G14 - D4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 140 34x50 G.S3 I 195 G.S3.01
Van-der-waals ICL2 P 140 34x50 G.S3 I 195 G.S3.01
Hydrophobic ICL2 P 140 34x50 G.H5 L 345 G.H5.16
Polar ICL2 Q 146 34x56 G.hns1 A 32 G.hns1.01
Hydrophobic ICL2 Q 146 34x56 G.hns1 A 32 G.hns1.01
Van-der-waals ICL2 Q 146 34x56 G.hns1 A 32 G.hns1.01
Hydrophobic ICL2 R 145 34x55 G.hns1 A 32 G.hns1.01
Van-der-waals ICL2 R 145 34x55 G.hns1 A 32 G.hns1.01
Hydrophobic TM5 W 222 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 W 222 5x68 G.H5 D 342 G.H5.13
Polar ICL2 R 145 34x55 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 R 145 34x55 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 R 145 34x55 G.hns1 R 34 G.hns1.03
Polar TM3 R 133 3x50 G.H5 L 349 G.H5.20
Hydrophobic ICL3 R 233 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 R 233 - G.H5 F 335 G.H5.06
Hydrophobic TM3 I 129 3x46 G.H5 V 355 G.H5.26
Van-der-waals TM3 I 129 3x46 G.H5 V 355 G.H5.26
Hydrophobic ICL2 P 140 34x50 G.H5 L 349 G.H5.20
Van-der-waals ICL2 P 140 34x50 G.H5 L 349 G.H5.20
Polar TM7 L 381 7x33 G.H4 Q 310 G.H4.16
Van-der-waals TM7 L 381 7x33 G.H4 Q 310 G.H4.16
Polar TM3 V 139 3x56 G.hns1 R 34 G.hns1.03
Hydrophobic TM5 W 222 5x68 G.H5 Q 346 G.H5.17
Van-der-waals TM5 W 222 5x68 G.H5 Q 346 G.H5.17
Ionic ICL2 R 145 34x55 G.HN D 28 G.HN.50
Polar ICL2 R 145 34x55 G.HN D 28 G.HN.50
Van-der-waals ICL2 R 145 34x55 G.HN D 28 G.HN.50
Polar ICL2 R 142 34x52 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 142 34x52 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 142 34x52 G.s2s3 N 194 G.s2s3.02
Polar ICL2 L 141 34x51 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 L 141 34x51 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 L 141 34x51 G.hns1 R 34 G.hns1.03
Hydrophobic TM3 V 137 3x54 G.H5 L 349 G.H5.20
Polar ICL2 R 145 34x55 G.S3 I 195 G.S3.01
Hydrophobic ICL2 R 145 34x55 G.S3 I 195 G.S3.01
Van-der-waals ICL2 R 145 34x55 G.S3 I 195 G.S3.01
Hydrophobic TM2 I 73 2x43 G.H5 L 354 G.H5.25
Aromatic ICL2 Y 143 34x53 G.H5 F 352 G.H5.23
Hydrophobic ICL2 Y 143 34x53 G.H5 F 352 G.H5.23
Polar ICL2 R 145 34x55 G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 R 145 34x55 G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 R 145 34x55 G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 N 144 34x54 G.S1 L 36 G.S1.02
Hydrophobic TM7 V 385 7x37 G.H5 Q 346 G.H5.17
Hydrophobic TM7 I 399 7x52 G.H5 V 355 G.H5.26
Hydrophobic TM5 W 222 5x68 G.H5 L 345 G.H5.16
Polar TM3 R 133 3x50 G.H5 V 355 G.H5.26
Hydrophobic TM3 R 133 3x50 G.H5 V 355 G.H5.26
Van-der-waals TM3 R 133 3x50 G.H5 V 355 G.H5.26
Polar TM5 R 226 5x72 G.H5 T 343 G.H5.14
Van-der-waals TM5 R 226 5x72 G.H5 T 343 G.H5.14
Polar ICL2 N 144 34x54 G.S1 E 35 G.S1.01
Polar TM7 G 389 7x41 G.S6 Y 321 G.S6.02
Hydrophobic ICL2 Y 143 34x53 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 Y 143 34x53 G.hns1 R 34 G.hns1.03
Hydrophobic ICL3 L 230 - G.H5 A 339 G.H5.10
Polar ICL2 P 140 34x50 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 P 140 34x50 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 P 140 34x50 G.hns1 R 34 G.hns1.03
