GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	CHEMBL5093342	213778	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	213778	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11329254	84778	0	None	-	1	Guinea pig	5.0	pEC50	=	5	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL225571	84778	0	None	-	1	Guinea pig	5.0	pEC50	=	5	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL5093342	213778	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	213778	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	66	None	-9	28	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	66	None	-9	28	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	66	None	-9	28	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	66	None	-9	28	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	134138168	147146	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147146	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	66	None	-9	28	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	66	None	-9	28	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	66	None	-9	28	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	66	None	-9	28	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	135367816	164272	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164272	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367816	164272	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164272	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	134138168	147146	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147146	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	23643870	92418	0	None	-	1	Guinea pig	5.9	pEC50	=	5.9	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243955	92418	0	None	-	1	Guinea pig	5.9	pEC50	=	5.9	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL5081379	212964	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5081379	212964	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	135367820	164258	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164258	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367820	164258	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164258	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5094493	213713	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5094493	213713	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	92042876	150792	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	150792	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	66	None	-9	28	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	5202	139	66	None	-9	28	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	CHEMBL39	139	66	None	-9	28	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	DB08839	139	66	None	-9	28	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8014553
	92042876	150792	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	150792	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	67268994	163405	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163405	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	67268994	163405	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163405	2	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	163633	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	163633	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	163633	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	163633	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	5	139	66	None	-9	28	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	5202	139	66	None	-9	28	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	CHEMBL39	139	66	None	-9	28	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	DB08839	139	66	None	-9	28	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm500880c
	11385992	84231	0	None	-	1	Guinea pig	4.8	pEC50	=	4.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL222477	84231	0	None	-	1	Guinea pig	4.8	pEC50	=	4.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	23643664	2308	6	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	8434	2308	6	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	CHEMBL243954	2308	6	None	-	1	Guinea pig	5.8	pEC50	=	5.8	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	CHEMBL5094234	213787	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	213787	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5094234	213787	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	213787	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11785183	84275	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222755	84275	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	124247485	163506	7	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	163506	7	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5084249	213123	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	124247485	163506	7	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	163506	7	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5084249	213123	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	24825775	1490	10	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1490	10	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1490	10	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	24825775	1490	10	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1490	10	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1490	10	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	102364516	113031	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321794	113031	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	11282296	142771	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL389718	142771	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	11224758	2311	3	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	8435	2311	3	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	CHEMBL225284	2311	3	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	5	139	66	None	-9	28	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	5202	139	66	None	-9	28	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	CHEMBL39	139	66	None	-9	28	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	DB08839	139	66	None	-9	28	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayAgonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	25107520	187000	0	None	-	1	Guinea pig	6.5	pEC50	=	6.5	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	CHEMBL494709	187000	0	None	-	1	Guinea pig	6.5	pEC50	=	6.5	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	42625440	170236	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL445334	170236	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	92042877	148631	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3943658	148631	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	92042877	148631	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3943658	148631	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	5	139	66	None	-9	28	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	66	None	-9	28	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	66	None	-9	28	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	66	None	-9	28	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	135367857	164041	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164041	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367857	164041	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164041	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	92042876	150792	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	150792	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	92042876	150792	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	150792	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	5	139	66	None	-9	28	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	5202	139	66	None	-9	28	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	CHEMBL39	139	66	None	-9	28	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	DB08839	139	66	None	-9	28	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	134138168	147146	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147146	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	66	None	-9	28	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	5202	139	66	None	-9	28	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	CHEMBL39	139	66	None	-9	28	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	DB08839	139	66	None	-9	28	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b00642
	134138168	147146	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147146	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	25107648	186630	0	None	-	1	Guinea pig	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	CHEMBL492480	186630	0	None	-	1	Guinea pig	6.3	pEC50	=	6.3	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	1809	134	28	None	-194	9	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	4	134	28	None	-194	9	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	CHEMBL18840	134	28	None	-194	9	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112709
	5	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5202	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	CHEMBL39	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	DB08839	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5202	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	CHEMBL39	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	DB08839	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	92042876	150792	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3961059	150792	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	92042876	150792	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3961059	150792	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL5074190	212533	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	212533	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5083607	213091	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	135453290	133070	23	None	-2818	8	Human	5.3	pEC50	=	5.3	Functional	Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133070	23	None	-2818	8	Human	5.3	pEC50	=	5.3	Functional	Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL5083607	213091	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	118709756	113035	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321798	113035	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	25107716	2309	35	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	8436	2309	35	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	CHEMBL522691	2309	35	None	-	1	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	1809	134	28	None	-194	9	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4	134	28	None	-194	9	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	CHEMBL18840	134	28	None	-194	9	Human	6.2	pEC50	=	6.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	1809	134	28	None	-2137	9	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	4	134	28	None	-2137	9	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	CHEMBL18840	134	28	None	-2137	9	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	1809	134	28	None	-2137	9	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	4	134	28	None	-2137	9	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	CHEMBL18840	134	28	None	-2137	9	Guinea pig	6.2	pEC50	=	6.2	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	11432177	84684	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL224820	84684	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL5083607	213091	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5083607	213091	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	5202	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	CHEMBL39	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	DB08839	139	66	None	-9	28	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	5	139	66	None	-9	28	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	5202	139	66	None	-9	28	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	CHEMBL39	139	66	None	-9	28	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	DB08839	139	66	None	-9	28	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2020.115578
	CHEMBL5091373	213781	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	213781	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	213781	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	213781	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	213781	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	213781	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5091373	213781	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	213781	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	212710	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	212710	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assayAgonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion gene assessed as beta arrestin recruitment incubated for 22 hrs by Tango assay	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074880	212558	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5074880	212558	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11431530	84188	0	None	-	1	Guinea pig	5.1	pEC50	=	5.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL222188	84188	0	None	-	1	Guinea pig	5.1	pEC50	=	5.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	24825775	1490	10	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1490	10	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1490	10	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	24825775	1490	10	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1490	10	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1490	10	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	212533	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5074190	212533	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	5	139	66	None	-9	28	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	5202	139	66	None	-9	28	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	CHEMBL39	139	66	None	-9	28	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	DB08839	139	66	None	-9	28	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00110
	23643663	92398	0	None	-	1	Guinea pig	6.1	pEC50	=	6.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243744	92398	0	None	-	1	Guinea pig	6.1	pEC50	=	6.1	Functional	Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL5077293	212710	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5077293	212710	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysisAgonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	3233	3443	40	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3443	40	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3443	40	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3443	40	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3443	40	None	8511	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	4106	2456	16	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	5358812	2456	16	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	89	2456	16	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	CHEMBL93240	2456	16	None	-7	7	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2019.126703
	3233	3443	40	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3443	40	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3443	40	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3443	40	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3443	40	None	8511	2	Human	9.1	pIC50	=	9.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3233	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	3247	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	6604889	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	CHEMBL282199	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	DB13988	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2018.04.059
	3233	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3233	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3443	40	None	8511	2	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	4106	2456	16	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	5358812	2456	16	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	89	2456	16	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	CHEMBL93240	2456	16	None	-7	7	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	164609529	183872	0	None	-36	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4846823	183872	0	None	-36	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	11391654	179933	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	179933	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	127028798	137643	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769612	137643	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	142601335	185829	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	185829	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	145946966	167025	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4209888	167025	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300899	167025	0	None	-144	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	142601335	185829	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	185829	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	4106	2456	16	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	5358812	2456	16	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	89	2456	16	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	CHEMBL93240	2456	16	None	-7	7	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112709
	117209912	184745	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	184745	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209912	184745	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	184745	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	135339817	180892	0	None	-1	5	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	CHEMBL4764679	180892	0	None	-1	5	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	206	2447	10	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	68848	2447	10	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	CHEMBL12314	2447	10	None	-97	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm8014553
	156013673	176677	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4636148	176677	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	127028797	137792	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771309	137792	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	11536844	114611	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	114611	0	None	2	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	213046	2343	55	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	4168	2343	55	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	7461	2343	55	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	CHEMBL1237021	2343	55	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	DB08815	2343	55	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assayAntagonist activity at human 5-HT7A receptor expressed in HEK cell membranes assessed as reduction in serotonin-induced cAMP accumulation incubated for 20 mins by cAMP functional assay	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2021.113243
	142601318	184953	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	184953	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601318	184953	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	184953	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	11500509	120057	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120057	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120057	0	None	3	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	117209962	184276	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184276	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209962	184276	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184276	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601343	185011	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185011	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601343	185011	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185011	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	127029652	137787	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771222	137787	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	145947937	167151	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4207653	167151	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4302655	167151	0	None	-32	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	134141985	146631	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3927929	146631	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	134141985	146631	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3927929	146631	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	44348383	16112	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1016/j.ejmech.2012.11.042
	CHEMBL122536	16112	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1016/j.ejmech.2012.11.042
	4106	2456	16	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	5358812	2456	16	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	89	2456	16	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	CHEMBL93240	2456	16	None	-7	7	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.02.024
	102364516	113031	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321794	113031	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	134157289	153535	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3984812	153535	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	118709756	113035	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321798	113035	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	134157289	153535	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3984812	153535	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	117209857	184545	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	184545	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	184410	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184410	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	145946714	166986	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4213352	166986	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300399	166986	0	None	-30	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	142601328	184410	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184410	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209857	184545	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	184545	1	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127029650	137725	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770581	137725	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	142601333	185171	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185171	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	184410	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184410	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367820	164258	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164258	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601333	185171	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185171	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601328	184410	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184410	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367820	164258	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164258	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	163633	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	163633	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367405	163633	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	163633	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	156010865	176547	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633786	176547	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	71574210	85842	0	None	2	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312934	85842	0	None	2	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	206	2447	10	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	68848	2447	10	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	CHEMBL12314	2447	10	None	-97	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm500880c
	3233	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3247	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	6604889	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	CHEMBL282199	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	DB13988	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3233	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3247	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	6604889	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	CHEMBL282199	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	DB13988	3443	40	None	8511	2	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	2470	3583	46	None	-5128	11	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	3300	3583	46	None	-5128	11	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	5265	3583	46	None	-5128	11	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	99	3583	46	None	-5128	11	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	CHEMBL267930	3583	46	None	-5128	11	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2020.115578
	127028473	137732	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770639	137732	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	86288948	112116	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3233679	112116	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3302600	112116	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	71574302	85823	0	None	-4	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312637	85823	0	None	-4	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	142601323	185249	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185249	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	135367816	164272	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164272	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	117209971	185893	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	185893	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367816	164272	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164272	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601323	185249	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185249	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	117209971	185893	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	185893	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209918	185818	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	185818	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209918	185818	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	185818	1	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	11536843	114612	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	114612	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	22001618	81387	6	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164336	81387	6	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	59511191	184931	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	184931	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	59511191	184931	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	184931	3	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	2737389	186993	23	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL494675	186993	23	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	90656694	110493	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262428	110493	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	117209911	185737	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	185737	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	117209911	185737	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	185737	1	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	134154531	152184	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3973160	152184	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	71574306	85825	0	None	2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312639	85825	0	None	2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	134154531	152184	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3973160	152184	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	145947560	167136	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4212812	167136	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4302457	167136	0	None	-19	4	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	11694810	120015	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120015	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120015	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	127028153	137622	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769441	137622	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	142601325	185277	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185277	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601325	185277	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185277	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	117209964	185542	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	185542	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	134137104	142148	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3892079	142148	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	134137104	142148	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3892079	142148	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	117209964	185542	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	185542	1	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	155510732	168942	0	None	1	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	430	6	1	1	6.9	Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4434876	168942	0	None	1	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis	ChEMBL	430	6	1	1	6.9	Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126703
	142601329	185925	3	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	185925	3	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601329	185925	3	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	185925	3	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	124247485	163506	7	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	163506	7	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	124247485	163506	7	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	163506	7	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	142601337	185378	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185378	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601337	185378	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185378	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601335	185829	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	185829	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	142601335	185829	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	185829	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in beta-arrestin recruitment incubated for 22 hrs by bright-Glo reagent based Tango assay	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	67268994	163405	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163405	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	67268994	163405	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163405	2	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	71574212	85843	0	None	-4	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312935	85843	0	None	-4	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	127028472	137630	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769534	137630	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	71574204	85826	0	None	18	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	CHEMBL2312640	85826	0	None	18	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	135367857	164041	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164041	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135367857	164041	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164041	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	117209864	185442	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	185442	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209864	185442	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	185442	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209965	184655	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	184655	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601341	184780	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	184780	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209965	184655	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	184655	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601341	184780	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	184780	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209858	183961	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	183961	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	117209858	183961	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	183961	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysisAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as reduction in cAMP accumulation incubated for 30 mins by microplate reader analysis	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	3233	3443	40	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3443	40	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3443	40	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3443	40	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3443	40	None	-	2	Guinea pig	8.0	pKd	=	8.0	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3443	40	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3443	40	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3443	40	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3443	40	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3443	40	None	-	2	Guinea pig	7.9	pKd	=	7.9	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3443	40	None	-	2	Guinea pig	7.8	pKd	=	7.8	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	24768520	92561	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL244161	92561	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	3233	3443	40	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3443	40	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3443	40	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3443	40	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3443	40	None	-	2	Guinea pig	7.7	pKd	=	7.7	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3443	40	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3443	40	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3443	40	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3443	40	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3443	40	None	-	2	Guinea pig	8.4	pKd	=	8.4	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3247	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	6604889	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	CHEMBL282199	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	DB13988	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm800615e
	3233	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3443	40	None	-	2	Guinea pig	7.5	pKd	=	7.5	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3443	40	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3443	40	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3443	40	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3443	40	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3443	40	None	-	2	Guinea pig	8.2	pKd	=	8.2	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3233	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	3247	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	6604889	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	CHEMBL282199	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	DB13988	3443	40	None	-	2	Guinea pig	8.1	pKd	=	8.1	Functional	Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm070487n
	118731356	117676	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409039	117676	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	4806	3933	85	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	7351	3933	85	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	9966051	3933	85	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	CHEMBL2104993	3933	85	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	DB09068	3933	85	None	-	3	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assayAntagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	118731351	117672	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409035	117672	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAgonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	118731356	117676	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409039	117676	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	118731351	117672	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409035	117672	0	None	-	0	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to controlAntagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF assay relative to control	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	240	929	39	None	-1	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	929	39	None	-1	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	929	39	None	-1	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	929	39	None	-1	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	929	39	None	-1	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	929	39	None	-1	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	929	39	None	-1	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	4223	3917	88	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	3917	88	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	3917	88	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	3917	88	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	3917	88	None	-562	16	Rat	8.3	pIC50	=	8.3	Functional	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	4106	2456	16	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
	5358812	2456	16	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
	89	2456	16	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
	CHEMBL93240	2456	16	None	-4	34	Human	9.2	pEC50	=	9.2	Binding	Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/np058114h
	5	139	66	None	-3	55	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	5202	139	66	None	-3	55	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	CHEMBL39	139	66	None	-3	55	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	DB08839	139	66	None	-3	55	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	5	139	66	None	-3	55	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	5202	139	66	None	-3	55	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	CHEMBL39	139	66	None	-3	55	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	DB08839	139	66	None	-3	55	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2019.07.046
	5	139	66	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
	5202	139	66	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
	CHEMBL39	139	66	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
	DB08839	139	66	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.03.006
	5	139	66	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
	5202	139	66	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
	CHEMBL39	139	66	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
	DB08839	139	66	None	-3	55	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2016.11.014
	5	139	66	None	-3	55	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	5202	139	66	None	-3	55	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	CHEMBL39	139	66	None	-3	55	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	DB08839	139	66	None	-3	55	Human	9.5	pIC50	=	9.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	72548703	161007	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161007	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	5	139	66	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	5202	139	66	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	CHEMBL39	139	66	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	DB08839	139	66	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	5	139	66	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
	5202	139	66	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
	CHEMBL39	139	66	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
	DB08839	139	66	None	-3	55	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2013.03.016
	5	139	66	None	-3	55	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	5202	139	66	None	-3	55	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	CHEMBL39	139	66	None	-3	55	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	DB08839	139	66	None	-3	55	Human	9.2	pIC50	=	9.2	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	5	139	66	None	-3	55	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
	5202	139	66	None	-3	55	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
	CHEMBL39	139	66	None	-3	55	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
	DB08839	139	66	None	-3	55	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm701575k
	11430418	18584	11	None	-	1	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
	CHEMBL1278088	18584	11	None	-	1	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
	44452114	160244	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL411442	160244	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452114	160244	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL411442	160244	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	72197486	102017	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393245	102017	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040361	102017	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	49864602	15473	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	373	5	0	4	3.0	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2010.06.150
	CHEMBL1222138	15473	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	373	5	0	4	3.0	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2010.06.150
	44576978	186679	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.5	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL492793	186679	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.5	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	72197485	102003	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393244	102003	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040288	102003	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	348	4	2	4	3.6	Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	42635388	187105	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	471	8	1	5	3.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL495250	187105	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	471	8	1	5	3.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452277	95620	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260073	95620	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452245	95687	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260514	95687	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	44452251	95775	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	CHEMBL260901	95775	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	44452219	160678	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL411868	160678	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	54576142	66147	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	CHEMBL1852341	66147	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	CHEMBL3216098	66147	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	485	7	1	5	4.7	Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	24882509	95779	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260907	95779	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452277	95620	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260073	95620	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452245	95687	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260514	95687	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	46232586	199228	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	9	0	4	4.6	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL601659	199228	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	9	0	4	4.6	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	44452251	95775	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	CHEMBL260901	95775	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	44452219	160678	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL411868	160678	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	135	2486	38	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	1796	2486	38	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	4184	2486	38	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	CHEMBL6437	2486	38	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	DB06148	2486	38	None	-83	58	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(01)00721-1
	46232818	199286	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL602060	199286	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	11113605	10392	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL116735	10392	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	44451927	95568	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL259776	95568	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452038	95781	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260969	95781	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	155561990	175128	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	557	11	1	7	4.5	CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL4582321	175128	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	557	11	1	7	4.5	CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2019.111705
	24882509	95779	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260907	95779	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	42635204	187166	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL495678	187166	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	46232860	199366	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	494	10	0	6	3.9	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL602677	199366	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	494	10	0	6	3.9	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
	44451927	95568	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL259776	95568	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452038	95781	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260969	95781	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	46232771	199161	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	443	10	0	5	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601249	199161	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	443	10	0	5	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	10067306	197178	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	363	5	0	5	3.1	CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
	CHEMBL584046	197178	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	363	5	0	5	3.1	CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
	46232622	199023	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL600012	199023	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	42635387	187099	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.6	O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL495212	187099	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.6	O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	46232773	199256	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	511	10	0	5	4.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601855	199256	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	511	10	0	5	4.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	44452278	95621	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260074	95621	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452039	95782	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260970	95782	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452278	95621	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260074	95621	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452039	95782	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260970	95782	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44451930	95306	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL258524	95306	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
	44451930	95306	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL258524	95306	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
	10472158	195140	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	335	4	1	5	2.5	NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
	CHEMBL565745	195140	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	335	4	1	5	2.5	NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21	10.1016/j.bmc.2009.05.055
	44452223	95532	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL259625	95532	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	42388965	186942	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL494428	186942	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	44452223	95532	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL259625	95532	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	53320009	56354	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1	10.1016/j.bmcl.2010.12.007
	CHEMBL1642116	56354	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1	10.1016/j.bmcl.2010.12.007
	169713	79736	17	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
	CHEMBL21343	79736	17	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
	11047568	9946	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	396	9	0	4	4.0	CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1	10.1021/jm010878g
	CHEMBL115249	9946	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	396	9	0	4	4.0	CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1	10.1021/jm010878g
	10885636	110514	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL326263	110514	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	46232732	199231	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	431	9	0	4	3.4	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601673	199231	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	431	9	0	4	3.4	O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	44452276	159375	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL410722	159375	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	44452276	159375	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL410722	159375	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	12	1518	14	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
	6918513	1518	14	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
	CHEMBL267615	1518	14	None	-13	7	Human	5.8	pIC50	=	5.8	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1016/j.bmcl.2005.06.067
	46232653	199324	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.8	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602284	199324	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.8	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	46232730	199197	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601457	199197	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	9	0	4	4.5	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	72197484	102008	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393243	102008	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040324	102008	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	18180076	15411	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	381	4	1	4	3.4	CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	CHEMBL1221497	15411	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	381	4	1	4	3.4	CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	44452247	95727	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260706	95727	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452115	95918	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL261742	95918	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	44451980	155468	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL406221	155468	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	44452115	95918	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL261742	95918	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	44451980	155468	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL406221	155468	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	44452247	95727	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260706	95727	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.9	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	46232690	199265	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL601886	199265	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	155568606	175524	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4591601	175524	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	155568606	175524	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4591601	175524	0	None	-3	2	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	11957735	198328	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
	CHEMBL595449	198328	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
	46232589	199119	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	515	11	0	6	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL600822	199119	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	515	11	0	6	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	19426635	203871	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
	CHEMBL81485	203871	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor	ChEMBL	280	2	1	3	3.1	CNCC1CC2c3ccccc3Cc3ccccc3N2O1	10.1016/s0960-894x(01)00721-1
	73351903	89251	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	360	3	2	4	3.1	Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376484	89251	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	360	3	2	4	3.1	Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	46232819	199459	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	493	10	0	5	4.5	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL603272	199459	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	493	10	0	5	4.5	COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	44452166	95352	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL258785	95352	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452166	95352	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL258785	95352	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	543	10	1	7	4.1	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452005	95486	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL259407	95486	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.bmc.2007.11.049
	44451954	159816	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL411105	159816	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452005	95486	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL259407	95486	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
	44451954	159816	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL411105	159816	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232559	199399	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602882	199399	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	505	9	0	4	5.6	O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	44452196	95570	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	CHEMBL259827	95570	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	44451953	95819	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL261149	95819	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	44452080	155224	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL405892	155224	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452144	95840	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261232	95840	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	5	139	66	None	-3	55	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
	5202	139	66	None	-3	55	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
	CHEMBL39	139	66	None	-3	55	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
	DB08839	139	66	None	-3	55	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/np0205102
	3233	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	3247	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	6604889	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	CHEMBL282199	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	DB13988	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	3233	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	3247	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	6604889	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	CHEMBL282199	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	DB13988	3443	40	None	2	12	Human	8.6	pIC50	=	8.6	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2019.07.046
	42388639	187461	0	None	-4	7	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2008.04.023
	CHEMBL497749	187461	0	None	-4	7	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2008.04.023
	44452170	166425	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL428781	166425	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452196	95570	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	CHEMBL259827	95570	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	44451953	95819	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL261149	95819	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	44452080	155224	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL405892	155224	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452144	95840	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL261232	95840	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	51003551	56361	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	449	3	0	5	3.8	CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.12.007
	CHEMBL1642123	56361	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	449	3	0	5	3.8	CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.12.007
	10907460	9720	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL113956	9720	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	49864292	15404	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	471	6	0	4	5.0	CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	CHEMBL1221452	15404	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	471	6	0	4	5.0	CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	49864724	15501	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	409	5	0	4	3.8	CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
	CHEMBL1222364	15501	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	409	5	0	4	3.8	CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
	44452274	95776	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260902	95776	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	44452170	166425	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL428781	166425	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452274	95776	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260902	95776	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	11730467	10910	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL117537	10910	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	155531753	171070	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4465959	171070	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	155531753	171070	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4465959	171070	0	None	-1	2	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	44451929	95604	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260003	95604	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44451929	95604	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260003	95604	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	42635570	186778	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1	10.1016/j.bmc.2008.04.023
	CHEMBL493416	186778	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1	10.1016/j.bmc.2008.04.023
	46232729	199761	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.3	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL604952	199761	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	574	9	0	5	6.3	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	44452139	95750	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.bmc.2007.11.049
	CHEMBL260804	95750	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.bmc.2007.11.049
	44452139	95750	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL260804	95750	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1	10.1016/j.ejmech.2008.09.050
	44452302	95811	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261100	95811	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232689	199264	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	536	10	0	6	5.0	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601885	199264	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	536	10	0	6	5.0	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2009.12.067
	44452302	95811	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261100	95811	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44451957	157938	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL409107	157938	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44451957	157938	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL409107	157938	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	7	3.4	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	11304851	154056	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	426	4	3	8	3.7	O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2	10.1016/j.bmcl.2007.05.011
	CHEMBL399203	154056	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	426	4	3	8	3.7	O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2	10.1016/j.bmcl.2007.05.011
	44452143	95839	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL261231	95839	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452143	95839	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL261231	95839	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	525	10	1	7	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44451952	159814	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	CHEMBL411104	159814	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	44451952	159814	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	CHEMBL411104	159814	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	44452006	156947	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL407966	156947	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452006	156947	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL407966	156947	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452037	95737	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260756	95737	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	44452273	157580	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL408717	157580	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	46866711	15479	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	5	0	4	4.2	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2010.06.150
	CHEMBL1222234	15479	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	5	0	4	4.2	CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2010.06.150
	42388975	192109	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL522006	192109	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452037	95737	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260756	95737	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	44452273	157580	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL408717	157580	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	4106	2456	16	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
	5358812	2456	16	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
	89	2456	16	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
	CHEMBL93240	2456	16	None	-4	34	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2007.11.049
	4223	3917	88	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	6918314	3917	88	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	7427	3917	88	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	CHEMBL439849	3917	88	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	DB06684	3917	88	None	-	3	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/jm040793q
	10131112	1517	21	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
	8428	1517	21	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
	CHEMBL364005	1517	21	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	246	1	2	1	3.5	Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C	10.1016/j.bmcl.2005.06.067
	49864289	15401	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	435	6	0	4	4.2	CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	CHEMBL1221449	15401	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	435	6	0	4	4.2	CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	73347306	89250	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	230	1	2	1	3.0	Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376483	89250	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	230	1	2	1	3.0	Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	46232772	199163	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	11	0	6	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601250	199163	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	473	11	0	6	3.3	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	46232977	199501	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	453	8	1	5	3.7	COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL603499	199501	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	453	8	1	5	3.7	COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	42389293	186941	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL494427	186941	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	439	8	1	5	3.3	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	45278805	7354	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	484	7	1	4	5.2	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C	10.1016/j.bmcl.2010.01.093
	CHEMBL1086754	7354	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	484	7	1	4	5.2	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C	10.1016/j.bmcl.2010.01.093
	46232731	199198	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.3	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601458	199198	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.3	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	42635029	186840	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493810	186840	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	46232820	199158	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	531	9	0	4	5.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL601220	199158	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	531	9	0	4	5.5	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	44452357	95447	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL259236	95447	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	44452118	95893	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261573	95893	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232975	199402	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	482	9	0	5	4.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL602889	199402	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	482	9	0	5	4.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	44452357	95447	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL259236	95447	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452118	95893	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261573	95893	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	549	8	1	6	4.6	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	46232978	199424	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	491	7	1	4	4.7	CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	CHEMBL603093	199424	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	491	7	1	4	4.7	CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	44451931	95307	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL258525	95307	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	11166042	165805	0	None	2	3	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL427518	165805	0	None	2	3	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
	44451931	95307	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL258525	95307	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	73351905	89258	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	288	2	2	1	4.5	Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376491	89258	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	288	2	2	1	4.5	Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	42635571	187167	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	421	8	1	5	2.7	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL495685	187167	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	421	8	1	5	2.7	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	42635572	187204	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	403	8	1	5	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL495890	187204	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	403	8	1	5	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	42635028	192602	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL523519	192602	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	49864723	15500	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	6	0	4	4.2	CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
	CHEMBL1222363	15500	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	423	6	0	4	4.2	CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2010.06.150
	44452329	158180	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL409358	158180	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452329	158180	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL409358	158180	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	45278882	7356	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	512	9	1	4	6.1	CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C	10.1016/j.bmcl.2010.01.093
	CHEMBL1086756	7356	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	512	9	1	4	6.1	CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C	10.1016/j.bmcl.2010.01.093
	46232654	199325	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	506	9	0	5	5.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602285	199325	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	506	9	0	5	5.0	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	44452197	95614	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL260029	95614	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	44452081	95716	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260648	95716	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452008	95487	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL259408	95487	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452197	95614	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL260029	95614	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	44452081	95716	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260648	95716	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452171	168121	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL436700	168121	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	46232691	199266	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	524	9	0	5	5.2	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL601887	199266	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	524	9	0	5	5.2	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	11761059	9941	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	394	4	1	8	3.1	O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2	10.1021/jm010878g
	CHEMBL115229	9941	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	394	4	1	8	3.1	O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2	10.1021/jm010878g
	49864722	15499	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	395	4	0	4	3.4	CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	CHEMBL1222362	15499	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells	ChEMBL	395	4	0	4	3.4	CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1	10.1016/j.bmcl.2010.06.150
	44452328	95622	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260076	95622	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452249	157992	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL409157	157992	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452171	168121	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL436700	168121	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	511	9	1	7	3.6	CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452328	95622	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260076	95622	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	5.1	O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452249	157992	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL409157	157992	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	515	8	1	6	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	46232560	199322	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.5	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602274	199322	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	523	9	0	4	5.5	O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	45109862	7338	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	470	7	2	3	5.2	Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2010.01.093
	CHEMBL1086626	7338	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	470	7	2	3	5.2	Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2010.01.093
	44452222	95490	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	CHEMBL259415	95490	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	44452222	95490	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	CHEMBL259415	95490	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	44452117	95892	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261572	95892	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	42389467	186843	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493816	186843	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	407	8	1	5	2.3	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452217	95396	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL259001	95396	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	44452117	95892	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261572	95892	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	36418162	186969	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	423	8	1	4	3.3	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL494573	186969	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	423	8	1	4	3.3	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	637308	183316	32	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	314	6	2	5	2.9	COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O	10.1021/np050301s
	CHEMBL481245	183316	32	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	314	6	2	5	2.9	COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O	10.1021/np050301s
	10337743	4001	16	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
	8429	4001	16	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
	CHEMBL571858	4001	16	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	347	5	0	5	2.6	CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C	10.1016/j.bmc.2009.05.055
	44452217	95396	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL259001	95396	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	44452007	95441	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL259199	95441	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.ejmech.2008.09.050
	73354882	89249	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	290	1	2	1	3.6	Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376482	89249	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	290	1	2	1	3.6	Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	44452007	95441	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL259199	95441	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1	10.1016/j.bmc.2007.11.049
	46232858	199089	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL600606	199089	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	481	9	0	4	4.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	45278883	7553	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	553	8	1	5	5.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1	10.1016/j.bmcl.2010.01.093
	CHEMBL1088313	7553	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	553	8	1	5	5.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1	10.1016/j.bmcl.2010.01.093
	72197668	102009	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393246	102009	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040325	102009	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins	ChEMBL	360	5	2	5	3.5	COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	44451959	95820	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL261151	95820	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2007.11.049
	44451984	95904	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL261653	95904	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	46232623	199045	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	535	10	0	5	5.6	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	CHEMBL600210	199045	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	535	10	0	5	5.6	COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmc.2009.12.067
	46232770	199147	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	458	10	0	6	3.2	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601037	199147	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	458	10	0	6	3.2	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	44451959	95820	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL261151	95820	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1	10.1016/j.ejmech.2008.09.050
	44451984	95904	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL261653	95904	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	513	7	1	6	4.0	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	44451986	158805	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL410042	158805	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44451986	158805	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL410042	158805	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	501	7	1	6	3.9	O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	10407367	195108	0	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	379	5	0	5	3.6	CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21	10.1016/j.bmc.2009.05.055
	CHEMBL565552	195108	0	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	ChEMBL	379	5	0	5	3.6	CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21	10.1016/j.bmc.2009.05.055
	44452008	95487	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL259408	95487	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	533	8	1	6	4.4	O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	45278886	7554	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	564	8	1	4	6.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1	10.1016/j.bmcl.2010.01.093
	CHEMBL1088314	7554	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	564	8	1	4	6.8	Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1	10.1016/j.bmcl.2010.01.093
	46233014	199323	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	441	7	1	4	3.9	CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	CHEMBL602279	199323	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	441	7	1	4	3.9	CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	42389457	187140	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL495445	187140	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	427	7	1	4	3.5	O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	44452193	95611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260022	95611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	44451982	95865	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	CHEMBL261434	95865	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	16	2213	5	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
	9847194	2213	5	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
	CHEMBL313714	2213	5	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	ChEMBL	462	9	3	6	3.6	OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1	10.1021/jm9910021
	44452193	95611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260022	95611	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	555	11	1	8	4.0	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	44451982	95865	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	CHEMBL261434	95865	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	46700867	175407	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins	ChEMBL	377	14	1	4	5.0	CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1	10.1016/j.ejmech.2019.04.009
	CHEMBL4588956	175407	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins	ChEMBL	377	14	1	4	5.0	CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1	10.1016/j.ejmech.2019.04.009
	42635205	187202	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL495884	187202	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	477	7	1	4	4.3	O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	46232588	199262	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	485	10	0	5	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601872	199262	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	485	10	0	5	4.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	42635389	186776	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	433	9	1	6	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493402	186776	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	433	9	1	6	2.6	COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452275	95777	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	CHEMBL260903	95777	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.bmc.2007.11.049
	44452298	95852	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL261337	95852	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452275	95777	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	CHEMBL260903	95777	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C	10.1016/j.ejmech.2008.09.050
	44452298	95852	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261337	95852	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	46232861	199398	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	532	9	0	5	4.9	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL602878	199398	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	532	9	0	5	4.9	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	54577891	66227	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	CHEMBL1852516	66227	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	CHEMBL3216758	66227	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay	ChEMBL	471	6	1	5	4.3	Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1	10.1021/jm200682b
