Refined structure (7DFL) of Gq - H1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (62.7%), 134 from model (37.3%)
Residue sidechains - 208 from structure (57.9%), 151 from model (42.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 Structure Structure
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure Structure
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure Structure
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure Structure
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure Structure
G.s1h1 48 G G.s1h1.03 Structure Structure
G.s1h1 49 E G.s1h1.04 Structure Structure
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure Structure
G.H1 56 I G.H1.05 Structure Structure
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 Structure Structure
G.H1 63 H G.H1.12 Structure Structure
G.h1ha 64 G G.h1ha.01 Structure Structure
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 AF2 AF2
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure Structure
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure Structure
G.S2 193 P G.S2.05 Structure Structure
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure Structure
G.S2 196 L G.S2.08 Structure Structure
G.s2s3 197 Q G.s2s3.01 Structure Structure
G.s2s3 198 S G.s2s3.02 Structure Structure
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure Structure
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure Structure
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure Structure
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure Structure
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure Structure
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure Structure
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure Structure
G.h2s4 222 N G.h2s4.03 Structure Structure
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure Structure
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure Structure
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure Structure
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure Structure
G.s4h3 232 L G.s4h3.01 Structure Structure
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure Structure
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure Structure
G.s4h3 237 Q G.s4h3.06 Structure Structure
G.s4h3 238 V G.s4h3.07 Structure Structure
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 Structure Structure
G.s4h3 244 N G.s4h3.13 Structure Structure
G.s4h3 245 E G.s4h3.14 Structure Structure
G.s4h3 246 N G.s4h3.15 Structure Structure
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure Structure
G.H3 249 E G.H3.03 Structure Structure
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure Structure
G.H3 252 K G.H3.06 Structure Structure
G.H3 253 A G.H3.07 Structure Structure
G.H3 254 L G.H3.08 Structure Structure
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure Structure
G.H3 257 T G.H3.11 Structure Structure
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure Structure
G.H3 260 T G.H3.14 Structure Structure
G.H3 261 Y G.H3.15 Structure Structure
G.H3 262 P G.H3.16 Structure Structure
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure Structure
G.h3s5 265 Q G.h3s5.01 Structure Structure
G.h3s5 266 N G.h3s5.02 Structure Structure
G.h3s5 267 S G.h3s5.03 Structure Structure
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure Structure
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure Structure
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure Structure
G.HG 284 M G.HG.09 Structure Structure
G.HG 285 Y G.HG.12 Structure Structure
