G12 - Y5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 143 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 I 147 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 I 147 - G.H5 F 363 G.H5.08
Hydrophobic ECL2 V 199 45x51 G.HN S 2 G.HN.02
Van-der-waals ECL2 V 199 45x51 G.HN S 2 G.HN.02
Hydrophobic N-term P 28 - G.HN M 1 G.HN.01
Van-der-waals N-term P 28 - G.HN M 1 G.HN.01
Polar TM3 M 113 3x24 G.HN R 6 G.HN.06
Hydrophobic TM3 M 113 3x24 G.HN R 6 G.HN.06
Van-der-waals TM3 M 113 3x24 G.HN R 6 G.HN.06
Hydrophobic ICL2 P 146 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 146 - G.H5 K 367 G.H5.12
Hydrophobic ICL3 M 254 - G.H4 Q 328 G.H4.08
Van-der-waals ICL3 M 254 - G.H4 Q 328 G.H4.08
Polar TM3 I 116 3x27 G.HN L 8 G.HN.08
Hydrophobic TM6 R 362 6x29 G.H5 K 376 G.H5.21
Hydrophobic ICL3 M 254 - G.H4 R 329 G.H4.09
Polar TM3 M 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 M 142 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 M 142 3x53 G.H5 N 374 G.H5.19
Polar TM4 H 178 4x65 G.HN R 6 G.HN.06
Aromatic TM4 H 178 4x65 G.HN R 6 G.HN.06
Hydrophobic TM4 H 178 4x65 G.HN R 6 G.HN.06
Van-der-waals TM4 H 178 4x65 G.HN R 6 G.HN.06
Polar TM6 R 358 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 R 358 6x25 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 358 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM2 T 98 2x60 G.HN V 5 G.HN.05
Ionic ICL3 R 351 - G.H4 D 336 G.H4.16
Polar ICL3 R 351 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 R 351 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 R 351 - G.H4 D 336 G.H4.16
Hydrophobic ICL2 I 147 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 I 147 - G.S1 V 58 G.S1.02
Hydrophobic TM5 I 238 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM2 T 98 2x60 G.HN V 4 G.HN.04
Polar ICL2 N 150 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 150 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 150 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 143 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM7 Y 425 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 425 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM7 L 428 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 428 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM3 M 117 3x28 G.HN R 6 G.HN.06
Van-der-waals TM3 M 117 3x28 G.HN R 6 G.HN.06
Hydrophobic ICL2 I 147 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 I 147 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 I 147 - G.H5 I 370 G.H5.15
Hydrophobic TM3 P 118 3x29 G.HN V 4 G.HN.04
Van-der-waals TM3 P 118 3x29 G.HN V 4 G.HN.04
Hydrophobic ICL2 S 148 - G.S3 I 221 G.S3.01
Hydrophobic TM6 S 365 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 365 6x32 G.H5 M 379 G.H5.24
Polar ICL3 M 254 - G.S6 H 348 G.S6.03
Polar TM6 R 362 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 362 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 362 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 M 254 - G.S6 F 350 G.S6.05
Van-der-waals ICL3 M 254 - G.S6 F 350 G.S6.05
Polar TM4 N 154 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 N 154 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 N 154 4x40 G.HN R 52 G.HN.52
Hydrophobic ICL2 P 146 - G.H5 L 371 G.H5.16
Polar TM3 M 113 3x24 G.HN T 7 G.HN.07
Hydrophobic TM3 M 113 3x24 G.HN T 7 G.HN.07
Van-der-waals TM3 M 113 3x24 G.HN T 7 G.HN.07
Hydrophobic ICL3 S 355 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 S 355 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 I 359 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM3 Q 121 3x32 G.HN V 5 G.HN.05
Van-der-waals TM3 Q 121 3x32 G.HN V 5 G.HN.05
Hydrophobic ICL2 P 146 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 146 - G.H5 I 370 G.H5.15
Polar TM6 S 365 6x32 G.H5 Q 381 G.H5.26
Polar TM6 R 369 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 369 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 369 6x36 G.H5 M 379 G.H5.24
Polar TM4 L 174 4x61 G.HN R 6 G.HN.06
Hydrophobic TM4 L 174 4x61 G.HN R 6 G.HN.06
Van-der-waals TM4 L 174 4x61 G.HN R 6 G.HN.06
Hydrophobic ECL1 W 107 23x50 G.HN V 4 G.HN.04
Hydrophobic TM4 T 152 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 T 152 4x38 G.HN R 52 G.HN.52
Polar H8 N 430 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 N 430 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 N 430 8x48 G.H5 L 380 G.H5.25
