Refined structure (7TRS) of Gi1 - M4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-19

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 223 from structure (63.0%), 131 from model (37.0%)
Residue sidechains - 206 from structure (58.2%), 148 from model (41.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure AF2
G.s4h3 237 D G.s4h3.11 Structure AF2
G.s4h3 238 E G.s4h3.12 Structure AF2
G.s4h3 239 E G.s4h3.13 Structure AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (79.8%), 68 from model (20.2%)
Residue sidechains - 264 from structure (78.3%), 73 from model (21.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 N - AF2 AF2
N-term 4 F - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 V - AF2 AF2
N-term 8 N - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 Q - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 V - AF2 AF2
N-term 17 R - AF2 AF2
N-term 18 L - AF2 AF2
N-term 19 V - AF2 AF2
N-term 20 T - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 H - AF2 AF2
N-term 25 N - AF2 AF2
TM1 26 R 1.26x26 AF2 AF2
TM1 27 Y 1.27x27 AF2 AF2
TM1 28 E 1.28x28 AF2 AF2
TM1 29 T 1.29x29 AF2 AF2
TM1 30 V 1.30x30 AF2 AF2
TM1 31 E 1.31x31 AF2 AF2
TM1 32 M 1.32x32 AF2 AF2
TM1 33 V 1.33x33 Structure Structure
TM1 34 F 1.34x34 Structure AF2
TM1 35 I 1.35x35 Structure Structure
TM1 36 A 1.36x36 Structure Structure
TM1 37 T 1.37x37 Structure Structure
TM1 38 V 1.38x38 Structure Structure
TM1 39 T 1.39x39 Structure Structure
TM1 40 G 1.40x40 Structure Structure
TM1 41 S 1.41x41 Structure Structure
TM1 42 L 1.42x42 Structure Structure
TM1 43 S 1.43x43 Structure Structure
TM1 44 L 1.44x44 Structure Structure
TM1 45 V 1.45x45 Structure Structure
TM1 46 T 1.46x46 Structure Structure
TM1 47 V 1.47x47 Structure Structure
TM1 48 V 1.48x48 Structure Structure
TM1 49 G 1.49x49 Structure Structure
TM1 50 N 1.50x50 Structure Structure
TM1 51 I 1.51x51 Structure Structure
TM1 52 L 1.52x52 Structure Structure
TM1 53 V 1.53x53 Structure Structure
TM1 54 M 1.54x54 Structure Structure
TM1 55 L 1.55x55 Structure Structure
TM1 56 S 1.56x56 Structure Structure
TM1 57 I 1.57x57 Structure Structure
TM1 58 K 1.58x58 Structure Structure
TM1 59 V 1.59x59 Structure Structure
TM1 60 N 1.60x60 Structure Structure
ICL1 61 R 12.48x48 Structure AF2
ICL1 62 Q 12.49x49 Structure Structure
ICL1 63 L 12.50x50 Structure Structure
ICL1 64 Q 12.51x51 Structure Structure
TM2 65 T 2.37x37 Structure Structure
TM2 66 V 2.38x38 Structure Structure
TM2 67 N 2.39x39 Structure Structure
TM2 68 N 2.40x40 Structure Structure
TM2 69 Y 2.41x41 Structure Structure
TM2 70 F 2.42x42 Structure Structure
TM2 71 L 2.43x43 Structure Structure
TM2 72 F 2.44x44 Structure Structure
TM2 73 S 2.45x45 Structure Structure
TM2 74 L 2.46x46 Structure Structure
TM2 75 A 2.47x47 Structure Structure
TM2 76 C 2.48x48 Structure Structure
TM2 77 A 2.49x49 Structure Structure
TM2 78 D 2.50x50 Structure Structure
TM2 79 L 2.51x51 Structure Structure
TM2 80 I 2.52x52 Structure Structure
TM2 81 I 2.53x53 Structure Structure
TM2 82 G 2.54x54 Structure Structure
TM2 83 A 2.55x55 Structure Structure
TM2 84 F 2.56x551 Structure Structure
TM2 85 S 2.57x56 Structure Structure
TM2 86 M 2.58x57 Structure Structure
