Refined structure (7BB7) of Gs - V2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (55.3%), 176 from model (44.7%)
Residue sidechains - 218 from structure (55.3%), 176 from model (44.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 AF2 AF2
G.s1h1 48 A G.s1h1.02 AF2 AF2
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 AF2 AF2
G.s1h1 52 G G.s1h1.06 AF2 AF2
G.H1 53 K G.H1.01 AF2 AF2
G.H1 54 S G.H1.02 AF2 AF2
G.H1 55 T G.H1.03 AF2 AF2
G.H1 56 I G.H1.04 AF2 AF2
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 AF2 AF2
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 Structure Structure
G.s4h3 261 N G.s4h3.12 Structure Structure
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 266 from structure (75.4%), 87 from model (24.6%)
Residue sidechains - 266 from structure (75.4%), 87 from model (24.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 L - AF2 AF2
N-term 3 M - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 H - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 S - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 Q - AF2 AF2
N-term 26 E - AF2 AF2
N-term 27 R - AF2 AF2
N-term 28 P - AF2 AF2
N-term 29 L - AF2 AF2
N-term 30 D - AF2 AF2
N-term 31 T - AF2 AF2
N-term 32 R - AF2 AF2
TM1 33 D 1.28x28 Structure Structure
TM1 34 P 1.29x29 Structure Structure
TM1 35 L 1.30x30 Structure Structure
TM1 36 L 1.31x31 Structure Structure
TM1 37 A 1.32x32 Structure Structure
TM1 38 R 1.33x33 Structure Structure
TM1 39 A 1.34x34 Structure Structure
TM1 40 E 1.35x35 Structure Structure
TM1 41 L 1.36x36 Structure Structure
TM1 42 A 1.37x37 Structure Structure
TM1 43 L 1.38x38 Structure Structure
TM1 44 L 1.39x39 Structure Structure
TM1 45 S 1.40x40 Structure Structure
TM1 46 I 1.41x41 Structure Structure
TM1 47 V 1.42x42 Structure Structure
TM1 48 F 1.43x43 Structure Structure
TM1 49 V 1.44x44 Structure Structure
TM1 50 A 1.45x45 Structure Structure
TM1 51 V 1.46x46 Structure Structure
TM1 52 A 1.47x47 Structure Structure
TM1 53 L 1.48x48 Structure Structure
TM1 54 S 1.49x49 Structure Structure
TM1 55 N 1.50x50 Structure Structure
TM1 56 G 1.51x51 Structure Structure
TM1 57 L 1.52x52 Structure Structure
TM1 58 V 1.53x53 Structure Structure
TM1 59 L 1.54x54 Structure Structure
TM1 60 A 1.55x55 Structure Structure
TM1 61 A 1.56x56 Structure Structure
TM1 62 L 1.57x57 Structure Structure
TM1 63 A 1.58x58 Structure Structure
TM1 64 R 1.59x59 Structure Structure
TM1 65 R 1.60x60 Structure Structure
TM1 66 G 1.61x61 Structure Structure
TM1 67 R 1.62x62 Structure Structure
TM1 68 R 1.63x63 Structure Structure
TM1 69 G 1.64x64 Structure Structure
ICL1 70 H - Structure Structure
ICL1 71 W - Structure Structure
TM2 72 A 2.37x37 Structure Structure
TM2 73 P 2.38x38 Structure Structure
TM2 74 I 2.39x39 Structure Structure
TM2 75 H 2.40x40 Structure Structure
TM2 76 V 2.41x41 Structure Structure
TM2 77 F 2.42x42 Structure Structure
TM2 78 I 2.43x43 Structure Structure
TM2 79 G 2.44x44 Structure Structure
TM2 80 H 2.45x45 Structure Structure
TM2 81 L 2.46x46 Structure Structure
TM2 82 C 2.47x47 Structure Structure
TM2 83 L 2.48x48 Structure Structure
TM2 84 A 2.49x49 Structure Structure
TM2 85 D 2.50x50 Structure Structure
TM2 86 L 2.51x51 Structure Structure
TM2 87 A 2.52x52 Structure Structure
TM2 88 V 2.53x53 Structure Structure
TM2 89 A 2.54x54 Structure Structure
TM2 90 L 2.55x55 Structure Structure
TM2 91 F 2.56x551 Structure Structure
TM2 92 Q 2.57x56 Structure Structure
TM2 93 V 2.58x57 Structure Structure
TM2 94 L 2.59x58 Structure Structure
TM2 95 P 2.60x59 Structure Structure
TM2 96 Q 2.61x60 Structure Structure
