Refined structure (7QVM) of Go - OT receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 210 from structure (59.3%), 144 from model (40.7%)
Residue sidechains - 190 from structure (53.7%), 164 from model (46.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 E G.HN.33 Structure AF2
G.HN 10 R G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure AF2
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 A G.HN.42 Structure AF2
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure AF2
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 AF2 AF2
G.H1 53 M G.H1.08 AF2 AF2
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 Structure Structure
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 N G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure AF2
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 D G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure AF2
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 G G.s4h3.03 Structure AF2
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 AF2 AF2
G.s4h3 233 Q G.s4h3.06 AF2 AF2
G.s4h3 234 V G.s4h3.07 AF2 AF2
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 H G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 T G.s4h3.13 AF2 AF2
G.s4h3 241 T G.s4h3.14 AF2 AF2
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure Structure
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure Structure
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure Structure
G.HG 281 K G.HG.12 Structure Structure
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure AF2
G.hgh4 291 Y G.hgh4.05 Structure AF2
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 T G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure Structure
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure Structure
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure AF2
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure AF2
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure AF2
G.H5 345 A G.H5.17 Structure AF2
G.H5 346 N G.H5.18 Structure AF2
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure Structure
G.H5 350 G G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure AF2
G.H5 352 G G.H5.24 Structure AF2
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 250 from structure (71.8%), 98 from model (28.2%)
Residue sidechains - 244 from structure (70.1%), 104 from model (29.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 N - AF2 AF2
N-term 9 W - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 N - AF2 AF2
N-term 16 A - AF2 AF2
N-term 17 S - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 G - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 E - AF2 AF2
N-term 25 G - AF2 AF2
N-term 26 N - AF2 AF2
N-term 27 R - AF2 AF2
N-term 28 T - AF2 AF2
N-term 29 A - AF2 AF2
N-term 30 G - AF2 AF2
N-term 31 P - AF2 AF2
N-term 32 P - AF2 AF2
N-term 33 R - AF2 AF2
N-term 34 R - AF2 AF2
TM1 35 N 1.28x28 Structure Structure
TM1 36 E 1.29x29 Structure Structure
TM1 37 A 1.30x30 Structure Structure
TM1 38 L 1.31x31 Structure Structure
TM1 39 A 1.32x32 Structure Structure
TM1 40 R 1.33x33 Structure Structure
TM1 41 V 1.34x34 Structure Structure
TM1 42 E 1.35x35 Structure Structure
