Refined structure (7SQO) of Gi1 - OX2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 194 from structure (54.8%), 160 from model (45.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure AF2
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure AF2
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure AF2
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure AF2
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure AF2
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (71.5%), 107 from model (28.5%)
Residue sidechains - 259 from structure (68.9%), 117 from model (31.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 K - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 E - AF2 AF2
N-term 8 D - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 C - AF2 AF2
N-term 13 R - AF2 AF2
N-term 14 N - AF2 AF2
N-term 15 W - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 S - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 E - AF2 AF2
N-term 21 L - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 E - AF2 AF2
N-term 24 T - AF2 AF2
N-term 25 Q - AF2 AF2
N-term 26 E - AF2 AF2
N-term 27 P - AF2 AF2
N-term 28 F - AF2 AF2
N-term 29 L - AF2 AF2
N-term 30 N - AF2 AF2
N-term 31 P - AF2 AF2
N-term 32 T - AF2 AF2
N-term 33 D - AF2 AF2
N-term 34 Y - AF2 AF2
N-term 35 D - AF2 AF2
N-term 36 D - AF2 AF2
N-term 37 E - AF2 AF2
N-term 38 E - AF2 AF2
N-term 39 F - AF2 AF2
N-term 40 L - AF2 AF2
N-term 41 R - AF2 AF2
N-term 42 Y - AF2 AF2
N-term 43 L - AF2 AF2
N-term 44 W - AF2 AF2
N-term 45 R - AF2 AF2
N-term 46 E - AF2 AF2
N-term 47 Y - AF2 AF2
N-term 48 L - AF2 AF2
N-term 49 H - AF2 AF2
N-term 50 P - AF2 AF2
N-term 51 K - AF2 AF2
N-term 52 E - AF2 AF2
TM1 53 Y 1.31x31 AF2 AF2
TM1 54 E 1.32x32 AF2 AF2
TM1 55 W 1.33x33 AF2 AF2
TM1 56 V 1.34x34 Structure Structure
TM1 57 L 1.35x35 Structure Structure
TM1 58 I 1.36x36 Structure Structure
TM1 59 A 1.37x37 Structure Structure
TM1 60 G 1.38x38 Structure Structure
TM1 61 Y 1.39x39 Structure Structure
TM1 62 I 1.40x40 Structure Structure
TM1 63 I 1.41x41 Structure Structure
TM1 64 V 1.42x42 Structure Structure
TM1 65 F 1.43x43 Structure Structure
TM1 66 V 1.44x44 Structure Structure
TM1 67 V 1.45x45 Structure Structure
TM1 68 A 1.46x46 Structure Structure
TM1 69 L 1.47x47 Structure Structure
TM1 70 I 1.48x48 Structure Structure
TM1 71 G 1.49x49 Structure Structure
TM1 72 N 1.50x50 Structure Structure
TM1 73 V 1.51x51 Structure Structure
TM1 74 L 1.52x52 Structure Structure
TM1 75 V 1.53x53 Structure Structure
TM1 76 C 1.54x54 Structure Structure
TM1 77 V 1.55x55 Structure Structure
TM1 78 A 1.56x56 Structure Structure
TM1 79 V 1.57x57 Structure Structure
TM1 80 W 1.58x58 Structure Structure
TM1 81 K 1.59x59 Structure Structure
TM1 82 N 1.60x60 Structure Structure
ICL1 83 H 12.48x48 Structure Structure
ICL1 84 H 12.49x49 Structure Structure
ICL1 85 M 12.50x50 Structure Structure
ICL1 86 R 12.51x51 Structure Structure
TM2 87 T 2.37x37 Structure Structure
TM2 88 V 2.38x38 Structure Structure
TM2 89 T 2.39x39 Structure Structure
TM2 90 N 2.40x40 Structure Structure
TM2 91 Y 2.41x41 Structure Structure
TM2 92 F 2.42x42 Structure Structure
TM2 93 I 2.43x43 Structure Structure
TM2 94 V 2.44x44 Structure Structure
TM2 95 N 2.45x45 Structure Structure
TM2 96 L 2.46x46 Structure Structure
TM2 97 S 2.47x47 Structure Structure
