G13 - glucagon receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term A 466 - H.HA A 102 H.HA.25
Hydrophobic C-term A 466 - H.hdhe F 168 H.hdhe.01
Hydrophobic ICL2 T 257 - G.S3 V 216 G.S3.01
Van-der-waals ICL2 T 257 - G.S3 V 216 G.S3.01
Hydrophobic ICL2 R 261 - G.HN T 43 G.HN.52
Polar ICL3 R 336 - G.H5 H 368 G.H5.17
Aromatic ICL3 R 336 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 R 336 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 R 336 - G.H5 H 368 G.H5.17
Hydrophobic TM6 T 353 6x44 G.H5 L 376 G.H5.25
Hydrophobic C-term T 463 - H.HA K 94 H.HA.17
Van-der-waals C-term P 464 - G.s4h3 R 260 G.s4h3.12
Hydrophobic C-term A 466 - H.HA V 98 H.HA.21
Hydrophobic TM7 L 399 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 399 7x56 G.H5 L 376 G.H5.25
Hydrophobic TM3 L 255 3x60 G.H5 K 363 G.H5.12
Hydrophobic ICL2 P 259 - G.hns1 R 47 G.hns1.03
Hydrophobic C-term L 469 - H.HD E 167 H.HD.12
Hydrophobic TM3 L 253 3x58 G.H5 L 371 G.H5.20
Hydrophobic H8 N 404 8x47 G.H5 L 376 G.H5.25
Hydrophobic TM6 S 350 6x41 G.H5 M 375 G.H5.24
Van-der-waals TM6 S 350 6x41 G.H5 M 375 G.H5.24
Hydrophobic C-term L 469 - H.HA K 105 H.HA.28
Van-der-waals C-term L 469 - H.HA K 105 H.HA.28
Ionic C-term E 462 - H.hbhc R 128 H.hbhc.01
Polar C-term E 462 - H.hbhc R 128 H.hbhc.01
Van-der-waals C-term E 462 - H.hbhc R 128 H.hbhc.01
Hydrophobic TM3 L 253 3x58 G.H5 L 367 G.H5.16
Van-der-waals TM3 L 253 3x58 G.H5 L 367 G.H5.16
Hydrophobic TM5 L 328 5x60 G.H5 L 367 G.H5.16
Hydrophobic ICL3 R 336 - G.h4s6 P 341 G.h4s6.20
Van-der-waals ICL3 R 336 - G.h4s6 P 341 G.h4s6.20
Hydrophobic C-term L 465 - H.HA D 101 H.HA.24
Van-der-waals C-term L 465 - H.HA D 101 H.HA.24
Hydrophobic ICL2 A 256 - G.H5 F 359 G.H5.08
Van-der-waals ICL2 A 256 - G.H5 F 359 G.H5.08
Hydrophobic TM5 K 332 5x64 G.H5 L 371 G.H5.20
Polar TM3 G 254 3x59 G.H5 K 363 G.H5.12
Van-der-waals TM3 G 254 3x59 G.H5 K 363 G.H5.12
Hydrophobic ICL2 L 258 - G.hns1 R 47 G.hns1.03
Polar C-term A 466 - H.HA D 101 H.HA.24
Hydrophobic C-term A 466 - H.HA D 101 H.HA.24
Van-der-waals C-term A 466 - H.HA D 101 H.HA.24
Polar TM2 T 172 2x45 G.hns1 K 46 G.hns1.02
Ionic ICL3 R 336 - G.H5 D 364 G.H5.13
Polar ICL3 R 336 - G.H5 D 364 G.H5.13
Hydrophobic ICL2 E 260 - G.HN T 43 G.HN.52
Van-der-waals ICL2 E 260 - G.HN T 43 G.HN.52
Polar C-term G 467 - G.s4h3 R 260 G.s4h3.12
Hydrophobic C-term G 467 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term G 467 - G.s4h3 R 260 G.s4h3.12
Hydrophobic TM5 K 332 5x64 G.H5 L 367 G.H5.16
Van-der-waals TM5 K 332 5x64 G.H5 L 367 G.H5.16
Hydrophobic ICL2 L 258 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 L 258 - G.hns1 K 46 G.hns1.02
Hydrophobic H8 K 405 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 K 405 8x48 G.H5 Q 377 G.H5.26
Ionic TM5 K 332 5x64 G.H5 D 364 G.H5.13
Polar TM5 K 332 5x64 G.H5 D 364 G.H5.13
Hydrophobic TM5 K 332 5x64 G.H5 D 364 G.H5.13
Van-der-waals TM5 K 332 5x64 G.H5 D 364 G.H5.13
Ionic ICL2 E 260 - G.hns1 R 47 G.hns1.03
Polar ICL2 E 260 - G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 E 260 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 E 260 - G.hns1 R 47 G.hns1.03
Hydrophobic TM3 L 249 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 L 249 3x54 G.H5 L 374 G.H5.23
Polar ICL3 R 336 - G.S6 Y 343 G.S6.02
Van-der-waals ICL3 R 336 - G.S6 Y 343 G.S6.02
Hydrophobic TM3 L 253 3x58 G.H5 L 374 G.H5.23
Polar TM3 L 252 3x57 G.H5 N 370 G.H5.19
Hydrophobic TM3 L 252 3x57 G.H5 N 370 G.H5.19
Van-der-waals TM3 L 252 3x57 G.H5 N 370 G.H5.19
Hydrophobic ICL2 A 256 - G.H5 K 363 G.H5.12
Van-der-waals ICL2 A 256 - G.H5 K 363 G.H5.12
Hydrophobic TM5 L 328 5x60 G.H5 L 371 G.H5.20
Hydrophobic TM7 Y 400 7x57 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 400 7x57 G.H5 L 376 G.H5.25
Polar TM2 R 173 2x46 G.H5 Q 373 G.H5.22
Van-der-waals TM2 R 173 2x46 G.H5 Q 373 G.H5.22
Polar C-term A 466 - H.HA K 105 H.HA.28
Hydrophobic C-term A 466 - H.HA K 105 H.HA.28
Van-der-waals C-term A 466 - H.HA K 105 H.HA.28
Hydrophobic TM6 L 354 6x45 G.H5 L 374 G.H5.23
Hydrophobic TM3 L 253 3x58 G.H5 N 370 G.H5.19
Hydrophobic C-term L 469 - H.HA L 106 H.HA.29
Van-der-waals C-term L 469 - H.HA L 106 H.HA.29
Hydrophobic ICL2 T 257 - G.S1 V 49 G.S1.02
Hydrophobic TM5 L 329 5x61 G.H5 L 371 G.H5.20
Hydrophobic C-term P 464 - G.s4h3 M 257 G.s4h3.09
Van-der-waals C-term P 464 - G.s4h3 M 257 G.s4h3.09
Hydrophobic C-term L 465 - H.HB M 123 H.HB.10
Van-der-waals C-term L 465 - H.HB M 123 H.HB.10
Van-der-waals C-term G 468 - G.s4h3 R 260 G.s4h3.12
Hydrophobic TM5 L 329 5x61 G.H5 M 375 G.H5.24
Polar C-term L 465 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term L 465 - G.s4h3 R 260 G.s4h3.12
Van-der-waals ICL2 R 261 - G.hns1 R 47 G.hns1.03