Gs - GPR107 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 70.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 28.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 H 360 3x56 G.h3s5 R 283 G.h3s5.01
Van-der-waals TM3 H 360 3x56 G.h3s5 R 283 G.h3s5.01
Polar TM7 L 557 7x54 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM7 L 557 7x54 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM7 L 557 7x54 G.h4s6 R 356 G.h4s6.12
Polar ECL2 S 422 - G.H5 Y 391 G.H5.23
Van-der-waals ECL2 S 422 - G.H5 Y 391 G.H5.23
Hydrophobic ICL4 E 560 - G.h4s6 S 352 G.h4s6.08
Hydrophobic ECL2 S 430 - G.H5 L 394 G.H5.26
Hydrophobic ECL2 L 426 - G.H5 E 392 G.H5.24
Van-der-waals ECL2 L 426 - G.H5 E 392 G.H5.24
Polar TM7 S 558 7x55 G.h4s6 S 352 G.h4s6.08
Hydrophobic TM7 S 558 7x55 G.h4s6 S 352 G.h4s6.08
Van-der-waals TM7 S 558 7x55 G.h4s6 S 352 G.h4s6.08
Hydrophobic H8 E 562 8x48 G.H3 W 277 G.H3.13
Ionic ECL2 D 433 - G.H5 R 385 G.H5.17
Polar ECL2 D 433 - G.H5 R 385 G.H5.17
Hydrophobic ECL2 D 433 - G.H5 R 385 G.H5.17
Van-der-waals ECL2 D 433 - G.H5 R 385 G.H5.17
Polar H8 E 561 8x47 G.H3 N 278 G.H3.14
Hydrophobic H8 E 561 8x47 G.H3 N 278 G.H3.14
Van-der-waals H8 E 561 8x47 G.H3 N 278 G.H3.14
Polar TM2 V 291 2x61 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM2 V 291 2x61 G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 K 365 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 365 - G.hns1 R 38 G.hns1.02
Hydrophobic ECL2 L 426 - G.H5 L 393 G.H5.25
Van-der-waals ECL2 L 426 - G.H5 L 393 G.H5.25
Hydrophobic TM6 L 491 6x32 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 491 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM7 L 557 7x54 G.h3s5 R 283 G.h3s5.01
Van-der-waals TM7 L 557 7x54 G.h3s5 R 283 G.h3s5.01
Hydrophobic ECL2 S 422 - G.H5 L 393 G.H5.25
Van-der-waals ECL2 S 422 - G.H5 L 393 G.H5.25
Polar TM7 Q 559 7x56 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM7 Q 559 7x56 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM7 Q 559 7x56 G.h4s6 D 354 G.h4s6.10
Polar TM7 S 558 7x55 G.h4s6 H 357 G.h4s6.13
Hydrophobic TM7 S 558 7x55 G.h4s6 H 357 G.h4s6.13
Van-der-waals TM7 S 558 7x55 G.h4s6 H 357 G.h4s6.13
Polar TM7 S 558 7x55 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM7 S 558 7x55 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM7 S 558 7x55 G.h4s6 D 354 G.h4s6.10
Polar TM3 H 360 3x56 G.h3s5 T 284 G.h3s5.02
Hydrophobic TM3 H 360 3x56 G.h3s5 T 284 G.h3s5.02
Van-der-waals TM3 H 360 3x56 G.h3s5 T 284 G.h3s5.02
Polar TM3 I 358 3x54 G.h3s5 T 284 G.h3s5.02
Hydrophobic TM3 I 358 3x54 G.h3s5 T 284 G.h3s5.02
Van-der-waals TM3 I 358 3x54 G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL3 A 484 - G.H5 R 385 G.H5.17
