Gi3 - FP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 141 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 141 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 M 247 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 247 6x33 G.H5 L 353 G.H5.25
Polar TM6 H 243 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 T 145 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 T 145 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM4 K 150 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 K 150 4x40 G.HN R 24 G.HN.48
Hydrophobic ICL2 S 144 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM2 K 63 2x36 G.H5 E 350 G.H5.22
Van-der-waals TM2 K 63 2x36 G.H5 E 350 G.H5.22
Polar TM6 R 241 6x27 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 R 241 6x27 G.h4s6 K 314 G.h4s6.08
Polar TM6 H 237 6x23 G.S6 T 321 G.S6.03
Van-der-waals TM6 H 237 6x23 G.S6 T 321 G.S6.03
Polar TM3 G 136 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 136 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 136 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 140 34x50 G.H5 I 343 G.H5.15
Aromatic TM6 H 237 6x23 G.S6 H 322 G.S6.04
Hydrophobic TM6 H 237 6x23 G.S6 H 322 G.S6.04
Polar TM6 Q 239 6x25 G.H4 E 308 G.H4.16
Hydrophobic TM6 Q 239 6x25 G.H4 E 308 G.H4.16
Van-der-waals TM6 Q 239 6x25 G.H4 E 308 G.H4.16
Polar TM6 Q 239 6x25 G.h4s6 N 311 G.h4s6.02
Polar TM6 Q 250 6x36 G.H5 G 352 G.H5.24
Polar H8 R 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 R 308 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 R 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 V 230 5x66 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 230 5x66 G.H5 D 341 G.H5.13
Hydrophobic TM6 Q 250 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 Q 250 6x36 G.H5 L 353 G.H5.25
Polar ICL2 P 140 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 140 34x50 G.H5 N 347 G.H5.19
Ionic TM6 R 238 6x24 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 238 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 238 6x24 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 238 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 251 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 141 34x51 G.H5 I 343 G.H5.15
Polar TM2 F 66 2x39 G.H5 E 350 G.H5.22
Hydrophobic TM2 F 66 2x39 G.H5 E 350 G.H5.22
Van-der-waals TM2 F 66 2x39 G.H5 E 350 G.H5.22
Hydrophobic TM2 F 66 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 F 66 2x39 G.H5 G 352 G.H5.24
Polar TM4 T 148 4x38 G.HN R 24 G.HN.48
Hydrophobic TM4 T 148 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 T 148 4x38 G.HN R 24 G.HN.48
Polar ICL3 S 234 - G.H5 D 341 G.H5.13
Hydrophobic TM5 L 227 5x63 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 227 5x63 G.H5 L 348 G.H5.20
Ionic TM2 K 61 2x34 G.h3s5 E 261 G.h3s5.02
Hydrophobic TM3 E 132 3x49 G.H5 C 351 G.H5.23
Polar TM6 R 238 6x24 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 238 6x24 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 238 6x24 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 I 141 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 141 34x51 G.S3 L 194 G.S3.01
Van-der-waals TM6 R 238 6x24 G.S6 I 319 G.S6.01
Polar TM6 Q 239 6x25 G.S6 I 319 G.S6.01
Hydrophobic TM6 Q 239 6x25 G.S6 I 319 G.S6.01
Van-der-waals TM6 Q 239 6x25 G.S6 I 319 G.S6.01
Hydrophobic TM4 T 148 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 148 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 G 240 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 H 143 34x53 G.H5 C 351 G.H5.23
Van-der-waals TM6 Q 239 6x25 G.h4s6 E 318 G.h4s6.12
Ionic TM6 R 241 6x27 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 241 6x27 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 241 6x27 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 241 6x27 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 G 240 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 R 133 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 133 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 247 6x33 G.H5 Y 354 G.H5.26
Polar H8 R 308 8x47 G.H5 Y 354 G.H5.26
Van-der-waals H8 R 308 8x47 G.H5 Y 354 G.H5.26
Polar TM6 H 243 6x29 G.H5 Y 354 G.H5.26
Aromatic TM6 H 243 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 H 243 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 H 243 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 M 247 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 M 247 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 140 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM2 F 66 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 K 63 2x36 G.hns1 A 31 G.hns1.02
Van-der-waals TM2 K 63 2x36 G.hns1 A 31 G.hns1.02
Polar ICL2 S 144 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 144 34x54 G.hns1 A 31 G.hns1.02
Polar ICL2 H 143 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 H 143 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 H 143 34x53 G.H5 N 347 G.H5.19
Van-der-waals TM6 H 237 6x23 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 140 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 140 34x50 G.H5 I 344 G.H5.16
Ionic TM6 R 238 6x24 G.H5 D 341 G.H5.13
Polar TM6 R 238 6x24 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 238 6x24 G.H5 D 341 G.H5.13
Hydrophobic TM3 V 137 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 137 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 Q 239 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 I 141 34x51 G.s2s3 D 193 G.s2s3.02
Polar TM6 Q 239 6x25 G.H4 D 309 G.H4.17