Golf - GPR107 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 70.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 27.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term M 576 - G.h1ha F 70 G.h1ha.04
Hydrophobic TM3 I 358 3x54 G.hns1 K 40 G.hns1.02
Polar TM7 Q 556 7x53 G.HN Q 33 G.HN.48
Van-der-waals TM7 Q 556 7x53 G.HN Q 33 G.HN.48
Hydrophobic H8 E 561 8x47 G.hns1 Y 39 G.hns1.01
Van-der-waals H8 E 561 8x47 G.hns1 Y 39 G.hns1.01
Polar ICL2 S 363 - G.H5 L 375 G.H5.20
Hydrophobic ICL2 S 363 - G.H5 L 375 G.H5.20
Van-der-waals ICL2 S 363 - G.H5 L 375 G.H5.20
Van-der-waals ICL2 K 365 - G.H5 L 375 G.H5.20
Hydrophobic H8 M 566 8x52 G.H2 Q 223 G.H2.09
Hydrophobic TM7 Y 554 7x51 G.hns1 K 40 G.hns1.02
Van-der-waals TM7 Y 554 7x51 G.hns1 K 40 G.hns1.02
Hydrophobic TM7 Q 559 7x56 G.HN E 35 G.HN.50
Van-der-waals TM7 Q 559 7x56 G.HN E 35 G.HN.50
Hydrophobic TM3 I 358 3x54 G.H5 H 374 G.H5.19
Hydrophobic TM7 Q 556 7x53 G.HN R 36 G.HN.51
Van-der-waals TM7 Q 556 7x53 G.HN R 36 G.HN.51
Polar TM7 D 551 7x48 G.HN Q 33 G.HN.48
Hydrophobic TM7 D 551 7x48 G.HN Q 33 G.HN.48
Van-der-waals TM7 D 551 7x48 G.HN Q 33 G.HN.48
Polar ICL2 K 365 - G.H5 L 380 G.H5.25
Hydrophobic ICL2 K 365 - G.H5 L 380 G.H5.25
Van-der-waals ICL2 K 365 - G.H5 L 380 G.H5.25
Aromatic TM6 F 494 6x35 G.H5 H 374 G.H5.19
Hydrophobic TM6 F 494 6x35 G.H5 H 374 G.H5.19
Hydrophobic TM5 T 483 5x61 G.h2s4 D 227 G.h2s4.03
Hydrophobic ICL2 D 366 - G.H5 Y 378 G.H5.23
Van-der-waals ICL2 D 366 - G.H5 Y 378 G.H5.23
Hydrophobic ECL2 S 422 - G.H5 Y 378 G.H5.23
Van-der-waals ECL2 S 422 - G.H5 Y 378 G.H5.23
Hydrophobic ICL2 I 361 - G.H5 Q 371 G.H5.16
Van-der-waals ICL2 I 361 - G.H5 Q 371 G.H5.16
Hydrophobic TM7 L 557 7x54 G.hns1 Y 39 G.hns1.01
Van-der-waals TM7 L 557 7x54 G.hns1 Y 39 G.hns1.01
Polar TM7 D 551 7x48 G.HN K 34 G.HN.49
Hydrophobic TM2 D 290 2x60 G.HN L 37 G.HN.52
Hydrophobic TM7 A 549 7x46 G.HN L 37 G.HN.52
Van-der-waals TM7 A 549 7x46 G.HN L 37 G.HN.52
Hydrophobic C-term M 579 - H.HA E 74 H.HA.03
Van-der-waals C-term M 579 - H.HA E 74 H.HA.03
Hydrophobic C-term M 576 - H.HA E 74 H.HA.03
Van-der-waals C-term M 576 - H.HA E 74 H.HA.03
Polar ICL2 K 365 - G.H5 E 379 G.H5.24
Van-der-waals ICL2 K 365 - G.H5 E 379 G.H5.24
Polar ECL2 W 421 - G.H5 E 379 G.H5.24
Hydrophobic ECL2 W 421 - G.H5 E 379 G.H5.24
Van-der-waals ECL2 W 421 - G.H5 E 379 G.H5.24
Hydrophobic TM5 L 467 5x45 G.H2 I 222 G.H2.08
Polar ICL3 N 487 - G.h2s4 D 227 G.h2s4.03
Van-der-waals ICL3 N 487 - G.h2s4 D 227 G.h2s4.03
Hydrophobic TM3 I 358 3x54 G.H5 I 370 G.H5.15