TM2 87 N 2.59x58 Structure Structure
TM2 88 L 2.60x59 Structure Structure
TM2 89 Y 2.61x60 Structure Structure
TM2 90 T 2.62x61 Structure Structure
TM2 91 V 2.63x62 Structure Structure
TM2 92 Y 2.64x63 Structure Structure
TM2 93 I 2.65x64 Structure Structure
TM2 94 I 2.66x65 Structure Structure
TM2 95 K 2.67x66 Structure Structure
TM2 96 G 2.68x67 Structure Structure
ECL1 97 Y 23.49x49 Structure Structure
ECL1 98 W 23.50x50 Structure Structure
ECL1 99 P 23.51x51 Structure Structure
ECL1 100 L 23.52x52 Structure Structure
TM3 101 G 3.21x21 Structure Structure
TM3 102 A 3.22x22 Structure Structure
TM3 103 V 3.23x23 Structure Structure
TM3 104 V 3.24x24 Structure Structure
TM3 105 C 3.25x25 Structure Structure
TM3 106 D 3.26x26 Structure Structure
TM3 107 L 3.27x27 Structure Structure
TM3 108 W 3.28x28 Structure Structure
TM3 109 L 3.29x29 Structure Structure
TM3 110 A 3.30x30 Structure Structure
TM3 111 L 3.31x31 Structure Structure
TM3 112 D 3.32x32 Structure Structure
TM3 113 Y 3.33x33 Structure Structure
TM3 114 V 3.34x34 Structure Structure
TM3 115 V 3.35x35 Structure Structure
TM3 116 S 3.36x36 Structure Structure
TM3 117 N 3.37x37 Structure Structure
TM3 118 A 3.38x38 Structure Structure
TM3 119 S 3.39x39 Structure Structure
TM3 120 V 3.40x40 Structure Structure
TM3 121 M 3.41x41 Structure Structure
TM3 122 N 3.42x42 Structure Structure
TM3 123 L 3.43x43 Structure Structure
TM3 124 L 3.44x44 Structure Structure
TM3 125 I 3.45x45 Structure Structure
TM3 126 I 3.46x46 Structure Structure
TM3 127 S 3.47x47 Structure Structure
TM3 128 F 3.48x48 Structure Structure
TM3 129 D 3.49x49 Structure Structure
TM3 130 R 3.50x50 Structure Structure
TM3 131 Y 3.51x51 Structure Structure
TM3 132 F 3.52x52 Structure Structure
TM3 133 C 3.53x53 Structure Structure
TM3 134 V 3.54x54 Structure Structure
TM3 135 T 3.55x55 Structure Structure
TM3 136 K 3.56x56 Structure Structure
ICL2 137 P 34.50x50 Structure Structure
ICL2 138 L 34.51x51 Structure Structure
ICL2 139 T 34.52x52 Structure Structure
ICL2 140 Y 34.53x53 Structure Structure
ICL2 141 P 34.54x54 Structure Structure
ICL2 142 A 34.55x55 Structure Structure
ICL2 143 R 34.56x56 Structure Structure
ICL2 144 R 34.57x57 Structure Structure
TM4 145 T 4.38x38 Structure Structure
TM4 146 T 4.39x39 Structure Structure
TM4 147 K 4.40x40 Structure Structure
TM4 148 M 4.41x41 Structure Structure
TM4 149 A 4.42x42 Structure Structure
TM4 150 G 4.43x43 Structure Structure
TM4 151 L 4.44x44 Structure Structure
TM4 152 M 4.45x45 Structure Structure
TM4 153 I 4.46x46 Structure Structure
TM4 154 A 4.47x47 Structure Structure
TM4 155 A 4.48x48 Structure Structure
TM4 156 A 4.49x49 Structure Structure
TM4 157 W 4.50x50 Structure Structure
TM4 158 V 4.51x51 Structure Structure
TM4 159 L 4.52x52 Structure Structure
TM4 160 S 4.53x53 Structure Structure
TM4 161 F 4.54x54 Structure Structure
TM4 162 V 4.55x55 Structure Structure
TM4 163 L 4.56x56 Structure Structure
TM4 164 W 4.57x57 Structure Structure
TM4 165 A 4.58x58 Structure Structure
TM4 166 P 4.59x59 Structure Structure
TM4 167 A 4.60x60 Structure Structure
TM4 168 I 4.61x61 Structure Structure
TM4 169 L 4.62x62 Structure Structure
TM4 170 F 4.63x63 Structure Structure
