G15 - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 H 223 5x39 G.H4 R 310 G.H4.09
Hydrophobic TM5 H 223 5x39 G.H4 R 310 G.H4.09
Van-der-waals TM5 H 223 5x39 G.H4 R 310 G.H4.09
Polar TM5 P 235 5x50 G.HG E 283 G.HG.05
Hydrophobic TM5 P 235 5x50 G.HG E 283 G.HG.05
Van-der-waals TM5 P 235 5x50 G.HG E 283 G.HG.05
Hydrophobic TM5 L 241 5x56 H.HA N 85 H.HA.14
Van-der-waals TM5 L 241 5x56 H.HA N 85 H.HA.14
Hydrophobic TM5 L 245 5x60 H.hbhc K 123 H.hbhc.02
Van-der-waals TM5 L 245 5x60 H.hbhc K 123 H.hbhc.02
Aromatic TM5 F 238 5x53 H.HF R 184 H.HF.06
Hydrophobic TM5 F 238 5x53 H.HF R 184 H.HF.06
Van-der-waals TM5 F 238 5x53 H.HF R 184 H.HF.06
Hydrophobic ICL2 P 129 34x54 G.hns1 G 41 G.hns1.03
Hydrophobic TM5 Y 215 5x31 G.S6 F 340 G.S6.02
Hydrophobic ECL2 V 205 - G.H5 I 371 G.H5.23
Polar TM5 E 240 5x55 G.s4h3 Q 240 G.s4h3.06
Van-der-waals TM5 E 240 5x55 G.s4h3 Q 240 G.s4h3.06
Polar TM5 D 242 5x57 H.hdhe L 156 H.hdhe.03
Hydrophobic TM5 D 242 5x57 H.hdhe L 156 H.hdhe.03
Van-der-waals TM5 D 242 5x57 H.hdhe L 156 H.hdhe.03
Polar TM5 R 244 5x59 H.HA P 80 H.HA.09
Hydrophobic TM5 R 244 5x59 H.HA P 80 H.HA.09
Van-der-waals TM5 R 244 5x59 H.HA P 80 H.HA.09
Hydrophobic TM5 V 227 5x43 G.H4 R 310 G.H4.09
Van-der-waals TM5 V 227 5x43 G.H4 R 310 G.H4.09
Hydrophobic TM5 L 241 5x56 H.HE S 159 H.HE.01
Van-der-waals TM5 L 241 5x56 H.HE S 159 H.HE.01
Hydrophobic TM5 R 237 5x52 H.HE V 161 H.HE.03
Polar ICL2 K 126 34x51 G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 K 126 34x51 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 K 126 34x51 G.s2s3 K 201 G.s2s3.02
Polar TM5 Q 239 5x54 H.HD Y 148 H.HD.07
Van-der-waals TM5 Q 239 5x54 H.HD Y 148 H.HD.07
Hydrophobic TM6 G 315 6x31 G.H5 I 371 G.H5.23
Van-der-waals TM6 G 315 6x31 G.H5 I 371 G.H5.23
Hydrophobic ECL2 L 212 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ECL2 L 212 - G.h4s6 R 338 G.h4s6.20
Hydrophobic TM3 I 122 3x54 G.H5 I 371 G.H5.23
Van-der-waals TM3 I 122 3x54 G.H5 I 371 G.H5.23
Polar TM5 Q 239 5x54 H.HE Y 162 H.HE.04
Hydrophobic TM5 Q 239 5x54 H.HE Y 162 H.HE.04
Van-der-waals TM5 Q 239 5x54 H.HE Y 162 H.HE.04
Hydrophobic TM5 T 230 5x46 G.H4 A 307 G.H4.06
Hydrophobic TM5 L 241 5x56 H.hdhe L 157 H.hdhe.04
Van-der-waals TM5 L 241 5x56 H.hdhe L 157 H.hdhe.04
Hydrophobic TM5 R 244 5x59 H.HB P 121 H.HB.14
Van-der-waals TM5 R 244 5x59 H.HB P 121 H.HB.14