	44451979	95864	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL261433	95864	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	72198754	90435	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	CHEMBL2392349	90435	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	53320010	56355	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.12.007
	CHEMBL1642117	56355	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells	ChEMBL	435	3	0	5	3.4	CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2010.12.007
	44451979	95864	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL261433	95864	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	185617	185962	82	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	462	4	7	11	-0.2	O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O	10.1021/np0205102
	CHEMBL487805	185962	82	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	462	4	7	11	-0.2	O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O	10.1021/np0205102
	44452279	160729	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL412153	160729	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	44452279	160729	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL412153	160729	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	44452331	95648	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260249	95648	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452331	95648	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260249	95648	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	8	1	6	3.6	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232976	199423	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	423	7	1	4	3.7	CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	CHEMBL603092	199423	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	423	7	1	4	3.7	CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmc.2009.12.067
	10949380	163460	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	399	3	1	6	4.3	Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1	10.1021/jm010878g
	CHEMBL420863	163460	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	399	3	1	6	4.3	Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1	10.1021/jm010878g
	46232620	199142	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	553	10	0	5	5.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601022	199142	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	553	10	0	5	5.5	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	44452010	95531	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL259619	95531	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
	44452141	95792	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL261018	95792	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452010	95531	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL259619	95531	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	6	3.4	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
	44452141	95792	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261018	95792	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	9	1	7	3.9	CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	42389129	192499	2	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	409	7	1	4	3.3	O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	CHEMBL522694	192499	2	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	409	7	1	4	3.3	O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2008.04.023
	73356443	89257	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	294	2	2	2	4.6	Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	CHEMBL2376490	89257	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	294	2	2	2	4.6	Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1	10.1016/j.ejmech.2013.03.006
	44452221	95489	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL259414	95489	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	44452221	95489	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL259414	95489	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	6	4.2	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	44452199	95612	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260023	95612	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	44452199	95612	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL260023	95612	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	11071079	110091	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL325516	110091	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	44452332	95649	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260250	95649	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	44452362	96049	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL262589	96049	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.ejmech.2008.09.050
	44452324	95778	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260906	95778	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452332	95649	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL260250	95649	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	481	7	1	6	3.5	Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452362	96049	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL262589	96049	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	530	8	1	8	3.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1	10.1016/j.bmc.2007.11.049
	44452324	95778	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260906	95778	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452327	95812	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	CHEMBL261102	95812	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	46232859	199090	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	464	9	0	5	3.8	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	CHEMBL600607	199090	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	464	9	0	5	3.8	O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1	10.1016/j.bmc.2009.12.067
	44452327	95812	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	CHEMBL261102	95812	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	10937901	9802	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
	CHEMBL114379	9802	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
	44452040	95783	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL260971	95783	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452041	95827	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261187	95827	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452040	95783	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL260971	95783	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452041	95827	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261187	95827	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	517	8	1	6	3.9	O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452243	157990	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL409156	157990	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.bmc.2007.11.049
	44452243	157990	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL409156	157990	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	559	10	1	8	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1	10.1016/j.ejmech.2008.09.050
	44452224	95533	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL259626	95533	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44452224	95533	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL259626	95533	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	497	8	1	7	3.2	COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	44452246	95726	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL260705	95726	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.ejmech.2008.09.050
	44342270	9822	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	CHEMBL114484	9822	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
	44452246	95726	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL260705	95726	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1	10.1016/j.bmc.2007.11.049
	46232587	199889	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	500	10	0	6	4.4	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL605582	199889	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	500	10	0	6	4.4	O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	46232652	199295	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	573	9	0	4	6.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	CHEMBL602087	199295	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	573	9	0	4	6.6	O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1	10.1016/j.bmc.2009.12.067
	42635027	186804	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493625	186804	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	457	8	1	5	3.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452042	159605	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL410922	159605	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2008.09.050
	44452167	95393	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	CHEMBL258995	95393	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.ejmech.2008.09.050
	44452042	159605	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL410922	159605	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	509	8	1	7	3.4	CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2007.11.049
	44452167	95393	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	CHEMBL258995	95393	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	573	11	1	8	4.2	CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1	10.1016/j.bmc.2007.11.049
	44452142	95793	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261019	95793	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	44452142	95793	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261019	95793	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	567	8	1	6	4.8	O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452359	158807	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	CHEMBL410043	158807	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.bmc.2007.11.049
	44452359	158807	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL410043	158807	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	529	9	1	7	3.8	COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1	10.1016/j.ejmech.2008.09.050
	44452082	158841	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL410075	158841	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	46232817	199260	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	461	10	0	5	3.4	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL601859	199260	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	461	10	0	5	3.4	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1	10.1016/j.bmc.2009.12.067
	44452082	158841	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL410075	158841	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	499	8	1	6	3.7	O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	42389303	186841	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	CHEMBL493811	186841	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	419	9	1	6	2.2	COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1	10.1016/j.bmc.2008.04.023
	44452301	95810	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL261099	95810	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.ejmech.2008.09.050
	44451985	95905	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	CHEMBL261654	95905	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.ejmech.2008.09.050
	44452301	95810	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	CHEMBL261099	95810	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	527	8	1	6	4.4	Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1	10.1016/j.bmc.2007.11.049
	44451985	95905	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	CHEMBL261654	95905	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	467	7	1	6	3.2	O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1	10.1016/j.bmc.2007.11.049
	14748689	186680	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	373	8	1	4	2.2	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/j.bmc.2008.04.023
	CHEMBL492794	186680	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane	ChEMBL	373	8	1	4	2.2	O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/j.bmc.2008.04.023
	44452305	95849	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	CHEMBL261291	95849	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.bmc.2007.11.049
	44452305	95849	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	CHEMBL261291	95849	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	495	7	1	6	3.8	Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C	10.1016/j.ejmech.2008.09.050
	44452078	95382	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.bmc.2007.11.049
	CHEMBL258956	95382	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.bmc.2007.11.049
	44452078	95382	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
	CHEMBL258956	95382	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1	10.1016/j.ejmech.2008.09.050
	44452195	156513	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.ejmech.2008.09.050
	CHEMBL407411	156513	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.ejmech.2008.09.050
	44452195	156513	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.bmc.2007.11.049
	CHEMBL407411	156513	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor	ChEMBL	541	10	1	8	3.6	COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1	10.1016/j.bmc.2007.11.049
	46232621	199917	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	503	10	0	5	4.6	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	CHEMBL605787	199917	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	503	10	0	5	4.6	COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1	10.1016/j.bmc.2009.12.067
	3066250	69928	2	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	242	2	2	2	2.9	COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1	10.1016/j.bmcl.2005.06.067
	CHEMBL194305	69928	2	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human	ChEMBL	242	2	2	2	2.9	COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1	10.1016/j.bmcl.2005.06.067
	11005810	10352	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL116463	10352	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	71061887	92672	0	None	66	2	Human	8.9	pKd	=	8.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442996	92672	0	None	66	2	Human	8.9	pKd	=	8.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	11785183	84275	0	None	-1	5	Human	7.8	pKd	=	7.8	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222755	84275	0	None	-1	5	Human	7.8	pKd	=	7.8	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	11224758	2311	3	None	-4	7	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	8435	2311	3	None	-4	7	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	CHEMBL225284	2311	3	None	-4	7	Human	7.7	pKd	=	7.7	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	11282296	142771	0	None	-6	5	Human	7.6	pKd	=	7.6	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL389718	142771	0	None	-6	5	Human	7.6	pKd	=	7.6	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	5	139	66	None	-3	55	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
	5202	139	66	None	-3	55	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
	CHEMBL39	139	66	None	-3	55	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
	DB08839	139	66	None	-3	55	Human	8.4	pKd	=	8.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.08.023
	1809	134	28	None	-7	37	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4	134	28	None	-7	37	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	CHEMBL18840	134	28	None	-7	37	Human	7.5	pKd	=	7.5	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	11191128	84772	0	None	-5	5	Human	7.2	pKd	=	7.2	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL225512	84772	0	None	-5	5	Human	7.2	pKd	=	7.2	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	11432177	84684	0	None	-1	4	Human	8.0	pKd	=	8.0	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL224820	84684	0	None	-1	4	Human	8.0	pKd	=	8.0	Binding	Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	3233	3443	40	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	3247	3443	40	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	6604889	3443	40	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	CHEMBL282199	3443	40	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	DB13988	3443	40	None	2	12	Human	8.0	pKd	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2011.05.010
	1809	134	28	None	-2	37	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
	4	134	28	None	-2	37	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
	CHEMBL18840	134	28	None	-2	37	Rat	10.5	pKi	=	10.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm9911433
	56944082	111573	0	None	169	4	Human	10.0	pKi	=	10	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	8	1	6	3.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289972	111573	0	None	169	4	Human	10.0	pKi	=	10	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	8	1	6	3.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	5	139	66	None	-3	55	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	5202	139	66	None	-3	55	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	CHEMBL39	139	66	None	-3	55	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	DB08839	139	66	None	-3	55	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2013.01.044
	1809	134	28	None	-2	37	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
	4	134	28	None	-2	37	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
	CHEMBL18840	134	28	None	-2	37	Rat	9.9	pKi	=	9.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030826m
	5	139	66	None	-3	55	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
	5202	139	66	None	-3	55	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
	CHEMBL39	139	66	None	-3	55	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
	DB08839	139	66	None	-3	55	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm2006782
	23643664	2308	6	None	-1	6	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	8434	2308	6	None	-1	6	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	CHEMBL243954	2308	6	None	-1	6	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm070487n
	42631003	197927	10	None	2	8	Human	9.8	pKi	=	9.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.ejmech.2022.114464
	CHEMBL592752	197927	10	None	2	8	Human	9.8	pKi	=	9.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.ejmech.2022.114464
	42631003	197927	10	None	2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1021/acs.jmedchem.7b01898
	CHEMBL592752	197927	10	None	2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1021/acs.jmedchem.7b01898
	168271260	189912	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	432	7	0	5	3.0	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5179460	189912	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	432	7	0	5	3.0	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccccn2)CC1	10.1021/acs.jmedchem.2c00633
	5	139	66	None	-3	55	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	5202	139	66	None	-3	55	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	CHEMBL39	139	66	None	-3	55	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	DB08839	139	66	None	-3	55	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01422
	10450593	123733	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2010.03.012
	CHEMBL363452	123733	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2010.03.012
	10450593	123733	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL363452	123733	0	None	75	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	66801551	111618	0	None	3	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	519	8	1	6	5.6	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3290016	111618	0	None	3	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	519	8	1	6	5.6	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	46224879	199852	3	None	1	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL605405	199852	3	None	1	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	302	2	0	2	4.6	Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	168287666	191054	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5196234	191054	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccccc1F)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
	11224758	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
	8435	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
	CHEMBL225284	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.03.005
	11224758	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
	8435	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
	CHEMBL225284	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.12.041
	11224758	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
	8435	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
	CHEMBL225284	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1016/j.ejmech.2014.08.023
	11224758	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
	8435	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
	CHEMBL225284	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.5b00982
	11224758	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
	8435	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
	CHEMBL225284	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/acs.jmedchem.7b01898
	11224758	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	8435	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	CHEMBL225284	2311	3	None	4	7	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	10.1021/jm049702f
	5	139	66	None	-3	55	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	5202	139	66	None	-3	55	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	CHEMBL39	139	66	None	-3	55	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	DB08839	139	66	None	-3	55	Human	9.7	pKi	=	9.7	Binding	Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm8007618
	10402615	200821	0	None	20	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1021/jm030826m
	CHEMBL611472	200821	0	None	20	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1021/jm030826m
	42631003	197927	10	None	2	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL592752	197927	10	None	2	8	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	304	3	0	2	4.2	Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	145989143	166622	0	None	2	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	399	5	1	2	5.3	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4291322	166622	0	None	2	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	399	5	1	2	5.3	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	44393091	65011	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182923	65011	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393169	65250	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL183277	65250	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	71454999	80996	0	None	169	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159465	80996	0	None	169	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
	1809	134	28	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
	4	134	28	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
	CHEMBL18840	134	28	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm3003679
	46233450	198549	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	357	6	0	1	6.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2010.01.035
	CHEMBL596959	198549	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	357	6	0	1	6.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2010.01.035
	10413595	161280	0	None	-1	11	Human	9.5	pKi	=	9.5	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL414628	161280	0	None	-1	11	Human	9.5	pKi	=	9.5	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	168283786	190266	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5184712	190266	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	465	7	0	4	4.2	O=S(=O)(c1ccc(F)cc1)N1CCC[C@@H]1CCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.2c00633
	3233	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3233	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	3247	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	6604889	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	CHEMBL282199	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	DB13988	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	3233	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3233	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3247	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	6604889	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	CHEMBL282199	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	DB13988	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.1c01093
	3233	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3247	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	6604889	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	CHEMBL282199	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	DB13988	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.07.029
	3233	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	3247	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	6604889	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	CHEMBL282199	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	DB13988	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2016.01.043
	3233	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	3247	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	6604889	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	CHEMBL282199	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	DB13988	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2014.07.026
	3233	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	3247	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	6604889	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	CHEMBL282199	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	DB13988	3443	40	None	2	12	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.8b00642
	1809	134	28	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
	4	134	28	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
	CHEMBL18840	134	28	None	-7	37	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2020.112395
	11524413	95915	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL261719	95915	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	11589069	95787	0	None	10	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
	CHEMBL260994	95787	0	None	10	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
	11524413	95915	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL261719	95915	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	11524413	95915	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL261719	95915	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	44126269	199789	4	None	2	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	CHEMBL605081	199789	4	None	2	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	318	3	0	2	4.5	Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1	10.1016/j.bmcl.2009.11.037
	1809	134	28	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
	4	134	28	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
	CHEMBL18840	134	28	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0341204
	44393073	64117	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL181356	64117	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393092	64234	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL181605	64234	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393193	65295	0	None	32	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL183423	65295	0	None	32	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393192	65906	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL184607	65906	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	2389	3267	114	None	-9	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	5073	3267	114	None	-9	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	96	3267	114	None	-9	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	CHEMBL85	3267	114	None	-9	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	DB00734	3267	114	None	-9	68	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2018.01.002
	145985050	165126	0	None	-3	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4245263	165126	0	None	-3	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	1809	134	28	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
	4	134	28	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
	CHEMBL18840	134	28	None	-7	37	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2013.09.018
	24854273	157815	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL408976	157815	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	56944763	111606	0	None	4	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3290004	111606	0	None	4	4	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	44266163	96595	1	None	4	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	1	2	4.4	O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL267062	96595	1	None	4	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	1	2	4.4	O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(03)00077-5
	24854273	157815	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL408976	157815	0	None	112	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	24854187	95767	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL260872	95767	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	24854187	95767	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL260872	95767	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	132578545	154009	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3898250	154009	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3991133	154009	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	25192947	164103	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
	CHEMBL4216782	164103	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
	25192947	164103	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1021/acs.jmedchem.7b01898
	CHEMBL4216782	164103	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	273	4	1	4	2.5	Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1	10.1021/acs.jmedchem.7b01898
	1809	134	28	None	-7	37	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
	4	134	28	None	-7	37	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
	CHEMBL18840	134	28	None	-7	37	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm0104264
	11653869	95833	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	CHEMBL261209	95833	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	11653869	95833	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
	CHEMBL261209	95833	0	None	134	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
	16362	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	2172	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	90	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	CHEMBL1423	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	DB01100	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1021/jm030030n
	213046	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	4168	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	7461	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	CHEMBL1237021	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	DB08815	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.ejmech.2019.111736
	213046	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	4168	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	7461	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	CHEMBL1237021	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	DB08815	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1016/j.bmc.2020.115459
	132578545	154009	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3898250	154009	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3991133	154009	0	None	33	9	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	325	3	0	2	4.1	O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	66801167	111604	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	CHEMBL3290002	111604	0	None	3	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	1809	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	4	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	CHEMBL18840	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm800615e
	1809	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	4	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	CHEMBL18840	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm070487n
	44340836	161173	0	None	60	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	471	7	1	4	4.4	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL413707	161173	0	None	60	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	471	7	1	4	4.4	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(02)00690-x
	1809	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
	4	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
	CHEMBL18840	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm020994z
	1809	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
	1809	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
	4	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	CHEMBL18840	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.bmc.2007.05.010
	CHEMBL18840	134	28	None	-2	37	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm049702f
	4106	2456	16	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
	5358812	2456	16	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
	89	2456	16	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
	CHEMBL93240	2456	16	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2020.112149
	145983405	165874	0	None	32	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4277476	165874	0	None	32	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	44266221	206615	0	None	12	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	3	4.5	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9951	206615	0	None	12	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	3	4.5	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	4106	2456	16	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
	5358812	2456	16	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
	89	2456	16	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
	CHEMBL93240	2456	16	None	-4	34	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.1c00497
	25107716	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	8436	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	CHEMBL522691	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	25107716	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	8436	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	CHEMBL522691	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	25107716	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
	8436	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
	CHEMBL522691	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2014.03.005
	25107716	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
	8436	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
	CHEMBL522691	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2012.07.043
	25107716	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	8436	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	CHEMBL522691	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm800615e
	23642275	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	8433	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	CHEMBL2164327	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	9881600	54896	3	None	8	5	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111705
	CHEMBL161765	54896	3	None	8	5	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111705
	44393180	66317	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL185384	66317	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	23642275	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	8433	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	CHEMBL2164327	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	9881600	54896	3	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111690
	CHEMBL161765	54896	3	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.ejmech.2019.111690
	23642275	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
	8433	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
	CHEMBL2164327	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2013.02.038
	9881600	54896	3	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL161765	54896	3	None	8	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
	66803474	155763	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	429	6	2	3	4.2	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4065568	155763	0	None	3	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	429	6	2	3	4.2	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	11681111	120060	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343666	120060	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545815	120060	0	None	7	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	4431	2679	18	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
	73	2679	18	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
	CHEMBL8618	2679	18	None	-20	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2014.08.023
	9881600	54896	3	None	8	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
	CHEMBL161765	54896	3	None	8	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
	24854371	95418	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL259087	95418	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	23642275	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	8433	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	CHEMBL2164327	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	56933434	111592	0	None	6	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	431	7	1	5	3.8	Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289991	111592	0	None	6	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	431	7	1	5	3.8	Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	25107716	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
	8436	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
	CHEMBL522691	2309	35	None	-3	7	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1039/C8MD00313K
	24853955	155640	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL406414	155640	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	5	139	66	None	-5	55	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
	5202	139	66	None	-5	55	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
	CHEMBL39	139	66	None	-5	55	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
	DB08839	139	66	None	-5	55	Rat	9.2	pKi	=	9.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030826m
	44437334	149953	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL395444	149953	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	24854371	95418	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL259087	95418	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	24854037	95417	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	7	1	3	5.2	CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL259086	95417	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	7	1	3	5.2	CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	24854041	95520	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	CHEMBL259549	95520	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	9934709	167250	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL430706	167250	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/s0960-894x(02)00690-x
	9934709	167250	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2010.03.012
	CHEMBL430706	167250	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2010.03.012
	102364516	113031	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1016/j.ejmech.2019.111705
	CHEMBL3321794	113031	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1016/j.ejmech.2019.111705
	10015688	51382	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL158402	51382	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmcl.2003.11.050
	10015688	51382	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmc.2010.01.035
	CHEMBL158402	51382	1	None	12	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	3	3.8	CN(C)CCSc1cccc(C2CCCCC2)n1	10.1016/j.bmc.2010.01.035
	102364516	113031	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321794	113031	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	346	6	0	2	4.0	O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1	10.1021/jm500880c
	66801263	111571	0	None	14	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289970	111571	0	None	14	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	66801210	111619	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	535	8	1	6	6.1	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12	10.1021/jm401895u
	CHEMBL3290017	111619	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	535	8	1	6	6.1	Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12	10.1021/jm401895u
	44340854	9949	0	None	61	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	493	6	2	6	4.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL115262	9949	0	None	61	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	493	6	2	6	4.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(02)00690-x
	3233	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	3247	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	6604889	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	CHEMBL282199	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	DB13988	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2016.06.080
	3233	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	3247	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	6604889	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	CHEMBL282199	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	DB13988	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.12.039
	3233	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	3247	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	6604889	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	CHEMBL282199	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	DB13988	3443	40	None	2	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2015.02.042
	168297777	192292	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5184185	192292	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5222088	192292	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 minsBinding affinity to rat brain 5-HT7 receptor assessed as inhibition constant incubated for 60 mins	ChEMBL	398	8	0	4	3.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(OCCF)c2)CC1	10.1021/acs.jmedchem.2c00633
	145974165	164025	0	None	8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	410	5	0	2	6.0	Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
	CHEMBL4215605	164025	0	None	8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	410	5	0	2	6.0	Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
	118717217	120052	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343667	120052	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545762	120052	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	24829343	158463	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1016/j.ejmech.2019.111705
	CHEMBL409662	158463	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1016/j.ejmech.2019.111705
	24829343	158463	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm200547z
	CHEMBL409662	158463	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm200547z
	24829343	158463	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	CHEMBL409662	158463	0	None	24	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
	145991084	166306	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4285796	166306	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	44340835	10295	0	None	117	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	499	7	1	4	5.0	O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL116292	10295	0	None	117	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	499	7	1	4	5.0	O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	155568606	175524	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4591601	175524	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	532	9	1	6	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	5	139	66	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
	5202	139	66	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
	CHEMBL39	139	66	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
	DB08839	139	66	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.12.045
	5	139	66	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
	5202	139	66	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
	CHEMBL39	139	66	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
	DB08839	139	66	None	-3	55	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm401895u
	66801158	111579	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	464	8	1	6	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289978	111579	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	464	8	1	6	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	56944665	111605	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	CHEMBL3290003	111605	0	None	-1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	56944668	111607	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3290005	111607	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	467	7	1	5	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	25107518	186691	0	None	20	4	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1021/jm800615e
	CHEMBL492871	186691	0	None	20	4	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1021/jm800615e
	9971032	200510	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	282	2	1	1	4.0	Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C	10.1021/jm030826m
	CHEMBL609675	200510	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	282	2	1	1	4.0	Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C	10.1021/jm030826m
	44340850	9794	0	None	22	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	483	7	1	4	4.4	O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL114345	9794	0	None	22	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	483	7	1	4	4.4	O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	155516399	169493	0	None	47	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	368	6	1	5	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	CHEMBL4443201	169493	0	None	47	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	368	6	1	5	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	10069973	52105	0	None	4	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	407	9	0	6	4.4	COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1021/jm020994z
	CHEMBL159022	52105	0	None	4	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	407	9	0	6	4.4	COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1021/jm020994z
	155552188	173482	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	2	3	4.6	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4544153	173482	0	None	7	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	2	3	4.6	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1	10.1016/j.bmcl.2019.126703
	1809	134	28	None	-7	37	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
	4	134	28	None	-7	37	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
	CHEMBL18840	134	28	None	-7	37	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm030030n
	4106	2456	16	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	5358812	2456	16	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	89	2456	16	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	CHEMBL93240	2456	16	None	-4	34	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm401895u
	66801234	111596	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	469	7	1	5	4.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289995	111596	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	469	7	1	5	4.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	66801271	111600	0	None	5	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	423	7	1	6	3.6	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289999	111600	0	None	5	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	423	7	1	6	3.6	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
	66801139	111611	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
	CHEMBL3290009	111611	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
	23643870	92418	0	None	35	4	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243955	92418	0	None	35	4	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	44437328	90537	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239656	90537	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	1809	134	28	None	-7	37	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
	4	134	28	None	-7	37	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
	CHEMBL18840	134	28	None	-7	37	Human	9.0	pKi	=	9.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/acs.jmedchem.7b01898
	107	141	116	None	-1	31	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
	1833	141	116	None	-1	31	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
	CHEMBL8165	141	116	None	-1	31	Rat	9.0	pKi	=	9.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030826m
	25107520	187000	0	None	70	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	CHEMBL494709	187000	0	None	70	3	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1021/jm800615e
	141745651	174764	0	None	1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	380	4	1	4	4.3	Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
	CHEMBL4574299	174764	0	None	1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	380	4	1	4	4.3	Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
	118713589	113862	0	None	10	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	6	0	5	4.0	Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331258	113862	0	None	10	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	6	0	5	4.0	Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	44393134	64503	0	None	39	2	Human	9.0	pKi	=	9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182071	64503	0	None	39	2	Human	9.0	pKi	=	9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	4184551	192050	7	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	352	5	1	4	2.7	CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1	10.1016/j.bmcl.2021.128275
	CHEMBL5218527	192050	7	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	352	5	1	4	2.7	CC1CCN(CCC2CCCN2S(=O)(=O)c2cccc(O)c2)CC1	10.1016/j.bmcl.2021.128275
	3233	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	3247	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	6604889	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	CHEMBL282199	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	DB13988	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2010.11.078
	7059581	166481	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1016/s0960-894x(00)00166-9
	CHEMBL428892	166481	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1016/s0960-894x(00)00166-9
	3233	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	3247	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	6604889	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	CHEMBL282199	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	DB13988	3443	40	None	2	12	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00438-9
	11725453	98610	0	None	1	6	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/s0960-894x(02)00438-9
	CHEMBL28056	98610	0	None	1	6	Human	9.0	pKi	=	9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/s0960-894x(02)00438-9
	3233	3443	40	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	3247	3443	40	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	6604889	3443	40	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	CHEMBL282199	3443	40	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	DB13988	3443	40	None	-2	12	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm049743b
	7059581	166481	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm049743b
	CHEMBL428892	166481	3	None	-1	2	Rat	9.0	pKi	=	9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm049743b
	127025243	137205	0	None	60	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759205	137205	0	None	60	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1	10.1016/j.ejmech.2015.11.040
	145985692	164881	0	None	-3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239091	164881	0	None	-3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626161	165036	0	None	-1	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4242858	165036	0	None	-1	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626129	165079	0	None	3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243848	165079	0	None	3	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	156021386	177506	0	None	7	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4647808	177506	0	None	7	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	4106	2456	16	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
	5358812	2456	16	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
	89	2456	16	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
	CHEMBL93240	2456	16	None	-4	34	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/acs.jmedchem.7b00839
	66803595	159169	0	None	1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	431	6	3	4	3.6	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4104622	159169	0	None	1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	431	6	3	4	3.6	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	155531753	171070	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4465959	171070	0	None	-1	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	548	11	1	7	4.5	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	19605739	169434	12	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	204	3	3	2	1.4	NCCc1c[nH]c2ccc(C(=O)O)cc12	10.1016/j.ejmech.2019.111705
	CHEMBL4442472	169434	12	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	204	3	3	2	1.4	NCCc1c[nH]c2ccc(C(=O)O)cc12	10.1016/j.ejmech.2019.111705
	2389	3267	114	None	-9	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	5073	3267	114	None	-9	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	96	3267	114	None	-9	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	CHEMBL85	3267	114	None	-9	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	DB00734	3267	114	None	-9	68	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	16006607	95215	4	None	10	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	219	2	2	4	2.1	CC(C)Oc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	CHEMBL258075	95215	4	None	10	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	219	2	2	4	2.1	CC(C)Oc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	7059581	166481	3	None	1	2	Human	9.0	pKi	=	9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm030841r
	CHEMBL428892	166481	3	None	1	2	Human	9.0	pKi	=	9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2	10.1021/jm030841r
	11661471	158969	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	408	7	1	2	5.9	CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL410226	158969	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	408	7	1	2	5.9	CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	10346043	46841	0	None	-1	3	Human	9.0	pKi	=	9.0	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)	ChEMBL	503	5	2	5	3.4	COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL154274	46841	0	None	-1	3	Human	9.0	pKi	=	9.0	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)	ChEMBL	503	5	2	5	3.4	COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	10379532	98805	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmcl.2010.03.012
	CHEMBL281923	98805	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmcl.2010.03.012
	10062885	98806	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm060959i
	CHEMBL281924	98806	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm060959i
	78108787	191360	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	363	6	1	3	4.0	Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.2c00633
	CHEMBL5201016	191360	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	363	6	1	3	4.0	Cc1ccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.2c00633
	10379532	98805	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
	CHEMBL281923	98805	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
	10062885	98806	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
	CHEMBL281924	98806	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm030030n
	10062885	98806	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmc.2020.115578
	CHEMBL281924	98806	0	None	1	6	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1016/j.bmc.2020.115578
	10379532	98805	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL281923	98805	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	10062885	98806	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL281924	98806	0	None	-1	6	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	291	1	0	2	3.7	CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	24854044	96837	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm200547z
	CHEMBL269083	96837	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm200547z
	56944664	111568	0	None	23	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	428	8	1	6	3.0	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289968	111568	0	None	23	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	428	8	1	6	3.0	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
	56944764	111591	0	None	3	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	417	6	1	5	3.4	Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289990	111591	0	None	3	4	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	417	6	1	5	3.4	Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	23643663	92398	0	None	13	4	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243744	92398	0	None	13	4	Rat	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	145981875	165957	0	None	7	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4278933	165957	0	None	7	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	145992877	166332	0	None	11	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	413	6	1	2	5.7	Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4286174	166332	0	None	11	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	413	6	1	2	5.7	Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	3044582	191805	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2	10.1016/j.ejmech.2022.114218
	CHEMBL5208064	191805	2	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)CC(N1CCN(C)CC1)c1ccccc1S2	10.1016/j.ejmech.2022.114218
	11524003	158968	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL410225	158968	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmcl.2009.06.038
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2011.09.044
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2012.07.043
	118717211	120054	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343663	120054	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545801	120054	0	None	33	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	11524003	158968	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL410225	158968	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	392	7	1	2	5.4	CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	66801346	111594	0	None	1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	485	7	1	5	4.8	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289993	111594	0	None	1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	485	7	1	5	4.8	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	24854181	95972	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL262068	95972	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111705
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/s0960-894x(02)00690-x
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2013.02.038
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/acs.jmedchem.7b01898
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2014.08.023
	3233	3443	40	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	3247	3443	40	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	6604889	3443	40	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	CHEMBL282199	3443	40	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	DB13988	3443	40	None	-2	12	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm0108505
	24825775	1490	10	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1490	10	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1490	10	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030030n
	15803947	52060	1	None	13	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	161	3	0	2	2.1	CN(C)CCSC(C)(C)C	10.1016/j.bmcl.2003.11.050
	CHEMBL158973	52060	1	None	13	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	161	3	0	2	2.1	CN(C)CCSC(C)(C)C	10.1016/j.bmcl.2003.11.050
	24825775	1490	10	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3929	1490	10	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	CHEMBL4205349	1490	10	None	346	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.1c00110
	3233	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	3247	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	6604889	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	DB13988	3443	40	None	2	12	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.bmc.2016.09.019
	118717223	120058	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343671	120058	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545813	120058	0	None	7	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	56944859	111603	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	CHEMBL3290001	111603	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	453	6	1	5	4.3	O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12	10.1021/jm401895u
	56944384	111616	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	521	8	1	6	5.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3290014	111616	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	521	8	1	6	5.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	66801565	111622	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	474	7	1	7	4.1	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3290020	111622	0	None	7	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	474	7	1	7	4.1	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	2389	3267	114	None	-9	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	5073	3267	114	None	-9	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	96	3267	114	None	-9	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	CHEMBL85	3267	114	None	-9	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	DB00734	3267	114	None	-9	68	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030030n
	60196080	81381	2	None	12	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	CHEMBL2164330	81381	2	None	12	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	2737389	186993	23	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL494675	186993	23	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	11637931	120059	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343665	120059	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545814	120059	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	5	139	66	None	-3	55	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
	5202	139	66	None	-3	55	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
	CHEMBL39	139	66	None	-3	55	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
	DB08839	139	66	None	-3	55	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2014.04.034
	56944666	111608	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3290006	111608	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	481	8	1	5	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	2737389	186993	23	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1039/C8MD00313K
	CHEMBL494675	186993	23	None	53	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis	ChEMBL	238	2	1	2	2.8	c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1039/C8MD00313K
	162643494	181057	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4775997	181057	0	None	3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
	24854111	95302	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL258496	95302	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	425	8	1	3	5.3	CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	66801229	111552	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	6	1	6	3.6	O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289952	111552	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	6	1	6	3.6	O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	66800939	111553	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	7	1	6	3.9	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289953	111553	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	466	7	1	6	3.9	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	56944667	111593	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	445	8	1	5	4.2	Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289992	111593	0	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	445	8	1	5	4.2	Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1021/jm401895u
	24854183	95444	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	413	7	1	3	4.6	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL259216	95444	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	413	7	1	3	4.6	CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL5094234	213787	0	None	2	8	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	213787	0	None	2	8	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	134155116	150424	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3958215	150424	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL5091373	213781	0	None	1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	213781	0	None	1	9	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	134155116	150424	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3958215	150424	0	None	12	7	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	309	3	0	2	3.6	O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	132525570	163082	0	None	6	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	300	5	0	5	2.8	CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
	CHEMBL4204059	163082	0	None	6	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	300	5	0	5	2.8	CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
	56944565	111544	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	444	8	1	6	3.5	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289944	111544	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	444	8	1	6	3.5	Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	56944383	111614	0	None	-3	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3290012	111614	0	None	-3	12	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	44437330	151645	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396844	151645	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	44266268	206052	0	None	10	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	394	5	0	3	3.8	O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9616	206052	0	None	10	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	394	5	0	3	3.8	O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	162652285	179685	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4750664	179685	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
	162654074	179987	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
	CHEMBL4754138	179987	0	None	-3	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
	11500509	120057	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120057	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120057	0	None	3	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	66801107	111541	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	430	7	1	6	3.1	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289709	111541	0	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	430	7	1	6	3.1	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	4106	2456	16	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
	5358812	2456	16	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
	89	2456	16	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
	CHEMBL93240	2456	16	None	-4	34	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmcl.2018.04.059
	118713592	113866	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331261	113866	0	None	3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
	11187960	65883	0	None	6	2	Rat	8.8	pKi	=	8.8	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	CHEMBL184535	65883	0	None	6	2	Rat	8.8	pKi	=	8.8	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	44437329	151056	0	None	-8	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396349	151056	0	None	-8	2	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	1809	134	28	None	-2	37	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
	4	134	28	None	-2	37	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
	CHEMBL18840	134	28	None	-2	37	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1021/jm400766k
	118717220	120056	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343669	120056	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545811	120056	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	56944564	111554	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	480	8	1	6	4.3	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289954	111554	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	480	8	1	6	4.3	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	24854185	157154	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	439	8	1	3	5.6	CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL408191	157154	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	439	8	1	3	5.6	CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	44340834	109723	0	None	169	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	494	6	1	6	4.0	O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL323778	109723	0	None	169	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	494	6	1	6	4.0	O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	155567938	175450	0	None	20	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	386	8	2	5	2.8	NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
	CHEMBL4590226	175450	0	None	20	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	386	8	2	5	2.8	NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
	10834268	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm0104264
	CHEMBL428494	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm0104264
	10834268	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm980519u
	CHEMBL428494	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm980519u
	168288462	191099	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5196950	191099	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
	60195993	81385	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2ccccc2N2CCNCC2)cc1C	10.1021/jm3003679
	CHEMBL2164334	81385	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2ccccc2N2CCNCC2)cc1C	10.1021/jm3003679
	3233	3443	40	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	3247	3443	40	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	6604889	3443	40	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	CHEMBL282199	3443	40	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	DB13988	3443	40	None	2	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1016/j.ejmech.2019.111690
	56944383	111614	0	None	-3	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3290012	111614	0	None	-3	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	24854105	157378	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
	CHEMBL408450	157378	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm070279v
	155542678	172581	0	None	281	2	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	487	7	1	4	4.9	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL4521657	172581	0	None	281	2	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	487	7	1	4	4.9	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2019.111705
	10028436	3463	3	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
	3237	3463	3	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
	CHEMBL95104	3463	3	None	1	12	Rat	8.7	pKi	=	8.7	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2004.11.013
	44396223	123280	0	None	281	2	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	486	7	0	4	5.0	O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1021/jm0498102
	CHEMBL362354	123280	0	None	281	2	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	486	7	0	4	5.0	O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1021/jm0498102
	10573876	10348	0	None	199	7	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm991151j
	CHEMBL116448	10348	0	None	199	7	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm991151j
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm991151j
	44368731	119173	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm030841r
	CHEMBL347286	119173	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	414	5	0	3	3.7	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1	10.1021/jm030841r
	11047374	18706	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL12846	18706	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	10834268	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL428494	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	10834268	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm030841r
	CHEMBL428494	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1021/jm030841r
	10433930	50801	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL157910	50801	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	10028436	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	3237	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	CHEMBL95104	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	46203758	124015	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640556	124015	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
	44393072	168699	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	8	2	6	3.7	C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL441312	168699	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	8	2	6	3.7	C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	2389	3267	114	None	-9	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	5073	3267	114	None	-9	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	96	3267	114	None	-9	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	CHEMBL85	3267	114	None	-9	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	DB00734	3267	114	None	-9	68	Human	8.0	pKi	=	8	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	10171	57	15	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
	272	57	15	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
	CHEMBL274384	57	15	None	-5	6	Rat	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/s0960-894x(00)00166-9
	10499156	113579	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
	CHEMBL332701	113579	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
	10249573	205849	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL94984	205849	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	44368705	45594	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
	CHEMBL153156	45594	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
	10596321	205721	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	CHEMBL94261	205721	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	44460708	203886	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	CHEMBL81607	203886	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	10249573	205849	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
	CHEMBL94984	205849	0	None	1	11	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
	44461065	203823	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	389	4	0	3	4.4	Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81022	203823	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	389	4	0	3	4.4	Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	44460708	203886	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81607	203886	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	331	3	0	3	3.9	Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	10249573	205849	0	None	-1	11	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm049743b
	CHEMBL94984	205849	0	None	-1	11	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm049743b
	5	139	66	None	-5	55	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	5202	139	66	None	-5	55	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	CHEMBL39	139	66	None	-5	55	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	DB08839	139	66	None	-5	55	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	9894665	103323	1	None	-30	8	Human	8.0	pKi	=	8	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	585	10	2	8	3.3	CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1	10.1021/jm9905918
	CHEMBL309106	103323	1	None	-30	8	Human	8.0	pKi	=	8	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	585	10	2	8	3.3	CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1	10.1021/jm9905918
	46203758	124015	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640556	124015	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	339	5	1	4	3.6	COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1	nan
	CHEMBL5074880	212558	0	None	1	9	Human	8.0	pKi	=	8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	127028472	137630	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769534	137630	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	470	8	2	6	2.2	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2016.02.024
	127038281	136550	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	494	10	0	6	4.0	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1016/j.bmc.2015.11.041
	CHEMBL3747240	136550	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	494	10	0	6	4.0	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1016/j.bmc.2015.11.041
	127041259	136561	0	None	4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	420	8	0	6	2.7	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747459	136561	0	None	4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	420	8	0	6	2.7	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
	145985505	165062	0	None	-3	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243579	165062	0	None	-3	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	134145903	148334	0	None	5	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3941529	148334	0	None	5	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
	71456781	81002	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	3.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159471	81002	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	3.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	71458651	81008	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	439	8	1	5	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159477	81008	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	439	8	1	5	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1	10.1016/j.ejmech.2012.07.043
	71456784	81023	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159492	81023	0	None	1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	242	467	117	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	34	467	117	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	60795	467	117	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	CHEMBL1112	467	117	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	DB01238	467	117	None	-15	52	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2022.114193
	118731352	117673	0	None	2	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	510	9	1	4	4.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409036	117673	0	None	2	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	510	9	1	4	4.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	118731362	117682	0	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	564	8	0	4	5.6	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409045	117682	0	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	564	8	0	4	5.6	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	145947590	167133	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4170657	167133	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4302436	167133	0	None	8	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	516	7	2	6	2.4	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	145947976	167142	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4168743	167142	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4302539	167142	0	None	41	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	438	7	2	6	1.6	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	56944952	156813	0	None	-2	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4077937	156813	0	None	-2	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	24854103	95695	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
	CHEMBL260551	95695	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
	127052458	140196	0	None	3	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818056	140196	0	None	3	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	90644074	111567	0	None	151	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	414	7	1	6	2.6	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289967	111567	0	None	151	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	414	7	1	6	2.6	Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1	10.1021/jm401895u
	56943695	111617	0	None	-4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	505	7	1	6	5.2	Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3290015	111617	0	None	-4	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	505	7	1	6	5.2	Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	10171	57	15	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
	272	57	15	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
	CHEMBL274384	57	15	None	-11	6	Human	8.0	pKi	=	8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030841r
	90656682	110476	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	6	2	4	3.0	Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262411	110476	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	6	2	4	3.0	Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	11525867	95766	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
	CHEMBL260870	95766	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
