G13 - GLP-2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 72.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 295 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 P 295 - G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 V 293 - G.H5 F 359 G.H5.08
Polar TM3 L 288 3x57 G.H5 N 370 G.H5.19
Hydrophobic TM3 L 288 3x57 G.H5 N 370 G.H5.19
Van-der-waals TM3 L 288 3x57 G.H5 N 370 G.H5.19
Hydrophobic C-term L 530 - H.HA E 104 H.HA.27
Polar C-term S 531 - G.s4h3 R 260 G.s4h3.12
Hydrophobic C-term S 531 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term S 531 - G.s4h3 R 260 G.s4h3.12
Polar TM3 L 289 3x58 G.H5 K 363 G.H5.12
Hydrophobic TM3 L 289 3x58 G.H5 K 363 G.H5.12
Van-der-waals TM3 L 289 3x58 G.H5 K 363 G.H5.12
Hydrophobic TM5 I 361 5x57 G.H5 L 371 G.H5.20
Hydrophobic TM7 Q 435 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 Q 435 7x56 G.H5 L 376 G.H5.25
Hydrophobic C-term M 544 - G.H2 W 233 G.H2.07
Van-der-waals C-term M 544 - G.H2 W 233 G.H2.07
Hydrophobic TM3 L 289 3x58 G.H5 L 367 G.H5.16
Van-der-waals TM3 L 289 3x58 G.H5 L 367 G.H5.16
Hydrophobic TM3 P 291 3x60 G.H5 F 359 G.H5.08
Polar C-term L 530 - H.HA K 105 H.HA.28
Hydrophobic C-term L 530 - H.HA K 105 H.HA.28
Van-der-waals C-term L 530 - H.HA K 105 H.HA.28
Hydrophobic C-term I 547 - G.H2 K 231 G.H2.05
Van-der-waals C-term I 547 - G.H2 K 231 G.H2.05
Polar TM7 Y 436 7x57 G.H5 L 374 G.H5.23
Hydrophobic TM7 Y 436 7x57 G.H5 L 374 G.H5.23
Van-der-waals TM7 Y 436 7x57 G.H5 L 374 G.H5.23
Hydrophobic TM6 V 389 6x44 G.H5 L 376 G.H5.25
Hydrophobic TM3 L 289 3x58 G.H5 L 371 G.H5.20
Ionic TM5 K 368 5x64 G.H5 D 364 G.H5.13
Polar TM5 K 368 5x64 G.H5 D 364 G.H5.13
Hydrophobic TM5 K 368 5x64 G.H5 D 364 G.H5.13
Van-der-waals TM5 K 368 5x64 G.H5 D 364 G.H5.13
Hydrophobic C-term S 531 - H.HA K 105 H.HA.28
Van-der-waals C-term S 531 - H.HA K 105 H.HA.28
Hydrophobic ICL2 P 295 - G.HN T 43 G.HN.52
Van-der-waals ICL2 P 295 - G.HN T 43 G.HN.52
Hydrophobic TM5 L 364 5x60 G.H5 L 367 G.H5.16
Van-der-waals TM5 L 364 5x60 G.H5 L 367 G.H5.16
Hydrophobic C-term I 547 - G.H2 F 234 G.H2.08
Polar C-term E 532 - G.s4h3 R 260 G.s4h3.12
Hydrophobic ICL2 P 295 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 P 295 - G.hns1 R 47 G.hns1.03
Hydrophobic TM3 L 285 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 L 285 3x54 G.H5 L 374 G.H5.23
Hydrophobic TM5 L 365 5x61 G.H5 M 375 G.H5.24
Polar ICL2 R 298 - G.HN T 43 G.HN.52
Hydrophobic ICL2 R 298 - G.HN T 43 G.HN.52
Van-der-waals ICL2 R 298 - G.HN T 43 G.HN.52
Hydrophobic TM3 P 291 3x60 G.H5 K 363 G.H5.12
Van-der-waals TM3 P 291 3x60 G.H5 K 363 G.H5.12