Hydrophobic TM6 F 314 6x30 G.H5 E 370 G.H5.22
Van-der-waals TM6 F 314 6x30 G.H5 E 370 G.H5.22
Hydrophobic TM5 L 241 5x56 G.hfs2 S 185 G.hfs2.01
Van-der-waals TM5 L 241 5x56 G.hfs2 S 185 G.hfs2.01
Polar TM5 F 238 5x53 G.HG E 284 G.HG.06
Hydrophobic TM5 P 235 5x50 G.HG P 287 G.HG.09
Hydrophobic TM5 H 223 5x39 G.H4 L 313 G.H4.12
Van-der-waals TM5 H 223 5x39 G.H4 L 313 G.H4.12
Hydrophobic TM2 R 54 2x38 G.HN L 33 G.HN.48
Van-der-waals TM2 R 54 2x38 G.HN L 33 G.HN.48
Polar TM5 S 243 5x58 H.HA N 85 H.HA.14
Hydrophobic TM5 S 243 5x58 H.HA N 85 H.HA.14
Van-der-waals TM5 S 243 5x58 H.HA N 85 H.HA.14
Hydrophobic TM5 F 238 5x53 H.hdhe D 158 H.hdhe.05
Hydrophobic TM5 L 241 5x56 G.hfs2 R 186 G.hfs2.02
Van-der-waals TM5 L 241 5x56 G.hfs2 R 186 G.hfs2.02
Polar TM6 K 316 6x32 G.H5 E 370 G.H5.22
Van-der-waals TM6 K 316 6x32 G.H5 E 370 G.H5.22
Hydrophobic TM5 E 240 5x55 H.hdhe D 158 H.hdhe.05
Van-der-waals TM5 E 240 5x55 H.hdhe D 158 H.hdhe.05
Polar TM6 S 311 6x27 G.h4s6 S 336 G.h4s6.18
Hydrophobic ECL2 A 208 - G.H5 L 364 G.H5.16
Van-der-waals ECL2 A 208 - G.H5 L 364 G.H5.16
Hydrophobic TM6 S 311 6x27 G.H5 E 370 G.H5.22
Van-der-waals TM6 S 311 6x27 G.H5 E 370 G.H5.22
Polar TM6 D 309 6x25 G.h3s5 S 269 G.h3s5.02
Hydrophobic TM6 D 309 6x25 G.h3s5 S 269 G.h3s5.02
Van-der-waals TM6 D 309 6x25 G.h3s5 S 269 G.h3s5.02
Hydrophobic TM5 E 240 5x55 H.hdhe L 156 H.hdhe.03
Van-der-waals TM5 E 240 5x55 H.hdhe L 156 H.hdhe.03
Hydrophobic TM5 L 241 5x56 H.HF R 184 H.HF.06
Van-der-waals TM5 L 241 5x56 H.HF R 184 H.HF.06
Polar TM5 Y 215 5x31 G.S6 H 342 G.S6.04
Hydrophobic TM5 Y 215 5x31 G.S6 H 342 G.S6.04
Van-der-waals TM5 Y 215 5x31 G.S6 H 342 G.S6.04
Polar TM5 Q 219 5x35 G.S6 S 341 G.S6.03
Van-der-waals TM5 Q 219 5x35 G.S6 S 341 G.S6.03
Polar TM5 Q 239 5x54 H.HE S 159 H.HE.01
Hydrophobic TM5 Q 239 5x54 H.HE S 159 H.HE.01
Van-der-waals TM5 Q 239 5x54 H.HE S 159 H.HE.01
Hydrophobic ECL2 A 209 - G.H5 L 368 G.H5.20
Hydrophobic TM5 G 236 5x51 G.HG E 284 G.HG.06
Van-der-waals TM5 G 236 5x51 G.HG E 284 G.HG.06
Hydrophobic TM5 L 241 5x56 H.HE Y 163 H.HE.05
Van-der-waals TM5 L 241 5x56 H.HE Y 163 H.HE.05
Hydrophobic TM5 D 242 5x57 H.hdhe H 155 H.hdhe.02
Van-der-waals TM5 D 242 5x57 H.hdhe H 155 H.hdhe.02
Hydrophobic TM5 F 238 5x53 G.HG D 280 G.HG.02
Van-der-waals TM5 F 238 5x53 G.HG D 280 G.HG.02
