Go - TPRA1 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 69.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ECL3 G 282 - G.S3 L 195 G.S3.01
Van-der-waals ECL3 G 282 - G.S3 L 195 G.S3.01
Polar TM7 Y 294 7x35 G.H2 C 215 G.H2.10
Hydrophobic TM7 Y 294 7x35 G.H2 C 215 G.H2.10
Van-der-waals TM7 Y 294 7x35 G.H2 C 215 G.H2.10
Hydrophobic ECL3 F 292 - G.h2s4 F 216 G.h2s4.01
Van-der-waals ECL3 F 292 - G.h2s4 F 216 G.h2s4.01
Hydrophobic TM5 V 208 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 V 208 5x61 G.H5 L 353 G.H5.25
Polar ECL3 I 290 - G.S1 K 35 G.S1.03
Hydrophobic ECL3 I 290 - G.S1 K 35 G.S1.03
Van-der-waals ECL3 I 290 - G.S1 K 35 G.S1.03
Hydrophobic ECL3 F 292 - G.H2 H 214 G.H2.09
Hydrophobic ICL1 F 80 - G.H5 T 340 G.H5.12
Van-der-waals ICL1 F 80 - G.H5 T 340 G.H5.12
Hydrophobic TM7 L 308 7x49 G.hfs2 V 180 G.hfs2.03
Van-der-waals TM7 L 308 7x49 G.hfs2 V 180 G.hfs2.03
Hydrophobic ECL3 F 292 - G.S1 L 37 G.S1.05
Van-der-waals ECL3 F 292 - G.S1 L 37 G.S1.05
Ionic TM7 D 305 7x46 G.hfs2 K 181 G.hfs2.04
Polar TM7 D 305 7x46 G.hfs2 K 181 G.hfs2.04
Hydrophobic TM7 D 305 7x46 G.hfs2 K 181 G.hfs2.04
Van-der-waals TM7 D 305 7x46 G.hfs2 K 181 G.hfs2.04
Hydrophobic ECL3 I 290 - G.h2s4 D 218 G.h2s4.03
Van-der-waals ECL3 I 290 - G.h2s4 D 218 G.h2s4.03
Hydrophobic ICL3 V 209 - G.H5 L 353 G.H5.25
Van-der-waals ICL3 V 209 - G.H5 L 353 G.H5.25
Hydrophobic ECL3 G 285 - G.HN I 28 G.HN.52
Van-der-waals ECL3 G 285 - G.HN I 28 G.HN.52
Polar TM7 Y 294 7x35 G.s3h2 G 203 G.s3h2.01
Hydrophobic TM7 Y 294 7x35 G.s3h2 G 203 G.s3h2.01
Van-der-waals TM7 Y 294 7x35 G.s3h2 G 203 G.s3h2.01
Polar TM7 K 295 7x36 G.H2 K 211 G.H2.06
Hydrophobic TM7 K 295 7x36 G.H2 K 211 G.H2.06
Van-der-waals TM7 K 295 7x36 G.H2 K 211 G.H2.06
Polar ECL3 E 287 - G.S1 D 33 G.S1.01
Hydrophobic ECL3 E 287 - G.S1 D 33 G.S1.01
Van-der-waals ECL3 E 287 - G.S1 D 33 G.S1.01
Polar ECL3 F 284 - G.hns1 K 32 G.hns1.03
Hydrophobic ECL3 F 284 - G.hns1 K 32 G.hns1.03
Van-der-waals ECL3 F 284 - G.hns1 K 32 G.hns1.03
Polar ECL3 P 288 - G.S1 D 33 G.S1.01
Hydrophobic ECL3 P 288 - G.S1 D 33 G.S1.01
Van-der-waals ECL3 P 288 - G.S1 D 33 G.S1.01
Hydrophobic ECL3 R 281 - G.HN I 28 G.HN.52
Van-der-waals ECL3 R 281 - G.HN I 28 G.HN.52
Ionic TM7 E 303 7x44 H.HA R 86 H.HA.24
Polar ECL3 G 285 - G.HN S 29 G.HN.53
Hydrophobic ECL3 G 285 - G.HN S 29 G.HN.53
Van-der-waals ECL3 G 285 - G.HN S 29 G.HN.53
Hydrophobic TM3 E 143 3x52 G.H5 T 340 G.H5.12
Van-der-waals TM3 E 143 3x52 G.H5 T 340 G.H5.12
Polar ECL3 S 286 - G.HN I 28 G.HN.52
Polar ECL3 L 291 - G.S1 K 35 G.S1.03
