Gz - CaS receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 68.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 18.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 711 - G.H5 Y 351 G.H5.22
Hydrophobic ICL2 P 711 - G.H5 Y 351 G.H5.22
Van-der-waals ICL2 P 711 - G.H5 Y 351 G.H5.22
Hydrophobic H8 R 873 8x55 G.H5 L 349 G.H5.20
Hydrophobic C-term A 884 - G.S3 L 195 G.S3.01
Van-der-waals C-term A 884 - G.S3 L 195 G.S3.01
Polar C-term S 978 - G.h2s4 F 216 G.h2s4.01
Polar H8 R 873 8x55 G.H5 Q 346 G.H5.17
Hydrophobic H8 R 873 8x55 G.H5 Q 346 G.H5.17
Van-der-waals H8 R 873 8x55 G.H5 Q 346 G.H5.17
Polar C-term R 891 - G.S3 T 196 G.S3.02
Van-der-waals C-term R 891 - G.S3 T 196 G.S3.02
Polar TM3 R 701 3x53 G.H5 G 353 G.H5.24
Hydrophobic TM3 R 701 3x53 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 701 3x53 G.H5 G 353 G.H5.24
Hydrophobic ICL2 I 710 - G.h2s4 G 218 G.h2s4.03
Van-der-waals ICL2 I 710 - G.h2s4 G 218 G.h2s4.03
Aromatic C-term F 881 - G.S3 F 197 G.S3.03
Hydrophobic C-term F 881 - G.S3 F 197 G.S3.03
Van-der-waals C-term F 881 - G.S3 F 197 G.S3.03
Hydrophobic C-term T 888 - G.S3 L 195 G.S3.01
Van-der-waals C-term T 888 - G.S3 L 195 G.S3.01
Hydrophobic TM3 F 706 3x58 G.H5 L 354 G.H5.25
Hydrophobic C-term A 885 - G.s2s3 K 193 G.s2s3.01
Van-der-waals C-term A 885 - G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term A 877 - G.H5 D 342 G.H5.13
Van-der-waals C-term A 877 - G.H5 D 342 G.H5.13
Hydrophobic C-term A 885 - G.s2s3 E 194 G.s2s3.02
Van-der-waals C-term A 885 - G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 716 - G.H5 K 350 G.H5.21
Hydrophobic C-term L 889 - G.S2 T 191 G.S2.07
Van-der-waals C-term L 889 - G.S2 T 191 G.S2.07
Hydrophobic H8 V 872 8x54 G.H5 L 349 G.H5.20
Van-der-waals H8 V 872 8x54 G.H5 L 349 G.H5.20
Hydrophobic ICL3 N 800 - G.H5 L 354 G.H5.25
Van-der-waals ICL3 N 800 - G.H5 L 354 G.H5.25
Polar C-term T 888 - G.S3 T 196 G.S3.02
Hydrophobic C-term T 888 - G.S3 T 196 G.S3.02
Van-der-waals C-term T 888 - G.S3 T 196 G.S3.02
Hydrophobic C-term T 972 - G.S2 K 189 G.S2.05
Van-der-waals C-term T 972 - G.S2 K 189 G.S2.05
Polar ICL2 K 709 - G.HN S 27 G.HN.51
Hydrophobic H8 R 873 8x55 G.H5 I 345 G.H5.16
Van-der-waals H8 R 873 8x55 G.H5 I 345 G.H5.16
Hydrophobic ICL1 A 645 12x52 G.H5 L 354 G.H5.25
Van-der-waals ICL1 A 645 12x52 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 705 3x57 G.H5 I 352 G.H5.23
Van-der-waals TM3 V 705 3x57 G.H5 I 352 G.H5.23
Polar H8 C 874 8x56 G.H5 D 342 G.H5.13
Hydrophobic H8 C 874 8x56 G.H5 D 342 G.H5.13
Van-der-waals H8 C 874 8x56 G.H5 D 342 G.H5.13
Polar C-term A 884 - G.S3 T 196 G.S3.02