	44266289	97698	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	404	4	1	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL273872	97698	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	404	4	1	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	127052458	140196	0	None	3	7	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818056	140196	0	None	3	7	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	242	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	34	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	60795	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	CHEMBL1112	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	DB01238	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113243
	242	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	34	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	60795	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	CHEMBL1112	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	DB01238	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2020.115943
	242	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	34	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	60795	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	CHEMBL1112	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	DB01238	467	117	None	-15	52	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	10714877	113860	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	6	3.2	COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331256	113860	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	6	3.2	COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	11825614	102124	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	403	6	1	3	4.5	Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL304167	102124	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	403	6	1	3	4.5	Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	46204726	124034	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL3640574	124034	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	46204726	124034	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL3640574	124034	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	327	3	1	2	4.4	FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	134155476	150681	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3960056	150681	0	None	7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.9	C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1016/j.ejmech.2016.05.005
	2726	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	621	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	83	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	CHEMBL71	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	DB00477	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	76336186	105908	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121435	105908	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139448	105908	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	11667458	65653	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	350	6	1	4	3.1	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
	CHEMBL1836788	65653	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	350	6	1	4	3.1	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
	11407754	97716	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL273982	97716	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	49850870	56080	0	None	-794	9	Human	7.0	pKi	=	7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631535	56080	0	None	-794	9	Human	7.0	pKi	=	7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
	242	467	117	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	34	467	117	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	60795	467	117	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	CHEMBL1112	467	117	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	DB01238	467	117	None	-15	52	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
	135398737	942	89	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	38	942	89	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	722	942	89	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	CHEMBL42	942	89	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	DB00363	942	89	None	-13	92	Human	7.0	pKi	=	7	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	11407754	97716	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	CHEMBL273982	97716	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	429	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	44374234	55252	0	None	12	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1ccnc(-c2ccccc2)c1	10.1016/j.bmcl.2003.11.050
	CHEMBL162071	55252	0	None	12	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1ccnc(-c2ccccc2)c1	10.1016/j.bmcl.2003.11.050
	10737314	96809	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL268921	96809	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	10737314	96809	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	CHEMBL268921	96809	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	11166042	165805	0	None	-2	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1021/jm049743b
	CHEMBL427518	165805	0	None	-2	3	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1021/jm049743b
	135	2486	38	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	1796	2486	38	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	4184	2486	38	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	CHEMBL6437	2486	38	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	DB06148	2486	38	None	-50	58	Rat	7.0	pKi	=	7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	CHEMBL5071978	212491	0	None	-1	6	Human	7.0	pKi	=	7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	127041874	136510	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	450	8	0	4	4.5	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
	CHEMBL3746713	136510	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	450	8	0	4	4.5	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
	145975905	163265	0	None	5	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	376	4	1	4	2.4	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4206366	163265	0	None	5	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	376	4	1	4	2.4	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	11414582	180746	0	None	-16	4	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4762886	180746	0	None	-16	4	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	2470	3583	46	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	3300	3583	46	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	5265	3583	46	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	99	3583	46	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	CHEMBL267930	3583	46	None	-1258	60	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.ejmech.2019.111705
	44439409	90771	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	5	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL240025	90771	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	5	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21	10.1016/j.bmcl.2007.01.093
	44439404	91339	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	334	3	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241103	91339	0	None	15	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	334	3	0	3	4.0	CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	21509921	103966	0	None	-9	24	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104091	103966	0	None	-9	24	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	11808247	17876	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL126667	17876	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819366	17876	0	None	-1	9	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	9888211	21201	9	None	-125	10	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
	CHEMBL131495	21201	9	None	-125	10	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
	10317515	99285	2	None	-19	4	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand	ChEMBL	378	3	0	4	1.8	O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1016/s0960-894x(03)00160-4
	CHEMBL285066	99285	2	None	-19	4	Rat	7.0	pKi	=	7	Binding	Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand	ChEMBL	378	3	0	4	1.8	O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1016/s0960-894x(03)00160-4
	46204086	124022	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
	CHEMBL3640562	124022	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
	11327643	119064	0	None	1	2	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL346191	119064	0	None	1	2	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
	240	929	39	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	2769	929	39	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	44279790	929	39	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	660	929	39	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	CHEMBL1729	929	39	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	CHEMBL560739	929	39	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	DB00604	929	39	None	-199	25	Human	6.0	pKi	=	6	Binding	Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	135398745	2858	108	None	-95	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	47	2858	108	None	-95	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	CHEMBL715	2858	108	None	-95	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	DB00334	2858	108	None	-95	66	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	2337	3193	72	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	50	3193	72	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	5002	3193	72	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	CHEMBL716	3193	72	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	DB01224	3193	72	None	-28	63	Human	6.0	pKi	=	6	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
	11327643	119064	0	None	-1	2	Rat	6.0	pKi	=	6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	CHEMBL346191	119064	0	None	-1	2	Rat	6.0	pKi	=	6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	421	6	0	4	4.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	9827938	11651	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	CHEMBL1181680	11651	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	CHEMBL188486	11651	0	None	-39	12	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	46204086	124022	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
	CHEMBL3640562	124022	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2cccc(C)c2)cc1OC1CNC1	nan
	10125797	161250	8	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	CHEMBL41436	161250	8	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	CHEMBL541621	161250	8	None	-407	4	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	153287574	174665	0	None	-13	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4572167	174665	0	None	-13	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	146709966	175196	0	None	-338	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4583909	175196	0	None	-338	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	153287539	175490	0	None	-3	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4591008	175490	0	None	-3	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	2543	3638	66	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	5358	3638	66	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	54	3638	66	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	CHEMBL128	3638	66	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	DB00669	3638	66	None	-93	32	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1016/j.ejmech.2019.111705
	44439403	91338	0	None	-5	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	394	5	0	5	4.0	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL241102	91338	0	None	-5	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	394	5	0	5	4.0	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CC3)CC2	10.1016/j.bmcl.2007.01.093
	76524414	140325	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819434	140325	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819713	140325	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	9913554	100510	0	None	-1258	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL29433	100510	0	None	-1258	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
	46204732	124038	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	CHEMBL3640578	124038	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	46204734	124041	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
	CHEMBL3640580	124041	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
	46205044	124046	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
	CHEMBL3640585	124046	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
	10668422	97700	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL273890	97700	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	10643153	98058	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL276255	98058	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	46204732	124038	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	CHEMBL3640578	124038	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	250	3	1	3	2.6	N#Cc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	46204734	124041	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
	CHEMBL3640580	124041	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1cc(C#N)c(OC2CNC2)cc1-c1ccccc1	nan
	46205044	124046	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
	CHEMBL3640585	124046	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	297	5	1	3	3.8	Cc1ccccc1-c1ccc(OC(C)C)c(OC2CNC2)c1	nan
	3034396	101155	33	None	-165	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL299031	101155	33	None	-165	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	11462900	56700	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	372	4	1	3	4.7	FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644270	56700	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	372	4	1	3	4.7	FC(F)(F)Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	53316608	56706	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	344	3	1	2	5.1	CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644276	56706	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	344	3	1	2	5.1	CC(C)(C)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	53316609	56707	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644277	56707	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
	11449570	56711	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	304	3	2	3	3.6	Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644281	56711	0	None	-	1	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	304	3	2	3	3.6	Oc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	3251	3997	50	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
	5684	3997	50	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
	80	3997	50	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
	CHEMBL31354	3997	50	None	-33113	12	Human	5.0	pKi	=	5	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1009956
	44368373	119040	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	CHEMBL345971	119040	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	10668422	97700	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1021/jm030841r
	CHEMBL273890	97700	0	None	-	1	Human	4.0	pKi	=	4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	395	6	1	3	4.3	O=C1Nc2cccc3c2C1(CCCCN1CCN(C2CCCCC2)CC1)CCC3	10.1021/jm030841r
	76524414	140325	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819434	140325	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819713	140325	0	None	-77	8	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	426	6	1	4	5.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	118724647	120081	0	None	-5	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361004	120081	0	None	-5	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546104	120081	0	None	-5	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	381	6	0	7	1.7	Cn1c(=O)c2c(ncn2CCCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	11603887	102104	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
	CHEMBL2431046	102104	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
	CHEMBL3040877	102104	0	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	407	10	1	4	3.5	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1-c1ccccc1	10.1021/jm400766k
	90654670	109589	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	427	9	1	6	2.4	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235742	109589	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	427	9	1	6	2.4	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	136180321	117199	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401483	117199	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	11291892	132977	1	None	-24	4	Rat	7.0	pKi	=	7	Binding	In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesIn vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranes	ChEMBL	378	3	0	4	1.8	O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm048999e
	CHEMBL370758	132977	1	None	-24	4	Rat	7.0	pKi	=	7	Binding	In vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranesIn vitro inhibition of [3H]5-CT binding to 5-hydroxytryptamine 7 receptor in rat hypothalamus membranes	ChEMBL	378	3	0	4	1.8	O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm048999e
	10994400	203401	0	None	-109	4	Human	7.0	pKi	=	7	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	439	5	1	2	4.4	OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
	CHEMBL77855	203401	0	None	-109	4	Human	7.0	pKi	=	7	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	439	5	1	2	4.4	OC(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
	2880253	162145	9	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	7	1	2	5.4	CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
	CHEMBL4170813	162145	9	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	7	1	2	5.4	CCC1(C)CC(CCNCc2ccccc2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
	71457409	82535	0	None	-3981	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	461	5	0	4	4.9	CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1	10.1021/jm300943r
	CHEMBL2181168	82535	0	None	-3981	6	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	461	5	0	4	4.9	CCCN1CCC(COc2nc3c(I)cccc3c3ncccc23)CC1	10.1021/jm300943r
	134147951	149260	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	5	0	3	3.4	COc1ccccc1-c1cc(CN(C)C)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3948597	149260	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	5	0	3	3.4	COc1ccccc1-c1cc(CN(C)C)ccc1OC	10.1016/j.ejmech.2016.07.029
	10737314	96809	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	CHEMBL268921	96809	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	361	4	1	3	3.4	O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	CHEMBL5076882	212685	0	None	-26	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cccc(Cl)c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	CHEMBL5083505	213084	0	None	-2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00497
	1534	102553	51	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	102553	51	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	102553	51	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	10314060	168024	0	None	-72	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	322	4	1	4	2.9	COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
	CHEMBL435949	168024	0	None	-72	7	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	322	4	1	4	2.9	COc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
	122442272	137807	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	137807	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	137807	0	None	-40	15	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	18137015	163777	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4212558	163777	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2Cl)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	23369457	188914	2	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	322	4	1	4	2.2	O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL514058	188914	2	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	322	4	1	4	2.2	O=c1[nH]c2ccccc2n1CCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	10754042	99326	0	None	2	4	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O	10.1021/jm9911433
	CHEMBL285352	99326	0	None	2	4	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3O	10.1021/jm9911433
	1534	102553	51	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	102553	51	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	102553	51	None	1	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	134135372	143852	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	295	4	0	2	4.6	COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3906019	143852	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	295	4	0	2	4.6	COc1ccccc1-c1cccc(CN2CCC(C)CC2)c1	10.1016/j.ejmech.2016.07.029
	168291659	191430	0	None	-14	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	356	8	3	8	1.4	Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5202120	191430	0	None	-14	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	356	8	3	8	1.4	Nc1nc(N)nc(NCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	135414318	206040	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	298	0	1	5	3.1	CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1	10.1021/jm030030n
	CHEMBL96055	206040	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	298	0	1	5	3.1	CN1CCN(C2=Nc3ccccc3Nc3sccc32)CC1	10.1021/jm030030n
	145978146	163353	0	None	4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4207310	163353	0	None	4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	156013326	176910	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	4	1	4	3.8	COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4639400	176910	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	4	1	4	3.8	COc1cc2c3c(c1OCC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	124247485	163506	7	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	163506	7	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	124247485	163506	7	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	163506	7	None	-1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	2950739	162401	10	None	-4	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	4	4.6	COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4174845	162401	10	None	-4	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	4	4.6	COc1ccc(CNCCC(c2ccco2)c2ccccc2OC)cc1	10.1016/j.ejmech.2018.04.010
	57403525	69796	0	None	-691	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940402	69796	0	None	-691	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	21533446	69797	0	None	-281	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940403	69797	0	None	-281	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	122483264	137551	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763534	137551	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765840	137551	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	71726944	101918	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
	CHEMBL3039669	101918	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
	CHEMBL3215698	101918	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	342	2	0	4	3.3	CN1CCN(Cc2cccc3c(=O)c4ccc(Cl)cc4oc23)CC1	10.1016/j.bmcl.2013.05.062
	44388796	127525	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	415	5	0	4	4.8	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL366516	127525	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	415	5	0	4	4.8	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C(F)(F)F)c2)CC1	10.1016/j.bmcl.2005.05.059
	11131952	49074	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	353	8	1	5	3.4	O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL156385	49074	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	353	8	1	5	3.4	O=C(CCCCCN1CCN(c2ccccn2)CC1)c1ccccc1O	10.1021/jm020994z
	156016142	177164	0	None	-5	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	506	8	0	6	5.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4642594	177164	0	None	-5	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	506	8	0	6	5.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	155554326	174366	0	None	-13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	457	9	0	6	3.2	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4565558	174366	0	None	-13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	457	9	0	6	3.2	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	10638372	173804	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	306	4	0	2	3.0	O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL455210	173804	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	306	4	0	2	3.0	O=C1Cc2ccccc2N1CCCN1CCc2ccccc2C1	10.1021/jm8014553
	145946265	166942	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4203310	166942	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4299892	166942	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	122483264	137551	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763534	137551	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765840	137551	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	334	6	0	3	5.1	O=C(CCCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	155536533	171610	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	444	7	1	5	4.8	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12	10.1016/j.ejmech.2019.111690
	CHEMBL4473636	171610	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	444	7	1	5	4.8	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2cc(-c3ccccc3)sc12	10.1016/j.ejmech.2019.111690
	155547693	172989	0	None	-51	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
	CHEMBL4532712	172989	0	None	-51	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1cccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
	90654683	109602	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	452	8	1	4	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235755	109602	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	452	8	1	4	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	44437860	90791	0	None	-48	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	411	6	0	4	3.2	CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C	10.1016/j.bmc.2007.07.029
	CHEMBL240110	90791	0	None	-48	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	411	6	0	4	3.2	CC1C(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1C	10.1016/j.bmc.2007.07.029
	53325849	56699	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644269	56699	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	54758201	65647	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	451	6	1	3	5.7	O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	CHEMBL1836782	65647	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	451	6	1	3	5.7	O=C1Nc2c(Cl)cc(Cl)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	60165413	74995	0	None	-31	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	378	7	0	4	5.5	O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037531	74995	0	None	-31	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	378	7	0	4	5.5	O=C(CCCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	168288780	190842	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	3.9	O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5193103	190842	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	3.9	O=c1n(CCCCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	122483226	137565	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763504	137565	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765871	137565	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	122483226	137565	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763504	137565	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765871	137565	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	377	5	0	4	3.8	CC(=O)N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	90654703	109587	0	None	26	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	399	7	1	6	1.6	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235740	109587	0	None	26	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	399	7	1	6	1.6	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	134147935	149145	0	None	18	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3947670	149145	0	None	18	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	154956306	179074	0	None	-31	7	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	435	6	0	6	4.5	Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O	10.1016/j.ejmech.2020.112709
	CHEMBL4743324	179074	0	None	-31	7	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	435	6	0	6	4.5	Cn1ccc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2c1=O	10.1016/j.ejmech.2020.112709
	90656690	110483	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	7	2	4	2.8	OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262418	110483	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	7	2	4	2.8	OCc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	118728522	117201	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	390	8	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401485	117201	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	390	8	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
	164616670	184020	0	None	-53	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4849077	184020	0	None	-53	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	11726532	96565	0	None	-141	4	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	0	5	3.5	COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	CHEMBL26677	96565	0	None	-141	4	Rat	7.0	pKi	=	7.0	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	0	5	3.5	COc1cccc(C(=O)CCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	44460669	203881	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	283	4	0	3	2.9	C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81576	203881	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	283	4	0	3	2.9	C=Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	44460724	203898	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	339	4	0	4	4.0	CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81684	203898	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	339	4	0	4	4.0	CN1CCCN(CCn2ccc3ccc(-c4ccsc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
	168289915	190948	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	553	11	4	8	4.9	Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5194614	190948	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	553	11	4	8	4.9	Nc1nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	60195992	81384	2	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	CHEMBL2164333	81384	2	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	10938620	202359	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	416	7	1	3	5.2	COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	CHEMBL70048	202359	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	416	7	1	3	5.2	COc1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	155538236	171795	0	None	-40	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	496	7	1	5	5.2	O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4476164	171795	0	None	-40	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	496	7	1	5	5.2	O=c1c(-c2ccccc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	155515920	176100	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4442332	176100	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4598348	176100	0	None	-109	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.ejmech.2019.06.001
	46203754	124012	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
	CHEMBL3640553	124012	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
	10024070	66838	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	402	8	0	4	3.5	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
	CHEMBL187764	66838	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	402	8	0	4	3.5	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
	46203754	124012	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
	CHEMBL3640553	124012	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cccc(C)c2C)cc1OC1CNC1	nan
	71458652	81009	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	5	3.0	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159478	81009	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	5	3.0	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2012.07.043
	118731353	117596	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	524	10	1	4	4.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3407516	117596	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	524	10	1	4	4.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	145980458	166153	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	476	6	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4282860	166153	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	476	6	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
	155526720	170634	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4459410	170634	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cccs2)c1	10.1016/j.bmcl.2019.126703
	155552707	173466	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	1	3	5.5	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4543789	173466	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	421	6	1	3	5.5	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccoc2)c1	10.1016/j.bmcl.2019.126703
	2726	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	621	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	83	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	CHEMBL71	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	DB00477	904	64	None	-13	73	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2013.02.038
	54758204	65649	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL1836784	65649	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	395	7	1	3	4.4	CCC1(CCCCN2CCN(c3cccc(F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	11393666	192374	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5201983	192374	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5222597	192374	0	None	-28	19	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	42618267	182231	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL479105	182231	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2009.02.008
	11683077	65656	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	414	6	1	2	5.7	O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
	CHEMBL1836791	65656	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	414	6	1	2	5.7	O=C1Nc2ccccc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
	71061887	92672	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442996	92672	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71061887	92672	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442996	92672	0	None	66	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	44266284	96882	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	377	5	0	3	5.1	Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL269400	96882	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	377	5	0	3	5.1	Cc1ccccc1OC1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	22273749	206436	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	4	0	3	4.7	COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9840	206436	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	4	0	3	4.7	COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1	10.1016/s0960-894x(03)00077-5
	135398737	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	38	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	722	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	CHEMBL42	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	DB00363	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2020.115578
	11191128	84772	0	None	2	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/acs.jmedchem.5b00982
	CHEMBL225512	84772	0	None	2	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/acs.jmedchem.5b00982
	11191128	84772	0	None	2	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL225512	84772	0	None	2	5	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	2	4	4.3	O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	134137732	147224	0	None	11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3932551	147224	0	None	11	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	179	396	107	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	2159	396	107	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	963	396	107	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	CHEMBL243712	396	107	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	DB06288	396	107	None	-9	51	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayDisplacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1016/j.bmcl.2021.128275
	90656711	110466	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262393	110466	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	90656711	110466	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262393	110466	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	371	4	2	3	4.4	Oc1ccc2[nH]cc(CCN3CCN(c4cccc5ccccc45)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	118713683	113876	0	None	-9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	6	4.0	COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331386	113876	0	None	-9	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	6	4.0	COc1ccccc1N1CCN(CCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	44266245	166653	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	398	5	0	3	4.3	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL429202	166653	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	398	5	0	3	4.3	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(Cl)cc2)CC1	10.1016/s0960-894x(03)00077-5
	136180320	117198	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401482	117198	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	4	4.1	O=c1[nH]c(CCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	164622487	185530	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	339	4	0	4	2.8	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4871850	185530	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	339	4	0	4	2.8	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	2470	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL5071978	212491	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	145976686	163359	0	None	24	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207365	163359	0	None	24	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	56944861	156520	0	None	-42	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4074195	156520	0	None	-42	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	2470	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	2470	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	3300	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	5265	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	99	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	CHEMBL267930	3583	46	None	-1258	60	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 minsDisplacement of [3H]5-HT from human 5HT7 receptor expressed in African green monkey COS7 cell membrane incubated for 30 mins	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/j.bmc.2016.06.011
	11207101	75576	1	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
	CHEMBL2051975	75576	1	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
	9818448	126945	0	None	-17	3	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	318	4	1	2	4.5	COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1	10.1021/jm049743b
	CHEMBL366081	126945	0	None	-17	3	Rat	6.0	pKi	=	6.0	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	318	4	1	2	4.5	COc1ccc2[nH]cc(C3=CCN(Cc4ccccc4)CC3)c2c1	10.1021/jm049743b
	1353	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	3559	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	86	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	CHEMBL54	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	DB00502	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	198914	146158	8	None	79	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	264	1	3	2	3.1	Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL392401	146158	8	None	79	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	264	1	3	2	3.1	Oc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	71460455	80940	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159314	80940	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1	10.1016/j.ejmech.2012.07.043
	71462156	80945	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	445	6	1	4	5.1	O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159319	80945	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	445	6	1	4	5.1	O=C(NC1CCN(CCSc2cccc(Cl)c2Cl)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	90654673	109592	0	None	-54	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	494	10	1	5	3.9	CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235745	109592	0	None	-54	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	494	10	1	5	3.9	CSc1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	11154555	786	57	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	5037	786	57	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	7671	786	57	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	CHEMBL2028019	786	57	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	CHEMBL3085826	786	57	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	DB06016	786	57	None	-117	12	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2019.111736
	118736376	118430	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	531	7	0	9	3.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423340	118430	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	531	7	0	9	3.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2015.04.046
	127052487	140256	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3818805	140256	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
	90656681	110478	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	327	6	0	3	3.5	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262413	110478	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	327	6	0	3	3.5	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2014.04.034
	155561995	175139	0	None	-36	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	532	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4582567	175139	0	None	-36	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	532	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccc(F)cc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	155522218	170060	0	None	-51	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	492	7	1	5	5.3	O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
	CHEMBL4451231	170060	0	None	-51	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	492	7	1	5	5.3	O=c1c(-c2ccccc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
	145983018	164954	0	None	-125	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	CHEMBL4240910	164954	0	None	-125	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cccc5ncccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	46204083	124018	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640559	124018	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
	46204083	124018	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640559	124018	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	357	4	1	3	4.4	COc1ccc(-c2c(Cl)cccc2C(F)(F)F)cc1OC1CNC1	nan
	118724648	115952	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	515	7	0	10	1.5	Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361005	115952	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	515	7	0	10	1.5	Cn1c(=O)c2c(nc(N3CCOCC3)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	127052487	140256	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3818805	140256	0	None	-6	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	422	6	2	3	5.1	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2c[nH]c3ccccc23)CC1	10.1016/j.bmc.2016.06.011
	49756	202599	9	None	-14	8	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030826m
	CHEMBL7143	202599	9	None	-14	8	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030826m
	1353	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	3559	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	86	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	CHEMBL54	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	DB00502	1872	85	None	-263	86	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-5-carboxyamidotryptamine from human 5HT7 receptor by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2016.06.011
	134154108	152076	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	309	4	0	2	4.9	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3972166	152076	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	309	4	0	2	4.9	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	90654701	109585	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	426	7	1	4	2.8	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235738	109585	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	426	7	1	4	2.8	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	57398619	71207	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1949962	71207	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1963099	71207	0	None	7	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	136180318	117196	0	None	-14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401480	117196	0	None	-14	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3ccc(Cl)cc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	46204089	124025	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
	CHEMBL3640565	124025	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
	46204089	124025	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
	CHEMBL3640565	124025	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2cc(C)ccc2C)cc1OC1CNC1	nan
	44286416	140874	0	None	-11	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	448	8	0	6	4.3	O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL38409	140874	0	None	-11	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	448	8	0	6	4.3	O=C1c2ccccc2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	156014787	176961	0	None	3	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	428	6	1	5	3.6	COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4640281	176961	0	None	3	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	428	6	1	5	3.6	COc1cc2c3c(c1OCC1CC1)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	15443	117294	91	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL340211	117294	91	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
	15443	117294	91	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL340211	117294	91	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	162673483	183180	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4796251	183180	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803945	183180	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	396	8	2	5	2.3	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	71458622	80932	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	376	7	1	5	3.7	CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159306	80932	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	376	7	1	5	3.7	CSc1ccccc1OCCN1CCC(NC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
	71727068	90822	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401934	90822	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401938	90822	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cc(CN4CCN(c5ccccc5OC)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	155510928	175885	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4435010	175885	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4596543	175885	0	None	-575	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	368	4	2	6	2.9	COc1ccc2c(c1)c(-c1cnc(N)[nH]1)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	13069623	120084	0	None	-50	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360994	120084	0	None	-50	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546108	120084	0	None	-50	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	396	6	0	8	1.0	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	44456400	12710	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL1188501	12710	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL2436555	12710	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL536539	12710	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	10317139	66726	0	None	-758	2	Rat	4.9	pKi	=	4.9	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	371	4	0	5	2.3	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL187270	66726	0	None	-758	2	Rat	4.9	pKi	=	4.9	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	371	4	0	5	2.3	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)CCC3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
	145973438	163960	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4214853	163960	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
	145971588	163990	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4215182	163990	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
	155539483	172283	0	None	-162	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	504	7	2	3	5.4	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
	CHEMBL4515160	172283	0	None	-162	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	504	7	2	3	5.4	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
	44456400	12710	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL1188501	12710	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL2436555	12710	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL536539	12710	0	None	-4	10	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	122181336	121351	0	None	-8	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	432	6	1	4	3.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590088	121351	0	None	-8	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	432	6	1	4	3.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	118731347	117668	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	4	3.4	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409031	117668	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	4	3.4	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	44455426	154598	0	None	-12	13	Human	6.9	pKi	=	6.9	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL402143	154598	0	None	-12	13	Human	6.9	pKi	=	6.9	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	72198191	89376	0	None	-144	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	5	2	3	4.5	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
	CHEMBL2377445	89376	0	None	-144	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	5	2	3	4.5	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
	46205373	124054	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
	CHEMBL3640593	124054	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
	46205373	124054	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
	CHEMBL3640593	124054	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2cccc(C(F)(F)F)c2)cc1C1CCNC1	nan
	122181339	121354	0	None	-22	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	500	6	1	4	4.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590091	121354	0	None	-22	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	500	6	1	4	4.4	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	156013203	176898	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.7	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4639203	176898	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.7	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2020.115459
	156021656	177603	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4649308	177603	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2)C1	10.1016/j.bmc.2019.115262
	162647097	179129	0	None	-125	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4744007	179129	0	None	-125	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
	156020908	177447	0	None	-2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	0	6	5.4	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4646868	177447	0	None	-2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	0	6	5.4	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	54758298	65662	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL1836857	65662	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.08.023
	11207101	75576	1	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
	CHEMBL2051975	75576	1	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	236	4	0	4	1.5	COc1ccc2c(c1)N(CCN(C)C)CCO2	10.1021/jm049743b
	44263956	202733	1	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	232	4	0	3	2.3	COc1ccc2c(c1)c(CCN(C)C)cn2C	10.1021/jm049743b
	CHEMBL7220	202733	1	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	232	4	0	3	2.3	COc1ccc2c(c1)c(CCN(C)C)cn2C	10.1021/jm049743b
	90654700	109584	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235737	109584	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	71454899	80733	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	5	4.3	CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158026	80733	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	10	1	5	4.3	CCOc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2SC)CC1	10.1016/j.ejmech.2012.07.043
	155526651	170598	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	464	8	0	4	5.7	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4458938	170598	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	464	8	0	4	5.7	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc3cccnc23)CC1	10.1016/j.bmcl.2019.06.029
	155540823	171963	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	456	7	0	5	3.6	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4483779	171963	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	456	7	0	5	3.6	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	2726	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	621	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	83	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	CHEMBL71	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	DB00477	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	11409589	84692	0	None	-1	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	CHEMBL224883	84692	0	None	-1	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	127029649	137631	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	462	6	2	5	2.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3769536	137631	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	462	6	2	5	2.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	126720403	162048	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	4	1	5	3.2	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
	CHEMBL4169236	162048	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	4	1	5	3.2	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
	155542321	172544	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
	CHEMBL4520796	172544	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2019.06.022
	155542321	172544	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2022.114645
	CHEMBL4520796	172544	0	None	-1096	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	356	5	1	7	2.2	Cc1ccc(C(C)C)c(OCc2nc(N)nc(N3CCN(C)CC3)n2)c1	10.1016/j.ejmech.2022.114645
	90654685	109604	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	522	5	1	4	4.4	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235757	109604	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	522	5	1	4	4.4	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.ejmech.2014.03.005
	162670959	183162	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4791316	183162	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803791	183162	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	90654694	109578	0	None	-27	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	402	9	1	5	1.9	COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235731	109578	0	None	-27	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	402	9	1	5	1.9	COc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	10947658	28475	0	None	-10	17	Human	7.9	pKi	=	7.9	Binding	Binding affinities against 5-hydroxytryptamine 7 receptorBinding affinities against 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL137781	28475	0	None	-10	17	Human	7.9	pKi	=	7.9	Binding	Binding affinities against 5-hydroxytryptamine 7 receptorBinding affinities against 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	46214153	110193	0	None	3	5	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
	CHEMBL3260334	110193	0	None	3	5	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
	44374299	119019	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmcl.2003.11.050
	CHEMBL345803	119019	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmcl.2003.11.050
	11603514	71131	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926760	71131	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962492	71131	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	127026450	137219	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759281	137219	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
	145985233	164960	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4241050	164960	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	145984737	165016	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4242392	165016	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	145985527	165145	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4245622	165145	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	145985823	165360	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4250475	165360	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	6	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1016/j.ejmech.2018.01.002
	134153716	151940	0	None	9	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3971125	151940	0	None	9	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	71453252	80935	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159309	80935	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	71453282	81022	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159491	81022	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	71574210	85842	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312934	85842	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	118731351	117672	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409035	117672	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	118731365	117685	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	592	10	0	4	6.4	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409048	117685	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	592	10	0	4	6.4	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	145947977	167143	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4162279	167143	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4302540	167143	0	None	48	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	433	6	2	6	1.5	CC1(c2ccccc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	23642275	479	28	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
	8433	479	28	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
	CHEMBL2164327	479	28	None	60	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	10.1016/j.bmc.2019.115262
	71453252	80935	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1039/C5MD00166H
	CHEMBL2159309	80935	0	None	15	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	476	8	1	5	4.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1039/C5MD00166H
	142601335	185829	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	185829	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	66803497	157953	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4091193	157953	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	145964944	163518	0	None	-14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	391	4	0	4	5.0	Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
	CHEMBL4209430	163518	0	None	-14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	391	4	0	4	5.0	Clc1ccc(CCN2CCN(c3nsc4ccccc34)CC2)cc1Cl	10.1016/j.bmcl.2017.11.007
	10862787	102550	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1016/j.bmc.2019.06.028
	CHEMBL307101	102550	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1016/j.bmc.2019.06.028
	90656696	110496	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	367	9	1	4	4.2	CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262430	110496	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	367	9	1	4	4.2	CN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	44374299	119019	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmc.2010.01.035
	CHEMBL345803	119019	2	None	17	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1nc(-c2ccccc2)cs1	10.1016/j.bmc.2010.01.035
	127051844	140303	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819427	140303	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	145988193	166515	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4289605	166515	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2cc(F)ccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	90656672	110490	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	451	8	1	5	3.8	O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262425	110490	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	451	8	1	5	3.8	O=S(=O)(c1ccccc1)N(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	155565215	175027	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	433	6	1	7	3.5	Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
	CHEMBL4580230	175027	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	433	6	1	7	3.5	Nn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
	10862787	102550	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1021/jm0104264
	CHEMBL307101	102550	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	423	6	1	3	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2Cl)CC1)CCC3	10.1021/jm0104264
	11826723	202532	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	464	6	1	2	5.9	O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL71057	202532	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	464	6	1	2	5.9	O=C1Nc2ccc(Br)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	142601335	185829	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	185829	0	None	44	7	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127051844	140303	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819427	140303	0	None	1	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	72734860	103467	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092753	103467	0	None	-6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	44456395	95214	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	225	1	2	4	2.0	COc1c(Cl)ccc2c1C(C)NC(N)=N2	10.1016/j.bmcl.2007.10.080
	CHEMBL258073	95214	0	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	225	1	2	4	2.0	COc1c(Cl)ccc2c1C(C)NC(N)=N2	10.1016/j.bmcl.2007.10.080
	11302161	66927	0	None	-8	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
	CHEMBL188176	66927	0	None	-8	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	337	7	0	2	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
	44319240	106414	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	374	6	1	2	4.8	O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL314672	106414	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	374	6	1	2	4.8	O=C1Nc2cccc3c2C1(CCCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	135398737	942	89	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	38	942	89	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	722	942	89	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	CHEMBL42	942	89	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	DB00363	942	89	None	-7	92	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00166-9
	6540428	184271	1	None	-7	4	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL3989558	184271	1	None	-7	4	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL485253	184271	1	None	-7	4	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/s0960-894x(00)00166-9
	10571274	98987	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	CHEMBL283065	98987	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	135398737	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	38	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	722	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	CHEMBL42	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	DB00363	942	89	None	-13	92	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030841r
	6540428	184271	1	None	-19	4	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
	CHEMBL3989558	184271	1	None	-19	4	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
	CHEMBL485253	184271	1	None	-19	4	Human	7.9	pKi	=	7.9	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/jm030841r
	11151958	66622	0	None	-9	3	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
	CHEMBL186758	66622	0	None	-9	3	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccc(OC)cc2)C1	10.1021/jm0498102
	71062123	92671	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442995	92671	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71062123	92671	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442995	92671	0	None	6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	76284453	104514	0	None	67	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	476	10	1	5	4.0	Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1	10.1016/j.bmc.2014.01.016
	CHEMBL3113595	104514	0	None	67	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	476	10	1	5	4.0	Cc1ccccc1-c1ccccc1N1CCN(CCOCCC(=O)NCc2ccc(F)nc2)CC1	10.1016/j.bmc.2014.01.016
	90656713	110467	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	385	4	2	3	4.7	Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262394	110467	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	385	4	2	3	4.7	Cc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
	162662399	181337	0	None	-12	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4779739	181337	0	None	-12	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	399	7	1	5	3.1	Cc1cccc(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)c1	10.1016/j.ejmech.2020.112149
	11948707	165603	0	None	-158	13	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1021/acs.jmedchem.2c00633
	CHEMBL426317	165603	0	None	-158	13	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1021/acs.jmedchem.2c00633
	21830793	91389	5	None	-85	46	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	CHEMBL2413154	91389	5	None	-85	46	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	118728524	117203	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401487	117203	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2015.02.042
	145990586	166279	0	None	-9	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	CHEMBL4285281	166279	0	None	-9	11	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	66801425	156632	0	None	-39	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	441	8	2	3	4.5	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4075673	156632	0	None	-39	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	441	8	2	3	4.5	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	66801354	111578	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	450	7	1	6	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	CHEMBL3289977	111578	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	450	7	1	6	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1	10.1021/jm401895u
	44437329	151056	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396349	151056	0	None	-8	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	692	18	0	8	7.1	COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	46205700	123861	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3639394	123861	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46204088	124024	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	CHEMBL3640564	124024	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	46205697	124059	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3640598	124059	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46206344	124074	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
	CHEMBL3640612	124074	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
	46205700	123861	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3639394	123861	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46204088	124024	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	CHEMBL3640564	124024	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	255	4	1	3	2.7	COc1ccc(-c2ccccc2)cc1OC1CNC1	nan
	46205697	124059	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3640598	124059	2	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	223	2	1	1	3.4	c1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46206344	124074	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
	CHEMBL3640612	124074	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	2	1	1	4.7	Cc1ccc(-c2ccc(Cl)cc2C2CCNC2)cc1C	nan
	162662361	180880	0	None	-20	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4764557	180880	0	None	-20	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	465	8	1	6	4.0	COc1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc2c1	10.1016/j.ejmech.2020.112149
	2726	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	621	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	83	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	CHEMBL71	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	DB00477	904	64	None	-13	73	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2013.12.024
	15443	117294	91	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL340211	117294	91	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2021.113243
	15443	117294	91	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL340211	117294	91	None	-17	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	44374206	52262	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	248	5	1	4	2.1	CN(C)CCSc1n[nH]c(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL159223	52262	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	248	5	1	4	2.1	CN(C)CCSc1n[nH]c(-c2ccccc2)n1	10.1016/j.bmcl.2003.11.050
	60364	105900	9	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
	CHEMBL3121413	105900	9	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
	CHEMBL3139439	105900	9	None	-19	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	264	4	0	2	3.7	CN(C)CCc1cn(-c2ccccc2)c2ccccc12	10.1016/j.ejmech.2014.01.055
	21557475	174307	0	None	-6	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	442	8	0	5	4.2	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4564093	174307	0	None	-6	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	442	8	0	5	4.2	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	71602639	89237	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376449	89237	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	23661735	90543	0	None	-467	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	423	3	0	4	3.7	O=C1CCCC(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239681	90543	0	None	-467	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	423	3	0	4	3.7	O=C1CCCC(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
	145946271	166945	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4162548	166945	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4299919	166945	0	None	-3	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	495	7	2	6	2.5	N#Cc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	145965840	163453	0	None	2	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	425	5	1	4	3.8	O=C1Nc2ccccc2C12CCN(CCN1CCC(Oc3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4208468	163453	0	None	2	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	425	5	1	4	3.8	O=C1Nc2ccccc2C12CCN(CCN1CCC(Oc3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	71449642	81007	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	7	1	5	2.8	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159476	81007	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	7	1	5	2.8	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	90654842	112134	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233670	112134	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302936	112134	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1cccc(N2CCN(CCCCCN3C(=O)N(Cc4ccccc4)C(=O)C3(C)C)CC2)c1	10.1016/j.ejmech.2014.01.065
	118736374	118428	0	None	-13	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	559	8	0	9	4.0	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423338	118428	0	None	-13	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	559	8	0	9	4.0	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	11328878	136394	0	None	2	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	469	9	1	4	5.2	COc1cc(Cl)ccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL374261	136394	0	None	2	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	469	9	1	4	5.2	COc1cc(Cl)ccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	136118614	92618	0	None	-13	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2442276	92618	0	None	-13	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	2843443	117416	18	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	380	2	0	2	5.3	Brc1ccc2c(c1)c1c3n2CCN(Cc2ccccc2)C3CCC1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403336	117416	18	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	380	2	0	2	5.3	Brc1ccc2c(c1)c1c3n2CCN(Cc2ccccc2)C3CCC1	10.1016/j.bmcl.2015.03.049
	56850924	71163	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926758	71163	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962806	71163	0	None	-22	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	90654850	112136	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233674	112136	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302943	112136	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	502	9	0	4	4.6	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	156015194	176969	0	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	377	4	2	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4640332	176969	0	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	377	4	2	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	10313351	10151	23	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1cccc2c1C[C@H](N)CC2	10.1021/jm030826m
	CHEMBL1161324	10151	23	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1cccc2c1C[C@H](N)CC2	10.1021/jm030826m
	42618253	180715	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	5	0	5	3.6	O=c1n(CCN2CCN(c3ccccc3)CC2)c2ccccc2n1-c1ccccc1	10.1016/j.bmcl.2009.02.008
	CHEMBL476248	180715	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	5	0	5	3.6	O=c1n(CCN2CCN(c3ccccc3)CC2)c2ccccc2n1-c1ccccc1	10.1016/j.bmcl.2009.02.008
	135367869	164171	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4217548	164171	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	9419	35678	29	None	-616	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1016/j.bmcl.2020.127493
	CHEMBL1442422	35678	29	None	-616	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1016/j.bmcl.2020.127493
	126720440	162464	0	None	-2041	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	339	4	1	5	2.6	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
	CHEMBL4175829	162464	0	None	-2041	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	339	4	1	5	2.6	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(F)c1	10.1016/j.ejmech.2017.12.053
	71574300	85845	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312937	85845	0	None	-5	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
	155554325	175937	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4548353	175937	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4597000	175937	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	118736367	118421	0	None	-10	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	479	7	1	10	1.7	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423331	118421	0	None	-10	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	479	7	1	10	1.7	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
	15599151	173357	0	None	-1621	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of 5HT7R (unknown origin)Inhibition of 5HT7R (unknown origin)	ChEMBL	379	4	3	8	1.3	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL4541086	173357	0	None	-1621	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of 5HT7R (unknown origin)Inhibition of 5HT7R (unknown origin)	ChEMBL	379	4	3	8	1.3	O[C@@H]1[C@@H](CCl)O[C@@H](n2cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)ncnc32)[C@@H]1O	10.1021/acs.jmedchem.8b01662
	135367869	164171	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4217548	164171	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	164614828	184677	0	None	-186	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4858771	184677	0	None	-186	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	44268087	19979	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	CHEMBL13049	19979	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	44460641	105357	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	271	3	0	3	2.6	Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL312720	105357	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	271	3	0	3	2.6	Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	53370045	165869	7	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	376	6	2	6	0.5	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C)C2=O)CC1	10.1039/C8MD00168E
	CHEMBL4277406	165869	7	None	3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	376	6	2	6	0.5	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C)C2=O)CC1	10.1039/C8MD00168E
	164614734	184804	0	None	-41	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	443	8	0	6	2.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4860754	184804	0	None	-41	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	443	8	0	6	2.8	COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	155546595	172961	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	586	10	1	6	5.8	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4531761	172961	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	586	10	1	6	5.8	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	44424662	85339	0	None	-8	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	488	9	0	9	2.5	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229366	85339	0	None	-8	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	488	9	0	9	2.5	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	11421024	84256	0	None	30	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL222603	84256	0	None	30	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	1346	83	108	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
	280	83	108	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
	9899402	83	108	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
	CHEMBL9666	83	108	None	-147	9	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm030826m
	49850772	56090	0	None	-794	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631545	56090	0	None	-794	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	10619437	16380	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	CHEMBL12389	16380	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	10619437	16380	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL12389	16380	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	44368683	45280	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	CHEMBL152873	45280	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	134156222	153805	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
	CHEMBL3986927	153805	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
	CHEMBL5073337	212511	0	None	-30	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	CHEMBL5093017	213616	0	None	-35	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc(F)c(Cl)c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	162657622	180545	0	None	-48	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4760655	180545	0	None	-48	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
	277	1269	55	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	2913	1269	55	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	765	1269	55	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL516	1269	55	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	DB00434	1269	55	None	-70	46	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/j.ejmech.2019.111705
	11248705	89850	0	None	-50	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238519	89850	0	None	-50	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	11178830	147582	0	None	-79	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL393539	147582	0	None	-79	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	122483276	137572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763677	137572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765878	137572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	60167451	74983	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL2037520	74983	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	145971527	162555	0	None	-7	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	337	7	1	2	5.6	Cc1ccc(C(C)NCCC(c2ccc(F)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4177293	162555	0	None	-7	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	337	7	1	2	5.6	Cc1ccc(C(C)NCCC(c2ccc(F)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
	57393878	68075	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917353	68075	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	164610188	184462	0	None	-194	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4855393	184462	0	None	-194	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	1574	81	52	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
	218	81	52	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
	CHEMBL266591	81	52	None	-13	21	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	10.1021/jm030030n
	11191906	11647	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	CHEMBL1181665	11647	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	CHEMBL187928	11647	0	None	-25	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	71602639	89237	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376449	89237	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	155519891	169814	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	CHEMBL4447975	169814	0	None	-5	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	153287568	170408	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	CHEMBL4456195	170408	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	1524	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	197	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	3822	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	88	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	CHEMBL51	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	DB12465	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.ejmech.2019.111705
