Refined structure (7MBX) of Gs - CCK1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 240 from structure (60.9%), 154 from model (39.1%)
Residue sidechains - 223 from structure (56.6%), 171 from model (43.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 Structure AF2
G.HN 9 T G.HN.26 Structure AF2
G.HN 10 E G.HN.27 Structure AF2
G.HN 11 D G.HN.28 Structure AF2
G.HN 12 Q G.HN.29 Structure AF2
G.HN 13 R G.HN.30 Structure AF2
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 Structure Structure
G.H1 63 L G.H1.11 Structure Structure
G.H1 64 H G.H1.12 Structure Structure
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 Structure Structure
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure AF2
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure AF2
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 291 from structure (81.1%), 68 from model (18.9%)
Residue sidechains - 286 from structure (79.7%), 73 from model (20.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 V - AF2 AF2
N-term 4 V - AF2 AF2
N-term 5 D - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 V - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 I - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 C - AF2 AF2
N-term 19 E - AF2 AF2
N-term 20 L - AF2 AF2
N-term 21 G - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 E - AF2 AF2
N-term 24 N - AF2 AF2
N-term 25 E - AF2 AF2
N-term 26 T - AF2 AF2
N-term 27 L - AF2 AF2
N-term 28 F - AF2 AF2
N-term 29 C - AF2 AF2
N-term 30 L - AF2 AF2
N-term 31 D - AF2 AF2
N-term 32 Q - AF2 AF2
N-term 33 P - AF2 AF2
N-term 34 R - AF2 AF2
N-term 35 P - AF2 AF2
N-term 36 S - AF2 AF2
N-term 37 K - AF2 AF2
N-term 38 E - AF2 AF2
TM1 39 W 1.30x30 Structure AF2
TM1 40 Q 1.31x31 Structure Structure
TM1 41 P 1.32x32 Structure Structure
TM1 42 A 1.33x33 Structure Structure
TM1 43 V 1.34x34 Structure Structure
TM1 44 Q 1.35x35 Structure Structure
TM1 45 I 1.36x36 Structure Structure
TM1 46 L 1.37x37 Structure Structure
TM1 47 L 1.38x38 Structure Structure
TM1 48 Y 1.39x39 Structure Structure
TM1 49 S 1.40x40 Structure Structure
TM1 50 L 1.41x41 Structure Structure
TM1 51 I 1.42x42 Structure Structure
TM1 52 F 1.43x43 Structure Structure
TM1 53 L 1.44x44 Structure Structure
TM1 54 L 1.45x45 Structure Structure
TM1 55 S 1.46x46 Structure Structure
TM1 56 V 1.47x47 Structure Structure
TM1 57 L 1.48x48 Structure Structure
TM1 58 G 1.49x49 Structure Structure
TM1 59 N 1.50x50 Structure Structure
TM1 60 T 1.51x51 Structure Structure
TM1 61 L 1.52x52 Structure Structure
TM1 62 V 1.53x53 Structure Structure
TM1 63 I 1.54x54 Structure Structure
TM1 64 T 1.55x55 Structure Structure
TM1 65 V 1.56x56 Structure Structure
TM1 66 L 1.57x57 Structure Structure
TM1 67 I 1.58x58 Structure Structure
TM1 68 R 1.59x59 Structure Structure
TM1 69 N 1.60x60 Structure Structure
ICL1 70 K 12.48x48 Structure Structure
ICL1 71 R 12.49x49 Structure AF2
ICL1 72 M 12.50x50 Structure Structure
ICL1 73 R 12.51x51 Structure Structure
TM2 74 T 2.37x37 Structure Structure
TM2 75 V 2.38x38 Structure Structure
TM2 76 T 2.39x39 Structure Structure
TM2 77 N 2.40x40 Structure Structure
TM2 78 I 2.41x41 Structure Structure
TM2 79 F 2.42x42 Structure Structure
TM2 80 L 2.43x43 Structure Structure
TM2 81 L 2.44x44 Structure Structure
TM2 82 S 2.45x45 Structure Structure
TM2 83 L 2.46x46 Structure Structure
TM2 84 A 2.47x47 Structure Structure