TM2 97 L 2.62x61 Structure Structure
TM2 98 A 2.63x62 Structure Structure
TM2 99 W 2.64x63 Structure Structure
TM2 100 K 2.65x64 Structure Structure
TM2 101 A 2.66x65 Structure Structure
TM2 102 T 2.67x66 Structure Structure
TM2 103 D 2.68x67 Structure Structure
ECL1 104 R 23.49x49 Structure Structure
ECL1 105 F 23.50x50 Structure Structure
ECL1 106 R 23.51x51 Structure Structure
ECL1 107 G 23.52x52 Structure Structure
TM3 108 P 3.21x21 Structure Structure
TM3 109 D 3.22x22 Structure Structure
TM3 110 A 3.23x23 Structure Structure
TM3 111 L 3.24x24 Structure Structure
TM3 112 C 3.25x25 Structure Structure
TM3 113 R 3.26x26 Structure Structure
TM3 114 A 3.27x27 Structure Structure
TM3 115 V 3.28x28 Structure Structure
TM3 116 K 3.29x29 Structure Structure
TM3 117 Y 3.30x30 Structure Structure
TM3 118 L 3.31x31 Structure Structure
TM3 119 Q 3.32x32 Structure Structure
TM3 120 M 3.33x33 Structure Structure
TM3 121 V 3.34x34 Structure Structure
TM3 122 G 3.35x35 Structure Structure
TM3 123 M 3.36x36 Structure Structure
TM3 124 Y 3.37x37 Structure Structure
TM3 125 A 3.38x38 Structure Structure
TM3 126 S 3.39x39 Structure Structure
TM3 127 S 3.40x40 Structure Structure
TM3 128 Y 3.41x41 Structure Structure
TM3 129 M 3.42x42 Structure Structure
TM3 130 I 3.43x43 Structure Structure
TM3 131 L 3.44x44 Structure Structure
TM3 132 A 3.45x45 Structure Structure
TM3 133 M 3.46x46 Structure Structure
TM3 134 T 3.47x47 Structure Structure
TM3 135 L 3.48x48 Structure Structure
TM3 136 D 3.49x49 Structure Structure
TM3 137 R 3.50x50 Structure Structure
TM3 138 H 3.51x51 Structure Structure
TM3 139 R 3.52x52 Structure Structure
TM3 140 A 3.53x53 Structure Structure
TM3 141 I 3.54x54 Structure Structure
TM3 142 C 3.55x55 Structure Structure
TM3 143 R 3.56x56 AF2 AF2
ICL2 144 P 34.50x50 AF2 AF2
ICL2 145 M 34.51x51 AF2 AF2
ICL2 146 L 34.52x52 AF2 AF2
ICL2 147 A 34.53x53 AF2 AF2
ICL2 148 Y 34.54x54 AF2 AF2
ICL2 149 R 34.55x55 AF2 AF2
ICL2 150 H 34.56x56 AF2 AF2
ICL2 151 G 34.57x57 AF2 AF2
TM4 152 S 4.38x38 AF2 AF2
TM4 153 G 4.39x39 AF2 AF2
TM4 154 A 4.40x40 AF2 AF2
TM4 155 H 4.41x41 AF2 AF2
TM4 156 W 4.42x42 AF2 AF2
TM4 157 N 4.43x43 AF2 AF2
TM4 158 R 4.44x44 Structure Structure
TM4 159 P 4.45x45 Structure Structure
TM4 160 V 4.46x46 Structure Structure
TM4 161 L 4.47x47 Structure Structure
TM4 162 V 4.48x48 Structure Structure
TM4 163 A 4.49x49 Structure Structure
TM4 164 W 4.50x50 Structure Structure
TM4 165 A 4.51x51 Structure Structure
TM4 166 F 4.52x52 Structure Structure
TM4 167 S 4.53x53 Structure Structure
TM4 168 L 4.54x54 Structure Structure
TM4 169 L 4.55x55 Structure Structure
TM4 170 L 4.56x56 Structure Structure
TM4 171 S 4.57x57 Structure Structure
TM4 172 L 4.58x59 Structure Structure
TM4 173 P 4.59x60 Structure Structure
TM4 174 Q 4.60x61 Structure Structure
TM4 175 L 4.61x62 Structure Structure
TM4 176 F 4.62x63 Structure Structure
TM4 177 I 4.63x64 Structure Structure
TM4 178 F 4.64x65 Structure Structure
ECL2 179 A - Structure Structure
ECL2 180 Q - Structure Structure
ECL2 181 R - Structure Structure
ECL2 182 N - Structure Structure
ECL2 183 V - Structure Structure
ECL2 184 E - Structure Structure
ECL2 185 G - Structure Structure
ECL2 186 G - Structure Structure
ECL2 187 S - Structure Structure
ECL2 188 G - Structure Structure
ECL2 189 V - Structure Structure
ECL2 190 T - Structure Structure
ECL2 191 D - Structure Structure
ECL2 192 C 45.50x50 Structure Structure
ECL2 193 W 45.51x51 Structure Structure
ECL2 194 A 45.52x52 Structure Structure
ECL2 195 C - Structure Structure
ECL2 196 F - Structure Structure
ECL2 197 A - Structure Structure