	52952420	62247	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	377	5	1	5	4.0	N#Cc1ccc(N2CCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782808	62247	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	377	5	1	5	4.0	N#Cc1ccc(N2CCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	17374371	117410	9	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	447	5	1	5	4.7	O=S(=O)(Nc1ccn(Cc2cccc3ccccc23)n1)c1ccc(Br)s1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403330	117410	9	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	447	5	1	5	4.7	O=S(=O)(Nc1ccn(Cc2cccc3ccccc23)n1)c1ccc(Br)s1	10.1016/j.bmcl.2015.03.049
	57399868	71197	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949978	71197	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963032	71197	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	134140472	145476	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	0	2	3.4	COc1ccccc1-c1cccc(CN(C)C)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3918663	145476	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	0	2	3.4	COc1ccccc1-c1cccc(CN(C)C)c1	10.1016/j.ejmech.2016.07.029
	49756	202599	9	None	-5	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030030n
	CHEMBL7143	202599	9	None	-5	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm030030n
	46204731	124037	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640577	124037	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	46204731	124037	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640577	124037	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	318	3	1	3	3.6	N#Cc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	134156222	153805	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
	CHEMBL3986927	153805	0	None	-1	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	334	5	1	3	3.2	O=C1Cc2cc(C(=O)CCCN3CCc4ccccc4C3)ccc2N1	10.1016/j.bmc.2016.09.019
	122483276	137572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763677	137572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765878	137572	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	439	8	0	4	5.8	O=C(CCCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	60167451	74983	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037520	74983	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	60167451	74983	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL2037520	74983	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	468	7	1	6	5.3	O=C(CCCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	22425072	117424	6	None	-1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	457	5	0	4	6.5	Cc1ccc(S(=O)(=O)c2cnc3ccc(F)cc3c2SCc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403343	117424	6	None	-1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	457	5	0	4	6.5	Cc1ccc(S(=O)(=O)c2cnc3ccc(F)cc3c2SCc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2015.03.049
	122442272	137807	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	137807	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	137807	0	None	-40	15	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT7 receptor by radioligand binding assayBinding affinity to human 5HT7 receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	137646281	157252	0	None	-295	17	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4083252	157252	0	None	-295	17	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
	46233350	198606	0	None	7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	286	5	0	3	4.0	Cc1cccc(C)c1-c1cccc(SCCN(C)C)n1	10.1016/j.bmc.2010.01.035
	CHEMBL597357	198606	0	None	7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	286	5	0	3	4.0	Cc1cccc(C)c1-c1cccc(SCCN(C)C)n1	10.1016/j.bmc.2010.01.035
	4723431	170847	13	None	-14	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	316	6	2	2	4.8	c1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4462814	170847	13	None	-14	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	316	6	2	2	4.8	c1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	122483231	137546	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765208	137546	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765835	137546	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	122483231	137546	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765208	137546	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765835	137546	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	336	8	0	3	5.3	CCCCN(C)CCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	11443608	143186	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	CHEMBL390062	143186	0	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)C(NC(=O)CCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	46205695	124057	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
	CHEMBL3640596	124057	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
	46206025	124072	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
	CHEMBL3640610	124072	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
	46205695	124057	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
	CHEMBL3640596	124057	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccc(-c2ccccc2)cc1C1CCNC1	nan
	46206025	124072	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
	CHEMBL3640610	124072	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	2	1	1	4.7	Clc1cccc(-c2ccc(Cl)cc2C2CCNC2)c1	nan
	44393021	64704	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cncc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182356	64704	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cncc(NCCc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	154926540	189720	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	439	10	1	4	4.6	CCC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
	CHEMBL5176380	189720	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	439	10	1	4	4.6	CCC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
	54764323	68081	0	None	85	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917359	68081	0	None	85	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	127040908	136536	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747071	136536	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	71449641	80988	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	9	1	4	4.6	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159458	80988	0	None	3	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	9	1	4	4.6	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	60196073	81389	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	CHEMBL2164339	81389	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	10571274	98987	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL283065	98987	0	None	42	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	371	3	0	3	5.1	COc1cccc(OC)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	44408816	76210	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	8	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206305	76210	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	8	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	54758392	65659	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	398	6	1	2	5.5	O=C1Nc2cc(F)ccc2C1CCCCN1CC=C(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	CHEMBL1836794	65659	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	398	6	1	2	5.5	O=C1Nc2cc(F)ccc2C1CCCCN1CC=C(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	66801000	111557	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	472	7	1	7	4.0	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3289957	111557	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	472	7	1	7	4.0	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	56944473	111623	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	8	1	7	4.5	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3290021	111623	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	8	1	7	4.5	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	9839050	111873	0	None	-26	9	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
	CHEMBL329566	111873	0	None	-26	9	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
	162664534	181510	0	None	14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	418	9	0	6	4.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4781863	181510	0	None	14	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	418	9	0	6	4.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	90656691	110486	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	7	1	4	3.1	O=Cc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262421	110486	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	7	1	4	3.1	O=Cc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	135458394	97229	5	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	0	2	3	2.9	CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
	CHEMBL271298	97229	5	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	0	2	3	2.9	CNC1=Nc2ccc(Cl)c(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
	11173572	129372	0	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
	CHEMBL367584	129372	0	None	-1	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
	10706626	98663	0	None	1	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm030030n
	CHEMBL281048	98663	0	None	1	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm030030n
	10706626	98663	0	None	-1	6	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm9911433
	CHEMBL281048	98663	0	None	-1	6	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3N	10.1021/jm9911433
	11173572	129372	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmc.2010.01.035
	CHEMBL367584	129372	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	281	2	0	2	3.8	Cc1cccc(C)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmc.2010.01.035
	46203760	124016	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	CHEMBL3640557	124016	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	46203760	124016	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	CHEMBL3640557	124016	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	10730269	96643	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O	10.1021/jm9911433
	CHEMBL26751	96643	0	None	1	4	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	263	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@H]3O	10.1021/jm9911433
	135895192	171635	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	418	6	1	5	4.3	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4473885	171635	0	None	85	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	418	6	1	5	4.3	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	122181341	121356	0	None	-42	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCC(c4ccccc4)CC3)C2=O)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590093	121356	0	None	-42	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCC(c4ccccc4)CC3)C2=O)CC1	10.1016/j.bmc.2015.04.026
	162672061	183171	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4793191	183171	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803857	183171	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	7	1	4	4.5	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	44424654	85313	0	None	-5	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	460	7	0	9	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229123	85313	0	None	-5	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	460	7	0	9	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	9867475	17814	0	None	-426	10	Human	5.9	pKi	=	5.9	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	432	7	0	5	4.2	CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	CHEMBL126340	17814	0	None	-426	10	Human	5.9	pKi	=	5.9	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	432	7	0	5	4.2	CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	2870750	117414	7	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	442	4	1	5	6.0	Nc1c(S(=O)(=O)c2ccccc2)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12	10.1016/j.bmcl.2015.03.049
	CHEMBL3403334	117414	7	None	-2	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	442	4	1	5	6.0	Nc1c(S(=O)(=O)c2ccccc2)sc2nc(-c3ccccc3)cc(-c3ccccc3)c12	10.1016/j.bmcl.2015.03.049
	122483238	137563	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763567	137563	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765853	137563	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	24768524	92756	0	None	-4	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL244577	92756	0	None	-4	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	13069627	120088	0	None	-26	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361001	120088	0	None	-26	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546113	120088	0	None	-26	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	444	7	0	8	2.1	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	134136246	141994	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
	CHEMBL3890841	141994	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
	162663078	181402	0	None	-46	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
	CHEMBL4780470	181402	0	None	-46	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
	134130594	141700	0	None	-7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884728	141700	0	None	-7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
	16763549	117425	9	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	342	5	1	5	2.8	COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c1N	10.1016/j.bmcl.2015.03.049
	CHEMBL3403344	117425	9	None	-4	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	342	5	1	5	2.8	COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(Cl)cc2)c1N	10.1016/j.bmcl.2015.03.049
	90654697	109581	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235734	109581	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
	122483238	137563	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763567	137563	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765853	137563	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	6	0	4	4.3	O=C(CCCCCN1CCOCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	57397410	68065	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917343	68065	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
	134136246	141994	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
	CHEMBL3890841	141994	0	None	-1	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	275	3	0	1	4.1	C1=C(CCN2CCc3ccccc3C2)Cc2ccccc21	10.1016/j.bmc.2016.09.019
	156010584	176495	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633042	176495	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	56649648	67498	0	None	-398	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910139	67498	0	None	-398	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	10780842	97442	0	None	-1	5	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL27247	97442	0	None	-1	5	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	134131151	141692	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	9	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884634	141692	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	9	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	155538877	172214	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	382	7	1	5	3.1	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	CHEMBL4513482	172214	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	382	7	1	5	3.1	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	1524	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	197	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	3822	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	88	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	CHEMBL51	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	DB12465	2141	89	None	-512	52	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1021/jm030030n
	164618028	184751	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4859988	184751	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	42618270	90753	0	None	-22	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.8	O=C1C2=C(CCCC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239897	90753	0	None	-22	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.8	O=C1C2=C(CCCC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	164618028	184751	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4859988	184751	0	None	-9	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	352	7	1	4	3.2	CC(=O)Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	162671033	183163	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4793296	183163	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4803797	183163	0	None	-4	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	145985958	165047	0	None	-112	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243036	165047	0	None	-112	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	18137017	162964	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4202769	162964	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	164624246	185351	0	None	-158	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4869411	185351	0	None	-158	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	10042333	162910	1	None	-831	3	Human	5.9	pKi	=	5.9	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	331	5	1	2	4.0	OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
	CHEMBL420010	162910	1	None	-831	3	Human	5.9	pKi	=	5.9	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	331	5	1	2	4.0	OC(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
	118731355	117675	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	10	0	5	3.7	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409038	117675	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	10	0	5	3.7	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1	10.1016/j.ejmech.2014.12.041
	90654844	112114	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233671	112114	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302598	112114	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.01.065
	71727067	90821	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401937	90821	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL3217036	90821	0	None	-8	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	414	5	0	5	4.3	COc1ccc2c(=O)c3cc(CN4CCN(Cc5ccccc5)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	155524491	170379	0	None	-169	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccccc2Cl)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4455658	170379	0	None	-169	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccccc2Cl)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	71458648	80989	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	4	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159459	80989	0	None	-1	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	8	1	4	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	118736364	118418	0	None	-676	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	451	6	1	10	1.0	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423328	118418	0	None	-676	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	451	6	1	10	1.0	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	90656706	112100	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262436	112100	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3302236	112100	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	443	11	1	4	5.8	Oc1cccc(N(CCCCCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	155516118	169461	2	None	-549	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	351	6	3	4	4.0	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ncc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4442855	169461	2	None	-549	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	351	6	3	4	4.0	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ncc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	134131015	141761	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1ccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
	CHEMBL3885282	141761	0	None	-15	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1ccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
	155569396	175554	0	None	10	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	279	2	1	2	4.1	CCn1cncc1-c1c[nH]c2ccc(C(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4592256	175554	0	None	10	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	279	2	1	2	4.1	CCn1cncc1-c1c[nH]c2ccc(C(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
	134144304	153944	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3952251	153944	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3990525	153944	0	None	-2	9	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	168281650	190598	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5189417	190598	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	155533850	171316	0	None	-45	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccc(Cl)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4469633	171316	0	None	-45	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	530	7	1	5	5.8	O=c1c(-c2ccc(Cl)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	44460701	203544	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	302	4	0	5	2.2	CN1CCCN(CCn2ccc3ccc([N+](=O)[O-])cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL78977	203544	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	302	4	0	5	2.2	CN1CCCN(CCn2ccc3ccc([N+](=O)[O-])cc32)CC1	10.1016/s0960-894x(02)00438-9
	54758294	65652	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL1836787	65652	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	44424667	85282	0	None	-60	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	398	5	1	8	-0.1	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL228938	85282	0	None	-60	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	398	5	1	8	-0.1	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	122483254	137555	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764307	137555	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765844	137555	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	10472143	118759	0	None	-31	17	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL343755	118759	0	None	-31	17	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	53324535	56697	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	323	3	1	3	3.9	Clc1ccc(-c2nn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644267	56697	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	323	3	1	3	3.9	Clc1ccc(-c2nn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	242	467	117	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	34	467	117	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	60795	467	117	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	CHEMBL1112	467	117	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	DB01238	467	117	None	-15	52	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm030030n
	44461070	203915	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	4	0	3	3.8	CC(C)N1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81784	203915	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	4	0	3	3.8	CC(C)N1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	137642134	157784	0	None	10	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4089427	157784	0	None	10	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	127028473	137732	0	None	22	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770639	137732	0	None	22	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	451	6	2	6	1.6	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	127026451	137225	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759342	137225	0	None	12	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	8	1	4	4.8	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	127026752	137257	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2cccc(F)c2)C1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759577	137257	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2cccc(F)c2)C1	10.1016/j.ejmech.2015.11.040
	127026133	137283	0	None	6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	5.4	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759819	137283	0	None	6	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	8	1	4	5.4	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	145983128	165261	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4248597	165261	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	134155645	150529	0	None	7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3958956	150529	0	None	7	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	71458650	81005	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159474	81005	0	None	1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	155566925	175281	0	None	56	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	293	1	1	2	3.5	Cn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4585956	175281	0	None	56	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	293	1	1	2	3.5	Cn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
	66801295	156587	0	None	-8	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4075144	156587	0	None	-8	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	447	7	2	3	4.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	164621610	185599	0	None	2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4872800	185599	0	None	2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	118706282	120006	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310111	120006	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3545465	120006	0	None	-17	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	66801246	111621	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	7	3.6	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3290019	111621	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	7	3.6	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	118713681	113874	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	379	8	0	5	4.0	O=c1oc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331384	113874	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	379	8	0	5	4.0	O=c1oc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	44266203	97942	0	None	19	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	389	4	0	5	3.2	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL275475	97942	0	None	19	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	389	4	0	5	3.2	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	164621610	185599	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4872800	185599	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2ccc(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	134157769	153513	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	2	6	4.7	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCO)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3984541	153513	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	2	6	4.7	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCO)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	162676611	182882	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	501	9	1	6	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4799274	182882	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	501	9	1	6	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
	164614709	184616	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4857665	184616	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	69729	169095	60	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	180	4	0	1	3.2	CCCCC(=O)c1ccc(F)cc1	10.1021/jm030030n
	CHEMBL443757	169095	60	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	180	4	0	1	3.2	CCCCC(=O)c1ccc(F)cc1	10.1021/jm030030n
	45272891	194231	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	459	9	3	5	2.4	COc1ccccc1N1CCN(C(=N)NCCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL559260	194231	0	None	2	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	459	9	3	5	2.4	COc1ccccc1N1CCN(C(=N)NCCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1016/j.bmcl.2009.06.038
	44460642	204023	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	281	3	0	3	2.3	C#Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL82708	204023	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	281	3	0	3	2.3	C#Cc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	24873261	182602	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4795756	182602	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	56944860	158449	0	None	-61	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	CHEMBL4096479	158449	0	None	-61	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	8	2	3	5.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	155520553	175925	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4449590	175925	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4596888	175925	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	599482	201286	9	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
	CHEMBL6310	201286	9	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	202	1	2	2	1.8	COc1ccc2c3c([nH]c2c1)CNCC3	10.1016/j.bmcl.2003.09.027
	11282743	84197	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	CHEMBL222275	84197	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	42	2024	50	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
	56971	2024	50	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
	CHEMBL8412	2024	50	None	-251	18	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2021.128028
	135367403	163682	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4211303	163682	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	127029650	137725	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770581	137725	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	162672312	183174	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4795807	183174	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803872	183174	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	2921525	54570	13	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL1379600	54570	13	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL1613157	54570	13	None	-3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	375	8	1	4	4.7	COc1ccc(CNCCC(c2ccccc2)c2ccc3c(c2)OCO3)cc1	10.1016/j.ejmech.2018.04.010
	10478367	71311	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	CHEMBL196370	71311	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	CHEMBL430500	71311	0	None	-281	7	Human	5.9	pKi	=	5.9	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	439	5	1	6	2.8	COc1ccc(NC(=O)N2CCN(c3ccccc3OC)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	164623862	185413	0	None	-79	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
	CHEMBL4870361	185413	0	None	-79	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
	122483254	137555	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764307	137555	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765844	137555	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	5	0	3	5.6	CC1CC(C)CN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	135367403	163682	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4211303	163682	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	52952099	62239	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	365	5	1	5	3.9	Nc1ccc(N2CCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782796	62239	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	365	5	1	5	3.9	Nc1ccc(N2CCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	18137020	163366	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	360	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207433	163366	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	360	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	137637994	155389	0	None	2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4061131	155389	0	None	2	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	118626120	165225	0	None	-23	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4247770	165225	0	None	-23	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	57400829	68074	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	6	1	4	3.4	O=S(=O)(NCCCN1CCC2CCCCC2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917352	68074	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	6	1	4	3.4	O=S(=O)(NCCCN1CCC2CCCCC2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	11256720	2016	73	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
	9444	2016	73	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
	CHEMBL1083390	2016	73	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
	DB12680	2016	73	None	-60255	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	353	3	1	5	2.5	O=S(=O)(c1cnc2c(c1)cccc2N1CCNCC1)c1ccccc1	10.1016/j.ejmech.2017.12.053
	46233383	197213	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	285	5	0	2	4.6	Cc1cccc(C)c1-c1ccccc1SCCN(C)C	10.1016/j.bmc.2010.01.035
	CHEMBL584429	197213	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	285	5	0	2	4.6	Cc1cccc(C)c1-c1ccccc1SCCN(C)C	10.1016/j.bmc.2010.01.035
	13069624	120077	0	None	-15	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360991	120077	0	None	-15	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3545931	120077	0	None	-15	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	382	5	0	8	0.6	Cn1c(=O)c2c(ncn2CCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	134130447	141763	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	9	0	5	4.5	c1ccc(-c2cc(OCCCCCN3CCN(c4ccccc4)CC3)ncn2)cc1	10.1016/j.bmc.2016.12.039
	CHEMBL3885319	141763	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	9	0	5	4.5	c1ccc(-c2cc(OCCCCCN3CCN(c4ccccc4)CC3)ncn2)cc1	10.1016/j.bmc.2016.12.039
	118728526	117205	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(c4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401489	117205	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(c4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	135367917	163032	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4203526	163032	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	71458649	81004	0	None	-5	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	370	7	1	5	2.3	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159473	81004	0	None	-5	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	370	7	1	5	2.3	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	134153539	153956	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3971383	153956	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3990611	153956	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	72734865	105821	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	CHEMBL3092756	105821	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	CHEMBL3139103	105821	0	None	-39	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	134153539	153956	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3971383	153956	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3990611	153956	0	None	-3	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	390	5	0	3	6.0	Clc1ccc2sc(CCCCN3CCc4c(Cl)cccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	155528967	170816	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	510	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
	CHEMBL4462139	170816	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	510	7	1	5	5.4	O=c1c(-c2ccc(F)cc2)c2ccccn2c(=O)n1CCCCN1CCCC(c2c[nH]c3ccccc23)C1	10.1016/j.ejmech.2019.01.031
	155546350	172965	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2cc(F)c(Cl)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4531898	172965	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2cc(F)c(Cl)cc12	10.1016/j.ejmech.2019.03.017
	135367917	163032	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4203526	163032	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	168288545	191157	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	372	8	3	9	1.1	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5197737	191157	0	None	-31	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	372	8	3	9	1.1	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	44460918	204066	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	299	4	0	3	3.4	CC(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL83090	204066	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	299	4	0	3	3.4	CC(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	49756	202599	9	None	-5	8	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm990550b
	CHEMBL7143	202599	9	None	-5	8	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	232	4	1	2	2.6	COc1ccc2[nH]c(C)c(CCN(C)C)c2c1	10.1021/jm990550b
	136180316	117194	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	362	6	1	4	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401478	117194	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	362	6	1	4	3.1	O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	57399866	71182	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1949974	71182	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1962960	71182	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	156018141	177337	0	None	-36	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	439	9	0	5	3.4	COc1ccccc1N1CCN(CCCCCCN2C(=O)[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3C2=O)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4645292	177337	0	None	-36	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	439	9	0	5	3.4	COc1ccccc1N1CCN(CCCCCCN2C(=O)[C@H]3[C@@H]4CC[C@@H](C4)[C@H]3C2=O)CC1	10.1016/j.bmc.2020.115459
	44352308	116971	0	None	-177	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
	CHEMBL339980	116971	0	None	-177	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
	118728514	117193	0	None	-27	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401477	117193	0	None	-27	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	118728511	117190	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	8	1	5	3.8	Cc1cc2c(=O)[nH]c(CCCCCN3CCN(Cc4ccccc4)CC3)nc2s1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401474	117190	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	8	1	5	3.8	Cc1cc2c(=O)[nH]c(CCCCCN3CCN(Cc4ccccc4)CC3)nc2s1	10.1016/j.bmcl.2015.02.042
	162671033	183163	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4793296	183163	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4803797	183163	0	None	-4	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	4	3.0	O=C(CCCN1CCN(c2cccnc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	11112531	101694	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL302723	101694	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
	11112531	101694	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL302723	101694	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	417	6	1	3	4.8	Cc1cccc(C)c1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	142601318	184953	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	184953	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	2853434	117415	14	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	386	3	1	2	4.9	O=S(=O)(c1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	CHEMBL3403335	117415	14	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	386	3	1	2	4.9	O=S(=O)(c1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	134145143	150189	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	4	1	4	2.8	CNCc1cc2c(c(-c3ccccc3OC)c1)OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3956286	150189	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	271	4	1	4	2.8	CNCc1cc2c(c(-c3ccccc3OC)c1)OCO2	10.1016/j.ejmech.2016.07.029
	11132982	51616	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL158592	51616	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)c1ccccc1O	10.1021/jm020994z
	90654674	109593	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	500	6	1	5	3.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235746	109593	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	500	6	1	5	3.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	164619075	185591	0	None	-9	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	413	7	0	5	2.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4872713	185591	0	None	-9	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	413	7	0	5	2.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2021.128028
	142601318	184953	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	184953	0	None	6	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	25107581	192020	0	None	-14	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	CHEMBL521687	192020	0	None	-14	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	10378785	16576	0	None	-5	4	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3oc(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL124419	16576	0	None	-5	4	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3oc(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	46206345	124075	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
	CHEMBL3640613	124075	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
	46206345	124075	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
	CHEMBL3640613	124075	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.5	COc1ccc(-c2ccccc2)cc1OC1CCNCC1	nan
	46233449	200298	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	287	6	0	5	2.3	COc1cccc(OC)c1-c1ccnc(CCN(C)C)n1	10.1016/j.bmc.2010.01.035
	CHEMBL608138	200298	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	287	6	0	5	2.3	COc1cccc(OC)c1-c1ccnc(CCN(C)C)n1	10.1016/j.bmc.2010.01.035
	164618510	185341	0	None	-8	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	4.1	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4869198	185341	0	None	-8	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	4.1	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	49862237	14823	0	None	6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
	CHEMBL1209157	14823	0	None	6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
	11783562	54102	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
	CHEMBL160906	54102	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
	5074	3268	75	None	-38	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	97	3268	75	None	-38	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	CHEMBL267777	3268	75	None	-38	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	DB12693	3268	75	None	-38	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	72711488	102099	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
	CHEMBL2431041	102099	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
	CHEMBL3040835	102099	0	None	2	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	382	9	1	5	2.4	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2cccnc12	10.1021/jm400766k
	76332577	105784	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121419	105784	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139022	105784	0	None	7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	409	5	0	3	6.1	CC(C)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	71451458	81017	0	None	-3	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	5	3.5	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159486	81017	0	None	-3	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	5	3.5	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
	118731358	117678	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	530	10	0	4	5.4	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409041	117678	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	530	10	0	4	5.4	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	25107716	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	8436	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	CHEMBL522691	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1021/jm3003679
	11393128	182269	0	None	-7	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4791646	182269	0	None	-7	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	25107716	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
	8436	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL522691	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assayDisplacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.ejmech.2016.05.005
	66801344	158863	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4100951	158863	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	122178699	120839	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL3581245	120839	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
	164614709	184616	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4857665	184616	0	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	6	0	4	4.1	O=C1c2ccc(Cl)cc2CC1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	164622973	185531	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4871868	185531	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	25107716	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	8436	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	CHEMBL522691	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmc.2014.01.016
	44408630	138765	0	None	100	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	376	7	0	5	3.9	CC(C)(CCCN1CCCC(c2cnco2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL379238	138765	0	None	100	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	376	7	0	5	3.9	CC(C)(CCCN1CCCC(c2cnco2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	71678857	146726	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1cccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3928716	146726	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in CHO-K1 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1cccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.ejmech.2016.07.029
	92042877	148631	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3943658	148631	1	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	241	4	1	2	3.4	CNCc1ccc(C)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	25107716	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
	8436	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
	CHEMBL522691	2309	35	None	-3	7	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrsDisplacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs	ChEMBL	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	10.1016/j.bmcl.2013.09.025
	56944287	111599	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	9	1	6	4.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289998	111599	0	None	-4	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	9	1	6	4.8	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	122178699	120839	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581245	120839	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	145946966	167025	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4209888	167025	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300899	167025	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	164622973	185531	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4871868	185531	0	None	-6	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	397	6	0	4	4.5	CC1(CCCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	162670302	182141	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	419	8	1	6	3.8	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4789865	182141	0	None	19	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	419	8	1	6	3.8	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	71062035	92670	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442994	92670	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71062035	92670	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442994	92670	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	472	11	1	5	4.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	11785183	84275	0	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
	CHEMBL222755	84275	0	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
	11785183	84275	0	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222755	84275	0	None	1	5	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	1	3	4.9	Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	135458392	96963	5	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	0	2	3	2.2	CNC1=Nc2cccc(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
	CHEMBL269964	96963	5	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	0	2	3	2.2	CNC1=Nc2cccc(Cl)c2C(C)N1	10.1016/j.bmcl.2007.10.080
	46204728	124035	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL3640575	124035	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	46204728	124035	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL3640575	124035	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1ccccc1-c1ccc(Cl)c(OC2CNC2)c1	nan
	CHEMBL5084167	213117	0	None	-63	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.1c00497
	134137560	142161	0	None	6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3892201	142161	0	None	6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	485	11	1	4	5.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	162673308	182517	0	None	25	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	443	8	1	6	3.8	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4794688	182517	0	None	25	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	443	8	1	6	3.8	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
	18377409	204317	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	1	3	4.0	O=C1Nc2cccc3c2C1(CCCCN1CCc2occc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL85249	204317	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	1	3	4.0	O=C1Nc2cccc3c2C1(CCCCN1CCc2occc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	16006492	97007	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL270177	97007	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	10597140	62701	0	None	25	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL1788231	62701	0	None	25	6	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.Binding affinity toward 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]-5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	5074	3268	75	None	-38	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
	97	3268	75	None	-38	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
	CHEMBL267777	3268	75	None	-38	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
	DB12693	3268	75	None	-38	30	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1016/s0960-894x(00)00166-9
	10767321	97804	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1021/jm970519e
	CHEMBL274595	97804	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1021/jm970519e
	10767321	97804	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL274595	97804	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	486	6	0	4	4.4	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cc(Br)c(Br)s2)CC1	10.1016/s0960-894x(00)00166-9
	10715998	44958	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	CHEMBL152595	44958	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	44368754	46623	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	561	7	0	4	6.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cc(Br)c(Br)cc2-c2cccs2)CC1	10.1021/jm030841r
	CHEMBL154090	46623	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	561	7	0	4	6.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cc(Br)c(Br)cc2-c2cccs2)CC1	10.1021/jm030841r
	142601328	184410	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184410	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	162664339	181536	0	None	-14	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
	CHEMBL4782149	181536	0	None	-14	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
	24865727	192501	0	None	-10	11	Human	7.8	pKi	=	7.8	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	479	7	0	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	CHEMBL522708	192501	0	None	-10	11	Human	7.8	pKi	=	7.8	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	479	7	0	5	4.4	Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	5074	3268	75	None	-74	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
	97	3268	75	None	-74	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
	CHEMBL267777	3268	75	None	-74	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
	DB12693	3268	75	None	-74	30	Human	7.8	pKi	=	7.8	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030841r
	76284721	104516	0	None	27	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	480	10	1	5	3.9	O=C(CCOCCN1CCN(c2ccccc2-c2ccc(F)cc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113597	104516	0	None	27	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	480	10	1	5	3.9	O=C(CCOCCN1CCN(c2ccccc2-c2ccc(F)cc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	72550645	113577	0	None	-2	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	505	11	1	4	6.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326993	113577	0	None	-2	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	505	11	1	4	6.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	16006492	97007	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL270177	97007	7	None	-3	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	195	0	2	3	2.0	CC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	46205696	124058	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
	CHEMBL3640597	124058	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
	71459269	82533	0	None	-660	8	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
	CHEMBL2181166	82533	0	None	-660	8	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
	45273816	194098	0	None	5	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	428	8	3	3	3.5	Cc1cccc(S(=O)(=O)NCCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	CHEMBL557740	194098	0	None	5	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	428	8	3	3	3.5	Cc1cccc(S(=O)(=O)NCCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	1220	186	46	None	-75	45	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	31	186	46	None	-75	45	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	7	186	46	None	-75	45	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	CHEMBL56	186	46	None	-75	45	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	46205696	124058	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
	CHEMBL3640597	124058	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccc(-c2ccccc2)cc1C1CCN(C)C1	nan
	24873257	179666	0	None	-10	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4750414	179666	0	None	-10	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	11312173	181519	0	None	-151	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4782005	181519	0	None	-151	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	66801430	157160	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	7	2	3	4.9	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4081987	157160	0	None	-2	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	7	2	3	4.9	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	66801625	157728	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	7	2	3	5.7	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	CHEMBL4088925	157728	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	493	7	2	3	5.7	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	156021073	177582	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	CHEMBL4649078	177582	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	335	2	1	4	4.4	CCCN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	90644077	111582	0	None	-10	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	7	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3289981	111582	0	None	-10	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	7	3.5	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	168279281	190418	0	None	-26	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	342	7	3	8	1.1	Nc1nc(N)nc(NCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5186821	190418	0	None	-26	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	342	7	3	8	1.1	Nc1nc(N)nc(NCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	71456677	80734	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	7	1	3	4.8	Cc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2C(C)(C)C)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158027	80734	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	7	1	3	4.8	Cc1ccccc1C(=O)NCC1CCN(CCOc2ccccc2C(C)(C)C)CC1	10.1016/j.ejmech.2012.07.043
	155568794	175514	0	None	-53	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	336	7	3	4	3.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cn[nH]c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4591410	175514	0	None	-53	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	336	7	3	4	3.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cn[nH]c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	122181344	121359	0	None	-4	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590096	121359	0	None	-4	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	164608896	183828	0	None	-223	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4846146	183828	0	None	-223	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	162666977	183143	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4787400	183143	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803559	183143	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	122483246	137557	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763582	137557	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765846	137557	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	127049059	140269	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3818935	140269	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
	52952202	62242	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	5	0	5	4.6	N#Cc1ccc(N2CCCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782800	62242	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	5	0	5	4.6	N#Cc1ccc(N2CCCN(CCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	155558408	174173	0	None	-16	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(Cl)ccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4560883	174173	0	None	-16	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(Cl)ccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	71462776	82536	0	None	-125	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181169	82536	0	None	-125	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
	90654690	109574	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	418	9	1	5	2.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235727	109574	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	418	9	1	5	2.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	53361626	66079	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851948	66079	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216277	66079	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2011.04.060
	122483246	137557	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763582	137557	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765846	137557	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	410	6	0	3	6.5	O=C(CCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	162662435	183124	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4780228	183124	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803308	183124	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	9	2	5	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	11260739	84700	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	CHEMBL224929	84700	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	127036186	136876	0	None	-4	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3753318	136876	0	None	-4	19	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
	44324535	12986	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL1190414	12986	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL540821	12986	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	4	3.2	CC(=O)c1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	155547197	173013	0	None	-758	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4533305	173013	0	None	-758	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	6918515	2564	33	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
	71	2564	33	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
	CHEMBL7318	2564	33	None	-4	7	Human	6.8	pKi	=	6.8	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10.1021/jm990550b
	55479093	80995	1	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	366	7	1	5	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159464	80995	1	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	366	7	1	5	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	46206018	124065	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
	CHEMBL3640604	124065	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
	46206018	124065	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
	CHEMBL3640604	124065	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	265	2	0	1	4.4	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1C	nan
	11739679	169274	0	None	-776	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSDBinding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSD	ChEMBL	353	3	2	5	2.8	Nc1ccc(S(=O)(=O)n2cc(C3=CCNCC3)c3ccccc32)cc1	10.1016/j.bmcl.2004.10.064
	CHEMBL444015	169274	0	None	-776	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSDBinding affinity against human cloned 5-hydroxytryptamine 7 receptor stably expressed in CHO cells using [3H]LSD	ChEMBL	353	3	2	5	2.8	Nc1ccc(S(=O)(=O)n2cc(C3=CCNCC3)c3ccccc32)cc1	10.1016/j.bmcl.2004.10.064
	168298474	192107	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	384	8	0	5	3.9	CCOCC(Oc1c(C)cccc1C)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
	CHEMBL5219968	192107	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	384	8	0	5	3.9	CCOCC(Oc1c(C)cccc1C)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
	57399090	68064	0	None	-8	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917342	68064	0	None	-8	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ncccc3c2)CC1	10.1016/j.bmc.2011.09.044
	168284197	190252	0	None	-12	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	515	12	4	9	3.6	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5184538	190252	0	None	-12	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	515	12	4	9	3.6	COc1ccccc1N1CCN(CCCCNc2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
	888197	76367	4	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	241	5	0	2	3.3	CN(C)CCOc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
	CHEMBL20666	76367	4	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	241	5	0	2	3.3	CN(C)CCOc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
	10430623	18473	22	None	-1412	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	CHEMBL1277105	18473	22	None	-1412	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	162669046	183151	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4789585	183151	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803681	183151	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2cccc(C(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	86288950	112133	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL3233666	112133	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL3302931	112133	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	452	8	0	4	3.9	CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	91937907	167068	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4218586	167068	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4301638	167068	0	None	17	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	368	7	0	4	4.2	COc1ccccc1N1CCN(CCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	122483290	137558	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765511	137558	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765847	137558	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	44461064	203867	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	287	4	0	4	2.3	COc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81449	203867	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	287	4	0	4	2.3	COc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	168268929	189427	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	456	9	5	7	4.4	Nc1nc(NCCNc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5171734	189427	0	None	-3	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	456	9	5	7	4.4	Nc1nc(NCCNc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	12005903	50935	12	None	-117	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	482	5	0	7	4.0	CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1	10.1016/j.bmcl.2015.03.049
	CHEMBL1580288	50935	12	None	-117	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	482	5	0	7	4.0	CCS(=O)(=O)c1nc(S(=O)(=O)c2ccc(Cl)cc2)c(N2CCc3ccccc3C2)s1	10.1016/j.bmcl.2015.03.049
	44460739	203828	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2c(ccn2CCN2CCN3CCCCC3C2)c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81069	203828	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2c(ccn2CCN2CCN3CCCCC3C2)c1	10.1016/s0960-894x(02)00438-9
	42626289	147535	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1	10.1021/jm8014553
	CHEMBL393492	147535	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1	10.1021/jm8014553
	11292933	56085	39	None	-794	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631540	56085	39	None	-794	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL5085390	213181	0	None	-12	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	155528865	170813	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4462108	170813	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
	162645252	183033	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4743284	183033	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4802393	183033	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	1150	3805	116	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
	125	3805	116	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
	CHEMBL6640	3805	116	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
	DB08653	3805	116	None	-6	25	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1016/j.ejmech.2019.111705
	122483290	137558	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765511	137558	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765847	137558	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.9	O=C(CCCCCN1CCC(c2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	145967457	163788	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2cccc(C(F)(F)F)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4212698	163788	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2cccc(C(F)(F)F)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	12843124	10152	25	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1ccc2c(c1)CC[C@@H](N)C2	10.1021/jm030826m
	CHEMBL1161325	10152	25	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	177	1	1	2	1.5	COc1ccc2c(c1)CC[C@@H](N)C2	10.1021/jm030826m
	9891002	106911	0	None	-1584	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
	CHEMBL318018	106911	0	None	-1584	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
	10785644	96644	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1021/jm970519e
	CHEMBL267543	96644	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1021/jm970519e
	10785644	96644	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1016/s0960-894x(00)00166-9
	CHEMBL267543	96644	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@@H](CCN1CCC[C@@H](C)C1)N(C)S(=O)(=O)c1cccc2ccccc12	10.1016/s0960-894x(00)00166-9
	44368383	119199	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	CHEMBL347511	119199	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@@H](C)CCN1CCC[C@@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	127050632	140199	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3818124	140199	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
	127049059	140269	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3818935	140269	0	None	-154	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	404	6	1	5	3.6	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3o1)CC2	10.1016/j.bmc.2016.06.011
	162663829	183128	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4779965	183128	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803379	183128	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	439	8	2	5	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	155528865	170813	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4462108	170813	0	None	-33	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	347	6	0	3	4.0	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cn3)CC2)cc1	10.1016/j.bmc.2020.115943
	164623862	185413	0	None	-79	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
	CHEMBL4870361	185413	0	None	-79	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	351	6	0	5	2.8	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc21	10.1016/j.ejmech.2021.113243
	127050632	140199	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3818124	140199	0	None	-89	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	6	1	5	4.7	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.06.011
	44393022	64492	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cncc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182006	64492	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cncc(NCCc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	168273329	189964	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5180129	189964	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
	10106205	205398	1	None	1	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
	CHEMBL92221	205398	1	None	1	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030030n
	44461066	103663	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	4	0	3	3.6	Brc1ccc2ccn(CCN3CCCN(C4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL309523	103663	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	4	0	3	3.6	Brc1ccc2ccn(CCN3CCCN(C4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	127026751	137142	0	None	23	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758622	137142	0	None	23	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	90178632	144883	0	None	9	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	468	10	1	5	4.1	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3914155	144883	0	None	9	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	468	10	1	5	4.1	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	134151980	152644	0	None	8	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	570	14	1	6	5.1	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3977072	152644	0	None	8	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	570	14	1	6	5.1	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
	71456783	81011	0	None	1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159480	81011	0	None	1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	71449644	81015	0	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
	CHEMBL2159484	81015	0	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
	118731357	117677	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	516	9	0	4	5.0	O=C([C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409040	117677	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	516	9	0	4	5.0	O=C([C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	156016485	177189	0	None	-15	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	0	7	4.7	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2cccc3c2n1CCC3	10.1016/j.bmc.2020.115459
	CHEMBL4642981	177189	0	None	-15	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	0	7	4.7	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2cccc3c2n1CCC3	10.1016/j.bmc.2020.115459
	57384073	76837	0	None	-19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL2079256	76837	0	None	-19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	139488539	170848	0	None	19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	307	2	1	2	4.0	CCn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4462820	170848	0	None	19	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	307	2	1	2	4.0	CCn1cncc1-c1c[nH]c2ccc(Br)c(F)c12	10.1016/j.ejmech.2019.03.017
	156009593	176585	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	303	2	0	1	4.6	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4634558	176585	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	303	2	0	1	4.6	CN(C)C1CCc2c(cccc2-c2ccc(F)cc2Cl)C1	10.1016/j.bmc.2019.115262
	142601328	184410	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184410	0	None	39	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	155557720	174065	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	494	10	1	7	3.2	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4558286	174065	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	494	10	1	7	3.2	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	54758297	65661	0	None	15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	349	6	1	3	3.7	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
	CHEMBL1836856	65661	0	None	15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	349	6	1	3	3.7	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
	135367857	164041	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164041	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	132604118	181401	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	420	8	1	7	2.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4780452	181401	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	420	8	1	7	2.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	10106205	205398	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030826m
	CHEMBL92221	205398	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1021/jm030826m
	135367857	164041	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164041	0	None	1	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	10106205	205398	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1016/s0960-894x(02)00925-3
	CHEMBL92221	205398	1	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	251	2	2	3	3.0	Cc1c(NC2=NCCN2)cccc1-c1ccccc1	10.1016/s0960-894x(02)00925-3
	11025015	49914	0	None	-3	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
	CHEMBL157081	49914	0	None	-3	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
	25107518	186691	0	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysisDisplacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysis	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL492871	186691	0	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysisDisplacement of [3H]-SB-26997 from human 5-HT7A receptor expressed in HEK293 cell membranes after 60 mins by microbeta counting analysis	ChEMBL	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	44324628	111869	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1cccs1	10.1016/s0960-894x(02)00925-3
	CHEMBL329548	111869	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1cccs1	10.1016/s0960-894x(02)00925-3
	90656695	110494	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CN(CCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262429	110494	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CN(CCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	168282260	190399	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysisBinding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	232	3	0	4	2.6	COc1ccc(-c2c([N+](=O)[O-])ccn2C)cc1	10.1021/acs.jmedchem.2c00633
	CHEMBL5186652	190399	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysisBinding affinity to human 5-HT7 receptor transfected by pcDNA3.1(+) vector in HEK293 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	232	3	0	4	2.6	COc1ccc(-c2c([N+](=O)[O-])ccn2C)cc1	10.1021/acs.jmedchem.2c00633
	11595790	65655	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	368	6	1	4	3.2	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
	CHEMBL1836790	65655	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	368	6	1	4	3.2	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccccn2)CC1	10.1021/jm200547z
	11646498	102018	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL2431051	102018	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL3040382	102018	0	None	-7	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	9803482	202559	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	443	7	1	4	5.0	COCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL71224	202559	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	443	7	1	4	5.0	COCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	127051845	140185	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3817898	140185	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	50878551	90300	60	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90300	60	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	156012890	176859	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4638770	176859	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
	162645252	183033	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4743284	183033	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4802393	183033	0	None	-2	7	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	389	7	0	3	5.0	Fc1ccc(CCCCN2CCN(c3cccc(-c4ccccc4)n3)CC2)cc1	10.1016/j.bmc.2020.115943
	44424661	144002	0	None	-8	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	484	10	0	10	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL390734	144002	0	None	-8	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	484	10	0	10	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	118706287	120007	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310114	120007	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545466	120007	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	42625359	186254	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCC(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL489448	186254	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCC(c2ccccc2)CC1	10.1021/jm8014553
	136216703	78480	0	None	-79	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity against 5-hydroxytryptamine 7 receptorBinding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	482	2	4	7	4.0	N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2	10.1016/s0960-894x(99)00075-x
	CHEMBL2112936	78480	0	None	-79	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity against 5-hydroxytryptamine 7 receptorBinding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	482	2	4	7	4.0	N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2	10.1016/s0960-894x(99)00075-x
	9796627	96192	0	None	-54	8	Human	5.8	pKi	=	5.8	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	308	4	1	4	3.1	CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12	10.1021/jm010943m
	CHEMBL263700	96192	0	None	-54	8	Human	5.8	pKi	=	5.8	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	308	4	1	4	3.1	CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12	10.1021/jm010943m
	15560577	184749	6	None	-31	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4859858	184749	6	None	-31	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	23906630	117413	4	None	-2	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	1	2	2.9	O=S(=O)(c1ccc(F)cc1)N1CC=c2ccccc2=C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	CHEMBL3403333	117413	4	None	-2	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	1	2	2.9	O=S(=O)(c1ccc(F)cc1)N1CC=c2ccccc2=C1c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	155566439	175215	0	None	-69	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2019.06.022
	CHEMBL4584325	175215	0	None	-69	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccc(OCc2nc(N)nc(N3CCN(C)CC3)n2)cc1	10.1016/j.ejmech.2019.06.022
	45273807	194121	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	400	6	3	3	2.7	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	CHEMBL558025	194121	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	400	6	3	3	2.7	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	71451441	80947	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	6	1	5	3.6	O=C(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc2c(c1)OCCO2	10.1016/j.ejmech.2012.07.043
	CHEMBL2159320	80947	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	6	1	5	3.6	O=C(NC1CCN(CCOc2cccc(Cl)c2Cl)C1)c1ccc2c(c1)OCCO2	10.1016/j.ejmech.2012.07.043
	155552826	173510	0	None	37	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	269	3	1	4	2.8	CCn1cncc1-c1c[nH]c2ccc(C(=O)OC)cc12	10.1039/C8MD00313K
	CHEMBL4544802	173510	0	None	37	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	269	3	1	4	2.8	CCn1cncc1-c1c[nH]c2ccc(C(=O)OC)cc12	10.1039/C8MD00313K
	53248361	61738	0	None	-104	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	568	7	0	5	3.2	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1	10.1021/jm1009956
	CHEMBL1774991	61738	0	None	-104	7	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	568	7	0	5	3.2	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1	10.1021/jm1009956
	90656686	110481	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	7	1	4	3.3	CC(=O)Nc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262416	110481	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	7	1	4	3.3	CC(=O)Nc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	90656679	110480	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	6	0	3	4.1	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Br)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262415	110480	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	6	0	3	4.1	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Br)c1	10.1016/j.ejmech.2014.04.034
	90656674	110470	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	5	1	4	2.7	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262399	110470	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	311	5	1	4	2.7	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	46233351	197486	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	270	5	0	3	3.3	Cc1cccc(C)c1-c1cccc(OCCN(C)C)n1	10.1016/j.bmc.2010.01.035
	CHEMBL589524	197486	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	270	5	0	3	3.3	Cc1cccc(C)c1-c1cccc(OCCN(C)C)n1	10.1016/j.bmc.2010.01.035
	127027390	137301	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	0	4	3.5	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759927	137301	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	0	4	3.5	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	168293886	191572	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	488	8	0	4	4.5	O=S1(=O)N(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2N1CCC3	10.1016/j.ejmech.2022.114319
	CHEMBL5204088	191572	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	488	8	0	4	4.5	O=S1(=O)N(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2N1CCC3	10.1016/j.ejmech.2022.114319