Polar TM3 P 118 3x29 G.HN R 6 G.HN.06
Hydrophobic TM3 P 118 3x29 G.HN R 6 G.HN.06
Van-der-waals TM3 P 118 3x29 G.HN R 6 G.HN.06
Hydrophobic TM4 H 178 4x65 G.HN G 3 G.HN.03
Van-der-waals TM4 H 178 4x65 G.HN G 3 G.HN.03
Hydrophobic TM7 F 403 7x30 G.HN M 1 G.HN.01
Van-der-waals TM7 F 403 7x30 G.HN M 1 G.HN.01
Polar TM3 H 115 3x26 G.HN R 6 G.HN.06
Hydrophobic TM3 H 115 3x26 G.HN R 6 G.HN.06
Van-der-waals TM3 H 115 3x26 G.HN R 6 G.HN.06
Hydrophobic ICL2 I 147 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 147 - G.S3 I 221 G.S3.01
Hydrophobic TM3 I 143 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 143 3x54 G.H5 I 378 G.H5.23
Hydrophobic H8 N 430 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 430 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 I 255 - G.S6 H 348 G.S6.03
Polar ICL2 P 146 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 146 - G.H5 N 374 G.H5.19
Van-der-waals TM3 M 113 3x24 G.HN V 5 G.HN.05
Polar ECL2 C 198 45x50 G.HN V 4 G.HN.04
Hydrophobic ECL2 C 198 45x50 G.HN V 4 G.HN.04
Hydrophobic TM6 V 366 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 366 6x33 G.H5 M 379 G.H5.24
Polar TM3 M 117 3x28 G.HN V 5 G.HN.05
Hydrophobic TM3 M 117 3x28 G.HN V 5 G.HN.05
Van-der-waals TM3 M 117 3x28 G.HN V 5 G.HN.05
Hydrophobic TM3 M 142 3x53 G.H5 D 377 G.H5.22
Polar TM3 C 114 3x25 G.HN R 6 G.HN.06
Hydrophobic TM3 C 114 3x25 G.HN R 6 G.HN.06
Van-der-waals TM3 C 114 3x25 G.HN R 6 G.HN.06
Hydrophobic TM2 F 97 2x59 G.HN V 5 G.HN.05
Van-der-waals TM2 F 97 2x59 G.HN V 5 G.HN.05
Hydrophobic TM3 F 119 3x30 G.HN R 6 G.HN.06
Van-der-waals TM3 F 119 3x30 G.HN R 6 G.HN.06
Hydrophobic TM7 L 424 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 424 7x52 G.H5 L 380 G.H5.25
Polar TM3 I 116 3x27 G.HN R 6 G.HN.06
Hydrophobic TM3 I 116 3x27 G.HN R 6 G.HN.06
Van-der-waals TM3 I 116 3x27 G.HN R 6 G.HN.06
Polar TM4 C 171 4x57 G.HN R 6 G.HN.06
Van-der-waals TM4 C 171 4x57 G.HN R 6 G.HN.06
Van-der-waals TM3 I 116 3x27 G.HN S 9 G.HN.09
Polar TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 M 117 3x28 G.HN T 7 G.HN.07
Van-der-waals TM3 M 117 3x28 G.HN T 7 G.HN.07
Polar H8 N 429 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 429 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 429 8x47 G.H5 L 380 G.H5.25
Polar TM6 R 369 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 369 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 112 3x23 G.HN T 7 G.HN.07
Van-der-waals TM3 V 112 3x23 G.HN T 7 G.HN.07
Polar ECL2 C 198 45x50 G.HN G 3 G.HN.03
Hydrophobic ECL2 C 198 45x50 G.HN G 3 G.HN.03
Van-der-waals ECL2 C 198 45x50 G.HN G 3 G.HN.03
Polar TM3 P 118 3x29 G.HN V 5 G.HN.05
Hydrophobic TM3 P 118 3x29 G.HN V 5 G.HN.05
Van-der-waals TM3 P 118 3x29 G.HN V 5 G.HN.05
Van-der-waals ECL2 E 200 45x52 G.HN G 3 G.HN.03
Polar ICL2 N 149 - G.H5 N 374 G.H5.19
Hydrophobic TM5 V 234 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 112 3x23 G.HN R 6 G.HN.06
Polar ECL2 E 200 45x52 G.HN S 2 G.HN.02
Hydrophobic ECL2 E 200 45x52 G.HN S 2 G.HN.02
Van-der-waals ECL2 E 200 45x52 G.HN S 2 G.HN.02
Polar ECL2 V 199 45x51 G.HN G 3 G.HN.03
Hydrophobic ECL2 V 199 45x51 G.HN G 3 G.HN.03
Van-der-waals ECL2 V 199 45x51 G.HN G 3 G.HN.03
Hydrophobic TM4 P 175 4x62 G.HN R 6 G.HN.06
Van-der-waals TM4 P 175 4x62 G.HN R 6 G.HN.06
Hydrophobic N-term W 30 - G.HN M 1 G.HN.01
Van-der-waals N-term W 30 - G.HN M 1 G.HN.01
Polar H8 N 429 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM3 M 142 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 M 142 3x53 G.H5 I 378 G.H5.23
Polar TM4 H 178 4x65 G.HN S 2 G.HN.02
Polar TM3 I 116 3x27 G.HN T 7 G.HN.07
Hydrophobic TM3 I 116 3x27 G.HN T 7 G.HN.07
Van-der-waals TM3 I 116 3x27 G.HN T 7 G.HN.07
Hydrophobic ECL1 W 107 23x50 G.HN V 5 G.HN.05
Van-der-waals ECL1 W 107 23x50 G.HN V 5 G.HN.05
Ionic TM5 K 245 5x72 G.H5 D 368 G.H5.13
Polar TM5 K 245 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 245 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 245 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM3 M 113 3x24 G.HN L 8 G.HN.08
Van-der-waals TM3 R 139 3x50 G.H5 L 380 G.H5.25
Hydrophobic ICL3 I 255 - G.H5 F 361 G.H5.06
Hydrophobic TM2 S 101 2x63 G.HN V 4 G.HN.04
Van-der-waals TM2 S 101 2x63 G.HN V 4 G.HN.04
Polar TM4 H 178 4x65 G.HN V 4 G.HN.04