Polar C-term F 975 - G.S2 E 187 G.S2.03
Hydrophobic C-term F 975 - G.S2 E 187 G.S2.03
Van-der-waals C-term F 975 - G.S2 E 187 G.S2.03
Hydrophobic C-term F 881 - G.s2s3 K 193 G.s2s3.01
Van-der-waals C-term F 881 - G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term F 881 - G.S1 I 34 G.S1.02
Van-der-waals C-term F 881 - G.S1 I 34 G.S1.02
Hydrophobic C-term A 877 - G.H5 I 345 G.H5.16
Van-der-waals C-term A 877 - G.H5 I 345 G.H5.16
Polar H8 R 873 8x55 G.H5 C 355 G.H5.26
Hydrophobic H8 R 873 8x55 G.H5 C 355 G.H5.26
Van-der-waals H8 R 873 8x55 G.H5 C 355 G.H5.26
Polar H8 E 870 8x52 G.H5 Q 346 G.H5.17
Van-der-waals H8 E 870 8x52 G.H5 Q 346 G.H5.17
Polar TM3 R 701 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 701 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL2 K 709 - G.hns1 R 31 G.hns1.02
Polar C-term T 974 - G.S3 K 198 G.S3.04
Van-der-waals C-term T 974 - G.S3 K 198 G.S3.04
Hydrophobic C-term F 968 - G.S2 T 191 G.S2.07
Van-der-waals C-term F 968 - G.S2 T 191 G.S2.07
Ionic C-term R 891 - G.S1 E 33 G.S1.01
Polar C-term R 891 - G.S1 E 33 G.S1.01
Van-der-waals C-term R 891 - G.S1 E 33 G.S1.01
Hydrophobic C-term F 881 - G.S3 L 195 G.S3.01
Van-der-waals C-term F 881 - G.S3 L 195 G.S3.01
Polar C-term T 974 - G.S2 K 189 G.S2.05
Hydrophobic C-term T 974 - G.S2 K 189 G.S2.05
Van-der-waals C-term T 974 - G.S2 K 189 G.S2.05
Polar C-term A 887 - G.HN R 29 G.HN.53
Hydrophobic C-term A 887 - G.HN R 29 G.HN.53
Van-der-waals C-term A 887 - G.HN R 29 G.HN.53
Hydrophobic C-term F 881 - G.H5 I 345 G.H5.16
Van-der-waals C-term F 881 - G.H5 I 345 G.H5.16
Polar C-term F 979 - G.h2s4 E 217 G.h2s4.02
Hydrophobic C-term F 979 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term F 979 - G.h2s4 E 217 G.h2s4.02
Polar C-term F 975 - G.S3 K 198 G.S3.04
Van-der-waals C-term F 975 - G.S3 K 198 G.S3.04
Polar ICL2 R 716 - G.h3s5 N 262 G.h3s5.02
Van-der-waals ICL2 R 716 - G.h3s5 N 262 G.h3s5.02
Hydrophobic TM3 V 705 3x57 G.H5 L 354 G.H5.25
Van-der-waals TM3 V 705 3x57 G.H5 L 354 G.H5.25
Polar ICL2 A 708 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 708 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 A 708 - G.hns1 R 31 G.hns1.02
Ionic C-term R 886 - G.s2s3 E 194 G.s2s3.02
Polar C-term R 886 - G.s2s3 E 194 G.s2s3.02
Hydrophobic C-term R 886 - G.s2s3 E 194 G.s2s3.02
Van-der-waals C-term R 886 - G.s2s3 E 194 G.s2s3.02
Hydrophobic C-term K 882 - G.s2s3 E 194 G.s2s3.02
Van-der-waals C-term K 882 - G.s2s3 E 194 G.s2s3.02
Polar H8 R 873 8x55 G.H5 N 347 G.H5.18
Hydrophobic C-term A 885 - G.S3 L 195 G.S3.01
Van-der-waals C-term A 885 - G.S3 L 195 G.S3.01