ECL2 198 E - Structure Structure
ECL2 199 P - Structure Structure
TM5 200 W 5.33x34 Structure Structure
TM5 201 G 5.34x35 Structure Structure
TM5 202 R 5.35x36 Structure Structure
TM5 203 R 5.36x37 Structure Structure
TM5 204 T 5.37x38 Structure Structure
TM5 205 Y 5.38x39 Structure Structure
TM5 206 V 5.39x40 Structure Structure
TM5 207 T 5.40x41 Structure Structure
TM5 208 W 5.41x42 Structure Structure
TM5 209 I 5.42x43 Structure Structure
TM5 210 A 5.43x44 Structure Structure
TM5 211 L 5.44x45 Structure Structure
TM5 212 M 5.45x46 Structure Structure
TM5 213 V 5.46x461 Structure Structure
TM5 214 F 5.47x47 Structure Structure
TM5 215 V 5.48x48 Structure Structure
TM5 216 A 5.49x49 Structure Structure
TM5 217 P 5.50x50 Structure Structure
TM5 218 T 5.51x51 Structure Structure
TM5 219 L 5.52x52 Structure Structure
TM5 220 G 5.53x53 Structure Structure
TM5 221 I 5.54x54 Structure Structure
TM5 222 A 5.55x55 Structure Structure
TM5 223 A 5.56x56 Structure Structure
TM5 224 C 5.57x57 Structure Structure
TM5 225 Q 5.58x58 Structure Structure
TM5 226 V 5.59x59 Structure Structure
TM5 227 L 5.60x60 Structure Structure
TM5 228 I 5.61x61 Structure Structure
TM5 229 F 5.62x62 Structure Structure
TM5 230 R 5.63x63 Structure Structure
TM5 231 E 5.64x64 Structure Structure
TM5 232 I 5.65x65 Structure Structure
TM5 233 H 5.66x66 Structure Structure
TM5 234 A 5.67x67 Structure Structure
TM5 235 S 5.68x68 Structure Structure
TM5 236 L 5.69x69 AF2 AF2
TM5 237 V 5.70x70 AF2 AF2
TM5 238 P 5.71x71 AF2 AF2
TM5 239 G 5.72x72 AF2 AF2
TM5 240 P 5.73x73 AF2 AF2
TM5 241 S 5.74x74 AF2 AF2
TM5 242 E 5.75x75 AF2 AF2
TM5 243 R 5.76x76 AF2 AF2
ICL3 244 P - AF2 AF2
ICL3 245 G - AF2 AF2
ICL3 246 G - AF2 AF2
ICL3 247 R - AF2 AF2
ICL3 248 R - AF2 AF2
ICL3 249 R - AF2 AF2
ICL3 250 G - AF2 AF2
ICL3 253 T - AF2 AF2
ICL3 254 G - AF2 AF2
ICL3 255 S - AF2 AF2
ICL3 256 P - AF2 AF2
ICL3 257 G - AF2 AF2
ICL3 258 E - AF2 AF2
ICL3 259 G - AF2 AF2
TM6 260 A 6.24x24 AF2 AF2
TM6 261 H 6.25x25 AF2 AF2
TM6 262 V 6.26x26 AF2 AF2
TM6 263 S 6.27x27 Structure Structure
TM6 264 A 6.28x28 Structure Structure
TM6 265 A 6.29x29 Structure Structure
TM6 266 V 6.30x30 Structure Structure
TM6 267 A 6.31x31 Structure Structure
TM6 268 K 6.32x32 Structure Structure
TM6 269 T 6.33x33 Structure Structure
TM6 270 V 6.34x34 Structure Structure
TM6 271 R 6.35x35 Structure Structure
TM6 272 M 6.36x36 Structure Structure
TM6 273 T 6.37x37 Structure Structure
TM6 274 L 6.38x38 Structure Structure
TM6 275 V 6.39x39 Structure Structure
TM6 276 I 6.40x40 Structure Structure
TM6 277 V 6.41x41 Structure Structure
TM6 278 V 6.42x42 Structure Structure
TM6 279 V 6.43x43 Structure Structure
TM6 280 Y 6.44x44 Structure Structure
TM6 281 V 6.45x45 Structure Structure
TM6 282 L 6.46x46 Structure Structure
TM6 283 C 6.47x47 Structure Structure
TM6 284 W 6.48x48 Structure Structure
TM6 285 A 6.49x49 Structure Structure
TM6 286 P 6.50x50 Structure Structure
TM6 287 F 6.51x51 Structure Structure
TM6 288 F 6.52x52 Structure Structure
TM6 289 L 6.53x53 Structure Structure
TM6 290 V 6.54x54 Structure Structure
TM6 291 Q 6.55x55 Structure Structure
TM6 292 L 6.56x56 Structure Structure
TM6 293 W 6.57x57 Structure Structure
TM6 294 A 6.58x58 Structure Structure
TM6 295 A 6.59x59 Structure Structure
TM6 296 W 6.60x60 Structure Structure
TM6 297 D 6.61x61 Structure Structure
ECL3 298 P - Structure Structure
ECL3 299 E - Structure Structure
ECL3 300 A - Structure Structure
ECL3 301 P - Structure Structure
ECL3 302 L - Structure Structure
ECL3 303 E - Structure Structure
TM7 304 G 7.32x31 Structure Structure
TM7 305 A 7.33x32 Structure Structure
