G11 - GPR107 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 72.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 27.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 361 - G.H5 L 349 G.H5.16
Van-der-waals ICL2 I 361 - G.H5 L 349 G.H5.16
Van-der-waals TM5 T 483 5x61 G.h3s5 N 266 G.h3s5.02
Hydrophobic ICL2 K 365 - G.H5 V 359 G.H5.26
Van-der-waals ECL2 A 429 - G.h3s5 N 266 G.h3s5.02
Polar TM2 N 289 2x59 G.HN R 30 G.HN.48
Hydrophobic TM2 N 289 2x59 G.HN R 30 G.HN.48
Van-der-waals TM2 N 289 2x59 G.HN R 30 G.HN.48
Hydrophobic ICL2 I 361 - G.H5 L 358 G.H5.25
Van-der-waals ICL2 I 361 - G.H5 L 358 G.H5.25
Polar TM7 S 558 7x55 G.h2s4 N 222 G.h2s4.03
Van-der-waals TM7 S 558 7x55 G.h2s4 N 222 G.h2s4.03
Hydrophobic TM5 L 464 5x42 G.H3 L 254 G.H3.08
Hydrophobic TM6 F 494 6x35 G.H5 N 357 G.H5.24
Van-der-waals TM6 F 494 6x35 G.H5 N 357 G.H5.24
Hydrophobic TM5 C 471 5x49 G.H2 I 217 G.H2.08
Aromatic TM2 F 292 2x62 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 F 292 2x62 G.hns1 R 37 G.hns1.02
Van-der-waals TM2 F 292 2x62 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 I 361 - G.S3 I 199 G.S3.01
Van-der-waals ICL2 I 361 - G.S3 I 199 G.S3.01
Hydrophobic ICL4 E 560 - G.h2s4 E 221 G.h2s4.02
Van-der-waals ICL4 E 560 - G.h2s4 E 221 G.h2s4.02
Ionic TM2 D 290 2x60 G.HN K 33 G.HN.51
Polar TM2 D 290 2x60 G.HN K 33 G.HN.51
Hydrophobic TM2 D 290 2x60 G.HN K 33 G.HN.51
Van-der-waals TM2 D 290 2x60 G.HN K 33 G.HN.51
Hydrophobic TM5 V 476 5x54 G.H3 P 262 G.H3.16
Hydrophobic TM3 H 360 3x56 G.H5 L 353 G.H5.20
Van-der-waals TM3 H 360 3x56 G.H5 L 353 G.H5.20
Polar ECL2 H 425 - G.H5 K 354 G.H5.21
Hydrophobic ECL2 H 425 - G.H5 K 354 G.H5.21
Van-der-waals ECL2 H 425 - G.H5 K 354 G.H5.21
Polar TM5 L 464 5x42 G.H3 Y 261 G.H3.15
Hydrophobic TM5 L 464 5x42 G.H3 Y 261 G.H3.15
Van-der-waals TM5 L 464 5x42 G.H3 Y 261 G.H3.15
Polar TM3 K 359 3x55 G.H5 N 357 G.H5.24
Hydrophobic TM3 K 359 3x55 G.H5 N 357 G.H5.24
Van-der-waals TM3 K 359 3x55 G.H5 N 357 G.H5.24
Polar ECL2 D 433 - G.h3s5 N 266 G.h3s5.02
Polar ECL2 T 432 - G.h4s6 D 319 G.h4s6.10
Hydrophobic ECL2 T 432 - G.h4s6 D 319 G.h4s6.10
Van-der-waals ECL2 T 432 - G.h4s6 D 319 G.h4s6.10
Hydrophobic TM7 L 557 7x54 G.h2s4 N 222 G.h2s4.03
Hydrophobic TM2 R 288 2x58 G.HN R 30 G.HN.48
Van-der-waals TM2 R 288 2x58 G.HN R 30 G.HN.48
Hydrophobic TM5 L 467 5x45 G.H2 R 213 G.H2.04
Hydrophobic TM3 I 358 3x54 G.H5 Y 356 G.H5.23
Van-der-waals TM3 I 358 3x54 G.H5 Y 356 G.H5.23
Polar ECL2 H 425 - G.H5 E 355 G.H5.22
Hydrophobic ECL2 H 425 - G.H5 E 355 G.H5.22
Van-der-waals ECL2 H 425 - G.H5 E 355 G.H5.22
Polar ICL2 D 366 - G.H5 V 359 G.H5.26
Hydrophobic ICL2 D 366 - G.H5 V 359 G.H5.26
Van-der-waals ICL2 D 366 - G.H5 V 359 G.H5.26
Hydrophobic ICL2 S 363 - G.H5 L 353 G.H5.20
Van-der-waals ICL2 S 363 - G.H5 L 353 G.H5.20