Van-der-waals TM3 I 358 3x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 D 366 - G.H5 L 380 G.H5.25
Van-der-waals ICL2 D 366 - G.H5 L 380 G.H5.25
Polar C-term V 575 - H.HA Q 77 H.HA.06
Hydrophobic C-term V 575 - H.HA Q 77 H.HA.06
Van-der-waals C-term V 575 - H.HA Q 77 H.HA.06
Polar TM7 S 550 7x47 G.HN L 37 G.HN.52
Hydrophobic TM7 S 550 7x47 G.HN L 37 G.HN.52
Van-der-waals TM7 S 550 7x47 G.HN L 37 G.HN.52
Polar TM7 P 553 7x50 G.hns1 K 40 G.hns1.02
Van-der-waals TM7 P 553 7x50 G.hns1 K 40 G.hns1.02
Hydrophobic TM3 G 354 3x50 G.H5 H 374 G.H5.19
Polar TM3 T 353 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 T 353 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 T 353 3x49 G.H5 Y 378 G.H5.23
Polar TM3 K 359 3x55 G.H5 H 374 G.H5.19
Aromatic TM3 K 359 3x55 G.H5 H 374 G.H5.19
Hydrophobic TM3 K 359 3x55 G.H5 H 374 G.H5.19
Van-der-waals TM3 K 359 3x55 G.H5 H 374 G.H5.19
Hydrophobic TM5 L 467 5x45 G.H2 R 219 G.H2.05
Hydrophobic ICL2 K 365 - G.H5 L 381 G.H5.26
Van-der-waals ICL2 K 365 - G.H5 L 381 G.H5.26
Hydrophobic ECL2 L 426 - G.H5 Q 377 G.H5.22
Van-der-waals ECL2 L 426 - G.H5 Q 377 G.H5.22
Hydrophobic TM7 Q 559 7x56 G.HN R 36 G.HN.51
Polar TM7 Q 559 7x56 G.HN R 36 G.HN.51
Van-der-waals TM7 Q 559 7x56 G.HN R 36 G.HN.51
Hydrophobic C-term M 576 - H.HA K 78 H.HA.07
Hydrophobic ECL2 S 422 - G.H5 Q 377 G.H5.22
Van-der-waals ECL2 S 422 - G.H5 Q 377 G.H5.22
Hydrophobic ICL2 I 361 - G.H5 R 367 G.H5.12
Van-der-waals ICL2 I 361 - G.H5 R 367 G.H5.12
Ionic ECL2 H 425 - G.H5 E 379 G.H5.24
Hydrophobic ECL2 H 425 - G.H5 E 379 G.H5.24
Van-der-waals ECL2 H 425 - G.H5 E 379 G.H5.24
Hydrophobic ICL3 I 486 - G.HN R 36 G.HN.51
Van-der-waals ICL3 I 486 - G.HN R 36 G.HN.51
Polar TM6 Y 498 6x39 G.H5 Y 378 G.H5.23
Hydrophobic TM6 Y 498 6x39 G.H5 Y 378 G.H5.23
Van-der-waals TM6 Y 498 6x39 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 S 363 - G.H5 H 374 G.H5.19
Hydrophobic C-term M 576 - G.H1 R 63 G.H1.09
Van-der-waals C-term M 576 - G.H1 R 63 G.H1.09
Polar TM7 L 557 7x54 G.HN R 36 G.HN.51
Hydrophobic TM7 S 550 7x47 G.HN Q 33 G.HN.48
Van-der-waals TM7 S 550 7x47 G.HN Q 33 G.HN.48
Hydrophobic TM7 L 557 7x54 G.h2s4 D 227 G.h2s4.03
Hydrophobic TM3 T 353 3x49 G.H5 H 374 G.H5.19
Van-der-waals TM3 T 353 3x49 G.H5 H 374 G.H5.19
Polar TM3 G 352 3x48 G.H5 Y 378 G.H5.23
Hydrophobic TM3 G 352 3x48 G.H5 Y 378 G.H5.23
Van-der-waals TM3 G 352 3x48 G.H5 Y 378 G.H5.23
Polar TM3 K 359 3x55 G.H5 I 370 G.H5.15
Hydrophobic TM3 K 359 3x55 G.H5 I 370 G.H5.15