Hydrophobic ECL3 L 291 - G.S1 K 35 G.S1.03
Polar ECL3 P 288 - G.S3 R 198 G.S3.04
Hydrophobic ECL3 P 288 - G.S3 R 198 G.S3.04
Van-der-waals ECL3 P 288 - G.S3 R 198 G.S3.04
Hydrophobic ECL3 P 288 - G.hns1 A 30 G.hns1.01
Hydrophobic TM7 Y 294 7x35 G.H2 K 211 G.H2.06
Van-der-waals TM7 Y 294 7x35 G.H2 K 211 G.H2.06
Hydrophobic TM1 I 74 1x60 G.s2s3 K 193 G.s2s3.01
Van-der-waals TM1 I 74 1x60 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM7 K 295 7x36 G.H2 H 214 G.H2.09
Van-der-waals TM7 K 295 7x36 G.H2 H 214 G.H2.09
Hydrophobic TM3 G 136 3x45 G.H5 L 348 G.H5.20
Van-der-waals TM3 G 136 3x45 G.H5 L 348 G.H5.20
Hydrophobic ECL3 I 290 - G.S3 F 200 G.S3.06
Van-der-waals ECL3 I 290 - G.S3 F 200 G.S3.06
Hydrophobic ECL3 F 292 - G.h2s4 V 219 G.h2s4.04
Van-der-waals ECL3 F 292 - G.h2s4 V 219 G.h2s4.04
Polar TM1 K 71 1x57 G.S3 H 196 G.S3.02
Hydrophobic TM1 K 71 1x57 G.S3 H 196 G.S3.02
Van-der-waals TM1 K 71 1x57 G.S3 H 196 G.S3.02
Hydrophobic ECL3 F 283 - G.S3 L 195 G.S3.01
Hydrophobic ECL3 L 291 - G.S3 F 200 G.S3.06
Polar TM7 C 296 7x37 G.H2 S 207 G.H2.02
Hydrophobic TM7 C 296 7x37 G.H2 S 207 G.H2.02
Van-der-waals TM7 C 296 7x37 G.H2 S 207 G.H2.02
Hydrophobic TM3 H 141 3x50 G.h4s6 E 318 G.h4s6.12
Hydrophobic ECL3 F 283 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ECL3 F 283 - G.s2s3 K 193 G.s2s3.01
Hydrophobic TM7 Y 294 7x35 G.H2 H 214 G.H2.09
Polar ECL3 R 281 - G.HN K 24 G.HN.48
Hydrophobic ECL3 F 292 - G.S1 K 35 G.S1.03
Van-der-waals ECL3 F 292 - G.S1 K 35 G.S1.03
Hydrophobic ICL1 S 77 - G.H5 F 336 G.H5.08
Polar ICL1 T 75 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL1 T 75 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL1 T 75 - G.s2s3 K 193 G.s2s3.01
Van-der-waals TM7 Q 297 7x38 G.H2 S 207 G.H2.02
Hydrophobic TM3 F 139 3x48 G.H5 Y 354 G.H5.26
Hydrophobic TM7 Y 294 7x35 G.S2 I 185 G.S2.01
Van-der-waals TM7 Y 294 7x35 G.S2 I 185 G.S2.01
Polar TM7 D 299 7x40 G.H2 S 207 G.H2.02
Hydrophobic TM7 D 299 7x40 G.H2 S 207 G.H2.02
Van-der-waals TM7 D 299 7x40 G.H2 S 207 G.H2.02
Hydrophobic ECL3 F 292 - G.S3 F 200 G.S3.06
Van-der-waals ECL3 F 292 - G.S3 F 200 G.S3.06
Hydrophobic TM7 K 295 7x36 G.H2 K 210 G.H2.05
Van-der-waals TM7 K 295 7x36 G.H2 K 210 G.H2.05
Hydrophobic TM3 E 143 3x52 G.H5 D 341 G.H5.13
Van-der-waals TM3 E 143 3x52 G.H5 D 341 G.H5.13
Hydrophobic TM7 Y 294 7x35 G.hfs2 G 184 G.hfs2.07
Van-der-waals TM7 Y 294 7x35 G.hfs2 G 184 G.hfs2.07
Polar ECL3 G 285 - G.hns1 K 32 G.hns1.03
Hydrophobic ECL3 G 285 - G.hns1 K 32 G.hns1.03
Van-der-waals ECL3 G 285 - G.hns1 K 32 G.hns1.03