TM7 306 P 7.34x33 Structure Structure
TM7 307 F 7.35x34 Structure Structure
TM7 308 V 7.36x35 Structure Structure
TM7 309 L 7.37x36 Structure Structure
TM7 310 L 7.38x37 Structure Structure
TM7 311 M 7.39x38 Structure Structure
TM7 312 L 7.40x39 Structure Structure
TM7 313 L 7.41x40 Structure Structure
TM7 314 A 7.42x41 Structure Structure
TM7 315 S 7.43x42 Structure Structure
TM7 316 L 7.44x43 Structure Structure
TM7 317 N 7.45x45 Structure Structure
TM7 318 S 7.46x46 Structure Structure
TM7 319 C 7.47x47 Structure Structure
TM7 320 T 7.48x48 Structure Structure
TM7 321 N 7.49x49 Structure Structure
TM7 322 P 7.50x50 Structure Structure
TM7 323 W 7.51x51 Structure Structure
TM7 324 I 7.52x52 Structure Structure
TM7 325 Y 7.53x53 Structure Structure
TM7 326 A 7.54x54 Structure Structure
TM7 327 S 7.55x55 Structure Structure
TM7 328 F 7.56x56 Structure Structure
H8 329 S 8.47x47 Structure Structure
H8 330 S 8.48x48 Structure Structure
H8 331 S 8.49x49 Structure Structure
H8 332 V 8.50x50 Structure Structure
H8 333 S 8.51x51 Structure Structure
H8 334 S 8.52x52 Structure Structure
H8 335 E 8.53x53 Structure Structure
H8 336 L 8.54x54 Structure Structure
H8 337 R 8.55x55 Structure Structure
H8 338 S 8.56x56 Structure Structure
H8 339 L 8.57x57 Structure Structure
H8 340 L 8.58x58 Structure Structure
H8 341 C 8.59x59 AF2 AF2
H8 342 C 8.60x60 AF2 AF2
H8 343 A 8.61x61 AF2 AF2
H8 344 R 8.62x62 AF2 AF2
H8 345 G 8.63x63 AF2 AF2
C-term 346 R - AF2 AF2
C-term 347 T - AF2 AF2
C-term 348 P - AF2 AF2
C-term 349 P - AF2 AF2
C-term 350 S - AF2 AF2
C-term 351 L - AF2 AF2
C-term 352 G - AF2 AF2
C-term 353 P - AF2 AF2
C-term 354 Q - AF2 AF2
C-term 355 D - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 144 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 144 34x50 G.H5 I 383 G.H5.15
Polar ICL2 R 149 34x55 G.S3 N 218 G.S3.02
Hydrophobic ICL2 R 149 34x55 G.S3 N 218 G.S3.02
Van-der-waals ICL2 R 149 34x55 G.S3 N 218 G.S3.02
Polar ICL3 G 246 - G.H4 Y 339 G.H4.08
Polar TM5 E 242 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 E 242 5x75 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 E 242 5x75 G.hgh4 D 323 G.hgh4.13
Polar ICL2 A 147 34x53 G.S1 T 40 G.S1.01
Hydrophobic ICL2 A 147 34x53 G.S1 T 40 G.S1.01
Polar TM3 R 137 3x50 G.H5 L 394 G.H5.26
Hydrophobic TM3 R 137 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 137 3x50 G.H5 L 394 G.H5.26
Polar ICL3 G 250 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 G 250 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 G 250 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL2 M 145 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 M 145 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 P 240 5x73 G.S6 P 361 G.S6.03
Van-der-waals TM5 P 240 5x73 G.S6 P 361 G.S6.03
Polar TM3 D 136 3x49 G.H5 Y 391 G.H5.23
Polar TM4 S 152 4x38 G.HN V 36 G.HN.53
Hydrophobic TM4 S 152 4x38 G.HN V 36 G.HN.53
Van-der-waals TM4 S 152 4x38 G.HN V 36 G.HN.53
Hydrophobic TM4 G 153 4x39 G.hns1 A 39 G.hns1.03
Polar TM6 H 261 6x25 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 H 261 6x25 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM6 H 261 6x25 G.h4s6 T 350 G.h4s6.03
Van-der-waals C-term D 355 - G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 G 151 34x57 G.HN V 36 G.HN.53
Van-der-waals ICL2 G 151 34x57 G.HN V 36 G.HN.53
Polar ICL3 R 247 - G.hgh4 A 324 G.hgh4.14
Hydrophobic ICL3 R 247 - G.hgh4 A 324 G.hgh4.14
Van-der-waals ICL3 R 247 - G.hgh4 A 324 G.hgh4.14
Hydrophobic TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Polar ICL3 G 254 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 G 254 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 G 254 - G.H4 D 343 G.H4.13
