Gs - D4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 W 222 5x68 G.H5 L 394 G.H5.26
Polar TM3 V 137 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 137 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 140 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 140 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 N 144 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 W 222 5x68 G.H5 L 388 G.H5.20
Polar ICL3 R 233 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 R 233 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 R 233 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 P 140 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 140 34x50 G.H5 H 387 G.H5.19
Polar ICL3 R 233 - G.S6 P 361 G.S6.03
Hydrophobic ICL3 R 233 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 R 233 - G.S6 P 361 G.S6.03
Hydrophobic ICL2 L 141 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 R 145 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 145 34x55 G.hns1 A 39 G.hns1.03
Polar ICL2 N 144 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 N 144 34x54 G.H5 H 387 G.H5.19
Van-der-waals ICL2 N 144 34x54 G.H5 H 387 G.H5.19
Ionic TM7 P 378 7x30 G.hgh4 D 323 G.hgh4.13
Polar TM7 P 378 7x30 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM7 P 378 7x30 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM7 P 378 7x30 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM7 N 392 7x45 G.H5 L 394 G.H5.26
Van-der-waals TM7 N 392 7x45 G.H5 L 394 G.H5.26
Ionic ICL3 R 236 - G.hgh4 E 322 G.hgh4.12
Polar ICL3 R 236 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 R 236 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 R 236 - G.hgh4 E 322 G.hgh4.12
Polar ICL3 G 232 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 G 232 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 G 232 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 R 142 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 L 219 5x65 G.H5 L 393 G.H5.25
Polar TM7 L 381 7x33 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM7 L 381 7x33 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 L 230 - G.h4s6 Y 358 G.h4s6.20
Polar ICL2 R 142 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 142 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM7 N 392 7x45 G.H5 L 393 G.H5.25
Van-der-waals TM7 N 392 7x45 G.H5 L 393 G.H5.25
Polar TM5 W 222 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 W 222 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 W 222 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 G 147 34x57 G.HN Q 35 G.HN.52
Hydrophobic TM7 G 389 7x41 G.H5 L 394 G.H5.26
Van-der-waals TM7 G 389 7x41 G.H5 L 394 G.H5.26
Hydrophobic TM7 N 396 7x49 G.H5 L 393 G.H5.25
Van-der-waals TM7 N 396 7x49 G.H5 L 393 G.H5.25
Hydrophobic TM7 L 388 7x40 G.H5 L 394 G.H5.26
Van-der-waals TM7 L 388 7x40 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 141 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 141 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM7 L 395 7x48 G.H5 E 392 G.H5.24
Polar ICL2 L 141 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 141 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 141 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM2 T 67 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 T 67 2x37 G.H5 Q 390 G.H5.22
Polar TM7 S 393 7x46 G.H5 L 393 G.H5.25
Hydrophobic TM7 S 393 7x46 G.H5 L 393 G.H5.25
Van-der-waals TM7 S 393 7x46 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 140 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 140 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 226 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 R 226 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 141 34x51 G.S3 V 217 G.S3.01
Polar ICL2 Y 143 34x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 143 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 143 34x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 140 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 R 380 G.H5.12
Polar ICL3 G 232 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 G 232 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 G 232 - G.H4 R 342 G.H4.12
Ionic TM7 G 389 7x41 G.H5 R 385 G.H5.17
Polar TM7 G 389 7x41 G.H5 R 385 G.H5.17
Hydrophobic TM7 G 389 7x41 G.H5 R 385 G.H5.17
Van-der-waals TM7 G 389 7x41 G.H5 R 385 G.H5.17
Polar TM2 T 69 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 69 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 69 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 L 393 G.H5.25
Van-der-waals ICL3 H 231 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 T 215 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 N 144 34x54 G.hns1 R 38 G.hns1.02
Aromatic ICL2 Y 143 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 143 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 143 34x53 G.H5 H 387 G.H5.19
Polar TM5 W 222 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 W 222 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 W 222 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL3 R 233 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 R 233 - G.S6 Y 360 G.S6.02
Polar TM3 A 136 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 136 3x53 G.H5 H 387 G.H5.19
Ionic TM5 K 229 5x75 G.H5 D 378 G.H5.10
Polar TM5 K 229 5x75 G.H5 D 378 G.H5.10
Hydrophobic TM5 W 222 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 141 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 141 34x51 G.H5 F 376 G.H5.08
Ionic TM5 R 226 5x72 G.H5 D 381 G.H5.13
Hydrophobic TM5 R 226 5x72 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 226 5x72 G.H5 D 381 G.H5.13
Aromatic TM5 R 226 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 226 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 226 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 R 233 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 R 233 - G.H4 L 346 G.H4.16
Hydrophobic TM3 V 137 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 137 3x54 G.H5 L 388 G.H5.20
Van-der-waals ICL2 R 145 34x55 G.S2 Q 213 G.S2.07
Polar ICL2 N 144 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 N 144 34x54 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 N 144 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 141 34x51 G.S3 F 219 G.S3.03
Ionic ICL3 R 233 - G.H5 D 378 G.H5.10
Polar TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM7 N 392 7x45 G.H5 E 392 G.H5.24
Van-der-waals TM7 N 392 7x45 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 137 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL3 P 235 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 P 235 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 P 235 - G.H4 L 346 G.H4.16
Polar TM7 L 381 7x33 G.h4s6 A 351 G.h4s6.04
Van-der-waals TM7 L 381 7x33 G.h4s6 A 351 G.h4s6.04
Polar ICL2 R 145 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 R 145 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 145 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM3 A 136 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 136 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM7 T 386 7x38 G.h4s6 G 355 G.h4s6.11
Polar ICL3 R 233 - G.S6 H 362 G.S6.04
Aromatic ICL3 R 233 - G.S6 H 362 G.S6.04
Hydrophobic ICL3 R 233 - G.S6 H 362 G.S6.04
Van-der-waals ICL3 R 233 - G.S6 H 362 G.S6.04
Hydrophobic ICL2 L 141 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 L 219 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 219 5x65 G.H5 L 388 G.H5.20