Gt1 - GPR157 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 18.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 111 - G.H5 I 340 G.H5.16
Hydrophobic TM3 I 108 3x54 G.H5 I 340 G.H5.16
Ionic ICL1 R 45 - G.HN E 24 G.HN.52
Van-der-waals ICL1 R 45 - G.HN E 24 G.HN.52
Polar ICL1 S 44 - G.H5 C 347 G.H5.23
Hydrophobic ICL1 S 44 - G.H5 C 347 G.H5.23
Van-der-waals ICL1 S 44 - G.H5 C 347 G.H5.23
Hydrophobic ICL2 P 115 - G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 P 115 - G.hns1 R 28 G.hns1.03
Hydrophobic TM6 I 230 6x49 G.H5 L 349 G.H5.25
Hydrophobic TM3 I 108 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 I 108 3x54 G.H5 L 344 G.H5.20
Hydrophobic ICL2 A 111 - G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 A 111 - G.s2s3 D 189 G.s2s3.02
Hydrophobic TM2 A 46 2x39 G.H5 C 347 G.H5.23
Polar TM6 K 226 6x45 G.H5 G 348 G.H5.24
Van-der-waals TM6 K 226 6x45 G.H5 G 348 G.H5.24
Polar ICL4 T 283 - G.H5 G 348 G.H5.24
Hydrophobic ICL4 T 283 - G.H5 G 348 G.H5.24
Van-der-waals ICL4 T 283 - G.H5 G 348 G.H5.24
Ionic TM6 D 224 6x43 G.H5 K 341 G.H5.17
Hydrophobic TM6 D 224 6x43 G.H5 K 341 G.H5.17
Van-der-waals TM6 D 224 6x43 G.H5 K 341 G.H5.17
Polar ICL2 G 114 - G.s2s3 D 189 G.s2s3.02
Hydrophobic ICL2 G 114 - G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 G 114 - G.s2s3 D 189 G.s2s3.02
Hydrophobic ICL4 R 284 - G.h4s6 V 312 G.h4s6.10
Hydrophobic ICL2 R 113 - G.S3 L 190 G.S3.01
Van-der-waals ICL2 R 113 - G.S3 L 190 G.S3.01
Hydrophobic TM6 M 222 6x41 G.H5 F 350 G.H5.26
Van-der-waals TM6 M 222 6x41 G.H5 F 350 G.H5.26
Hydrophobic TM6 A 223 6x42 G.H5 L 349 G.H5.25
Van-der-waals TM6 A 223 6x42 G.H5 L 349 G.H5.25
Polar ICL2 G 114 - G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 G 114 - G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 G 114 - G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 D 118 - G.HN E 24 G.HN.52
Van-der-waals ICL2 D 118 - G.HN E 24 G.HN.52
Hydrophobic TM3 L 104 3x50 G.H5 L 344 G.H5.20
Aromatic TM6 H 219 6x38 G.S6 Y 316 G.S6.02
Hydrophobic TM6 H 219 6x38 G.S6 Y 316 G.S6.02
Van-der-waals TM6 H 219 6x38 G.S6 Y 316 G.S6.02
Hydrophobic TM6 A 223 6x42 G.H5 F 350 G.H5.26
Van-der-waals TM6 A 223 6x42 G.H5 F 350 G.H5.26
Hydrophobic ICL2 A 111 - G.s2s3 K 188 G.s2s3.01
Hydrophobic TM3 I 100 3x46 G.H5 L 349 G.H5.25
Van-der-waals TM3 I 100 3x46 G.H5 L 349 G.H5.25
Ionic ICL2 D 118 - G.hns1 R 28 G.hns1.03
Polar ICL2 D 118 - G.hns1 R 28 G.hns1.03
Polar ICL2 R 113 - G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 R 113 - G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 R 113 - G.hns1 R 28 G.hns1.03
Ionic TM6 H 219 6x38 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 H 219 6x38 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 H 219 6x38 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM7 F 279 7x53 G.H5 G 348 G.H5.24
Van-der-waals TM7 F 279 7x53 G.H5 G 348 G.H5.24
Hydrophobic ICL2 A 112 - G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 A 112 - G.s2s3 D 189 G.s2s3.02
Hydrophobic TM2 A 46 2x39 G.H5 L 349 G.H5.25
Van-der-waals TM2 A 46 2x39 G.H5 L 349 G.H5.25
Hydrophobic TM3 L 104 3x50 G.H5 L 349 G.H5.25
Polar TM2 R 47 2x40 G.H5 C 347 G.H5.23
Hydrophobic TM2 R 47 2x40 G.H5 C 347 G.H5.23
Van-der-waals TM2 R 47 2x40 G.H5 C 347 G.H5.23
Ionic ICL4 R 284 - G.h4s6 D 311 G.h4s6.09
Polar ICL4 R 284 - G.h4s6 D 311 G.h4s6.09
Polar TM6 H 219 6x38 G.H5 K 341 G.H5.17
Hydrophobic TM6 H 219 6x38 G.H5 K 341 G.H5.17
Van-der-waals TM6 H 219 6x38 G.H5 K 341 G.H5.17
Hydrophobic TM2 R 47 2x40 G.H5 G 348 G.H5.24
Polar TM6 K 226 6x45 G.H5 F 350 G.H5.26
Hydrophobic TM6 K 226 6x45 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 226 6x45 G.H5 F 350 G.H5.26
Polar TM2 R 47 2x40 G.H5 D 346 G.H5.22
Hydrophobic ICL2 R 113 - G.H5 N 343 G.H5.19
Hydrophobic TM6 S 221 6x40 G.H5 K 345 G.H5.21
Polar ICL2 T 117 - G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 T 117 - G.hns1 R 28 G.hns1.03
Polar ICL2 R 113 - G.H5 I 340 G.H5.16
Hydrophobic ICL2 R 113 - G.H5 I 340 G.H5.16
Hydrophobic TM3 I 108 3x54 G.H5 F 350 G.H5.26
Hydrophobic TM6 K 226 6x45 G.H5 L 349 G.H5.25
Van-der-waals TM6 K 226 6x45 G.H5 L 349 G.H5.25
Hydrophobic TM6 L 227 6x46 G.H5 F 350 G.H5.26
Hydrophobic TM7 F 279 7x53 G.H5 L 349 G.H5.25
Van-der-waals TM7 F 279 7x53 G.H5 L 349 G.H5.25
Polar TM6 S 221 6x40 G.H5 K 341 G.H5.17
Hydrophobic TM6 S 221 6x40 G.H5 K 341 G.H5.17
Van-der-waals TM6 S 221 6x40 G.H5 K 341 G.H5.17
Polar ICL2 R 113 - G.s2s3 D 189 G.s2s3.02
Hydrophobic ICL2 R 113 - G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 R 113 - G.s2s3 D 189 G.s2s3.02
Hydrophobic TM6 S 221 6x40 G.H5 F 350 G.H5.26
Van-der-waals TM6 S 221 6x40 G.H5 F 350 G.H5.26
Hydrophobic TM6 L 217 6x36 G.H5 D 337 G.H5.13
Van-der-waals TM6 L 217 6x36 G.H5 D 337 G.H5.13