TM2 85 V 2.48x48 Structure Structure
TM2 86 S 2.49x49 Structure Structure
TM2 87 D 2.50x50 Structure Structure
TM2 88 L 2.51x51 Structure Structure
TM2 89 M 2.52x52 Structure Structure
TM2 90 L 2.53x53 Structure Structure
TM2 91 C 2.54x54 Structure Structure
TM2 92 L 2.55x55 Structure Structure
TM2 93 F 2.56x551 Structure Structure
TM2 94 C 2.57x56 Structure Structure
TM2 95 M 2.58x57 Structure Structure
TM2 96 P 2.59x58 Structure Structure
TM2 97 F 2.60x59 Structure Structure
TM2 98 N 2.61x60 Structure Structure
TM2 99 L 2.62x61 Structure Structure
TM2 100 I 2.63x62 Structure Structure
TM2 101 P 2.64x63 Structure Structure
TM2 102 N 2.65x64 Structure Structure
TM2 103 L 2.66x65 Structure Structure
TM2 104 L 2.67x66 Structure Structure
TM2 105 K 2.68x67 Structure Structure
ECL1 106 D 23.49x49 Structure Structure
ECL1 107 F 23.50x50 Structure Structure
ECL1 108 I 23.51x51 Structure Structure
ECL1 109 F 23.52x52 Structure Structure
TM3 110 G 3.21x21 Structure Structure
TM3 111 S 3.22x22 Structure Structure
TM3 112 A 3.23x23 Structure Structure
TM3 113 V 3.24x24 Structure Structure
TM3 114 C 3.25x25 Structure Structure
TM3 115 K 3.26x26 Structure Structure
TM3 116 T 3.27x27 Structure Structure
TM3 117 T 3.28x28 Structure Structure
TM3 118 T 3.29x29 Structure Structure
TM3 119 Y 3.30x30 Structure Structure
TM3 120 F 3.31x31 Structure Structure
TM3 121 M 3.32x32 Structure Structure
TM3 122 G 3.33x33 Structure Structure
TM3 123 T 3.34x34 Structure Structure
TM3 124 S 3.35x35 Structure Structure
TM3 125 V 3.36x36 Structure Structure
TM3 126 S 3.37x37 Structure Structure
TM3 127 V 3.38x38 Structure Structure
TM3 128 S 3.39x39 Structure Structure
TM3 129 T 3.40x40 Structure Structure
TM3 130 F 3.41x41 Structure Structure
TM3 131 N 3.42x42 Structure Structure
TM3 132 L 3.43x43 Structure Structure
TM3 133 V 3.44x44 Structure Structure
TM3 134 A 3.45x45 Structure Structure
TM3 135 I 3.46x46 Structure Structure
TM3 136 S 3.47x47 Structure Structure
TM3 137 L 3.48x48 Structure Structure
TM3 138 E 3.49x49 Structure Structure
TM3 139 R 3.50x50 Structure Structure
TM3 140 Y 3.51x51 Structure Structure
TM3 141 G 3.52x52 Structure Structure
TM3 142 A 3.53x53 Structure Structure
TM3 143 I 3.54x54 Structure Structure
TM3 144 C 3.55x55 Structure Structure
TM3 145 K 3.56x56 Structure Structure
ICL2 146 P 34.50x50 Structure Structure
ICL2 147 L 34.51x51 Structure Structure
ICL2 148 Q 34.52x52 Structure Structure
ICL2 149 S 34.53x53 Structure Structure
ICL2 150 R 34.54x54 Structure Structure
ICL2 151 V 34.55x55 Structure Structure
ICL2 152 W 34.56x56 Structure Structure
ICL2 153 Q 34.57x57 Structure Structure
TM4 154 T 4.38x38 Structure Structure
TM4 155 K 4.39x39 Structure Structure
TM4 156 S 4.40x40 Structure Structure
TM4 157 H 4.41x41 Structure Structure
TM4 158 A 4.42x42 Structure Structure
TM4 159 L 4.43x43 Structure Structure
TM4 160 K 4.44x44 Structure Structure
TM4 161 V 4.45x45 Structure Structure
TM4 162 I 4.46x46 Structure Structure
TM4 163 A 4.47x47 Structure Structure
TM4 164 A 4.48x48 Structure Structure
TM4 165 T 4.49x49 Structure Structure
TM4 166 W 4.50x50 Structure Structure
TM4 167 C 4.51x51 Structure Structure
TM4 168 L 4.52x52 Structure Structure
TM4 169 S 4.53x53 Structure Structure
TM4 170 F 4.54x54 Structure Structure
TM4 171 T 4.55x55 Structure Structure
TM4 172 I 4.56x56 Structure Structure
TM4 173 M 4.57x57 Structure Structure
TM4 174 T 4.58x59 Structure Structure