Polar ICL3 R 247 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 247 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 247 - G.hgh4 D 323 G.hgh4.13
Polar TM4 S 152 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM4 S 152 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 S 152 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 A 140 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 H 387 G.H5.19
Polar ICL2 Y 148 34x54 G.S3 F 219 G.S3.03
Hydrophobic ICL2 Y 148 34x54 G.S3 F 219 G.S3.03
Aromatic ICL2 R 149 34x55 G.H5 F 376 G.H5.08
Hydrophobic ICL2 R 149 34x55 G.H5 F 376 G.H5.08
Van-der-waals ICL2 R 149 34x55 G.H5 F 376 G.H5.08
Polar TM4 A 154 4x40 G.HN Q 35 G.HN.52
Hydrophobic TM4 A 154 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM4 A 154 4x40 G.HN Q 35 G.HN.52
Hydrophobic ICL2 P 144 34x50 G.H5 F 376 G.H5.08
Van-der-waals ICL2 P 144 34x50 G.H5 F 376 G.H5.08
Polar ICL3 G 246 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 G 246 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 G 246 - G.hgh4 T 325 G.hgh4.15
Polar ICL2 Y 148 34x54 G.S1 T 40 G.S1.01
Hydrophobic ICL2 Y 148 34x54 G.S1 T 40 G.S1.01
Van-der-waals ICL2 Y 148 34x54 G.S1 T 40 G.S1.01
Polar ICL3 S 255 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic ICL3 S 255 - G.hgh4 Y 318 G.hgh4.08
Van-der-waals ICL3 S 255 - G.hgh4 Y 318 G.hgh4.08
Ionic TM5 E 242 5x75 G.H4 R 342 G.H4.12
Polar TM5 E 242 5x75 G.H4 R 342 G.H4.12
Hydrophobic TM5 E 242 5x75 G.H4 R 342 G.H4.12
Van-der-waals TM5 E 242 5x75 G.H4 R 342 G.H4.12
Hydrophobic ICL3 G 246 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 G 246 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM2 I 74 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 I 74 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM6 M 272 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 272 6x36 G.H5 L 393 G.H5.25
Polar ICL3 R 248 - G.hgh4 A 324 G.hgh4.14
Hydrophobic ICL3 R 248 - G.hgh4 A 324 G.hgh4.14
Van-der-waals ICL3 R 248 - G.hgh4 A 324 G.hgh4.14
Hydrophobic TM5 P 240 5x73 G.H4 L 346 G.H4.16
Van-der-waals TM5 P 240 5x73 G.H4 L 346 G.H4.16
Polar ICL3 S 255 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 S 255 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 S 255 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 A 147 34x53 G.S1 H 41 G.S1.02
Polar ICL2 R 149 34x55 G.S2 V 214 G.S2.08
Hydrophobic ICL2 R 149 34x55 G.S2 V 214 G.S2.08
Van-der-waals ICL2 R 149 34x55 G.S2 V 214 G.S2.08
Hydrophobic TM6 T 269 6x33 G.H5 R 385 G.H5.17
Hydrophobic TM5 E 242 5x75 G.hgh4 P 321 G.hgh4.11
Van-der-waals TM5 E 242 5x75 G.hgh4 P 321 G.hgh4.11
Polar H8 S 329 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 S 329 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 S 329 8x47 G.H5 Q 390 G.H5.22
Hydrophobic ICL3 G 245 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 G 245 - G.hgh4 T 325 G.hgh4.15
Polar TM5 S 241 5x74 G.H4 K 338 G.H4.07
Hydrophobic TM5 S 241 5x74 G.H4 K 338 G.H4.07
Van-der-waals TM5 S 241 5x74 G.H4 K 338 G.H4.07
Hydrophobic ICL3 R 248 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 R 248 - G.hgh4 P 321 G.hgh4.11
Polar ICL3 R 249 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 R 249 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 R 249 - G.hgh4 E 322 G.hgh4.12
Polar ICL2 G 151 34x57 G.S3 N 218 G.S3.02
Van-der-waals ICL2 G 151 34x57 G.S3 N 218 G.S3.02
Hydrophobic ICL3 T 253 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 T 253 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL3 G 257 - G.h4s6 A 351 G.h4s6.04
