S1 E 35 G.S1.01
Van-der-waals ICL2 I 710 - G.S1 E 35 G.S1.01
Polar C-term A 877 - G.H5 D 342 G.H5.13
Hydrophobic C-term A 877 - G.H5 D 342 G.H5.13
Polar C-term S 976 - G.H4 Q 310 G.H4.16
Hydrophobic C-term S 976 - G.H4 Q 310 G.H4.16
Van-der-waals C-term S 976 - G.H4 Q 310 G.H4.16
Hydrophobic H8 I 869 8x51 G.H5 V 355 G.H5.26
Polar C-term F 979 - G.h4s6 K 316 G.h4s6.11
Polar C-term T 876 - G.H5 D 342 G.H5.13
Van-der-waals C-term T 876 - G.H5 D 342 G.H5.13
Hydrophobic C-term A 880 - G.H5 A 338 G.H5.09
Polar C-term S 976 - G.S6 I 320 G.S6.01
Hydrophobic C-term A 887 - G.H5 F 337 G.H5.08
Van-der-waals C-term A 887 - G.H5 F 337 G.H5.08
Polar ICL1 A 645 12x52 G.H5 L 354 G.H5.25
Hydrophobic ICL1 A 645 12x52 G.H5 L 354 G.H5.25
Van-der-waals ICL1 A 645 12x52 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 705 3x57 G.H5 F 352 G.H5.23
Van-der-waals TM3 V 705 3x57 G.H5 F 352 G.H5.23
Hydrophobic C-term F 975 - G.h4s6 V 319 G.h4s6.20
Van-der-waals C-term F 975 - G.h4s6 V 319 G.h4s6.20
Van-der-waals C-term D 980 - G.h4s6 K 316 G.h4s6.11
Ionic C-term D 980 - G.h4s6 K 316 G.h4s6.11
Polar C-term D 980 - G.h4s6 K 316 G.h4s6.11
Hydrophobic C-term D 980 - G.h4s6 K 316 G.h4s6.11
Polar C-term R 891 - G.S2 D 191 G.S2.07
Hydrophobic C-term R 891 - G.S2 D 191 G.S2.07
Van-der-waals C-term R 891 - G.S2 D 191 G.S2.07
Hydrophobic C-term G 971 - G.S6 H 323 G.S6.04
Van-der-waals C-term G 971 - G.S6 H 323 G.S6.04
Polar ICL2 P 711 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 711 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 711 - G.H5 N 348 G.H5.19
Polar ICL2 K 709 - G.H5 N 348 G.H5.19
Hydrophobic C-term A 880 - G.H5 D 342 G.H5.13
Polar C-term T 888 - G.H5 R 334 G.H5.05
Hydrophobic C-term T 888 - G.H5 R 334 G.H5.05
Van-der-waals C-term T 888 - G.H5 R 334 G.H5.05
Hydrophobic ICL2 K 709 - G.S3 I 195 G.S3.01
Hydrophobic C-term A 880 - G.H5 K 341 G.H5.12
Polar TM3 R 701 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 701 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 701 3x53 G.H5 F 352 G.H5.23
Hydrophobic C-term F 975 - G.S6 Y 321 G.S6.02
Van-der-waals C-term F 975 - G.S6 Y 321 G.S6.02
Hydrophobic C-term L 889 - G.H5 R 334 G.H5.05
Van-der-waals C-term L 889 - G.H5 R 334 G.H5.05
Hydrophobic TM3 V 705 3x57 G.H5 L 349 G.H5.20
Hydrophobic TM2 N 647 2x35 G.H5 L 354 G.H5.25
Hydrophobic ICL2 I 710 - G.S1 L 36 G.S1.02
Van-der-waals ICL2 I 710 - G.S1 L 36 G.S1.02
Hydrophobic C-term A 884 - G.H5 F 337 G.H5.08
Van-der-waals C-term A 884 - G.H5 F 337 G.H5.08
Polar ICL1 K 644 12x51 G.H5 V 355 G.H5.26
Hydrophobic ICL1 K 644 12x51 G.H5 V 355 G.H5.26
Van-der-waals ICL1 K 644 12x51 G.H5 V 355 G.H5.26
Aromatic C-term F 881 - G.H5 F 335 G.H5.06
Hydrophobic C-term F 881 - G.H5 F 335 G.H5.06
Van-der-waals C-term F 881 - G.H5 F 335 G.H5.06
Hydrophobic ICL2 P 711 - G.H5 I 344 G.H5.15
Hydrophobic C-term T 888 - G.H5 I 333 G.H5.04
Ionic C-term K 965 - G.H4 D 303 G.H4.09
Polar C-term K 965 - G.H4 D 303 G.H4.09
