Gi2 - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 317 6x33 G.H5 F 355 G.H5.26
Van-der-waals TM6 V 317 6x33 G.H5 F 355 G.H5.26
Ionic TM3 H 124 3x56 G.s2s3 D 194 G.s2s3.02
Polar TM3 H 124 3x56 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM3 H 124 3x56 G.s2s3 D 194 G.s2s3.02
Van-der-waals TM3 H 124 3x56 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM5 H 223 5x39 G.H4 Y 297 G.H4.03
Van-der-waals TM5 H 223 5x39 G.H4 Y 297 G.H4.03
Hydrophobic TM5 Y 215 5x31 G.H5 V 336 G.H5.07
Van-der-waals TM5 Y 215 5x31 G.H5 V 336 G.H5.07
Hydrophobic TM3 L 121 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 L 121 3x53 G.H5 L 349 G.H5.20
Polar ICL2 K 126 34x51 G.S2 T 191 G.S2.07
Hydrophobic ICL2 K 126 34x51 G.S2 T 191 G.S2.07
Van-der-waals ICL2 K 126 34x51 G.S2 T 191 G.S2.07
Polar ICL2 L 127 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 127 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 127 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 F 55 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 55 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM5 R 218 5x34 G.H5 F 335 G.H5.06
Hydrophobic ICL2 P 129 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 129 34x54 G.hns1 R 32 G.hns1.03
Polar H8 N 374 8x47 G.H5 G 353 G.H5.24
Aromatic TM5 Y 215 5x31 G.H5 F 335 G.H5.06
Hydrophobic TM5 Y 215 5x31 G.H5 F 335 G.H5.06
Van-der-waals TM5 Y 215 5x31 G.H5 F 335 G.H5.06
Hydrophobic TM3 L 121 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 125 34x50 G.S3 L 195 G.S3.01
Van-der-waals ICL2 P 125 34x50 G.S3 L 195 G.S3.01
Hydrophobic TM4 K 135 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 K 135 4x40 G.HN R 24 G.HN.48
Hydrophobic ECL2 A 208 - G.H5 D 342 G.H5.13
Hydrophobic TM3 L 121 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 V 227 5x43 G.H4 D 298 G.H4.04
Van-der-waals TM5 V 227 5x43 G.H4 D 298 G.H4.04
Polar TM5 Y 215 5x31 G.S6 H 323 G.S6.04
Hydrophobic TM5 Y 215 5x31 G.S6 H 323 G.S6.04
Hydrophobic TM6 M 320 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 320 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 122 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 122 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM4 S 133 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 133 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 K 316 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 316 6x32 G.H5 F 355 G.H5.26
Polar ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 126 34x51 G.S3 L 195 G.S3.01
Polar TM4 A 134 4x39 G.HN R 24 G.HN.48
Hydrophobic TM4 A 134 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 A 134 4x39 G.HN R 24 G.HN.48
Ionic ICL1 K 50 12x49 G.h3s5 D 262 G.h3s5.02
Polar ICL1 K 50 12x49 G.h3s5 D 262 G.h3s5.02
Hydrophobic ICL1 K 50 12x49 G.h3s5 D 262 G.h3s5.02
Van-der-waals ICL1 K 50 12x49 G.h3s5 D 262 G.h3s5.02
Ionic TM5 H 226 5x42 G.HG E 276 G.HG.05
Polar TM5 H 226 5x42 G.HG E 276 G.HG.05
Hydrophobic TM5 H 226 5x42 G.HG E 276 G.HG.05
Van-der-waals TM5 H 226 5x42 G.HG E 276 G.HG.05
Polar TM6 S 310 6x26 G.H5 K 346 G.H5.17
Hydrophobic TM6 S 310 6x26 G.H5 K 346 G.H5.17
Van-der-waals TM6 S 310 6x26 G.H5 K 346 G.H5.17
Hydrophobic ICL2 P 129 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 C 321 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 C 321 6x37 G.H5 L 354 G.H5.25
Polar TM4 A 134 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 A 134 4x39 G.HN E 28 G.HN.52
Hydrophobic TM6 E 313 6x29 G.H5 K 346 G.H5.17
Van-der-waals TM6 E 313 6x29 G.H5 K 346 G.H5.17
Hydrophobic ICL2 P 129 34x54 G.HN E 28 G.HN.52
Van-der-waals ICL2 P 129 34x54 G.HN E 28 G.HN.52
Polar ICL2 K 126 34x51 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 K 126 34x51 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 K 126 34x51 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM6 V 317 6x33 G.H5 L 354 G.H5.25
Polar H8 N 374 8x47 G.H5 F 355 G.H5.26
Hydrophobic H8 N 374 8x47 G.H5 F 355 G.H5.26
Van-der-waals H8 N 374 8x47 G.H5 F 355 G.H5.26
Hydrophobic H8 Q 376 8x49 G.H5 F 355 G.H5.26
Ionic TM6 E 313 6x29 G.H5 K 350 G.H5.21
Polar TM6 E 313 6x29 G.H5 K 350 G.H5.21
Hydrophobic TM6 E 313 6x29 G.H5 K 350 G.H5.21
Van-der-waals TM6 E 313 6x29 G.H5 K 350 G.H5.21
Polar ICL2 K 126 34x51 G.S3 H 196 G.S3.02
Hydrophobic ICL2 K 126 34x51 G.S3 H 196 G.S3.02
Van-der-waals ICL2 K 126 34x51 G.S3 H 196 G.S3.02
Hydrophobic ICL2 F 128 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic ECL2 L 212 - G.H5 A 339 G.H5.10
Ionic TM5 H 223 5x39 G.H4 D 298 G.H4.04
Polar TM5 H 223 5x39 G.H4 D 298 G.H4.04
Van-der-waals TM5 H 223 5x39 G.H4 D 298 G.H4.04
Hydrophobic TM5 Y 215 5x31 G.H5 A 339 G.H5.10
Polar ICL2 P 125 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 125 34x50 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 125 34x50 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 128 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 R 118 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 118 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM6 E 313 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 E 313 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 F 314 6x30 G.H5 K 346 G.H5.17
Van-der-waals TM6 F 314 6x30 G.H5 K 346 G.H5.17
Polar TM2 R 54 2x38 G.HN R 24 G.HN.48
Hydrophobic TM2 R 54 2x38 G.HN R 24 G.HN.48
Van-der-waals TM2 R 54 2x38 G.HN R 24 G.HN.48
Polar ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals H8 R 375 8x48 G.H5 F 355 G.H5.26
Polar ICL2 P 125 34x50 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 P 125 34x50 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 P 125 34x50 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM6 F 314 6x30 G.H5 L 349 G.H5.20
Ionic TM2 R 54 2x38 G.HN E 28 G.HN.52
Polar TM2 R 54 2x38 G.HN E 28 G.HN.52
Van-der-waals TM2 R 54 2x38 G.HN E 28 G.HN.52
Polar TM3 R 118 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 118 3x50 G.H5 G 353 G.H5.24