G13 - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 E 313 6x29 G.H5 L 376 G.H5.25
Hydrophobic TM6 F 314 6x30 G.H5 M 375 G.H5.24
Van-der-waals TM6 F 314 6x30 G.H5 M 375 G.H5.24
Hydrophobic ICL2 K 126 34x51 G.HN K 42 G.HN.51
Van-der-waals ICL2 K 126 34x51 G.HN K 42 G.HN.51
Ionic TM6 D 309 6x25 G.H5 K 372 G.H5.21
Polar TM6 D 309 6x25 G.H5 K 372 G.H5.21
Hydrophobic TM6 D 309 6x25 G.H5 K 372 G.H5.21
Van-der-waals TM6 D 309 6x25 G.H5 K 372 G.H5.21
Van-der-waals ICL3 A 307 - G.h4s6 Q 338 G.h4s6.12
Polar TM5 Q 219 5x35 G.H5 R 360 G.H5.09
Hydrophobic TM5 Q 219 5x35 G.H5 R 360 G.H5.09
Van-der-waals TM5 Q 219 5x35 G.H5 R 360 G.H5.09
Polar ICL2 K 126 34x51 G.HN Y 44 G.HN.53
Aromatic ICL2 K 126 34x51 G.HN Y 44 G.HN.53
Hydrophobic ICL2 K 126 34x51 G.HN Y 44 G.HN.53
Van-der-waals ICL2 K 126 34x51 G.HN Y 44 G.HN.53
Hydrophobic ICL2 Q 130 34x55 G.HN S 39 G.HN.48
Van-der-waals ICL2 Q 130 34x55 G.HN S 39 G.HN.48
Hydrophobic TM2 F 55 2x39 G.H5 Q 377 G.H5.26
Van-der-waals TM2 F 55 2x39 G.H5 Q 377 G.H5.26
Polar ECL2 A 211 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ECL2 A 211 - G.s2s3 K 214 G.s2s3.01
Polar TM5 Y 215 5x31 G.H5 R 360 G.H5.09
Aromatic TM5 Y 215 5x31 G.H5 R 360 G.H5.09
Hydrophobic TM5 Y 215 5x31 G.H5 R 360 G.H5.09
Van-der-waals TM5 Y 215 5x31 G.H5 R 360 G.H5.09
Hydrophobic TM3 L 121 3x53 G.H5 Q 377 G.H5.26
Hydrophobic TM5 I 222 5x38 G.H5 R 360 G.H5.09
Van-der-waals TM5 I 222 5x38 G.H5 R 360 G.H5.09
Hydrophobic TM2 T 53 2x37 G.H5 Q 377 G.H5.26
Van-der-waals TM2 T 53 2x37 G.H5 Q 377 G.H5.26
Polar ICL2 P 125 34x50 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 P 125 34x50 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 P 125 34x50 G.hns1 K 46 G.hns1.02
Van-der-waals TM6 P 308 6x24 G.h4s6 Q 338 G.h4s6.12
Polar ICL2 Q 130 34x55 G.HN L 38 G.HN.47
Hydrophobic ICL2 Q 130 34x55 G.HN L 38 G.HN.47
Van-der-waals ICL2 Q 130 34x55 G.HN L 38 G.HN.47
Polar TM3 R 118 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 R 118 3x50 G.H5 M 375 G.H5.24
Polar TM3 R 118 3x50 G.H5 Q 377 G.H5.26
Van-der-waals TM3 R 118 3x50 G.H5 Q 377 G.H5.26
Hydrophobic ECL2 L 212 - G.H5 D 364 G.H5.13
Van-der-waals ECL2 L 212 - G.H5 D 364 G.H5.13
Hydrophobic TM6 S 311 6x27 G.H5 L 376 G.H5.25
Polar ICL2 L 127 34x52 G.HN K 42 G.HN.51
Hydrophobic ICL2 L 127 34x52 G.HN K 42 G.HN.51
Van-der-waals ICL2 L 127 34x52 G.HN K 42 G.HN.51
Hydrophobic ICL2 F 128 34x53 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 F 128 34x53 G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 A 208 - G.H5 L 371 G.H5.20
Van-der-waals ECL2 A 208 - G.H5 L 371 G.H5.20
Hydrophobic TM6 G 315 6x31 G.H5 M 375 G.H5.24
