G13 - GPR137 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 69.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 24.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals ECL2 Y 207 - G.H5 N 370 G.H5.19
Polar TM1 Y 58 1x55 G.H5 M 375 G.H5.24
Hydrophobic TM1 Y 58 1x55 G.H5 M 375 G.H5.24
Van-der-waals TM1 Y 58 1x55 G.H5 M 375 G.H5.24
Hydrophobic ECL2 T 204 - G.H5 N 370 G.H5.19
Van-der-waals ECL2 T 204 - G.H5 N 370 G.H5.19
Hydrophobic C-term C 407 - G.s4h3 M 257 G.s4h3.09
Van-der-waals C-term C 407 - G.s4h3 M 257 G.s4h3.09
Hydrophobic C-term S 411 - H.hdhe F 168 H.hdhe.01
Hydrophobic TM7 L 386 7x56 G.H2 F 234 G.H2.08
Hydrophobic TM1 H 53 1x50 G.H5 H 368 G.H5.17
Hydrophobic ECL2 P 202 - G.HN T 43 G.HN.52
Van-der-waals ECL2 P 202 - G.HN T 43 G.HN.52
Polar C-term S 411 - H.HA A 102 H.HA.25
Hydrophobic C-term S 411 - H.HA A 102 H.HA.25
Van-der-waals C-term S 411 - H.HA A 102 H.HA.25
Polar ECL3 T 356 - G.H3 R 279 G.H3.16
Hydrophobic ECL3 T 356 - G.H3 R 279 G.H3.16
Van-der-waals ECL3 T 356 - G.H3 R 279 G.H3.16
Hydrophobic C-term C 409 - H.HA K 94 H.HA.17
Van-der-waals C-term C 409 - H.HA K 94 H.HA.17
Hydrophobic TM7 P 378 7x48 G.S2 H 207 G.S2.02
Hydrophobic TM6 D 347 6x50 G.H4 R 331 G.H4.16
Van-der-waals TM6 D 347 6x50 G.H4 R 331 G.H4.16
Hydrophobic ECL1 F 117 - G.H5 L 374 G.H5.23
Van-der-waals ECL1 F 117 - G.H5 L 374 G.H5.23
Polar ECL2 S 205 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL2 S 205 - G.hns1 R 47 G.hns1.03
Hydrophobic C-term V 414 - G.s4h3 V 255 G.s4h3.07
Van-der-waals C-term V 414 - G.s4h3 V 255 G.s4h3.07
Hydrophobic C-term L 413 - H.HA K 105 H.HA.28
Van-der-waals C-term L 413 - H.HA K 105 H.HA.28
Hydrophobic C-term W 402 - G.s4h3 D 259 G.s4h3.11
Hydrophobic TM1 Y 58 1x55 G.H5 L 376 G.H5.25
Van-der-waals TM1 Y 58 1x55 G.H5 L 376 G.H5.25
Hydrophobic TM7 V 384 7x54 G.H2 F 234 G.H2.08
Van-der-waals TM7 V 384 7x54 G.H2 F 234 G.H2.08
Hydrophobic ECL2 P 202 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL2 P 202 - G.hns1 R 47 G.hns1.03
Polar TM4 R 199 4x64 G.hns1 R 47 G.hns1.03
Van-der-waals TM4 R 199 4x64 G.hns1 R 47 G.hns1.03
Polar TM6 T 343 6x46 G.H4 R 331 G.H4.16
Van-der-waals TM6 T 343 6x46 G.H4 R 331 G.H4.16
Hydrophobic ECL1 K 123 - G.H5 L 376 G.H5.25
Van-der-waals ECL1 K 123 - G.H5 L 376 G.H5.25
Hydrophobic TM6 A 349 6x52 G.h4s6 Q 338 G.h4s6.12
Hydrophobic C-term V 414 - H.hdhe F 168 H.hdhe.01
Hydrophobic C-term P 405 - G.s4h3 E 258 G.s4h3.10
Hydrophobic TM7 C 382 7x52 G.H2 E 235 G.H2.09
Polar C-term V 414 - H.HD E 167 H.HD.12
Hydrophobic C-term V 414 - H.HD E 167 H.HD.12
Van-der-waals C-term V 414 - H.HD E 167 H.HD.12
Polar TM3 R 128 3x26 G.HN K 42 G.HN.51