Ionic TM5 R 479 5x57 G.hgh4 D 323 G.hgh4.13
Polar TM5 R 479 5x57 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 R 479 5x57 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 R 479 5x57 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 I 361 - G.h2s4 F 238 G.h2s4.01
Hydrophobic ECL2 H 425 - G.H5 L 388 G.H5.20
Van-der-waals ECL2 H 425 - G.H5 L 388 G.H5.20
Hydrophobic TM3 F 357 3x53 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM3 F 357 3x53 G.h4s6 R 356 G.h4s6.12
Polar ICL4 E 560 - G.h4s6 A 351 G.h4s6.04
Hydrophobic ICL4 E 560 - G.h4s6 A 351 G.h4s6.04
Van-der-waals ICL4 E 560 - G.h4s6 A 351 G.h4s6.04
Polar TM2 D 290 2x60 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM2 D 290 2x60 G.h4s6 R 356 G.h4s6.12
Polar TM3 G 354 3x50 G.H5 E 392 G.H5.24
Van-der-waals TM3 G 354 3x50 G.H5 E 392 G.H5.24
Hydrophobic TM3 H 360 3x56 G.H3 W 281 G.H3.17
Van-der-waals TM3 H 360 3x56 G.H3 W 281 G.H3.17
Ionic H8 E 561 8x47 G.H3 K 274 G.H3.10
Polar H8 E 561 8x47 G.H3 K 274 G.H3.10
Hydrophobic H8 E 561 8x47 G.H3 K 274 G.H3.10
Van-der-waals H8 E 561 8x47 G.H3 K 274 G.H3.10
Hydrophobic ICL2 I 361 - G.h2s4 N 239 G.h2s4.02
Van-der-waals ICL2 I 361 - G.h2s4 N 239 G.h2s4.02
Polar H8 E 561 8x47 G.h4s6 A 351 G.h4s6.04
Hydrophobic H8 E 561 8x47 G.h4s6 A 351 G.h4s6.04
Polar H8 E 561 8x47 G.h4s6 I 348 G.h4s6.01
Hydrophobic H8 E 561 8x47 G.h4s6 I 348 G.h4s6.01
Van-der-waals H8 E 561 8x47 G.h4s6 I 348 G.h4s6.01
Hydrophobic TM7 Q 556 7x53 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM7 Q 556 7x53 G.h4s6 G 355 G.h4s6.11
Polar TM7 Q 559 7x56 G.h4s6 S 352 G.h4s6.08
Hydrophobic TM7 Q 559 7x56 G.h4s6 S 352 G.h4s6.08
Van-der-waals TM7 Q 559 7x56 G.h4s6 S 352 G.h4s6.08
Polar TM6 K 490 6x31 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 K 490 6x31 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM3 F 357 3x53 G.h3s5 T 284 G.h3s5.02
Van-der-waals TM3 F 357 3x53 G.h3s5 T 284 G.h3s5.02
Hydrophobic TM7 S 558 7x55 G.h4s6 G 353 G.h4s6.09
Van-der-waals TM7 S 558 7x55 G.h4s6 G 353 G.h4s6.09
Polar TM7 Q 556 7x53 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ECL2 A 429 - G.H5 L 388 G.H5.20
Van-der-waals ECL2 A 429 - G.H5 L 388 G.H5.20
Hydrophobic ECL2 S 422 - G.H5 E 392 G.H5.24
Polar TM7 S 558 7x55 G.H3 W 277 G.H3.13
Hydrophobic TM7 S 558 7x55 G.H3 W 277 G.H3.13
Van-der-waals TM7 S 558 7x55 G.H3 W 277 G.H3.13
Hydrophobic ICL2 S 363 - G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 358 3x54 G.H5 Q 390 G.H5.22
Polar TM6 K 490 6x31 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 K 490 6x31 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM6 K 490 6x31 G.h4s6 R 356 G.h4s6.12
