Refined structure (7EJA) of Go - α2A-adrenoceptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 210 from structure (59.3%), 144 from model (40.7%)
Residue sidechains - 203 from structure (57.3%), 151 from model (42.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 E G.HN.33 Structure Structure
G.HN 10 R G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 A G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 Structure Structure
G.hfs2 182 T G.hfs2.05 Structure Structure
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure AF2
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 N G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure Structure
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure AF2
G.H2 209 R G.H2.04 Structure AF2
G.H2 210 K G.H2.05 Structure AF2
G.H2 211 K G.H2.06 Structure AF2
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure AF2
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 D G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure Structure
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 AF2 AF2
G.s4h3 230 G G.s4h3.03 AF2 AF2
G.s4h3 231 Y G.s4h3.04 AF2 AF2
G.s4h3 232 D G.s4h3.05 AF2 AF2
G.s4h3 233 Q G.s4h3.06 AF2 AF2
G.s4h3 234 V G.s4h3.07 AF2 AF2
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 H G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 T G.s4h3.13 AF2 AF2
G.s4h3 241 T G.s4h3.14 AF2 AF2
G.s4h3 242 N G.s4h3.15 AF2 AF2
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure Structure
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure Structure
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure Structure
G.HG 281 K G.HG.12 Structure Structure
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure Structure
G.hgh4 291 Y G.hgh4.05 Structure Structure
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 T G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure Structure
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure Structure
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 A G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure AF2
G.H5 350 G G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 265 from structure (75.7%), 85 from model (24.3%)
Residue sidechains - 265 from structure (75.7%), 85 from model (24.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 F - AF2 AF2
N-term 3 R - AF2 AF2
N-term 4 Q - AF2 AF2
N-term 5 E - AF2 AF2
N-term 6 Q - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 E - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 F - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 P - AF2 AF2
N-term 16 M - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 S - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 Q - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 D - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 N - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 W - AF2 AF2
N-term 29 N - AF2 AF2
N-term 30 G - AF2 AF2
N-term 31 T - AF2 AF2
N-term 32 E - AF2 AF2
N-term 33 A - AF2 AF2
N-term 34 P - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 G - AF2 AF2
N-term 37 G - AF2 AF2
N-term 38 A - AF2 AF2
N-term 39 R - AF2 AF2
N-term 40 A - AF2 AF2
N-term 41 T - AF2 AF2
N-term 42 P - AF2 AF2
N-term 43 Y - AF2 AF2
N-term 44 S - AF2 AF2
N-term 45 L - AF2 AF2
TM1 46 Q 1.30x30 AF2 AF2
TM1 47 V 1.31x31 Structure Structure
TM1 48 T 1.32x32 Structure Structure
TM1 49 L 1.33x33 Structure Structure
TM1 50 T 1.34x34 Structure Structure
TM1 51 L 1.35x35 Structure Structure
TM1 52 V 1.36x36 Structure Structure
TM1 53 C 1.37x37 Structure Structure
TM1 54 L 1.38x38 Structure Structure
TM1 55 A 1.39x39 Structure Structure
TM1 56 G 1.40x40 Structure Structure
TM1 57 L 1.41x41 Structure Structure
TM1 58 L 1.42x42 Structure Structure
TM1 59 M 1.43x43 Structure Structure
TM1 60 L 1.44x44 Structure Structure
TM1 61 L 1.45x45 Structure Structure
TM1 62 T 1.46x46 Structure Structure
TM1 63 V 1.47x47 Structure Structure
TM1 64 F 1.48x48 Structure Structure
TM1 65 G 1.49x49 Structure Structure