Polar ECL3 G 282 - G.hns1 K 32 G.hns1.03
Hydrophobic ECL3 G 282 - G.hns1 K 32 G.hns1.03
Van-der-waals ECL3 G 282 - G.hns1 K 32 G.hns1.03
Hydrophobic TM7 V 306 7x47 H.hbhc T 117 H.hbhc.05
Hydrophobic ECL3 F 292 - G.S2 I 185 G.S2.01
Van-der-waals ECL3 F 292 - G.S2 I 185 G.S2.01
Hydrophobic TM1 I 74 1x60 G.S2 F 192 G.S2.08
Van-der-waals TM1 I 74 1x60 G.S2 F 192 G.S2.08
Polar ECL3 P 288 - G.HN S 29 G.HN.53
Hydrophobic ECL3 P 288 - G.HN S 29 G.HN.53
Van-der-waals ECL3 P 288 - G.HN S 29 G.HN.53
Polar TM7 C 296 7x37 G.H2 K 211 G.H2.06
Hydrophobic TM7 C 296 7x37 G.H2 K 211 G.H2.06
Van-der-waals TM7 C 296 7x37 G.H2 K 211 G.H2.06
Polar ICL1 S 76 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL1 S 76 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL1 S 76 - G.s2s3 K 193 G.s2s3.01
Hydrophobic TM1 K 71 1x57 G.S2 T 191 G.S2.07
Van-der-waals TM1 K 71 1x57 G.S2 T 191 G.S2.07
Polar ECL3 E 287 - G.HN S 29 G.HN.53
Van-der-waals ECL3 E 287 - G.HN S 29 G.HN.53
Hydrophobic ECL3 F 284 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ECL3 F 284 - G.s2s3 N 194 G.s2s3.02
Polar TM7 C 296 7x37 G.H2 E 208 G.H2.03
Hydrophobic TM7 C 296 7x37 G.H2 E 208 G.H2.03
Van-der-waals TM7 C 296 7x37 G.H2 E 208 G.H2.03
Polar TM7 Y 312 7x53 H.HA E 64 H.HA.02
Hydrophobic TM7 Y 312 7x53 H.HA E 64 H.HA.02
Van-der-waals TM7 Y 312 7x53 H.HA E 64 H.HA.02
Polar ECL3 S 293 - G.H2 C 215 G.H2.10
Hydrophobic ECL3 S 293 - G.H2 C 215 G.H2.10
Van-der-waals ECL3 S 293 - G.H2 C 215 G.H2.10
Van-der-waals TM7 D 299 7x40 G.H2 R 206 G.H2.01
Hydrophobic ECL3 S 286 - G.HN S 29 G.HN.53
Van-der-waals ECL3 S 286 - G.HN S 29 G.HN.53
Polar ECL3 F 292 - G.H2 C 215 G.H2.10
Hydrophobic ECL3 F 292 - G.H2 C 215 G.H2.10
Van-der-waals ECL3 F 292 - G.H2 C 215 G.H2.10
Hydrophobic ECL3 F 283 - G.H5 F 336 G.H5.08
Polar ECL3 S 293 - G.H2 H 214 G.H2.09
Hydrophobic ECL3 S 293 - G.H2 H 214 G.H2.09
Van-der-waals ECL3 S 293 - G.H2 H 214 G.H2.09
Polar ICL1 S 76 - G.H5 Q 333 G.H5.05
Hydrophobic ICL1 S 76 - G.H5 Q 333 G.H5.05
Van-der-waals ICL1 S 76 - G.H5 Q 333 G.H5.05
Hydrophobic ICL1 T 75 - G.H5 F 336 G.H5.08
Hydrophobic TM7 K 295 7x36 G.H2 I 213 G.H2.08
Hydrophobic ECL3 F 283 - G.hns1 K 32 G.hns1.03
Van-der-waals ECL3 F 283 - G.hns1 K 32 G.hns1.03
Hydrophobic TM3 E 143 3x52 G.H5 D 337 G.H5.09
Van-der-waals TM3 E 143 3x52 G.H5 D 337 G.H5.09
Polar TM7 Q 297 7x38 G.H2 K 210 G.H2.05
Hydrophobic TM7 Q 297 7x38 G.H2 K 210 G.H2.05
Van-der-waals TM7 Q 297 7x38 G.H2 K 210 G.H2.05
Polar TM7 Y 294 7x35 G.H2 W 212 G.H2.07
Aromatic TM7 Y 294 7x35 G.H2 W 212 G.H2.07
Hydrophobic TM7 Y 294 7x35 G.H2 W 212 G.H2.07