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure Structure
G.HG 288 L G.HG.15 Structure Structure
G.HG 289 V G.HG.16 Structure Structure
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure Structure
G.hgh4 295 Y G.hgh4.05 Structure Structure
G.hgh4 296 D G.hgh4.06 Structure Structure
G.hgh4 297 G G.hgh4.07 Structure Structure
G.hgh4 298 P G.hgh4.08 Structure Structure
G.H4 299 Q G.H4.01 Structure Structure
G.H4 300 R G.H4.02 Structure Structure
G.H4 301 D G.H4.03 Structure Structure
G.H4 302 A G.H4.04 Structure Structure
G.H4 303 Q G.H4.05 Structure Structure
G.H4 304 A G.H4.06 Structure Structure
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure Structure
G.H4 307 E G.H4.09 Structure Structure
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure Structure
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure Structure
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure Structure
G.h4s6 317 N G.h4s6.08 Structure Structure
G.h4s6 318 P G.h4s6.09 Structure Structure
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure Structure
G.h4s6 321 D G.h4s6.12 Structure Structure
G.h4s6 322 K G.h4s6.13 Structure Structure
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure Structure
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure Structure
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure Structure
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure Structure
G.H5 340 V G.H5.07 Structure Structure
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure Structure
G.H5 343 A G.H5.10 Structure Structure
G.H5 344 V G.H5.11 Structure Structure
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure Structure
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure Structure
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure Structure
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 274 from structure (84.0%), 52 from model (16.0%)
Residue sidechains - 274 from structure (84.0%), 52 from model (16.0%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 L - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 C - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 D - AF2 AF2
N-term 13 K - AF2 AF2
N-term 14 M - AF2 AF2
N-term 15 C - AF2 AF2
N-term 16 E - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 K - AF2 AF2
N-term 20 T - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 M - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 S - AF2 AF2
N-term 25 P - AF2 AF2
N-term 26 Q - AF2 AF2
N-term 27 L - AF2 AF2
N-term 28 M - AF2 AF2
TM1 29 P 1.34x34 Structure Structure
TM1 30 L 1.35x35 Structure Structure
TM1 31 V 1.36x36 Structure Structure
TM1 32 V 1.37x37 Structure Structure
TM1 33 V 1.38x38 Structure Structure
TM1 34 L 1.39x39 Structure Structure
TM1 35 S 1.40x40 Structure Structure
TM1 36 T 1.41x41 Structure Structure
TM1 37 I 1.42x42 Structure Structure
TM1 38 C 1.43x43 Structure Structure
TM1 39 L 1.44x44 Structure Structure
TM1 40 V 1.45x45 Structure Structure
TM1 41 T 1.46x46 Structure Structure
TM1 42 V 1.47x47 Structure Structure
TM1 43 G 1.48x48 Structure Structure
TM1 44 L 1.49x49 Structure Structure
TM1 45 N 1.50x50 Structure Structure
TM1 46 L 1.51x51 Structure Structure
TM1 47 L 1.52x52 Structure Structure
TM1 48 V 1.53x53 Structure Structure
TM1 49 L 1.54x54 Structure Structure
TM1 50 Y 1.55x55 Structure Structure
TM1 51 A 1.56x56 Structure Structure
TM1 52 V 1.57x57 Structure Structure
TM1 53 R 1.58x58 Structure Structure
TM1 54 S 1.59x59 Structure Structure
TM1 55 E 1.60x60 Structure Structure
ICL1 56 R 12.48x48 Structure Structure
ICL1 57 K 12.49x49 Structure Structure
ICL1 58 L 12.50x50 Structure Structure