Hydrophobic TM7 Y 436 7x57 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 436 7x57 G.H5 L 376 G.H5.25
Hydrophobic C-term L 548 - G.H3 T 274 G.H3.11
Van-der-waals C-term L 548 - G.H3 T 274 G.H3.11
Hydrophobic TM6 L 393 6x48 G.H5 L 374 G.H5.23
Van-der-waals TM6 L 393 6x48 G.H5 L 374 G.H5.23
Hydrophobic ICL2 V 293 - G.S1 V 49 G.S1.02
Van-der-waals ICL2 V 293 - G.S1 V 49 G.S1.02
Hydrophobic TM5 L 365 5x61 G.H5 L 371 G.H5.20
Hydrophobic C-term M 544 - G.H2 R 230 G.H2.04
Van-der-waals C-term M 544 - G.H2 R 230 G.H2.04
Hydrophobic C-term L 548 - G.h2s4 F 237 G.h2s4.01
Hydrophobic C-term L 548 - G.H3 N 278 G.H3.15
Van-der-waals C-term L 548 - G.H3 N 278 G.H3.15
Ionic C-term E 552 - G.H3 R 279 G.H3.16
Polar C-term E 552 - G.H3 R 279 G.H3.16
Van-der-waals C-term E 552 - G.H3 R 279 G.H3.16
Hydrophobic TM5 L 364 5x60 G.H5 L 371 G.H5.20
Polar TM7 Q 435 7x56 G.H5 M 375 G.H5.24
Hydrophobic ICL2 V 293 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 V 293 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 294 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 L 294 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 V 293 - G.S3 V 216 G.S3.01
Van-der-waals ICL2 V 293 - G.S3 V 216 G.S3.01
Polar C-term M 540 - G.H2 K 231 G.H2.05
Van-der-waals C-term M 540 - G.H2 K 231 G.H2.05
Hydrophobic TM3 E 290 3x59 G.H5 K 363 G.H5.12
Van-der-waals TM3 E 290 3x59 G.H5 K 363 G.H5.12
Hydrophobic C-term L 530 - H.HB M 123 H.HB.10
Polar TM2 R 210 2x46 G.H5 Q 373 G.H5.22
Hydrophobic TM2 R 210 2x46 G.H5 Q 373 G.H5.22
Van-der-waals TM2 R 210 2x46 G.H5 Q 373 G.H5.22
Hydrophobic H8 N 440 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 N 440 8x47 G.H5 L 376 G.H5.25
Ionic C-term E 532 - H.HA R 97 H.HA.20
Polar C-term E 532 - H.HA R 97 H.HA.20
Van-der-waals C-term E 532 - H.HA R 97 H.HA.20
Hydrophobic H8 G 441 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 G 441 8x48 G.H5 Q 377 G.H5.26
Hydrophobic C-term M 544 - G.H3 T 274 G.H3.11
Hydrophobic ICL2 R 297 - G.HN K 42 G.HN.51
Van-der-waals ICL2 R 297 - G.HN K 42 G.HN.51
Hydrophobic TM6 S 386 6x41 G.H5 M 375 G.H5.24
Van-der-waals TM6 S 386 6x41 G.H5 M 375 G.H5.24
Hydrophobic TM6 V 389 6x44 G.H5 M 375 G.H5.24
Hydrophobic C-term L 530 - H.HA D 101 H.HA.24
Van-der-waals C-term L 530 - H.HA D 101 H.HA.24
Hydrophobic ICL2 R 297 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 297 - G.hns1 K 46 G.hns1.02
Polar H8 G 441 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 G 441 8x48 G.H5 L 376 G.H5.25
Hydrophobic C-term S 529 - H.HA K 105 H.HA.28
Van-der-waals C-term S 529 - H.HA K 105 H.HA.28