TM1 43 V 1.36x36 Structure Structure
TM1 44 A 1.37x37 Structure Structure
TM1 45 V 1.38x38 Structure Structure
TM1 46 L 1.39x39 Structure Structure
TM1 47 C 1.40x40 Structure Structure
TM1 48 L 1.41x41 Structure Structure
TM1 49 I 1.42x42 Structure Structure
TM1 50 L 1.43x43 Structure Structure
TM1 51 L 1.44x44 Structure Structure
TM1 52 L 1.45x45 Structure Structure
TM1 53 A 1.46x46 Structure Structure
TM1 54 L 1.47x47 Structure Structure
TM1 55 S 1.48x48 Structure Structure
TM1 56 G 1.49x49 Structure Structure
TM1 57 N 1.50x50 Structure Structure
TM1 58 A 1.51x51 Structure Structure
TM1 59 C 1.52x52 Structure Structure
TM1 60 V 1.53x53 Structure Structure
TM1 61 L 1.54x54 Structure Structure
TM1 62 L 1.55x55 Structure Structure
TM1 63 A 1.56x56 Structure Structure
TM1 64 L 1.57x57 Structure Structure
TM1 65 R 1.58x58 Structure Structure
TM1 66 T 1.59x59 AF2 AF2
TM1 67 T 1.60x60 AF2 AF2
ICL1 68 R 12.48x48 AF2 AF2
ICL1 69 Q 12.49x49 AF2 AF2
ICL1 70 K 12.50x50 AF2 AF2
ICL1 71 H 12.51x51 AF2 AF2
TM2 72 S 2.37x37 Structure Structure
TM2 73 R 2.38x38 Structure Structure
TM2 74 L 2.39x39 Structure Structure
TM2 75 F 2.40x40 Structure Structure
TM2 76 F 2.41x41 Structure Structure
TM2 77 F 2.42x42 Structure Structure
TM2 78 M 2.43x43 Structure Structure
TM2 79 K 2.44x44 Structure Structure
TM2 80 H 2.45x45 Structure Structure
TM2 81 L 2.46x46 Structure Structure
TM2 82 S 2.47x47 Structure Structure
TM2 83 I 2.48x48 Structure Structure
TM2 84 A 2.49x49 Structure Structure
TM2 85 D 2.50x50 Structure Structure
TM2 86 L 2.51x51 Structure Structure
TM2 87 V 2.52x52 Structure Structure
TM2 88 V 2.53x53 Structure Structure
TM2 89 A 2.54x54 Structure Structure
TM2 90 V 2.55x55 Structure Structure
TM2 91 F 2.56x551 Structure Structure
TM2 92 Q 2.57x56 Structure Structure
TM2 93 V 2.58x57 Structure Structure
TM2 94 L 2.59x58 Structure Structure
TM2 95 P 2.60x59 Structure Structure
TM2 96 Q 2.61x60 Structure Structure
TM2 97 L 2.62x61 Structure Structure
TM2 98 L 2.63x62 Structure Structure
TM2 99 W 2.64x63 Structure Structure
TM2 100 D 2.65x64 Structure Structure
TM2 101 I 2.66x65 Structure Structure
TM2 102 T 2.67x66 Structure Structure
TM2 103 F 2.68x67 Structure Structure
ECL1 104 R 23.49x49 Structure Structure
ECL1 105 F 23.50x50 Structure Structure
ECL1 106 Y 23.51x51 Structure Structure
ECL1 107 G 23.52x52 Structure Structure
TM3 108 P 3.21x21 Structure Structure
TM3 109 D 3.22x22 Structure Structure
TM3 110 L 3.23x23 Structure Structure
TM3 111 L 3.24x24 Structure Structure
TM3 112 C 3.25x25 Structure Structure
TM3 113 R 3.26x26 Structure Structure
TM3 114 L 3.27x27 Structure Structure
TM3 115 V 3.28x28 Structure Structure
TM3 116 K 3.29x29 Structure Structure
TM3 117 Y 3.30x30 Structure Structure
TM3 118 L 3.31x31 Structure Structure
TM3 119 Q 3.32x32 Structure Structure
TM3 120 V 3.33x33 Structure Structure
TM3 121 V 3.34x34 Structure Structure
TM3 122 G 3.35x35 Structure Structure
TM3 123 M 3.36x36 Structure Structure
TM3 124 F 3.37x37 Structure Structure
TM3 125 A 3.38x38 Structure Structure
TM3 126 S 3.39x39 Structure Structure
TM3 127 T 3.40x40 Structure Structure
TM3 128 Y 3.41x41 Structure Structure