TM4 171 W 4.64x64 Structure Structure
TM4 172 Q 4.65x65 Structure Structure
TM4 173 F 4.66x66 Structure Structure
TM4 174 V 4.67x67 Structure Structure
TM4 175 V 4.68x68 Structure Structure
TM4 176 G 4.69x69 Structure Structure
ECL2 177 K - Structure Structure
ECL2 178 R - Structure Structure
ECL2 179 T - Structure Structure
ECL2 180 V - Structure Structure
ECL2 181 P - Structure Structure
ECL2 182 D - Structure Structure
ECL2 183 N - Structure Structure
ECL2 184 Q - Structure Structure
ECL2 185 C 45.50x50 Structure Structure
ECL2 186 F 45.51x51 Structure Structure
ECL2 187 I 45.52x52 Structure Structure
ECL2 188 Q - Structure Structure
ECL2 189 F - Structure Structure
ECL2 190 L - Structure Structure
ECL2 191 S - Structure Structure
TM5 192 N 5.35x36 Structure Structure
TM5 193 P 5.36x37 Structure Structure
TM5 194 A 5.37x38 Structure Structure
TM5 195 V 5.38x39 Structure Structure
TM5 196 T 5.39x40 Structure Structure
TM5 197 F 5.40x41 Structure Structure
TM5 198 G 5.41x42 Structure Structure
TM5 199 T 5.42x43 Structure Structure
TM5 200 A 5.43x44 Structure Structure
TM5 201 I 5.44x45 Structure Structure
TM5 202 A 5.45x46 Structure Structure
TM5 203 A 5.46x461 Structure Structure
TM5 204 F 5.47x47 Structure Structure
TM5 205 Y 5.48x48 Structure Structure
TM5 206 L 5.49x49 Structure Structure
TM5 207 P 5.50x50 Structure Structure
TM5 208 V 5.51x51 Structure Structure
TM5 209 V 5.52x52 Structure Structure
TM5 210 I 5.53x53 Structure Structure
TM5 211 M 5.54x54 Structure Structure
TM5 212 T 5.55x55 Structure Structure
TM5 213 V 5.56x56 Structure Structure
TM5 214 L 5.57x57 Structure Structure
TM5 215 Y 5.58x58 Structure Structure
TM5 216 I 5.59x59 Structure Structure
TM5 217 H 5.60x60 Structure Structure
TM5 218 I 5.61x61 Structure Structure
TM5 219 S 5.62x62 Structure Structure
TM5 220 L 5.63x63 Structure Structure
TM5 221 A 5.64x64 Structure Structure
TM5 222 S 5.65x65 Structure Structure
TM5 223 R 5.66x66 Structure Structure
TM5 224 S 5.67x67 Structure Structure
TM5 225 R 5.68x68 Structure Structure
TM5 226 V 5.69x69 Structure Structure
TM5 227 H 5.70x70 AF2 AF2
TM5 228 K 5.71x71 AF2 AF2
TM5 229 H 5.72x72 AF2 AF2
TM5 230 R 5.73x73 AF2 AF2
TM5 231 P 5.74x74 AF2 AF2
TM5 232 E 5.75x75 AF2 AF2
ICL3 233 G - AF2 AF2
ICL3 234 P - AF2 AF2
ICL3 235 K - AF2 AF2
ICL3 236 E - AF2 AF2
ICL3 237 K - AF2 AF2
ICL3 238 K - AF2 AF2
ICL3 239 A - AF2 AF2
ICL3 382 R - AF2 AF2
ICL3 383 N - AF2 AF2
ICL3 384 Q - AF2 AF2
ICL3 385 V - AF2 AF2
ICL3 386 R - AF2 AF2
ICL3 387 K - AF2 AF2
ICL3 388 K - AF2 AF2
TM6 389 R 6.24x24 AF2 AF2
TM6 390 Q 6.25x25 AF2 AF2
TM6 391 M 6.26x26 AF2 AF2
TM6 392 A 6.27x27 Structure Structure
TM6 393 A 6.28x28 Structure Structure
TM6 394 R 6.29x29 Structure Structure
TM6 395 E 6.30x30 Structure Structure
TM6 396 R 6.31x31 Structure Structure
TM6 397 K 6.32x32 Structure Structure
TM6 398 V 6.33x33 Structure Structure
TM6 399 T 6.34x34 Structure Structure
TM6 400 R 6.35x35 Structure Structure
TM6 401 T 6.36x36 Structure Structure
TM6 402 I 6.37x37 Structure Structure
TM6 403 F 6.38x38 Structure Structure
TM6 404 A 6.39x39 Structure Structure
TM6 405 I 6.40x40 Structure Structure
TM6 406 L 6.41x41 Structure Structure
