Refined structure (7CMU) of Gi1 - D3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (63.6%), 129 from model (36.4%)
Residue sidechains - 221 from structure (62.4%), 133 from model (37.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 Structure Structure
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 Structure Structure
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 272 from structure (84.2%), 51 from model (15.8%)
Residue sidechains - 272 from structure (84.2%), 51 from model (15.8%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 Q - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 H - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 N - AF2 AF2
N-term 13 Y - AF2 AF2
N-term 14 T - AF2 AF2
N-term 15 C - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 E - AF2 AF2
N-term 19 N - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 G - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 Q - AF2 AF2
TM1 26 A 1.29x29 AF2 AF2
TM1 27 R 1.30x30 AF2 AF2
TM1 28 P 1.31x31 AF2 AF2
TM1 29 H 1.32x32 AF2 AF2
TM1 30 A 1.33x33 AF2 AF2
TM1 31 Y 1.34x34 AF2 AF2
TM1 32 Y 1.35x35 Structure Structure
TM1 33 A 1.36x36 Structure Structure
TM1 34 L 1.37x37 Structure Structure
TM1 35 S 1.38x38 Structure Structure
TM1 36 Y 1.39x39 Structure Structure
TM1 37 C 1.40x40 Structure Structure
TM1 38 A 1.41x41 Structure Structure
TM1 39 L 1.42x42 Structure Structure
TM1 40 I 1.43x43 Structure Structure
TM1 41 L 1.44x44 Structure Structure
TM1 42 A 1.45x45 Structure Structure
TM1 43 I 1.46x46 Structure Structure
TM1 44 V 1.47x47 Structure Structure
TM1 45 F 1.48x48 Structure Structure
TM1 46 G 1.49x49 Structure Structure
TM1 47 N 1.50x50 Structure Structure
TM1 48 G 1.51x51 Structure Structure
TM1 49 L 1.52x52 Structure Structure
TM1 50 V 1.53x53 Structure Structure
TM1 51 C 1.54x54 Structure Structure
TM1 52 M 1.55x55 Structure Structure
TM1 53 A 1.56x56 Structure Structure
TM1 54 V 1.57x57 Structure Structure
TM1 55 L 1.58x58 Structure Structure
TM1 56 K 1.59x59 Structure Structure
TM1 57 E 1.60x60 Structure Structure
ICL1 58 R 12.48x48 Structure Structure
ICL1 59 A 12.49x49 Structure Structure
ICL1 60 L 12.50x50 Structure Structure
ICL1 61 Q 12.51x51 Structure Structure
TM2 62 T 2.37x37 Structure Structure
TM2 63 T 2.38x38 Structure Structure
TM2 64 T 2.39x39 Structure Structure
TM2 65 N 2.40x40 Structure Structure
TM2 66 Y 2.41x41 Structure Structure
TM2 67 L 2.42x42 Structure Structure
TM2 68 V 2.43x43 Structure Structure
TM2 69 V 2.44x44 Structure Structure
TM2 70 S 2.45x45 Structure Structure
TM2 71 L 2.46x46 Structure Structure
TM2 72 A 2.47x47 Structure Structure
TM2 73 V 2.48x48 Structure Structure
TM2 74 A 2.49x49 Structure Structure
TM2 75 D 2.50x50 Structure Structure
TM2 76 L 2.51x51 Structure Structure
TM2 77 L 2.52x52 Structure Structure
TM2 78 V 2.53x53 Structure Structure
TM2 79 A 2.54x54 Structure Structure
TM2 80 T 2.55x55 Structure Structure
TM2 81 L 2.56x551 Structure Structure
TM2 82 V 2.57x56 Structure Structure
TM2 83 M 2.58x57 Structure Structure
TM2 84 P 2.59x58 Structure Structure
TM2 85 W 2.60x59 Structure Structure
TM2 86 V 2.61x60 Structure Structure
TM2 87 V 2.62x61 Structure Structure
TM2 88 Y 2.63x62 Structure Structure
TM2 89 L 2.64x63 Structure Structure
TM2 90 E 2.65x64 Structure Structure
TM2 91 V 2.66x65 Structure Structure
TM2 92 T 2.67x66 Structure Structure
TM2 93 G 2.68x67 Structure Structure
ECL1 94 G - Structure Structure
ECL1 95 V 23.49x49 Structure Structure
ECL1 96 W 23.50x50 Structure Structure
ECL1 97 N 23.51x51 Structure Structure
ECL1 98 F 23.52x52 Structure Structure
TM3 99 S 3.21x21 Structure Structure
TM3 100 R 3.22x22 Structure Structure
TM3 101 I 3.23x23 Structure Structure
TM3 102 C 3.24x24 Structure Structure
TM3 103 C 3.25x25 Structure Structure
