Gs -
mGlu6 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 14.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
| Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
|---|---|---|---|---|---|---|---|---|
| Hydrophobic | ICL1 | A | 618 | 12x52 | G.H5 | L | 393 | G.H5.25 |
| Van-der-waals | ICL1 | A | 618 | 12x52 | G.H5 | L | 393 | G.H5.25 |
| Hydrophobic | TM3 | I | 678 | 3x57 | G.H5 | H | 387 | G.H5.19 |
| Hydrophobic | TM3 | I | 678 | 3x57 | G.H5 | Q | 384 | G.H5.16 |
| Hydrophobic | ICL2 | K | 683 | - | G.H5 | R | 380 | G.H5.12 |
| Van-der-waals | ICL2 | K | 683 | - | G.H5 | R | 380 | G.H5.12 |
| Hydrophobic | ICL2 | S | 685 | - | G.hns1 | A | 39 | G.hns1.03 |
| Polar | C-term | K | 859 | - | G.hgh4 | T | 319 | G.hgh4.09 |
| Van-der-waals | C-term | K | 859 | - | G.hgh4 | T | 319 | G.hgh4.09 |
| Ionic | H8 | K | 855 | 8x54 | G.H5 | D | 381 | G.H5.13 |
| Hydrophobic | ICL2 | V | 686 | - | G.h2s4 | T | 242 | G.h2s4.05 |
| Hydrophobic | TM3 | I | 678 | 3x57 | G.H5 | L | 388 | G.H5.20 |
| Ionic | TM2 | R | 621 | 2x36 | G.H5 | E | 392 | G.H5.24 |
| Polar | TM2 | R | 621 | 2x36 | G.H5 | E | 392 | G.H5.24 |
| Van-der-waals | TM2 | R | 621 | 2x36 | G.H5 | E | 392 | G.H5.24 |
| Hydrophobic | ICL2 | I | 692 | - | G.H5 | Y | 391 | G.H5.23 |
| Van-der-waals | ICL2 | I | 692 | - | G.H5 | Y | 391 | G.H5.23 |
| Polar | ICL2 | T | 687 | - | G.hns1 | R | 38 | G.hns1.02 |
| Hydrophobic | ICL2 | T | 687 | - | G.hns1 | R | 38 | G.hns1.02 |
| Van-der-waals | ICL2 | T | 687 | - | G.hns1 | R | 38 | G.hns1.02 |
| Hydrophobic | H8 | S | 857 | 8x56 | G.h4s6 | T | 350 | G.h4s6.03 |
| Hydrophobic | ICL2 | R | 684 | - | G.S3 | V | 217 | G.S3.01 |
| Hydrophobic | TM3 | R | 674 | 3x53 | G.H5 | L | 393 | G.H5.25 |
| Van-der-waals | TM3 | R | 674 | 3x53 | G.H5 | L | 393 | G.H5.25 |
| Polar | ICL2 | V | 686 | - | G.S1 | H | 41 | G.S1.02 |
| Hydrophobic | ICL2 | V | 686 | - | G.S1 | H | 41 | G.S1.02 |
| Van-der-waals | ICL2 | V | 686 | - | G.S1 | H | 41 | G.S1.02 |
| Polar | ICL2 | V | 686 | - | G.hns1 | R | 38 | G.hns1.02 |
| Van-der-waals | ICL2 | V | 686 | - | G.hns1 | R | 38 | G.hns1.02 |
| Hydrophobic | ICL2 | V | 686 | - | G.H5 | I | 383 | G.H5.15 |
| Hydrophobic | TM4 | P | 694 | 4x29 | G.H5 | Y | 391 | G.H5.23 |
| Hydrophobic | H8 | L | 858 | 8x57 | G.hgh4 | D | 323 | G.hgh4.13 |
| Van-der-waals | H8 | L | 858 | 8x57 | G.hgh4 | D | 323 | G.hgh4.13 |
| Hydrophobic | TM6 | F | 779 | 6x33 | G.H5 | R | 385 | G.H5.17 |
| Van-der-waals | TM6 | F | 779 | 6x33 | G.H5 | R | 385 | G.H5.17 |
| Polar | H8 | Q | 852 | 8x51 | G.H5 | L | 394 | G.H5.26 |
| Hydrophobic | H8 | Q | 852 | 8x51 | G.H5 | L | 394 | G.H5.26 |
| Van-der-waals | H8 | Q | 852 | 8x51 | G.H5 | L | 394 | G.H5.26 |
| Hydrophobic | C-term | K | 859 | - | G.hgh4 | E | 322 | G.hgh4.12 |
| Hydrophobic | H8 | K | 855 | 8x54 | G.H5 | R | 385 | G.H5.17 |
| Van-der-waals | H8 | K | 855 | 8x54 | G.H5 | R | 385 | G.H5.17 |
| Polar | C-term | K | 859 | - | G.hgh4 | T | 320 | G.hgh4.10 |
| Hydrophobic | C-term | K | 859 | - | G.hgh4 | T | 320 | G.hgh4.10 |
| Van-der-waals | C-term | K | 859 | - | G.hgh4 | T | 320 | G.hgh4.10 |
| Polar | ICL2 | V | 686 | - | G.H5 | H | 387 | G.H5.19 |
| Hydrophobic | ICL2 | V | 686 | - | G.H5 | H | 387 | G.H5.19 |
| Van-der-waals | ICL2 | V | 686 | - | G.H5 | H | 387 | G.H5.19 |