Hydrophobic H8 M 566 8x52 G.H3 N 279 G.H3.15
Van-der-waals ICL3 N 487 - G.H5 L 394 G.H5.26
Polar TM7 Q 556 7x53 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM7 Q 556 7x53 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM7 Q 556 7x53 G.h4s6 R 356 G.h4s6.12
Ionic H8 E 562 8x48 G.h4s6 H 357 G.h4s6.13
Polar H8 E 562 8x48 G.h4s6 H 357 G.h4s6.13
Polar ICL2 D 364 - G.h2s4 D 240 G.h2s4.03
Van-der-waals ICL2 D 364 - G.h2s4 D 240 G.h2s4.03
Hydrophobic TM3 G 352 3x48 G.H5 E 392 G.H5.24
Van-der-waals TM3 G 352 3x48 G.H5 E 392 G.H5.24
Hydrophobic H8 M 566 8x52 G.H3 N 278 G.H3.14
Van-der-waals H8 M 566 8x52 G.H3 N 278 G.H3.14
Hydrophobic ICL2 I 361 - G.H3 W 281 G.H3.17
Hydrophobic TM3 I 358 3x54 G.H5 R 389 G.H5.21
Polar TM3 K 359 3x55 G.H5 Q 390 G.H5.22
Hydrophobic TM3 K 359 3x55 G.H5 Q 390 G.H5.22
Van-der-waals TM3 K 359 3x55 G.H5 Q 390 G.H5.22
Polar TM6 L 491 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 491 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 491 6x32 G.H5 L 394 G.H5.26
Polar TM7 L 557 7x54 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM7 L 557 7x54 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM7 L 557 7x54 G.h4s6 D 354 G.h4s6.10
Polar TM6 Y 498 6x39 G.H5 E 392 G.H5.24
Hydrophobic TM6 Y 498 6x39 G.H5 E 392 G.H5.24
Van-der-waals TM6 Y 498 6x39 G.H5 E 392 G.H5.24
Hydrophobic ECL2 W 421 - G.HN Q 35 G.HN.52
Van-der-waals ECL2 W 421 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 K 365 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 K 365 - G.HN Q 35 G.HN.52
Polar TM7 Q 556 7x53 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM7 Q 556 7x53 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM7 Q 556 7x53 G.h4s6 D 354 G.h4s6.10
Aromatic TM2 F 292 2x62 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM2 F 292 2x62 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM2 F 292 2x62 G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 K 368 - G.HN K 34 G.HN.51
Polar ICL2 K 367 - G.h2s4 N 239 G.h2s4.02
Van-der-waals ICL2 K 367 - G.h2s4 N 239 G.h2s4.02
Ionic ICL2 D 366 - G.hns1 R 38 G.hns1.02
Polar ICL2 D 366 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 D 366 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 F 494 6x35 G.H5 E 392 G.H5.24
Van-der-waals TM6 F 494 6x35 G.H5 E 392 G.H5.24
Ionic H8 E 565 8x51 G.H3 K 274 G.H3.10
Polar H8 E 565 8x51 G.H3 K 274 G.H3.10
Hydrophobic H8 E 565 8x51 G.H3 K 274 G.H3.10
Van-der-waals H8 E 565 8x51 G.H3 K 274 G.H3.10
Polar ICL3 N 487 - G.H5 R 389 G.H5.21
Hydrophobic ICL3 N 487 - G.H5 R 389 G.H5.21
Van-der-waals ICL3 N 487 - G.H5 R 389 G.H5.21
Hydrophobic ICL2 S 363 - G.h2s4 D 240 G.h2s4.03
Van-der-waals ICL2 S 363 - G.h2s4 D 240 G.h2s4.03