TM4 175 P 4.59x60 Structure Structure
TM4 176 Y 4.60x61 Structure Structure
TM4 177 P 4.61x62 Structure Structure
TM4 178 I 4.62x63 Structure Structure
TM4 179 Y 4.63x64 Structure Structure
TM4 180 S 4.64x65 Structure Structure
ECL2 181 N - Structure Structure
ECL2 182 L - Structure Structure
ECL2 183 V - Structure Structure
ECL2 184 P - Structure Structure
ECL2 185 F - Structure Structure
ECL2 186 T - Structure Structure
ECL2 187 K - Structure Structure
ECL2 188 N - Structure Structure
ECL2 189 N - Structure Structure
ECL2 190 N - Structure Structure
ECL2 191 Q - Structure Structure
ECL2 192 T - Structure Structure
ECL2 193 A - Structure Structure
ECL2 194 N - Structure Structure
ECL2 195 M - Structure Structure
ECL2 196 C 45.50x50 Structure Structure
ECL2 197 R 45.51x51 Structure Structure
ECL2 198 F 45.52x52 Structure Structure
ECL2 199 L - Structure Structure
ECL2 200 L - Structure Structure
ECL2 201 P - Structure Structure
TM5 202 N 5.31x32 Structure Structure
TM5 203 D 5.32x33 Structure Structure
TM5 204 V 5.33x34 Structure Structure
TM5 205 M 5.34x35 Structure Structure
TM5 206 Q 5.35x36 Structure Structure
TM5 207 Q 5.36x37 Structure Structure
TM5 208 S 5.37x38 Structure Structure
TM5 209 W 5.38x39 Structure Structure
TM5 210 H 5.39x40 Structure Structure
TM5 211 T 5.40x41 Structure Structure
TM5 212 F 5.41x42 Structure Structure
TM5 213 L 5.42x43 Structure Structure
TM5 214 L 5.43x44 Structure Structure
TM5 215 L 5.44x45 Structure Structure
TM5 216 I 5.45x46 Structure Structure
TM5 217 L 5.46x461 Structure Structure
TM5 218 F 5.47x47 Structure Structure
TM5 219 L 5.48x48 Structure Structure
TM5 220 I 5.49x49 Structure Structure
TM5 221 P 5.50x50 Structure Structure
TM5 222 G 5.51x51 Structure Structure
TM5 223 I 5.52x52 Structure Structure
TM5 224 V 5.53x53 Structure Structure
TM5 225 M 5.54x54 Structure Structure
TM5 226 M 5.55x55 Structure Structure
TM5 227 V 5.56x56 Structure Structure
TM5 228 A 5.57x57 Structure Structure
TM5 229 Y 5.58x58 Structure Structure
TM5 230 G 5.59x59 Structure Structure
TM5 231 L 5.60x60 Structure Structure
TM5 232 I 5.61x61 Structure Structure
TM5 233 S 5.62x62 Structure Structure
TM5 234 L 5.63x63 Structure Structure
TM5 235 E 5.64x64 Structure Structure
TM5 236 L 5.65x65 Structure Structure
TM5 237 Y 5.66x66 Structure Structure
TM5 238 Q 5.67x67 Structure Structure
TM5 239 G 5.68x68 Structure Structure
TM5 240 I 5.69x69 Structure Structure
TM5 241 K 5.70x70 Structure AF2
TM5 242 F 5.71x71 Structure Structure
TM5 243 E 5.72x72 Structure AF2
TM5 244 A 5.73x73 AF2 AF2
TM5 245 S 5.74x74 AF2 AF2
ICL3 246 Q - AF2 AF2
ICL3 247 K - AF2 AF2
ICL3 248 K - AF2 AF2
ICL3 249 S - AF2 AF2
ICL3 250 A - AF2 AF2
ICL3 251 K - AF2 AF2
ICL3 252 E - AF2 AF2
ICL3 294 N - AF2 AF2
ICL3 295 R - AF2 AF2
ICL3 296 I - AF2 AF2
ICL3 297 R - AF2 AF2
ICL3 298 S - AF2 AF2
ICL3 299 N - AF2 AF2
ICL3 300 S - AF2 AF2
TM6 301 S 6.23x23 Structure Structure
TM6 302 A 6.24x24 Structure Structure
TM6 303 A 6.25x25 Structure Structure
TM6 304 N 6.26x26 Structure AF2
TM6 305 L 6.27x27 Structure Structure
TM6 306 M 6.28x28 Structure Structure
TM6 307 A 6.29x29 Structure Structure
TM6 308 K 6.30x30 Structure Structure
TM6 309 K 6.31x31 Structure Structure
TM6 310 R 6.32x32 Structure Structure
TM6 311 V 6.33x33 Structure Structure
TM6 312 I 6.34x34 Structure Structure
TM6 313 R 6.35x35 Structure Structure
TM6 314 M 6.36x36 Structure Structure