	155531065	171037	0	None	-229	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	332	6	3	3	4.5	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4465414	171037	0	None	-229	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	332	6	3	3	4.5	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	1355	1972	82	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
	142	1972	82	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
	CHEMBL478	1972	82	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
	DB12110	1972	82	None	-14	16	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.ejmech.2022.114319
	44461052	204150	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	391	4	0	3	4.5	CC(C)(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL83802	204150	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	391	4	0	3	4.5	CC(C)(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	90654689	109573	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	404	8	1	5	2.2	CSc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235726	109573	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	404	8	1	5	2.2	CSc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	127028634	137316	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	7	1	4	3.0	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3760121	137316	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	7	1	4	3.0	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	44424671	142920	0	None	-2	3	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	369	4	1	7	0.2	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL389842	142920	0	None	-2	3	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	369	4	1	7	0.2	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	137650961	156779	0	None	3	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4077538	156779	0	None	3	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	145982506	164832	0	None	-11	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238029	164832	0	None	-11	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	145987559	166584	0	None	26	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	441	7	2	5	2.5	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4290738	166584	0	None	26	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	441	7	2	5	2.5	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	44341131	9369	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	393	5	1	6	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3oc(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL111956	9369	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	393	5	1	6	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3oc(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	168291978	191405	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	482	6	3	7	4.2	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5201719	191405	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	482	6	3	7	4.2	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	118728527	117207	0	None	-7	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	424	8	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(Cc4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401490	117207	0	None	-7	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	424	8	0	6	4.1	Cc1sc2ncn(CCCCCN3CCN(Cc4ccccc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	71678345	89239	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376455	89239	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	24901425	62250	0	None	-10	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	6	2	5	4.5	N#Cc1ccc(N2CCC(NCCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782811	62250	0	None	-10	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	6	2	5	4.5	N#Cc1ccc(N2CCC(NCCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	44460639	162777	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	285	4	0	3	2.8	CCc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL419101	162777	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	285	4	0	3	2.8	CCc1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	155569022	175852	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4592962	175852	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4596261	175852	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	71678345	89239	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376455	89239	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	396	4	0	2	5.7	FC(F)(F)c1cccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)c1	10.1016/j.bmc.2013.02.038
	168268997	189368	0	None	-23	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	410	7	3	8	2.4	Nc1nc(N)nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5170808	189368	0	None	-23	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	410	7	3	8	2.4	Nc1nc(N)nc(NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	168277941	190079	0	None	-7	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	374	9	2	4	1.8	NS(=O)(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	CHEMBL5181868	190079	0	None	-7	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	374	9	2	4	1.8	NS(=O)(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	155519516	175774	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4447659	175774	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595677	175774	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	53322759	56702	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	4.9	FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644272	56702	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	4.9	FC(F)(F)c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	145971390	164071	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4216244	164071	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
	71451345	80744	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	6	1	3	4.4	CC(C)(C)c1ccccc1OCCN1CCC(NC(=O)c2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158037	80744	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	6	1	3	4.4	CC(C)(C)c1ccccc1OCCN1CCC(NC(=O)c2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
	137642224	157534	0	None	-758	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	323	3	2	6	1.3	CN1CCN(c2nc(N)nc(Cc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2022.114645
	CHEMBL4086515	157534	0	None	-758	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	323	3	2	6	1.3	CN1CCN(c2nc(N)nc(Cc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2022.114645
	127027389	137255	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	0	4	4.0	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759570	137255	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	0	4	4.0	CC(C)c1ccccc1OCCN1CC2CC1CN2S(=O)(=O)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	118728506	117187	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	414	8	2	4	3.4	NC(=O)c1ccccc1NC(=O)CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401469	117187	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	414	8	2	4	3.4	NC(=O)c1ccccc1NC(=O)CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	42618261	180959	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	472	8	0	7	4.0	COc1ccc(-n2c(=O)n(CCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	CHEMBL476616	180959	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	472	8	0	7	4.0	COc1ccc(-n2c(=O)n(CCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	56850665	71146	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926749	71146	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962697	71146	0	None	-11	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	162659577	180766	0	None	-17	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4763106	180766	0	None	-17	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
	44324402	13313	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL1192985	13313	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL544315	13313	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	276	2	2	4	2.9	Cc1c(NC2=NCCN2)cccc1-c1cccc(C#N)c1	10.1016/s0960-894x(02)00925-3
	71727066	90820	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401936	90820	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL3215930	90820	0	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	338	3	0	5	2.7	COc1ccc2c(=O)c3cc(CN4CCN(C)CC4)ccc3oc2c1	10.1016/j.bmcl.2013.05.062
	46206023	124070	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640609	124070	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
	46206023	124070	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640609	124070	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(C)cc1-c1ccccc1C1CCNC1	nan
	44461045	104238	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	403	4	0	3	4.7	Brc1ccc2ccn(CCN3CCCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL310594	104238	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	403	4	0	3	4.7	Brc1ccc2ccn(CCN3CCCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	76325347	105901	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121420	105901	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139440	105901	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	439	6	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C(C)C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	127028797	137792	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771309	137792	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	494	6	2	5	3.1	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	127026444	137309	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3760017	137309	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	145985224	164925	0	None	-4	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4240162	164925	0	None	-4	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	71458623	80934	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	6	3.9	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159308	80934	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	6	3.9	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1016/j.ejmech.2012.07.043
	156021535	177600	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4649289	177600	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
	56945043	155852	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4066532	155852	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	156013801	176698	0	None	26	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	1	0	2	3.5	CN(C)c1ccc2c(c1)-c1cccc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL4636329	176698	0	None	26	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	1	0	2	3.5	CN(C)c1ccc2c(c1)-c1cccc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	127051845	140185	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3817898	140185	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	50878551	90300	60	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90300	60	None	1	18	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	73346042	91388	3	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1021/acs.jmedchem.2c00633
	CHEMBL2413153	91388	3	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1021/acs.jmedchem.2c00633
	73346042	91388	3	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	CHEMBL2413153	91388	3	None	-173	17	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	15542627	202499	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	432	7	2	4	3.3	NC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL70869	202499	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	432	7	2	4	3.3	NC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	136152966	95136	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	289	3	2	4	2.9	COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2	10.1016/j.bmcl.2007.10.078
	CHEMBL257744	95136	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	289	3	2	4	2.9	COc1c(Cl)ccc2c1C(C)NC(NCC(F)F)=N2	10.1016/j.bmcl.2007.10.078
	11277147	105847	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092759	105847	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139188	105847	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	162664480	181616	0	None	26	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	441	9	0	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4783043	181616	0	None	26	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	441	9	0	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccccc3C#N)CC2)cc1	10.1016/j.ejmech.2020.112395
	44374298	54098	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	278	5	0	4	3.8	Cc1sc(SCCN(C)C)nc1-c1ccccc1	10.1016/j.bmcl.2003.11.050
	CHEMBL160903	54098	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	278	5	0	4	3.8	Cc1sc(SCCN(C)C)nc1-c1ccccc1	10.1016/j.bmcl.2003.11.050
	145964086	163611	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4210561	163611	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	44439394	144577	0	None	398	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccc(CC2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
	CHEMBL391191	144577	0	None	398	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccc(CC2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
	3377940	91333	21	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	278	2	2	2	3.4	COc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL241098	91333	21	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	278	2	2	2	3.4	COc1cccc(C2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	136152972	94767	0	None	-7	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL256047	94767	0	None	-7	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	168277502	190111	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	468	8	0	5	6.2	S=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
	CHEMBL5182383	190111	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	468	8	0	5	6.2	S=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
	155533534	171308	0	None	-131	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4469537	171308	0	None	-131	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccc(F)cc2)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	90654848	112187	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233673	112187	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304318	112187	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2F)CC1	10.1016/j.ejmech.2014.01.065
	145974184	164060	0	None	50	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
	CHEMBL4216040	164060	0	None	50	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
	145988913	166605	0	None	23	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	475	7	2	5	3.2	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccc(Cl)cc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4291141	166605	0	None	23	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	475	7	2	5	3.2	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCC(Oc3ccc(Cl)cc3)CC2)C1=O	10.1039/C8MD00168E
	18377388	204251	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	394	6	0	3	4.9	CCN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	CHEMBL84660	204251	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	394	6	0	3	4.9	CCN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	71602587	89236	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376448	89236	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	137652044	156613	0	None	2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4075422	156613	0	None	2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	71727064	101922	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
	CHEMBL3039719	101922	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
	CHEMBL3216145	101922	0	None	-3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	372	4	1	5	2.7	O=c1c2ccc(Cl)cc2oc2c(CN3CCN(CCO)CC3)cccc12	10.1016/j.bmcl.2013.05.062
	9872676	77811	0	None	-4365	17	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
	CHEMBL210514	77811	0	None	-4365	17	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
	71602587	89236	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376448	89236	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	12374770	174920	2	None	20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	268	7	2	2	2.5	O=C(CCNCc1ccccc1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
	CHEMBL4577789	174920	2	None	20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	268	7	2	2	2.5	O=C(CCNCc1ccccc1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
	45272864	194865	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	338	5	3	3	1.5	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(C)CC2)c1	10.1016/j.bmcl.2009.06.038
	CHEMBL563760	194865	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	338	5	3	3	1.5	Cc1cccc(S(=O)(=O)NCCNC(=N)N2CCC(C)CC2)c1	10.1016/j.bmcl.2009.06.038
	127029651	137680	0	None	5	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)cc1C	10.1016/j.ejmech.2016.02.024
	CHEMBL3770110	137680	0	None	5	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)cc1C	10.1016/j.ejmech.2016.02.024
	CHEMBL5080719	212920	0	None	-64	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3o2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	155561915	175886	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4585051	175886	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4596544	175886	0	None	-109	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2C(F)(F)F)CC1	10.1016/j.bmc.2019.06.028
	71460468	80999	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	7	1	4	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc3ccccc3n2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159468	80999	0	None	-5	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	7	1	4	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc3ccccc3n2)C1	10.1016/j.ejmech.2012.07.043
	118729733	117418	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	394	4	1	3	5.4	O=S(=O)(Nc1ccccc1-c1nccc2ccccc12)c1ccc(Cl)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403338	117418	0	None	-4	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	394	4	1	3	5.4	O=S(=O)(Nc1ccccc1-c1nccc2ccccc12)c1ccc(Cl)cc1	10.1016/j.bmcl.2015.03.049
	90654702	109586	0	None	-44	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	440	8	1	4	3.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235739	109586	0	None	-44	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	440	8	1	4	3.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	164615095	184354	0	None	-13	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	414	7	0	6	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4853700	184354	0	None	-13	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	414	7	0	6	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2021.128028
	11675876	186921	0	None	-54	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL494316	186921	0	None	-54	3	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	13069598	120090	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360998	120090	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546116	120090	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	90656680	110479	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	343	6	0	3	4.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262414	110479	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	343	6	0	3	4.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2014.04.034
	90469114	183830	0	None	-588	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	426	3	1	6	3.5	O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	CHEMBL4846153	183830	0	None	-588	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	426	3	1	6	3.5	O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	42618258	189133	0	None	-47	2	Human	4.8	pKi	=	4.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	0	5	4.2	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3C)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL515789	189133	0	None	-47	2	Human	4.8	pKi	=	4.8	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	0	5	4.2	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3C)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	11697434	129934	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2005.05.059
	CHEMBL368044	129934	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2005.05.059
	10499156	113579	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.2c00633
	CHEMBL332701	113579	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	366	6	0	4	3.0	COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.2c00633
	10084076	97454	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
	CHEMBL27251	97454	0	None	1	9	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm030030n
	68788	205863	9	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	CHEMBL95067	205863	9	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	134138168	147146	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147146	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	76325351	105785	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121437	105785	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139023	105785	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	76336179	105904	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	CHEMBL3121421	105904	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	CHEMBL3139443	105904	0	None	18	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	4	0	3	5.6	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	137653850	158487	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4096866	158487	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2016.02.024
	90654686	109605	0	None	21	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	461	7	1	6	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235758	109605	0	None	21	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	461	7	1	6	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	168275477	189847	0	None	263	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	388	9	5	7	3.1	Nc1nc(NCCNc2ccccc2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5178499	189847	0	None	263	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	388	9	5	7	3.1	Nc1nc(NCCNc2ccccc2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	127037922	136450	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	508	10	0	4	5.4	O=S(=O)(c1ccc(F)cc1)N(CC1CC1)C1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3745853	136450	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	508	10	0	4	5.4	O=S(=O)(c1ccc(F)cc1)N(CC1CC1)C1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
	127041258	136543	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747114	136543	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	8	0	4	4.1	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.022
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2012.07.043
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.07.027
	118731348	117669	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	10	1	4	3.9	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409032	117669	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	10	1	4	3.9	NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2014.12.041
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2020.112437
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2018.01.093
	139488740	169570	0	None	97	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	258	2	2	3	1.8	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4444268	169570	0	None	97	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	258	2	2	3	1.8	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.01.031
	156020374	177478	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2cccc(F)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4647335	177478	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)C1CCc2c(cccc2-c2cccc(F)c2)C1	10.1016/j.bmc.2019.115262
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C8MD00168E
	11358099	179815	0	None	-17	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4752099	179815	0	None	-17	4	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	56944951	156084	0	None	-6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	CHEMBL4069237	156084	0	None	-6	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	7	2	3	5.4	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	71061607	92675	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442999	92675	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71061607	92675	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442999	92675	0	None	48	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccncc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.05.062
	10084076	97454	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm9911433
	CHEMBL27251	97454	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm9911433
	10084076	97454	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm0108505
	CHEMBL27251	97454	0	None	-1	9	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	262	0	1	2	2.8	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N	10.1021/jm0108505
	134137104	142148	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3892079	142148	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	402	6	0	4	5.0	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C	10.1016/j.ejmech.2016.07.029
	134138168	147146	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3931889	147146	0	None	-1	10	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1016/j.ejmech.2016.07.029
	11277147	105847	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3092759	105847	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3139188	105847	0	None	-9	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	11697434	129934	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL368044	129934	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	419	6	0	6	3.9	COC(=O)c1cccc(C)c1-n1ccc(CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmcl.2007.03.054
	66801120	111609	0	None	-5	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	7	1	5	5.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3290007	111609	0	None	-5	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	7	1	5	5.3	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	135398737	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	38	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	722	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	CHEMBL42	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	DB00363	942	89	None	-13	92	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2014.11.008
	1342	36	42	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
	3	36	42	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
	CHEMBL277120	36	42	None	-13	19	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030826m
	162661196	180869	0	None	-24	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4764468	180869	0	None	-24	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
	18663036	81394	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	CHEMBL2164344	81394	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	134133483	142665	0	None	5	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	614	16	1	7	5.5	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3896355	142665	0	None	5	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	614	16	1	7	5.5	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	44266317	206195	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	349	4	0	3	4.4	O=C1CC(CN2CCC(Oc3ccccc3)CC2)CCc2ccccc21	10.1016/s0960-894x(03)00077-5
	CHEMBL9696	206195	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	349	4	0	3	4.4	O=C1CC(CN2CCC(Oc3ccccc3)CC2)CCc2ccccc21	10.1016/s0960-894x(03)00077-5
	117209858	183961	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	183961	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL5080955	212930	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(Cl)c1	10.1021/acs.jmedchem.1c00497
	122196381	123763	0	None	-7	6	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	485	8	0	6	6.3	Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
	CHEMBL3634821	123763	0	None	-7	6	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	485	8	0	6	6.3	Fc1ccc2c(C3CCN(CCCOc4ccc(Cc5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
	156017272	177068	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	287	2	0	1	4.1	CN(C)C1CCc2c(cccc2-c2cc(F)cc(F)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4641478	177068	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	287	2	0	1	4.1	CN(C)C1CCc2c(cccc2-c2cc(F)cc(F)c2)C1	10.1016/j.bmc.2019.115262
	156019520	177415	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4646359	177415	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	257	2	0	2	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2cccs2)C1	10.1016/j.bmc.2019.115262
	66800959	156884	0	None	-8	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	413	6	2	3	3.7	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4078873	156884	0	None	-8	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	413	6	2	3	3.7	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	118706296	120001	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310119	120001	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545441	120001	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	71151588	117742	0	None	-1778	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	518	9	1	7	3.6	NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.ejmech.2014.12.045
	CHEMBL3409256	117742	0	None	-1778	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells	ChEMBL	518	9	1	7	3.6	NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1	10.1016/j.ejmech.2014.12.045
	66801333	111583	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	7	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3289982	111583	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	7	3.9	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	46205702	124063	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3640602	124063	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	46205702	124063	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	CHEMBL3640602	124063	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	257	2	1	1	4.1	Clc1ccc(-c2ccccc2C2CCNC2)cc1	nan
	2948971	72849	9	None	-25	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	397	2	3	1	5.6	O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	CHEMBL2011865	72849	9	None	-25	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	397	2	3	1	5.6	O=C1Nc2ccc(Cl)cc2C1(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12	10.1016/j.bmcl.2015.03.049
	134131265	141642	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	8	0	5	5.0	Cc1nc(OCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
	CHEMBL3883995	141642	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	8	0	5	5.0	Cc1nc(OCCCCCN2CCN(c3ccc(Cl)cc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
	44324602	205686	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	3	4.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(C)C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL94056	205686	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	293	3	2	3	4.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(C)C)c1	10.1016/s0960-894x(02)00925-3
	44460744	204000	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	6	0	4	3.9	CN1CCCN(CCn2ccc3ccc(OCc4ccccc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL82550	204000	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	363	6	0	4	3.9	CN1CCCN(CCn2ccc3ccc(OCc4ccccc4)cc32)CC1	10.1016/s0960-894x(02)00438-9
	44424669	85283	0	None	-3	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	412	6	1	8	0.3	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL228939	85283	0	None	-3	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	412	6	1	8	0.3	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	168291393	191386	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	338	8	2	3	2.7	NC(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	CHEMBL5201464	191386	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	338	8	2	3	2.7	NC(=O)NCCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	155515408	175748	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4442062	175748	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595453	175748	0	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	491	8	0	3	5.9	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Br)cc2)CC1	10.1016/j.bmc.2019.06.028
	23369450	180980	2	None	-72	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	352	5	1	5	2.2	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL476822	180980	2	None	-72	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	352	5	1	5	2.2	COc1ccccc1N1CCN(CCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	53377140	66057	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851835	66057	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216729	66057	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2011.04.060
	155515890	169424	0	None	-5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	414	8	0	4	4.6	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4442385	169424	0	None	-5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	414	8	0	4	4.6	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	11667626	102098	0	None	-11	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL2431042	102098	0	None	-11	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL3040827	102098	0	None	-11	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	135398745	2858	108	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
	47	2858	108	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
	CHEMBL715	2858	108	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
	DB00334	2858	108	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2012.07.043
	118728512	117191	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	423	8	1	4	5.3	Cc1sc2nc(CCCCCN3CCC(Cc4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401475	117191	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	423	8	1	4	5.3	Cc1sc2nc(CCCCCN3CCC(Cc4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	23151734	103468	0	None	-467	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092758	103468	0	None	-467	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	71602586	89235	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
	CHEMBL2376447	89235	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
	168281784	190343	0	None	-30	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	429	8	0	6	4.0	O=c1n(CCCCCCN2CCN(c3cccc4ccccc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5185787	190343	0	None	-30	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	429	8	0	6	4.0	O=c1n(CCCCCCN2CCN(c3cccc4ccccc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	11432215	83869	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)CCCC2NC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	CHEMBL221453	83869	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccc2c(c1)CCCC2NC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	164619236	185117	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4865591	185117	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	72549767	113560	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	429	8	1	4	4.2	COc1ccccc1N1CCN(CCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326976	113560	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	429	8	1	4	4.2	COc1ccccc1N1CCN(CCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	71602586	89235	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
	CHEMBL2376447	89235	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1OC	10.1016/j.bmc.2013.02.038
	90654696	109580	0	None	-35	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	374	7	2	5	1.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235733	109580	0	None	-35	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	374	7	2	5	1.2	NC(=O)[C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
	42618257	181004	0	None	-11	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL477066	181004	0	None	-11	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1N1CCN(CCn2c(=O)n(-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	57400830	68080	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917358	68080	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	429	8	0	4	4.5	CCN(CCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	164619236	185117	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4865591	185117	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	6	1	5	2.6	O=C1CCc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	162676036	183193	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4798934	183193	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804093	183193	0	None	-22	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	410	9	2	5	2.7	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2C(N)=O)CC1	10.1016/j.ejmech.2020.112437
	228	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	33	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	6005	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	CHEMBL53	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	DB00714	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9911433
	156015087	176956	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	406	7	1	4	4.8	C=CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4640150	176956	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	406	7	1	4	4.8	C=CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	228	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	33	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	6005	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	CHEMBL53	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	DB00714	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm0108505
	228	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	33	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	6005	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	CHEMBL53	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	DB00714	441	26	None	-6	24	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(00)00655-7
	44424668	143828	0	None	-32	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	432	5	1	8	0.6	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL390581	143828	0	None	-32	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	432	5	1	8	0.6	Cn1c(=O)c2c([nH]c(=O)n2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	76336182	105016	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4ccccn4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121430	105016	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4ccccn4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	127051016	140332	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819642	140332	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819734	140332	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	46205046	124048	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
	CHEMBL3640587	124048	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
	46205046	124048	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
	CHEMBL3640587	124048	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)cc2OC2CNC2)c1	nan
	46203755	124013	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
	CHEMBL3640554	124013	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
	46205371	124052	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
	CHEMBL3640591	124052	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
	11617668	64350	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL181874	64350	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
	4806	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	7351	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	9966051	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	CHEMBL2104993	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	DB09068	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5-HT7R assessed as inhibition constantBinding affinity to human 5-HT7R assessed as inhibition constant	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2021.128275
	4806	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	7351	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	9966051	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	CHEMBL2104993	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	DB09068	3933	85	None	-8	13	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	11384575	65828	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	418	9	0	5	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(OC)cc1	10.1021/jm049743b
	CHEMBL184310	65828	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	418	9	0	5	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccc(OC)cc1	10.1021/jm049743b
	11373831	124116	0	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
	CHEMBL364124	124116	0	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1021/jm049743b
	46203755	124013	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
	CHEMBL3640554	124013	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2cccc(F)c2C)cc1OC1CNC1	nan
	46205371	124052	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
	CHEMBL3640591	124052	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	3	1	2	3.9	COc1ccc(-c2cccc(F)c2C)cc1C1CCNC1	nan
	11373831	124116	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1016/j.bmc.2011.09.044
	CHEMBL364124	124116	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	431	9	0	5	3.2	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc(C)cc1	10.1016/j.bmc.2011.09.044
	127026750	137139	0	None	14	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758591	137139	0	None	14	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2C2CCCC2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2015.11.040
	118626089	164910	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239823	164910	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626035	164955	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4240954	164955	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145983760	164977	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4241497	164977	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cccc2ncccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145983390	165355	0	None	-6	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1ccnc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4250274	165355	0	None	-6	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	535	6	0	7	5.0	O=S(=O)(c1ccnc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	134156305	153703	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3986254	153703	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	510	11	1	5	5.8	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)N[C@@H](C)c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	145993714	166787	0	None	21	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4294549	166787	0	None	21	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	127037681	136078	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	406	8	1	6	2.4	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cnn(C)c2)CC1	10.1039/C5MD00166H
	CHEMBL3739745	136078	0	None	7	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	406	8	1	6	2.4	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cnn(C)c2)CC1	10.1039/C5MD00166H
	127041106	136246	0	None	16	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	440	8	1	6	2.9	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1039/C5MD00166H
	CHEMBL3741281	136246	0	None	16	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	440	8	1	6	2.9	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1	10.1039/C5MD00166H
	117209858	183961	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	183961	1	None	-1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	66800934	111549	0	None	-8	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	9	1	7	4.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289949	111549	0	None	-8	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	9	1	7	4.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	118626089	164910	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239823	164910	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7R after 120 mins by scintillation counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	11101733	102346	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	413	5	1	3	4.9	Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL305526	102346	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	413	5	1	3	4.9	Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	10896196	202549	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	484	7	1	4	4.5	CN(C)C(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL71170	202549	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	484	7	1	4	4.5	CN(C)C(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	155555378	173852	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4553199	173852	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	10948529	53859	0	None	54	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	365	6	1	6	3.3	O=C(CCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL160706	53859	0	None	54	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	365	6	1	6	3.3	O=C(CCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	46205375	124056	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
	CHEMBL3640595	124056	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
	46205375	124056	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
	CHEMBL3640595	124056	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	4	1	3	4.3	COc1ccc(-c2ccccc2OC(F)(F)F)cc1C1CCNC1	nan
	162675490	182537	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	503	8	2	7	3.6	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4795056	182537	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	503	8	2	7	3.6	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc4c(c3)NC(=O)C(C)O4)CC2)cc1	10.1016/j.ejmech.2020.112395
	2470	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	3300	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	5265	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	99	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	CHEMBL267930	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/s0960-894x(00)00166-9
	10552788	18469	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm970519e
	CHEMBL12771	18469	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm970519e
	10552788	18469	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12771	18469	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	480	6	0	3	4.3	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1016/s0960-894x(00)00166-9
	44368304	44637	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	479	6	0	3	5.1	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm030841r
	CHEMBL152292	44637	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	479	6	0	3	5.1	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Br)c(Br)c2)CC1	10.1021/jm030841r
	134138168	147146	0	None	-1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147146	0	None	-1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5094493	213713	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	153287541	171619	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4473697	171619	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	135398737	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	38	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	722	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	CHEMBL42	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	DB00363	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	24865725	187491	0	None	-39	12	Human	7.7	pKi	=	7.7	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	CHEMBL497963	187491	0	None	-39	12	Human	7.7	pKi	=	7.7	Binding	Displacement of radioligand from human cloned 5HT7 receptorDisplacement of radioligand from human cloned 5HT7 receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	2470	3583	46	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	3300	3583	46	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	5265	3583	46	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	99	3583	46	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	CHEMBL267930	3583	46	None	-1258	60	Human	7.7	pKi	=	7.7	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030841r
	162668859	183150	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4788452	183150	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803670	183150	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	156020807	177464	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4647184	177464	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	127051016	140332	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819642	140332	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819734	140332	0	None	-6	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	386	5	1	4	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	6918542	203206	20	None	-537	11	Human	5.7	pKi	=	5.7	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	CHEMBL76237	203206	20	None	-537	11	Human	5.7	pKi	=	5.7	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	122483296	137564	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764934	137564	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765870	137564	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	164623281	185220	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	447	7	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4867109	185220	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	447	7	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	90656704	112175	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262435	112175	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304198	112175	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	381	10	1	4	4.6	CCN(CCCCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	122483296	137564	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764934	137564	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765870	137564	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	363	6	0	4	4.2	CN1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	71450247	82549	0	None	-380	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181188	82549	0	None	-380	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
	127026434	137202	0	None	3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	9	1	4	4.9	CC(C)c1cccc(C(C)C)c1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759170	137202	0	None	3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	9	1	4	4.9	CC(C)c1cccc(C(C)C)c1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	76314437	105014	0	None	25	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	443	5	0	3	6.6	c1ccc(-c2ccc(-n3cc(CN4CCN(c5ccccc5)CC4)c4ccccc43)cc2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121418	105014	0	None	25	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	443	5	0	3	6.6	c1ccc(-c2ccc(-n3cc(CN4CCN(c5ccccc5)CC4)c4ccccc43)cc2)cc1	10.1016/j.ejmech.2014.01.055
	155534362	171328	0	None	-91	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	522	8	1	6	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccccc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
	CHEMBL4469813	171328	0	None	-91	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	522	8	1	6	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccccc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
	168287508	190925	0	None	-48	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	438	9	3	8	3.1	Nc1nc(N)nc(NCCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5194270	190925	0	None	-48	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	438	9	3	8	3.1	Nc1nc(N)nc(NCCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	156020306	177545	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	602	11	0	6	6.9	O=S(=O)(c1ccccc1)N(CCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc(C(F)(F)F)c1	10.1016/j.bmc.2020.115459
	CHEMBL4648390	177545	0	None	-4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	602	11	0	6	6.9	O=S(=O)(c1ccccc1)N(CCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc(C(F)(F)F)c1	10.1016/j.bmc.2020.115459
	42625267	186215	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCCC(c2ccccc2)C1	10.1021/jm8014553
	CHEMBL489255	186215	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	348	6	0	2	4.2	O=C1Cc2ccccc2N1CCCCN1CCCC(c2ccccc2)C1	10.1021/jm8014553
	73213196	103968	1	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104093	103968	1	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	164622318	185244	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	CHEMBL4867534	185244	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	71455625	82537	0	None	-48977	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
	CHEMBL2181170	82537	0	None	-48977	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
	73213196	103968	1	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
	CHEMBL3104093	103968	1	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
	44517732	193551	0	None	4	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	8	3	5	2.9	COc1ccccc1N1CCN(C(=N)NCCCNS(=O)(=O)c2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL550881	193551	0	None	4	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	481	8	3	5	2.9	COc1ccccc1N1CCN(C(=N)NCCCNS(=O)(=O)c2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
	71727065	101923	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401931	101923	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
	CHEMBL3039720	101923	0	None	-8	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	5	0	6	4.3	COc1ccc2c(=O)c3cccc(CN4CCN(c5ccccc5OC)CC4)c3oc2c1	10.1016/j.bmcl.2013.05.062
	73213196	103968	1	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104093	103968	1	None	-1	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	51002362	82196	0	None	-3	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	448	5	1	7	3.8	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
	CHEMBL2179222	82196	0	None	-3	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	448	5	1	7	3.8	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)cnc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
	168273001	189608	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	403	9	4	7	3.3	COc1ccccc1CCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5174637	189608	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	403	9	4	7	3.3	COc1ccccc1CCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	72197845	89400	0	None	-25	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
	CHEMBL2377590	89400	0	None	-25	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2019.111736
	72197845	89400	0	None	-25	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
	CHEMBL2377590	89400	0	None	-25	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccccc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccc(F)cc23)CC1	10.1016/j.ejmech.2013.02.033
	127026143	137259	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	3	5.3	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759593	137259	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	3	5.3	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	155540198	172324	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	406	7	0	4	3.3	O=C(CCCCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4516076	172324	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	406	7	0	4	3.3	O=C(CCCCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	4790508	8076	5	None	-24	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	333	7	2	5	2.0	OC(CNCC1COc2ccccc2O1)COc1ccccc1F	10.1016/j.bmcl.2010.03.012
	CHEMBL1091933	8076	5	None	-24	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	333	7	2	5	2.0	OC(CNCC1COc2ccccc2O1)COc1ccccc1F	10.1016/j.bmcl.2010.03.012
	44424658	85322	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229180	85322	0	None	-2	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	23290944	81400	0	None	-131	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	CHEMBL2164350	81400	0	None	-131	7	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	45269494	194981	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	7	3	3	3.5	N=C(NCCCCNS(=O)(=O)c1cccc2ccccc12)N1CCc2ccccc2C1	10.1016/j.bmcl.2009.06.038
	CHEMBL564509	194981	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	7	3	3	3.5	N=C(NCCCCNS(=O)(=O)c1cccc2ccccc12)N1CCc2ccccc2C1	10.1016/j.bmcl.2009.06.038
	127026146	137236	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	449	7	2	3	5.7	O=C(Nc1cccc(Cl)c1)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759437	137236	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	449	7	2	3	5.7	O=C(Nc1cccc(Cl)c1)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2015.11.040
	156018383	177339	0	None	-16	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4645308	177339	0	None	-16	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2020.115459
	53381002	65119	0	None	-22	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
	CHEMBL1829959	65119	0	None	-22	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
	164620867	185050	0	None	-177	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4864448	185050	0	None	-177	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	410	6	1	7	3.4	CCCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	156018897	177228	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	356	4	1	3	3.6	CCCN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4643640	177228	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	356	4	1	3	3.6	CCCN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
	11397459	19146	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12908	19146	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	11259115	19191	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12933	19191	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
	11453756	19773	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL13032	19773	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	11382534	97641	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL273452	97641	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	49850567	56160	0	None	-999	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632217	56160	0	None	-999	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	11397459	19146	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	CHEMBL12908	19146	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	11259115	19191	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	CHEMBL12933	19191	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	11453756	19773	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	CHEMBL13032	19773	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	11382534	97641	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	CHEMBL273452	97641	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	350	6	0	2	4.9	CC(C)C1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	71602690	89243	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376459	89243	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
	153287567	171808	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
	CHEMBL4476396	171808	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
	155557042	173975	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
	CHEMBL4556297	173975	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
	153287557	175495	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4591108	175495	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	10296414	3462	11	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	76	3462	11	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	CHEMBL183460	3462	11	None	-158	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	73213195	103967	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104092	103967	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	164610456	183908	0	None	-61	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	328	5	1	7	1.7	CCC(Oc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4847379	183908	0	None	-61	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	328	5	1	7	1.7	CCC(Oc1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	9891618	106627	0	None	-1995	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	486	4	1	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
	CHEMBL316081	106627	0	None	-1995	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	486	4	1	6	5.0	Cc1c(S(=O)(=O)Nc2ccc3nccc(N4CCN(C)CC4)c3c2)sc2ccc(Cl)cc12	10.1016/s0960-894x(01)00558-3
	44393088	64667	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.ejmech.2019.111705
	CHEMBL182322	64667	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.ejmech.2019.111705
	44393113	63285	0	None	5	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	358	7	3	7	3.5	CC(Nc1nc(N)nc(NCCc2cccs2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL180086	63285	0	None	5	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	358	7	3	7	3.5	CC(Nc1nc(N)nc(NCCc2cccs2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	10475231	65041	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182937	65041	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	44393161	66348	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	334	8	2	5	4.1	C[C@H](Nc1ccnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL185511	66348	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	334	8	2	5	4.1	C[C@H](Nc1ccnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393045	161098	0	None	9	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	370	7	3	6	3.6	C[C@H](Nc1nc(N)nc(NCCc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL413049	161098	0	None	9	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	370	7	3	6	3.6	C[C@H](Nc1nc(N)nc(NCCc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	107	141	116	None	-3	31	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
	1833	141	116	None	-3	31	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
	CHEMBL8165	141	116	None	-3	31	Human	8.7	pKi	=	8.7	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1021/jm030030n
	145970078	164248	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	3	5.3	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.7b01898
	CHEMBL4218549	164248	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	485	7	1	3	5.3	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Cc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.7b01898
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030030n
	10028436	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
	3237	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
	CHEMBL95104	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1021/jm030030n
	1621	2386	16	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	17	2386	16	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	5761	2386	16	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	CHEMBL263881	2386	16	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	DB04829	2386	16	None	-34	45	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030030n
	127025242	137264	0	None	70	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759617	137264	0	None	70	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	446	8	1	4	4.3	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	71455002	81020	0	None	7	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159489	81020	0	None	7	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	155534839	171422	0	None	4	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccsc2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4471208	171422	0	None	4	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	437	6	1	3	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccsc2)c1	10.1016/j.bmcl.2019.126703
	56944954	157012	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	445	7	3	4	4.0	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4080399	157012	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	445	7	3	4	4.0	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	56944956	158361	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4095555	158361	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	10834268	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/j.bmc.2019.06.028
	CHEMBL428494	166262	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	390	6	1	4	3.6	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3	10.1016/j.bmc.2019.06.028
	10028436	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
	3237	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
	CHEMBL95104	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.bmcl.2018.06.019
	66800909	111565	0	None	4	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	8	3.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3289965	111565	0	None	4	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	8	3.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	10274894	164627	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	438	6	1	2	6.0	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL422869	164627	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	438	6	1	2	6.0	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	44266182	205583	0	None	23	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	407	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9347	205583	0	None	23	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	407	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2nnc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	24854368	159259	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	377	7	1	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL410628	159259	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	377	7	1	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00438-9
	5	139	66	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	5202	139	66	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	CHEMBL39	139	66	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	DB08839	139	66	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	11633354	95521	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	CHEMBL259550	95521	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	11633354	95521	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL259550	95521	0	None	52	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	5	139	66	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
	5202	139	66	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
	CHEMBL39	139	66	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
	DB08839	139	66	None	-3	55	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2016.06.080
	439280	119501	104	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
	6971044	119501	104	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
	CHEMBL350221	119501	104	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1016/j.bmcl.2015.02.042
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2019.111705
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/s0960-894x(02)00842-9
	10500557	16486	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2009.12.027
	CHEMBL12427	16486	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2009.12.027
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm0104264
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm980519u
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmc.2011.12.039
	44276598	95226	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2010.03.012
	CHEMBL25815	95226	0	None	1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/j.bmcl.2010.03.012
	9845006	18040	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm070279v
	CHEMBL12702	18040	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm070279v
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/acs.jmedchem.7b01898
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from recombinant human 5-HT7 receptor expressed in COS-7 cell membranes after 30 mins by liquid scintillation counting method	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2018.06.019
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.ejmech.2014.08.023
	141745657	171801	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	394	5	1	4	4.7	Fc1ccc2[nH]cc(CCCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
	CHEMBL4476294	171801	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	394	5	1	4	4.7	Fc1ccc2[nH]cc(CCCN3CCN(c4nsc5ccccc45)CC3)c2c1	10.1016/j.bmcl.2019.126703
	4106	2456	16	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
	5358812	2456	16	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
	89	2456	16	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
	CHEMBL93240	2456	16	None	-4	34	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.bmc.2019.07.046
	44437327	90422	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239231	90422	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	9888494	97706	0	None	1	13	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL273921	97706	0	None	1	13	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	9888494	97706	0	None	-1	13	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1021/jm0498102
	CHEMBL273921	97706	0	None	-1	13	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1021/jm0498102
	118706734	120002	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3310714	120002	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3545444	120002	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	145993474	166752	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4F)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4294077	166752	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	417	5	1	2	5.5	Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4F)CC3)c2c1	10.1016/j.ejmech.2017.12.063
	10862697	202671	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1cccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)c1	10.1021/jm0104264
	CHEMBL71847	202671	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1cccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)c1	10.1021/jm0104264
	44327688	112154	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL330353	112154	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/s0960-894x(02)00690-x
	44327688	112154	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1021/jm030030n
	CHEMBL330353	112154	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.4	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1	10.1021/jm030030n
	16006605	97530	3	None	2	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL272781	97530	3	None	2	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	135966709	154604	4	None	10	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	233	2	2	4	2.3	CNC1=Nc2c(OC(C)C)cccc2C(C)N1	10.1016/j.bmcl.2007.10.080
	CHEMBL402179	154604	4	None	10	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	233	2	2	4	2.3	CNC1=Nc2c(OC(C)C)cccc2C(C)N1	10.1016/j.bmcl.2007.10.080
	24825775	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	3929	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	CHEMBL4205349	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1016/j.ejmech.2019.111705
	24825775	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	3929	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	CHEMBL4205349	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.7b01898
	4376990	192397	4	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	192397	4	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	192397	4	None	1	11	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	24825775	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
	3929	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
	CHEMBL4205349	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assayBinding affinity to human 5-HT7 receptor expressed in HEK293F cells assessed as inhibition constant by HTRF assay	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1021/acs.jmedchem.2c00633
	CHEMBL5074190	212533	0	None	29	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	24825775	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	3929	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	CHEMBL4205349	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis	ChEMBL	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	10.1039/C8MD00313K
	16093485	154512	0	None	1	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	239	1	2	4	2.3	COc1cc(Cl)c(C)c2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	CHEMBL401745	154512	0	None	1	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	239	1	2	4	2.3	COc1cc(Cl)c(C)c2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	44266315	97920	0	None	30	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	410	5	0	3	4.3	O=C(c1ccc(Cl)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL275343	97920	0	None	30	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	410	5	0	3	4.3	O=C(c1ccc(Cl)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL5074190	212533	0	None	29	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	11153905	65260	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1016/j.bmc.2010.01.035
	CHEMBL183329	65260	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1016/j.bmc.2010.01.035
	24854369	95740	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3cccc(OC)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL260762	95740	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3cccc(OC)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	10064052	123737	0	None	93	6	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
	CHEMBL363466	123737	0	None	93	6	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
	10064052	123737	0	None	93	6	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
	CHEMBL363466	123737	0	None	93	6	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	311	4	0	3	3.8	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2	10.1021/jm0498102
	22001618	81387	6	None	1	3	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.ejmech.2019.111705
	CHEMBL2164336	81387	6	None	1	3	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.ejmech.2019.111705
	22001618	81387	6	None	-1	3	Rat	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 in rat brainBinding affinity to 5-HT7 in rat brain	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.bmc.2013.06.020
	CHEMBL2164336	81387	6	None	-1	3	Rat	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT7 in rat brainBinding affinity to 5-HT7 in rat brain	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1016/j.bmc.2013.06.020
	11545363	189894	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	379	7	1	4	3.7	COc1cccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)c1	10.1021/acs.jmedchem.2c00633
	CHEMBL5179267	189894	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor assessed as inhibition constant	ChEMBL	379	7	1	4	3.7	COc1cccc(N2CCN(CCCCC3C(=O)Nc4ccccc43)CC2)c1	10.1021/acs.jmedchem.2c00633
	168269899	189474	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5172635	189474	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	461	8	0	5	3.6	COc1ccccc1N1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccc(F)cc2)CC1	10.1021/acs.jmedchem.2c00633
	22001618	81387	6	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164336	81387	6	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	66801018	111587	0	None	2	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	502	8	1	7	4.4	Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3289986	111587	0	None	2	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	502	8	1	7	4.4	Cc1c(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	145991864	166441	0	None	5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2ccc(F)cc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4288120	166441	0	None	5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	449	6	1	2	6.0	Fc1cccc(-c2ccc(F)cc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.ejmech.2017.12.063
	153287566	170604	0	None	74	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4459009	170604	0	None	74	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
	23133427	81383	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164332	81383	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	256	2	1	2	2.9	Fc1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	118709756	113035	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321798	113035	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	352	6	0	2	4.4	O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	11772153	66524	0	None	3	3	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	CHEMBL186316	66524	0	None	3	3	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	44437335	151113	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396396	151113	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	44266222	206619	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	0	3	4.4	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9952	206619	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	387	4	0	3	4.4	O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL5077293	212710	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	162666034	181719	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4784228	181719	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL5077293	212710	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5094234	213787	0	None	2	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	213787	0	None	2	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11697659	95398	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	CHEMBL259010	95398	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	11697659	95398	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL259010	95398	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm070279v
	CHEMBL5091373	213781	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	213781	0	None	1	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	118713593	113867	0	None	26	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	338	5	0	4	3.9	O=c1sc2ccccc2n1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331262	113867	0	None	26	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	338	5	0	4	3.9	O=c1sc2ccccc2n1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
	90656683	110473	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262408	110473	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	118713684	113877	0	None	-6	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	425	9	0	6	4.5	COc1ccccc1N1CCN(CCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331387	113877	0	None	-6	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	425	9	0	6	4.5	COc1ccccc1N1CCN(CCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	11186985	123315	0	None	-11	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
	CHEMBL362540	123315	0	None	-11	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
	11267988	66480	0	None	-2	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
	CHEMBL186112	66480	0	None	-2	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
	10430685	53999	0	None	2	6	Rat	8.5	pKi	=	8.5	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL160817	53999	0	None	2	6	Rat	8.5	pKi	=	8.5	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	8	1	6	4.1	O=C(CCCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	118713682	113875	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	5	4.4	O=c1sc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331385	113875	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	5	4.4	O=c1sc2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	118728530	117210	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	454	9	0	7	4.5	CCOc1ccccc1N1CCN(CCCCCn2cnc3sc(C)c(C)c3c2=O)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401493	117210	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	454	9	0	7	4.5	CCOc1ccccc1N1CCN(CCCCCn2cnc3sc(C)c(C)c3c2=O)CC1	10.1016/j.bmcl.2015.02.042
	42388639	187461	0	None	-4	7	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL497749	187461	0	None	-4	7	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	5	3.3	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2009.06.038
	90656685	110472	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262407	110472	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	2470	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3583	46	None	-389	60	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards rat 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL5094493	213713	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	76336181	105905	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121425	105905	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139444	105905	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	433	4	1	4	5.8	Oc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	76318013	105906	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121427	105906	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139445	105906	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	435	4	0	3	6.0	FC(F)(F)c1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	127026452	137135	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	1	4	5.0	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758569	137135	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	1	4	5.0	O=S(=O)(NC1CC2CCC(C1)N2CCOc1cccc(-c2ccccc2)c1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2015.11.040
	127024949	137258	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	442	8	1	4	4.0	O=S(=O)(NC1CN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759581	137258	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	442	8	1	4	4.0	O=S(=O)(NC1CN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2015.11.040
	71454997	80985	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	9	1	5	5.1	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159455	80985	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	9	1	5	5.1	O=S(=O)(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	145947405	167099	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4159967	167099	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4301968	167099	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	472	7	2	6	2.3	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Cl)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	138691316	174106	0	None	61	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	289	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4559312	174106	0	None	61	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	289	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
	59752638	181805	0	None	-1	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4785470	181805	0	None	-1	4	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	11732538	202588	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1016/j.bmc.2019.06.028
	CHEMBL71390	202588	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1016/j.bmc.2019.06.028