Van-der-waals TM3 K 359 3x55 G.H5 I 370 G.H5.15
Hydrophobic TM7 L 557 7x54 G.S1 T 42 G.S1.01
Van-der-waals TM7 L 557 7x54 G.S1 T 42 G.S1.01
Hydrophobic TM6 K 490 6x31 G.hns1 K 40 G.hns1.02
Van-der-waals TM6 K 490 6x31 G.hns1 K 40 G.hns1.02
Polar TM3 G 354 3x50 G.H5 Y 378 G.H5.23
Polar TM7 Q 559 7x56 G.HN L 32 G.HN.47
Hydrophobic TM7 Q 559 7x56 G.HN L 32 G.HN.47
Van-der-waals TM7 Q 559 7x56 G.HN L 32 G.HN.47
Hydrophobic TM3 K 359 3x55 G.H5 Q 371 G.H5.16
Ionic H8 E 561 8x47 G.S1 R 44 G.S1.03
Polar H8 E 561 8x47 G.S1 R 44 G.S1.03
Hydrophobic H8 E 561 8x47 G.S1 R 44 G.S1.03
Van-der-waals H8 E 561 8x47 G.S1 R 44 G.S1.03
Polar TM7 S 550 7x47 G.HN K 34 G.HN.49
Hydrophobic TM7 S 550 7x47 G.HN K 34 G.HN.49
Van-der-waals TM7 S 550 7x47 G.HN K 34 G.HN.49
Hydrophobic ICL2 I 369 - G.H5 L 380 G.H5.25
Van-der-waals ICL2 I 369 - G.H5 L 380 G.H5.25
Hydrophobic TM7 Q 556 7x53 G.HN L 37 G.HN.52
Van-der-waals TM7 Q 556 7x53 G.HN L 37 G.HN.52
Polar TM7 S 558 7x55 G.h2s4 D 227 G.h2s4.03
Hydrophobic TM7 S 558 7x55 G.h2s4 D 227 G.h2s4.03
Van-der-waals TM7 S 558 7x55 G.h2s4 D 227 G.h2s4.03
Hydrophobic TM7 N 552 7x49 G.HN L 37 G.HN.52
Hydrophobic TM7 L 557 7x54 G.hns1 K 40 G.hns1.02
Van-der-waals TM7 L 557 7x54 G.hns1 K 40 G.hns1.02
Polar TM7 L 555 7x52 G.hns1 K 40 G.hns1.02
Hydrophobic TM7 L 555 7x52 G.hns1 K 40 G.hns1.02
Van-der-waals TM7 L 555 7x52 G.hns1 K 40 G.hns1.02
Ionic ICL4 E 560 - G.HN R 36 G.HN.51
Polar ICL4 E 560 - G.HN R 36 G.HN.51
Hydrophobic ICL4 E 560 - G.HN R 36 G.HN.51
Van-der-waals ICL4 E 560 - G.HN R 36 G.HN.51
Polar TM5 T 483 5x61 G.h2s4 N 226 G.h2s4.02
Hydrophobic TM5 T 483 5x61 G.h2s4 N 226 G.h2s4.02
Van-der-waals TM5 T 483 5x61 G.h2s4 N 226 G.h2s4.02
Polar TM7 Q 559 7x56 G.hns1 Y 39 G.hns1.01
Hydrophobic TM7 Q 559 7x56 G.hns1 Y 39 G.hns1.01
Van-der-waals TM7 Q 559 7x56 G.hns1 Y 39 G.hns1.01
Hydrophobic ICL2 D 364 - G.H5 L 375 G.H5.20
Van-der-waals ICL2 D 364 - G.H5 L 375 G.H5.20
Polar TM7 Q 556 7x53 G.hns1 K 40 G.hns1.02
Hydrophobic TM7 Q 556 7x53 G.hns1 K 40 G.hns1.02
Van-der-waals TM7 Q 556 7x53 G.hns1 K 40 G.hns1.02
Hydrophobic TM7 D 551 7x48 G.HN L 37 G.HN.52
Hydrophobic TM6 F 494 6x35 G.H5 Y 378 G.H5.23
Van-der-waals TM6 F 494 6x35 G.H5 Y 378 G.H5.23
Hydrophobic TM7 L 555 7x52 G.HN L 37 G.HN.52
Van-der-waals TM7 L 555 7x52 G.HN L 37 G.HN.52
Polar TM7 S 558 7x55 G.hns1 Y 39 G.hns1.01
Hydrophobic TM7 S 558 7x55 G.hns1 Y 39 G.hns1.01
Van-der-waals TM7 S 558 7x55 G.hns1 Y 39 G.hns1.01
Hydrophobic C-term M 579 - G.H1 R 63 G.H1.09
Van-der-waals C-term M 579 - G.H1 R 63 G.H1.09