G12 - TPRA1 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 70.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 25.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ECL3 K 289 - G.H3 L 285 G.H3.17
Van-der-waals ECL3 K 289 - G.H3 L 285 G.H3.17
Polar TM7 Q 297 7x38 G.H2 R 232 G.H2.01
Hydrophobic TM7 Q 297 7x38 G.H2 R 232 G.H2.01
Van-der-waals TM7 Q 297 7x38 G.H2 R 232 G.H2.01
Polar TM3 S 144 3x53 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 S 144 3x53 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 S 144 3x53 G.hns1 R 55 G.hns1.02
Polar TM3 E 143 3x52 G.H5 Q 381 G.H5.26
Hydrophobic TM3 E 143 3x52 G.H5 Q 381 G.H5.26
Van-der-waals TM3 E 143 3x52 G.H5 Q 381 G.H5.26
Ionic TM7 D 305 7x46 G.hfs2 K 209 G.hfs2.06
Polar TM7 D 305 7x46 G.hfs2 K 209 G.hfs2.06
Hydrophobic H8 F 338 8x55 H.HD E 172 H.HD.12
Hydrophobic TM7 C 296 7x37 G.H2 R 232 G.H2.01
Hydrophobic H8 T 336 8x53 H.HA V 107 H.HA.21
Hydrophobic TM7 L 308 7x49 H.HB F 134 H.HB.12
Van-der-waals TM7 L 308 7x49 H.HB F 134 H.HB.12
Polar TM3 H 141 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 H 141 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 H 141 3x50 G.H5 M 379 G.H5.24
Hydrophobic H8 T 336 8x53 H.hdhe F 173 H.hdhe.01
Polar TM7 P 311 7x52 H.HB E 135 H.HB.13
Hydrophobic TM7 P 311 7x52 H.HB E 135 H.HB.13
Van-der-waals TM7 P 311 7x52 H.HB E 135 H.HB.13
Hydrophobic ECL3 F 292 - G.h2s4 F 242 G.h2s4.01
Hydrophobic H8 S 335 8x52 H.hdhe F 173 H.hdhe.01
Van-der-waals H8 S 335 8x52 H.hdhe F 173 H.hdhe.01
Hydrophobic H8 F 338 8x55 H.HA A 111 H.HA.25
Polar TM3 G 140 3x49 G.H5 Q 381 G.H5.26
Hydrophobic TM3 G 140 3x49 G.H5 Q 381 G.H5.26
Van-der-waals TM3 G 140 3x49 G.H5 Q 381 G.H5.26
Polar TM7 C 296 7x37 G.H2 Q 236 G.H2.05
Hydrophobic TM7 C 296 7x37 G.H2 Q 236 G.H2.05
Van-der-waals TM7 C 296 7x37 G.H2 Q 236 G.H2.05
Polar H8 S 335 8x52 H.hdhe Q 174 H.hdhe.02
Hydrophobic H8 S 335 8x52 H.hdhe Q 174 H.hdhe.02
Van-der-waals H8 S 335 8x52 H.hdhe Q 174 H.hdhe.02
Polar TM7 D 299 7x40 G.H2 S 233 G.H2.02
Hydrophobic TM7 D 299 7x40 G.H2 S 233 G.H2.02
Van-der-waals TM7 D 299 7x40 G.H2 S 233 G.H2.02
Hydrophobic ECL3 L 291 - G.H2 F 239 G.H2.08
Van-der-waals ECL3 L 291 - G.H2 F 239 G.H2.08
Hydrophobic H8 T 336 8x53 H.HA A 111 H.HA.25
Van-der-waals H8 T 336 8x53 H.HA A 111 H.HA.25
Hydrophobic TM7 Y 294 7x35 G.H3 I 276 G.H3.08
Hydrophobic ECL3 F 292 - G.H3 I 280 G.H3.12
Van-der-waals ECL3 F 292 - G.H3 I 280 G.H3.12
Polar H8 Y 333 8x50 H.HA K 114 H.HA.28
Van-der-waals H8 Y 333 8x50 H.HA K 114 H.HA.28
Ionic TM7 E 303 7x44 G.s4h3 R 265 G.s4h3.12
Van-der-waals TM3 K 145 3x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 G 140 3x49 G.H5 L 380 G.H5.25
Van-der-waals TM3 G 140 3x49 G.H5 L 380 G.H5.25
Hydrophobic ECL3 F 292 - G.H2 R 235 G.H2.04
Van-der-waals ECL3 F 292 - G.H2 R 235 G.H2.04
Polar TM3 S 146 3x55 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 S 146 3x55 G.hns1 R 55 G.hns1.02
Polar TM7 D 299 7x40 G.H2 R 232 G.H2.01
Hydrophobic TM7 D 299 7x40 G.H2 R 232 G.H2.01
Van-der-waals TM7 D 299 7x40 G.H2 R 232 G.H2.01
Aromatic ECL3 F 292 - G.H2 W 238 G.H2.07