Polar TM2 N 289 2x59 G.HN E 26 G.HN.44
Hydrophobic TM2 N 289 2x59 G.HN E 26 G.HN.44
Van-der-waals TM2 N 289 2x59 G.HN E 26 G.HN.44
Polar ICL3 N 487 - G.h3s5 N 266 G.h3s5.02
Hydrophobic ICL3 N 487 - G.h3s5 N 266 G.h3s5.02
Van-der-waals ICL3 N 487 - G.h3s5 N 266 G.h3s5.02
Ionic TM2 D 290 2x60 G.hns1 R 37 G.hns1.02
Polar TM2 D 290 2x60 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 D 290 2x60 G.hns1 R 37 G.hns1.02
Van-der-waals TM2 D 290 2x60 G.hns1 R 37 G.hns1.02
Polar TM2 K 286 2x56 G.HN R 30 G.HN.48
Hydrophobic TM2 K 286 2x56 G.HN R 30 G.HN.48
Van-der-waals TM2 K 286 2x56 G.HN R 30 G.HN.48
Hydrophobic ICL2 D 366 - G.H5 L 358 G.H5.25
Van-der-waals ICL2 D 366 - G.H5 L 358 G.H5.25
Hydrophobic TM3 H 360 3x56 G.H5 L 358 G.H5.25
Hydrophobic ECL2 A 460 - G.H3 A 253 G.H3.07
Hydrophobic TM5 R 479 5x57 G.H3 W 263 G.H3.17
Van-der-waals TM5 R 479 5x57 G.H3 W 263 G.H3.17
Hydrophobic ICL2 S 363 - G.H5 Q 350 G.H5.17
Van-der-waals ICL2 S 363 - G.H5 Q 350 G.H5.17
Hydrophobic TM3 G 354 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 G 354 3x50 G.H5 Y 356 G.H5.23
Polar TM2 V 291 2x61 G.HN R 34 G.HN.52
Hydrophobic TM2 V 291 2x61 G.HN R 34 G.HN.52
Van-der-waals TM2 V 291 2x61 G.HN R 34 G.HN.52
Polar TM3 K 359 3x55 G.H5 L 353 G.H5.20
Hydrophobic TM3 K 359 3x55 G.H5 L 353 G.H5.20
Van-der-waals TM3 K 359 3x55 G.H5 L 353 G.H5.20
Hydrophobic TM3 L 350 3x46 G.H5 L 358 G.H5.25
Hydrophobic ICL2 I 361 - G.H5 L 353 G.H5.20
Van-der-waals ICL2 I 361 - G.H5 L 353 G.H5.20
Ionic TM5 D 463 5x41 G.H2 R 214 G.H2.05
Polar TM5 D 463 5x41 G.H2 R 214 G.H2.05
Van-der-waals TM5 D 463 5x41 G.H2 R 214 G.H2.05
Hydrophobic TM2 N 289 2x59 G.HN L 29 G.HN.47
Van-der-waals TM2 N 289 2x59 G.HN L 29 G.HN.47
Hydrophobic TM2 K 293 2x63 G.hns1 R 38 G.hns1.03
Van-der-waals TM2 K 293 2x63 G.hns1 R 38 G.hns1.03
Hydrophobic TM3 G 354 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 G 354 3x50 G.H5 L 358 G.H5.25
Van-der-waals ECL2 L 426 - G.H5 E 355 G.H5.22
Hydrophobic TM5 L 467 5x45 G.H2 I 217 G.H2.08
Hydrophobic TM3 K 359 3x55 G.H5 L 358 G.H5.25
Van-der-waals TM3 K 359 3x55 G.H5 L 358 G.H5.25
Polar TM3 K 359 3x55 G.H5 Y 356 G.H5.23
Hydrophobic TM3 K 359 3x55 G.H5 Y 356 G.H5.23
Van-der-waals TM3 K 359 3x55 G.H5 Y 356 G.H5.23
Polar ECL2 T 432 - G.h3s5 Q 265 G.h3s5.01
Hydrophobic TM3 T 353 3x49 G.H5 N 357 G.H5.24
Van-der-waals TM3 T 353 3x49 G.H5 N 357 G.H5.24
Polar TM3 G 354 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM3 G 354 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 G 354 3x50 G.H5 N 357 G.H5.24
Ionic TM5 R 479 5x57 G.h2s4 E 221 G.h2s4.02
Polar TM5 R 479 5x57 G.h2s4 E 221 G.h2s4.02
Polar TM3 T 353 3x49 G.H5 L 358 G.H5.25
Hydrophobic TM3 T 353 3x49 G.H5 L 358 G.H5.25
Van-der-waals TM3 T 353 3x49 G.H5 L 358 G.H5.25
Hydrophobic TM3 W 355 3x51 G.H5 L 358 G.H5.25
