Gi1 - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals ICL2 P 125 34x50 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 F 314 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 F 314 6x30 G.H5 K 345 G.H5.17
Ionic TM5 H 223 5x39 G.H4 E 297 G.H4.04
Aromatic TM5 Y 215 5x31 G.H5 F 334 G.H5.06
Hydrophobic TM5 Y 215 5x31 G.H5 F 334 G.H5.06
Van-der-waals TM5 Y 215 5x31 G.H5 F 334 G.H5.06
Polar TM2 R 54 2x38 G.HN L 23 G.HN.47
Hydrophobic TM2 R 54 2x38 G.HN L 23 G.HN.47
Van-der-waals TM2 R 54 2x38 G.HN L 23 G.HN.47
Polar H8 N 374 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 F 314 6x30 G.H5 F 354 G.H5.26
Polar ICL2 L 127 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 127 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 127 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 M 320 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 320 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 129 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 129 34x54 G.hns1 R 32 G.hns1.03
Ionic ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM4 K 135 4x40 G.HN R 24 G.HN.48
Hydrophobic TM3 L 121 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 121 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 317 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 317 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 121 3x53 G.hns1 A 31 G.hns1.02
Ionic ICL1 K 50 12x49 G.h3s5 D 261 G.h3s5.02
Polar ICL1 K 50 12x49 G.h3s5 D 261 G.h3s5.02
Hydrophobic ICL1 K 50 12x49 G.h3s5 D 261 G.h3s5.02
Van-der-waals ICL1 K 50 12x49 G.h3s5 D 261 G.h3s5.02
Hydrophobic TM4 S 133 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 133 4x38 G.HN E 28 G.HN.52
Polar ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 126 34x51 G.S3 H 195 G.S3.02
Van-der-waals ICL2 K 126 34x51 G.S3 H 195 G.S3.02
Hydrophobic ICL2 P 129 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 E 313 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 E 313 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 125 34x50 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 P 125 34x50 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 I 122 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 122 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 129 34x54 G.HN E 28 G.HN.52
Van-der-waals ICL2 P 129 34x54 G.HN E 28 G.HN.52
Hydrophobic ECL2 L 212 - G.H5 A 338 G.H5.10
Ionic TM6 E 313 6x29 G.H5 K 349 G.H5.21
Polar TM6 E 313 6x29 G.H5 K 349 G.H5.21
Hydrophobic TM6 E 313 6x29 G.H5 K 349 G.H5.21
Van-der-waals TM6 E 313 6x29 G.H5 K 349 G.H5.21
Polar TM6 S 310 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 S 310 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 310 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 E 313 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 313 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 317 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 317 6x33 G.H5 F 354 G.H5.26
Polar H8 Q 376 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL2 F 128 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 128 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals H8 R 375 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 C 321 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 C 321 6x37 G.H5 L 353 G.H5.25
Polar ICL2 P 125 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 125 34x50 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 125 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 L 121 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 126 34x51 G.S2 T 190 G.S2.07
Van-der-waals ICL2 K 126 34x51 G.S2 T 190 G.S2.07
Hydrophobic TM6 K 316 6x32 G.H5 F 354 G.H5.26
Polar H8 N 374 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 N 374 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 N 374 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM3 L 121 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 54 2x38 G.HN G 27 G.HN.51
Van-der-waals TM2 R 54 2x38 G.HN G 27 G.HN.51
Polar TM2 R 54 2x38 G.HN R 24 G.HN.48
Hydrophobic TM2 R 54 2x38 G.HN R 24 G.HN.48
Ionic TM3 H 124 3x56 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Polar ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 125 34x50 G.S3 L 194 G.S3.01
Van-der-waals ICL2 P 125 34x50 G.S3 L 194 G.S3.01
Hydrophobic TM2 F 55 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 55 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 H 223 5x39 G.H4 Y 296 G.H4.03
Polar TM3 R 118 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 118 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 118 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 118 3x50 G.H5 L 353 G.H5.25