Hydrophobic ECL2 I 201 - G.H5 I 371 G.H5.23
Hydrophobic TM5 S 243 5x58 H.hdhe L 157 H.hdhe.04
Van-der-waals TM5 S 243 5x58 H.hdhe L 157 H.hdhe.04
Hydrophobic TM5 L 245 5x60 H.HB P 121 H.HB.14
Van-der-waals TM5 L 245 5x60 H.HB P 121 H.HB.14
Polar TM5 I 222 5x38 G.H4 R 310 G.H4.09
Van-der-waals TM5 I 222 5x38 G.H4 R 310 G.H4.09
Hydrophobic TM6 T 318 6x34 G.H5 I 371 G.H5.23
Van-der-waals TM6 T 318 6x34 G.H5 I 371 G.H5.23
Polar TM5 D 242 5x57 H.HA V 88 H.HA.17
Hydrophobic TM5 D 242 5x57 H.HA V 88 H.HA.17
Van-der-waals TM5 D 242 5x57 H.HA V 88 H.HA.17
Polar TM5 S 224 5x40 G.H4 R 310 G.H4.09
Hydrophobic TM5 S 224 5x40 G.H4 R 310 G.H4.09
Van-der-waals TM5 S 224 5x40 G.H4 R 310 G.H4.09
Polar TM5 D 242 5x57 H.hdhe L 157 H.hdhe.04
Hydrophobic TM5 D 242 5x57 H.hdhe L 157 H.hdhe.04
Van-der-waals TM5 D 242 5x57 H.hdhe L 157 H.hdhe.04
Hydrophobic TM5 L 241 5x56 H.hdhe D 158 H.hdhe.05
Van-der-waals TM5 L 241 5x56 H.hdhe D 158 H.hdhe.05
Polar TM5 S 243 5x58 G.hfs2 R 186 G.hfs2.02
Van-der-waals TM5 S 243 5x58 G.hfs2 R 186 G.hfs2.02
Hydrophobic TM5 E 240 5x55 H.HE S 159 H.HE.01
Van-der-waals TM5 E 240 5x55 H.HE S 159 H.HE.01
Hydrophobic TM6 S 311 6x27 G.H5 R 366 G.H5.18
Van-der-waals TM6 S 311 6x27 G.H5 R 366 G.H5.18
Polar TM5 E 240 5x55 H.HE A 160 H.HE.02
Hydrophobic TM5 E 240 5x55 H.HE A 160 H.HE.02
Van-der-waals TM5 E 240 5x55 H.HE A 160 H.HE.02
Hydrophobic TM5 R 244 5x59 H.HA V 88 H.HA.17
Van-der-waals TM5 R 244 5x59 H.HA V 88 H.HA.17
Hydrophobic TM3 L 121 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 L 121 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 I 122 3x54 G.H5 Y 367 G.H5.19
Van-der-waals TM3 I 122 3x54 G.H5 Y 367 G.H5.19
Hydrophobic TM5 A 246 5x61 H.hbhc Y 122 H.hbhc.01
Van-der-waals TM5 A 246 5x61 H.hbhc Y 122 H.hbhc.01
Polar C-term H 396 - G.HN R 8 G.HN.08
Hydrophobic C-term H 396 - G.HN R 8 G.HN.08
Van-der-waals C-term H 396 - G.HN R 8 G.HN.08
Polar TM5 D 242 5x57 H.HA N 85 H.HA.14
Hydrophobic TM5 D 242 5x57 H.HA N 85 H.HA.14
Van-der-waals TM5 D 242 5x57 H.HA N 85 H.HA.14
Polar ICL2 K 126 34x51 G.s2s3 Q 200 G.s2s3.01
Van-der-waals ICL2 K 126 34x51 G.s2s3 Q 200 G.s2s3.01
Ionic TM5 H 226 5x42 G.H4 E 306 G.H4.05
Polar TM5 H 226 5x42 G.H4 E 306 G.H4.05
Hydrophobic TM5 H 226 5x42 G.H4 E 306 G.H4.05
Van-der-waals TM5 H 226 5x42 G.H4 E 306 G.H4.05
Polar TM5 R 244 5x59 H.hbhc Y 122 H.hbhc.01