ICL1 59 H 12.51x51 Structure Structure
TM2 60 T 2.37x37 Structure Structure
TM2 61 V 2.38x38 Structure Structure
TM2 62 G 2.39x39 Structure Structure
TM2 63 N 2.40x40 Structure Structure
TM2 64 L 2.41x41 Structure Structure
TM2 65 Y 2.42x42 Structure Structure
TM2 66 I 2.43x43 Structure Structure
TM2 67 V 2.44x44 Structure Structure
TM2 68 S 2.45x45 Structure Structure
TM2 69 L 2.46x46 Structure Structure
TM2 70 S 2.47x47 Structure Structure
TM2 71 V 2.48x48 Structure Structure
TM2 72 A 2.49x49 Structure Structure
TM2 73 D 2.50x50 Structure Structure
TM2 74 L 2.51x51 Structure Structure
TM2 75 I 2.52x52 Structure Structure
TM2 76 V 2.53x53 Structure Structure
TM2 77 G 2.54x54 Structure Structure
TM2 78 A 2.55x55 Structure Structure
TM2 79 V 2.56x551 Structure Structure
TM2 80 V 2.57x56 Structure Structure
TM2 81 M 2.58x57 Structure Structure
TM2 82 P 2.59x58 Structure Structure
TM2 83 M 2.60x59 Structure Structure
TM2 84 N 2.61x60 Structure Structure
TM2 85 I 2.62x61 Structure Structure
TM2 86 L 2.63x62 Structure Structure
TM2 87 Y 2.64x63 Structure Structure
TM2 88 L 2.65x64 Structure Structure
TM2 89 L 2.66x65 Structure Structure
TM2 90 M 2.67x66 Structure Structure
ECL1 91 S - Structure Structure
ECL1 92 K 23.49x49 Structure Structure
ECL1 93 W 23.50x50 Structure Structure
ECL1 94 S 23.51x51 Structure Structure
ECL1 95 L 23.52x52 Structure Structure
TM3 96 G 3.21x21 Structure Structure
TM3 97 R 3.22x22 Structure Structure
TM3 98 P 3.23x23 Structure Structure
TM3 99 L 3.24x24 Structure Structure
TM3 100 C 3.25x25 Structure Structure
TM3 101 L 3.26x26 Structure Structure
TM3 102 F 3.27x27 Structure Structure
TM3 103 W 3.28x28 Structure Structure
TM3 104 L 3.29x29 Structure Structure
TM3 105 S 3.30x30 Structure Structure
TM3 106 M 3.31x31 Structure Structure
TM3 107 D 3.32x32 Structure Structure
TM3 108 Y 3.33x33 Structure Structure
TM3 109 V 3.34x34 Structure Structure
TM3 110 A 3.35x35 Structure Structure
TM3 111 S 3.36x36 Structure Structure
TM3 112 T 3.37x37 Structure Structure
TM3 113 A 3.38x38 Structure Structure
TM3 114 S 3.39x39 Structure Structure
TM3 115 I 3.40x40 Structure Structure
TM3 116 F 3.41x41 Structure Structure
TM3 117 S 3.42x42 Structure Structure
TM3 118 V 3.43x43 Structure Structure
TM3 119 F 3.44x44 Structure Structure
TM3 120 I 3.45x45 Structure Structure
TM3 121 L 3.46x46 Structure Structure
TM3 122 C 3.47x47 Structure Structure
TM3 123 I 3.48x48 Structure Structure
TM3 124 D 3.49x49 Structure Structure
TM3 125 R 3.50x50 Structure Structure
TM3 126 Y 3.51x51 Structure Structure
TM3 127 R 3.52x52 Structure Structure
TM3 128 S 3.53x53 Structure Structure
TM3 129 V 3.54x54 Structure Structure
TM3 130 Q 3.55x55 Structure Structure
TM3 131 Q 3.56x56 Structure Structure
ICL2 132 P 34.50x50 Structure Structure
ICL2 133 L 34.51x51 Structure Structure
ICL2 134 R 34.52x52 Structure Structure
ICL2 135 Y 34.53x53 Structure Structure
ICL2 136 L 34.54x54 Structure Structure
ICL2 137 K 34.55x55 Structure Structure
ICL2 138 Y 34.56x56 Structure Structure
ICL2 139 R 34.57x57 Structure Structure
TM4 140 T 4.38x38 Structure Structure
TM4 141 K 4.39x39 Structure Structure
TM4 142 T 4.40x40 Structure Structure
TM4 143 R 4.41x41 Structure Structure
TM4 144 A 4.42x42 Structure Structure
TM4 145 S 4.43x43 Structure Structure
TM4 146 A 4.44x44 Structure Structure
TM4 147 T 4.45x45 Structure Structure
TM4 148 I 4.46x46 Structure Structure
TM4 149 L 4.47x47 Structure Structure
TM4 150 G 4.48x48 Structure Structure
TM4 151 A 4.49x49 Structure Structure
TM4 152 W 4.50x50 Structure Structure
TM4 153 F 4.51x51 Structure Structure