Van-der-waals TM6 G 315 6x31 G.H5 M 375 G.H5.24
Hydrophobic ICL2 L 127 34x52 G.HN S 39 G.HN.48
Hydrophobic TM3 I 122 3x54 G.H5 M 375 G.H5.24
Polar ICL2 K 126 34x51 G.HN R 40 G.HN.49
Hydrophobic ICL2 K 126 34x51 G.HN R 40 G.HN.49
Van-der-waals ICL2 K 126 34x51 G.HN R 40 G.HN.49
Hydrophobic TM3 L 121 3x53 G.hns1 K 46 G.hns1.02
Polar TM5 Y 215 5x31 G.H5 R 356 G.H5.05
Van-der-waals TM5 Y 215 5x31 G.H5 R 356 G.H5.05
Hydrophobic TM3 H 124 3x56 G.HN T 43 G.HN.52
Van-der-waals TM3 H 124 3x56 G.HN T 43 G.HN.52
Hydrophobic TM5 R 218 5x34 G.H5 R 360 G.H5.09
Hydrophobic ICL2 L 127 34x52 G.HN T 43 G.HN.52
Van-der-waals ICL2 L 127 34x52 G.HN T 43 G.HN.52
Hydrophobic TM6 S 310 6x26 G.H5 L 376 G.H5.25
Hydrophobic TM3 L 121 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 L 374 G.H5.23
Hydrophobic TM3 I 122 3x54 G.H5 L 371 G.H5.20
Hydrophobic ICL3 A 307 - G.h4s6 P 341 G.h4s6.20
Hydrophobic ICL2 Q 130 34x55 G.HN K 42 G.HN.51
Van-der-waals ICL2 Q 130 34x55 G.HN K 42 G.HN.51
Hydrophobic ICL2 P 125 34x50 G.H5 L 374 G.H5.23
Aromatic TM3 H 124 3x56 G.hns1 R 47 G.hns1.03
Hydrophobic TM6 F 314 6x30 G.H5 L 374 G.H5.23
Van-der-waals TM6 F 314 6x30 G.H5 L 374 G.H5.23
Polar TM6 S 311 6x27 G.H5 K 372 G.H5.21
Hydrophobic TM6 S 311 6x27 G.H5 K 372 G.H5.21
Van-der-waals TM6 S 311 6x27 G.H5 K 372 G.H5.21
Hydrophobic ICL2 K 126 34x51 G.HN E 41 G.HN.50
Van-der-waals ICL2 K 126 34x51 G.HN E 41 G.HN.50
Hydrophobic TM6 F 314 6x30 G.H5 Q 377 G.H5.26
Van-der-waals TM6 F 314 6x30 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 P 125 34x50 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 P 125 34x50 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 P 129 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 P 129 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 K 126 34x51 G.hns1 V 45 G.hns1.01
Van-der-waals ICL2 K 126 34x51 G.hns1 V 45 G.hns1.01
Polar ICL2 P 125 34x50 G.HN T 43 G.HN.52
Van-der-waals ICL2 P 125 34x50 G.HN T 43 G.HN.52
Polar TM5 Y 215 5x31 G.H5 L 357 G.H5.06
Hydrophobic TM5 Y 215 5x31 G.H5 L 357 G.H5.06
Polar ICL2 K 126 34x51 G.HN T 43 G.HN.52
Hydrophobic ICL2 K 126 34x51 G.HN T 43 G.HN.52
Van-der-waals ICL2 K 126 34x51 G.HN T 43 G.HN.52
Polar TM3 A 123 3x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 A 123 3x55 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 A 123 3x55 G.hns1 R 47 G.hns1.03
Polar TM6 T 318 6x34 G.H5 M 375 G.H5.24
Hydrophobic TM6 F 314 6x30 G.H5 L 376 G.H5.25
Van-der-waals TM6 F 314 6x30 G.H5 L 376 G.H5.25
Polar TM5 Q 219 5x35 G.H5 D 361 G.H5.10
Hydrophobic TM5 Q 219 5x35 G.H5 D 361 G.H5.10
Van-der-waals TM5 Q 219 5x35 G.H5 D 361 G.H5.10