Gi2 - GPR137 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 69.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ECL2 I 206 - G.S1 V 34 G.S1.02
Van-der-waals ECL2 I 206 - G.S1 V 34 G.S1.02
Hydrophobic TM6 D 330 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 D 330 6x33 G.H5 L 349 G.H5.20
Polar ECL2 S 203 - G.H5 N 348 G.H5.19
Hydrophobic ECL2 S 203 - G.H5 N 348 G.H5.19
Van-der-waals ECL2 S 203 - G.H5 N 348 G.H5.19
Ionic ECL1 K 123 - G.H5 D 351 G.H5.22
Polar ECL1 K 123 - G.H5 D 351 G.H5.22
Hydrophobic ECL1 K 123 - G.H5 D 351 G.H5.22
Van-der-waals ECL1 K 123 - G.H5 D 351 G.H5.22
Hydrophobic ECL1 K 123 - G.H5 C 352 G.H5.23
Polar TM4 A 198 4x63 G.hns1 R 32 G.hns1.03
Polar ECL1 V 120 - G.H5 C 352 G.H5.23
Hydrophobic ECL1 V 120 - G.H5 C 352 G.H5.23
Van-der-waals ECL1 V 120 - G.H5 C 352 G.H5.23
Hydrophobic ECL2 R 200 - G.HN E 28 G.HN.52
Van-der-waals ECL2 R 200 - G.HN E 28 G.HN.52
Hydrophobic ECL2 P 202 - G.hns1 A 30 G.hns1.01
Van-der-waals ECL2 P 202 - G.hns1 A 30 G.hns1.01
Hydrophobic ECL2 R 200 - G.hns1 A 31 G.hns1.02
Polar ECL2 S 203 - G.hns1 A 31 G.hns1.02
Polar ECL2 P 202 - G.S1 E 33 G.S1.01
Hydrophobic ECL2 P 202 - G.S1 E 33 G.S1.01
Van-der-waals ECL2 P 202 - G.S1 E 33 G.S1.01
Hydrophobic TM6 W 335 6x38 G.H5 A 339 G.H5.10
Van-der-waals TM6 W 335 6x38 G.H5 A 339 G.H5.10
Hydrophobic TM1 Q 59 1x56 G.H5 F 355 G.H5.26
Van-der-waals TM1 Q 59 1x56 G.H5 F 355 G.H5.26
Ionic ECL1 K 123 - G.h3s5 D 262 G.h3s5.02
Polar ECL1 K 123 - G.h3s5 D 262 G.h3s5.02
Polar ECL1 Y 116 - G.H5 L 354 G.H5.25
Hydrophobic ECL1 Y 116 - G.H5 L 354 G.H5.25
Van-der-waals ECL1 Y 116 - G.H5 L 354 G.H5.25
Hydrophobic ECL2 R 200 - G.HN G 27 G.HN.51
Polar TM6 C 333 6x36 G.H5 D 342 G.H5.13
Hydrophobic TM6 C 333 6x36 G.H5 D 342 G.H5.13
Hydrophobic ECL2 A 210 - G.H5 I 345 G.H5.16
Van-der-waals ECL2 A 210 - G.H5 I 345 G.H5.16
Hydrophobic ECL2 T 204 - G.H5 C 352 G.H5.23
Van-der-waals ECL2 T 204 - G.H5 C 352 G.H5.23
Hydrophobic ECL1 F 117 - G.H5 L 354 G.H5.25
Hydrophobic TM6 H 327 6x30 G.H5 L 354 G.H5.25
Van-der-waals TM6 H 327 6x30 G.H5 L 354 G.H5.25
Hydrophobic ECL2 I 206 - G.S3 L 195 G.S3.01
Van-der-waals ECL2 I 206 - G.S3 L 195 G.S3.01
Hydrophobic ECL2 E 209 - G.s2s3 D 194 G.s2s3.02
Van-der-waals ECL2 E 209 - G.s2s3 D 194 G.s2s3.02
Polar ECL1 Q 119 - G.H5 D 351 G.H5.22
Hydrophobic ECL2 P 202 - G.hns1 R 32 G.hns1.03
Van-der-waals ECL2 P 202 - G.hns1 R 32 G.hns1.03
Hydrophobic ECL2 I 206 - G.S1 E 33 G.S1.01
Van-der-waals ECL2 I 206 - G.S1 E 33 G.S1.01
Hydrophobic ECL2 Y 207 - G.H5 L 354 G.H5.25
Hydrophobic TM6 G 326 6x29 G.H5 L 354 G.H5.25
Hydrophobic ECL2 A 201 - G.hns1 A 31 G.hns1.02
Van-der-waals ECL2 A 201 - G.hns1 A 31 G.hns1.02
Hydrophobic ECL2 T 204 - G.H5 N 348 G.H5.19
Polar TM1 K 54 1x51 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM1 K 54 1x51 G.h4s6 T 317 G.h4s6.10
Van-der-waals TM1 K 54 1x51 G.h4s6 T 317 G.h4s6.10