TM3 104 D 3.26x26 Structure Structure
TM3 105 V 3.27x27 Structure Structure
TM3 106 F 3.28x28 Structure Structure
TM3 107 V 3.29x29 Structure Structure
TM3 108 T 3.30x30 Structure Structure
TM3 109 L 3.31x31 Structure Structure
TM3 110 D 3.32x32 Structure Structure
TM3 111 V 3.33x33 Structure Structure
TM3 112 M 3.34x34 Structure Structure
TM3 113 M 3.35x35 Structure Structure
TM3 114 C 3.36x36 Structure Structure
TM3 115 T 3.37x37 Structure Structure
TM3 116 A 3.38x38 Structure Structure
TM3 117 S 3.39x39 Structure Structure
TM3 118 I 3.40x40 Structure Structure
TM3 119 L 3.41x41 Structure Structure
TM3 120 N 3.42x42 Structure Structure
TM3 121 L 3.43x43 Structure Structure
TM3 122 C 3.44x44 Structure Structure
TM3 123 A 3.45x45 Structure Structure
TM3 124 I 3.46x46 Structure Structure
TM3 125 S 3.47x47 Structure Structure
TM3 126 I 3.48x48 Structure Structure
TM3 127 D 3.49x49 Structure Structure
TM3 128 R 3.50x50 Structure Structure
TM3 129 Y 3.51x51 Structure Structure
TM3 130 T 3.52x52 Structure Structure
TM3 131 A 3.53x53 Structure Structure
TM3 132 V 3.54x54 Structure Structure
TM3 133 V 3.55x55 Structure Structure
TM3 134 M 3.56x56 Structure Structure
ICL2 135 P 34.50x50 Structure Structure
ICL2 136 V 34.51x51 Structure Structure
ICL2 137 H 34.52x52 Structure Structure
ICL2 138 Y 34.53x53 Structure Structure
ICL2 139 Q 34.54x54 Structure Structure
ICL2 140 H 34.55x55 Structure Structure
ICL2 141 G 34.56x56 Structure Structure
ICL2 142 T 34.57x57 Structure Structure
ICL2 143 G 34.58x58 Structure Structure
ICL2 144 Q - Structure Structure
ICL2 145 S - Structure Structure
TM4 146 S 4.38x38 Structure Structure
TM4 147 C 4.39x39 Structure Structure
TM4 148 R 4.40x40 Structure Structure
TM4 149 R 4.41x41 Structure Structure
TM4 150 V 4.42x42 Structure Structure
TM4 151 A 4.43x43 Structure Structure
TM4 152 L 4.44x44 Structure Structure
TM4 153 M 4.45x45 Structure Structure
TM4 154 I 4.46x46 Structure Structure
TM4 155 T 4.47x47 Structure Structure
TM4 156 A 4.48x48 Structure Structure
TM4 157 V 4.49x49 Structure Structure
TM4 158 W 4.50x50 Structure Structure
TM4 159 V 4.51x51 Structure Structure
TM4 160 L 4.52x52 Structure Structure
TM4 161 A 4.53x53 Structure Structure
TM4 162 F 4.54x54 Structure Structure
TM4 163 A 4.55x55 Structure Structure
TM4 164 V 4.56x56 Structure Structure
TM4 165 S 4.57x57 Structure Structure
TM4 166 C 4.58x59 Structure Structure
TM4 167 P 4.59x60 Structure Structure
TM4 168 L 4.60x61 Structure Structure
TM4 169 L 4.61x62 Structure Structure
TM4 170 F 4.62x63 Structure Structure
TM4 171 G 4.63x64 Structure Structure
ECL2 172 F - Structure Structure
ECL2 173 N - Structure Structure
ECL2 174 T - Structure Structure
ECL2 175 T - Structure Structure
ECL2 176 G - Structure Structure
ECL2 177 D - Structure Structure
ECL2 178 P - Structure Structure
ECL2 179 T - Structure Structure
ECL2 180 V - Structure Structure
ECL2 181 C 45.50x50 Structure Structure
ECL2 182 S 45.51x51 Structure Structure
ECL2 183 I 45.52x52 Structure Structure
ECL2 184 S - Structure Structure
TM5 185 N 5.35x36 Structure Structure
TM5 186 P 5.36x37 Structure Structure
TM5 187 D 5.37x38 Structure Structure
TM5 188 F 5.38x39 Structure Structure
TM5 189 V 5.39x40 Structure Structure
TM5 190 I 5.40x41 Structure Structure
TM5 191 Y 5.41x42 Structure Structure
TM5 192 S 5.42x43 Structure Structure
TM5 193 S 5.43x44 Structure Structure
TM5 194 V 5.44x45 Structure Structure
TM5 195 V 5.45x46 Structure Structure
TM5 196 S 5.46x461 Structure Structure
TM5 197 F 5.47x47 Structure Structure
TM5 198 Y 5.48x48 Structure Structure
TM5 199 L 5.49x49 Structure Structure
TM5 200 P 5.50x50 Structure Structure
TM5 201 F 5.51x51 Structure Structure
TM5 202 G 5.52x52 Structure Structure
TM5 203 V 5.53x53 Structure Structure