Van-der-waals ICL3 G 257 - G.h4s6 A 351 G.h4s6.04
Polar TM1 R 64 1x59 G.H5 Q 390 G.H5.22
Van-der-waals TM1 R 64 1x59 G.H5 Q 390 G.H5.22
Hydrophobic TM3 A 140 3x53 G.H5 I 383 G.H5.15
Polar TM1 G 69 1x64 G.HN Q 35 G.HN.52
Ionic TM3 D 136 3x49 G.H5 H 387 G.H5.19
Polar TM3 D 136 3x49 G.H5 H 387 G.H5.19
Hydrophobic TM6 M 272 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 M 272 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 M 145 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 145 34x51 G.H5 F 376 G.H5.08
Ionic ICL2 R 149 34x55 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 149 34x55 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 149 34x55 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 149 34x55 G.s2s3 D 215 G.s2s3.01
Polar ICL2 Y 148 34x54 G.H5 C 379 G.H5.11
Van-der-waals ICL2 Y 148 34x54 G.H5 C 379 G.H5.11
Ionic ICL3 E 258 - G.H4 R 342 G.H4.12
Polar ICL3 E 258 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 E 258 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 E 258 - G.H4 R 342 G.H4.12
Polar ICL1 H 70 - G.HN Q 35 G.HN.52
Hydrophobic ICL1 H 70 - G.HN Q 35 G.HN.52
Van-der-waals ICL1 H 70 - G.HN Q 35 G.HN.52
Polar ICL3 G 250 - G.hgh4 T 320 G.hgh4.10
Hydrophobic ICL3 G 250 - G.hgh4 T 320 G.hgh4.10
Van-der-waals ICL3 G 250 - G.hgh4 T 320 G.hgh4.10
Hydrophobic TM3 I 141 3x54 G.H5 L 394 G.H5.26
Van-der-waals TM3 I 141 3x54 G.H5 L 394 G.H5.26
Ionic C-term D 355 - G.h3s5 R 283 G.h3s5.01
Polar C-term D 355 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term D 355 - G.h3s5 R 283 G.h3s5.01
Polar TM5 E 242 5x75 G.H4 Y 339 G.H4.08
Hydrophobic TM5 E 242 5x75 G.H4 Y 339 G.H4.08
Van-der-waals TM5 E 242 5x75 G.H4 Y 339 G.H4.08
Hydrophobic TM2 A 72 2x37 G.hns1 A 39 G.hns1.03
Van-der-waals TM2 A 72 2x37 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 I 141 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM7 S 327 7x55 G.H5 L 393 G.H5.25
Van-der-waals TM7 S 327 7x55 G.H5 L 393 G.H5.25
Polar TM4 H 155 4x41 G.HN Q 35 G.HN.52
Hydrophobic TM4 H 155 4x41 G.HN Q 35 G.HN.52
Van-der-waals TM4 H 155 4x41 G.HN Q 35 G.HN.52
Hydrophobic ICL2 M 145 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 M 145 34x51 G.S3 V 217 G.S3.01
Polar ICL3 R 248 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 248 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 248 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 P 244 - G.hgh4 T 325 G.hgh4.15
Hydrophobic TM5 P 240 5x73 G.H4 R 342 G.H4.12
Van-der-waals TM5 P 240 5x73 G.H4 R 342 G.H4.12
Hydrophobic TM4 A 154 4x40 G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 R 249 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 249 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM2 I 74 2x39 G.H5 H 387 G.H5.19
Hydrophobic ICL2 G 151 34x57 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 M 145 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 M 145 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM3 M 133 3x46 G.H5 Y 391 G.H5.23
Polar ICL3 E 258 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 E 258 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 E 258 - G.H4 D 343 G.H4.13
Polar TM3 A 140 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 140 3x53 G.H5 Q 384 G.H5.16
Van-der-waals TM3 A 140 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 141 3x54 G.H5 L 388 G.H5.20
Polar ICL3 T 253 - G.hgh4 T 319 G.hgh4.09
Hydrophobic ICL3 T 253 - G.hgh4 T 319 G.hgh4.09
Van-der-waals ICL3 T 253 - G.hgh4 T 319 G.hgh4.09
Hydrophobic TM5 V 237 5x70 G.hgh4 E 322 G.hgh4.12
Van-der-waals TM5 V 237 5x70 G.hgh4 E 322 G.hgh4.12