TM4 154 L 4.52x52 Structure Structure
TM4 155 S 4.53x53 Structure Structure
TM4 156 F 4.54x54 Structure Structure
TM4 157 L 4.55x55 Structure Structure
TM4 158 W 4.56x57 Structure Structure
TM4 159 V 4.57x58 Structure Structure
TM4 160 I 4.58x59 Structure Structure
TM4 161 P 4.59x60 Structure Structure
TM4 162 I 4.60x61 Structure Structure
TM4 163 L 4.61x62 Structure Structure
TM4 164 G 4.62x63 Structure Structure
ECL2 165 W - Structure Structure
ECL2 166 N - Structure Structure
ECL2 167 H - Structure Structure
ECL2 168 F - Structure Structure
ECL2 169 M - Structure Structure
ECL2 170 Q - Structure Structure
ECL2 171 Q - Structure Structure
ECL2 172 T - Structure Structure
ECL2 173 S - Structure Structure
ECL2 174 V - Structure Structure
ECL2 175 R - Structure Structure
ECL2 176 R - Structure Structure
ECL2 177 E - Structure Structure
ECL2 178 D - Structure Structure
ECL2 179 K - Structure Structure
ECL2 180 C 45.50x50 Structure Structure
ECL2 181 E 45.51x51 Structure Structure
ECL2 182 T 45.52x52 Structure Structure
ECL2 183 D - Structure Structure
ECL2 184 F - Structure Structure
ECL2 185 Y - Structure Structure
ECL2 186 D - Structure Structure
TM5 187 V 5.35x36 Structure Structure
TM5 188 T 5.36x37 Structure Structure
TM5 189 W 5.37x38 Structure Structure
TM5 190 F 5.38x39 Structure Structure
TM5 191 K 5.39x40 Structure Structure
TM5 192 V 5.40x41 Structure Structure
TM5 193 M 5.41x42 Structure Structure
TM5 194 T 5.42x43 Structure Structure
TM5 195 A 5.43x44 Structure Structure
TM5 196 I 5.44x45 Structure Structure
TM5 197 I 5.45x46 Structure Structure
TM5 198 N 5.46x461 Structure Structure
TM5 199 F 5.47x47 Structure Structure
TM5 200 Y 5.48x48 Structure Structure
TM5 201 L 5.49x49 Structure Structure
TM5 202 P 5.50x50 Structure Structure
TM5 203 T 5.51x51 Structure Structure
TM5 204 L 5.52x52 Structure Structure
TM5 205 L 5.53x53 Structure Structure
TM5 206 M 5.54x54 Structure Structure
TM5 207 L 5.55x55 Structure Structure
TM5 208 W 5.56x56 Structure Structure
TM5 209 F 5.57x57 Structure Structure
TM5 210 Y 5.58x58 Structure Structure
TM5 211 A 5.59x59 Structure Structure
TM5 212 K 5.60x60 Structure Structure
TM5 213 I 5.61x61 Structure Structure
TM5 214 Y 5.62x62 Structure Structure
TM5 215 K 5.63x63 Structure Structure
TM5 216 A 5.64x64 Structure Structure
TM5 217 V 5.65x65 Structure Structure
TM5 218 R 5.66x66 Structure Structure
TM5 219 Q 5.67x67 Structure Structure
TM5 220 H 5.68x68 Structure Structure
TM5 221 C 5.69x69 Structure Structure
TM5 222 Q 5.70x70 AF2 AF2
TM5 223 H 5.71x71 AF2 AF2
TM5 224 R 5.72x72 AF2 AF2
TM5 225 E 5.73x73 AF2 AF2
TM5 226 L 5.74x74 AF2 AF2
TM5 227 I 5.75x75 AF2 AF2
TM5 228 N 5.76x76 AF2 AF2
ICL3 229 R - AF2 AF2
ICL3 230 S - AF2 AF2
ICL3 231 L - AF2 AF2
ICL3 232 P - AF2 AF2
ICL3 233 S - AF2 AF2
ICL3 234 F - AF2 AF2
ICL3 235 S - AF2 AF2
ICL3 397 H - AF2 AF2
ICL3 398 S - AF2 AF2
ICL3 399 R - AF2 AF2
ICL3 400 Q - AF2 AF2
ICL3 401 Y - AF2 AF2
ICL3 402 V - AF2 AF2
ICL3 403 S - AF2 AF2
TM6 404 G 6.24x24 AF2 AF2
TM6 405 L 6.25x25 Structure Structure
TM6 406 H 6.26x26 Structure Structure
TM6 407 M 6.27x27 Structure Structure
TM6 408 N 6.28x28 Structure Structure
TM6 409 R 6.29x29 Structure Structure
TM6 410 E 6.30x30 Structure Structure
TM6 411 R 6.31x31 Structure Structure
TM6 412 K 6.32x32 Structure Structure
TM6 413 A 6.33x33 Structure Structure
TM6 414 A 6.34x34 Structure Structure
TM6 415 K 6.35x35 Structure Structure
TM6 416 Q 6.36x36 Structure Structure
TM6 417 L 6.37x37 Structure Structure
TM6 418 G 6.38x38 Structure Structure
TM6 419 F 6.39x39 Structure Structure
TM6 420 I 6.40x40 Structure Structure
TM6 421 M 6.41x41 Structure Structure