TM2 98 L 2.48x48 Structure Structure
TM2 99 A 2.49x49 Structure Structure
TM2 100 D 2.50x50 Structure Structure
TM2 101 V 2.51x51 Structure Structure
TM2 102 L 2.52x52 Structure Structure
TM2 103 V 2.53x53 Structure Structure
TM2 104 T 2.54x54 Structure Structure
TM2 105 I 2.55x55 Structure Structure
TM2 106 T 2.56x551 Structure Structure
TM2 107 C 2.57x56 Structure Structure
TM2 108 L 2.58x57 Structure Structure
TM2 109 P 2.59x58 Structure Structure
TM2 110 A 2.60x59 Structure Structure
TM2 111 T 2.61x60 Structure Structure
TM2 112 L 2.62x61 Structure Structure
TM2 113 V 2.63x62 Structure Structure
TM2 114 V 2.64x63 Structure Structure
TM2 115 D 2.65x64 Structure Structure
TM2 116 I 2.66x65 Structure Structure
TM2 117 T 2.67x66 Structure Structure
TM2 118 E 2.68x67 Structure Structure
ECL1 119 T 23.49x49 Structure Structure
ECL1 120 W 23.50x50 Structure Structure
ECL1 121 F 23.51x51 Structure Structure
ECL1 122 F 23.52x52 Structure Structure
TM3 123 G 3.21x21 Structure Structure
TM3 124 Q 3.22x22 Structure Structure
TM3 125 S 3.23x23 Structure Structure
TM3 126 L 3.24x24 Structure Structure
TM3 127 C 3.25x25 Structure Structure
TM3 128 K 3.26x26 Structure Structure
TM3 129 V 3.27x27 Structure Structure
TM3 130 I 3.28x28 Structure Structure
TM3 131 P 3.29x29 Structure Structure
TM3 132 Y 3.30x30 Structure Structure
TM3 133 L 3.31x31 Structure Structure
TM3 134 Q 3.32x32 Structure Structure
TM3 135 T 3.33x33 Structure Structure
TM3 136 V 3.34x34 Structure Structure
TM3 137 S 3.35x35 Structure Structure
TM3 138 V 3.36x36 Structure Structure
TM3 139 S 3.37x37 Structure Structure
TM3 140 V 3.38x38 Structure Structure
TM3 141 S 3.39x39 Structure Structure
TM3 142 V 3.40x40 Structure Structure
TM3 143 L 3.41x41 Structure Structure
TM3 144 T 3.42x42 Structure Structure
TM3 145 L 3.43x43 Structure Structure
TM3 146 S 3.44x44 Structure Structure
TM3 147 C 3.45x45 Structure Structure
TM3 148 I 3.46x46 Structure Structure
TM3 149 A 3.47x47 Structure Structure
TM3 150 L 3.48x48 Structure Structure
TM3 151 D 3.49x49 Structure Structure
TM3 152 R 3.50x50 Structure Structure
TM3 153 W 3.51x51 Structure Structure
TM3 154 Y 3.52x52 Structure Structure
TM3 155 A 3.53x53 Structure Structure
TM3 156 I 3.54x54 Structure Structure
TM3 157 C 3.55x55 Structure Structure
TM3 158 H 3.56x56 Structure Structure
ICL2 159 P 34.50x50 Structure Structure
ICL2 160 L 34.51x51 Structure Structure
ICL2 161 M 34.52x52 Structure Structure
ICL2 162 F 34.53x53 Structure Structure
ICL2 163 K - Structure Structure
ICL2 164 S - Structure Structure
TM4 165 T 4.38x38 Structure Structure
TM4 166 A 4.39x39 Structure Structure
TM4 167 K 4.40x40 Structure Structure
TM4 168 R 4.41x41 Structure Structure
TM4 169 A 4.42x42 Structure Structure
TM4 170 R 4.43x43 Structure Structure
TM4 171 N 4.44x44 Structure Structure
TM4 172 S 4.45x45 Structure Structure
TM4 173 I 4.46x46 Structure Structure
TM4 174 V 4.47x47 Structure Structure
TM4 175 I 4.48x48 Structure Structure
TM4 176 I 4.49x49 Structure Structure
TM4 177 W 4.50x50 Structure Structure
TM4 178 I 4.51x51 Structure Structure
TM4 179 V 4.52x52 Structure Structure
TM4 180 S 4.53x53 Structure Structure
TM4 181 C 4.54x54 Structure Structure
TM4 182 I 4.55x55 Structure Structure
TM4 183 I 4.56x56 Structure Structure
TM4 184 M 4.57x57 Structure Structure