Polar ICL2 Y 148 34x54 G.H5 I 383 G.H5.15
Hydrophobic ICL2 Y 148 34x54 G.H5 I 383 G.H5.15
Van-der-waals ICL2 Y 148 34x54 G.H5 I 383 G.H5.15
Polar ICL3 T 253 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 T 253 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 T 253 - G.H4 D 343 G.H4.13
Polar ICL2 R 149 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 R 149 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 149 34x55 G.s2s3 K 216 G.s2s3.02
Polar TM5 S 241 5x74 G.H4 F 340 G.H4.10
Polar TM4 G 153 4x39 G.HN Q 35 G.HN.52
Hydrophobic TM4 G 153 4x39 G.HN Q 35 G.HN.52
Van-der-waals TM4 G 153 4x39 G.HN Q 35 G.HN.52
Polar ICL2 H 150 34x56 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 H 150 34x56 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 H 150 34x56 G.s2s3 K 216 G.s2s3.02
Polar TM5 R 243 5x76 G.S6 H 362 G.S6.04
Aromatic TM5 R 243 5x76 G.S6 H 362 G.S6.04
Hydrophobic TM5 R 243 5x76 G.S6 H 362 G.S6.04
Van-der-waals TM5 R 243 5x76 G.S6 H 362 G.S6.04
Polar ICL2 R 149 34x55 G.S3 V 217 G.S3.01
Hydrophobic ICL2 R 149 34x55 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 149 34x55 G.S3 V 217 G.S3.01
Polar ICL3 T 253 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic ICL3 T 253 - G.hgh4 Y 318 G.hgh4.08
Van-der-waals ICL3 T 253 - G.hgh4 Y 318 G.hgh4.08
Polar TM5 S 241 5x74 G.H4 R 342 G.H4.12
Hydrophobic TM5 S 241 5x74 G.H4 R 342 G.H4.12
Van-der-waals TM5 S 241 5x74 G.H4 R 342 G.H4.12
Hydrophobic TM6 I 276 6x40 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 276 6x40 G.H5 L 393 G.H5.25
Polar ICL2 Y 148 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 Y 148 34x54 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 Y 148 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 146 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 L 146 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic H8 S 329 8x47 G.H5 Y 391 G.H5.23
Polar ICL3 R 248 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 R 248 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 R 248 - G.hgh4 E 322 G.hgh4.12
Van-der-waals TM3 A 140 3x53 G.H5 R 380 G.H5.12
Polar ICL3 R 249 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL3 R 249 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 R 249 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL2 L 146 34x52 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 L 146 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 A 147 34x53 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 A 147 34x53 G.hns1 A 39 G.hns1.03
Hydrophobic TM7 F 328 7x56 G.H5 L 393 G.H5.25
Van-der-waals TM7 F 328 7x56 G.H5 L 393 G.H5.25
Hydrophobic TM5 G 239 5x72 G.H4 R 342 G.H4.12
Van-der-waals TM5 G 239 5x72 G.H4 R 342 G.H4.12
Hydrophobic TM7 F 328 7x56 G.H5 E 392 G.H5.24
Polar TM5 E 242 5x75 G.hgh4 E 322 G.hgh4.12
Hydrophobic TM5 E 242 5x75 G.hgh4 E 322 G.hgh4.12
Van-der-waals TM5 E 242 5x75 G.hgh4 E 322 G.hgh4.12
Polar TM4 S 152 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 S 152 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 S 152 4x38 G.HN Q 35 G.HN.52
Polar TM4 S 152 4x38 G.hns1 A 39 G.hns1.03
Hydrophobic TM4 S 152 4x38 G.hns1 A 39 G.hns1.03
Van-der-waals TM4 S 152 4x38 G.hns1 A 39 G.hns1.03
Hydrophobic TM4 G 153 4x39 G.HN V 36 G.HN.53
Hydrophobic ICL3 G 254 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 G 254 - G.H4 R 342 G.H4.12
Van-der-waals TM2 V 76 2x41 G.hns1 R 38 G.hns1.02
Polar ICL3 R 249 - G.hgh4 T 320 G.hgh4.10
Hydrophobic ICL3 R 249 - G.hgh4 T 320 G.hgh4.10
Van-der-waals ICL3 R 249 - G.hgh4 T 320 G.hgh4.10
Hydrophobic TM3 M 133 3x46 G.H5 L 394 G.H5.26