Hydrophobic TM3 R 128 3x26 G.HN K 42 G.HN.51
Van-der-waals TM3 R 128 3x26 G.HN K 42 G.HN.51
Hydrophobic ECL2 K 211 - G.H5 K 363 G.H5.12
Van-der-waals ECL2 K 211 - G.H5 K 363 G.H5.12
Hydrophobic ECL2 A 210 - G.H5 F 359 G.H5.08
Van-der-waals ECL2 A 210 - G.H5 F 359 G.H5.08
Hydrophobic ECL2 Y 207 - G.H5 I 366 G.H5.15
Hydrophobic C-term H 410 - H.HB M 123 H.HB.10
Van-der-waals C-term H 410 - H.HB M 123 H.HB.10
Hydrophobic C-term L 413 - H.HA L 106 H.HA.29
Van-der-waals C-term L 413 - H.HA L 106 H.HA.29
Hydrophobic ECL2 I 206 - G.S1 V 49 G.S1.02
Van-der-waals ECL2 I 206 - G.S1 V 49 G.S1.02
Polar TM1 S 57 1x54 G.H5 M 375 G.H5.24
Hydrophobic TM1 S 57 1x54 G.H5 M 375 G.H5.24
Van-der-waals TM1 S 57 1x54 G.H5 M 375 G.H5.24
Polar TM6 D 347 6x50 G.h4s6 Q 337 G.h4s6.11
Hydrophobic TM6 D 347 6x50 G.h4s6 Q 337 G.h4s6.11
Van-der-waals TM6 D 347 6x50 G.h4s6 Q 337 G.h4s6.11
Ionic C-term E 412 - G.s4h3 R 260 G.s4h3.12
Polar C-term E 412 - G.s4h3 R 260 G.s4h3.12
Hydrophobic C-term E 412 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term E 412 - G.s4h3 R 260 G.s4h3.12
Ionic TM6 E 341 6x44 G.H4 R 320 G.H4.05
Polar TM6 E 341 6x44 G.H4 R 320 G.H4.05
Hydrophobic TM6 E 341 6x44 G.H4 R 320 G.H4.05
Van-der-waals TM6 E 341 6x44 G.H4 R 320 G.H4.05
Hydrophobic C-term E 412 - H.hdhe F 168 H.hdhe.01
Polar TM6 T 343 6x46 G.S6 H 344 G.S6.03
Hydrophobic TM6 T 343 6x46 G.S6 H 344 G.S6.03
Van-der-waals TM6 T 343 6x46 G.S6 H 344 G.S6.03
Hydrophobic TM6 A 349 6x52 G.h4s6 Q 337 G.h4s6.11
Hydrophobic C-term C 406 - G.s4h3 M 257 G.s4h3.09
Van-der-waals C-term C 406 - G.s4h3 M 257 G.s4h3.09
Polar ECL1 A 124 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL1 A 124 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL1 A 124 - G.hns1 K 46 G.hns1.02
Polar ECL2 Y 207 - G.H5 L 367 G.H5.16
Hydrophobic ECL2 Y 207 - G.H5 L 367 G.H5.16
Van-der-waals ECL2 Y 207 - G.H5 L 367 G.H5.16
Polar ECL1 Y 116 - G.H5 M 375 G.H5.24
Hydrophobic ECL1 Y 116 - G.H5 M 375 G.H5.24
Van-der-waals ECL1 Y 116 - G.H5 M 375 G.H5.24
Hydrophobic ECL1 V 120 - G.H5 L 374 G.H5.23
Van-der-waals ECL1 V 120 - G.H5 L 374 G.H5.23
Hydrophobic C-term C 409 - H.HB T 127 H.HB.14
Van-der-waals C-term C 409 - H.HB T 127 H.HB.14
Polar ECL2 S 203 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 S 203 - G.hns1 K 46 G.hns1.02
Ionic C-term H 410 - H.HA D 101 H.HA.24
Polar C-term H 410 - H.HA D 101 H.HA.24
Hydrophobic C-term H 410 - H.HA D 101 H.HA.24
Van-der-waals C-term H 410 - H.HA D 101 H.HA.24
Hydrophobic TM3 R 128 3x26 G.hns1 K 46 G.hns1.02
Van-der-waals TM3 R 128 3x26 G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 K 211 - G.H5 L 367 G.H5.16
Van-der-waals ECL2 K 211 - G.H5 L 367 G.H5.16