TM6 422 A 6.42x42 Structure Structure
TM6 423 A 6.43x43 Structure Structure
TM6 424 F 6.44x44 Structure Structure
TM6 425 I 6.45x45 Structure Structure
TM6 426 L 6.46x46 Structure Structure
TM6 427 C 6.47x47 Structure Structure
TM6 428 W 6.48x48 Structure Structure
TM6 429 I 6.49x49 Structure Structure
TM6 430 P 6.50x50 Structure Structure
TM6 431 Y 6.51x51 Structure Structure
TM6 432 F 6.52x52 Structure Structure
TM6 433 I 6.53x53 Structure Structure
TM6 434 F 6.54x54 Structure Structure
TM6 435 F 6.55x55 Structure Structure
TM6 436 M 6.56x56 Structure Structure
TM6 437 V 6.57x57 Structure Structure
TM6 438 I 6.58x58 Structure Structure
TM6 439 A 6.59x59 Structure Structure
TM6 440 F 6.60x60 Structure Structure
TM6 441 C 6.61x61 Structure Structure
ECL3 442 K - Structure Structure
ECL3 443 N - Structure Structure
ECL3 444 C - Structure Structure
ECL3 445 C - Structure Structure
TM7 446 N 7.31x30 Structure Structure
TM7 447 E 7.32x31 Structure Structure
TM7 448 H 7.33x32 Structure Structure
TM7 449 L 7.34x33 Structure Structure
TM7 450 H 7.35x34 Structure Structure
TM7 451 M 7.36x35 Structure Structure
TM7 452 F 7.37x36 Structure Structure
TM7 453 T 7.38x37 Structure Structure
TM7 454 I 7.39x38 Structure Structure
TM7 455 W 7.40x39 Structure Structure
TM7 456 L 7.41x40 Structure Structure
TM7 457 G 7.42x41 Structure Structure
TM7 458 Y 7.43x42 Structure Structure
TM7 459 I 7.44x43 Structure Structure
TM7 460 N 7.45x45 Structure Structure
TM7 461 S 7.46x46 Structure Structure
TM7 462 T 7.47x47 Structure Structure
TM7 463 L 7.48x48 Structure Structure
TM7 464 N 7.49x49 Structure Structure
TM7 465 P 7.50x50 Structure Structure
TM7 466 L 7.51x51 Structure Structure
TM7 467 I 7.52x52 Structure Structure
TM7 468 Y 7.53x53 Structure Structure
TM7 469 P 7.54x54 Structure Structure
TM7 470 L 7.55x55 Structure Structure
TM7 471 C 7.56x56 Structure Structure
H8 472 N 8.47x47 Structure Structure
H8 473 E 8.48x48 Structure Structure
H8 474 N 8.49x49 Structure Structure
H8 475 F 8.50x50 Structure Structure
H8 476 K 8.51x51 Structure Structure
H8 477 K 8.52x52 Structure Structure
H8 478 T 8.53x53 Structure Structure
H8 479 F 8.54x54 Structure Structure
H8 480 K 8.55x55 Structure Structure
H8 481 R 8.56x56 Structure Structure
H8 482 I 8.57x57 Structure Structure
H8 483 L 8.58x58 Structure Structure
H8 484 H 8.59x59 Structure Structure
C-term 485 I - Structure Structure
C-term 486 R - AF2 AF2
C-term 487 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 P 232 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 P 232 - G.H4 V 314 G.H4.16
Hydrophobic TM5 R 224 5x72 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM5 R 224 5x72 G.h4s6 I 323 G.h4s6.20
Polar H8 N 474 8x49 G.H5 N 357 G.H5.24
Hydrophobic ICL3 P 232 - G.H4 L 310 G.H4.12
Hydrophobic TM7 C 471 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 C 471 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM5 H 220 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 H 220 5x68 G.H5 L 349 G.H5.16
Hydrophobic ICL3 F 234 - G.H4 K 311 G.H4.13
Van-der-waals ICL3 F 234 - G.H4 K 311 G.H4.13
Polar ICL2 Y 135 34x53 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 Y 135 34x53 G.hns1 R 38 G.hns1.03
Polar TM6 K 412 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM3 V 129 3x54 G.H5 L 349 G.H5.16
Polar TM6 A 413 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 413 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL3 P 232 - G.H4 D 315 G.H4.17
Van-der-waals ICL3 P 232 - G.H4 D 315 G.H4.17
Hydrophobic ICL3 S 233 - G.H4 K 311 G.H4.13
Van-der-waals ICL3 S 233 - G.H4 K 311 G.H4.13
