Gi3 - GPR157 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 A 223 6x42 G.H5 Y 354 G.H5.26
Hydrophobic TM6 A 223 6x42 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 223 6x42 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 217 6x36 G.H5 D 341 G.H5.13
Van-der-waals TM6 L 217 6x36 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 115 - G.HN E 28 G.HN.52
Van-der-waals ICL2 P 115 - G.HN E 28 G.HN.52
Hydrophobic TM3 I 108 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 108 3x54 G.H5 I 344 G.H5.16
Polar ICL1 S 44 - G.H5 C 351 G.H5.23
Hydrophobic ICL1 S 44 - G.H5 C 351 G.H5.23
Van-der-waals ICL1 S 44 - G.H5 C 351 G.H5.23
Polar ICL2 P 115 - G.HN R 24 G.HN.48
Hydrophobic ICL2 P 115 - G.HN R 24 G.HN.48
Van-der-waals ICL2 P 115 - G.HN R 24 G.HN.48
Hydrophobic TM3 I 108 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM6 K 226 6x45 G.H5 Y 354 G.H5.26
Hydrophobic TM2 A 46 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 A 46 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 G 114 - G.HN E 28 G.HN.52
Hydrophobic ICL4 T 283 - G.H5 Y 354 G.H5.26
Van-der-waals ICL4 T 283 - G.H5 Y 354 G.H5.26
Hydrophobic TM3 L 104 3x50 G.H5 L 348 G.H5.20
Hydrophobic TM7 F 279 7x53 G.H5 L 353 G.H5.25
Van-der-waals TM7 F 279 7x53 G.H5 L 353 G.H5.25
Polar ICL1 S 44 - G.H5 E 350 G.H5.22
Hydrophobic ICL1 S 44 - G.H5 E 350 G.H5.22
Van-der-waals ICL1 S 44 - G.H5 E 350 G.H5.22
Polar ICL4 T 283 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 T 283 - G.H5 G 352 G.H5.24
Hydrophobic C-term L 332 - G.H2 K 209 G.H2.05
Polar TM6 K 226 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 226 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 226 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 104 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 104 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 113 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 113 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 113 - G.hns1 A 31 G.hns1.02
Ionic TM6 H 219 6x38 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 219 6x38 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 217 6x36 G.H5 I 344 G.H5.16
Van-der-waals TM6 L 217 6x36 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 227 6x46 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 104 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 104 3x50 G.H5 L 353 G.H5.25
Polar TM3 S 107 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM2 R 47 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 47 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM6 I 230 6x49 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 230 6x49 G.H5 L 353 G.H5.25
Hydrophobic ICL2 G 114 - G.hns1 A 31 G.hns1.02
Polar TM2 R 47 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 47 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 47 2x40 G.H5 C 351 G.H5.23
Polar TM6 K 226 6x45 G.H5 G 352 G.H5.24
Polar ICL2 R 113 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 R 113 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 113 - G.H5 I 343 G.H5.15
Ionic ICL4 R 284 - G.h4s6 D 315 G.h4s6.09
Polar ICL4 R 284 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL4 R 284 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL4 R 284 - G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 Y 103 3x49 G.H5 C 351 G.H5.23
Polar ICL2 R 113 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 113 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 113 - G.H5 N 347 G.H5.19
Hydrophobic TM7 F 279 7x53 G.H5 G 352 G.H5.24