Hydrophobic TM5 R 244 5x59 H.hbhc Y 122 H.hbhc.01
Van-der-waals TM5 R 244 5x59 H.hbhc Y 122 H.hbhc.01
Polar TM5 F 238 5x53 H.HD Y 148 H.HD.07
Hydrophobic TM5 F 238 5x53 H.HD Y 148 H.HD.07
Van-der-waals TM5 F 238 5x53 H.HD Y 148 H.HD.07
Ionic TM5 R 237 5x52 G.HG E 284 G.HG.06
Polar TM5 R 237 5x52 G.HG E 284 G.HG.06
Hydrophobic TM5 R 237 5x52 G.HG E 284 G.HG.06
Van-der-waals TM5 R 237 5x52 G.HG E 284 G.HG.06
Hydrophobic ECL2 V 205 - G.H5 L 373 G.H5.25
Van-der-waals ECL2 V 205 - G.H5 L 373 G.H5.25
Polar TM5 Y 215 5x31 G.S6 S 341 G.S6.03
Van-der-waals TM5 Y 215 5x31 G.S6 S 341 G.S6.03
Polar TM5 Q 239 5x54 H.HE A 160 H.HE.02
Hydrophobic TM5 Q 239 5x54 H.HE A 160 H.HE.02
Van-der-waals TM5 Q 239 5x54 H.HE A 160 H.HE.02
Polar TM5 G 236 5x51 G.HG D 280 G.HG.02
Van-der-waals TM5 G 236 5x51 G.HG D 280 G.HG.02
Polar TM6 R 319 6x35 G.H5 N 372 G.H5.24
Hydrophobic TM6 R 319 6x35 G.H5 N 372 G.H5.24
Van-der-waals TM6 R 319 6x35 G.H5 N 372 G.H5.24
Hydrophobic TM6 F 314 6x30 G.H5 Y 367 G.H5.19
Hydrophobic TM3 I 122 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 I 122 3x54 G.H5 L 364 G.H5.16
Polar TM5 Q 239 5x54 H.HE V 161 H.HE.03
Hydrophobic TM5 Q 239 5x54 H.HE V 161 H.HE.03
Van-der-waals TM5 Q 239 5x54 H.HE V 161 H.HE.03
Hydrophobic TM5 D 242 5x57 H.HA A 92 H.HA.21
Van-der-waals TM5 D 242 5x57 H.HA A 92 H.HA.21
Polar ICL2 K 126 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL2 K 126 34x51 G.S3 T 202 G.S3.01
Van-der-waals ICL2 K 126 34x51 G.S3 T 202 G.S3.01
Hydrophobic TM5 L 245 5x60 H.hbhc Y 122 H.hbhc.01
Van-der-waals TM5 L 245 5x60 H.hbhc Y 122 H.hbhc.01
Hydrophobic ECL2 H 202 - G.H5 L 373 G.H5.25
Hydrophobic ECL2 A 208 - G.H5 L 368 G.H5.20
Hydrophobic TM5 T 230 5x46 G.H4 E 306 G.H4.05
Polar TM5 F 238 5x53 H.HD R 151 H.HD.10
Hydrophobic TM5 F 238 5x53 H.HD R 151 H.HD.10
Van-der-waals TM5 F 238 5x53 H.HD R 151 H.HD.10
Hydrophobic TM5 R 237 5x52 H.HD R 145 H.HD.04
Van-der-waals TM5 R 237 5x52 H.HD R 145 H.HD.04
Hydrophobic TM5 L 245 5x60 H.HB D 120 H.HB.13
Van-der-waals TM5 L 245 5x60 H.HB D 120 H.HB.13
Hydrophobic TM5 R 244 5x59 H.HA L 81 H.HA.10
Van-der-waals TM5 R 244 5x59 H.HA L 81 H.HA.10
Hydrophobic C-term L 395 - G.HN W 7 G.HN.07
Van-der-waals C-term L 395 - G.HN W 7 G.HN.07
Polar TM5 H 226 5x42 G.H4 R 310 G.H4.09
Hydrophobic TM5 H 226 5x42 G.H4 R 310 G.H4.09