TM4 185 I 4.58x59 Structure Structure
TM4 186 P 4.59x60 Structure Structure
TM4 187 Q 4.60x61 Structure Structure
TM4 188 A 4.61x62 Structure Structure
TM4 189 I 4.62x63 Structure Structure
TM4 190 V 4.63x64 Structure Structure
TM4 191 M 4.64x65 Structure Structure
ECL2 192 E - Structure Structure
ECL2 193 C - Structure Structure
ECL2 194 S - Structure Structure
ECL2 195 T - AF2 AF2
ECL2 196 V - AF2 AF2
ECL2 197 F - AF2 AF2
ECL2 198 P - AF2 AF2
ECL2 199 G - AF2 AF2
ECL2 200 L - AF2 AF2
ECL2 201 A - AF2 AF2
ECL2 202 N - AF2 AF2
ECL2 203 K - AF2 AF2
ECL2 204 T - AF2 AF2
ECL2 205 T - AF2 AF2
ECL2 206 L - AF2 AF2
ECL2 207 F - AF2 AF2
ECL2 208 T - Structure Structure
ECL2 209 V - Structure Structure
ECL2 210 C 45.50x50 Structure Structure
ECL2 211 D 45.51x51 Structure Structure
ECL2 212 E 45.52x52 Structure Structure
ECL2 213 R - Structure AF2
ECL2 214 W - Structure Structure
ECL2 215 G - Structure Structure
ECL2 216 G - Structure Structure
ECL2 217 E - Structure Structure
TM5 218 I 5.33x34 Structure Structure
TM5 219 Y 5.34x35 Structure Structure
TM5 220 P 5.35x36 Structure Structure
TM5 221 K 5.36x37 Structure Structure
TM5 222 M 5.37x38 Structure Structure
TM5 223 Y 5.38x39 Structure Structure
TM5 224 H 5.39x40 Structure Structure
TM5 225 I 5.40x41 Structure Structure
TM5 226 C 5.41x42 Structure Structure
TM5 227 F 5.42x43 Structure Structure
TM5 228 F 5.43x44 Structure Structure
TM5 229 L 5.44x45 Structure Structure
TM5 230 V 5.45x46 Structure Structure
TM5 231 T 5.46x461 Structure Structure
TM5 232 Y 5.47x47 Structure Structure
TM5 233 M 5.48x48 Structure Structure
TM5 234 A 5.49x49 Structure Structure
TM5 235 P 5.50x50 Structure Structure
TM5 236 L 5.51x51 Structure Structure
TM5 237 C 5.52x52 Structure Structure
TM5 238 L 5.53x53 Structure Structure
TM5 239 M 5.54x54 Structure Structure
TM5 240 V 5.55x55 Structure Structure
TM5 241 L 5.56x56 Structure Structure
TM5 242 A 5.57x57 Structure Structure
TM5 243 Y 5.58x58 Structure Structure
TM5 244 L 5.59x59 Structure Structure
TM5 245 Q 5.60x60 Structure Structure
TM5 246 I 5.61x61 Structure Structure
TM5 247 F 5.62x62 Structure Structure
TM5 248 R 5.63x63 Structure Structure
TM5 249 K 5.64x64 Structure Structure
TM5 250 L 5.65x65 Structure Structure
TM5 251 W 5.66x66 Structure Structure
TM5 252 C 5.67x67 Structure Structure
TM5 253 R 5.68x68 Structure AF2
TM5 254 Q 5.69x69 Structure Structure
TM5 255 I 5.70x70 Structure Structure
TM5 256 P 5.71x71 AF2 AF2
ICL3 257 G - AF2 AF2
ICL3 258 T - AF2 AF2
ICL3 259 S - AF2 AF2
ICL3 260 S - AF2 AF2
ICL3 261 V - AF2 AF2
ICL3 262 V - AF2 AF2
ICL3 263 Q - AF2 AF2
ICL3 282 T - AF2 AF2
ICL3 283 K - AF2 AF2
ICL3 284 S - AF2 AF2
ICL3 285 R - AF2 AF2
ICL3 286 M - AF2 AF2
ICL3 287 S - AF2 AF2
ICL3 288 A - AF2 AF2
TM6 289 V 6.20x20 AF2 AF2
TM6 290 A 6.21x21 AF2 AF2
TM6 291 A 6.22x22 AF2 AF2
TM6 292 E 6.23x23 AF2 AF2
TM6 293 I 6.24x24 Structure Structure
TM6 294 K 6.25x25 Structure AF2
TM6 295 Q 6.26x26 Structure AF2
TM6 296 I 6.27x27 Structure Structure
TM6 297 R 6.28x28 Structure Structure
TM6 298 A 6.29x29 Structure Structure
TM6 299 R 6.30x30 Structure AF2
TM6 300 R 6.31x31 Structure Structure
TM6 301 K 6.32x32 Structure Structure
TM6 302 T 6.33x33 Structure Structure
TM6 303 A 6.34x34 Structure Structure
TM6 304 R 6.35x35 Structure Structure
TM6 305 M 6.36x36 Structure Structure
TM6 306 L 6.37x37 Structure Structure
