Gs - GPR157 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 80.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 F 279 7x53 G.H5 L 394 G.H5.26
Van-der-waals TM7 F 279 7x53 G.H5 L 394 G.H5.26
Hydrophobic ICL1 D 41 - G.HN K 34 G.HN.51
Hydrophobic TM2 A 46 2x39 G.H5 L 393 G.H5.25
Van-der-waals TM2 A 46 2x39 G.H5 L 393 G.H5.25
Hydrophobic ICL1 R 43 - G.H5 L 393 G.H5.25
Van-der-waals ICL1 R 43 - G.H5 L 393 G.H5.25
Hydrophobic TM3 S 107 3x53 G.H5 L 388 G.H5.20
Hydrophobic ICL2 R 113 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 113 - G.S3 V 217 G.S3.01
Polar ICL1 D 41 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 D 41 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 D 41 - G.hns1 R 38 G.hns1.02
Polar ICL4 R 284 - G.H5 E 392 G.H5.24
Hydrophobic ICL4 R 284 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 R 284 - G.H5 E 392 G.H5.24
Polar ICL1 S 44 - G.H5 L 393 G.H5.25
Hydrophobic ICL1 S 44 - G.H5 L 393 G.H5.25
Van-der-waals ICL1 S 44 - G.H5 L 393 G.H5.25
Hydrophobic TM3 I 100 3x46 G.H5 L 394 G.H5.26
Hydrophobic TM2 A 46 2x39 G.H5 L 394 G.H5.26
Polar TM3 S 107 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM3 S 107 3x53 G.H5 Q 384 G.H5.16
Van-der-waals TM3 S 107 3x53 G.H5 Q 384 G.H5.16
Polar ICL2 R 113 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 113 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 113 - G.S1 H 41 G.S1.02
Hydrophobic TM6 S 221 6x40 G.H5 R 389 G.H5.21
Van-der-waals TM6 S 221 6x40 G.H5 R 389 G.H5.21
Polar ICL4 A 285 - G.H5 E 392 G.H5.24
Hydrophobic ICL4 A 285 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 A 285 - G.H5 E 392 G.H5.24
Polar ICL1 P 40 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 P 40 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 P 40 - G.hns1 R 38 G.hns1.02
Polar TM6 H 214 6x33 G.H5 R 385 G.H5.17
Aromatic TM6 H 214 6x33 G.H5 R 385 G.H5.17
Hydrophobic TM6 H 214 6x33 G.H5 R 385 G.H5.17
Van-der-waals TM6 H 214 6x33 G.H5 R 385 G.H5.17
Polar TM3 I 108 3x54 G.H5 R 385 G.H5.17
Hydrophobic TM3 I 108 3x54 G.H5 R 385 G.H5.17
Hydrophobic ICL1 L 42 - G.H5 L 393 G.H5.25
Van-der-waals ICL1 L 42 - G.H5 L 393 G.H5.25
Aromatic ICL2 R 113 - G.H5 H 387 G.H5.19
Hydrophobic TM3 L 104 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 L 104 3x50 G.H5 L 394 G.H5.26
Polar ICL2 R 113 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 113 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 R 113 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 111 - G.H5 D 381 G.H5.13
Van-der-waals ICL2 A 111 - G.H5 D 381 G.H5.13
Polar TM6 K 226 6x45 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 226 6x45 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 226 6x45 G.H5 L 394 G.H5.26
Polar TM2 R 47 2x40 G.H5 L 393 G.H5.25
Hydrophobic TM2 R 47 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM2 R 47 2x40 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 115 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 P 115 - G.s2s3 K 216 G.s2s3.02
Aromatic TM6 H 219 6x38 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 H 219 6x38 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 H 219 6x38 G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL2 R 113 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 A 111 - G.H5 Q 384 G.H5.16
Polar ICL2 G 114 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 G 114 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 G 114 - G.s2s3 D 215 G.s2s3.01
Polar ICL1 R 43 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 43 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 L 217 6x36 G.S6 Y 360 G.S6.02
Hydrophobic ICL4 T 283 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 T 283 - G.H5 E 392 G.H5.24
Polar TM2 R 47 2x40 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 108 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 108 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 G 114 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 A 111 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 111 - G.H5 R 380 G.H5.12
Polar TM2 R 47 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM2 R 47 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 R 47 2x40 G.H5 E 392 G.H5.24