TM6 407 L 6.42x42 Structure Structure
TM6 408 A 6.43x43 Structure Structure
TM6 409 F 6.44x44 Structure Structure
TM6 410 I 6.45x45 Structure Structure
TM6 411 L 6.46x46 Structure Structure
TM6 412 T 6.47x47 Structure Structure
TM6 413 W 6.48x48 Structure Structure
TM6 414 T 6.49x49 Structure Structure
TM6 415 P 6.50x50 Structure Structure
TM6 416 Y 6.51x51 Structure Structure
TM6 417 N 6.52x52 Structure Structure
TM6 418 V 6.53x53 Structure Structure
TM6 419 M 6.54x54 Structure Structure
TM6 420 V 6.55x55 Structure Structure
TM6 421 L 6.56x56 Structure Structure
TM6 422 V 6.57x57 Structure Structure
TM6 423 N 6.58x58 Structure Structure
TM6 424 T 6.59x59 Structure Structure
TM6 425 F 6.60x60 Structure Structure
TM6 426 C 6.61x61 Structure Structure
ECL3 427 Q - Structure AF2
ECL3 428 S - Structure Structure
ECL3 429 C - Structure Structure
ECL3 430 I - Structure Structure
TM7 431 P 7.31x30 Structure Structure
TM7 432 D 7.32x31 Structure Structure
TM7 433 T 7.33x32 Structure Structure
TM7 434 V 7.34x33 Structure Structure
TM7 435 W 7.35x34 Structure Structure
TM7 436 S 7.36x35 Structure Structure
TM7 437 I 7.37x36 Structure Structure
TM7 438 G 7.38x37 Structure Structure
TM7 439 Y 7.39x38 Structure Structure
TM7 440 W 7.40x39 Structure Structure
TM7 441 L 7.41x40 Structure Structure
TM7 442 C 7.42x41 Structure Structure
TM7 443 Y 7.43x42 Structure Structure
TM7 444 V 7.44x43 Structure Structure
TM7 445 N 7.45x45 Structure Structure
TM7 446 S 7.46x46 Structure Structure
TM7 447 T 7.47x47 Structure Structure
TM7 448 I 7.48x48 Structure Structure
TM7 449 N 7.49x49 Structure Structure
TM7 450 P 7.50x50 Structure Structure
TM7 451 A 7.51x51 Structure Structure
TM7 452 C 7.52x52 Structure Structure
TM7 453 Y 7.53x53 Structure Structure
TM7 454 A 7.54x54 Structure Structure
TM7 455 L 7.55x55 Structure Structure
TM7 456 C 7.56x56 Structure Structure
H8 457 N 8.47x47 Structure Structure
H8 458 A 8.48x48 Structure Structure
H8 459 T 8.49x49 Structure Structure
H8 460 F 8.50x50 Structure Structure
H8 461 K 8.51x51 Structure Structure
H8 462 K 8.52x52 Structure AF2
H8 463 T 8.53x53 Structure Structure
H8 464 F 8.54x54 Structure Structure
H8 465 R 8.55x55 Structure AF2
H8 466 H 8.56x56 Structure Structure
H8 467 L 8.57x57 AF2 AF2
H8 468 L 8.58x58 AF2 AF2
H8 469 L 8.59x59 AF2 AF2
H8 470 C 8.60x60 AF2 AF2
H8 471 Q 8.61x61 AF2 AF2
C-term 472 Y - AF2 AF2
C-term 473 R - AF2 AF2
C-term 474 N - AF2 AF2
C-term 475 I - AF2 AF2
C-term 476 G - AF2 AF2
C-term 477 T - AF2 AF2
C-term 478 A - AF2 AF2
C-term 479 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 T 401 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 401 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 401 6x36 G.H5 L 353 G.H5.25
Polar ICL3 N 383 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 N 383 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 N 383 - G.H4 Q 304 G.H4.12
Hydrophobic TM3 R 130 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 398 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 V 398 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 226 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 226 5x69 G.H5 D 341 G.H5.13
Ionic C-term R 479 - G.h2s4 E 216 G.h2s4.02