Van-der-waals H8 N 472 8x47 G.H5 Y 356 G.H5.23
Van-der-waals TM6 R 409 6x29 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 132 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 132 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM5 I 227 5x75 G.S6 I 324 G.S6.01
Van-der-waals TM5 I 227 5x75 G.S6 I 324 G.S6.01
Polar H8 N 472 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 472 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL3 L 231 - G.H4 K 311 G.H4.13
Van-der-waals ICL2 K 137 34x55 G.hns1 R 38 G.hns1.03
Ionic TM5 H 220 5x68 G.H5 D 346 G.H5.13
Polar TM5 H 220 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM5 H 220 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 H 220 5x68 G.H5 D 346 G.H5.13
Polar TM5 H 220 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 H 220 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM6 Q 416 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL2 Y 135 34x53 G.S3 V 199 G.S3.01
Hydrophobic ICL2 L 133 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 133 34x51 G.H5 I 348 G.H5.15
Polar TM5 R 224 5x72 G.H5 Q 350 G.H5.17
Hydrophobic TM5 R 224 5x72 G.H5 Q 350 G.H5.17
Van-der-waals TM5 R 224 5x72 G.H5 Q 350 G.H5.17
Hydrophobic ICL3 L 231 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 L 231 - G.H4 V 314 G.H4.16
Hydrophobic TM6 L 417 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 K 137 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 K 137 34x55 G.hns1 R 37 G.hns1.02
Polar ICL2 K 137 34x55 G.HN R 34 G.HN.52
Hydrophobic ICL2 K 137 34x55 G.HN R 34 G.HN.52
Van-der-waals ICL2 K 137 34x55 G.HN R 34 G.HN.52
Aromatic TM3 R 125 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 133 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM6 L 405 6x25 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 L 405 6x25 G.h4s6 D 321 G.h4s6.12
Ionic TM5 H 223 5x71 G.H5 D 346 G.H5.13
Polar TM5 H 223 5x71 G.H5 D 346 G.H5.13
Hydrophobic TM5 H 223 5x71 G.H5 D 346 G.H5.13
Van-der-waals TM5 H 223 5x71 G.H5 D 346 G.H5.13
Hydrophobic TM6 K 412 6x32 G.H5 L 358 G.H5.25
Hydrophobic TM5 I 227 5x75 G.S6 Y 325 G.S6.02
Van-der-waals TM5 I 227 5x75 G.S6 Y 325 G.S6.02
Hydrophobic ICL2 L 136 34x54 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 L 136 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic ICL3 S 230 - G.H4 L 310 G.H4.12
Hydrophobic ICL2 P 132 34x50 G.H5 F 341 G.H5.08
Hydrophobic TM5 V 217 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 V 217 5x65 G.H5 L 353 G.H5.20
Hydrophobic ICL3 L 231 - G.H4 L 310 G.H4.12
Polar ICL3 P 232 - G.H4 K 311 G.H4.13
Hydrophobic ICL3 P 232 - G.H4 K 311 G.H4.13
Van-der-waals ICL3 P 232 - G.H4 K 311 G.H4.13
Polar TM3 S 128 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 128 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 128 3x53 G.H5 N 352 G.H5.19
Polar TM3 D 124 3x49 G.H5 Y 356 G.H5.23
Polar ICL3 S 230 - G.S6 S 326 G.S6.03
Hydrophobic ICL2 Y 135 34x53 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 Y 135 34x53 G.s2s3 S 198 G.s2s3.02
Polar TM3 S 128 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 S 128 3x53 G.H5 Y 356 G.H5.23
Van-der-waals H8 N 472 8x47 G.H5 E 355 G.H5.22
Polar TM6 K 412 6x32 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 412 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM3 V 129 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 353 G.H5.20
Ionic ICL2 R 139 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 139 34x57 G.H5 E 355 G.H5.22
Hydrophobic ICL3 F 234 - G.hgh4 D 296 G.hgh4.06
Polar ICL3 S 235 - G.H4 D 315 G.H4.17
Hydrophobic ICL3 S 235 - G.H4 D 315 G.H4.17
Van-der-waals ICL3 S 235 - G.H4 D 315 G.H4.17