G15 - GLP-1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 20.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 259 - G.HN Q 35 G.HN.50
Van-der-waals ICL2 V 259 - G.HN Q 35 G.HN.50
Polar TM5 N 338 5x68 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM5 N 338 5x68 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 E 418 8x59 G.H3 W 266 G.H3.17
Hydrophobic H8 K 415 8x56 G.H3 P 265 G.H3.16
Hydrophobic TM5 K 334 5x64 G.H5 L 373 G.H5.25
Van-der-waals TM5 K 334 5x64 G.H5 L 373 G.H5.25
Hydrophobic ICL2 S 258 - G.HN I 28 G.HN.43
Hydrophobic ICL2 S 258 - G.HN L 32 G.HN.47
Van-der-waals ICL2 S 258 - G.HN L 32 G.HN.47
Ionic H8 D 430 8x71 G.H2 K 217 G.H2.05
Polar H8 D 430 8x71 G.H2 K 217 G.H2.05
Van-der-waals H8 D 430 8x71 G.H2 K 217 G.H2.05
Ionic H8 R 419 8x60 G.h2s4 E 224 G.h2s4.02
Polar H8 R 419 8x60 G.h2s4 E 224 G.h2s4.02
Hydrophobic H8 R 419 8x60 G.h2s4 E 224 G.h2s4.02
Van-der-waals H8 R 419 8x60 G.h2s4 E 224 G.h2s4.02
Polar ICL1 H 171 12x49 G.h2s4 N 225 G.h2s4.03
Hydrophobic ICL1 H 171 12x49 G.h2s4 N 225 G.h2s4.03
Van-der-waals ICL1 H 171 12x49 G.h2s4 N 225 G.h2s4.03
Hydrophobic H8 R 419 8x60 G.H3 W 266 G.H3.17
Hydrophobic H8 E 418 8x59 G.H2 I 220 G.H2.08
Hydrophobic H8 R 414 8x55 G.H3 P 265 G.H3.16
Hydrophobic H8 L 411 8x52 G.H3 P 265 G.H3.16
Van-der-waals H8 L 411 8x52 G.H3 P 265 G.H3.16
Hydrophobic TM6 R 348 6x37 G.h4s6 K 332 G.h4s6.14
Van-der-waals TM6 R 348 6x37 G.h4s6 K 332 G.h4s6.14
Hydrophobic ICL2 V 259 - G.HN I 31 G.HN.46
Hydrophobic H8 L 422 8x63 G.H2 I 220 G.H2.08
Van-der-waals H8 L 422 8x63 G.H2 I 220 G.H2.08
Polar H8 H 426 8x67 G.H2 K 217 G.H2.05
Hydrophobic H8 H 426 8x67 G.H2 K 217 G.H2.05
Van-der-waals H8 H 426 8x67 G.H2 K 217 G.H2.05
Ionic H8 K 415 8x56 G.h2s4 E 224 G.h2s4.02
Polar H8 K 415 8x56 G.h2s4 E 224 G.h2s4.02
Hydrophobic H8 K 415 8x56 G.h2s4 E 224 G.h2s4.02
Van-der-waals H8 K 415 8x56 G.h2s4 E 224 G.h2s4.02
Hydrophobic H8 K 415 8x56 G.H3 W 266 G.H3.17
Van-der-waals H8 K 415 8x56 G.H3 W 266 G.H3.17
Polar H8 R 419 8x60 G.H2 I 220 G.H2.08
Hydrophobic H8 R 419 8x60 G.H2 I 220 G.H2.08
Van-der-waals H8 R 419 8x60 G.H2 I 220 G.H2.08