Hydrophobic TM5 I 218 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 218 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 138 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 R 386 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 R 386 - G.h4s6 K 314 G.h4s6.08
Ionic TM6 R 394 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 394 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 394 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 394 6x29 G.H5 D 341 G.H5.13
Polar TM5 S 224 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 224 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 224 5x67 G.H5 D 341 G.H5.13
Polar ICL2 P 137 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 R 394 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL3 P 234 - G.H4 E 298 G.H4.05
Hydrophobic ICL3 P 234 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 P 234 - G.H4 E 297 G.H4.04
Hydrophobic TM6 R 394 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 141 34x54 G.H5 N 347 G.H5.19
Polar TM2 N 67 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 N 67 2x39 G.H5 C 351 G.H5.23
Polar TM6 Q 390 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 R 394 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 394 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 L 138 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 137 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 138 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 137 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 S 222 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 226 5x69 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 226 5x69 G.S6 Y 320 G.S6.02
Polar TM6 K 397 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 397 6x32 G.H5 L 353 G.H5.25
Polar ICL3 R 386 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 R 386 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 R 386 - G.H4 E 308 G.H4.16
Hydrophobic TM3 V 134 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 348 G.H5.20
Polar ICL3 N 383 - G.H4 C 305 G.H4.13
Hydrophobic ICL3 N 383 - G.H4 C 305 G.H4.13
Van-der-waals ICL3 N 383 - G.H4 C 305 G.H4.13
Aromatic TM6 K 397 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 397 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 397 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 C 133 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM7 C 456 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 398 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 398 6x33 G.H5 L 353 G.H5.25
Polar TM6 Q 390 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 Q 390 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 390 6x25 G.h4s6 E 318 G.h4s6.12
Polar TM6 Q 390 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 Q 390 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 Q 390 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 G 233 - G.H4 E 297 G.H4.04
Polar TM3 R 130 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 C 351 G.H5.23
Polar TM3 C 133 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 133 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 133 3x53 G.H5 N 347 G.H5.19