TM1 66 N 1.50x50 Structure Structure
TM1 67 V 1.51x51 Structure Structure
TM1 68 L 1.52x52 Structure Structure
TM1 69 V 1.53x53 Structure Structure
TM1 70 I 1.54x54 Structure Structure
TM1 71 I 1.55x55 Structure Structure
TM1 72 A 1.56x56 Structure Structure
TM1 73 V 1.57x57 Structure Structure
TM1 74 F 1.58x58 Structure Structure
TM1 75 T 1.59x59 Structure Structure
TM1 76 S 1.60x60 Structure Structure
ICL1 77 R 12.48x48 Structure Structure
ICL1 78 A 12.49x49 Structure Structure
ICL1 79 L 12.50x50 Structure Structure
ICL1 80 K 12.51x51 Structure Structure
TM2 81 A 2.37x37 Structure Structure
TM2 82 P 2.38x38 Structure Structure
TM2 83 Q 2.39x39 Structure Structure
TM2 84 N 2.40x40 Structure Structure
TM2 85 L 2.41x41 Structure Structure
TM2 86 F 2.42x42 Structure Structure
TM2 87 L 2.43x43 Structure Structure
TM2 88 V 2.44x44 Structure Structure
TM2 89 S 2.45x45 Structure Structure
TM2 90 L 2.46x46 Structure Structure
TM2 91 A 2.47x47 Structure Structure
TM2 92 S 2.48x48 Structure Structure
TM2 93 A 2.49x49 Structure Structure
TM2 94 D 2.50x50 Structure Structure
TM2 95 I 2.51x51 Structure Structure
TM2 96 L 2.52x52 Structure Structure
TM2 97 V 2.53x53 Structure Structure
TM2 98 A 2.54x54 Structure Structure
TM2 99 T 2.55x55 Structure Structure
TM2 100 L 2.56x551 Structure Structure
TM2 101 V 2.57x56 Structure Structure
TM2 102 I 2.58x57 Structure Structure
TM2 103 P 2.59x58 Structure Structure
TM2 104 F 2.60x59 Structure Structure
TM2 105 S 2.61x60 Structure Structure
TM2 106 L 2.62x61 Structure Structure
TM2 107 A 2.63x62 Structure Structure
TM2 108 N 2.64x63 Structure Structure
TM2 109 E 2.65x64 Structure Structure
TM2 110 V 2.66x65 Structure Structure
TM2 111 M 2.67x66 Structure Structure
TM2 112 G 2.68x67 Structure Structure
ECL1 113 Y 23.49x49 Structure Structure
ECL1 114 W 23.50x50 Structure Structure
ECL1 115 Y 23.51x51 Structure Structure
ECL1 116 F 23.52x52 Structure Structure
TM3 117 G 3.21x21 Structure Structure
TM3 118 K 3.22x22 Structure Structure
TM3 119 A 3.23x23 Structure Structure
TM3 120 W 3.24x24 Structure Structure
TM3 121 C 3.25x25 Structure Structure
TM3 122 E 3.26x26 Structure Structure
TM3 123 I 3.27x27 Structure Structure
TM3 124 Y 3.28x28 Structure Structure
TM3 125 L 3.29x29 Structure Structure
TM3 126 A 3.30x30 Structure Structure
TM3 127 L 3.31x31 Structure Structure
TM3 128 D 3.32x32 Structure Structure
TM3 129 V 3.33x33 Structure Structure
TM3 130 L 3.34x34 Structure Structure
TM3 131 F 3.35x35 Structure Structure
TM3 132 C 3.36x36 Structure Structure
TM3 133 T 3.37x37 Structure Structure
TM3 134 S 3.38x38 Structure Structure
TM3 135 S 3.39x39 Structure Structure
TM3 136 I 3.40x40 Structure Structure
TM3 137 V 3.41x41 Structure Structure
TM3 138 H 3.42x42 Structure Structure
TM3 139 L 3.43x43 Structure Structure
TM3 140 C 3.44x44 Structure Structure
TM3 141 A 3.45x45 Structure Structure
TM3 142 I 3.46x46 Structure Structure
TM3 143 S 3.47x47 Structure Structure
TM3 144 L 3.48x48 Structure Structure
TM3 145 D 3.49x49 Structure Structure
TM3 146 R 3.50x50 Structure Structure
TM3 147 Y 3.51x51 Structure Structure
TM3 148 W 3.52x52 Structure Structure
TM3 149 S 3.53x53 Structure Structure
TM3 150 I 3.54x54 Structure Structure
TM3 151 T 3.55x55 Structure Structure
TM3 152 Q 3.56x56 Structure Structure
ICL2 153 A 34.50x50 Structure Structure
ICL2 154 I 34.51x51 Structure Structure
ICL2 155 E 34.52x52 Structure Structure
ICL2 156 Y 34.53x53 Structure Structure
ICL2 157 N 34.54x54 Structure Structure
ICL2 158 L 34.55x55 Structure Structure
ICL2 159 K 34.56x56 Structure Structure
ICL2 160 R 34.57x57 Structure Structure
TM4 161 T 4.38x38 Structure Structure
TM4 162 P 4.39x39 Structure Structure
TM4 163 R 4.40x40 Structure Structure
TM4 164 R 4.41x41 Structure Structure
TM4 165 I 4.42x42 Structure Structure
TM4 166 K 4.43x43 Structure Structure
TM4 167 A 4.44x44 Structure Structure
TM4 168 I 4.45x45 Structure Structure
TM4 169 I 4.46x46 Structure Structure
TM4 170 I 4.47x47 Structure Structure