TM6 307 M 6.38x38 Structure Structure
TM6 308 I 6.39x39 Structure AF2
TM6 309 V 6.40x40 Structure Structure
TM6 310 L 6.41x41 Structure Structure
TM6 311 L 6.42x42 Structure Structure
TM6 312 V 6.43x43 Structure Structure
TM6 313 F 6.44x44 Structure Structure
TM6 314 A 6.45x45 Structure Structure
TM6 315 I 6.46x46 Structure Structure
TM6 316 C 6.47x47 Structure Structure
TM6 317 Y 6.48x48 Structure Structure
TM6 318 L 6.49x49 Structure Structure
TM6 319 P 6.50x50 Structure Structure
TM6 320 I 6.51x51 Structure Structure
TM6 321 S 6.52x52 Structure Structure
TM6 322 I 6.53x53 Structure Structure
TM6 323 L 6.54x54 Structure Structure
TM6 324 N 6.55x55 Structure Structure
TM6 325 V 6.56x56 Structure Structure
TM6 326 L 6.57x57 Structure Structure
TM6 327 K 6.58x58 Structure Structure
TM6 328 R 6.59x59 Structure Structure
TM6 329 V 6.60x60 Structure Structure
TM6 330 F 6.61x61 Structure Structure
ECL3 331 G - Structure Structure
ECL3 332 M - Structure Structure
ECL3 333 F - Structure Structure
ECL3 334 A - AF2 AF2
ECL3 335 H - AF2 AF2
ECL3 336 T - AF2 AF2
ECL3 337 E - AF2 AF2
TM7 338 D 7.27x26 AF2 AF2
TM7 339 R 7.28x27 Structure AF2
TM7 340 E 7.29x28 Structure Structure
TM7 341 T 7.30x29 Structure Structure
TM7 342 V 7.31x30 Structure Structure
TM7 343 Y 7.32x31 Structure Structure
TM7 344 A 7.33x32 Structure Structure
TM7 345 W 7.34x33 Structure Structure
TM7 346 F 7.35x34 Structure Structure
TM7 347 T 7.36x35 Structure Structure
TM7 348 F 7.37x36 Structure Structure
TM7 349 S 7.38x37 Structure Structure
TM7 350 H 7.39x38 Structure Structure
TM7 351 W 7.40x39 Structure Structure
TM7 352 L 7.41x40 Structure Structure
TM7 353 V 7.42x41 Structure Structure
TM7 354 Y 7.43x42 Structure Structure
TM7 355 A 7.44x43 Structure Structure
TM7 356 N 7.45x45 Structure Structure
TM7 357 S 7.46x46 Structure Structure
TM7 358 A 7.47x47 Structure Structure
TM7 359 A 7.48x48 Structure Structure
TM7 360 N 7.49x49 Structure Structure
TM7 361 P 7.50x50 Structure Structure
TM7 362 I 7.51x51 Structure Structure
TM7 363 I 7.52x52 Structure Structure
TM7 364 Y 7.53x53 Structure Structure
TM7 365 N 7.54x54 Structure Structure
TM7 366 F 7.55x55 Structure Structure
TM7 367 L 7.56x56 Structure Structure
H8 368 S 8.47x47 Structure Structure
H8 369 G 8.48x48 Structure Structure
H8 370 K 8.49x49 Structure Structure
H8 371 F 8.50x50 Structure Structure
H8 372 R 8.51x51 Structure Structure
H8 373 E 8.52x52 Structure AF2
H8 374 E 8.53x53 Structure AF2
H8 375 F 8.54x54 Structure Structure
H8 376 K 8.55x55 Structure AF2
H8 377 A 8.56x56 Structure Structure
H8 378 A 8.57x57 Structure Structure
H8 379 F 8.58x58 Structure Structure
H8 380 S 8.59x59 AF2 AF2
H8 381 C 8.60x60 AF2 AF2
H8 382 C 8.61x61 AF2 AF2
H8 383 C 8.62x62 AF2 AF2
H8 384 L 8.63x63 AF2 AF2
C-term 385 G - AF2 AF2
C-term 386 V - AF2 AF2
C-term 387 H - AF2 AF2
C-term 388 H - AF2 AF2
C-term 389 R - AF2 AF2
C-term 390 Q - AF2 AF2
C-term 391 E - AF2 AF2
C-term 392 D - AF2 AF2
C-term 393 R - AF2 AF2
C-term 394 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 301 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 159 34x50 G.H5 I 343 G.H5.15
Polar TM6 T 302 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 302 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 302 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM2 T 89 2x39 G.H5 D 350 G.H5.22