Hydrophobic ECL2 A 429 - G.H5 L 394 G.H5.26
Hydrophobic TM6 K 490 6x31 G.H5 R 389 G.H5.21
Van-der-waals TM6 K 490 6x31 G.H5 R 389 G.H5.21
Ionic H8 E 562 8x48 G.h3s5 R 283 G.h3s5.01
Polar H8 E 562 8x48 G.h3s5 R 283 G.h3s5.01
Hydrophobic H8 E 562 8x48 G.h3s5 R 283 G.h3s5.01
Van-der-waals H8 E 562 8x48 G.h3s5 R 283 G.h3s5.01
Polar ECL2 S 422 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 I 486 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 I 486 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ECL2 H 425 - G.H5 L 393 G.H5.25
Van-der-waals ECL2 H 425 - G.H5 L 393 G.H5.25
Polar ICL2 D 364 - G.h2s4 N 239 G.h2s4.02
Van-der-waals ICL2 D 364 - G.h2s4 N 239 G.h2s4.02
Polar TM7 L 557 7x54 G.h4s6 H 357 G.h4s6.13
Hydrophobic TM7 L 557 7x54 G.h4s6 H 357 G.h4s6.13
Van-der-waals TM7 L 557 7x54 G.h4s6 H 357 G.h4s6.13
Polar TM3 T 353 3x49 G.H5 E 392 G.H5.24
Hydrophobic TM3 T 353 3x49 G.H5 E 392 G.H5.24
Van-der-waals TM3 T 353 3x49 G.H5 E 392 G.H5.24
Polar ICL3 I 486 - G.H5 R 389 G.H5.21
Van-der-waals ICL3 I 486 - G.H5 R 389 G.H5.21
Polar ICL2 K 365 - G.HN K 34 G.HN.51
Hydrophobic ICL2 K 365 - G.HN K 34 G.HN.51
Van-der-waals ICL2 K 365 - G.HN K 34 G.HN.51
Polar TM3 K 359 3x55 G.h3s5 T 284 G.h3s5.02
Hydrophobic TM3 K 359 3x55 G.h3s5 T 284 G.h3s5.02
Van-der-waals TM3 K 359 3x55 G.h3s5 T 284 G.h3s5.02
Polar TM7 L 557 7x54 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM7 L 557 7x54 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM7 L 557 7x54 G.h4s6 G 355 G.h4s6.11
Polar TM7 Q 559 7x56 G.h4s6 A 351 G.h4s6.04
Ionic H8 D 563 8x49 G.h3s5 R 283 G.h3s5.01
Polar H8 D 563 8x49 G.h3s5 R 283 G.h3s5.01
Van-der-waals H8 D 563 8x49 G.h3s5 R 283 G.h3s5.01
Ionic TM3 K 359 3x55 G.h2s4 D 240 G.h2s4.03
Polar TM3 K 359 3x55 G.h2s4 D 240 G.h2s4.03
Van-der-waals TM3 K 359 3x55 G.h2s4 D 240 G.h2s4.03
Van-der-waals TM7 Q 559 7x56 G.h4s6 G 353 G.h4s6.09
Polar TM3 K 359 3x55 G.H5 Y 391 G.H5.23
Aromatic TM3 K 359 3x55 G.H5 Y 391 G.H5.23
Hydrophobic TM3 K 359 3x55 G.H5 Y 391 G.H5.23
Van-der-waals TM3 K 359 3x55 G.H5 Y 391 G.H5.23
Hydrophobic H8 E 561 8x47 G.h4s6 S 352 G.h4s6.08
Van-der-waals H8 E 561 8x47 G.h4s6 S 352 G.h4s6.08
Polar H8 E 562 8x48 G.h4s6 S 352 G.h4s6.08
Hydrophobic H8 E 562 8x48 G.h4s6 S 352 G.h4s6.08
Van-der-waals H8 E 562 8x48 G.h4s6 S 352 G.h4s6.08
Polar H8 E 562 8x48 G.H3 N 278 G.H3.14
Hydrophobic H8 E 562 8x48 G.H3 N 278 G.H3.14
Van-der-waals H8 E 562 8x48 G.H3 N 278 G.H3.14
Polar TM3 H 360 3x56 G.H3 R 280 G.H3.16
Hydrophobic TM3 H 360 3x56 G.H3 R 280 G.H3.16
Van-der-waals TM3 H 360 3x56 G.H3 R 280 G.H3.16
Hydrophobic ICL3 N 487 - G.H5 R 385 G.H5.17
Hydrophobic TM5 T 483 5x61 G.S6 Y 360 G.S6.02