Hydrophobic ECL2 P 202 - G.HN K 29 G.HN.53
Van-der-waals ECL2 P 202 - G.HN K 29 G.HN.53
Hydrophobic ECL1 Y 116 - G.H5 G 353 G.H5.24
Van-der-waals ECL1 Y 116 - G.H5 G 353 G.H5.24
Hydrophobic ECL2 Y 207 - G.H5 I 345 G.H5.16
Van-der-waals ECL2 Y 207 - G.H5 I 345 G.H5.16
Polar TM3 K 127 3x25 G.h2s4 G 218 G.h2s4.03
Van-der-waals TM3 K 127 3x25 G.h2s4 G 218 G.h2s4.03
Ionic ECL2 E 209 - G.hns1 R 32 G.hns1.03
Polar ECL2 E 209 - G.hns1 R 32 G.hns1.03
Hydrophobic ECL2 E 209 - G.hns1 R 32 G.hns1.03
Van-der-waals ECL2 E 209 - G.hns1 R 32 G.hns1.03
Polar TM3 R 128 3x26 G.hns1 A 30 G.hns1.01
Hydrophobic TM3 R 128 3x26 G.hns1 A 30 G.hns1.01
Van-der-waals TM3 R 128 3x26 G.hns1 A 30 G.hns1.01
Hydrophobic ECL2 Y 207 - G.H5 L 349 G.H5.20
Van-der-waals ECL2 Y 207 - G.H5 L 349 G.H5.20
Polar TM3 R 128 3x26 G.HN D 26 G.HN.50
Van-der-waals TM3 R 128 3x26 G.HN D 26 G.HN.50
Hydrophobic TM3 R 128 3x26 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 R 128 3x26 G.hns1 A 31 G.hns1.02
Polar ECL1 Q 119 - G.H5 C 352 G.H5.23
Hydrophobic ECL1 Q 119 - G.H5 C 352 G.H5.23
Van-der-waals ECL1 Q 119 - G.H5 C 352 G.H5.23
Polar TM3 K 127 3x25 G.h2s4 V 219 G.h2s4.04
Polar ECL2 P 202 - G.hns1 A 31 G.hns1.02
Hydrophobic ECL2 P 202 - G.hns1 A 31 G.hns1.02
Van-der-waals ECL2 P 202 - G.hns1 A 31 G.hns1.02
Hydrophobic ECL1 Y 116 - G.H5 C 352 G.H5.23
Van-der-waals ECL1 Y 116 - G.H5 C 352 G.H5.23
Hydrophobic ECL2 P 202 - G.HN E 28 G.HN.52
Van-der-waals ECL2 P 202 - G.HN E 28 G.HN.52
Polar ECL2 A 210 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ECL2 A 210 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ECL2 A 210 - G.s2s3 K 193 G.s2s3.01
Van-der-waals TM4 R 199 4x64 G.HN R 24 G.HN.48
Hydrophobic TM1 Y 58 1x55 G.H5 G 353 G.H5.24
Van-der-waals TM1 Y 58 1x55 G.H5 G 353 G.H5.24
Polar TM1 S 57 1x54 G.H5 F 355 G.H5.26
Hydrophobic TM1 S 57 1x54 G.H5 F 355 G.H5.26
Van-der-waals TM1 S 57 1x54 G.H5 F 355 G.H5.26
Hydrophobic TM3 R 128 3x26 G.HN G 27 G.HN.51
Van-der-waals TM3 R 128 3x26 G.HN G 27 G.HN.51
Hydrophobic ECL2 P 202 - G.HN G 27 G.HN.51
Van-der-waals ECL2 P 202 - G.HN G 27 G.HN.51
Aromatic TM6 W 335 6x38 G.H5 F 335 G.H5.06
Hydrophobic TM6 W 335 6x38 G.H5 F 335 G.H5.06
Van-der-waals TM6 W 335 6x38 G.H5 F 335 G.H5.06
Polar ECL2 S 205 - G.hns1 R 32 G.hns1.03
Hydrophobic ECL2 S 205 - G.hns1 R 32 G.hns1.03
Van-der-waals ECL2 S 205 - G.hns1 R 32 G.hns1.03
Hydrophobic TM4 R 199 4x64 G.HN E 28 G.HN.52
Van-der-waals TM4 R 199 4x64 G.HN E 28 G.HN.52
Hydrophobic TM6 D 330 6x33 G.H5 F 355 G.H5.26
Van-der-waals TM6 D 330 6x33 G.H5 F 355 G.H5.26
Hydrophobic ECL2 A 210 - G.S3 L 195 G.S3.01
Hydrophobic TM1 H 53 1x50 G.H5 F 355 G.H5.26
Van-der-waals TM1 H 53 1x50 G.H5 F 355 G.H5.26
Van-der-waals ECL2 V 215 - G.hns1 R 32 G.hns1.03
Hydrophobic ECL2 I 206 - G.hns1 R 32 G.hns1.03
Van-der-waals ECL2 I 206 - G.hns1 R 32 G.hns1.03