Ggust - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 S 311 6x27 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 311 6x27 G.H5 K 345 G.H5.17
Hydrophobic TM6 F 314 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 F 314 6x30 G.H5 K 345 G.H5.17
Ionic H8 R 375 8x48 G.h4s6 E 315 G.h4s6.09
Polar H8 R 375 8x48 G.h4s6 E 315 G.h4s6.09
Van-der-waals H8 R 375 8x48 G.h4s6 E 315 G.h4s6.09
Ionic TM5 H 223 5x39 G.H4 E 297 G.H4.04
Polar TM5 H 223 5x39 G.H4 E 297 G.H4.04
Van-der-waals TM5 H 223 5x39 G.H4 E 297 G.H4.04
Polar H8 Q 376 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 Q 376 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 Q 376 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM6 F 314 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 F 314 6x30 G.H5 L 348 G.H5.20
Aromatic TM5 Y 215 5x31 G.H5 F 334 G.H5.06
Hydrophobic TM5 Y 215 5x31 G.H5 F 334 G.H5.06
Van-der-waals TM5 Y 215 5x31 G.H5 F 334 G.H5.06
Hydrophobic TM6 F 314 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 F 314 6x30 G.H5 F 354 G.H5.26
Van-der-waals ICL2 L 127 34x52 G.hns1 R 32 G.hns1.03
Polar TM5 Y 215 5x31 G.H5 N 331 G.H5.03
Van-der-waals TM5 Y 215 5x31 G.H5 N 331 G.H5.03
Polar TM6 S 310 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM6 S 310 6x26 G.S6 Y 320 G.S6.02
Van-der-waals TM6 S 310 6x26 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 F 128 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM2 F 55 2x39 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 129 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 129 34x54 G.hns1 R 32 G.hns1.03
Ionic ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 126 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 L 121 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 121 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 317 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 317 6x33 G.H5 L 353 G.H5.25
Polar TM6 S 310 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 310 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 310 6x26 G.h4s6 E 318 G.h4s6.12
Polar ICL2 Q 130 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 Q 130 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 Q 130 34x55 G.HN E 28 G.HN.52
Polar ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 130 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 126 34x51 G.S3 H 195 G.S3.02
Ionic H8 R 375 8x48 G.h4s6 D 316 G.h4s6.10
Hydrophobic ICL2 P 129 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 129 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 T 53 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 53 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 F 55 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 F 55 2x39 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 125 34x50 G.s2s3 D 193 G.s2s3.02
Polar TM2 N 56 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 N 56 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 N 56 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM3 L 121 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 121 3x53 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 122 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 122 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 126 34x51 G.S3 L 194 G.S3.01
Hydrophobic ECL2 L 212 - G.H5 A 338 G.H5.10
Polar TM6 S 310 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 S 310 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 310 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 E 313 6x29 G.H5 K 349 G.H5.21
Hydrophobic TM6 E 313 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 313 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 317 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 317 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM2 T 53 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 122 3x54 G.H5 I 344 G.H5.16
Polar TM2 T 53 2x37 G.H5 G 352 G.H5.24
Hydrophobic TM2 T 53 2x37 G.H5 G 352 G.H5.24
Van-der-waals TM2 T 53 2x37 G.H5 G 352 G.H5.24
Hydrophobic H8 N 374 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 N 374 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM3 L 121 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 H 223 5x39 G.H4 F 296 G.H4.03
Polar ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 126 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 125 34x50 G.S3 L 194 G.S3.01
Hydrophobic TM2 F 55 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 55 2x39 G.H5 C 351 G.H5.23
Polar TM3 R 118 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 118 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 118 3x50 G.H5 L 353 G.H5.25