Gt1 - OPN1SW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 I 69 2x42 G.H5 D 346 G.H5.22
Hydrophobic ICL2 G 138 34x52 G.H5 I 339 G.H5.15
Hydrophobic TM5 V 227 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 V 227 5x68 G.H5 I 340 G.H5.16
Hydrophobic TM6 R 246 6x35 G.H5 F 350 G.H5.26
Van-der-waals TM6 R 246 6x35 G.H5 F 350 G.H5.26
Hydrophobic H8 F 307 8x50 G.H5 G 348 G.H5.24
Van-der-waals H8 F 307 8x50 G.H5 G 348 G.H5.24
Hydrophobic ICL2 P 136 34x50 G.H5 L 344 G.H5.20
Hydrophobic TM5 Q 230 5x71 G.H5 D 337 G.H5.13
Hydrophobic TM6 T 237 6x26 G.S6 Y 316 G.S6.02
Hydrophobic ICL2 P 136 34x50 G.H5 C 347 G.H5.23
Aromatic H8 Q 308 8x51 G.H5 F 350 G.H5.26
Hydrophobic H8 Q 308 8x51 G.H5 F 350 G.H5.26
Van-der-waals H8 Q 308 8x51 G.H5 F 350 G.H5.26
Hydrophobic TM5 A 223 5x64 G.H5 L 349 G.H5.25
Polar TM6 Q 238 6x27 G.h4s6 E 314 G.h4s6.12
Hydrophobic ICL2 P 136 34x50 G.H5 N 343 G.H5.19
Polar TM3 V 132 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM3 V 132 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 V 132 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM2 I 69 2x42 G.H5 C 347 G.H5.23
Hydrophobic TM3 K 135 3x56 G.H5 C 347 G.H5.23
Hydrophobic TM5 Q 230 5x71 G.H5 T 336 G.H5.12
Polar TM6 S 234 6x23 G.H5 D 333 G.H5.09
Hydrophobic TM6 S 234 6x23 G.H5 D 333 G.H5.09
Van-der-waals TM6 S 234 6x23 G.H5 D 333 G.H5.09
Hydrophobic TM6 V 250 6x39 G.H5 L 349 G.H5.25
Van-der-waals TM6 V 250 6x39 G.H5 L 349 G.H5.25
Polar TM6 K 239 6x28 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 K 239 6x28 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 K 239 6x28 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM4 S 144 4x39 G.HN E 24 G.HN.52
Van-der-waals TM4 S 144 4x39 G.HN E 24 G.HN.52
Polar TM6 T 237 6x26 G.H5 K 341 G.H5.17
Van-der-waals TM6 T 237 6x26 G.H5 K 341 G.H5.17
Hydrophobic TM5 Q 230 5x71 G.H5 I 340 G.H5.16
Van-der-waals TM5 Q 230 5x71 G.H5 I 340 G.H5.16
Hydrophobic TM6 S 234 6x23 G.H5 D 337 G.H5.13
Van-der-waals TM6 S 234 6x23 G.H5 D 337 G.H5.13
Hydrophobic TM5 V 227 5x68 G.H5 L 344 G.H5.20
Van-der-waals TM5 V 227 5x68 G.H5 L 344 G.H5.20
Ionic TM6 T 236 6x25 G.S6 H 318 G.S6.04
Polar TM6 T 237 6x26 G.H5 D 337 G.H5.13
Polar TM6 A 240 6x29 G.H5 K 341 G.H5.17
Hydrophobic TM6 A 240 6x29 G.H5 K 341 G.H5.17
Van-der-waals TM6 A 240 6x29 G.H5 K 341 G.H5.17
Hydrophobic TM6 M 247 6x36 G.H5 L 349 G.H5.25
Polar H8 A 309 8x52 G.H5 K 345 G.H5.21
Polar ICL2 F 142 34x56 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 F 142 34x56 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 F 142 34x56 G.hns1 R 28 G.hns1.03
Polar TM4 S 144 4x39 G.HN A 23 G.HN.51
Hydrophobic TM4 S 144 4x39 G.HN A 23 G.HN.51
Van-der-waals TM4 S 144 4x39 G.HN A 23 G.HN.51
Hydrophobic TM6 M 247 6x36 G.H5 L 344 G.H5.20
Hydrophobic TM6 S 254 6x43 G.H5 L 349 G.H5.25
Hydrophobic TM3 V 132 3x53 G.H5 L 349 G.H5.25
Van-der-waals TM3 V 132 3x53 G.H5 L 349 G.H5.25
Polar TM3 K 135 3x56 G.H5 N 343 G.H5.19
Hydrophobic TM3 K 135 3x56 G.H5 N 343 G.H5.19
Polar TM6 T 237 6x26 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 T 237 6x26 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 T 237 6x26 G.h4s6 E 314 G.h4s6.12
Polar TM6 K 239 6x28 G.H5 K 341 G.H5.17
Hydrophobic TM6 K 239 6x28 G.H5 K 341 G.H5.17
Van-der-waals TM6 K 239 6x28 G.H5 K 341 G.H5.17
Polar TM6 A 240 6x29 G.H5 D 337 G.H5.13
Hydrophobic TM6 A 240 6x29 G.H5 D 337 G.H5.13
Van-der-waals TM6 A 240 6x29 G.H5 D 337 G.H5.13
Hydrophobic TM6 S 234 6x23 G.S6 Y 316 G.S6.02
Hydrophobic TM6 E 243 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 E 243 6x32 G.H5 L 344 G.H5.20
Hydrophobic ICL2 P 136 34x50 G.H5 L 349 G.H5.25
Hydrophobic TM4 S 144 4x39 G.hns1 A 27 G.hns1.02
Van-der-waals TM4 S 144 4x39 G.hns1 A 27 G.hns1.02