Van-der-waals TM5 H 226 5x42 G.H4 R 310 G.H4.09
Hydrophobic TM5 P 235 5x50 G.HG E 284 G.HG.06
Van-der-waals TM5 P 235 5x50 G.HG E 284 G.HG.06
Polar TM5 E 240 5x55 H.hdhe L 157 H.hdhe.04
Hydrophobic TM5 E 240 5x55 H.hdhe L 157 H.hdhe.04
Van-der-waals TM5 E 240 5x55 H.hdhe L 157 H.hdhe.04
Polar TM6 G 315 6x31 G.H5 E 370 G.H5.22
Hydrophobic TM6 G 315 6x31 G.H5 E 370 G.H5.22
Van-der-waals TM6 G 315 6x31 G.H5 E 370 G.H5.22
Hydrophobic TM5 F 238 5x53 G.HG I 281 G.HG.03
Van-der-waals TM5 F 238 5x53 G.HG I 281 G.HG.03
Polar TM5 R 244 5x59 H.HA Q 84 H.HA.13
Hydrophobic TM5 R 244 5x59 H.HA Q 84 H.HA.13
Van-der-waals TM5 R 244 5x59 H.HA Q 84 H.HA.13
Polar TM5 D 242 5x57 H.HA S 89 H.HA.18
Hydrophobic TM5 D 242 5x57 H.HA S 89 H.HA.18
Van-der-waals TM5 D 242 5x57 H.HA S 89 H.HA.18
Hydrophobic TM5 F 238 5x53 G.s6h5 A 346 G.s6h5.03
Polar TM5 S 243 5x58 H.hbhc Y 122 H.hbhc.01
Hydrophobic TM5 R 237 5x52 H.HD Y 148 H.HD.07
Hydrophobic TM5 T 230 5x46 G.H4 D 304 G.H4.03
Van-der-waals TM5 T 230 5x46 G.H4 D 304 G.H4.03
Hydrophobic TM5 S 243 5x58 H.HA V 88 H.HA.17
Van-der-waals TM5 S 243 5x58 H.HA V 88 H.HA.17
Hydrophobic ICL2 K 126 34x51 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 F 128 34x53 G.hns1 R 40 G.hns1.02
Hydrophobic ECL2 L 212 - G.S6 F 340 G.S6.02
Polar TM6 S 311 6x27 G.h3s5 S 269 G.h3s5.02
Hydrophobic ECL2 V 205 - G.H5 L 368 G.H5.20
Van-der-waals ECL2 V 205 - G.H5 L 368 G.H5.20
Polar TM6 R 319 6x35 G.H5 I 371 G.H5.23
Hydrophobic TM6 R 319 6x35 G.H5 I 371 G.H5.23
Van-der-waals TM6 R 319 6x35 G.H5 I 371 G.H5.23
Hydrophobic TM5 Q 239 5x54 H.hdhe D 158 H.hdhe.05
Van-der-waals TM5 Q 239 5x54 H.hdhe D 158 H.hdhe.05
Hydrophobic TM5 L 241 5x56 H.HE A 160 H.HE.02
Van-der-waals TM5 L 241 5x56 H.HE A 160 H.HE.02
Polar TM5 E 240 5x55 H.HA S 89 H.HA.18
Hydrophobic ICL2 P 129 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals TM5 Y 215 5x31 G.H5 K 357 G.H5.09
Ionic TM5 E 240 5x55 H.HD R 151 H.HD.10
Polar TM5 E 240 5x55 H.HD R 151 H.HD.10
Hydrophobic TM5 E 240 5x55 H.HD R 151 H.HD.10
Van-der-waals TM5 E 240 5x55 H.HD R 151 H.HD.10
Polar TM5 S 247 5x62 H.HB D 120 H.HB.13
Hydrophobic TM5 S 247 5x62 H.HB D 120 H.HB.13
Van-der-waals TM5 S 247 5x62 H.HB D 120 H.HB.13
Ionic TM5 R 237 5x52 H.HD E 149 H.HD.08
Polar TM5 R 237 5x52 H.HD E 149 H.HD.08
Van-der-waals TM5 R 237 5x52 H.HD E 149 H.HD.08