Hydrophobic ECL2 I 206 - G.S3 V 216 G.S3.01
Van-der-waals ECL2 I 206 - G.S3 V 216 G.S3.01
Polar C-term S 411 - H.HA D 101 H.HA.24
Hydrophobic C-term S 411 - H.HA D 101 H.HA.24
Van-der-waals C-term S 411 - H.HA D 101 H.HA.24
Hydrophobic TM7 L 381 7x51 G.S2 I 206 G.S2.01
Hydrophobic TM7 L 381 7x51 G.S2 E 208 G.S2.03
Polar TM6 C 345 6x48 G.H4 R 331 G.H4.16
Hydrophobic TM6 C 345 6x48 G.H4 R 331 G.H4.16
Van-der-waals TM6 C 345 6x48 G.H4 R 331 G.H4.16
Hydrophobic ECL1 V 120 - G.H5 Q 373 G.H5.22
Van-der-waals ECL1 V 120 - G.H5 Q 373 G.H5.22
Van-der-waals C-term L 413 - H.HD E 167 H.HD.12
Hydrophobic ECL2 A 201 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL1 Y 116 - G.H5 L 374 G.H5.23
Van-der-waals ECL1 Y 116 - G.H5 L 374 G.H5.23
Hydrophobic C-term C 409 - H.HA R 97 H.HA.20
Van-der-waals C-term C 409 - H.HA R 97 H.HA.20
Hydrophobic ECL2 I 206 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL2 I 206 - G.hns1 R 47 G.hns1.03
Polar ECL2 A 210 - G.H5 K 363 G.H5.12
Hydrophobic ECL2 A 210 - G.H5 K 363 G.H5.12
Van-der-waals ECL2 A 210 - G.H5 K 363 G.H5.12
Hydrophobic ECL1 Q 119 - G.H5 L 376 G.H5.25
Van-der-waals ECL1 Q 119 - G.H5 L 376 G.H5.25
Hydrophobic ECL2 R 200 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 R 200 - G.hns1 K 46 G.hns1.02
Hydrophobic C-term L 413 - H.hdhe F 168 H.hdhe.01
Hydrophobic TM6 R 344 6x47 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 R 344 6x47 G.h4s6 P 341 G.h4s6.20
Ionic TM6 D 347 6x50 G.h4s6 R 334 G.h4s6.08
Polar C-term S 411 - H.HA V 98 H.HA.21
Hydrophobic C-term S 411 - H.HA V 98 H.HA.21
Van-der-waals C-term S 411 - H.HA V 98 H.HA.21
Polar C-term S 411 - H.HA K 105 H.HA.28
Hydrophobic C-term S 411 - H.HA K 105 H.HA.28
Van-der-waals C-term S 411 - H.HA K 105 H.HA.28
Polar TM6 Q 348 6x51 G.h4s6 Q 337 G.h4s6.11
Hydrophobic TM6 Q 348 6x51 G.h4s6 Q 337 G.h4s6.11
Van-der-waals TM6 Q 348 6x51 G.h4s6 Q 337 G.h4s6.11
Hydrophobic TM1 Q 59 1x56 G.H5 M 375 G.H5.24
Van-der-waals TM1 Q 59 1x56 G.H5 M 375 G.H5.24
Polar ECL2 P 202 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 P 202 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 P 202 - G.hns1 K 46 G.hns1.02
Hydrophobic C-term P 417 - G.hgh4 Y 308 G.hgh4.01
Polar ECL1 K 123 - G.H5 Q 373 G.H5.22
Hydrophobic ECL1 K 123 - G.H5 Q 373 G.H5.22
Van-der-waals ECL1 K 123 - G.H5 Q 373 G.H5.22
Polar TM1 K 54 1x51 G.H5 Q 377 G.H5.26
Hydrophobic TM1 K 54 1x51 G.H5 Q 377 G.H5.26
Van-der-waals TM1 K 54 1x51 G.H5 Q 377 G.H5.26
Hydrophobic ECL2 S 203 - G.H5 I 366 G.H5.15
Van-der-waals ECL2 S 203 - G.H5 I 366 G.H5.15
Polar C-term C 409 - H.HA V 98 H.HA.21
Hydrophobic C-term C 409 - H.HA V 98 H.HA.21