Van-der-waals C-term K 965 - G.H4 D 303 G.H4.09
Hydrophobic TM3 V 705 3x57 G.H5 L 354 G.H5.25
Hydrophobic ICL2 I 710 - G.H5 I 344 G.H5.15
Hydrophobic ICL3 F 801 - G.H5 L 349 G.H5.20
Van-der-waals ICL3 F 801 - G.H5 L 349 G.H5.20
Polar TM3 V 705 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 V 705 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 V 705 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 R 701 3x53 G.H5 L 354 G.H5.25
Hydrophobic C-term A 885 - G.H5 R 334 G.H5.05
Hydrophobic TM3 V 705 3x57 G.H5 L 345 G.H5.16
Hydrophobic C-term A 887 - G.s2s3 E 193 G.s2s3.01
Van-der-waals C-term A 887 - G.s2s3 E 193 G.s2s3.01
Hydrophobic ICL2 I 710 - G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 I 710 - G.hns1 R 33 G.hns1.02
Hydrophobic C-term A 884 - G.H5 A 338 G.H5.09
Van-der-waals C-term A 884 - G.H5 A 338 G.H5.09
Hydrophobic C-term T 888 - G.H1 H 59 G.H1.12
Hydrophobic C-term T 876 - G.H5 L 349 G.H5.20
Van-der-waals C-term T 876 - G.H5 L 349 G.H5.20
Polar ICL2 A 708 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 A 708 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 A 708 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 I 710 - G.hns1 R 34 G.hns1.03
Hydrophobic C-term F 881 - G.H5 A 338 G.H5.09
Van-der-waals C-term F 881 - G.H5 A 338 G.H5.09
Polar C-term S 978 - G.h4s6 K 316 G.h4s6.11
Hydrophobic C-term S 978 - G.h4s6 K 316 G.h4s6.11
Van-der-waals C-term S 978 - G.h4s6 K 316 G.h4s6.11
Van-der-waals C-term R 891 - G.S2 L 192 G.S2.08
Hydrophobic ICL1 K 644 12x51 G.H5 L 354 G.H5.25
Polar C-term R 891 - G.H1 H 59 G.H1.12
Hydrophobic C-term R 891 - G.H1 H 59 G.H1.12
Van-der-waals C-term R 891 - G.H1 H 59 G.H1.12
Hydrophobic H8 R 873 8x55 G.h4s6 V 319 G.h4s6.20
Van-der-waals H8 R 873 8x55 G.h4s6 V 319 G.h4s6.20
Polar C-term T 974 - G.H4 Q 310 G.H4.16
Van-der-waals C-term T 974 - G.H4 Q 310 G.H4.16
Ionic C-term R 890 - G.s2s3 E 193 G.s2s3.01
Hydrophobic TM3 F 706 3x58 G.H5 L 345 G.H5.16
Van-der-waals TM3 F 706 3x58 G.H5 L 345 G.H5.16
Polar C-term T 876 - G.H5 Q 346 G.H5.17
Van-der-waals C-term T 876 - G.H5 Q 346 G.H5.17
Polar C-term T 974 - G.S6 S 322 G.S6.03
Van-der-waals C-term T 974 - G.S6 S 322 G.S6.03
Polar ICL2 T 712 - G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 T 712 - G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 T 712 - G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 W 719 - G.H5 F 352 G.H5.23
Van-der-waals ICL2 W 719 - G.H5 F 352 G.H5.23
Hydrophobic C-term T 876 - G.H5 L 345 G.H5.16
Hydrophobic C-term T 888 - G.S2 L 192 G.S2.08
Hydrophobic C-term V 973 - G.H5 F 335 G.H5.06
Van-der-waals C-term V 973 - G.H5 F 335 G.H5.06
Ionic ICL2 R 716 - G.H5 E 351 G.H5.22
Polar ICL2 R 716 - G.H5 E 351 G.H5.22
Hydrophobic ICL2 R 716 - G.H5 E 351 G.H5.22
Van-der-waals ICL2 R 716 - G.H5 E 351 G.H5.22
Polar ICL2 S 713 - G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 S 713 - G.hns1 R 33 G.hns1.02