Hydrophobic ECL3 F 292 - G.H2 W 238 G.H2.07
Van-der-waals ECL3 F 292 - G.H2 W 238 G.H2.07
Hydrophobic ICL1 S 76 - G.h2s4 G 244 G.h2s4.03
Hydrophobic TM3 L 142 3x51 G.H5 Q 381 G.H5.26
Van-der-waals TM3 L 142 3x51 G.H5 Q 381 G.H5.26
Hydrophobic H8 F 338 8x55 H.HA L 115 H.HA.29
Van-der-waals H8 F 338 8x55 H.HA L 115 H.HA.29
Hydrophobic ECL3 F 292 - G.H3 I 276 G.H3.08
Van-der-waals ECL3 F 292 - G.H3 I 276 G.H3.08
Polar TM7 Y 294 7x35 G.H2 R 235 G.H2.04
Aromatic TM7 Y 294 7x35 G.H2 R 235 G.H2.04
Hydrophobic TM7 Y 294 7x35 G.H2 R 235 G.H2.04
Van-der-waals TM7 Y 294 7x35 G.H2 R 235 G.H2.04
Polar TM7 Y 294 7x35 G.H2 R 232 G.H2.01
Hydrophobic TM7 Y 294 7x35 G.H2 R 232 G.H2.01
Van-der-waals TM7 Y 294 7x35 G.H2 R 232 G.H2.01
Ionic ECL3 K 289 - G.h2s4 D 243 G.h2s4.02
Polar ECL3 K 289 - G.h2s4 D 243 G.h2s4.02
Van-der-waals ECL3 K 289 - G.h2s4 D 243 G.h2s4.02
Hydrophobic TM1 I 74 1x60 G.h2s4 D 243 G.h2s4.02
Van-der-waals TM1 I 74 1x60 G.h2s4 D 243 G.h2s4.02
Polar TM7 Y 294 7x35 G.H3 E 272 G.H3.04
Hydrophobic TM7 Y 294 7x35 G.H3 E 272 G.H3.04
Van-der-waals TM7 Y 294 7x35 G.H3 E 272 G.H3.04
Hydrophobic H8 F 338 8x55 H.HA K 114 H.HA.28
Van-der-waals H8 F 338 8x55 H.HA K 114 H.HA.28
Polar H8 T 336 8x53 H.HA D 110 H.HA.24
Hydrophobic H8 T 336 8x53 H.HA D 110 H.HA.24
Van-der-waals H8 T 336 8x53 H.HA D 110 H.HA.24
Hydrophobic TM3 K 145 3x54 G.HN R 51 G.HN.51
Van-der-waals TM3 K 145 3x54 G.HN R 51 G.HN.51
Hydrophobic TM3 H 141 3x50 G.H5 Q 381 G.H5.26
Van-der-waals TM3 H 141 3x50 G.H5 Q 381 G.H5.26
Polar H8 S 334 8x51 G.s4h3 R 265 G.s4h3.12
Hydrophobic H8 S 334 8x51 G.s4h3 R 265 G.s4h3.12
Van-der-waals H8 S 334 8x51 G.s4h3 R 265 G.s4h3.12
Polar H8 Y 333 8x50 H.HA R 106 H.HA.20
Hydrophobic H8 F 338 8x55 H.hdhe F 173 H.hdhe.01
Polar H8 T 336 8x53 H.HA K 114 H.HA.28
Hydrophobic H8 T 336 8x53 H.HA K 114 H.HA.28
Van-der-waals H8 T 336 8x53 H.HA K 114 H.HA.28
Hydrophobic TM7 L 308 7x49 H.HB E 135 H.HB.13
Polar ICL1 T 75 - G.h2s4 D 243 G.h2s4.02
Hydrophobic ICL1 T 75 - G.h2s4 D 243 G.h2s4.02
Van-der-waals ICL1 T 75 - G.h2s4 D 243 G.h2s4.02
Polar H8 Q 337 8x54 G.s4h3 R 265 G.s4h3.12
Hydrophobic H8 Q 337 8x54 G.s4h3 R 265 G.s4h3.12
Van-der-waals H8 Q 337 8x54 G.s4h3 R 265 G.s4h3.12
Hydrophobic TM7 D 299 7x40 G.s4h3 E 263 G.s4h3.10
Van-der-waals TM7 D 299 7x40 G.s4h3 E 263 G.s4h3.10
Hydrophobic H8 Y 333 8x50 H.HB M 132 H.HB.10
Van-der-waals H8 Y 333 8x50 H.HB M 132 H.HB.10
Hydrophobic TM7 L 308 7x49 H.HA R 106 H.HA.20
Van-der-waals TM7 L 308 7x49 H.HA R 106 H.HA.20
Polar ECL3 I 290 - G.H3 N 283 G.H3.15
Van-der-waals ECL3 I 290 - G.H3 N 283 G.H3.15
Hydrophobic ECL3 S 293 - G.H3 T 279 G.H3.11
Hydrophobic ECL3 F 292 - G.H3 T 279 G.H3.11
Van-der-waals ECL3 F 292 - G.H3 T 279 G.H3.11
Polar TM3 H 141 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 H 141 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 H 141 3x50 G.H5 L 380 G.H5.25
Hydrophobic H8 Y 333 8x50 H.HA D 110 H.HA.24
Van-der-waals H8 Y 333 8x50 H.HA D 110 H.HA.24
Hydrophobic H8 S 335 8x52 H.HA V 107 H.HA.21
Van-der-waals H8 S 335 8x52 H.HA V 107 H.HA.21