TM4 171 T 4.48x48 Structure Structure
TM4 172 V 4.49x49 Structure Structure
TM4 173 W 4.50x50 Structure Structure
TM4 174 V 4.51x51 Structure Structure
TM4 175 I 4.52x52 Structure Structure
TM4 176 S 4.53x53 Structure Structure
TM4 177 A 4.54x54 Structure Structure
TM4 178 V 4.55x55 Structure Structure
TM4 179 I 4.56x56 Structure Structure
TM4 180 S 4.57x57 Structure Structure
TM4 181 F 4.58x58 Structure Structure
TM4 182 P 4.59x59 Structure Structure
TM4 183 P 4.60x60 Structure Structure
TM4 184 L 4.61x61 Structure Structure
TM4 185 I 4.62x62 AF2 AF2
ECL2 186 S - AF2 AF2
ECL2 187 I - AF2 AF2
ECL2 188 E - AF2 AF2
ECL2 189 K - AF2 AF2
ECL2 190 K - AF2 AF2
ECL2 191 G - AF2 AF2
ECL2 192 G - AF2 AF2
ECL2 193 G - AF2 AF2
ECL2 194 G - AF2 AF2
ECL2 195 G - AF2 AF2
ECL2 196 P - AF2 AF2
ECL2 197 Q - AF2 AF2
ECL2 198 P - AF2 AF2
ECL2 199 A - AF2 AF2
ECL2 200 E - Structure Structure
ECL2 201 P - Structure Structure
ECL2 202 R - Structure Structure
ECL2 203 C 45.50x50 Structure Structure
ECL2 204 E 45.51x51 Structure Structure
ECL2 205 I 45.52x52 Structure Structure
ECL2 206 N - Structure Structure
ECL2 207 D - Structure Structure
TM5 208 Q 5.35x36 Structure Structure
TM5 209 K 5.36x37 Structure Structure
TM5 210 W 5.37x38 Structure Structure
TM5 211 Y 5.38x39 Structure Structure
TM5 212 V 5.39x40 Structure Structure
TM5 213 I 5.40x41 Structure Structure
TM5 214 S 5.41x42 Structure Structure
TM5 215 S 5.42x43 Structure Structure
TM5 216 C 5.43x44 Structure Structure
TM5 217 I 5.44x45 Structure Structure
TM5 218 G 5.45x46 Structure Structure
TM5 219 S 5.46x461 Structure Structure
TM5 220 F 5.47x47 Structure Structure
TM5 221 F 5.48x48 Structure Structure
TM5 222 A 5.49x49 Structure Structure
TM5 223 P 5.50x50 Structure Structure
TM5 224 C 5.51x51 Structure Structure
TM5 225 L 5.52x52 Structure Structure
TM5 226 I 5.53x53 Structure Structure
TM5 227 M 5.54x54 Structure Structure
TM5 228 I 5.55x55 Structure Structure
TM5 229 L 5.56x56 Structure Structure
TM5 230 V 5.57x57 Structure Structure
TM5 231 Y 5.58x58 Structure Structure
TM5 232 V 5.59x59 Structure Structure
TM5 233 R 5.60x60 Structure Structure
TM5 234 I 5.61x61 Structure Structure
TM5 235 Y 5.62x62 Structure Structure
TM5 236 Q 5.63x63 Structure Structure
TM5 237 I 5.64x64 Structure Structure
TM5 238 A 5.65x65 Structure Structure
TM5 239 K 5.66x66 Structure Structure
TM5 240 R 5.67x67 Structure Structure
TM5 241 R 5.68x68 Structure Structure
TM5 242 T 5.69x69 Structure Structure
TM5 243 R 5.70x70 Structure Structure
TM5 244 V 5.71x71 AF2 AF2
TM5 245 P 5.72x72 AF2 AF2
TM5 246 P 5.73x73 AF2 AF2
TM5 247 S 5.74x74 AF2 AF2
TM5 248 R 5.75x75 AF2 AF2
ICL3 249 R - AF2 AF2
ICL3 250 G - AF2 AF2
ICL3 251 P - AF2 AF2
ICL3 252 D - AF2 AF2
ICL3 253 A - AF2 AF2
ICL3 254 V - AF2 AF2
ICL3 255 A - AF2 AF2
ICL3 371 A - AF2 AF2
ICL3 372 A - AF2 AF2
ICL3 373 K - AF2 AF2
ICL3 374 A - AF2 AF2
ICL3 375 S - Structure Structure
ICL3 376 R - Structure Structure
ICL3 377 W - Structure Structure
TM6 378 R 6.24x24 Structure Structure
TM6 379 G 6.25x25 Structure Structure
TM6 380 R 6.26x26 Structure Structure
TM6 381 Q 6.27x27 Structure Structure
TM6 382 N 6.28x28 Structure Structure
TM6 383 R 6.29x29 Structure Structure
TM6 384 E 6.30x30 Structure Structure
TM6 385 K 6.31x31 Structure Structure
TM6 386 R 6.32x32 Structure Structure
TM6 387 F 6.33x33 Structure Structure
TM6 388 T 6.34x34 Structure Structure
TM6 389 F 6.35x35 Structure Structure
TM6 390 V 6.36x36 Structure Structure
TM6 391 L 6.37x37 Structure Structure
TM6 392 A 6.38x38 Structure Structure
TM6 393 V 6.39x39 Structure Structure
TM6 394 V 6.40x40 Structure Structure
TM6 395 I 6.41x41 Structure Structure
TM6 396 G 6.42x42 Structure Structure
TM6 397 V 6.43x43 Structure Structure
TM6 398 F 6.44x44 Structure Structure
TM6 399 V 6.45x45 Structure Structure
TM6 400 V 6.46x46 Structure Structure
TM6 401 C 6.47x47 Structure Structure
TM6 402 W 6.48x48 Structure Structure
TM6 403 F 6.49x49 Structure Structure
TM6 404 P 6.50x50 Structure Structure