	90656685	110472	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262407	110472	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	325	6	1	4	3.0	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	118713595	113869	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	4.1	O=c1sc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331264	113869	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	4.1	O=c1sc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	44439392	91336	0	None	4677	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	5	2	2	5.1	CCCSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241100	91336	0	None	4677	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	5	2	2	5.1	CCCSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	66801613	111545	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289945	111545	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	122178709	120848	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581254	120848	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	16573	177035	30	None	8	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL464099	177035	30	None	8	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	11341035	143798	0	None	1	2	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	CHEMBL390558	143798	0	None	1	2	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	42618265	182076	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	378	8	1	4	3.7	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL478905	182076	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	378	8	1	4	3.7	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	44266229	205974	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	364	5	0	3	3.6	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9564	205974	0	None	7	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	364	5	0	3	3.6	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
	14566720	101412	10	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	242	2	1	3	2.3	COc1ccc2cccc(N3CCNCC3)c2c1	10.1021/jm030826m
	CHEMBL300824	101412	10	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	242	2	1	3	2.3	COc1ccc2cccc(N3CCNCC3)c2c1	10.1021/jm030826m
	11732538	202588	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
	CHEMBL71390	202588	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccc(N2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
	11725453	98610	0	None	1	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
	CHEMBL28056	98610	0	None	1	6	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
	90656669	110487	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CCCN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262422	110487	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	8	1	4	3.8	CCCN(CCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	11725453	98610	0	None	-1	6	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL28056	98610	0	None	-1	6	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	11397459	19146	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL12908	19146	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	479	9	0	5	4.7	COc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	11259115	19191	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL12933	19191	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	435	7	0	4	4.3	O=S1(=O)c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2019.06.028
	11453756	19773	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL13032	19773	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	451	7	0	5	4.0	COc1ccccc1N1CCN(CCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	127040443	136173	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	382	9	1	4	3.2	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1039/C5MD00166H
	CHEMBL3740624	136173	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	382	9	1	4	3.2	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1039/C5MD00166H
	44439408	90770	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	426	4	0	5	4.9	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1C3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL240024	90770	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	426	4	0	5	4.9	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1C3)CC2	10.1016/j.bmcl.2007.01.093
	44439396	91365	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	348	3	0	3	4.3	CC(=O)OC1CCCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241281	91365	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	348	3	0	3	4.3	CC(=O)OC1CCCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	66800926	111586	0	None	6	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	7	1	7	4.0	Cc1c(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3289985	111586	0	None	6	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	488	7	1	7	4.0	Cc1c(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	2872937	117412	6	None	-2	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	464	4	1	5	4.7	O=S(=O)(Nc1cc2c(c3ccccc13)OC1(N3CCOCC3)CCCCC21)c1ccccc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403332	117412	6	None	-2	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	464	4	1	5	4.7	O=S(=O)(Nc1cc2c(c3ccccc13)OC1(N3CCOCC3)CCCCC21)c1ccccc1	10.1016/j.bmcl.2015.03.049
	127026145	137166	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	399	7	2	3	4.6	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758814	137166	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	399	7	2	3	4.6	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	156010319	176458	0	None	-3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4632519	176458	0	None	-3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115459
	145978420	163438	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc(I)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4208306	163438	0	None	2	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2cccc(I)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	155546190	175901	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4530770	175901	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4596654	175901	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	467	8	0	4	4.9	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	42626291	192101	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1c2ccccc2CN1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL521973	192101	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1c2ccccc2CN1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	71462154	80937	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	396	9	1	4	4.1	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159311	80937	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	396	9	1	4	4.1	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)C1	10.1016/j.ejmech.2012.07.043
	145977555	163079	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
	CHEMBL4204033	163079	0	None	10	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
	CHEMBL5092755	213602	0	None	-120	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1ccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)cc1C	10.1021/acs.jmedchem.1c00497
	5249591	168700	1	None	-257	2	Rat	5.7	pKi	=	5.7	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	419	4	0	5	3.4	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL441313	168700	1	None	-257	2	Rat	5.7	pKi	=	5.7	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	419	4	0	5	3.4	COc1ccccc1N1CCN([C@H]2CC[C@H](N3C(=O)c4ccccc4C3=O)CC2)CC1	10.1016/j.bmcl.2004.09.029
	135398745	2858	108	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
	47	2858	108	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
	CHEMBL715	2858	108	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
	DB00334	2858	108	None	-95	66	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.ejmech.2018.01.002
	155566191	175156	0	None	-67	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4583082	175156	0	None	-67	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	57390694	70107	0	None	-9	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	5	0	4	5.1	Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	CHEMBL1946255	70107	0	None	-9	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	5	0	4	5.1	Clc1ccc(N2CCCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	53323186	56703	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c(Cl)c1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644273	56703	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c(Cl)c1	10.1016/j.bmcl.2010.11.078
	155563452	174727	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4573441	174727	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	57396417	71188	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1949975	71188	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1963009	71188	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	484	5	0	5	4.1	O=S(=O)(c1ccc2cccnc2c1)N1CCC(CN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	44209472	69814	2	None	-114	11	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	CHEMBL1940420	69814	2	None	-114	11	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	134144304	153944	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3952251	153944	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3990525	153944	0	None	-2	9	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.4	O=C(CCCN1CCc2ccccc2CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	155563452	174727	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4573441	174727	0	None	-40	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	361	6	0	4	3.7	O=C(CCCN1CCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	752521	197050	7	None	-102	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	CHEMBL582877	197050	7	None	-102	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	145990093	166438	0	None	9	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	440	7	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4288077	166438	0	None	9	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	440	7	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	137649997	156735	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4076903	156735	0	None	3	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	464	6	0	5	3.8	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	145992305	166435	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	371	5	2	6	0.4	CC1(C)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4288040	166435	0	None	5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	371	5	2	6	0.4	CC1(C)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	46205369	124050	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
	CHEMBL3640589	124050	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
	46206019	124066	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640605	124066	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
	46205369	124050	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
	CHEMBL3640589	124050	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	3	1	2	4.0	Cc1ccc(-c2ccc(Cl)cc2OC2CNC2)cc1C	nan
	46206019	124066	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640605	124066	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1ccccc1-c1ccccc1C1CCNC1	nan
	155537074	171694	0	None	-147	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1cccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c12	10.1016/j.ejmech.2019.111857
	CHEMBL4474618	171694	0	None	-147	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1cccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c12	10.1016/j.ejmech.2019.111857
	46203751	124010	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
	CHEMBL3640551	124010	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
	44388858	61153	0	None	-2	4	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL177064	61153	0	None	-2	4	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against rat 5-HT7R expressed in HEK293 cellsBinding affinity against rat 5-HT7R expressed in HEK293 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
	44388858	61153	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL177064	61153	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.ejmech.2014.01.055
	76320704	103050	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1=CC=CC(C#N)[C@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
	CHEMBL3085300	103050	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1=CC=CC(C#N)[C@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
	2726	904	64	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	621	904	64	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	83	904	64	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	CHEMBL71	904	64	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	DB00477	904	64	None	-13	73	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030030n
	68788	205863	9	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	CHEMBL95067	205863	9	None	-1	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	348	3	2	3	1.3	CN1C[C@@H](NS(=O)(=O)N(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	46203751	124010	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
	CHEMBL3640551	124010	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)cc2C)cc1OC1CNC1	nan
	145975720	163397	0	None	2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	394	4	1	4	2.5	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4207835	163397	0	None	2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	394	4	1	4	2.5	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	134151118	151657	0	None	3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	498	12	1	4	5.4	CN(C)Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3968569	151657	0	None	3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	498	12	1	4	5.4	CN(C)Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	71453278	80998	0	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	7	1	3	4.5	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(F)c1F	10.1016/j.ejmech.2012.07.043
	CHEMBL2159467	80998	0	None	-1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	7	1	3	4.5	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccc(F)c1F	10.1016/j.ejmech.2012.07.043
	135398737	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	38	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	722	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	CHEMBL42	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	DB00363	942	89	None	-13	92	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2022.114193
	71574204	85826	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	CHEMBL2312640	85826	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	155557443	174062	0	None	9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	3	2.7	COc1ccc2[nH]cc(-c3cncn3C)c2c1F	10.1016/j.ejmech.2019.03.017
	CHEMBL4558202	174062	0	None	9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	3	2.7	COc1ccc2[nH]cc(-c3cncn3C)c2c1F	10.1016/j.ejmech.2019.03.017
	127037682	136057	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cncc3ccccc23)CC1	10.1039/C5MD00166H
	CHEMBL3739561	136057	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cncc3ccccc23)CC1	10.1039/C5MD00166H
	42618269	90542	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	397	6	0	4	3.1	O=C1CCCC(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239680	90542	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	397	6	0	4	3.1	O=C1CCCC(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	24854109	160727	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	397	6	1	3	4.5	CCC1(CCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL412143	160727	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	397	6	1	3	4.5	CCC1(CCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	136180317	117195	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401479	117195	0	None	-7	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	4	3.7	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL5082182	213011	1	None	-4	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(Cl)c1	10.1021/acs.jmedchem.1c00497
	44324403	205148	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	265	2	2	3	3.3	Cc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL90752	205148	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	265	2	2	3	3.3	Cc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	11811833	102582	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	418	7	1	3	5.0	COC1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL307352	102582	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	418	7	1	3	5.0	COC1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL5077755	212732	0	None	-12	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(Cl)c(Cl)c1	10.1021/acs.jmedchem.1c00497
	57401515	68041	0	None	-32	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	498	8	0	5	4.0	COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL1916745	68041	0	None	-32	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	498	8	0	5	4.0	COc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	44582676	189177	0	None	-64	18	Human	6.7	pKi	=	6.7	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL516088	189177	0	None	-64	18	Human	6.7	pKi	=	6.7	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	11373934	84242	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	CHEMBL222507	84242	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	60165537	74986	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	308	5	0	3	4.6	c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
	CHEMBL2037523	74986	0	None	-1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	308	5	0	3	4.6	c1ccc2c(c1)CN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
	73213195	103967	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104092	103967	0	None	-7	12	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	22065997	98883	0	None	-64	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
	CHEMBL282424	98883	0	None	-64	4	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccccc1N1CCN(Cc2c[nH]c3ncccc23)CC1	10.1016/s0960-894x(01)00241-4
	145964694	163474	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4208791	163474	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	450	9	2	5	3.1	CC(C)c1ccccc1OCC(O)CN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	145947301	167092	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4160262	167092	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4301925	167092	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3F)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	145976787	163063	0	None	20	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2ccccc2C(F)(F)F)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4203823	163063	0	None	20	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	428	7	1	4	3.5	O=S(=O)(NC1CCN(CCOc2ccccc2C(F)(F)F)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	118728529	117209	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401492	117209	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4ccc(Cl)cc4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	155564110	174787	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4574793	174787	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	122483297	137550	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763670	137550	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765839	137550	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	155564110	174787	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4574793	174787	0	None	-23	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	375	6	0	4	4.0	O=C(CCCN1CCCN(c2ccc(Cl)cn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	22330705	117426	6	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	438	3	0	3	5.5	Cc1ccc(Cl)cc1N(C)C(=O)c1cn(-c2ccc(F)cc2F)c(=O)c2ccccc12	10.1016/j.bmcl.2015.03.049
	CHEMBL3403345	117426	6	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	438	3	0	3	5.5	Cc1ccc(Cl)cc1N(C)C(=O)c1cn(-c2ccc(F)cc2F)c(=O)c2ccccc12	10.1016/j.bmcl.2015.03.049
	25107650	186692	0	None	-23	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	CHEMBL492872	186692	0	None	-23	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	122483297	137550	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763670	137550	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765839	137550	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	320	5	0	3	4.7	O=C(CCCCN1CCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	155569568	175610	0	None	-32	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	380	7	2	3	5.4	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(Cl)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4593671	175610	0	None	-32	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	380	7	2	3	5.4	COc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(Cl)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	145990459	166398	0	None	2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	490	7	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4287320	166398	0	None	2	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	490	7	2	5	2.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(Cc3cccc4ccccc34)CC2)C1=O	10.1039/C8MD00168E
	71602689	89242	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376458	89242	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
	162669595	182152	0	None	-24	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
	CHEMBL4790020	182152	0	None	-24	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	489	7	1	6	5.0	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(Cl)cc12	10.1016/j.ejmech.2020.112149
	71602689	89242	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376458	89242	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2013.02.038
	71456780	80993	0	None	-7	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	4	3.5	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159462	80993	0	None	-7	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	426	8	1	4	3.5	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccc(Cl)c1	10.1016/j.ejmech.2012.07.043
	44374225	54446	0	None	54	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	244	4	0	4	3.1	CN(C)CCSc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2003.11.050
	CHEMBL161203	54446	0	None	54	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	244	4	0	4	3.1	CN(C)CCSc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2003.11.050
	90654687	109606	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	475	8	1	6	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235759	109606	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	475	8	1	6	2.9	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	145986031	165258	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4248544	165258	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	118731361	117681	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	558	10	0	4	5.8	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409044	117681	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	558	10	0	4	5.8	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	139488527	168955	0	None	42	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	272	3	2	3	2.3	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4435235	168955	0	None	42	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	272	3	2	3	2.3	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)c(F)c12	10.1016/j.ejmech.2019.03.017
	56660668	176516	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)C1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
	CHEMBL4633326	176516	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)C1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
	155561978	175243	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	518	8	1	6	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4584900	175243	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	518	8	1	6	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	42625445	186186	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL489028	186186	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.08.023
	21963826	76383	5	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	398	7	0	4	4.0	O=S(=O)(c1ccccc1)C1(CCCN2CCN(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206747	76383	5	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	398	7	0	4	4.0	O=S(=O)(c1ccccc1)C1(CCCN2CCN(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
	118711997	113570	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1cccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2014.07.026
	CHEMBL3326986	113570	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1cccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2014.07.026
	122178707	120846	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581252	120846	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	25107649	186664	0	None	-1	3	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	CHEMBL492691	186664	0	None	-1	3	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	142601333	185171	0	None	36	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185171	0	None	36	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127051592	140334	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818710	140334	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819742	140334	0	None	1	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	44340897	9604	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	4	2.9	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)NCC3)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL113192	9604	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	4	2.9	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)NCC3)CC1	10.1016/s0960-894x(02)00690-x
	164609650	184404	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4854456	184404	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	164611932	184609	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4857597	184609	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	127051592	140334	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818710	140334	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819742	140334	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	71602690	89243	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376459	89243	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2013.02.038
	53323185	56698	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	288	3	1	2	3.8	c1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644268	56698	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	288	3	1	2	3.8	c1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
	44439397	90767	0	None	22	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	4	0	5	4.7	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)N(C(=O)OC(C)(C)C)CC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL240021	90767	0	None	22	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	4	0	5	4.7	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)N(C(=O)OC(C)(C)C)CC3)CC2	10.1016/j.bmcl.2007.01.093
	11453751	90515	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	451	3	0	4	4.3	CC1(C)CC(=O)N(C2CCC(N3CCN(c4cccc(C(F)(F)F)c4)CC3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
	CHEMBL239467	90515	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	451	3	0	4	4.3	CC1(C)CC(=O)N(C2CCC(N3CCN(c4cccc(C(F)(F)F)c4)CC3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
	13069655	120082	0	None	-18	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3360992	120082	0	None	-18	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3546106	120082	0	None	-18	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	412	6	0	9	0.7	COc1ccccc1N1CCN(CCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	164608999	183792	0	None	-18	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4845741	183792	0	None	-18	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	71451454	80986	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	8	1	5	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159456	80986	0	None	-2	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	398	8	1	5	3.0	O=S(=O)(NCC1CCN(CCOc2cccc(F)c2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	71460456	80944	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	382	6	1	3	3.6	O=C(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159318	80944	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	382	6	1	3	3.6	O=C(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	127028152	137664	0	None	12	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	426	6	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3769836	137664	0	None	12	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	426	6	2	5	1.8	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	90654681	109600	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	454	7	1	4	3.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235753	109600	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	454	7	1	4	3.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.03.005
	11133795	202069	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	2	3	3.9	NC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL68094	202069	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	2	3	3.9	NC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	117209864	185442	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	185442	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	164617626	184868	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4861794	184868	0	None	-9	7	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	57402588	68069	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917347	68069	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	145992567	166212	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	548	8	2	5	4.4	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4283960	166212	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	548	8	2	5	4.4	CC1(c2cccc3ccccc23)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	25107519	187076	0	None	-17	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	CHEMBL495120	187076	0	None	-17	3	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	10.1021/jm800615e
	46233349	198605	5	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	244	4	0	3	1.8	CN(C)CCOc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	CHEMBL597356	198605	5	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	244	4	0	3	1.8	CN(C)CCOc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	129103318	166749	0	None	-309	15	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	CHEMBL4293999	166749	0	None	-309	15	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat cerebral cortex homogenates after 30 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	117209864	185442	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	185442	1	None	1	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	90656698	112098	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262431	112098	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3302234	112098	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	366	9	1	3	5.3	CN(CCCCCCN1CCC(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	43840296	149759	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	227	4	1	2	3.1	CNCc1cccc(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3952849	149759	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	227	4	1	2	3.1	CNCc1cccc(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	3303	2204	41	None	-331	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
	5311200	2204	41	None	-331	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
	CHEMBL267014	2204	41	None	-331	15	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00241-4
	46205045	124047	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640586	124047	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	46205045	124047	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640586	124047	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	392	6	1	3	4.2	CCN(CC)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	57395598	68068	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917346	68068	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	145976722	163426	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
	CHEMBL4208165	163426	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1Br	10.1021/acs.jmedchem.8b00828
	136180319	117197	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	1	4	3.5	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	CHEMBL3401481	117197	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	1	4	3.5	O=c1[nH]c(CCCCCN2CCN(c3ccccc3)CC2)nc2ccccc12	10.1016/j.bmcl.2015.02.042
	60165418	74984	0	None	-281	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037521	74984	0	None	-281	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.ejmech.2012.03.042
	851853	190714	13	None	-3	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	239	1	1	2	1.5	NC(=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	CHEMBL5191370	190714	13	None	-3	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	239	1	1	2	1.5	NC(=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	53320865	56712	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccccc1Cn1cc(-c2ccccc2)c2c1CCNC2	10.1016/j.bmcl.2010.11.078
	CHEMBL1644484	56712	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccccc1Cn1cc(-c2ccccc2)c2c1CCNC2	10.1016/j.bmcl.2010.11.078
	11341394	84235	0	None	2	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	2	4	3.7	NC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222489	84235	0	None	2	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	448	9	2	4	3.7	NC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	168290928	191250	0	None	-10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.3	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(C(F)(F)F)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5199182	191250	0	None	-10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.3	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(C(F)(F)F)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	162650168	179516	0	None	-389	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4748379	179516	0	None	-389	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
	162651619	179721	0	None	-288	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4751063	179721	0	None	-288	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	475	7	1	6	4.7	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(Cl)cc2s1	10.1016/j.ejmech.2020.112149
	44393052	64927	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	378	9	2	7	3.6	C[C@H](Nc1nc(NCCOc2ccccc2)nc(N(C)C)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182840	64927	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	378	9	2	7	3.6	C[C@H](Nc1nc(NCCOc2ccccc2)nc(N(C)C)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	58405183	110195	0	None	-4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
	CHEMBL3260336	110195	0	None	-4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
	209	2996	94	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	2113	2996	94	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	4748	2996	94	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	CHEMBL567	2996	94	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	DB00850	2996	94	None	-31	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1021/jm030030n
	44460725	105148	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	325	3	0	3	3.3	CN1CCCN(CCn2ccc3ccc(C(F)(F)F)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL312489	105148	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	325	3	0	3	3.3	CN1CCCN(CCn2ccc3ccc(C(F)(F)F)cc32)CC1	10.1016/s0960-894x(02)00438-9
	118626045	165105	0	None	-4	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4244691	165105	0	None	-4	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145947359	167083	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4171652	167083	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4301757	167083	0	None	9	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	463	7	2	7	1.5	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4C#N)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	60196074	81390	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2ccccc2N2CCNCC2)nc1	10.1021/jm3003679
	CHEMBL2164340	81390	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2ccccc2N2CCNCC2)nc1	10.1021/jm3003679
	155537788	171775	0	None	16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	436	6	1	6	4.4	O=c1[nH]c(SCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4475894	171775	0	None	16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	436	6	1	6	4.4	O=c1[nH]c(SCCCN2CCN(c3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	117209965	184655	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	184655	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601333	185171	0	None	36	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185171	0	None	36	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	164609650	184404	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4854456	184404	0	None	1	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	389	4	0	4	4.0	O=C1c2cc(Cl)c(Cl)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	10593348	96833	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL26907	96833	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	134134210	143241	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	255	4	0	2	3.7	COc1ccccc1-c1cc(CN(C)C)ccc1C	10.1016/j.ejmech.2016.07.029
	CHEMBL3901042	143241	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	255	4	0	2	3.7	COc1ccccc1-c1cc(CN(C)C)ccc1C	10.1016/j.ejmech.2016.07.029
	68281136	111550	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	422	7	1	7	2.8	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289950	111550	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	422	7	1	7	2.8	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	122178710	120849	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581255	120849	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	135458410	166625	0	None	-4	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL429136	166625	0	None	-4	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	117209965	184655	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	184655	1	None	3	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	153287542	168956	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4435237	168956	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	109026957	171260	2	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	394	6	0	6	1.3	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4468683	171260	2	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	394	6	0	6	1.3	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2016.06.080
	132547276	141616	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	11	0	6	4.9	CCOc1ccccc1N1CCN(CCCCCOc2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3883640	141616	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	11	0	6	4.9	CCOc1ccccc1N1CCN(CCCCCOc2cc(-c3ccccc3)ncn2)CC1	10.1016/j.bmc.2016.12.039
	71061756	92673	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442997	92673	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71061756	92673	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442997	92673	0	None	38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccccn3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	162666163	181789	0	None	22	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	10	0	6	6.7	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4785158	181789	0	None	22	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	10	0	6	6.7	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	11825129	48493	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
	CHEMBL155861	48493	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
	71061659	92674	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL2442998	92674	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	71061659	92674	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	CHEMBL2442998	92674	0	None	53	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7A receptor expressed in HEK293 cells after 60 mins	ChEMBL	474	11	1	6	3.6	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3cccnc3)CC2)cc1	10.1016/j.bmcl.2013.09.025
	11059148	202206	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	434	7	1	5	4.1	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)CCC3	10.1021/jm0104264
	CHEMBL69040	202206	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	434	7	1	5	4.1	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)CCC3	10.1021/jm0104264
	118736365	118419	0	None	-32	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	7	1	10	1.4	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423329	118419	0	None	-32	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	7	1	10	1.4	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	2232766	160812	7	None	-42	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	297	7	0	2	4.9	c1ccc2c(OCCCCCN3CCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	CHEMBL4126145	160812	7	None	-42	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	297	7	0	2	4.9	c1ccc2c(OCCCCCN3CCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	155561581	175057	0	None	-9	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	6	-0.3	CN1CCN(c2nc(N)nc(C[Se]c3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4580959	175057	0	None	-9	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	6	-0.3	CN1CCN(c2nc(N)nc(C[Se]c3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	122483222	137566	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764889	137566	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765872	137566	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	127028154	137716	0	None	7	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770473	137716	0	None	7	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	168295269	191904	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
	CHEMBL5209272	191904	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
	162653993	183076	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4753809	183076	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4802865	183076	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	122483222	137566	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764889	137566	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765872	137566	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	391	6	0	4	4.2	CC(=O)N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	57390336	68062	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	10	1	4	2.9	NCCCN(CCCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917340	68062	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	10	1	4	2.9	NCCCN(CCCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	155514378	169272	0	None	-588	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cccc2ncccc12	10.1021/acsmedchemlett.6b00056
	CHEMBL4440130	169272	0	None	-588	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cccc2ncccc12	10.1021/acsmedchemlett.6b00056
	155559092	174207	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4561846	174207	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	71451456	80994	0	None	-31	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	3.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159463	80994	0	None	-31	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	3.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(F)c2)CC1	10.1016/j.ejmech.2012.07.043
	59757163	105848	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092760	105848	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139189	105848	0	None	-218	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	145985289	165143	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cncc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4245607	165143	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	534	6	0	6	5.6	O=S(=O)(c1cncc2ccccc12)N1CCCCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	127037680	136357	0	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	442	8	1	5	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1039/C5MD00166H
	CHEMBL3742257	136357	0	None	19	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	442	8	1	5	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)CC1	10.1039/C5MD00166H
	66801429	159168	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	6	2	3	4.5	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4104596	159168	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	6	2	3	4.5	Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	44408813	74658	0	None	29	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
	CHEMBL203400	74658	0	None	29	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
	118709740	113020	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	348	7	0	2	4.2	O=C1Cc2ccccc2N1CCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321778	113020	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	348	7	0	2	4.2	O=C1Cc2ccccc2N1CCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	122178700	120778	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3580670	120778	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	122178705	120844	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581250	120844	0	None	-2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	11384146	200038	0	None	-60	9	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12	10.1021/jm049243i
	CHEMBL606556	200038	0	None	-60	9	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12	10.1021/jm049243i
	155566508	175221	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.6	COc1ccccc1N1CCN(C(=O)CCN2CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4584464	175221	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.6	COc1ccccc1N1CCN(C(=O)CCN2CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	164611932	184609	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4857597	184609	0	None	-5	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	364	6	1	4	3.1	O=C1CCc2cc(CCCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	9996500	18170	1	None	-10	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	326	6	0	4	3.1	COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1	10.1021/acs.jmedchem.7b01898
	CHEMBL1271151	18170	1	None	-10	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	326	6	0	4	3.1	COc1cccc(CCN2CCN(c3ccccc3OC)CC2)c1	10.1021/acs.jmedchem.7b01898
	136152964	193260	0	None	-8	8	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL541993	193260	0	None	-8	8	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	C[C@@H]1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	118524964	177551	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	243	2	0	1	3.8	CN(C)C1CCc2c(cccc2C2CCCC2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4648489	177551	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	243	2	0	1	3.8	CN(C)C1CCc2c(cccc2C2CCCC2)C1	10.1016/j.bmc.2019.115262
	66801561	155524	0	None	-794	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4062817	155524	0	None	-794	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	9856041	23895	2	None	-79432	9	Human	4.6	pKi	=	4.6	Binding	Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL133868	23895	2	None	-79432	9	Human	4.6	pKi	=	4.6	Binding	Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandInhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	60165545	74990	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	336	6	0	4	4.7	O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037527	74990	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	336	6	0	4	4.7	O=C(CCCCN1Cc2ccccc2C1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	90656707	110491	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	400	7	1	3	5.3	CN(CCCN1CCC(c2ccccc2)(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262426	110491	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	400	7	1	3	5.3	CN(CCCN1CCC(c2ccccc2)(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	168292233	191254	0	None	-34	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	4.2	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5199228	191254	0	None	-34	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	8	0	6	4.2	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	1346	83	108	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
	280	83	108	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
	9899402	83	108	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
	CHEMBL9666	83	108	None	-147	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	10.1021/jm3003679
	42618263	181897	0	None	-9	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	336	5	1	4	2.5	O=c1[nH]c2ccccc2n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL478682	181897	0	None	-9	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	336	5	1	4	2.5	O=c1[nH]c2ccccc2n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	155534184	171366	0	None	-162	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccccc2F)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	CHEMBL4470437	171366	0	None	-162	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	514	7	1	5	5.3	O=c1c(-c2ccccc2F)c2n(c(=O)n1CCCCN1CCCC(c3c[nH]c4ccccc34)C1)CCCC2	10.1016/j.ejmech.2019.07.027
	71457690	83370	0	None	-2	5	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205817	83370	0	None	-2	5	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
	145965668	163551	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3Cl)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4209807	163551	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3Cl)CC1)C2	10.1016/j.bmcl.2018.06.019
	162650396	179495	0	None	-12	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4748107	179495	0	None	-12	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	469	7	1	5	4.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2cc(Cl)ccc2c1	10.1016/j.ejmech.2020.112149
	155542237	172510	0	None	-117	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	472	7	2	6	5.2	COc1ccc2c(c1)c(-c1[nH]c(NCc3ccccc3)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4520003	172510	0	None	-117	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	472	7	2	6	5.2	COc1ccc2c(c1)c(-c1[nH]c(NCc3ccccc3)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	155514576	175966	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
	CHEMBL4441060	175966	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
	CHEMBL4597227	175966	0	None	-245	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	338	3	2	5	2.9	Nc1ncc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)[nH]1	10.1016/j.ejmech.2019.06.001
	60165543	74982	0	None	-47	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	367	6	0	7	2.9	O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037519	74982	0	None	-47	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	367	6	0	7	2.9	O=C(CCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	4407909	192254	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192254	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192254	1	None	-4	10	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	58404615	124023	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
	CHEMBL3640563	124023	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
	58404615	124023	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
	CHEMBL3640563	124023	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2ccc(C)c(C)c2)cc1OC1CNC1	nan
	CHEMBL5084249	213123	0	None	-3	8	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	134144864	150143	0	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	600	15	1	7	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3955917	150143	0	None	6	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	600	15	1	7	5.1	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(OCCN4CCOCC4)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	155540807	171939	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccccc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL4483554	171939	0	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccccc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
	2756712	81382	77	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	CHEMBL2164331	81382	77	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	238	2	1	2	2.8	c1ccc(-c2cccc(N3CCNCC3)c2)cc1	10.1021/jm3003679
	135398737	942	89	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	38	942	89	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	722	942	89	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	CHEMBL42	942	89	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	DB00363	942	89	None	-13	92	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2014.01.065
	155517162	169563	0	None	-16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	432	6	1	2	6.4	Fc1ccc(OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126769
	CHEMBL4444213	169563	0	None	-16	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	432	6	1	2	6.4	Fc1ccc(OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126769
	134154069	153898	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3970299	153898	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3990113	153898	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	57395086	71194	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
	CHEMBL1949966	71194	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
	CHEMBL1963029	71194	0	None	2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2cccnc12	10.1016/j.bmc.2011.12.039
	2220	3073	78	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	27400	3073	78	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	93	3073	78	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	CHEMBL294951	3073	78	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	DB06153	3073	78	None	-3	14	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	11582132	65665	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	CHEMBL1836860	65665	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	66800823	111561	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	7	1	7	4.4	Cc1c(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3289961	111561	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	7	1	7	4.4	Cc1c(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	23661594	90180	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL238808	90180	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	162670445	182282	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CCC(C)(C)CCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4791805	182282	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CCC(C)(C)CCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	44266267	206049	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	5	0	3	4.8	O=C1c2ccccc2CCCC1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9615	206049	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	363	5	0	3	4.8	O=C1c2ccccc2CCCC1CCN1CCC(Oc2ccccc2)CC1	10.1016/s0960-894x(03)00077-5
	49850672	56077	0	None	-100	9	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1631532	56077	0	None	-100	9	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	11729084	202486	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	0	2	5.2	CN1C(=O)C2(CCCCN3CC=C(c4ccccc4)CC3)CCCc3cccc1c32	10.1021/jm0104264
	CHEMBL70819	202486	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	0	2	5.2	CN1C(=O)C2(CCCCN3CC=C(c4ccccc4)CC3)CCCc3cccc1c32	10.1021/jm0104264
	10593348	96833	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	CHEMBL26907	96833	0	None	4	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	CHEMBL5084249	213123	0	None	-3	8	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	117209962	184276	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184276	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	134154069	153898	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3970299	153898	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3990113	153898	0	None	-1	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1ccc2sc(CCCCN3CCc4ccccc4C3)nc2c1	10.1016/j.bmc.2016.09.019
	162654406	179988	0	None	-63	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4754193	179988	0	None	-63	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
	179	396	107	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	2159	396	107	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	963	396	107	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	CHEMBL243712	396	107	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	DB06288	396	107	None	-9	51	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	168293874	191571	0	None	-5	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	191571	0	None	-5	11	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	24854186	95324	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccc(OC)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL258593	95324	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccc(OC)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	24768520	92561	0	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL244161	92561	0	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	46204422	124029	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640569	124029	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
	46204422	124029	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640569	124029	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	3.7	FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1	nan
	134134456	142800	0	None	20	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	514	11	1	5	5.4	COc1ccc(-c2cc(F)ccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3897426	142800	0	None	20	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	514	11	1	5	5.4	COc1ccc(-c2cc(F)ccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	44341130	9542	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	5	2.2	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]nnc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL112765	9542	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	377	5	1	5	2.2	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]nnc3c2)CC1	10.1016/s0960-894x(02)00690-x
	162674732	182793	0	None	48	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	9	1	7	5.2	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4797980	182793	0	None	48	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	9	1	7	5.2	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	162651486	179679	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4750587	179679	0	None	-3	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	437	7	1	5	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1	10.1016/j.ejmech.2020.112149
	10805599	98746	0	None	-13	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL281554	98746	0	None	-13	3	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	72550865	113568	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326984	113568	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.07.026
	53318219	56717	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	350	4	0	2	5.2	CCN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644489	56717	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	350	4	0	2	5.2	CCN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	42625356	186406	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C\CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	CHEMBL490644	186406	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C\CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	66801267	111580	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3289979	111580	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	7	1	6	4.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	42618259	189132	0	None	-13	2	Human	5.6	pKi	=	5.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	442	6	0	6	3.9	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
	CHEMBL515783	189132	0	None	-13	2	Human	5.6	pKi	=	5.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	442	6	0	6	3.9	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
	44439401	91337	0	None	-12	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	4	0	5	3.6	COC(=O)N1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241101	91337	0	None	-12	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	395	4	0	5	3.6	COC(=O)N1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	11294248	167165	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL430280	167165	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmc.2019.06.028
	44401243	167918	0	None	-104	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL435301	167918	0	None	-104	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	11294248	167165	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL430280	167165	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/s0960-894x(00)00166-9
	11294248	167165	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	CHEMBL430280	167165	0	None	-1	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	465	8	0	5	4.4	COc1ccccc1N1CCN(CCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1021/jm030841r
	168283304	190681	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	433	6	0	7	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5190746	190681	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	433	6	0	7	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	142601323	185249	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185249	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	122483235	137560	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763329	137560	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765849	137560	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	9890119	206307	0	None	-2511	7	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	452	4	2	5	4.3	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1	10.1016/s0960-894x(01)00558-3
	CHEMBL97596	206307	0	None	-2511	7	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligandBinding affinity to human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]-5-CT as radioligand	ChEMBL	452	4	2	5	4.3	O=S(=O)(Nc1ccc2nccc(N3CCNCC3)c2c1)c1ccc2c(Cl)cccc2c1	10.1016/s0960-894x(01)00558-3
	6918647	100265	2	None	-501	14	Human	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
	CHEMBL292759	100265	2	None	-501	14	Human	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
	155534795	175667	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4471055	175667	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4594879	175667	0	None	-316	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	402	3	2	5	4.3	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2019.06.001
	155534575	171370	0	None	-12	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	429	8	0	7	2.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4470487	171370	0	None	-12	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	429	8	0	7	2.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
	142601323	185249	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185249	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	122483235	137560	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763329	137560	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765849	137560	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	438	8	0	3	7.0	O=C(CCCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	90656675	110471	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	297	5	2	4	2.6	Oc1cccc(NCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262404	110471	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	297	5	2	4	2.6	Oc1cccc(NCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	44437333	91308	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	791	25	0	8	9.8	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL240944	91308	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	791	25	0	8	9.8	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	1296368	50534	16	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	458	5	2	5	6.0	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1	10.1016/j.bmcl.2015.03.049
	CHEMBL1576791	50534	16	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	458	5	2	5	6.0	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccccc1	10.1016/j.bmcl.2015.03.049
	134152583	152631	0	None	10	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2cccnc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3976948	152631	0	None	10	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2cccnc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	162670926	183161	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4790694	183161	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803789	183161	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.7	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	18133518	164148	1	None	14	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccc(Cl)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4217334	164148	1	None	14	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccc(Cl)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	168284840	190692	0	None	-8	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	439	5	0	6	3.8	O=c1n(CC2CCC(CN3CCN(c4cccc(Cl)c4)CC3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5190996	190692	0	None	-8	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	439	5	0	6	3.8	O=c1n(CC2CCC(CN3CCN(c4cccc(Cl)c4)CC3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	134141355	154036	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3924565	154036	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3991357	154036	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	134141355	154036	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3924565	154036	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3991357	154036	0	None	-2	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	327	5	0	2	4.8	O=C(CCCN1CCCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.09.019
	44324603	110972	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	252	2	2	4	2.4	Cc1c(NC2=NCCN2)cccc1-c1cccnc1	10.1016/s0960-894x(02)00925-3
	CHEMBL327654	110972	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	252	2	2	4	2.4	Cc1c(NC2=NCCN2)cccc1-c1cccnc1	10.1016/s0960-894x(02)00925-3
	145965401	163483	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1I	10.1021/acs.jmedchem.8b00828
	CHEMBL4208911	163483	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1I	10.1021/acs.jmedchem.8b00828
	44437332	91140	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL240729	91140	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	134142259	145040	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	2	5	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCO)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3915374	145040	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	2	5	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCO)cc1	10.1016/j.ejmech.2016.05.005
	127027387	137304	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	8	2	5	3.8	Nc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759948	137304	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	451	8	2	5	3.8	Nc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2015.11.040
	242	467	117	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	34	467	117	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	60795	467	117	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	CHEMBL1112	467	117	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	DB01238	467	117	None	-15	52	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2012.11.042
	25125376	177392	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2cccc(Cl)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4646015	177392	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2cccc(Cl)c2)C1	10.1016/j.bmc.2019.115262
	4806	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	4806	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	7351	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	7351	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	9966051	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	9966051	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	CHEMBL2104993	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	CHEMBL2104993	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	DB09068	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126703
	DB09068	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2019.126769
	54598063	154008	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL3979261	154008	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL3991129	154008	0	None	-37	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor after 60 mins by liquid scintillation counting method	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2c(C)cccc2C)CC1	10.1016/j.bmcl.2018.04.059
	4806	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	7351	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	9966051	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	CHEMBL2104993	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	DB09068	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.bmcl.2017.11.007
	21048761	139763	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	7	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL380613	139763	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	397	7	0	3	5.0	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)CC2)CCC1	10.1016/j.bmcl.2005.11.067
	424430	107130	3	None	60	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	3	2	2	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL319005	107130	3	None	60	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	3	2	2	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	46233352	198962	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	248	5	0	4	3.0	CN(C)CCSc1cccc(-c2ccoc2)n1	10.1016/j.bmc.2010.01.035
	CHEMBL599612	198962	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	248	5	0	4	3.0	CN(C)CCSc1cccc(-c2ccoc2)n1	10.1016/j.bmc.2010.01.035
	4806	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	7351	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	9966051	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	CHEMBL2104993	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	DB09068	3933	85	None	-8	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1016/j.ejmech.2017.12.063
	23369421	180885	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	380	7	1	5	2.9	COc1ccccc1N1CCN(CCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL476463	180885	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	380	7	1	5	2.9	COc1ccccc1N1CCN(CCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	71061750	104522	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3ncccc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113603	104522	0	None	23	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3ncccc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	72548115	113573	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326989	113573	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2014.07.026
	109027017	173818	2	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	378	5	0	4	2.5	O=C(CCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4552394	173818	2	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	378	5	0	4	2.5	O=C(CCN1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL5080305	212895	0	None	-4	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1cccc(S(=O)(=O)CC2CCN(CCCc3noc4cc(F)ccc34)C2)c1	10.1021/acs.jmedchem.1c00497
	44324573	111028	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	285	2	2	3	3.7	Cc1c(NC2=NCCN2)cccc1-c1cccc(Cl)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL327906	111028	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	285	2	2	3	3.7	Cc1c(NC2=NCCN2)cccc1-c1cccc(Cl)c1	10.1016/s0960-894x(02)00925-3
	10521887	113858	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	351	6	0	5	3.2	O=c1oc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331254	113858	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	351	6	0	5	3.2	O=c1oc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	162672029	182313	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	8	1	7	5.0	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cc(Cl)c4oc(=O)cc(C)c4c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4792307	182313	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	534	8	1	7	5.0	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3cc(Cl)c4oc(=O)cc(C)c4c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	11047201	51831	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
	CHEMBL158770	51831	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1	10.1021/jm020994z
	127051015	140330	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818128	140330	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819731	140330	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	162673636	183181	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4796041	183181	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4803955	183181	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	11	1	4	5.5	CCC(C)c1ccc(NC(=O)CCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	276	3444	45	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	5312149	3444	45	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	CHEMBL431298	3444	45	None	-100	13	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
	156010187	176530	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4633600	176530	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
	20923078	117419	5	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	4	2	5	3.2	O=c1ccc(-c2ccc(S(=O)(=O)Nc3cccc4c3CCCC4)s2)n[nH]1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403339	117419	5	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	4	2	5	3.2	O=c1ccc(-c2ccc(S(=O)(=O)Nc3cccc4c3CCCC4)s2)n[nH]1	10.1016/j.bmcl.2015.03.049
	1353	1872	85	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	3559	1872	85	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	86	1872	85	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	CHEMBL54	1872	85	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	DB00502	1872	85	None	-120	86	Rat	6.6	pKi	=	6.6	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030030n
	52952422	62248	0	None	12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	5	1	5	4.4	N#Cc1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782809	62248	0	None	12	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	391	5	1	5	4.4	N#Cc1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	11329844	84721	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	CHEMBL225171	84721	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)cc1	10.1021/jm049702f
	127026144	137148	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	415	7	2	3	5.1	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758684	137148	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	415	7	2	3	5.1	CC(C)c1ccccc1OCCN1CCC(NC(=O)Nc2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
	1830	2542	39	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	207	2542	39	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	23897	2542	39	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	CHEMBL460	2542	39	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	DB01618	2542	39	None	-30	28	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1021/jm030030n
	134151428	154003	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3978642	154003	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	CHEMBL3991094	154003	0	None	-10	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	3	0	2	3.5	O=C1c2ccccc2CC1CCN1CCc2ccccc2C1	10.1016/j.bmc.2016.09.019
	5216959	8509	5	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	363	8	2	5	2.6	OC(CNCC1COc2ccccc2O1)COCc1ccccc1Cl	10.1016/j.bmcl.2010.03.012
	CHEMBL1094908	8509	5	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	363	8	2	5	2.6	OC(CNCC1COc2ccccc2O1)COCc1ccccc1Cl	10.1016/j.bmcl.2010.03.012
	1816	2494	99	None	-165	17	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	4205	2494	99	None	-165	17	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	7241	2494	99	None	-165	17	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	CHEMBL654	2494	99	None	-165	17	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	DB00370	2494	99	None	-165	17	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
	155562202	175235	0	None	-26	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4584719	175235	0	None	-26	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
	888311	198988	40	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	243	4	0	2	2.4	CN(C)CCOc1ccccc1Br	10.1016/j.bmc.2010.01.035
	CHEMBL599818	198988	40	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	243	4	0	2	2.4	CN(C)CCOc1ccccc1Br	10.1016/j.bmc.2010.01.035
	22549784	117421	5	None	-2	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	418	4	0	4	4.9	COc1cccc(-n2cc(C(=O)N(C)c3cccc(Cl)c3)c3ccccc3c2=O)c1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403340	117421	5	None	-2	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	418	4	0	4	4.9	COc1cccc(-n2cc(C(=O)N(C)c3cccc(Cl)c3)c3ccccc3c2=O)c1	10.1016/j.bmcl.2015.03.049
	57393876	68060	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917338	68060	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	155536631	171644	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
	CHEMBL4474014	171644	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
	162653993	183076	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4753809	183076	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4802865	183076	0	None	-15	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3cccnc3)CC2)cc1	10.1016/j.bmc.2020.115943
	44424657	85320	0	None	-10	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229179	85320	0	None	-10	3	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	42618262	180979	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	486	9	0	7	4.4	COc1ccc(-n2c(=O)n(CCCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	CHEMBL476821	180979	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	486	9	0	7	4.4	COc1ccc(-n2c(=O)n(CCCCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	164619936	185617	0	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	415	7	0	7	1.6	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4873100	185617	0	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	415	7	0	7	1.6	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2021.128028
	71462064	80735	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	3	5.2	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158028	80735	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	3	5.2	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1	10.1016/j.ejmech.2012.07.043
	10740969	98616	0	None	-3	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	7	1	5	3.4	COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	CHEMBL28063	98616	0	None	-3	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	7	1	5	3.4	COc1ccccc1N1CCN(CCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	155536631	171644	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
	CHEMBL4474014	171644	0	None	-6	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	339	4	0	3	3.5	Fc1ccc2c(c1)CC(CCN1CCCN(c3ccccn3)CC1)C2	10.1016/j.bmc.2020.115943
	452533	119496	5	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	265	5	0	5	2.9	CN(C)CCSc1nc(-c2ccncc2)cs1	10.1016/j.bmcl.2003.11.050
	CHEMBL350166	119496	5	None	3	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	265	5	0	5	2.9	CN(C)CCSc1nc(-c2ccncc2)cs1	10.1016/j.bmcl.2003.11.050
	122181252	121329	0	None	-2	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	452	6	1	4	3.6	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3589978	121329	0	None	-2	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	452	6	1	4	3.6	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	76325349	105923	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121436	105923	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139519	105923	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	383	4	1	4	4.7	Oc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	127026120	137268	0	None	7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	9	1	5	3.4	CC(C)Oc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759651	137268	0	None	7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	436	9	1	5	3.4	CC(C)Oc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	134131976	144430	0	None	34	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	509	10	1	5	5.2	N#Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccc(F)cc3-c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3910730	144430	0	None	34	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	509	10	1	5	5.2	N#Cc1ccc(CNC(=O)CCCCCN2CCN(c3ccc(F)cc3-c3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	71449549	80740	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	11	1	6	3.9	COc1ccc(OC)c(S(=O)(=O)NCC2CCN(CCOc3ccccc3C(C)C)CC2)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158033	80740	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	476	11	1	6	3.9	COc1ccc(OC)c(S(=O)(=O)NCC2CCN(CCOc3ccccc3C(C)C)CC2)c1	10.1016/j.ejmech.2012.07.043
	71462179	81003	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	5	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159472	81003	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	5	3.1	O=S(=O)(NC1CCN(CCOc2cccc3c2CCCC3)C1)c1cccs1	10.1016/j.ejmech.2012.07.043
	71574304	85824	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2cccnc12	10.1016/j.ejmech.2012.11.042
	CHEMBL2312638	85824	0	None	1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2cccnc12	10.1016/j.ejmech.2012.11.042
	117209962	184276	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184276	1	None	4	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	156020705	177493	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	328	2	1	3	2.8	CN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4647589	177493	0	None	4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	328	2	1	3	2.8	CN1CCc2cccc3c2C1Cc1ccc(NS(C)(=O)=O)cc1-3	10.1016/j.bmc.2020.115578
	2726	904	64	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	621	904	64	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	83	904	64	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	CHEMBL71	904	64	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	DB00477	904	64	None	-13	73	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmc.2011.08.033
	127051015	140330	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818128	140330	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819731	140330	0	None	5	9	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	9865858	162742	0	None	-16	8	Rat	7.6	pKi	=	7.6	Binding	The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptorThe compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	402	6	1	5	4.0	COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1	10.1021/jm9910122
	CHEMBL418854	162742	0	None	-16	8	Rat	7.6	pKi	=	7.6	Binding	The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptorThe compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor	ChEMBL	402	6	1	5	4.0	COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1	10.1021/jm9910122