TM3 129 L 3.42x42 Structure Structure
TM3 130 L 3.43x43 Structure Structure
TM3 131 L 3.44x44 Structure Structure
TM3 132 L 3.45x45 Structure Structure
TM3 133 M 3.46x46 Structure Structure
TM3 134 S 3.47x47 Structure Structure
TM3 135 L 3.48x48 Structure Structure
TM3 136 D 3.49x49 Structure Structure
TM3 137 R 3.50x50 Structure Structure
TM3 138 C 3.51x51 Structure Structure
TM3 139 L 3.52x52 Structure Structure
TM3 140 A 3.53x53 Structure Structure
TM3 141 I 3.54x54 Structure Structure
TM3 142 C 3.55x55 Structure Structure
TM3 143 Q 3.56x56 Structure Structure
ICL2 144 P - Structure Structure
ICL2 145 L - AF2 AF2
ICL2 146 R - AF2 AF2
ICL2 147 S - AF2 AF2
ICL2 148 L - AF2 AF2
TM4 149 R 4.38x38 AF2 AF2
TM4 150 R 4.39x39 Structure Structure
TM4 151 R 4.40x40 Structure AF2
TM4 152 T 4.41x41 Structure Structure
TM4 153 D 4.42x42 Structure AF2
TM4 154 R 4.43x43 Structure AF2
TM4 155 L 4.44x44 Structure Structure
TM4 156 A 4.45x45 Structure Structure
TM4 157 V 4.46x46 Structure Structure
TM4 158 L 4.47x47 Structure Structure
TM4 159 A 4.48x48 Structure Structure
TM4 160 T 4.49x49 Structure Structure
TM4 161 W 4.50x50 Structure Structure
TM4 162 L 4.51x51 Structure Structure
TM4 163 G 4.52x52 Structure Structure
TM4 164 C 4.53x53 Structure Structure
TM4 165 L 4.54x54 Structure Structure
TM4 166 V 4.55x55 Structure Structure
TM4 167 A 4.56x56 Structure Structure
TM4 168 S 4.57x57 Structure Structure
TM4 169 A 4.58x59 Structure Structure
TM4 170 P 4.59x60 Structure Structure
TM4 171 Q 4.60x61 Structure Structure
TM4 172 V 4.61x62 Structure Structure
TM4 173 H 4.62x63 Structure Structure
TM4 174 I 4.63x64 Structure Structure
TM4 175 F 4.64x65 Structure Structure
ECL2 176 S - Structure Structure
ECL2 177 L - Structure Structure
ECL2 178 R - Structure AF2
ECL2 179 E - Structure Structure
ECL2 180 V - AF2 AF2
ECL2 181 A - AF2 AF2
ECL2 182 D - AF2 AF2
ECL2 183 G - AF2 AF2
ECL2 184 V - Structure Structure
ECL2 185 F - Structure Structure
ECL2 186 D - Structure Structure
ECL2 187 C 45.50x50 Structure Structure
ECL2 188 W 45.51x51 Structure Structure
ECL2 189 A 45.52x52 Structure Structure
ECL2 190 V - Structure Structure
ECL2 191 F - Structure Structure
ECL2 192 I - Structure Structure
ECL2 193 Q - Structure Structure
ECL2 194 P - Structure Structure
TM5 195 W 5.33x34 Structure Structure
TM5 196 G 5.34x35 Structure Structure
TM5 197 P 5.35x36 Structure Structure
TM5 198 K 5.36x37 Structure Structure
TM5 199 A 5.37x38 Structure Structure
TM5 200 Y 5.38x39 Structure Structure
TM5 201 I 5.39x40 Structure Structure
TM5 202 T 5.40x41 Structure Structure
TM5 203 W 5.41x42 Structure Structure
TM5 204 I 5.42x43 Structure Structure
TM5 205 T 5.43x44 Structure Structure
TM5 206 L 5.44x45 Structure Structure
TM5 207 A 5.45x46 Structure Structure
TM5 208 V 5.46x461 Structure Structure
TM5 209 Y 5.47x47 Structure Structure
TM5 210 I 5.48x48 Structure Structure
TM5 211 V 5.49x49 Structure Structure
TM5 212 P 5.50x50 Structure Structure
TM5 213 V 5.51x51 Structure Structure
TM5 214 I 5.52x52 Structure Structure
TM5 215 V 5.53x53 Structure Structure
TM5 216 L 5.54x54 Structure Structure
TM5 217 A 5.55x55 Structure Structure
TM5 218 A 5.56x56 Structure AF2
TM5 219 C 5.57x57 Structure Structure
