G13 - H2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 Q 212 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 Q 212 5x68 G.H5 L 367 G.H5.16
Hydrophobic TM6 W 222 6x23 G.h4s6 Q 338 G.h4s6.12
Van-der-waals TM6 W 222 6x23 G.h4s6 Q 338 G.h4s6.12
Van-der-waals TM7 L 291 7x56 G.H5 M 375 G.H5.24
Polar TM3 A 119 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 119 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 119 3x53 G.H5 N 370 G.H5.19
Hydrophobic ICL2 L 124 34x51 G.H5 K 363 G.H5.12
Hydrophobic ICL2 V 128 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM4 T 131 4x38 G.hns1 R 47 G.hns1.03
Van-der-waals TM4 T 131 4x38 G.hns1 R 47 G.hns1.03
Polar TM6 R 228 6x29 G.H5 Q 377 G.H5.26
Hydrophobic TM6 K 231 6x32 G.H5 Q 377 G.H5.26
Van-der-waals TM6 K 231 6x32 G.H5 Q 377 G.H5.26
Hydrophobic TM5 I 216 5x72 G.h4s6 P 341 G.h4s6.20
Hydrophobic ICL2 R 125 34x52 G.S3 V 216 G.S3.01
Van-der-waals ICL2 R 125 34x52 G.S3 V 216 G.S3.01
Hydrophobic TM3 A 119 3x53 G.H5 L 374 G.H5.23
Hydrophobic TM6 K 231 6x32 G.H5 M 375 G.H5.24
Hydrophobic H8 R 293 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 R 293 8x48 G.H5 Q 377 G.H5.26
Hydrophobic TM5 I 216 5x72 G.H5 H 368 G.H5.17
Hydrophobic TM6 W 222 6x23 G.h4s6 P 341 G.h4s6.20
Hydrophobic ICL2 L 124 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 L 124 34x51 G.S3 V 216 G.S3.01
Hydrophobic ICL2 P 123 34x50 G.H5 I 366 G.H5.15
Hydrophobic TM5 I 205 5x61 G.H5 L 371 G.H5.20
Hydrophobic TM7 L 291 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 291 7x56 G.H5 L 376 G.H5.25
Hydrophobic TM7 Y 288 7x53 G.H5 L 376 G.H5.25
Hydrophobic TM3 V 120 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 120 3x54 G.H5 L 374 G.H5.23
Hydrophobic TM6 T 235 6x36 G.H5 M 375 G.H5.24
Hydrophobic TM3 V 120 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 120 3x54 G.H5 L 367 G.H5.16
Polar TM5 Q 212 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 Q 212 5x68 G.H5 D 364 G.H5.13
Polar ICL2 R 125 34x52 G.s2s3 K 214 G.s2s3.01
Hydrophobic ICL2 R 125 34x52 G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 R 125 34x52 G.s2s3 K 214 G.s2s3.01
Hydrophobic ICL2 P 123 34x50 G.H5 L 367 G.H5.16
Hydrophobic TM5 V 208 5x64 G.H5 L 367 G.H5.16
Hydrophobic ICL2 L 124 34x51 G.S1 V 49 G.S1.02
Hydrophobic ICL3 I 219 - G.S6 Y 343 G.S6.02
Polar H8 R 293 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 R 293 8x48 G.H5 L 376 G.H5.25
Hydrophobic ICL2 P 123 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 P 123 34x50 G.H5 K 363 G.H5.12
Polar ICL3 I 219 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 I 219 - G.H4 R 331 G.H4.16
Hydrophobic TM3 V 120 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 V 120 3x54 G.H5 L 371 G.H5.20
Hydrophobic ICL2 P 127 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 L 124 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 124 34x51 G.H5 I 366 G.H5.15
Hydrophobic TM6 W 222 6x23 G.h4s6 K 340 G.h4s6.19
Van-der-waals TM6 W 222 6x23 G.h4s6 K 340 G.h4s6.19
Polar H8 N 292 8x47 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 L 124 34x51 G.S3 F 218 G.S3.03
Hydrophobic TM5 A 209 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 A 209 5x65 G.H5 L 371 G.H5.20
Aromatic TM6 W 222 6x23 G.h4s6 R 334 G.h4s6.08
Hydrophobic TM6 R 228 6x29 G.H5 M 375 G.H5.24
Van-der-waals TM6 R 228 6x29 G.H5 M 375 G.H5.24
Polar TM3 R 116 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 116 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 116 3x50 G.H5 L 374 G.H5.23
Polar ICL2 P 127 34x54 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 P 127 34x54 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 P 127 34x54 G.hns1 R 47 G.hns1.03
Polar TM6 R 228 6x29 G.H5 H 368 G.H5.17
Hydrophobic H8 F 295 8x50 G.H5 L 376 G.H5.25
Polar H8 N 292 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 N 292 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 N 292 8x47 G.H5 L 376 G.H5.25
Polar TM6 R 228 6x29 G.h4s6 Q 339 G.h4s6.13
Hydrophobic TM6 R 228 6x29 G.h4s6 Q 339 G.h4s6.13
Van-der-waals TM6 R 228 6x29 G.h4s6 Q 339 G.h4s6.13
Hydrophobic TM6 W 222 6x23 G.h4s6 Q 339 G.h4s6.13
Van-der-waals TM6 W 222 6x23 G.h4s6 Q 339 G.h4s6.13
Hydrophobic TM6 A 232 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 232 6x33 G.H5 M 375 G.H5.24
Polar TM5 Q 212 5x68 G.H5 H 368 G.H5.17
Hydrophobic TM5 Q 212 5x68 G.H5 H 368 G.H5.17
Van-der-waals TM5 Q 212 5x68 G.H5 H 368 G.H5.17
Ionic TM5 R 215 5x71 G.H5 D 364 G.H5.13
Van-der-waals ICL2 P 123 34x50 G.H5 N 370 G.H5.19
Hydrophobic TM5 Q 212 5x68 G.H5 L 371 G.H5.20
Van-der-waals TM5 Q 212 5x68 G.H5 L 371 G.H5.20