TM6 315 L 6.37x37 Structure Structure
TM6 316 I 6.38x38 Structure Structure
TM6 317 V 6.39x39 Structure Structure
TM6 318 I 6.40x40 Structure Structure
TM6 319 V 6.41x41 Structure Structure
TM6 320 V 6.42x42 Structure Structure
TM6 321 L 6.43x43 Structure Structure
TM6 322 F 6.44x44 Structure Structure
TM6 323 F 6.45x45 Structure Structure
TM6 324 L 6.46x46 Structure Structure
TM6 325 C 6.47x47 Structure Structure
TM6 326 W 6.48x48 Structure Structure
TM6 327 M 6.49x49 Structure Structure
TM6 328 P 6.50x50 Structure Structure
TM6 329 I 6.51x51 Structure Structure
TM6 330 F 6.52x52 Structure Structure
TM6 331 S 6.53x53 Structure Structure
TM6 332 A 6.54x54 Structure Structure
TM6 333 N 6.55x55 Structure Structure
TM6 334 A 6.56x56 Structure Structure
TM6 335 W 6.57x57 Structure Structure
TM6 336 R 6.58x58 Structure Structure
TM6 337 A 6.59x59 Structure Structure
TM6 338 Y 6.60x60 Structure Structure
TM6 339 D 6.61x61 Structure Structure
ECL3 340 T - Structure Structure
ECL3 341 A - Structure Structure
ECL3 342 S - Structure Structure
ECL3 343 A - Structure Structure
ECL3 344 E - Structure Structure
ECL3 345 R - Structure Structure
ECL3 346 R - Structure Structure
ECL3 347 L - Structure Structure
ECL3 348 S - Structure Structure
TM7 349 G 7.32x31 Structure Structure
TM7 350 T 7.33x32 Structure Structure
TM7 351 P 7.34x33 Structure Structure
TM7 352 I 7.35x34 Structure Structure
TM7 353 S 7.36x35 Structure Structure
TM7 354 F 7.37x36 Structure Structure
TM7 355 I 7.38x37 Structure Structure
TM7 356 L 7.39x38 Structure Structure
TM7 357 L 7.40x39 Structure Structure
TM7 358 L 7.41x40 Structure Structure
TM7 359 S 7.42x41 Structure Structure
TM7 360 Y 7.43x42 Structure Structure
TM7 361 T 7.44x43 Structure Structure
TM7 362 S 7.45x45 Structure Structure
TM7 363 S 7.46x46 Structure Structure
TM7 364 C 7.47x47 Structure Structure
TM7 365 V 7.48x48 Structure Structure
TM7 366 N 7.49x49 Structure Structure
TM7 367 P 7.50x50 Structure Structure
TM7 368 I 7.51x51 Structure Structure
TM7 369 I 7.52x52 Structure Structure
TM7 370 Y 7.53x53 Structure Structure
TM7 371 C 7.54x54 Structure Structure
TM7 372 F 7.55x55 Structure Structure
TM7 373 M 7.56x56 Structure Structure
H8 374 N 8.47x47 Structure Structure
H8 375 K 8.48x48 Structure Structure
H8 376 R 8.49x49 Structure Structure
H8 377 F 8.50x50 Structure Structure
H8 378 R 8.51x51 Structure Structure
H8 379 L 8.52x52 Structure Structure
H8 380 G 8.53x53 Structure Structure
H8 381 F 8.54x54 Structure Structure
H8 382 M 8.55x55 Structure Structure
H8 383 A 8.56x56 Structure Structure
H8 384 T 8.57x57 Structure Structure
H8 385 F 8.58x58 Structure Structure
H8 386 P 8.59x59 Structure Structure
H8 387 C 8.60x60 AF2 AF2
H8 388 C 8.61x61 AF2 AF2
H8 389 P 8.62x62 AF2 AF2
H8 390 N 8.63x63 AF2 AF2
C-term 391 P - AF2 AF2
C-term 392 G - AF2 AF2
C-term 393 P - AF2 AF2
C-term 394 P - AF2 AF2
C-term 395 G - AF2 AF2
C-term 396 A - AF2 AF2
C-term 397 R - AF2 AF2
C-term 398 G - AF2 AF2
C-term 399 E - AF2 AF2
C-term 400 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Ionic TM5 E 235 5x64 G.H5 R 380 G.H5.12
Polar TM5 E 235 5x64 G.H5 R 380 G.H5.12
Polar TM6 N 304 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 N 304 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 L 147 34x51 G.S3 F 219 G.S3.03
Polar TM3 C 144 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 C 144 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 Q 384 G.H5.16
