Golf - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 Y 215 5x31 G.S6 P 348 G.S6.03
Van-der-waals TM5 Y 215 5x31 G.S6 P 348 G.S6.03
Van-der-waals ECL2 A 208 - G.H5 D 368 G.H5.13
Hydrophobic TM6 F 314 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 F 314 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM6 M 320 6x36 G.H5 E 379 G.H5.24
Polar H8 N 374 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 N 374 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 E 379 G.H5.24
Polar TM6 S 310 6x26 G.H5 R 372 G.H5.17
Hydrophobic H8 N 374 8x47 G.H5 L 381 G.H5.26
Hydrophobic TM6 M 320 6x36 G.H5 L 381 G.H5.26
Van-der-waals TM6 M 320 6x36 G.H5 L 381 G.H5.26
Hydrophobic ECL2 V 205 - G.H5 L 375 G.H5.20
Van-der-waals ECL2 V 205 - G.H5 L 375 G.H5.20
Polar TM3 R 118 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 118 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 118 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM6 F 314 6x30 G.H5 R 372 G.H5.17
Van-der-waals TM6 F 314 6x30 G.H5 R 372 G.H5.17
Polar TM5 Y 215 5x31 G.S6 H 349 G.S6.04
Hydrophobic TM5 Y 215 5x31 G.S6 H 349 G.S6.04
Van-der-waals TM5 Y 215 5x31 G.S6 H 349 G.S6.04
Hydrophobic TM3 L 121 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM3 I 122 3x54 G.H5 L 380 G.H5.25
Van-der-waals TM3 I 122 3x54 G.H5 L 380 G.H5.25
Polar H8 Q 376 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 Q 376 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 Q 376 8x49 G.H5 E 379 G.H5.24
Hydrophobic TM2 F 55 2x39 G.H5 Y 378 G.H5.23
Polar ECL2 Q 204 - G.H5 Q 371 G.H5.16
Hydrophobic TM5 A 220 5x36 G.hgh4 P 308 G.hgh4.11
Hydrophobic TM6 V 324 6x40 G.H5 L 381 G.H5.26
Van-der-waals TM6 V 324 6x40 G.H5 L 381 G.H5.26
Hydrophobic ICL2 F 128 34x53 G.H5 Y 378 G.H5.23
Hydrophobic TM7 L 369 7x52 G.H5 L 381 G.H5.26
Van-der-waals TM7 L 369 7x52 G.H5 L 381 G.H5.26
Hydrophobic TM5 L 217 5x33 G.H4 D 330 G.H4.13
Polar TM3 R 118 3x50 G.H5 L 381 G.H5.26
Hydrophobic TM3 R 118 3x50 G.H5 L 381 G.H5.26
Van-der-waals TM3 R 118 3x50 G.H5 L 381 G.H5.26
Polar TM5 S 221 5x37 G.hgh4 T 306 G.hgh4.09
Hydrophobic TM5 L 217 5x33 G.H4 L 333 G.H4.16
Van-der-waals TM5 L 217 5x33 G.H4 L 333 G.H4.16
Hydrophobic ECL2 L 212 - G.S6 Y 347 G.S6.02
Van-der-waals ECL2 L 212 - G.S6 Y 347 G.S6.02
Hydrophobic TM6 M 320 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 320 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 122 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 122 3x54 G.H5 L 375 G.H5.20
Aromatic TM5 Y 215 5x31 G.S6 Y 347 G.S6.02
Hydrophobic TM5 Y 215 5x31 G.S6 Y 347 G.S6.02
Van-der-waals TM5 Y 215 5x31 G.S6 Y 347 G.S6.02
Hydrophobic TM3 L 121 3x53 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 317 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 217 5x33 G.H4 R 334 G.H4.17
Van-der-waals TM5 L 217 5x33 G.H4 R 334 G.H4.17
Polar H8 R 375 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 R 375 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 R 375 8x48 G.H5 E 379 G.H5.24
Polar H8 Q 376 8x49 G.H5 Q 377 G.H5.22
Hydrophobic TM6 P 308 6x24 G.h4s6 G 340 G.h4s6.09
Van-der-waals TM6 P 308 6x24 G.h4s6 G 340 G.h4s6.09
Hydrophobic TM3 L 121 3x53 G.H5 H 374 G.H5.19
Polar TM3 I 122 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 I 122 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 I 122 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM6 S 310 6x26 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 S 310 6x26 G.h4s6 Y 345 G.h4s6.20
Hydrophobic ICL2 P 125 34x50 G.H5 H 374 G.H5.19
Polar ICL2 K 126 34x51 G.s2s3 K 203 G.s2s3.02
Hydrophobic ICL2 K 126 34x51 G.s2s3 K 203 G.s2s3.02
Van-der-waals ICL2 K 126 34x51 G.s2s3 K 203 G.s2s3.02
Ionic TM5 R 218 5x34 G.hgh4 D 310 G.hgh4.13
Polar TM5 R 218 5x34 G.hgh4 D 310 G.hgh4.13
Hydrophobic TM5 R 218 5x34 G.hgh4 D 310 G.hgh4.13
Van-der-waals TM5 R 218 5x34 G.hgh4 D 310 G.hgh4.13
Hydrophobic TM7 Y 370 7x53 G.H5 L 381 G.H5.26
Van-der-waals TM7 Y 370 7x53 G.H5 L 381 G.H5.26
Polar TM5 Y 215 5x31 G.H5 D 365 G.H5.10
Van-der-waals TM5 Y 215 5x31 G.H5 D 365 G.H5.10
Hydrophobic ECL2 L 212 - G.h4s6 Y 345 G.h4s6.20
Van-der-waals ECL2 L 212 - G.h4s6 Y 345 G.h4s6.20
Hydrophobic ICL3 A 307 - G.h4s6 T 337 G.h4s6.03
Hydrophobic TM7 M 373 7x56 G.H5 L 381 G.H5.26
Van-der-waals TM7 M 373 7x56 G.H5 L 381 G.H5.26
Polar ICL2 K 126 34x51 G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 K 126 34x51 G.s2s3 D 202 G.s2s3.01
Hydrophobic TM6 V 317 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 317 6x33 G.H5 L 380 G.H5.25
Polar TM6 C 321 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM5 Y 215 5x31 G.H4 L 333 G.H4.16
Van-der-waals TM5 Y 215 5x31 G.H4 L 333 G.H4.16
Hydrophobic ICL2 K 126 34x51 G.S3 V 204 G.S3.01
Van-der-waals ICL2 K 126 34x51 G.S3 V 204 G.S3.01
Polar ECL2 A 208 - G.H5 R 372 G.H5.17
Hydrophobic ECL2 A 208 - G.H5 R 372 G.H5.17
Van-der-waals ECL2 A 208 - G.H5 R 372 G.H5.17
Hydrophobic ECL2 L 212 - G.H5 R 372 G.H5.17
Van-der-waals ECL2 L 212 - G.H5 R 372 G.H5.17
Hydrophobic TM5 L 217 5x33 G.h4s6 T 337 G.h4s6.03