	10355252	14848	0	None	2	3	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3cnc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL120927	14848	0	None	2	3	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3cnc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	44266253	97693	1	None	35	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL273821	97693	1	None	35	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	405	4	0	5	3.3	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	44324325	106660	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1ccc(-c2cccc(NC3=NCCN3)c2C)cc1	10.1016/s0960-894x(02)00925-3
	CHEMBL316283	106660	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1ccc(-c2cccc(NC3=NCCN3)c2C)cc1	10.1016/s0960-894x(02)00925-3
	10683945	97581	0	None	6	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@]3(C)O	10.1021/jm9911433
	CHEMBL27309	97581	0	None	6	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@]3(C)O	10.1021/jm9911433
	155558563	174177	0	None	-13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	402	6	1	5	3.8	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	CHEMBL4561000	174177	0	None	-13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	402	6	1	5	3.8	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	23111951	68056	10	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	330	6	1	3	2.4	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917334	68056	10	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	330	6	1	3	2.4	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	68281137	111575	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	9	1	7	3.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289974	111575	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	9	1	7	3.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	168284109	190143	0	None	-151	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	420	7	0	7	2.3	COc1ccccc1N1CCN(CCCN2CCN(c3ncccc3C#N)CC2)CC1	10.1016/j.ejmech.2022.114193
	CHEMBL5182877	190143	0	None	-151	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	420	7	0	7	2.3	COc1ccccc1N1CCN(CCCN2CCN(c3ncccc3C#N)CC2)CC1	10.1016/j.ejmech.2022.114193
	44408998	139849	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	6	0	3	3.6	O=S(=O)(c1ccccc1)C1(CCCN2CCCCC2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL380863	139849	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	321	6	0	3	3.6	O=S(=O)(c1ccccc1)C1(CCCN2CCCCC2)CCC1	10.1016/j.bmcl.2005.11.067
	44439402	168801	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	2	1	2	3.4	OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL442093	168801	0	None	1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	292	2	1	2	3.4	OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21	10.1016/j.bmcl.2007.01.093
	168279047	190581	0	None	-269	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	437	8	0	8	2.7	O=c1n(CCCCCCN2CCN(c3cccc4c3OCCO4)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5189101	190581	0	None	-269	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	437	8	0	8	2.7	O=c1n(CCCCCCN2CCN(c3cccc4c3OCCO4)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	53323187	56708	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644278	56708	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1cccc(-c2cn(Cc3ccccc3)c3c2CNCC3)c1	10.1016/j.bmcl.2010.11.078
	58405225	110197	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	323	6	1	6	2.8	CC(C)c1noc(COc2ccc(Cl)cc2OC2CNC2)n1	10.1021/ml500082j
	CHEMBL3260338	110197	0	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	323	6	1	6	2.8	CC(C)c1noc(COc2ccc(Cl)cc2OC2CNC2)n1	10.1021/ml500082j
	155538144	171820	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	295	3	1	3	4.0	CCn1cncc1-c1c[nH]c2ccc(OC(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4476520	171820	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	295	3	1	3	4.0	CCn1cncc1-c1c[nH]c2ccc(OC(F)(F)F)cc12	10.1016/j.ejmech.2019.03.017
	164617626	184868	0	None	-9	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4861794	184868	0	None	-9	7	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	324	6	1	5	2.4	Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	155565813	175225	0	None	-1380	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4cc(F)ccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4584504	175225	0	None	-1380	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4cc(F)ccc34)o2)cc1	10.1016/j.ejmech.2019.111857
	145975992	162952	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	393	4	1	3	3.6	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4202520	162952	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	393	4	1	3	3.6	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	164608999	183792	0	None	-18	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4845741	183792	0	None	-18	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	310	6	1	4	2.8	Nc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	71602640	89238	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2376450	89238	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	52952424	62251	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	360	5	1	5	3.1	OC(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
	CHEMBL1782812	62251	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	360	5	1	5	3.1	OC(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
	45268647	194561	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	414	7	3	3	3.1	Cc1cccc(S(=O)(=O)NCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	CHEMBL561750	194561	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	414	7	3	3	3.1	Cc1cccc(S(=O)(=O)NCCCNC(=N)N2CCC(c3ccccc3)CC2)c1	10.1016/j.bmcl.2009.06.038
	71449627	80933	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	4	4.7	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159307	80933	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	4	4.7	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccs1	10.1016/j.ejmech.2012.07.043
	53377238	66027	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851686	66027	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216945	66027	0	None	-45	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	134131283	141600	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	8	0	5	4.3	Cc1nc(OCCCCCN2CCN(c3ccccc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
	CHEMBL3883517	141600	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	8	0	5	4.3	Cc1nc(OCCCCCN2CCN(c3ccccc3)CC2)c2ccccc2n1	10.1016/j.bmc.2016.12.039
	71602640	89238	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2376450	89238	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	342	4	0	2	5.0	Cc1ccc(N2CCN(Cc3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	155552311	173459	0	None	-19	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4543646	173459	0	None	-19	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	446	5	0	4	3.9	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	155539605	172266	0	None	-12	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4514672	172266	0	None	-12	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
	168291617	191427	0	None	-17	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	413	8	0	6	3.5	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5202054	191427	0	None	-17	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant	ChEMBL	413	8	0	6	3.5	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	24768525	143377	0	None	-7	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL390213	143377	0	None	-7	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	145961372	161047	0	None	-128	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	311	7	0	2	5.3	c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	CHEMBL4129589	161047	0	None	-128	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hrDisplacement of [3H]-5-carboxyamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr	ChEMBL	311	7	0	2	5.3	c1ccc2c(OCCCCCN3CCCCCC3)cccc2c1	10.1016/j.bmc.2018.04.023
	90654688	109607	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	489	9	1	6	3.3	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235760	109607	0	None	3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	489	9	1	6	3.3	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	127042540	136586	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747744	136586	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	71449645	81021	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159490	81021	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	25125375	177252	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	281	3	0	2	3.8	COc1cccc(-c2cccc3c2CCC(N(C)C)C3)c1	10.1016/j.bmc.2019.115262
	CHEMBL4644005	177252	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	281	3	0	2	3.8	COc1cccc(-c2cccc3c2CCC(N(C)C)C3)c1	10.1016/j.bmc.2019.115262
	127040761	136289	0	None	13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)c(F)c2)CC1	10.1039/C5MD00166H
	CHEMBL3741657	136289	0	None	13	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)c(F)c2)CC1	10.1039/C5MD00166H
	24873384	182009	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4788223	182009	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	118709739	113019	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	334	6	0	2	3.8	O=C1Cc2ccccc2N1CCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321777	113019	0	None	18	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	334	6	0	2	3.8	O=C1Cc2ccccc2N1CCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	122178703	120842	0	None	1	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581248	120842	0	None	1	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	162646653	178912	0	None	-18	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
	CHEMBL4741142	178912	0	None	-18	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	419	7	1	5	3.5	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc(Cl)c1	10.1016/j.ejmech.2020.112149
	44324536	205105	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	269	2	2	3	3.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(F)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL90538	205105	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	269	2	2	3	3.2	Cc1c(NC2=NCCN2)cccc1-c1cccc(F)c1	10.1016/s0960-894x(02)00925-3
	11785077	84729	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	CHEMBL225252	84729	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	44437332	91140	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL240729	91140	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	763	23	0	8	9.0	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	11143090	51919	1	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	9	0	4	4.3	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
	CHEMBL158850	51919	1	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	9	0	4	4.3	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
	44437328	90537	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239656	90537	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	678	17	0	8	6.7	COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	142601343	185011	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185011	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	160510	100645	36	None	3	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
	CHEMBL1506260	100645	36	None	3	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
	CHEMBL295234	100645	36	None	3	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	184	0	1	1	2.5	CC1=NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2003.09.027
	155511929	175693	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4436319	175693	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595069	175693	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2019.06.028
	13069603	120083	0	None	-53	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360993	120083	0	None	-53	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546107	120083	0	None	-53	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	416	5	0	8	1.3	Cn1c(=O)c2c(ncn2CCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	168281754	190300	0	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	434	6	0	8	2.7	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccn5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5185101	190300	0	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	434	6	0	8	2.7	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccn5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	122483218	137571	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764418	137571	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765877	137571	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	57390695	70108	0	None	-21	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	427	7	0	5	5.5	O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL1946257	70108	0	None	-21	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	427	7	0	5	5.5	O=C(CCCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	24768518	92393	0	None	-46	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243743	92393	0	None	-46	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	122483218	137571	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764418	137571	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765877	137571	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	425	7	0	4	5.4	O=C(CCCCN1CCN(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	76328890	105924	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121414	105924	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139522	105924	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	278	4	0	2	4.0	Cc1ccccc1-n1cc(CCN(C)C)c2ccccc21	10.1016/j.ejmech.2014.01.055
	44347445	16101	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3c(=O)oc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL122485	16101	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	277	0	0	3	3.0	CN1CCc2ccc3c(=O)oc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	145972025	163916	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	409	4	1	3	4.1	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4214208	163916	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	409	4	1	3	4.1	O=C1Nc2ccccc2C12CCN(CCN1CCC(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	127026142	137218	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	384	7	1	3	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759273	137218	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	384	7	1	3	4.2	CC(C)c1ccccc1OCCN1CCC(NC(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	155524957	175761	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4455845	175761	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595569	175761	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	127049061	140223	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3818398	140223	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	44582708	186246	0	None	-19	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	CHEMBL489408	186246	0	None	-19	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	155554462	174019	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	316	4	1	7	1.5	CN1CCN(c2nc(N)nc(CSc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4557247	174019	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	316	4	1	7	1.5	CN1CCN(c2nc(N)nc(CSc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	44460759	103736	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	275	3	0	3	2.4	CN1CCCN(CCn2ccc3ccc(F)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL309908	103736	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	275	3	0	3	2.4	CN1CCCN(CCn2ccc3ccc(F)cc32)CC1	10.1016/s0960-894x(02)00438-9
	127049061	140223	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3818398	140223	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	440	6	1	5	5.3	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	162663279	183126	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4779939	183126	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803352	183126	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	2	5	3.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	156013588	176617	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	353	3	2	4	2.9	COc1cc2c3c(c1OC)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4635229	176617	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	353	3	2	4	2.9	COc1cc2c3c(c1OC)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	9817810	17175	1	None	-12	9	Human	7.5	pKi	=	7.5	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	300	4	1	4	2.4	NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	CHEMBL125745	17175	1	None	-12	9	Human	7.5	pKi	=	7.5	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	300	4	1	4	2.4	NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	137652310	156696	0	None	4	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4076525	156696	0	None	4	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	482	6	0	5	4.0	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(F)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	57399092	68077	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	468	9	0	6	3.5	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917355	68077	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	468	9	0	6	3.5	CCN(CCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	145969402	164255	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4218625	164255	0	None	2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	71451457	81001	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	394	8	1	5	3.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccs2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159470	81001	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	394	8	1	5	3.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccs2)C1	10.1016/j.ejmech.2012.07.043
	155543250	172717	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	275	1	1	2	3.3	Cn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4526012	172717	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	275	1	1	2	3.3	Cn1cncc1-c1c[nH]c2ccc(Br)cc12	10.1016/j.ejmech.2019.03.017
	142601343	185011	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185011	0	None	30	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	56944955	159132	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	CHEMBL4104216	159132	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12	10.1021/acs.jmedchem.7b00839
	118706284	120000	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310112	120000	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545440	120000	0	None	-31	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	118709753	113032	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	326	5	0	2	3.9	O=C1Cc2ccccc2N1CCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321795	113032	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	326	5	0	2	3.9	O=C1Cc2ccccc2N1CCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	66801335	111548	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	8	1	7	3.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289948	111548	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	8	1	7	3.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	109026956	172846	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	393	6	0	5	1.9	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4528701	172846	2	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	393	6	0	5	1.9	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2016.06.080
	11102049	102884	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	6	2	3	4.9	COc1ccc2[nH]c3c(c2c1)CCN(CCCCC12CCCc4cccc(c41)NC2=O)C3	10.1021/jm0104264
	CHEMBL308461	102884	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	6	2	3	4.9	COc1ccc2[nH]c3c(c2c1)CCN(CCCCC12CCCc4cccc(c41)NC2=O)C3	10.1021/jm0104264
	162649235	179484	0	None	-46	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
	CHEMBL4747978	179484	0	None	-46	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
	9921064	126644	18	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
	CHEMBL365751	126644	18	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
	145964154	163757	0	None	7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Cl	10.1021/acs.jmedchem.8b00828
	CHEMBL4212339	163757	0	None	7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	394	7	1	4	3.2	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccccc1Cl	10.1021/acs.jmedchem.8b00828
	53317861	56710	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	318	4	1	3	3.9	COc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644280	56710	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	318	4	1	3	3.9	COc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	155549315	173247	0	None	-144	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	448	9	0	6	4.1	COc1ccccc1N1CCN(CCCCCCn2c(=O)n3c4c(cccc42)CCC3)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4538667	173247	0	None	-144	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	448	9	0	6	4.1	COc1ccccc1N1CCN(CCCCCCn2c(=O)n3c4c(cccc42)CCC3)CC1	10.1016/j.bmcl.2019.06.029
	155519599	175729	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4447594	175729	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595274	175729	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2019.06.028
	10611439	96312	0	None	-2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	261	0	0	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3=O	10.1021/jm9911433
	CHEMBL26471	96312	0	None	-2	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	261	0	0	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3=O	10.1021/jm9911433
	57401706	69813	0	None	-50	11	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	CHEMBL1940419	69813	0	None	-50	11	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	60165681	74991	0	None	-102	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	7	0	5	5.1	O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037528	74991	0	None	-102	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	7	0	5	5.1	O=C(CCCCN1CCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	127027715	137141	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	452	7	0	4	4.0	O=S(=O)(c1ccc(F)cc1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758619	137141	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	452	7	0	4	4.0	O=S(=O)(c1ccc(F)cc1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
	71455001	81013	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159482	81013	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	4	2.5	O=S(=O)(NC1CCN(CCOc2cccc(F)c2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	142601341	184780	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	184780	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	9904281	47470	24	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	2	3	2.0	NC1=Nc2ccc(Cl)c(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	CHEMBL1548	47470	24	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	2	3	2.0	NC1=Nc2ccc(Cl)c(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	13069626	120080	0	None	-295	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3361000	120080	0	None	-295	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3546103	120080	0	None	-295	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	440	8	0	9	1.4	COc1ccccc1N1CCN(CCCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	90654682	109601	0	None	6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	7	1	4	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235754	109601	0	None	6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	7	1	4	2.6	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.03.005
	71602688	89241	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376457	89241	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
	142601341	184780	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	184780	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	11560285	68058	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917336	68058	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2ccccc12	10.1016/j.bmc.2011.09.044
	53377241	66298	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1852852	66298	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216488	66298	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	427	6	0	6	3.9	Cc1ccccc1N1CCN(CCCCn2cnc3c(cnc4ccccc43)c2=O)CC1	10.1016/j.ejmech.2011.04.060
	25107717	186957	0	None	-6	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	CHEMBL494512	186957	0	None	-6	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	42618260	180958	0	None	-13	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	458	7	0	7	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	CHEMBL476615	180958	0	None	-13	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	458	7	0	7	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4OC)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	417052	116342	37	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1016/j.bmcl.2003.09.027
	CHEMBL338115	116342	37	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	214	1	1	2	2.5	COc1ccc2[nH]c3c(c2c1)CCN=C3C	10.1016/j.bmcl.2003.09.027
	71602688	89241	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376457	89241	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	392	5	0	3	5.3	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2013.02.038
	155514889	169334	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	520	10	1	8	3.3	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4440973	169334	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	520	10	1	8	3.3	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	11283795	141496	0	None	3	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	483	9	1	5	4.0	CS(=O)(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL387738	141496	0	None	3	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	483	9	1	5	4.0	CS(=O)(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	56850390	71125	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926733	71125	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962486	71125	0	None	-245	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	46204421	124028	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
	CHEMBL3640568	124028	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
	46206021	124068	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640607	124068	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
	46204421	124028	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
	CHEMBL3640568	124028	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	343	5	0	3	4.6	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C2CCC2)C1	nan
	46206021	124068	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
	CHEMBL3640607	124068	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	253	3	1	2	3.4	COc1ccccc1-c1ccccc1C1CCNC1	nan
	90469115	185250	2	None	-1000	17	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	CHEMBL4867565	185250	2	None	-1000	17	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	10154897	64917	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.ejmech.2019.111705
	CHEMBL182797	64917	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.ejmech.2019.111705
	86288948	112116	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL3233679	112116	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL3302600	112116	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2019.111705
	44393228	64452	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cc(NCCc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL181950	64452	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	317	7	2	3	4.9	C[C@H](Nc1cc(NCCc2ccccc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	12088080	64534	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	C[C@H](Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182174	64534	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	C[C@H](Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	44393069	65745	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	8	2	6	3.5	C[C@H](Nc1ncnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL183862	65745	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	8	2	6	3.5	C[C@H](Nc1ncnc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	11151899	2097	10	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
	8432	2097	10	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
	CHEMBL4205783	2097	10	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2021.128275
	9863250	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030030n
	CHEMBL12624	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030030n
	9885982	103694	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	CHEMBL309750	103694	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	9885982	103694	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL309750	103694	0	None	1348	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	3	0	3	4.0	Brc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	9863250	17796	4	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm049743b
	CHEMBL12624	17796	4	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm049743b
	118626121	164857	0	None	1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238479	164857	0	None	1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145983961	164862	0	None	-3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238679	164862	0	None	-3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	86288948	112116	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233679	112116	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302600	112116	0	None	39	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1	10.1016/j.ejmech.2014.01.065
	145990353	166234	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc4ccccc4c3)C2=O)CC1	10.1039/C8MD00168E
	CHEMBL4284331	166234	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc4ccccc4c3)C2=O)CC1	10.1039/C8MD00168E
	145988738	166661	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2ccc3ccccc3c2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4292237	166661	0	None	42	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	483	6	2	6	2.7	CC1(c2ccc3ccccc3c2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1039/C8MD00168E
	276	3444	45	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
	5312149	3444	45	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
	CHEMBL431298	3444	45	None	-100	13	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter methodDisplacement of [3H]-LSD from human 5HT6 receptor expressed in BHK cell membrane measured after 60 mins by scintillation counter method	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.ejmech.2020.113059
	10495891	98634	0	None	6	3	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL280804	98634	0	None	6	3	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	319	3	0	2	4.4	CCO[C@@]1(CC)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	90656710	110475	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	310	6	1	3	3.5	Oc1cccc(CCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262410	110475	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	310	6	1	3	3.5	Oc1cccc(CCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	9863250	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.7b01898
	CHEMBL12624	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/acs.jmedchem.7b01898
	5	139	66	None	-3	55	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	5202	139	66	None	-3	55	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	CHEMBL39	139	66	None	-3	55	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	DB08839	139	66	None	-3	55	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	44364048	38887	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	262	6	3	3	2.3	NCCCC1(CCCN)CCc2cccc(O)c2C1	10.1021/jm0341204
	CHEMBL146942	38887	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	262	6	3	3	2.3	NCCCC1(CCCN)CCc2cccc(O)c2C1	10.1021/jm0341204
	9863250	17796	4	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/s0960-894x(00)00166-9
	CHEMBL12624	17796	4	None	1	7	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/s0960-894x(00)00166-9
	9863250	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
	CHEMBL12624	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm991151j
	9863250	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
	CHEMBL12624	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1021/jm030841r
	10500557	16486	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL12427	16486	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	10500557	16486	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	CHEMBL12427	16486	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	9863250	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/j.ejmech.2019.111705
	CHEMBL12624	17796	4	None	-1	7	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	350	5	0	3	3.3	Cc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1	10.1016/j.ejmech.2019.111705
	2389	3267	114	None	-9	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	5073	3267	114	None	-9	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	96	3267	114	None	-9	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	CHEMBL85	3267	114	None	-9	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	DB00734	3267	114	None	-9	68	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2015.09.045
	10028436	3463	3	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
	3237	3463	3	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
	CHEMBL95104	3463	3	None	-1	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/j.ejmech.2012.07.043
	145977297	163071	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	350	4	1	3	3.8	OC(CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2017.11.007
	CHEMBL4203932	163071	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method	ChEMBL	350	4	1	3	3.8	OC(CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2017.11.007
	66801230	111551	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	436	8	1	7	3.2	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289951	111551	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	436	8	1	7	3.2	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	56943600	111610	0	None	-5	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	8	1	5	5.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3290008	111610	0	None	-5	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	515	8	1	5	5.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	66801186	111620	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	7	3.2	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3290018	111620	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	7	3.2	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	155545402	172807	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-HT from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]-HT from human 5HT7 receptor expressed in CHO cells	ChEMBL	391	6	1	3	3.8	O=C1NC2C=CC=C3CCCC1(CCCCN1CCN(c4ccccc4)CC1)C32	10.1016/j.ejmech.2019.111690
	CHEMBL4527987	172807	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-HT from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]-HT from human 5HT7 receptor expressed in CHO cells	ChEMBL	391	6	1	3	3.8	O=C1NC2C=CC=C3CCCC1(CCCCN1CCN(c4ccccc4)CC1)C32	10.1016/j.ejmech.2019.111690
	11536844	114611	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	114611	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	145987771	166525	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.ejmech.2017.12.063
	CHEMBL4289783	166525	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method	ChEMBL	431	6	1	2	5.9	Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.ejmech.2017.12.063
	44276598	95226	0	None	-1	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0108505
	CHEMBL25815	95226	0	None	-1	4	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	386	6	1	2	5.2	O=C1Nc2cccc3c2[C@]1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0108505
	8431	1451	6	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
	9843179	1451	6	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
	CHEMBL69257	1451	6	None	22	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1016/j.bmcl.2009.12.027
	10500557	16486	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL12427	16486	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	10500557	16486	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	CHEMBL12427	16486	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	389	6	1	3	4.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	10825325	98952	0	None	1	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL282863	98952	0	None	1	5	Rat	8.5	pKi	=	8.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	11267988	66480	0	None	-2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
	CHEMBL186112	66480	0	None	-2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	309	6	0	2	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2010.01.035
	11186985	123315	0	None	-3	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
	CHEMBL362540	123315	0	None	-3	4	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1021/jm0498102
	23369416	181895	2	None	-3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL478680	181895	2	None	-3	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	66801379	111566	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	8	3.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3289966	111566	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	8	3.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	24854267	157347	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	385	6	1	3	4.0	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm070279v
	CHEMBL408426	157347	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	385	6	1	3	4.0	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm070279v
	155512409	169066	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	6	0	6	4.3	Cn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
	CHEMBL4437217	169066	0	None	1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	6	0	6	4.3	Cn1c(CCCCN2CCN(c3ccccc3)CC2)nc2c(sc3ccccc32)c1=O	10.1016/j.ejmech.2019.111690
	155546781	173046	0	None	36	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CN(CCCCC13CCCc4cccc(c41)NC3=O)CC2	10.1016/j.ejmech.2019.111705
	CHEMBL4533865	173046	0	None	36	2	Human	8.5	pKi	=	8.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CN(CCCCC13CCCc4cccc(c41)NC3=O)CC2	10.1016/j.ejmech.2019.111705
	11025847	162745	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL418888	162745	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	11025847	162745	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL418888	162745	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CC=C(c2ccc(F)cc2)CC1)CCC3	10.1021/jm0104264
	9956365	193836	0	None	34	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL553794	193836	0	None	34	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	91864602	140194	0	None	2	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818047	140194	0	None	2	8	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	9956365	193836	0	None	34	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm070279v
	CHEMBL553794	193836	0	None	34	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm070279v
	91864602	140194	0	None	2	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818047	140194	0	None	2	8	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	11016205	203050	1	None	-2	5	Human	8.4	pKi	=	8.4	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
	CHEMBL74756	203050	1	None	-2	5	Human	8.4	pKi	=	8.4	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccccc2I)CC1	10.1021/jm0200411
	11978813	712	72	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	5014	712	72	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	7672	712	72	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	CHEMBL2105760	712	72	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	DB09128	712	72	None	-6	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	4106	2456	16	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	5358812	2456	16	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	89	2456	16	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	CHEMBL93240	2456	16	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	24854044	96837	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
	CHEMBL269083	96837	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
	46196448	124009	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640550	124009	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	11725453	98610	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
	CHEMBL28056	98610	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030030n
	46196448	124009	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	CHEMBL3640550	124009	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	323	4	1	3	3.7	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CNC1	nan
	11725453	98610	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL28056	98610	0	None	1	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2020.115578
	11725453	98610	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL28056	98610	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	11725453	98610	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0498102
	CHEMBL28056	98610	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0498102
	66800942	111540	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	416	6	1	6	2.7	Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	CHEMBL3289708	111540	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	416	6	1	6	2.7	Cc1cccc(S(=O)(=O)NCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1021/jm401895u
	11465618	101913	18	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL3039528	101913	18	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL5191141	101913	18	None	-14	19	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5-HT7 receptor measured after 120 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	10811746	97607	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL273246	97607	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	10811746	97607	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
	CHEMBL273246	97607	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
	25107648	186630	0	None	25	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	CHEMBL492480	186630	0	None	25	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	10.1021/jm800615e
	76284724	104512	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	490	11	1	5	4.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113593	104512	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	490	11	1	5	4.9	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	11047374	18706	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL12846	18706	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	388	6	1	2	5.3	O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	10835110	114077	0	None	79	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm991151j
	CHEMBL333784	114077	0	None	79	8	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm991151j
	44368732	45873	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
	CHEMBL153398	45873	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	404	5	0	3	4.3	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
	11725453	98610	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	CHEMBL28056	98610	0	None	-1	6	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligandBinding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand	ChEMBL	350	1	0	2	5.3	Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm030841r
	10811746	97607	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL273246	97607	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
	10811746	97607	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
	CHEMBL273246	97607	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	414	6	1	4	4.1	N#Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
	162656718	180366	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
	CHEMBL4758402	180366	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
	4106	2456	16	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
	5358812	2456	16	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
	89	2456	16	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
	CHEMBL93240	2456	16	None	-4	34	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2019.111705
	145	140	48	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
	1832	140	48	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
	CHEMBL7257	140	48	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
	DB14010	140	48	None	-2	30	Human	7.5	pKi	=	7.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030030n
	398712	77501	5	None	-30	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	CHEMBL209324	77501	5	None	-30	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	122483281	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763779	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765873	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL5083607	213091	0	None	-2	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	71574212	85843	0	None	-3	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312935	85843	0	None	-3	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	118731349	117670	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	3.5	CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409033	117670	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	3.5	CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	118731359	117679	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	532	10	0	5	4.3	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409042	117679	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	532	10	0	5	4.3	O=C([C@@H]1CCCN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	156014079	176672	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2ccccc12	10.1016/j.bmc.2020.115459
	CHEMBL4636031	176672	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1cccc2ccccc12	10.1016/j.bmc.2020.115459
	138691338	163104	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4204595	163104	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1016/j.ejmech.2019.03.017
	11425677	181743	0	None	-1	4	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4784424	181743	0	None	-1	4	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	138691338	163104	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.7b01898
	CHEMBL4204595	163104	0	None	21	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	241	3	1	3	3.1	CCn1cncc1-c1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.7b01898
	90656694	110493	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262428	110493	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	339	7	1	4	3.4	CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	10171	57	15	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
	272	57	15	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
	CHEMBL274384	57	15	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1021/jm030030n
	122483281	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763779	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765873	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	67268994	163405	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163405	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	118736368	118422	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	527	7	1	10	2.7	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423332	118422	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	527	7	1	10	2.7	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	11786227	172026	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)CCCC2NC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	CHEMBL449089	172026	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)CCCC2NC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	118728510	117189	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	5	4.1	Cc1sc2nc(CCCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401473	117189	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	1	5	4.1	Cc1sc2nc(CCCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL5083607	213091	0	None	-2	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	122483281	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763779	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765873	137567	0	None	-6	8	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	12	1518	14	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
	6918513	1518	14	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
	CHEMBL267615	1518	14	None	-13	7	Human	6.5	pKi	=	6.5	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10.1021/jm990550b
	162671716	183170	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4792591	183170	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803839	183170	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	3.3	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	44439405	91366	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	440	4	0	5	5.3	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1CC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL241282	91366	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	440	4	0	5	5.3	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C1SCCSC1CC3)CC2	10.1016/j.bmcl.2007.01.093
	72711487	102108	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
	CHEMBL2431040	102108	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
	CHEMBL3040890	102108	0	None	-11	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	411	10	1	5	3.0	COc1ccc(OCCNCCCCN2C(=O)C3CCCN3C2=O)c2ccccc12	10.1021/jm400766k
	57399088	68059	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCCN(CCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917337	68059	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	373	8	1	4	2.1	NCCCN(CCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	90654676	109595	0	None	-25	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	464	9	1	5	2.8	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235748	109595	0	None	-25	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	464	9	1	5	2.8	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	138691366	174376	0	None	7	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2ccc(F)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4565881	174376	0	None	7	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2ccc(F)cc12	10.1016/j.ejmech.2019.03.017
	145946733	167008	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	CHEMBL4205526	167008	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300710	167008	0	None	-20	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	173	3199	88	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
	5011	3199	88	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
	CHEMBL18772	3199	88	None	-34	23	Human	5.5	pKi	=	5.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	10.1021/jm030030n
	1355	1972	82	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
	142	1972	82	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
	CHEMBL478	1972	82	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
	DB12110	1972	82	None	-14	16	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm030030n
	134144798	149702	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	325	5	0	3	4.6	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3952371	149702	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	325	5	0	3	4.6	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	118728521	117200	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401484	117200	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	376	7	0	5	3.4	O=c1c2ccccc2ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2015.02.042
	156019563	177403	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	364	5	0	4	4.1	C=CCOc1c(OC)cc2c3c1-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4646172	177403	0	None	-3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	364	5	0	4	4.1	C=CCOc1c(OC)cc2c3c1-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	71602691	89244	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376460	89244	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
	122483260	137559	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763275	137559	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765848	137559	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	11121216	29910	0	None	-15	15	Human	7.5	pKi	=	7.5	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL138989	29910	0	None	-15	15	Human	7.5	pKi	=	7.5	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	88912137	110196	0	None	19	4	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
	CHEMBL3260337	110196	0	None	19	4	Rat	7.5	pKi	=	7.5	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
	44460471	203863	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81424	203863	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	145986138	164906	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239705	164906	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	71574302	85823	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312637	85823	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	71574208	85828	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312642	85828	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ncccc2c1	10.1016/j.ejmech.2012.11.042
	156019543	177352	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2020.115459
	CHEMBL4645525	177352	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	508	10	1	6	5.1	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2020.115459
	90654854	112173	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233676	112173	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304183	112173	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.01.065
	156009483	176482	0	None	7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	412	5	1	5	2.8	C#CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4632872	176482	0	None	7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	412	5	1	5	2.8	C#CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	42618272	90754	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.6	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239898	90754	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	435	6	0	4	3.6	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.07.029
	25107517	186663	0	None	-1	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL492690	186663	0	None	-1	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	72551082	113569	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccccc1-c1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326985	113569	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccccc1-c1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.07.026
	11168662	84195	0	None	-1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	CHEMBL222262	84195	0	None	-1	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.ejmech.2019.111705
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/acs.jmedchem.7b01898
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/j.bmc.2013.02.038
	281	3441	22	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
	5312148	3441	22	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
	CHEMBL12264	3441	22	None	-1	5	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm0108505
	3233	3443	40	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	3247	3443	40	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	6604889	3443	40	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	CHEMBL282199	3443	40	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	DB13988	3443	40	None	-2	12	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm030841r
	9820952	18536	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm970519e
	CHEMBL12777	18536	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm970519e
	10715573	98026	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm970519e
	CHEMBL275996	98026	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm970519e
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(00)00166-9
	9820952	18536	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12777	18536	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1016/s0960-894x(00)00166-9
	10715573	98026	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL275996	98026	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	392	6	0	3	4.1	CC1CCN(CC[C@@H](C)N(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(00)00166-9
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	44368358	119154	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	CHEMBL347115	119154	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030841r
	44368306	164326	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	391	6	0	3	4.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
	CHEMBL422146	164326	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	391	6	0	3	4.9	CC1CCN(CC[C@@H](C)C(C)S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm030841r
	142601337	185378	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185378	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	162674561	182679	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
	CHEMBL4796647	182679	0	None	-2	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	403	7	1	5	3.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)cc1	10.1016/j.ejmech.2020.112149
	10171	57	15	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
	272	57	15	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
	CHEMBL274384	57	15	None	-11	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	10.1016/j.ejmech.2019.111705
	67268994	163405	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163405	2	None	3	7	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	2726	904	64	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	621	904	64	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	83	904	64	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	CHEMBL71	904	64	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	DB00477	904	64	None	-13	73	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	44324627	205028	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1ccsc1	10.1016/s0960-894x(02)00925-3
	CHEMBL90118	205028	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	257	2	2	4	3.1	Cc1c(NC2=NCCN2)cccc1-c1ccsc1	10.1016/s0960-894x(02)00925-3
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT. The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.The compound was tested for its binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm970519e
	57403839	71187	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949967	71187	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963008	71187	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	90656708	110492	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	415	8	1	4	5.5	CN(CCCN1CCC(N(c2ccccc2)c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262427	110492	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	415	8	1	4	5.5	CN(CCCN1CCC(N(c2ccccc2)c2ccccc2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	46205699	124061	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
	CHEMBL3640600	124061	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
	46205699	124061	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
	CHEMBL3640600	124061	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1cccc(-c2ccccc2C2CCN(C)C2)c1	nan
	71449550	80741	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	9	1	4	4.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158034	80741	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	410	9	1	4	4.5	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2C(C)C)CC1	10.1016/j.ejmech.2012.07.043
	71602691	89244	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376460	89244	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	372	5	0	3	5.0	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2C)CC1	10.1016/j.bmc.2013.02.038
	156014279	176646	0	None	-20	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	348	5	1	2	5.0	CCCC(=O)Nc1ccc2c(c1)-c1cccc3c1C(C2)N(CCC)CC3	10.1016/j.bmc.2020.115578
	CHEMBL4635676	176646	0	None	-20	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	348	5	1	2	5.0	CCCC(=O)Nc1ccc2c(c1)-c1cccc3c1C(C2)N(CCC)CC3	10.1016/j.bmc.2020.115578
	122483260	137559	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3763275	137559	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765848	137559	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	424	7	0	3	6.6	O=C(CCCCN1CCC(Cc2ccccc2)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	145973487	164057	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4216022	164057	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
	127052486	140279	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819153	140279	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
	90654698	109582	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235735	109582	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	390	8	1	4	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2014.03.005
	145947944	167159	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4208428	167159	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4302764	167159	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	336	9	1	5	1.6	Cc1cc(C)c(C)c(OCCOCCN2CCN(CCO)CC2)c1	10.1016/j.bmcl.2018.04.059
	155511262	168966	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cccc(O)c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4435528	168966	0	None	-109	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	362	7	3	4	4.5	COc1ccc2[nH]cc(CCNCc3ccc(-c4cccc(O)c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	11151899	2097	10	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
	8432	2097	10	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
	CHEMBL4205783	2097	10	None	-5	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5-CT from recombinant rat 5-HT7 receptor expressed in HEK293 cells	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.ejmech.2019.111705
	135367959	164047	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215925	164047	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	1353	1872	85	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	3559	1872	85	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	86	1872	85	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	CHEMBL54	1872	85	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	DB00502	1872	85	None	-263	86	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm070516u
	127052486	140279	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL3819153	140279	0	None	-3	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	424	6	1	5	4.8	O=c1[nH]c2cc(Cl)ccc2n1C1CCN(CCCCc2nc3ccccc3o2)CC1	10.1016/j.bmc.2016.06.011
	145947088	167052	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4208181	167052	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4301443	167052	0	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	9	0	4	3.8	Cc1cc(C)c(OCCOCCN2CCN(Cc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	6918648	101076	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
	CHEMBL29846	101076	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
	6918648	101076	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
	CHEMBL29846	101076	1	None	-5128	14	Human	5.5	pKi	=	5.5	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
	76314436	105773	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	CHEMBL3121415	105773	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	CHEMBL3139010	105773	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	292	4	0	2	4.4	Cc1cccc(-n2cc(CCN(C)C)c3ccccc32)c1C	10.1016/j.ejmech.2014.01.055
	19958494	98981	0	None	-9	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	360	3	1	3	3.9	FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL283036	98981	0	None	-9	4	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	360	3	1	3	3.9	FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	122187	3633	14	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
	61	3633	14	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
	CHEMBL22778	3633	14	None	-104	5	Rat	5.5	pKi	=	5.5	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	265	5	1	2	3.5	CCCN([C@H]1CCc2c(C1)c(O)ccc2F)CCC	10.1021/jm9911433
	18133517	163859	0	None	16	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccc(Br)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4213576	163859	0	None	16	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccc(Br)cc2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	127027391	137294	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	7	0	4	4.5	O=S(=O)(c1cccc(Cl)c1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759885	137294	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	468	7	0	4	4.5	O=S(=O)(c1cccc(Cl)c1)N1CC2CC1CN2CCOc1ccccc1-c1ccccc1	10.1016/j.ejmech.2015.11.040
	162672202	183172	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4790910	183172	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803865	183172	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	383	8	2	5	2.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	135367959	164047	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215925	164047	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	214	1	1	3	2.0	c1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030030n
	44268087	19979	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	CHEMBL13049	19979	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1016/s0960-894x(02)00438-9
	145983794	165091	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4244280	165091	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	0	6	5.2	O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	134137332	142464	0	None	12	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2ncccc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3894679	142464	0	None	12	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	530	10	1	5	4.8	O=C(CCOCCN1CCN(c2ncccc2-c2ccc(F)cc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	145976890	163254	0	None	21	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	8	1	4	5.2	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4206203	163254	0	None	21	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	8	1	4	5.2	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.bmc.2017.03.057
	145974189	164063	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4216126	164063	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	142601337	185378	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185378	0	None	53	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	137654666	158058	0	None	-44	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4092243	158058	0	None	-44	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	10667433	148254	0	None	6	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.2	COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
	CHEMBL394080	148254	0	None	6	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	379	7	0	4	3.2	COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
	72547878	113572	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	517	12	1	6	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2c(OC)cccc2OC)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326988	113572	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	517	12	1	6	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2c(OC)cccc2OC)CC1	10.1016/j.bmc.2014.07.026
	155568373	175510	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4591320	175510	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2cccc(Cl)c2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	25107515	186767	0	None	-16	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL493305	186767	0	None	-16	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	155568246	175516	0	None	-138	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	528	9	2	5	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(OC)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL4591440	175516	0	None	-138	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	528	9	2	5	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(OC)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	44374227	167790	2	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1ncc(-c2ccccc2)s1	10.1016/j.bmcl.2003.11.050
	CHEMBL434477	167790	2	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	264	5	0	4	3.5	CN(C)CCSc1ncc(-c2ccccc2)s1	10.1016/j.bmcl.2003.11.050
	16117279	59805	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	CHEMBL1642886	59805	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	CHEMBL1739606	59805	0	None	-3235	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	121209051	163825	4	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4213135	163825	4	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	162643049	183021	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4776078	183021	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4802282	183021	0	None	-22	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	CCC(C)c1ccc(NC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	121209051	163825	4	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4213135	163825	4	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	213	1	2	2	1.8	c1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	134130846	141746	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3885178	141746	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2016.12.039
	11948707	165603	0	None	-158	13	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	CHEMBL426317	165603	0	None	-158	13	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	53377237	66042	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851771	66042	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3215834	66042	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	447	6	0	6	4.2	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2011.04.060
	162661942	183119	2	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4778949	183119	2	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803285	183119	2	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	7	2	5	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2cc(C(C)(C)C)ccc2O)CC1	10.1016/j.ejmech.2020.112437
	44424656	85314	0	None	-1	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229124	85314	0	None	-1	3	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	162668661	183149	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4789408	183149	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803658	183149	0	None	-11	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	453	8	1	6	4.2	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	71462067	80742	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	460	9	1	4	5.7	CCOc1ccccc1C(=O)NC1CCN(CCSc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158035	80742	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	460	9	1	4	5.7	CCOc1ccccc1C(=O)NC1CCN(CCSc2ccccc2-c2ccccc2)CC1	10.1016/j.ejmech.2012.07.043
	60165416	74931	0	None	-83	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037431	74931	0	None	-83	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	71459954	78757	0	None	-331	7	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	495	6	3	3	4.0	O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm049243i
	CHEMBL2113386	78757	0	None	-331	7	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	495	6	3	3	4.0	O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm049243i
	46206020	124067	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	CHEMBL3640606	124067	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	46206020	124067	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	CHEMBL3640606	124067	0	None	-	1	Rat	6.5	pKi	=	6.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	155541866	172470	0	None	-95	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4519266	172470	0	None	-95	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	44393114	63290	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1cc(NCCc2ccccc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL180087	63290	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	C[C@H](Nc1cc(NCCc2ccccc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	76336177	105777	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121412	105777	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139015	105777	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	378	4	0	2	6.2	Cc1ccccc1-n1cc(CN2CC=C(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	57399093	68082	0	None	9	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	443	9	0	4	4.9	CCN(CCCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917360	68082	0	None	9	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	443	9	0	4	4.9	CCN(CCCCCN1CCC2CCCCC2C1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	132938109	163740	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	500	9	2	5	4.2	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
	CHEMBL4212199	163740	0	None	8	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	500	9	2	5	4.2	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
	156019750	177431	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
	CHEMBL4646587	177431	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
	11666595	120008	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310115	120008	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545467	120008	0	None	-301	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	56945045	111556	0	None	-4	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	8	1	6	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3289956	111556	0	None	-4	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	514	8	1	6	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	135458393	155044	4	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	CC1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL404511	155044	4	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	259	2	2	3	2.8	CC1NC(NCC(F)F)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	24854108	157354	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	391	7	0	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)N(C)c2ccccc21	10.1021/jm070279v
	CHEMBL408429	157354	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	391	7	0	3	4.3	CCC1(CCCCN2CCN(c3ccccc3)CC2)C(=O)N(C)c2ccccc21	10.1021/jm070279v
	76335863	104517	0	None	22	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	487	11	1	5	4.5	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3C)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113598	104517	0	None	22	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	487	11	1	5	4.5	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccccc3C)CC2)cc1	10.1016/j.bmc.2014.01.016
	46203753	124011	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
	CHEMBL3640552	124011	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
	12741421	205022	7	None	-22	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	CHEMBL90053	205022	7	None	-22	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	46203753	124011	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
	CHEMBL3640552	124011	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	280	4	1	4	2.6	COc1ccc(-c2ccccc2C#N)cc1OC1CNC1	nan
	24841480	183307	0	None	-165	20	Human	6.5	pKi	=	6.5	Binding	Antagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL481153	183307	0	None	-165	20	Human	6.5	pKi	=	6.5	Binding	Antagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT7 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	127052465	140187	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL3817911	140187	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	145977799	163080	0	None	-4	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204036	163080	0	None	-4	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	162669562	182110	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4789472	182110	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	127052465	140187	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL3817911	140187	0	None	-8	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	90656716	112203	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262401	112203	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304495	112203	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	340	6	0	5	2.9	CN(CCN1CCN(c2ccccc2)CC1)c1cccc([N+](=O)[O-])c1	10.1016/j.ejmech.2014.04.034
	57393877	68072	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	5	3.4	O=S(=O)(NCCCCN1CCc2sccc2C1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917350	68072	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	5	3.4	O=S(=O)(NCCCCN1CCc2sccc2C1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.09.044
	71458516	80738	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	465	8	1	4	5.4	O=C(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158031	80738	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	465	8	1	4	5.4	O=C(NCC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	57396857	71209	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949971	71209	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963101	71209	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	472	9	1	5	4.2	O=S(=O)(NCCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	57390335	68061	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	9	1	4	2.5	NCCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917339	68061	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	387	9	1	4	2.5	NCCCN(CCCN1CCc2ccccc2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	162669562	182110	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4789472	182110	0	None	-6	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	6	0	4	4.2	O=C(CCCN1C2CCC1CN(c1ccc(Cl)cn1)C2)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	57403841	71195	0	None	-7	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949968	71195	0	None	-7	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963030	71195	0	None	-7	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	42618273	90755	0	None	-223	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	461	3	0	4	4.1	O=C1C2CC=CCC2C(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
	CHEMBL239899	90755	0	None	-223	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	461	3	0	4	4.1	O=C1C2CC=CCC2C(=O)N1C1CCC(N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2007.07.029
	10020040	99493	0	None	-72	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	338	4	1	4	3.6	CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL28651	99493	0	None	-72	3	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	338	4	1	4	3.6	CSc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	136118653	92608	0	None	-6	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442267	92608	0	None	-6	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	155544811	175967	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4567345	175967	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4597228	175967	0	None	-5	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmc.2019.06.028
	60165411	74992	0	None	-93	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	381	7	0	7	3.3	O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037529	74992	0	None	-93	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	381	7	0	7	3.3	O=C(CCCCN1CCN(c2ncccn2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	71460454	80938	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	411	9	2	5	2.9	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(NC(C)=O)c2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159312	80938	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	411	9	2	5	2.9	CCOc1ccccc1C(=O)NC1CCN(CCOc2cccc(NC(C)=O)c2)C1	10.1016/j.ejmech.2012.07.043
	24768522	142032	0	None	2	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL389110	142032	0	None	2	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	12741423	106568	10	None	-120	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	CHEMBL315684	106568	10	None	-120	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	261	6	0	2	3.7	CCCN(CCC)[C@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	56852956	111538	1	None	-87	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289656	111538	1	None	-87	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	44517733	193532	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	431	7	3	5	1.6	COc1ccccc1N1CCN(C(=N)NCCNS(=O)(=O)c2cccc(C)c2)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL550740	193532	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	431	7	3	5	1.6	COc1ccccc1N1CCN(C(=N)NCCNS(=O)(=O)c2cccc(C)c2)CC1	10.1016/j.bmcl.2009.06.038
	162648426	179370	0	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	373	6	0	3	4.6	Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4746695	179370	0	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	373	6	0	3	4.6	Fc1ccc(CCCCN2C3CCC2CN(c2ccc(Cl)cn2)C3)cc1	10.1016/j.bmc.2020.115943
	168299277	192084	0	None	281	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	404	8	0	5	4.2	CCOCC(Oc1c(C)cccc1Cl)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
	CHEMBL5219333	192084	0	None	281	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	404	8	0	5	4.2	CCOCC(Oc1c(C)cccc1Cl)N1CCN(c2ccccc2OC)CC1	10.1016/j.bmcl.2021.128275
	44460738	104961	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	291	3	0	3	2.9	CN1CCCN(CCn2ccc3ccc(Cl)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL312049	104961	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	291	3	0	3	2.9	CN1CCCN(CCn2ccc3ccc(Cl)cc32)CC1	10.1016/s0960-894x(02)00438-9
	76332579	105781	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121423	105781	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139019	105781	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4cccc5ccccc45)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	145976618	163216	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	8	1	4	4.7	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4205806	163216	0	None	8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	8	1	4	4.7	CC(COc1ccccc1-c1ccccc1)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	90654836	112184	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233667	112184	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304308	112184	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	464	9	0	5	3.8	COc1ccccc1N1CCN(CCCCCN2C(=O)N(C)C(=O)C2(C)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	155557134	173955	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	493	10	0	5	5.1	CCOc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4555890	173955	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	493	10	0	5	5.1	CCOc1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