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 156 3x54 G.H5 N 347 G.H5.19
Polar TM5 I 255 5x70 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 255 5x70 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 255 5x70 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 254 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 156 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 298 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 298 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 M 305 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 305 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 160 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 P 256 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 P 256 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 I 255 5x70 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 I 255 5x70 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 160 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 P 256 5x71 G.S6 Y 320 G.S6.02
Van-der-waals TM5 P 256 5x71 G.S6 Y 320 G.S6.02
Hydrophobic TM5 P 256 5x71 G.H5 A 338 G.H5.10
Van-der-waals TM5 P 256 5x71 G.H5 A 338 G.H5.10
Hydrophobic ICL2 F 162 34x53 G.S3 L 194 G.S3.01
Polar TM5 P 256 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 P 256 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 P 256 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 301 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 301 6x32 G.H5 F 354 G.H5.26
Polar TM3 A 155 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 155 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM2 T 89 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 159 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 159 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 160 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 160 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 R 152 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 V 261 - G.H4 A 301 G.H4.08
Hydrophobic H8 S 368 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 K 249 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 249 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 160 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 A 155 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 155 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 302 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 302 6x33 G.H5 F 354 G.H5.26
Ionic TM6 K 294 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 294 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 294 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 294 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 299 6x30 G.H5 F 354 G.H5.26
Polar ICL2 M 161 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 161 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 G 257 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 G 257 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 F 162 34x53 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 255 5x70 G.S6 Y 320 G.S6.02
Van-der-waals TM5 I 255 5x70 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 F 162 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 306 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 306 6x37 G.H5 L 353 G.H5.25