Gi3 - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 17.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ECL2 L 212 - G.H5 D 341 G.H5.13
Hydrophobic TM6 P 308 6x24 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 P 308 6x24 G.h4s6 D 315 G.h4s6.09
Polar TM5 H 226 5x42 G.H4 E 297 G.H4.04
Hydrophobic TM5 H 226 5x42 G.H4 E 297 G.H4.04
Van-der-waals TM5 H 226 5x42 G.H4 E 297 G.H4.04
Polar TM5 Y 215 5x31 G.S6 T 321 G.S6.03
Van-der-waals TM5 Y 215 5x31 G.S6 T 321 G.S6.03
Hydrophobic TM6 F 314 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 F 314 6x30 G.H5 L 348 G.H5.20
Polar H8 N 374 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 374 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 G 352 G.H5.24
Polar TM5 H 223 5x39 G.H4 A 301 G.H4.08
Hydrophobic TM5 H 223 5x39 G.H4 A 301 G.H4.08
Van-der-waals TM5 H 223 5x39 G.H4 A 301 G.H4.08
Hydrophobic TM6 F 314 6x30 G.H5 I 344 G.H5.16
Hydrophobic ECL2 V 205 - G.H5 L 348 G.H5.20
Polar TM5 Y 215 5x31 G.S6 H 322 G.S6.04
Aromatic TM5 Y 215 5x31 G.S6 H 322 G.S6.04
Hydrophobic TM5 Y 215 5x31 G.S6 H 322 G.S6.04
Van-der-waals TM5 Y 215 5x31 G.S6 H 322 G.S6.04
Hydrophobic TM6 M 320 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 320 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 F 238 5x53 G.hgh4 P 288 G.hgh4.03
Hydrophobic ECL2 L 212 - G.S6 Y 320 G.S6.02
Van-der-waals ECL2 L 212 - G.S6 Y 320 G.S6.02
Polar H8 Q 376 8x49 G.H5 K 349 G.H5.21
Hydrophobic ECL2 L 212 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ECL2 L 212 - G.h4s6 E 318 G.h4s6.12
Ionic ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 H 223 5x39 G.H4 Q 304 G.H4.12
Van-der-waals TM5 H 223 5x39 G.H4 Q 304 G.H4.12
Hydrophobic TM5 T 230 5x46 G.hgh4 T 291 G.hgh4.06
Hydrophobic TM3 I 122 3x54 G.H5 L 353 G.H5.25
Polar TM6 V 317 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 317 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 317 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 H 226 5x42 G.H4 A 301 G.H4.08
Polar TM6 S 310 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 310 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 T 230 5x46 G.hgh4 G 292 G.hgh4.07
Hydrophobic ECL2 A 208 - G.H5 I 344 G.H5.16
Ionic TM6 E 313 6x29 G.H5 K 345 G.H5.17
Polar TM6 E 313 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 E 313 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 E 313 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 V 317 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 V 317 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 122 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 122 3x54 G.H5 L 348 G.H5.20
Polar ICL2 K 126 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 K 126 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 K 126 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 126 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 F 238 5x53 G.hgh4 E 289 G.hgh4.04
Polar TM6 E 313 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 E 313 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 E 313 6x29 G.H5 Y 354 G.H5.26
Polar H8 R 375 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 R 375 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 R 375 8x48 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 125 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 125 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 C 321 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 C 321 6x37 G.H5 L 353 G.H5.25
Polar TM3 L 121 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 121 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 121 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 M 320 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 320 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 125 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 P 235 5x50 G.hgh4 T 291 G.hgh4.06
Van-der-waals TM5 P 235 5x50 G.hgh4 T 291 G.hgh4.06
Hydrophobic TM3 L 121 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM2 F 55 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 55 2x39 G.H5 C 351 G.H5.23
Polar TM5 Q 219 5x35 G.S6 T 321 G.S6.03
Van-der-waals TM5 Q 219 5x35 G.S6 T 321 G.S6.03
Ionic TM5 H 226 5x42 G.H4 E 298 G.H4.05
Polar TM5 H 226 5x42 G.H4 E 298 G.H4.05
Hydrophobic TM5 H 226 5x42 G.H4 E 298 G.H4.05
Van-der-waals TM5 H 226 5x42 G.H4 E 298 G.H4.05
Ionic TM5 K 216 5x32 G.h4s6 E 318 G.h4s6.12
Polar TM5 K 216 5x32 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 K 216 5x32 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 K 216 5x32 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 118 3x50 G.H5 L 353 G.H5.25
Polar TM5 A 233 5x48 G.hgh4 T 291 G.hgh4.06
Hydrophobic TM5 A 233 5x48 G.hgh4 T 291 G.hgh4.06
Polar TM3 R 118 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 118 3x50 G.H5 C 351 G.H5.23
Ionic TM2 R 54 2x38 G.HN E 28 G.HN.52
Polar TM2 R 54 2x38 G.HN E 28 G.HN.52
Hydrophobic TM2 R 54 2x38 G.HN E 28 G.HN.52
Van-der-waals TM2 R 54 2x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 129 34x54 G.hns1 K 32 G.hns1.03