TM5 220 Y 5.58x58 Structure Structure
TM5 221 G 5.59x59 Structure Structure
TM5 222 L 5.60x60 Structure Structure
TM5 223 I 5.61x61 Structure Structure
TM5 224 S 5.62x62 Structure Structure
TM5 225 F 5.63x63 Structure Structure
TM5 226 K 5.64x64 Structure Structure
TM5 227 I 5.65x65 Structure Structure
TM5 228 W 5.66x66 Structure Structure
TM5 229 Q 5.67x67 Structure Structure
TM5 230 N 5.68x68 Structure Structure
TM5 231 L 5.69x69 AF2 AF2
TM5 232 R 5.70x70 AF2 AF2
TM5 233 L 5.71x71 AF2 AF2
TM5 234 K 5.72x72 AF2 AF2
TM5 235 T 5.73x73 AF2 AF2
TM5 236 A 5.74x74 AF2 AF2
TM5 237 A 5.75x75 AF2 AF2
TM5 238 A 5.76x76 AF2 AF2
ICL3 239 A - AF2 AF2
ICL3 240 A - AF2 AF2
ICL3 241 A - AF2 AF2
ICL3 242 E - AF2 AF2
ICL3 243 A - AF2 AF2
ICL3 244 P - AF2 AF2
ICL3 245 E - AF2 AF2
ICL3 257 L - AF2 AF2
ICL3 258 A - AF2 AF2
ICL3 259 R - AF2 AF2
ICL3 260 V - AF2 AF2
ICL3 261 S - AF2 AF2
ICL3 262 S - AF2 AF2
ICL3 263 V - AF2 AF2
TM6 264 K 6.24x24 AF2 AF2
TM6 265 L 6.25x25 AF2 AF2
TM6 266 I 6.26x26 AF2 AF2
TM6 267 S 6.27x27 AF2 AF2
TM6 268 K 6.28x28 AF2 AF2
TM6 269 A 6.29x29 AF2 AF2
TM6 270 K 6.30x30 Structure AF2
TM6 271 I 6.31x31 Structure Structure
TM6 272 R 6.32x32 Structure Structure
TM6 273 T 6.33x33 Structure Structure
TM6 274 V 6.34x34 Structure Structure
TM6 275 K 6.35x35 Structure Structure
TM6 276 M 6.36x36 Structure Structure
TM6 277 T 6.37x37 Structure Structure
TM6 278 F 6.38x38 Structure Structure
TM6 279 I 6.39x39 Structure Structure
TM6 280 I 6.40x40 Structure Structure
TM6 281 V 6.41x41 Structure Structure
TM6 282 L 6.42x42 Structure Structure
TM6 283 A 6.43x43 Structure Structure
TM6 284 F 6.44x44 Structure Structure
TM6 285 I 6.45x45 Structure Structure
TM6 286 V 6.46x46 Structure Structure
TM6 287 C 6.47x47 Structure Structure
TM6 288 W 6.48x48 Structure Structure
TM6 289 T 6.49x49 Structure Structure
TM6 290 P 6.50x50 Structure Structure
TM6 291 F 6.51x51 Structure Structure
TM6 292 F 6.52x52 Structure Structure
TM6 293 F 6.53x53 Structure Structure
TM6 294 V 6.54x54 Structure Structure
TM6 295 Q 6.55x55 Structure Structure
TM6 296 M 6.56x56 Structure Structure
TM6 297 W 6.57x57 Structure Structure
TM6 298 S 6.58x58 Structure Structure
TM6 299 V 6.59x59 Structure Structure
TM6 300 W 6.60x60 Structure Structure
ECL3 301 D - Structure Structure
ECL3 302 A - Structure Structure
ECL3 303 N - Structure Structure
ECL3 304 A - Structure Structure
ECL3 305 P - Structure Structure
TM7 306 K 7.30x29 Structure Structure
TM7 307 E 7.31x30 Structure Structure
TM7 308 A 7.32x31 Structure Structure
TM7 309 S 7.33x32 Structure Structure
TM7 310 A 7.34x33 Structure Structure
TM7 311 F 7.35x34 Structure Structure
TM7 312 I 7.36x35 Structure Structure
TM7 313 I 7.37x36 Structure Structure
TM7 314 V 7.38x37 Structure Structure
TM7 315 M 7.39x38 Structure Structure
TM7 316 L 7.40x39 Structure Structure
TM7 317 L 7.41x40 Structure Structure
TM7 318 A 7.42x41 Structure Structure
TM7 319 S 7.43x42 Structure Structure
TM7 320 L 7.44x43 Structure Structure
TM7 321 N 7.45x45 Structure Structure
TM7 322 S 7.46x46 Structure Structure
TM7 323 C 7.47x47 Structure Structure
TM7 324 C 7.48x48 Structure Structure
TM7 325 N 7.49x49 Structure Structure