TM5 204 T 5.54x54 Structure Structure
TM5 205 V 5.55x55 Structure Structure
TM5 206 L 5.56x56 Structure Structure
TM5 207 V 5.57x57 Structure Structure
TM5 208 Y 5.58x58 Structure Structure
TM5 209 A 5.59x59 Structure Structure
TM5 210 R 5.60x60 Structure Structure
TM5 211 I 5.61x61 Structure Structure
TM5 212 Y 5.62x62 Structure Structure
TM5 213 V 5.63x63 Structure Structure
TM5 214 V 5.64x64 Structure Structure
TM5 215 L 5.65x65 Structure Structure
TM5 216 K 5.66x66 Structure Structure
TM5 217 Q 5.67x67 Structure Structure
TM5 218 R 5.68x68 Structure Structure
TM5 219 R 5.69x69 Structure Structure
TM5 220 R 5.70x70 Structure Structure
TM5 221 K 5.71x71 Structure Structure
TM5 222 R 5.72x72 Structure Structure
TM5 223 I 5.73x73 Structure Structure
TM5 224 L 5.74x74 AF2 AF2
TM5 225 T 5.75x75 AF2 AF2
TM5 226 R 5.76x76 AF2 AF2
ICL3 227 Q - AF2 AF2
ICL3 228 N - AF2 AF2
ICL3 229 S - AF2 AF2
ICL3 230 Q - AF2 AF2
ICL3 231 C - AF2 AF2
ICL3 232 N - AF2 AF2
ICL3 233 S - AF2 AF2
ICL3 311 K - AF2 AF2
ICL3 312 L - AF2 AF2
ICL3 313 G - AF2 AF2
ICL3 314 P - AF2 AF2
ICL3 315 L - AF2 AF2
ICL3 316 Q - AF2 AF2
ICL3 317 P - AF2 AF2
TM6 318 R 6.24x24 AF2 AF2
TM6 319 G 6.25x25 AF2 AF2
TM6 320 V 6.26x26 AF2 AF2
TM6 321 P 6.27x27 Structure Structure
TM6 322 L 6.28x28 Structure Structure
TM6 323 R 6.29x29 Structure Structure
TM6 324 E 6.30x30 Structure Structure
TM6 325 K 6.31x31 Structure Structure
TM6 326 K 6.32x32 Structure Structure
TM6 327 A 6.33x33 Structure Structure
TM6 328 T 6.34x34 Structure Structure
TM6 329 Q 6.35x35 Structure Structure
TM6 330 M 6.36x36 Structure Structure
TM6 331 V 6.37x37 Structure Structure
TM6 332 A 6.38x38 Structure Structure
TM6 333 I 6.39x39 Structure Structure
TM6 334 V 6.40x40 Structure Structure
TM6 335 L 6.41x41 Structure Structure
TM6 336 G 6.42x42 Structure Structure
TM6 337 A 6.43x43 Structure Structure
TM6 338 F 6.44x44 Structure Structure
TM6 339 I 6.45x45 Structure Structure
TM6 340 V 6.46x46 Structure Structure
TM6 341 C 6.47x47 Structure Structure
TM6 342 W 6.48x48 Structure Structure
TM6 343 L 6.49x49 Structure Structure
TM6 344 P 6.50x50 Structure Structure
TM6 345 F 6.51x51 Structure Structure
TM6 346 F 6.52x52 Structure Structure
TM6 347 L 6.53x53 Structure Structure
TM6 348 T 6.54x54 Structure Structure
TM6 349 H 6.55x55 Structure Structure
TM6 350 V 6.56x56 Structure Structure
TM6 351 L 6.57x57 Structure Structure
TM6 352 N 6.58x58 Structure Structure
TM6 353 T 6.59x59 Structure Structure
TM6 354 H 6.60x60 Structure Structure
TM6 355 C 6.61x61 Structure Structure
ECL3 356 Q - Structure Structure
ECL3 357 T - Structure Structure
ECL3 358 C - Structure Structure
ECL3 359 H - Structure Structure
ECL3 360 V - Structure Structure
TM7 361 S 7.31x30 Structure Structure
TM7 362 P 7.32x31 Structure Structure
TM7 363 E 7.33x32 Structure Structure
TM7 364 L 7.34x33 Structure Structure
TM7 365 Y 7.35x34 Structure Structure
TM7 366 S 7.36x35 Structure Structure
TM7 367 A 7.37x36 Structure Structure
TM7 368 T 7.38x37 Structure Structure
TM7 369 T 7.39x38 Structure Structure
TM7 370 W 7.40x39 Structure Structure
TM7 371 L 7.41x40 Structure Structure
TM7 372 G 7.42x41 Structure Structure
TM7 373 Y 7.43x42 Structure Structure
TM7 374 V 7.44x43 Structure Structure
TM7 375 N 7.45x45 Structure Structure
TM7 376 S 7.46x46 Structure Structure
TM7 377 A 7.47x47 Structure Structure
TM7 378 L 7.48x48 Structure Structure
TM7 379 N 7.49x49 Structure Structure
TM7 380 P 7.50x50 Structure Structure
TM7 381 V 7.51x51 Structure Structure
TM7 382 I 7.52x52 Structure Structure
TM7 383 Y 7.53x53 Structure Structure
TM7 384 T 7.54x54 Structure Structure
TM7 385 T 7.55x55 Structure Structure
TM7 386 F 7.56x56 Structure Structure
H8 387 N 8.47x47 Structure Structure
H8 388 I 8.48x48 Structure Structure