| Hydrophobic | TM4 | S | 693 | 4x28 | G.H5 | Y | 391 | G.H5.23 |
| Hydrophobic | TM6 | F | 779 | 6x33 | G.H5 | D | 381 | G.H5.13 |
| Van-der-waals | TM6 | F | 779 | 6x33 | G.H5 | D | 381 | G.H5.13 |
| Hydrophobic | TM3 | I | 678 | 3x57 | G.H5 | L | 393 | G.H5.25 |
| Hydrophobic | H8 | L | 858 | 8x57 | G.hgh4 | E | 322 | G.hgh4.12 |
| Van-der-waals | H8 | L | 858 | 8x57 | G.hgh4 | E | 322 | G.hgh4.12 |
| Hydrophobic | TM2 | G | 620 | 2x35 | G.H5 | L | 393 | G.H5.25 |
| Hydrophobic | TM3 | I | 675 | 3x54 | G.H5 | L | 388 | G.H5.20 |
| Hydrophobic | ICL2 | V | 686 | - | G.S1 | T | 40 | G.S1.01 |
| Polar | ICL1 | A | 618 | 12x52 | G.H5 | E | 392 | G.H5.24 |
| Hydrophobic | ICL1 | A | 618 | 12x52 | G.H5 | E | 392 | G.H5.24 |
| Van-der-waals | ICL1 | A | 618 | 12x52 | G.H5 | E | 392 | G.H5.24 |
| Polar | H8 | R | 854 | 8x53 | G.h4s6 | G | 353 | G.h4s6.09 |
| Hydrophobic | H8 | R | 854 | 8x53 | G.h4s6 | G | 353 | G.h4s6.09 |
| Van-der-waals | H8 | R | 854 | 8x53 | G.h4s6 | G | 353 | G.h4s6.09 |
| Hydrophobic | ICL2 | K | 683 | - | G.S3 | V | 217 | G.S3.01 |
| Van-der-waals | ICL2 | K | 683 | - | G.S3 | V | 217 | G.S3.01 |
| Hydrophobic | ICL2 | G | 682 | - | G.H5 | I | 383 | G.H5.15 |
| Polar | TM3 | R | 674 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
| Aromatic | TM3 | R | 674 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
| Hydrophobic | TM3 | R | 674 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
| Van-der-waals | TM3 | R | 674 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
| Hydrophobic | ICL2 | G | 682 | - | G.H5 | R | 380 | G.H5.12 |
| Hydrophobic | TM6 | F | 779 | 6x33 | G.H5 | L | 394 | G.H5.26 |
| Hydrophobic | ICL2 | P | 688 | - | G.H5 | Y | 391 | G.H5.23 |
| Polar | ICL2 | T | 687 | - | G.H5 | H | 387 | G.H5.19 |
| Hydrophobic | ICL2 | T | 687 | - | G.H5 | H | 387 | G.H5.19 |
| Van-der-waals | ICL2 | T | 687 | - | G.H5 | H | 387 | G.H5.19 |
| Hydrophobic | H8 | L | 858 | 8x57 | G.hgh4 | P | 321 | G.hgh4.11 |
| Polar | H8 | R | 854 | 8x53 | G.h4s6 | T | 350 | G.h4s6.03 |
| Van-der-waals | H8 | R | 854 | 8x53 | G.h4s6 | T | 350 | G.h4s6.03 |
| Polar | TM3 | F | 679 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
| Hydrophobic | TM3 | F | 679 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
| Van-der-waals | TM3 | F | 679 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
| Hydrophobic | TM6 | F | 779 | 6x33 | G.H5 | L | 388 | G.H5.20 |
| Polar | ICL2 | P | 688 | - | G.H5 | H | 387 | G.H5.19 |
| Hydrophobic | ICL2 | P | 688 | - | G.H5 | H | 387 | G.H5.19 |
| Van-der-waals | ICL2 | P | 688 | - | G.H5 | H | 387 | G.H5.19 |
| Hydrophobic | H8 | S | 857 | 8x56 | G.H4 | L | 346 | G.H4.16 |
| Hydrophobic | ICL2 | G | 682 | - | G.H5 | Q | 384 | G.H5.16 |
| Hydrophobic | TM3 | I | 675 | 3x54 | G.H5 | L | 393 | G.H5.25 |
| Van-der-waals | TM3 | I | 675 | 3x54 | G.H5 | L | 393 | G.H5.25 |
| Hydrophobic | C-term | K | 859 | - | G.hgh4 | P | 321 | G.hgh4.11 |
| Van-der-waals | C-term | K | 859 | - | G.hgh4 | P | 321 | G.hgh4.11 |
| Hydrophobic | TM3 | F | 679 | 3x58 | G.H5 | L | 388 | G.H5.20 |
| Ionic | ICL1 | R | 617 | 12x51 | G.H5 | E | 392 | G.H5.24 |
| Polar | ICL1 | R | 617 | 12x51 | G.H5 | E | 392 | G.H5.24 |
| Hydrophobic | ICL1 | R | 617 | 12x51 | G.H5 | E | 392 | G.H5.24 |
| Van-der-waals | ICL1 | R | 617 | 12x51 | G.H5 | E | 392 | G.H5.24 |