Van-der-waals TM3 M 133 3x46 G.H5 L 394 G.H5.26
Polar TM5 R 243 5x76 G.S6 P 361 G.S6.03
Hydrophobic TM5 R 243 5x76 G.S6 P 361 G.S6.03
Van-der-waals TM5 R 243 5x76 G.S6 P 361 G.S6.03
Hydrophobic ICL3 E 258 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 E 258 - G.H4 L 346 G.H4.16
Hydrophobic TM2 I 78 2x43 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 143 3x56 G.H5 F 376 G.H5.08
Polar ICL3 T 253 - G.hgh4 T 320 G.hgh4.10
Hydrophobic ICL3 T 253 - G.hgh4 T 320 G.hgh4.10
Van-der-waals ICL3 T 253 - G.hgh4 T 320 G.hgh4.10
Hydrophobic TM2 P 73 2x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 P 73 2x38 G.hns1 R 38 G.hns1.02
Polar ICL2 Y 148 34x54 G.S3 N 218 G.S3.02
Hydrophobic ICL2 Y 148 34x54 G.S3 N 218 G.S3.02
Van-der-waals ICL2 Y 148 34x54 G.S3 N 218 G.S3.02
Polar ICL3 P 244 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 P 244 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 M 145 34x51 G.H5 V 375 G.H5.07
Van-der-waals ICL2 M 145 34x51 G.H5 V 375 G.H5.07
Polar ICL3 G 250 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 G 250 - G.H4 R 342 G.H4.12
Polar ICL3 G 246 - G.hgh4 A 324 G.hgh4.14
Hydrophobic ICL3 G 246 - G.hgh4 A 324 G.hgh4.14
Van-der-waals ICL3 G 246 - G.hgh4 A 324 G.hgh4.14
Hydrophobic ICL3 G 254 - G.hgh4 Y 318 G.hgh4.08
Van-der-waals ICL3 G 254 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM3 R 143 3x56 G.H5 R 380 G.H5.12
Hydrophobic ICL2 M 145 34x51 G.S2 V 214 G.S2.08
Polar ICL2 Y 148 34x54 G.S1 H 41 G.S1.02
Aromatic ICL2 Y 148 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 148 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Y 148 34x54 G.S1 H 41 G.S1.02
Polar TM4 S 152 4x38 G.S1 T 40 G.S1.01
Hydrophobic TM4 S 152 4x38 G.S1 T 40 G.S1.01
Van-der-waals TM4 S 152 4x38 G.S1 T 40 G.S1.01
Hydrophobic TM4 H 155 4x41 G.HN K 32 G.HN.49
Hydrophobic ICL2 P 144 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 144 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 G 151 34x57 G.S1 T 40 G.S1.01
Hydrophobic TM6 T 273 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 228 5x61 G.H5 Q 384 G.H5.16
Van-der-waals TM5 I 228 5x61 G.H5 Q 384 G.H5.16
Polar TM4 S 152 4x38 G.hns1 Y 37 G.hns1.01
Hydrophobic TM4 S 152 4x38 G.hns1 Y 37 G.hns1.01
Van-der-waals TM4 S 152 4x38 G.hns1 Y 37 G.hns1.01
Ionic TM5 R 243 5x76 G.H5 D 378 G.H5.10
Polar TM5 R 243 5x76 G.H5 D 378 G.H5.10
Hydrophobic TM5 E 231 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 E 231 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL3 R 247 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 R 247 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM5 G 239 5x72 G.S6 P 361 G.S6.03
Van-der-waals TM5 G 239 5x72 G.S6 P 361 G.S6.03
Polar ICL1 H 70 - G.HN Q 31 G.HN.48
Hydrophobic ICL2 Y 148 34x54 G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 148 34x54 G.S3 V 217 G.S3.01
Polar TM5 S 241 5x74 G.H4 D 343 G.H4.13
Hydrophobic TM7 F 328 7x56 G.H5 Y 391 G.H5.23
Van-der-waals TM7 F 328 7x56 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 228 5x61 G.H5 L 388 G.H5.20
Polar TM5 S 241 5x74 G.H4 Y 339 G.H4.08
Hydrophobic TM5 S 241 5x74 G.H4 Y 339 G.H4.08
Van-der-waals TM5 S 241 5x74 G.H4 Y 339 G.H4.08
Polar ICL3 G 250 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL3 G 250 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 G 250 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL3 G 254 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 G 254 - G.hgh4 P 321 G.hgh4.11
Polar TM6 H 261 6x25 G.h4s6 A 351 G.h4s6.04
Hydrophobic TM6 H 261 6x25 G.h4s6 A 351 G.h4s6.04
Van-der-waals TM6 H 261 6x25 G.h4s6 A 351 G.h4s6.04