H8 389 E 8.49x49 Structure Structure
H8 390 F 8.50x50 Structure Structure
H8 391 R 8.51x51 Structure Structure
H8 392 K 8.52x52 Structure Structure
H8 393 A 8.53x53 Structure Structure
H8 394 F 8.54x54 Structure Structure
H8 395 L 8.55x55 Structure Structure
H8 396 K 8.56x56 Structure Structure
H8 397 I 8.57x57 Structure Structure
H8 398 L 8.58x58 Structure Structure
H8 399 S 8.59x59 Structure Structure
C-term 400 C - Structure Structure



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 132 3x54 G.H5 L 348 G.H5.20
Polar ICL2 Y 138 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 138 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 138 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 131 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 131 3x53 G.H5 C 351 G.H5.23
Aromatic TM6 R 323 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 323 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 323 6x29 G.H5 F 354 G.H5.26
Polar TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 323 6x29 G.h4s6 D 315 G.h4s6.09
Ionic TM5 R 222 5x72 G.H5 D 341 G.H5.13
Polar TM5 R 222 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 222 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 222 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 215 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 135 34x50 G.H5 I 343 G.H5.15
Polar ICL2 Q 144 - G.HN E 28 G.HN.52
Hydrophobic ICL2 Q 144 - G.HN E 28 G.HN.52
Van-der-waals ICL2 Q 144 - G.HN E 28 G.HN.52
Polar ICL3 S 233 - G.H4 E 298 G.H4.05
Hydrophobic ICL3 S 233 - G.H4 E 298 G.H4.05
Van-der-waals ICL3 S 233 - G.H4 E 298 G.H4.05
Polar TM6 R 318 6x24 G.H4 C 305 G.H4.13
Hydrophobic TM6 R 318 6x24 G.H4 C 305 G.H4.13
Van-der-waals TM6 R 318 6x24 G.H4 C 305 G.H4.13
Van-der-waals TM6 R 323 6x29 G.H5 K 349 G.H5.21
Hydrophobic TM6 A 327 6x33 G.H5 L 353 G.H5.25
Polar TM3 A 131 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 131 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM2 T 64 2x39 G.H5 C 351 G.H5.23
Polar ICL2 H 140 34x55 G.H5 D 350 G.H5.22
Hydrophobic TM6 M 330 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 222 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 222 5x72 G.S6 Y 320 G.S6.02
Polar ICL3 C 231 - G.H4 E 297 G.H4.04
Hydrophobic ICL3 C 231 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 C 231 - G.H4 E 297 G.H4.04
Hydrophobic TM6 E 324 6x30 G.H5 F 354 G.H5.26
Polar ICL2 P 135 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 135 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 135 34x50 G.H5 N 347 G.H5.19
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 341 G.H5.13
Polar TM6 R 323 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL2 V 136 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 V 331 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 135 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 135 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 128 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 128 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 136 34x51 G.S3 L 194 G.S3.01
Polar TM6 K 326 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 326 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 Y 138 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 327 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 327 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 C 231 - G.H4 A 301 G.H4.08
Van-der-waals ICL3 C 231 - G.H4 A 301 G.H4.08
Hydrophobic ICL2 Q 139 34x54 G.H5 I 343 G.H5.15
Polar TM3 R 128 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 128 3x50 G.H5 C 351 G.H5.23
Polar ICL2 Q 139 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 139 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Q 139 34x54 G.H5 N 347 G.H5.19