Polar ICL2 R 150 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 150 34x54 G.H5 H 387 G.H5.19
Polar H8 R 378 8x51 G.H5 L 393 G.H5.25
Van-der-waals H8 R 378 8x51 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM7 M 373 7x56 G.H5 L 393 G.H5.25
Van-der-waals TM7 M 373 7x56 G.H5 L 393 G.H5.25
Hydrophobic H8 R 376 8x49 G.H5 R 389 G.H5.21
Polar ICL3 I 296 - G.h4s6 A 351 G.h4s6.04
Hydrophobic ICL3 I 296 - G.h4s6 A 351 G.h4s6.04
Van-der-waals ICL3 I 296 - G.h4s6 A 351 G.h4s6.04
Hydrophobic TM3 I 143 3x54 G.H5 L 388 G.H5.20
Polar ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 150 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 147 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 147 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 146 34x50 G.H5 I 383 G.H5.15
Van-der-waals TM6 K 308 6x30 G.H5 L 388 G.H5.20
Hydrophobic ICL3 I 296 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 I 296 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 147 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM6 N 304 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 N 304 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 V 311 6x33 G.H5 L 388 G.H5.20
Hydrophobic ICL2 R 150 34x54 G.H5 I 383 G.H5.15
Polar ICL3 R 297 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 R 297 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 R 297 - G.h4s6 T 350 G.h4s6.03
Polar ICL3 S 249 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 S 249 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 S 249 - G.hgh4 D 323 G.hgh4.13
Van-der-waals TM3 I 143 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 M 314 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 R 380 G.H5.12
Polar H8 K 375 8x48 G.H5 L 393 G.H5.25
Hydrophobic H8 K 375 8x48 G.H5 L 393 G.H5.25
Van-der-waals H8 K 375 8x48 G.H5 L 393 G.H5.25
Hydrophobic H8 K 375 8x48 G.H5 L 394 G.H5.26
Hydrophobic ICL3 R 297 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 R 297 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 P 146 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 147 34x51 G.H5 C 379 G.H5.11
Polar ICL2 Q 148 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 Q 148 34x52 G.s2s3 D 215 G.s2s3.01
Polar H8 K 375 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 375 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 375 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 376 8x49 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 Q 148 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 Q 148 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 L 236 5x65 G.H5 L 388 G.H5.20
Polar TM3 A 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 H 387 G.H5.19
Ionic TM5 E 243 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL3 I 296 - G.H4 R 347 G.H4.17
Polar ICL3 A 250 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 A 250 - G.hgh4 D 323 G.hgh4.13
Van-der-waals H8 N 374 8x47 G.H5 E 392 G.H5.24
Polar H8 N 374 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 N 374 8x47 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 L 147 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 147 34x51 G.S1 H 41 G.S1.02
Polar ICL2 R 150 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 150 34x54 G.S1 H 41 G.S1.02
Hydrophobic C-term E 399 - G.H3 W 281 G.H3.17
Van-der-waals C-term E 399 - G.H3 W 281 G.H3.17