Polar TM3 R 133 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM2 N 70 2x40 G.H5 L 354 G.H5.25
Van-der-waals TM2 N 70 2x40 G.H5 L 354 G.H5.25
Ionic TM7 L 388 7x40 G.h4s6 E 317 G.h4s6.12
Polar TM7 L 388 7x40 G.h4s6 E 317 G.h4s6.12
Van-der-waals TM7 L 388 7x40 G.h4s6 E 317 G.h4s6.12
Ionic TM7 G 389 7x41 G.H5 R 350 G.H5.21
Polar TM7 G 389 7x41 G.H5 R 350 G.H5.21
Hydrophobic TM7 G 389 7x41 G.H5 R 350 G.H5.21
Van-der-waals TM7 G 389 7x41 G.H5 R 350 G.H5.21
Hydrophobic ICL1 L 65 12x50 G.H5 L 354 G.H5.25
Van-der-waals ICL1 L 65 12x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 141 34x51 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 L 141 34x51 G.s2s3 N 194 G.s2s3.02
Polar ICL2 N 144 34x54 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 N 144 34x54 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 N 144 34x54 G.hns1 R 34 G.hns1.03
Hydrophobic TM5 R 226 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM7 T 386 7x38 G.h4s6 V 319 G.h4s6.20
Hydrophobic ICL1 A 64 12x49 G.h3s5 N 262 G.h3s5.02
Van-der-waals ICL1 A 64 12x49 G.h3s5 N 262 G.h3s5.02
Hydrophobic ICL2 L 141 34x51 G.S2 L 192 G.S2.08
Van-der-waals ICL2 L 141 34x51 G.S2 L 192 G.S2.08
Polar TM3 R 133 3x50 G.H5 N 353 G.H5.24
Hydrophobic TM3 R 133 3x50 G.H5 N 353 G.H5.24
Van-der-waals TM3 R 133 3x50 G.H5 N 353 G.H5.24
Hydrophobic ICL2 L 141 34x51 G.H5 L 345 G.H5.16
Hydrophobic ICL2 L 141 34x51 G.S3 I 195 G.S3.01
Van-der-waals ICL2 L 141 34x51 G.S3 I 195 G.S3.01
Hydrophobic TM7 L 395 7x48 G.H5 L 354 G.H5.25
Van-der-waals TM7 L 395 7x48 G.H5 L 354 G.H5.25
Hydrophobic TM2 I 73 2x43 G.H5 V 355 G.H5.26
Van-der-waals TM2 I 73 2x43 G.H5 V 355 G.H5.26
Hydrophobic TM2 T 67 2x37 G.H5 F 352 G.H5.23
Polar TM7 N 392 7x45 G.H5 N 353 G.H5.24
Hydrophobic TM7 N 392 7x45 G.H5 N 353 G.H5.24
Hydrophobic TM7 N 396 7x49 G.H5 V 355 G.H5.26
Van-der-waals TM7 N 396 7x49 G.H5 V 355 G.H5.26
Polar TM5 R 226 5x72 G.H5 Q 346 G.H5.17
Van-der-waals TM5 R 226 5x72 G.H5 Q 346 G.H5.17
Hydrophobic TM7 N 392 7x45 G.H5 R 350 G.H5.21
Hydrophobic ICL2 R 145 34x55 G.S3 I 196 G.S3.02
Van-der-waals ICL2 R 145 34x55 G.S3 I 196 G.S3.02
Van-der-waals TM2 T 69 2x39 G.H5 V 355 G.H5.26
Hydrophobic TM3 A 136 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 A 136 3x53 G.H5 L 349 G.H5.20
Polar ICL2 R 145 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 145 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 145 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM2 P 68 2x38 G.H5 F 352 G.H5.23
Van-der-waals TM2 P 68 2x38 G.H5 F 352 G.H5.23
Hydrophobic ICL2 N 144 34x54 G.H5 F 352 G.H5.23
Van-der-waals ICL2 N 144 34x54 G.H5 F 352 G.H5.23
Ionic ICL2 R 145 34x55 G.S2 D 191 G.S2.07
Polar ICL2 R 145 34x55 G.S2 D 191 G.S2.07
Hydrophobic ICL2 R 145 34x55 G.S2 D 191 G.S2.07
Van-der-waals ICL2 R 145 34x55 G.S2 D 191 G.S2.07
Polar TM2 T 69 2x39 G.H5 F 352 G.H5.23
Hydrophobic TM2 T 69 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 T 69 2x39 G.H5 F 352 G.H5.23
Hydrophobic ICL2 L 141 34x51 G.s2s3 E 193 G.s2s3.01
Van-der-waals ICL2 L 141 34x51 G.s2s3 E 193 G.s2s3.01
Ionic TM5 K 229 5x75 G.H5 D 342 G.H5.13