TM6 405 F 6.51x51 Structure Structure
TM6 406 F 6.52x52 Structure Structure
TM6 407 F 6.53x53 Structure Structure
TM6 408 T 6.54x54 Structure Structure
TM6 409 Y 6.55x55 Structure Structure
TM6 410 T 6.56x56 Structure Structure
TM6 411 L 6.57x57 Structure Structure
TM6 412 T 6.58x58 Structure Structure
TM6 413 A 6.59x59 Structure Structure
TM6 414 V 6.60x60 Structure Structure
TM6 415 G 6.61x61 Structure Structure
ECL3 416 C - Structure Structure
ECL3 417 S - Structure Structure
ECL3 418 V - Structure Structure
TM7 419 P 7.31x30 Structure Structure
TM7 420 R 7.32x31 Structure Structure
TM7 421 T 7.33x32 Structure Structure
TM7 422 L 7.34x33 Structure Structure
TM7 423 F 7.35x34 Structure Structure
TM7 424 K 7.36x35 Structure Structure
TM7 425 F 7.37x36 Structure Structure
TM7 426 F 7.38x37 Structure Structure
TM7 427 F 7.39x38 Structure Structure
TM7 428 W 7.40x39 Structure Structure
TM7 429 F 7.41x40 Structure Structure
TM7 430 G 7.42x41 Structure Structure
TM7 431 Y 7.43x42 Structure Structure
TM7 432 C 7.44x43 Structure Structure
TM7 433 N 7.45x45 Structure Structure
TM7 434 S 7.46x46 Structure Structure
TM7 435 S 7.47x47 Structure Structure
TM7 436 L 7.48x48 Structure Structure
TM7 437 N 7.49x49 Structure Structure
TM7 438 P 7.50x50 Structure Structure
TM7 439 V 7.51x51 Structure Structure
TM7 440 I 7.52x52 Structure Structure
TM7 441 Y 7.53x53 Structure Structure
TM7 442 T 7.54x54 Structure Structure
TM7 443 I 7.55x55 Structure Structure
TM7 444 F 7.56x56 Structure Structure
H8 445 N 8.47x47 Structure Structure
H8 446 H 8.48x48 Structure Structure
H8 447 D 8.49x49 Structure Structure
H8 448 F 8.50x50 Structure Structure
H8 449 R 8.51x51 Structure Structure
H8 450 R 8.52x52 Structure Structure
H8 451 A 8.53x53 Structure Structure
H8 452 F 8.54x54 Structure Structure
H8 453 K 8.55x55 Structure Structure
H8 454 K 8.56x56 Structure Structure
H8 455 I 8.57x57 Structure Structure
H8 456 L 8.58x58 Structure Structure
H8 457 C 8.59x59 Structure Structure
H8 458 R 8.60x60 AF2 AF2
C-term 459 G - AF2 AF2
C-term 460 D - AF2 AF2
C-term 461 R - AF2 AF2
C-term 462 K - AF2 AF2
C-term 463 R - AF2 AF2
C-term 464 I - AF2 AF2
C-term 465 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Ionic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 241 5x68 G.H5 D 341 G.H5.13
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 351 G.H5.23
Polar TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 154 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 F 387 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 387 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Polar ICL2 L 158 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 158 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 158 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 A 238 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM7 F 444 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 390 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 390 6x36 G.H5 L 353 G.H5.25
Polar TM6 R 383 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 383 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 383 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM5 P 246 5x73 G.S6 Y 320 G.S6.02
Hydrophobic TM5 P 246 5x73 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 P 246 5x73 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 F 387 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 F 387 6x33 G.H5 Y 354 G.H5.26
Polar ICL2 N 157 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 N 157 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 157 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 I 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 391 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 150 3x54 G.H5 L 348 G.H5.20
Polar TM3 I 150 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 150 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 150 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 153 34x50 G.H5 I 344 G.H5.16