TM7 326 P 7.50x50 Structure Structure
TM7 327 W 7.51x51 Structure Structure
TM7 328 I 7.52x52 Structure Structure
TM7 329 Y 7.53x53 Structure Structure
TM7 330 M 7.54x54 Structure Structure
TM7 331 L 7.55x55 Structure Structure
TM7 332 F 7.56x56 Structure Structure
H8 333 T 8.47x47 Structure Structure
H8 334 G 8.48x48 Structure Structure
H8 335 H 8.49x49 Structure Structure
H8 336 L 8.50x50 Structure Structure
H8 337 F 8.51x51 Structure Structure
H8 338 H 8.52x52 Structure Structure
H8 339 E 8.53x53 AF2 AF2
H8 340 L 8.54x54 AF2 AF2
H8 341 V 8.55x55 AF2 AF2
H8 342 Q 8.56x56 AF2 AF2
H8 343 R 8.57x57 AF2 AF2
H8 344 F 8.58x58 AF2 AF2
H8 345 L 8.59x59 AF2 AF2
H8 346 C 8.60x60 AF2 AF2
H8 347 C 8.61x61 AF2 AF2
H8 348 S 8.62x62 AF2 AF2
H8 349 A 8.63x63 AF2 AF2
C-term 350 S - AF2 AF2
C-term 351 Y - AF2 AF2
C-term 352 L - AF2 AF2
C-term 353 K - AF2 AF2
C-term 354 G - AF2 AF2
C-term 355 R - AF2 AF2
C-term 356 R - AF2 AF2
C-term 357 L - AF2 AF2
C-term 358 G - AF2 AF2
C-term 359 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 227 5x65 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 227 5x65 G.H5 L 353 G.H5.25
Polar TM6 R 272 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 272 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 272 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 L 145 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 145 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 144 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 144 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 257 - G.S6 C 321 G.S6.03
Van-der-waals ICL3 L 257 - G.S6 C 321 G.S6.03
Hydrophobic TM5 I 223 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 227 5x65 G.H5 L 348 G.H5.20
Polar ICL2 P 144 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 144 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 144 - G.H5 N 347 G.H5.19
Polar ICL3 S 261 - G.h4s6 P 315 G.h4s6.09
Hydrophobic ICL3 V 260 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 V 260 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 272 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 141 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM4 R 149 4x38 G.HN I 28 G.HN.52
Van-der-waals TM4 R 149 4x38 G.HN I 28 G.HN.52
Hydrophobic TM3 I 141 3x54 G.H5 N 347 G.H5.19
Polar ICL3 E 245 - G.H4 Y 303 G.H4.10
Hydrophobic ICL3 E 245 - G.H4 Y 303 G.H4.10
Hydrophobic ICL3 E 245 - G.H4 A 306 G.H4.13
Van-der-waals ICL3 E 245 - G.H4 A 306 G.H4.13
Ionic ICL1 K 70 12x50 G.h2s4 D 218 G.h2s4.03
Hydrophobic ICL3 L 257 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 L 257 - G.H4 E 309 G.H4.16
Hydrophobic TM6 A 269 6x29 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 144 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 144 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 257 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 L 257 - G.H4 Q 305 G.H4.12
Hydrophobic ICL3 A 243 - G.H4 A 302 G.H4.08
Hydrophobic ICL2 L 145 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 145 - G.H5 T 340 G.H5.12
Hydrophobic TM3 I 141 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL3 E 245 - G.H4 A 302 G.H4.08
Van-der-waals ICL3 E 245 - G.H4 A 302 G.H4.08