Hydrophobic C-term T 888 - G.S2 T 191 G.S2.07
Van-der-waals C-term T 888 - G.S2 T 191 G.S2.07
Polar C-term S 976 - G.S1 K 35 G.S1.03
Hydrophobic C-term T 876 - G.H5 L 349 G.H5.20
Van-der-waals C-term T 876 - G.H5 L 349 G.H5.20
Polar C-term R 890 - G.HN R 29 G.HN.53
Hydrophobic C-term R 890 - G.HN R 29 G.HN.53
Van-der-waals C-term R 890 - G.HN R 29 G.HN.53
Hydrophobic C-term F 881 - G.H5 T 341 G.H5.12
Van-der-waals C-term F 881 - G.H5 T 341 G.H5.12
Polar C-term V 883 - G.hns1 R 32 G.hns1.03
Hydrophobic C-term V 883 - G.hns1 R 32 G.hns1.03
Van-der-waals C-term V 883 - G.hns1 R 32 G.hns1.03
Polar C-term T 974 - G.S2 E 187 G.S2.03
Hydrophobic C-term T 974 - G.S2 E 187 G.S2.03
Van-der-waals C-term T 974 - G.S2 E 187 G.S2.03
Polar C-term S 978 - G.S1 K 35 G.S1.03
Hydrophobic C-term A 887 - G.hns1 R 32 G.hns1.03
Van-der-waals C-term A 887 - G.hns1 R 32 G.hns1.03
Polar ICL2 E 707 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 E 707 - G.hns1 R 31 G.hns1.02
Hydrophobic C-term A 884 - G.hns1 R 32 G.hns1.03
Van-der-waals C-term A 884 - G.hns1 R 32 G.hns1.03
Hydrophobic C-term R 891 - G.HN R 29 G.HN.53
Van-der-waals C-term R 891 - G.HN R 29 G.HN.53
Polar C-term S 978 - G.h2s4 E 217 G.h2s4.02
Hydrophobic C-term S 978 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term S 978 - G.h2s4 E 217 G.h2s4.02
Hydrophobic C-term F 975 - G.S2 I 185 G.S2.01
Van-der-waals C-term F 975 - G.S2 I 185 G.S2.01
Hydrophobic C-term D 980 - G.H3 W 259 G.H3.17
Van-der-waals C-term D 980 - G.H3 W 259 G.H3.17
Ionic C-term R 891 - G.HN E 26 G.HN.50
Polar C-term R 891 - G.HN E 26 G.HN.50
Hydrophobic C-term R 891 - G.HN E 26 G.HN.50
Van-der-waals C-term R 891 - G.HN E 26 G.HN.50
Hydrophobic C-term V 973 - G.S2 E 187 G.S2.03
Van-der-waals C-term V 973 - G.S2 E 187 G.S2.03
Polar C-term S 978 - G.H2 H 214 G.H2.09
Polar C-term S 976 - G.S3 K 198 G.S3.04
Van-der-waals C-term S 976 - G.S3 K 198 G.S3.04
Hydrophobic C-term T 876 - G.H5 I 345 G.H5.16
Van-der-waals C-term T 876 - G.H5 I 345 G.H5.16
Hydrophobic C-term V 973 - G.S2 K 189 G.S2.05
Polar C-term T 888 - G.s2s3 E 194 G.s2s3.02
Hydrophobic C-term T 888 - G.s2s3 E 194 G.s2s3.02
Van-der-waals C-term T 888 - G.s2s3 E 194 G.s2s3.02
Polar C-term L 889 - G.s2s3 E 194 G.s2s3.02
Hydrophobic C-term L 889 - G.s2s3 E 194 G.s2s3.02
Van-der-waals C-term L 889 - G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 716 - G.H5 Y 351 G.H5.22
Aromatic ICL2 R 716 - G.H5 Y 351 G.H5.22
Hydrophobic ICL2 R 716 - G.H5 Y 351 G.H5.22
Van-der-waals ICL2 R 716 - G.H5 Y 351 G.H5.22
Hydrophobic C-term V 973 - G.S2 N 188 G.S2.04