Van-der-waals TM3 W 355 3x51 G.H5 L 358 G.H5.25
Polar TM3 K 359 3x55 G.H5 V 359 G.H5.26
Hydrophobic TM3 K 359 3x55 G.H5 V 359 G.H5.26
Van-der-waals TM3 K 359 3x55 G.H5 V 359 G.H5.26
Polar TM7 S 550 7x47 G.HN K 33 G.HN.51
Hydrophobic TM3 I 358 3x54 G.H5 N 357 G.H5.24
Van-der-waals TM3 I 358 3x54 G.H5 N 357 G.H5.24
Polar TM7 L 555 7x52 G.hns1 R 37 G.hns1.02
Hydrophobic TM7 L 555 7x52 G.hns1 R 37 G.hns1.02
Van-der-waals TM7 L 555 7x52 G.hns1 R 37 G.hns1.02
Polar ICL2 D 364 - G.H5 Q 350 G.H5.17
Hydrophobic ICL2 D 364 - G.H5 Q 350 G.H5.17
Van-der-waals ICL2 D 364 - G.H5 Q 350 G.H5.17
Hydrophobic TM3 H 360 3x56 G.hns1 R 38 G.hns1.03
Polar TM3 H 360 3x56 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 H 360 3x56 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 H 360 3x56 G.hns1 R 37 G.hns1.02
Hydrophobic TM7 L 557 7x54 G.HN K 33 G.HN.51
Hydrophobic ECL2 W 421 - G.H5 V 359 G.H5.26
Van-der-waals ECL2 W 421 - G.H5 V 359 G.H5.26
Polar TM7 L 555 7x52 G.HN K 33 G.HN.51
Van-der-waals TM7 L 555 7x52 G.HN K 33 G.HN.51
Polar TM3 K 359 3x55 G.H5 K 354 G.H5.21
Hydrophobic TM3 K 359 3x55 G.H5 K 354 G.H5.21
Van-der-waals TM3 K 359 3x55 G.H5 K 354 G.H5.21
Hydrophobic TM3 K 359 3x55 G.H5 N 352 G.H5.19
Van-der-waals TM3 K 359 3x55 G.H5 N 352 G.H5.19
Polar TM2 R 288 2x58 G.HN R 34 G.HN.52
Hydrophobic TM2 R 288 2x58 G.HN R 34 G.HN.52
Van-der-waals TM2 R 288 2x58 G.HN R 34 G.HN.52
Polar ECL2 S 422 - G.H5 N 357 G.H5.24
Hydrophobic ECL2 S 422 - G.H5 N 357 G.H5.24
Van-der-waals ECL2 S 422 - G.H5 N 357 G.H5.24
Polar TM2 N 289 2x59 G.HN R 34 G.HN.52
Hydrophobic TM2 N 289 2x59 G.HN R 34 G.HN.52
Van-der-waals TM2 N 289 2x59 G.HN R 34 G.HN.52
Hydrophobic ICL2 S 363 - G.H5 V 359 G.H5.26
Van-der-waals ICL2 S 363 - G.H5 V 359 G.H5.26
Polar TM7 Q 559 7x56 G.HN K 33 G.HN.51
Hydrophobic TM7 Q 559 7x56 G.HN K 33 G.HN.51
Van-der-waals TM7 Q 559 7x56 G.HN K 33 G.HN.51
Hydrophobic TM5 L 467 5x45 G.H2 R 214 G.H2.05
Van-der-waals TM5 L 467 5x45 G.H2 R 214 G.H2.05
Van-der-waals ECL2 F 459 - G.s4h3 E 245 G.s4h3.14
Hydrophobic ECL2 L 426 - G.H5 N 357 G.H5.24
Van-der-waals ECL2 L 426 - G.H5 N 357 G.H5.24
Hydrophobic TM2 R 287 2x57 G.HN R 30 G.HN.48
Van-der-waals TM2 R 287 2x57 G.HN R 30 G.HN.48
Hydrophobic TM3 K 359 3x55 G.H5 E 355 G.H5.22
Polar ECL2 D 433 - G.h3s5 Q 265 G.h3s5.01
Hydrophobic ECL2 D 433 - G.h3s5 Q 265 G.h3s5.01
Van-der-waals ECL2 D 433 - G.h3s5 Q 265 G.h3s5.01
Hydrophobic ICL2 L 362 - G.H5 V 359 G.H5.26
Hydrophobic ICL4 E 560 - G.H3 W 263 G.H3.17
Van-der-waals ICL4 E 560 - G.H3 W 263 G.H3.17
Hydrophobic TM5 L 464 5x42 G.H3 T 257 G.H3.11
Hydrophobic ICL2 L 362 - G.H5 L 353 G.H5.20
Van-der-waals ICL2 L 362 - G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 362 - G.H5 L 358 G.H5.25
Hydrophobic TM3 H 360 3x56 G.S3 I 199 G.S3.01