Van-der-waals TM7 Y 294 7x35 G.H2 W 212 G.H2.07
Polar ECL3 F 283 - G.s2s3 N 194 G.s2s3.02
Hydrophobic ECL3 F 283 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ECL3 F 283 - G.s2s3 N 194 G.s2s3.02
Polar ECL3 K 289 - G.S3 R 198 G.S3.04
Hydrophobic ECL3 K 289 - G.S3 R 198 G.S3.04
Van-der-waals ECL3 K 289 - G.S3 R 198 G.S3.04
Polar ECL3 S 286 - G.hns1 K 32 G.hns1.03
Hydrophobic ECL3 S 286 - G.hns1 K 32 G.hns1.03
Van-der-waals ECL3 S 286 - G.hns1 K 32 G.hns1.03
Hydrophobic ECL3 F 292 - G.S3 V 202 G.S3.08
Polar TM7 H 307 7x48 G.hfs2 T 183 G.hfs2.06
Hydrophobic TM7 H 307 7x48 G.hfs2 T 183 G.hfs2.06
Van-der-waals TM7 H 307 7x48 G.hfs2 T 183 G.hfs2.06
Hydrophobic ICL1 F 80 - G.H5 F 336 G.H5.08
Ionic TM7 D 299 7x40 G.H2 K 210 G.H2.05
Polar TM7 D 299 7x40 G.H2 K 210 G.H2.05
Hydrophobic TM7 D 299 7x40 G.H2 K 210 G.H2.05
Van-der-waals TM7 D 299 7x40 G.H2 K 210 G.H2.05
Hydrophobic TM7 L 308 7x49 H.HA V 72 H.HA.10
Van-der-waals TM7 L 308 7x49 H.HA V 72 H.HA.10
Hydrophobic ICL1 I 79 - G.H5 I 344 G.H5.16
Polar ECL3 I 290 - G.S3 R 198 G.S3.04
Hydrophobic ECL3 I 290 - G.S3 R 198 G.S3.04
Van-der-waals ECL3 I 290 - G.S3 R 198 G.S3.04
Hydrophobic TM7 P 304 7x45 H.hbhc M 114 H.hbhc.02
Ionic ECL3 E 287 - G.hns1 K 32 G.hns1.03
Polar ECL3 E 287 - G.hns1 K 32 G.hns1.03
Van-der-waals ECL3 E 287 - G.hns1 K 32 G.hns1.03
Hydrophobic ECL3 I 290 - G.h2s4 E 217 G.h2s4.02
Hydrophobic ECL3 S 286 - G.S3 H 196 G.S3.02
Van-der-waals ECL3 S 286 - G.S3 H 196 G.S3.02
Polar TM1 K 71 1x57 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM1 K 71 1x57 G.s2s3 N 194 G.s2s3.02
Van-der-waals TM1 K 71 1x57 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM1 K 71 1x57 G.s2s3 K 193 G.s2s3.01
Hydrophobic ECL3 S 293 - G.S2 I 185 G.S2.01
Van-der-waals ECL3 S 293 - G.S2 I 185 G.S2.01
Polar TM3 H 141 3x50 G.H5 D 341 G.H5.13
Polar TM7 Y 294 7x35 G.S3 V 202 G.S3.08
Hydrophobic TM7 Y 294 7x35 G.S3 V 202 G.S3.08
Van-der-waals TM7 Y 294 7x35 G.S3 V 202 G.S3.08
Ionic ECL3 E 287 - G.S3 H 196 G.S3.02
Polar ECL3 E 287 - G.S3 H 196 G.S3.02
Hydrophobic ECL3 E 287 - G.S3 H 196 G.S3.02
Van-der-waals ECL3 E 287 - G.S3 H 196 G.S3.02
Hydrophobic ECL3 G 282 - G.hns1 A 31 G.hns1.02
Van-der-waals ECL3 G 282 - G.hns1 A 31 G.hns1.02
Ionic TM7 D 305 7x46 G.hfs2 R 179 G.hfs2.02
Polar TM7 D 305 7x46 G.hfs2 R 179 G.hfs2.02
Polar TM7 Y 294 7x35 G.H2 E 208 G.H2.03
Hydrophobic TM7 Y 294 7x35 G.H2 E 208 G.H2.03
Van-der-waals TM7 Y 294 7x35 G.H2 E 208 G.H2.03
Hydrophobic TM3 G 140 3x49 G.H5 D 341 G.H5.13
Van-der-waals TM3 G 140 3x49 G.H5 D 341 G.H5.13