	11186985	123315	0	None	-11	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL362540	123315	0	None	-11	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	307	6	0	1	5.3	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	134141985	146631	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3927929	146631	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	432	6	0	6	4.4	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	66801673	111569	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289969	111569	0	None	8	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	66801251	111615	0	None	-13	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	507	7	1	6	5.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3290013	111615	0	None	-13	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	507	7	1	6	5.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	122178704	120843	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581249	120843	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	44401106	123795	0	None	-52	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL363581	123795	0	None	-52	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	76284452	104513	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	492	11	1	6	3.7	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113594	104513	0	None	16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	492	11	1	6	3.7	COc1ccc(-c2ccccc2N2CCN(CCOCCC(=O)NCc3ccc(F)nc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	46204423	124030	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640570	124030	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
	46204423	124030	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640570	124030	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	259	3	1	2	3.4	Clc1ccccc1-c1cccc(OC2CNC2)c1	nan
	72550200	113564	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(F)c2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326980	113564	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(F)c2)CC1	10.1016/j.bmc.2014.07.026
	72550423	113565	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326981	113565	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.07.026
	25107651	187117	0	None	-4	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	CHEMBL495321	187117	0	None	-4	3	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	44448054	94334	0	None	-6	6	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL253318	94334	0	None	-6	6	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	56852956	111538	1	None	-87	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289656	111538	1	None	-87	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT7 receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	44404394	132281	0	None	-30	7	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	CHEMBL370128	132281	0	None	-30	7	Human	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligandIn vitro binding affinity towards cloned human 5-HT7 receptor using [3H]5-carboximidotryptamine as radioligand	ChEMBL	443	4	1	5	3.5	COc1ccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)cc1N1CCN(C)CC1	10.1016/j.bmcl.2005.07.024
	168290061	190730	0	None	-69	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	424	8	3	8	2.7	Nc1nc(N)nc(NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5191557	190730	0	None	-69	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	424	8	3	8	2.7	Nc1nc(N)nc(NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.ejmech.2021.113931
	162643558	183024	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4777499	183024	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4802310	183024	0	None	-8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	2	5	3.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	127026119	137197	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	8	1	5	2.7	COc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759120	137197	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	8	1	5	2.7	COc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	155562834	174624	0	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	450	8	0	5	4.1	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4571077	174624	0	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	450	8	0	5	4.1	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2019.06.029
	72198011	89401	0	None	-158	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL2377591	89401	0	None	-158	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	72198011	89401	0	None	-158	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
	CHEMBL2377591	89401	0	None	-158	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	498	8	2	4	5.2	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
	13069622	120091	0	None	-31	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360999	120091	0	None	-31	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546120	120091	0	None	-31	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	410	7	0	8	1.4	Cn1c(=O)c2c(ncn2CCCCCN2CCN(c3ccccc3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	168276829	189522	0	None	-32	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5Cl)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5173329	189522	0	None	-32	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5Cl)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	117209918	185818	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	185818	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	155534153	175666	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4469860	175666	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4594878	175666	0	None	-120	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	366	4	2	5	3.4	CCc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	117209918	185818	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	185818	1	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	168279625	190403	0	None	-66	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	433	5	0	6	3.5	O=c1n(Cc2ccc(CN3CCN(c4cccc(Cl)c4)CC3)cc2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5186688	190403	0	None	-66	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	433	5	0	6	3.5	O=c1n(Cc2ccc(CN3CCN(c4cccc(Cl)c4)CC3)cc2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	71461049	82548	0	None	-204	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181187	82548	0	None	-204	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
	118626208	164990	0	None	-57	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4241830	164990	0	None	-57	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	5640104	117423	11	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	429	4	1	5	3.4	NC(=O)C1CCN(c2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)CC1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403342	117423	11	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	429	4	1	5	3.4	NC(=O)C1CCN(c2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)CC1	10.1016/j.bmcl.2015.03.049
	74538690	142520	0	None	10	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	511	10	1	4	5.2	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3895172	142520	0	None	10	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	511	10	1	4	5.2	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	164625711	185740	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4874914	185740	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	481	7	0	5	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2021.128028
	155535827	171541	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	450	6	1	2	6.5	Fc1cccc(-c2cc(F)ccc2OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.bmcl.2019.126769
	CHEMBL4472767	171541	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	450	6	1	2	6.5	Fc1cccc(-c2cc(F)ccc2OCCN2CCC(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1016/j.bmcl.2019.126769
	11278059	56705	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	302	3	1	2	4.2	Cc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644275	56705	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	302	3	1	2	4.2	Cc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	44439393	91363	0	None	2754	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241279	91363	0	None	2754	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	308	3	2	2	4.3	CSc1ccccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	44421337	137586	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assayDisplacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assay	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL376662	137586	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assayDisplacement of [3H]LSD from rat cloned 5HT7 receptor incubated for 60 mins by competitive binding assay	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1016/j.ejmech.2020.112437
	44421337	137586	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	CHEMBL376662	137586	0	None	7	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	437	8	1	5	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3c(OC)cccc32)CC1	10.1021/jm049702f
	44401105	69218	0	None	-3	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193435	69218	0	None	-3	9	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
	132547277	141602	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3883542	141602	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	424	7	0	5	4.4	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
	44324640	205679	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL94017	205679	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	281	3	2	4	3.0	COc1cccc(-c2cccc(NC3=NCCN3)c2C)c1	10.1016/s0960-894x(02)00925-3
	60165535	74985	0	None	-6	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	322	5	0	3	4.7	c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
	CHEMBL2037522	74985	0	None	-6	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	322	5	0	3	4.7	c1ccc2c(c1)CCN(CCCCc1nc3ccccc3s1)C2	10.1016/j.ejmech.2012.03.042
	162661940	181287	0	None	12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4778946	181287	0	None	12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	118728523	117202	0	None	-5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401486	117202	0	None	-5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	410	7	0	5	4.0	O=c1c2ccccc2ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	42625269	186216	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	292	3	0	2	2.6	O=C1Cc2ccccc2N1CCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL489256	186216	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	292	3	0	2	2.6	O=C1Cc2ccccc2N1CCN1CCc2ccccc2C1	10.1021/jm8014553
	44439388	91327	0	None	7	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	3	1	3	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL241082	91327	0	None	7	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	3	1	3	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
	71450550	83379	0	None	-7	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205836	83379	0	None	-7	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	1355	1972	82	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
	142	1972	82	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
	CHEMBL478	1972	82	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
	DB12110	1972	82	None	-21	16	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm3003679
	57401516	68042	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	7	1	5	3.0	CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL1916746	68042	0	None	-1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	7	1	5	3.0	CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	156009734	176582	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	393	5	2	4	3.7	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4634426	176582	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	393	5	2	4	3.7	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(N)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	9821832	125922	0	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C\CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL365201	125922	0	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C\CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	162671253	183166	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4792933	183166	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	CHEMBL4803811	183166	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	CCC(C)c1ccc(NC(=O)CCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2020.112437
	168286403	191138	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5197377	191138	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	501	6	0	7	4.6	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	43229249	140273	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818989	140273	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	57402951	70109	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	6	0	5	5.1	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL1946258	70109	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	413	6	0	5	5.1	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	11261423	141855	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	445	8	2	4	4.4	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL388970	141855	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	445	8	2	4	4.4	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	118728507	117188	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	5	3.7	Cc1sc2nc(CCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401470	117188	0	None	-9	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	1	5	3.7	Cc1sc2nc(CCCCN3CCN(c4ccccc4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	43229249	140273	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818989	140273	1	None	-91	8	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	44393074	63931	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL180946	63931	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	C[C@@H](Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	137644790	157511	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4086211	157511	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	162664377	181606	0	None	75	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	533	9	1	6	6.3	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4782879	181606	0	None	75	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	533	9	1	6	6.3	COc1ccc(-c2ccccc2C2CCN(C[C@@H](O)COc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	156012551	176753	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	470	8	0	5	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4637294	176753	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	470	8	0	5	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	138691321	173937	0	None	18	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2c(F)cc(I)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4555349	173937	0	None	18	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2c(F)cc(I)cc12	10.1016/j.ejmech.2019.03.017
	127039754	136146	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1039/C5MD00166H
	CHEMBL3740302	136146	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1039/C5MD00166H
	164619290	185213	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	463	7	0	5	4.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4866981	185213	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	463	7	0	5	4.0	O=C1c2ccccc2S(=O)(=O)N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.bmcl.2021.128028
	57391624	71210	0	None	3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1949972	71210	0	None	3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1963102	71210	0	None	3	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cccc2ccccc12	10.1016/j.bmc.2011.12.039
	11404955	56716	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	336	3	0	2	4.8	CN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644488	56716	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	336	3	0	2	4.8	CN1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	44439391	144574	0	None	52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	3	2	4	3.3	COc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2007.01.093
	CHEMBL391190	144574	0	None	52	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	336	3	2	4	3.3	COc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2007.01.093
	118709752	113030	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	362	8	0	2	4.6	O=C1Cc2ccccc2N1CCCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL3321793	113030	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	362	8	0	2	4.6	O=C1Cc2ccccc2N1CCCCCCCN1CCc2ccccc2C1	10.1021/jm500880c
	11463465	66529	0	None	-7	2	Rat	7.4	pKi	=	7.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C/CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL186334	66529	0	None	-7	2	Rat	7.4	pKi	=	7.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	391	6	0	5	2.7	COc1ccccc1N1CCN(C/C=C/CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	10807321	98699	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	343	1	2	3	4.5	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c1-3	10.1021/jm0108505
	CHEMBL281273	98699	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	343	1	2	3	4.5	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(O)cccc2O)c1-3	10.1021/jm0108505
	118713587	113859	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	367	6	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331255	113859	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	367	6	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	134151729	152899	0	None	5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3979307	152899	0	None	5	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	455	10	1	3	5.7	C[C@H]1CN(c2ccccc2-c2ccccc2)CCN1CCCCCC(=O)NCc1ccccc1	10.1016/j.ejmech.2016.05.005
	72550196	113563	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326979	113563	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	475	10	1	4	5.1	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2014.07.026
	155524374	170343	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4455118	170343	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2016.06.080
	11429236	124885	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	390	8	1	5	2.4	COc1ccc(S(=O)(=O)NCCCN2CCc3cc(OC)ccc3C2)cc1	10.1021/jm049743b
	CHEMBL364557	124885	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	390	8	1	5	2.4	COc1ccc(S(=O)(=O)NCCCN2CCc3cc(OC)ccc3C2)cc1	10.1021/jm049743b
	57395597	68052	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	410	7	1	4	3.6	COc1cccc2c1CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1016/j.bmc.2011.09.044
	CHEMBL1917330	68052	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	410	7	1	4	3.6	COc1cccc2c1CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1016/j.bmc.2011.09.044
	145964159	163766	0	None	-77	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212435	163766	0	None	-77	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	44439410	146744	0	None	5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	280	4	1	2	3.5	CN(/C=N/c1ccc2c(c1)C(O)CC2)Cc1ccccc1	10.1016/j.bmcl.2007.01.093
	CHEMBL392888	146744	0	None	5	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	280	4	1	2	3.5	CN(/C=N/c1ccc2c(c1)C(O)CC2)Cc1ccccc1	10.1016/j.bmcl.2007.01.093
	44439407	166850	0	None	-11	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	424	8	0	4	5.9	CCCCSC1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL429644	166850	0	None	-11	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	424	8	0	4	5.9	CCCCSC1CCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	71459604	83365	0	None	-6	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205811	83365	0	None	-6	14	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	145979626	165977	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	454	6	2	5	1.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(=O)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4279397	165977	0	None	1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	454	6	2	5	1.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(=O)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	118736371	118425	0	None	-9	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	6	0	9	2.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423335	118425	0	None	-9	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	6	0	9	2.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
	118724643	120078	0	None	-8	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361002	120078	0	None	-8	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3545933	120078	0	None	-8	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	353	4	0	7	0.9	Cn1c(=O)c2c(ncn2CCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	122483213	137552	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764178	137552	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765841	137552	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	135367399	163272	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4206411	163272	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	118736370	118424	0	None	-50	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	7	0	9	2.3	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423334	118424	0	None	-50	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	483	7	0	9	2.3	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccc(Cl)cc5)CC4)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	122483213	137552	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764178	137552	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765841	137552	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	27620	140274	13	None	-158	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818994	140274	13	None	-158	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	11209976	122644	0	None	1	3	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	CHEMBL361287	122644	0	None	1	3	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	339	7	0	3	4.8	CCCN(CCC)[C@@H]1COc2c(cccc2-c2ccccc2OC)C1	10.1021/jm0498102
	71455894	83374	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205827	83374	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	71455894	83374	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
	CHEMBL2205827	83374	0	None	-3	12	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
	135398745	2858	108	None	-95	66	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	47	2858	108	None	-95	66	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	CHEMBL715	2858	108	None	-95	66	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	DB00334	2858	108	None	-95	66	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
	162644116	183028	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4778021	183028	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4802344	183028	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	411	10	1	5	3.3	COc1ccccc1CNC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	155552054	173429	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)c1	10.1016/j.bmcl.2019.06.029
	CHEMBL4542754	173429	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)c1	10.1016/j.bmcl.2019.06.029
	155534312	171341	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	445	8	1	4	5.8	O=c1[nH]c(CCCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4469984	171341	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	445	8	1	4	5.8	O=c1[nH]c(CCCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	135367399	163272	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4206411	163272	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	136116062	97218	0	None	-10	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL271253	97218	0	None	-10	4	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	CC1NC(NCC(F)F)=Nc2c(Cl)ccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	44391586	165780	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
	CHEMBL427326	165780	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1ccc2c(c1)C[C@H](N(C)C)CO2	10.1016/j.bmcl.2004.11.013
	44395817	66451	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	441	6	0	5	3.8	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL185988	66451	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	441	6	0	5	3.8	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1	10.1016/j.bmcl.2004.09.029
	44424670	85284	0	None	-61	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	446	6	1	8	1.0	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	CHEMBL228940	85284	0	None	-61	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	446	6	1	8	1.0	Cn1c(=O)c2c([nH]c(=O)n2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2007.05.017
	135367821	163329	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207073	163329	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	137636384	155398	0	None	-741	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	356	4	0	4	2.5	CN(C)CC1=CC2=CN(S(=O)(=O)c3ccccc3)C3=CC=CC(O1)C23	10.1021/acsmedchemlett.6b00482
	CHEMBL4061189	155398	0	None	-741	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	356	4	0	4	2.5	CN(C)CC1=CC2=CN(S(=O)(=O)c3ccccc3)C3=CC=CC(O1)C23	10.1021/acsmedchemlett.6b00482
	11166042	165805	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2019.111705
	CHEMBL427518	165805	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	419	9	1	6	2.2	COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.ejmech.2019.111705
	44461069	203873	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	377	5	0	3	4.1	CC(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81488	203873	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	377	5	0	3	4.1	CC(C)CN1CCCN(CCn2ccc3ccc(Br)cc32)CC1	10.1016/s0960-894x(02)00438-9
	122181338	121353	0	None	-2	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	466	6	1	4	4.0	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590090	121353	0	None	-2	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	466	6	1	4	4.0	O=C1NC2(CCCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	137650705	156680	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4076408	156680	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	137645926	157011	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4080398	157011	0	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2017.04.046
	57395599	68079	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917357	68079	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	156016366	177055	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	458	10	1	6	4.0	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
	CHEMBL4641296	177055	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	458	10	1	6	4.0	O=S(=O)(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
	134130247	154026	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3890153	154026	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3991291	154026	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	44374233	51238	2	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	CHEMBL158285	51238	2	None	3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	118736373	118427	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	545	7	0	9	3.6	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423337	118427	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	545	7	0	9	3.6	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	135398737	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	38	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	722	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	CHEMBL42	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	DB00363	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/np500893h
	44437334	149953	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL395444	149953	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	694	18	0	9	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	44266178	97901	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	403	4	0	3	3.1	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL275258	97901	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	403	4	0	3	3.1	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3ccccc32)CC1	10.1016/s0960-894x(03)00077-5
	134130247	154026	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3890153	154026	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3991291	154026	0	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	308	4	0	3	4.3	c1ccc2c(c1)CCN(CCCc1nc3ccccc3s1)C2	10.1016/j.bmc.2016.09.019
	72549986	113311	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	457	10	1	4	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3325464	113311	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	457	10	1	4	5.0	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	53316914	56718	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	364	4	0	2	5.6	CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644490	56718	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	364	4	0	2	5.6	CC(C)N1CCc2c(c(-c3ccc(Cl)cc3)cn2Cc2ccccc2)C1	10.1016/j.bmcl.2010.11.078
	9927441	205652	0	None	-1096	10	Human	5.4	pKi	=	5.4	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1021/jm010943m
	CHEMBL93868	205652	0	None	-1096	10	Human	5.4	pKi	=	5.4	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1021/jm010943m
	17055181	161890	2	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	409	7	1	2	6.2	Cc1ccc(COc2ccc(Br)cc2CNC(C)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4166667	161890	2	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	409	7	1	2	6.2	Cc1ccc(COc2ccc(Br)cc2CNC(C)c2ccccc2)cc1	10.1016/j.ejmech.2018.04.010
	155547436	172990	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1	10.1016/j.bmcl.2019.06.029
	CHEMBL4532741	172990	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	471	9	0	5	4.8	COc1cccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1	10.1016/j.bmcl.2019.06.029
	168278783	190126	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5182578	190126	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5cccc(Cl)c5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	135367821	163329	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207073	163329	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	155521504	176011	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
	CHEMBL4451939	176011	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
	CHEMBL4597600	176011	0	None	-416	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	432	4	2	6	4.3	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.ejmech.2019.06.001
	164618208	184793	0	None	-371	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	467	6	0	5	3.7	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4860626	184793	0	None	-371	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	467	6	0	5	3.7	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	3132842	162425	9	None	-10	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	411	9	1	4	5.4	CCC1(C)CC(CCNCc2ccc(OC)c(OC)c2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
	CHEMBL4175296	162425	9	None	-10	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	411	9	1	4	5.4	CCC1(C)CC(CCNCc2ccc(OC)c(OC)c2)(c2ccc(C)cc2)CCO1	10.1016/j.ejmech.2018.04.010
	155516282	169491	0	None	-20	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1ccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)cc1	10.1016/j.bmcl.2019.06.029
	CHEMBL4443185	169491	0	None	-20	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	443	9	0	4	5.2	COc1ccc(N2CCN(CCCCCCN3C(=O)c4cccc5cccc3c45)CC2)cc1	10.1016/j.bmcl.2019.06.029
	122181343	121358	0	None	-17	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	528	7	1	4	5.3	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590095	121358	0	None	-17	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	528	7	1	4	5.3	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	122483292	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764335	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765876	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	57392108	68076	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917354	68076	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	145971561	163946	0	None	7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	444	4	1	4	3.7	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)c(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4214709	163946	0	None	7	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	444	4	1	4	3.7	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccc(Cl)c(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
	122483292	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764335	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765876	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	56945046	111555	0	None	-6	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	7	1	6	4.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3289955	111555	0	None	-6	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	500	7	1	6	4.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	122178706	120845	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581251	120845	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	42618264	180887	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	394	8	1	5	3.3	COc1ccccc1N1CCN(CCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL476464	180887	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	394	8	1	5	3.3	COc1ccccc1N1CCN(CCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL5090557	213486	0	None	-54	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccccc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	162665588	181804	0	None	-85	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
	CHEMBL4785434	181804	0	None	-85	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
	122483292	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764335	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765876	137570	0	None	-1	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	10610641	98449	0	None	-2	5	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9911433
	CHEMBL27940	98449	0	None	-2	5	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9911433
	11466615	137510	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)C(NC(=O)CCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	CHEMBL376531	137510	0	None	2	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)C(NC(=O)CCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	135458428	154982	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	255	3	2	4	2.2	COc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
	CHEMBL404248	154982	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	255	3	2	4	2.2	COc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
	66801701	158770	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	471	8	2	3	5.3	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4099997	158770	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	471	8	2	3	5.3	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c(C)[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	155521010	170015	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	572	9	1	6	5.4	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4450652	170015	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	572	9	1	6	5.4	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	90644075	111574	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	8	1	7	3.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289973	111574	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	484	8	1	7	3.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	46206026	124073	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
	CHEMBL3640611	124073	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
	46206026	124073	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
	CHEMBL3640611	124073	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	2	1	1	4.5	Cc1cc(-c2ccc(Cl)cc2C2CCNC2)ccc1F	nan
	2927683	161641	9	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	8	1	2	6.0	CC(NCCC(Cc1ccccc1)c1ccco1)c1ccc(Cl)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4162688	161641	9	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	8	1	2	6.0	CC(NCCC(Cc1ccccc1)c1ccco1)c1ccc(Cl)cc1	10.1016/j.ejmech.2018.04.010
	146025727	171109	0	None	-141	27	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171109	0	None	-141	27	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	155536152	171563	0	None	-29	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	368	4	1	7	2.1	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4473083	171563	0	None	-29	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	368	4	1	7	2.1	CN1CCN(c2nc(N)nc(COc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	57396855	71115	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949969	71115	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1962400	71115	0	None	-6	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc2cccnc2c1	10.1016/j.bmc.2011.12.039
	118736375	118429	0	None	-14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	477	6	0	9	2.2	Cc1cccc(N2CCN(CCCCn3c(C)cn4c5c(=O)n(C)c(=O)n(C)c5nc34)CC2)c1C	10.1016/j.ejmech.2015.04.046
	CHEMBL3423339	118429	0	None	-14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	477	6	0	9	2.2	Cc1cccc(N2CCN(CCCCn3c(C)cn4c5c(=O)n(C)c(=O)n(C)c5nc34)CC2)c1C	10.1016/j.ejmech.2015.04.046
	71461050	82550	0	None	-123	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181189	82550	0	None	-123	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT7 by Cerep protocol based assayBinding affinity to human 5HT7 by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
	10971846	50207	0	None	-1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	420	8	1	4	5.0	O=C(CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL157362	50207	0	None	-1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	420	8	1	4	5.0	O=C(CCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccccc1O	10.1021/jm020994z
	139488518	169419	0	None	14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2cccc(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4442337	169419	0	None	14	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	229	2	1	2	3.2	CCn1cncc1-c1c[nH]c2cccc(F)c12	10.1016/j.ejmech.2019.03.017
	135367936	163910	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4214171	163910	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	156017609	177317	0	None	-19	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	464	9	1	6	4.9	O=C1CCc2cc(OCCCCCCN3CCN(c4nsc5ccccc45)CC3)ccc2N1	10.1016/j.bmc.2020.115459
	CHEMBL4644906	177317	0	None	-19	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	464	9	1	6	4.9	O=C1CCc2cc(OCCCCCCN3CCN(c4nsc5ccccc45)CC3)ccc2N1	10.1016/j.bmc.2020.115459
	155519102	169776	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4447416	169776	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	155519102	169776	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4447416	169776	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	155519102	169776	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	CHEMBL4447416	169776	0	None	-371	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	1220	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
	31	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
	7	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
	CHEMBL56	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2016.06.080
	1220	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
	31	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
	7	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
	CHEMBL56	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2016.12.039
	1220	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
	31	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
	7	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
	CHEMBL56	186	46	None	-199	45	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2015.02.042
	145946527	166998	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
	CHEMBL4217761	166998	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
	CHEMBL4300609	166998	0	None	-10	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	382	10	0	4	3.6	Cc1cccc(OCCOCCN2CCN(CCc3ccccc3)CC2)c1C	10.1016/j.bmcl.2018.04.059
	134155651	150586	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	329	4	0	2	5.2	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3959382	150586	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	329	4	0	2	5.2	COc1ccccc1-c1cc(CN2CCC(C)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	25107652	186819	0	None	-20	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	CHEMBL493709	186819	0	None	-20	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	142601325	185277	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185277	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	135367936	163910	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4214171	163910	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	137655411	158198	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4093971	158198	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
	127026147	137201	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	417	8	2	5	3.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(N)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759161	137201	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	417	8	2	5	3.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(N)cc2)CC1	10.1016/j.ejmech.2015.11.040
	156014041	176624	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4635363	176624	0	None	-2	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	443	8	0	4	4.1	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2020.115459
	90656700	112174	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3259846	112174	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304188	112174	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	417	9	1	4	5.4	CN(CCCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	90656687	110482	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	402	8	1	5	2.7	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262417	110482	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	402	8	1	5	2.7	CN(CCCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	145	140	48	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
	1832	140	48	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
	CHEMBL7257	140	48	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
	DB14010	140	48	None	-4	30	Rat	7.4	pKi	=	7.4	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm030826m
	49850570	56163	0	None	-251	9	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1632220	56163	0	None	-251	9	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	44343212	9730	0	None	50	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL114012	9730	0	None	50	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor 7(a) (human cloned receptor in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	135398737	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	38	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	722	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	CHEMBL42	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	DB00363	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2010.03.012
	9934284	89851	0	None	-100	10	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238520	89851	0	None	-100	10	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	44439165	145208	0	None	-15	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL391661	145208	0	None	-15	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	11475386	122104	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	410	7	1	4	3.6	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1021/jm049743b
	CHEMBL360382	122104	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	410	7	1	4	3.6	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1cccc3ccccc13)C2	10.1021/jm049743b
	156022135	177634	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4649788	177634	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	4223	3917	88	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	6918314	3917	88	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	7427	3917	88	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	CHEMBL439849	3917	88	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	DB06684	3917	88	None	-81	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmcl.2019.126703
	76332583	105921	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121439	105921	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139517	105921	0	None	-1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	319	3	0	3	3.7	Cc1ccccc1-n1cc(CN2CCN(C)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	71453157	80745	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	3	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158038	80745	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	418	7	1	3	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	162676059	183194	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4796573	183194	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804095	183194	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	4.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	142601325	185277	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185277	0	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	90654679	109598	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235751	109598	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.ejmech.2014.03.005
	156017397	177113	0	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	420	7	1	4	5.0	CCCC(=O)Nc1ccc2c(c1)-c1c(OCC3CC3)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL4642034	177113	0	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	420	7	1	4	5.0	CCCC(=O)Nc1ccc2c(c1)-c1c(OCC3CC3)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	16117151	59756	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1642882	59756	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1739102	59756	0	None	-3981	7	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	127026052	137015	0	None	-23	19	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3754496	137015	0	None	-23	19	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
	10715998	44958	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL152595	44958	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	10596321	205721	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL94261	205721	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	11281062	119139	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	401	6	0	4	4.0	COc1ccccc1N1CCN(CCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	CHEMBL346906	119139	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	401	6	0	4	4.0	COc1ccccc1N1CCN(CCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	147653864	170985	0	None	-19	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4464697	170985	0	None	-19	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	11168182	3465	18	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	264	3465	18	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	CHEMBL1181770	3465	18	None	-630	13	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	276	3444	45	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
	5312149	3444	45	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
	CHEMBL431298	3444	45	None	-100	13	Human	5.4	pKi	=	5.4	Binding	Compound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CTCompound was tested for its binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1021/jm980532e
	276	3444	45	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
	5312149	3444	45	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
	CHEMBL431298	3444	45	None	-100	13	Human	5.4	pKi	=	5.4	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/s0960-894x(02)00172-5
	44393007	65946	0	None	120	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cncc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL184789	65946	0	None	120	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	351	8	2	4	4.9	C[C@H](Nc1cncc(NCCOc2ccc(F)cc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393229	66349	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL185512	66349	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	335	7	2	3	5.0	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ccn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393004	121647	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cncc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL359725	121647	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	333	8	2	4	4.7	C[C@H](Nc1cncc(NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	5	139	66	None	-3	55	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	5202	139	66	None	-3	55	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	CHEMBL39	139	66	None	-3	55	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	DB08839	139	66	None	-3	55	Human	8.4	pKi	=	8.4	Binding	Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptorBinding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	145965054	163726	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	472	7	2	4	3.8	CNC(=O)CN1c2ccccc2C2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC21	10.1021/acs.jmedchem.7b01898
	CHEMBL4211987	163726	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	472	7	2	4	3.8	CNC(=O)CN1c2ccccc2C2CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC21	10.1021/acs.jmedchem.7b01898
	9956365	193836	0	None	34	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm030030n
	CHEMBL553794	193836	0	None	34	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	470	7	2	4	4.1	CNC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm030030n
	76320705	103051	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1C=CC=C(C#N)[C@@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
	CHEMBL3085301	103051	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	352	1	0	2	5.2	CC1C=CC=C(C#N)[C@@H]1c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm049743b
	4106	2456	16	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	5358812	2456	16	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	89	2456	16	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	CHEMBL93240	2456	16	None	-2	34	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm030030n
	127024951	137102	0	None	51	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(Cl)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758286	137102	0	None	51	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	4	4.8	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cccc(Cl)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	127026131	137212	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cc(F)ccc2F)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759233	137212	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cc(F)ccc2F)C3)c1	10.1016/j.ejmech.2015.11.040
	118626101	165160	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4245997	165160	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626142	165256	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4248491	165256	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	71453281	81016	0	None	6	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159485	81016	0	None	6	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)C1	10.1016/j.ejmech.2012.07.043
	71451460	81019	0	None	9	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159488	81019	0	None	9	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	462	8	1	5	4.5	O=S(=O)(N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	139488606	170180	1	None	147	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(I)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4452569	170180	1	None	147	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	355	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(I)c(F)c12	10.1016/j.ejmech.2019.03.017
	54758295	65654	0	None	13	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	378	7	1	4	3.7	CCC1(CCCCN2CCN(c3ccccn3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL1836789	65654	0	None	13	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	378	7	1	4	3.7	CCC1(CCCCN2CCN(c3ccccn3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	118706732	120003	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3310713	120003	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3545445	120003	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	44374233	51238	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL158285	51238	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmcl.2003.11.050
	44374233	51238	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	CHEMBL158285	51238	2	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor	ChEMBL	260	4	0	3	2.5	CN(C)CCSc1cccc(Br)n1	10.1016/j.bmc.2010.01.035
	118706285	112376	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310113	112376	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	118706301	120014	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310122	120014	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545473	120014	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	66801455	111564	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	8	2.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3289964	111564	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	470	8	1	8	2.8	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	66801062	111613	0	None	-4	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3290011	111613	0	None	-4	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	473	7	1	6	4.7	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	11282296	142771	0	None	-1	5	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL389718	142771	0	None	-1	5	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	135458427	170977	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	283	4	2	4	3.0	CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
	CHEMBL446459	170977	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	283	4	2	4	3.0	CC(C)Oc1cccc2c1N=C(NCC(F)F)NC2C	10.1016/j.bmcl.2007.10.078
	118524962	177085	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4641654	177085	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)C1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	11694810	120015	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3310123	120015	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545474	120015	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	10707685	162391	0	None	6	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@]3(C)O	10.1021/jm9911433
	CHEMBL417473	162391	0	None	6	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	277	0	1	2	3.0	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@]3(C)O	10.1021/jm9911433
	11694810	120015	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120015	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120015	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	66801225	111612	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
	CHEMBL3290010	111612	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12	10.1021/jm401895u
	2389	3267	114	None	-9	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	5073	3267	114	None	-9	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	96	3267	114	None	-9	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	CHEMBL85	3267	114	None	-9	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	DB00734	3267	114	None	-9	68	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
	44388858	61153	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL177064	61153	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2009.02.008
	11566558	158897	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	354	6	1	3	4.6	CCC1(CCCCN2CCc3sccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL410128	158897	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	354	6	1	3	4.6	CCC1(CCCCN2CCc3sccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
	109018769	174706	1	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	337	7	1	3	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
	CHEMBL4572955	174706	1	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	337	7	1	3	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)NCc1ccccc1	10.1016/j.bmcl.2016.06.080
	56944191	111597	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	483	8	1	5	4.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289996	111597	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	483	8	1	5	4.7	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	46206347	124026	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	CHEMBL3640566	124026	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	46206347	124026	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	CHEMBL3640566	124026	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	4	1	3	3.4	COc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	22449331	106439	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	360	5	1	2	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL314830	106439	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	360	5	1	2	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	44266156	97938	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	382	5	0	3	3.8	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL275451	97938	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	382	5	0	3	3.8	O=C1c2ccccc2CCCN1CCN1CCC(Oc2ccc(F)cc2)CC1	10.1016/s0960-894x(03)00077-5
	11662592	71984	0	None	-3	9	Human	8.4	pKi	=	8.4	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	CHEMBL198463	71984	0	None	-3	9	Human	8.4	pKi	=	8.4	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	76321735	105902	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL3121424	105902	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
	CHEMBL3139441	105902	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2019.111705
	76321735	105902	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121424	105902	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139441	105902	0	None	15	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	447	5	0	4	6.1	COc1ccccc1N1CCN(Cc2cn(-c3cccc4ccccc34)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	134156520	153569	0	None	8	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	1	5	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3985152	153569	0	None	8	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	501	13	1	5	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	156013673	176677	0	None	10	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4636148	176677	0	None	10	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	293	1	2	2	2.9	CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3	10.1016/j.bmc.2020.115578
	66800916	111562	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	518	8	1	7	4.8	Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	CHEMBL3289962	111562	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	518	8	1	7	4.8	Cc1c(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)sc2ccc(F)cc12	10.1021/jm401895u
	44388858	61153	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL177064	61153	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2005.05.059
	44388858	61153	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2007.03.054
	CHEMBL177064	61153	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	361	5	0	4	4.1	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C)c2)CC1	10.1016/j.bmcl.2007.03.054
	24854043	95443	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
	CHEMBL259215	95443	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
	10971401	102210	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	1	2	5.5	Cc1ccc(C2=CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
	CHEMBL304731	102210	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	400	6	1	2	5.5	Cc1ccc(C2=CCN(CCCCC34CCCc5cccc(c53)NC4=O)CC2)cc1	10.1021/jm0104264
	164609172	183815	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4845947	183815	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	162674129	182621	0	None	-10	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4795995	182621	0	None	-10	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2s1	10.1016/j.ejmech.2020.112149
	164609172	183815	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4845947	183815	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	378	6	1	5	2.8	O=C1CCc2cc(C(=O)CCCN3CCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	44437331	90518	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239530	90518	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	135339817	180892	0	None	-7	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	CHEMBL4764679	180892	0	None	-7	8	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	11687730	120061	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343668	120061	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545816	120061	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	127024950	137253	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	412	8	1	6	2.1	Cn1cc(S(=O)(=O)NC2CN(CCOc3ccccc3-c3ccccc3)C2)cn1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759558	137253	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	412	8	1	6	2.1	Cn1cc(S(=O)(=O)NC2CN(CCOc3ccccc3-c3ccccc3)C2)cn1	10.1016/j.ejmech.2015.11.040
	118731360	117680	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	544	9	0	4	5.5	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409043	117680	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	544	9	0	4	5.5	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	162668650	182081	0	None	-13	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4789085	182081	0	None	-13	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	57396419	71183	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1949976	71183	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1962961	71183	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cnc2ccccc2c1)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	82187974	112171	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262406	112171	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304139	112171	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	296	5	1	3	3.1	Oc1cccc(CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	135398737	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	38	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	722	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	CHEMBL42	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	DB00363	942	89	None	-13	92	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	11532105	65657	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	432	6	1	2	5.8	O=C1Nc2ccc(F)cc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
	CHEMBL1836792	65657	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	432	6	1	2	5.8	O=C1Nc2ccc(F)cc2C1CCCCN1CC=C(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm200547z
	54758391	65664	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	CHEMBL1836859	65664	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	23369416	181895	2	None	-3	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL478680	181895	2	None	-3	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	366	6	1	5	2.6	COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	155512406	169063	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	449	7	1	5	5.6	O=c1[nH]c(SCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4437211	169063	0	None	25	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	449	7	1	5	5.6	O=c1[nH]c(SCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	11385992	84231	0	None	1	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL222477	84231	0	None	1	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	439	8	1	3	5.2	O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	2389	3267	114	None	-9	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	5073	3267	114	None	-9	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	96	3267	114	None	-9	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	CHEMBL85	3267	114	None	-9	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	DB00734	3267	114	None	-9	68	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2020.112709
	44324643	205496	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	311	4	2	5	3.1	COc1ccc(-c2cccc(NC3=NCCN3)c2C)c(OC)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL92856	205496	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	311	4	2	5	3.1	COc1ccc(-c2cccc(NC3=NCCN3)c2C)c(OC)c1	10.1016/s0960-894x(02)00925-3
	10596321	205721	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
	CHEMBL94261	205721	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm030030n
	156010130	176455	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	5.1	CN(C)C1CCc2c(cccc2-c2cc(Cl)cc(Cl)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4632499	176455	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	5.1	CN(C)C1CCc2c(cccc2-c2cc(Cl)cc(Cl)c2)C1	10.1016/j.bmc.2019.115262
	59752589	179236	0	None	-26	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4745055	179236	0	None	-26	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
	44439398	90768	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	5	0	5	4.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL240022	90768	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	5	0	5	4.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCC3)CC2	10.1016/j.bmcl.2007.01.093
	9950396	144578	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	4	1	4	3.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL391192	144578	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	352	4	1	4	3.4	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CC3)CC2	10.1016/j.bmcl.2007.01.093
	59752584	180903	0	None	-128	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4764808	180903	0	None	-128	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
	155519045	169747	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	446	8	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4446978	169747	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	446	8	1	5	4.7	O=c1[nH]c(CCCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	118464420	137704	0	None	-67	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770342	137704	0	None	-67	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	53361627	66281	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1812288	66281	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1852767	66281	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2011.04.060
	155545088	176073	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4528793	176073	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598089	176073	0	None	-5	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	6.0	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	72550864	113567	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326983	113567	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(Cl)c2)CC1	10.1016/j.bmc.2014.07.026
	71462066	80739	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	4.4	CC(C)c1ccccc1OCCN1CCC(CNC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158032	80739	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	386	8	1	4	4.4	CC(C)c1ccccc1OCCN1CCC(CNC(=O)c2cccs2)CC1	10.1016/j.ejmech.2012.07.043
	1353	1872	85	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	3559	1872	85	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	86	1872	85	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	CHEMBL54	1872	85	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	DB00502	1872	85	None	-263	86	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.ejmech.2018.01.002
	145975713	163379	0	None	10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207633	163379	0	None	10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.8b00828
	71451344	80736	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	3	4.4	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc3c2CCCC3)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158029	80736	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	406	7	1	3	4.4	Cc1ccccc1C(=O)NCC1CCN(CCOc2cccc3c2CCCC3)CC1	10.1016/j.ejmech.2012.07.043
	56851049	71144	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926734	71144	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962693	71144	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@H]1CCc2ccccc2O1	10.1021/jm2007886
	76328892	105920	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121429	105920	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139511	105920	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	392	4	0	4	4.8	N#Cc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	57390337	68078	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917356	68078	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	482	10	0	6	3.9	CCN(CCCCN1CCN(c2ccccc2OC)CC1)S(=O)(=O)c1ccc2ncccc2c1	10.1016/j.bmc.2011.09.044
	71462178	81000	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	7	1	4	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159469	81000	0	None	-1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	7	1	4	4.8	O=C(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	71574298	85844	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	526	8	1	5	5.1	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312936	85844	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	526	8	1	5	5.1	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
	145976158	163279	0	None	53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4206468	163279	0	None	53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	118706278	119999	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310109	119999	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545439	119999	0	None	-26	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	118706292	120010	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310117	120010	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545469	120010	0	None	-6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	118709754	113033	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	340	6	0	2	4.3	O=C1Cc2ccccc2N1CCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321796	113033	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	340	6	0	2	4.3	O=C1Cc2ccccc2N1CCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	66801116	111589	0	None	81	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	8	2.9	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3289988	111589	0	None	81	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	457	7	1	8	2.9	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	11785995	83920	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)C(NC(=O)CCCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	CHEMBL221732	83920	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc2c(c1)C(NC(=O)CCCCCN1CCN(c3ccccc3OC)CC1)CCC2	10.1021/jm049702f
	44437327	90422	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239231	90422	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	650	15	0	8	5.9	COc1ccccc1N1CCN(CCc2cccc(OCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	118713590	113863	0	None	16	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331259	113863	0	None	16	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	381	7	0	5	3.7	O=c1sc2ccccc2n1CCCCN1CCN(Cc2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	162675477	182850	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	464	6	0	4	5.4	COc1ccc(-c2ccccc2N2CCN(CC#CCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4798874	182850	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	464	6	0	4	5.4	COc1ccc(-c2ccccc2N2CCN(CC#CCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	44424653	141546	0	None	-4	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	456	8	0	10	1.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL388133	141546	0	None	-4	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	456	8	0	10	1.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	46204730	124036	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
	CHEMBL3640576	124036	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
	46204730	124036	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
	CHEMBL3640576	124036	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	273	3	1	2	3.7	Cc1cccc(-c2ccc(Cl)c(OC3CNC3)c2)c1	nan
	130442572	171332	0	None	-87	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171332	0	None	-87	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	19958507	98949	0	None	-81	5	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	320	4	1	3	3.4	CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL282829	98949	0	None	-81	5	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	320	4	1	3	3.4	CCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	46233353	200649	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	259	4	0	2	3.1	CN(C)CCSc1ccccc1Br	10.1016/j.bmc.2010.01.035
	CHEMBL610515	200649	3	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	259	4	0	2	3.1	CN(C)CCSc1ccccc1Br	10.1016/j.bmc.2010.01.035
	136118617	75881	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058416	75881	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	10267394	99910	3	None	-181	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL28997	99910	3	None	-181	4	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	310	3	1	3	3.0	Fc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	57399432	70106	0	None	-14	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	399	6	0	4	5.5	Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	CHEMBL1946254	70106	0	None	-14	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	399	6	0	4	5.5	Clc1ccc(N2CCCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	90469187	185416	0	None	-1380	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	406	3	1	6	3.1	Cc1cccc(S(=O)(=O)n2ccc3c(N4CCNCC4)nc4ccccc4c32)c1	10.1021/acs.jmedchem.1c00224
	CHEMBL4870374	185416	0	None	-1380	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	406	3	1	6	3.1	Cc1cccc(S(=O)(=O)n2ccc3c(N4CCNCC4)nc4ccccc4c32)c1	10.1021/acs.jmedchem.1c00224
	71462065	80737	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	424	7	1	3	4.7	O=C(NCC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158030	80737	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	424	7	1	3	4.7	O=C(NCC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	145976698	163382	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2Br)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207656	163382	0	None	5	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2Br)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	90654695	109579	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	422	6	1	5	2.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235732	109579	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	422	6	1	5	2.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	11048252	202472	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	7	2	3	4.3	NC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	CHEMBL70764	202472	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	429	7	2	3	4.3	NC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	168296329	191830	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	359	3	2	4	2.7	O=c1[nH]c2cccc(N3CCN(Cc4ccc5ccccc5n4)CC3)c2[nH]1	10.1016/j.ejmech.2022.114218
	CHEMBL5208347	191830	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	359	3	2	4	2.7	O=c1[nH]c2cccc(N3CCN(Cc4ccc5ccccc5n4)CC3)c2[nH]1	10.1016/j.ejmech.2022.114218
	164628177	188016	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4875079	188016	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL5029038	188016	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL5079536	212840	0	None	-60	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		Cc1c(S(=O)(=O)N[C@H]2C[C@H](C)N(CCCc3noc4cc(F)ccc34)C2)sc2ccc(Cl)cc12	10.1021/acs.jmedchem.1c00497
	56850658	71161	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926745	71161	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962804	71161	0	None	-19	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	53377324	66299	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1812290	66299	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1852853	66299	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	481	6	0	6	4.6	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.ejmech.2011.04.060
	135458672	117417	10	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	3	2	3	4.1	Cc1ccc(S(=O)(=O)N/N=C2\CCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403337	117417	10	None	-1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	387	3	2	3	4.1	Cc1ccc(S(=O)(=O)N/N=C2\CCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1016/j.bmcl.2015.03.049
	45113400	14101	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
	CHEMBL1099284	14101	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
	CHEMBL1199172	14101	2	None	-19	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	359	3	2	3	3.1	CN1CCc2[nH]c3ccc(S(=O)(=O)Nc4cccc(F)c4)cc3c2C1	10.1016/j.ejmech.2009.10.035
	138691329	170146	0	None	100	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(Cl)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4452121	170146	0	None	100	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	245	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(Cl)cc12	10.1016/j.ejmech.2019.03.017
	127040444	136245	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	402	8	1	4	3.6	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1039/C5MD00166H
	CHEMBL3741279	136245	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	402	8	1	4	3.6	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1039/C5MD00166H
	156018601	177310	0	None	9	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	414	6	1	5	3.4	C=CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4644833	177310	0	None	9	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	414	6	1	5	3.4	C=CCOc1c(OC)cc2c3c1-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	118051679	169571	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	480	9	1	7	2.8	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4444280	169571	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	480	9	1	7	2.8	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	59395105	105846	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3092755	105846	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3139187	105846	1	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	25108474	192587	0	None	-38	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL523381	192587	0	None	-38	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	44437330	151645	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396844	151645	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	706	19	0	8	7.5	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	71602692	89245	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376461	89245	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
	162651292	179632	0	None	-33	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
	CHEMBL4749824	179632	0	None	-33	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
	162666019	181708	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	9	0	6	6.4	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3Cl)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4784089	181708	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	532	9	0	6	6.4	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3Cl)CC2)cc1	10.1016/j.ejmech.2020.112395
	164628177	188016	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL4875079	188016	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL5029038	188016	0	None	-4	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	366	7	1	5	2.8	CC(=O)Nc1ccc(C(=O)CCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	155551114	176086	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4541606	176086	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598210	176086	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	431	8	0	3	5.3	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2F)CC1	10.1016/j.bmc.2019.06.028
	13091356	113026	0	None	-102	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321789	113026	0	None	-102	8	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	155529153	170825	0	None	-38	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	378	4	1	6	0.3	CC([Se]c1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4462404	170825	0	None	-38	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	378	4	1	6	0.3	CC([Se]c1ccccc1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	135367855	163819	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4213067	163819	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	60165541	74981	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	364	6	0	4	5.1	O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037518	74981	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	364	6	0	4	5.1	O=C(CCCN1CCC(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	24768523	143136	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL390015	143136	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	71727069	101919	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
	CHEMBL2401935	101919	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
	CHEMBL3039672	101919	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]5-CT from human 5HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	4	0	5	4.3	COc1ccccc1N1CCN(Cc2ccc3oc4ccccc4c(=O)c3c2)CC1	10.1016/j.bmcl.2013.05.062
	135367855	163819	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4213067	163819	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccccc1-c1noc2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	71462155	80942	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	6	1	3	4.9	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159316	80942	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	408	6	1	3	4.9	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)C1	10.1016/j.ejmech.2012.07.043
	118464427	137793	0	None	-15	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771331	137793	0	None	-15	7	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	168282819	190606	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	419	10	4	8	3.1	COc1ccccc1OCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5189520	190606	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	419	10	4	8	3.1	COc1ccccc1OCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	11142729	119215	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccc2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL347629	119215	0	None	3	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccc2)CC1)c1ccccc1O	10.1021/jm020994z
	1613	2306	44	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	205	2306	44	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	3964	2306	44	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	CHEMBL831	2306	44	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	DB00408	2306	44	None	-14	45	Rat	7.4	pKi	=	7.4	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1021/jm030030n
	24944943	102024	0	None	-17	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	CHEMBL2431038	102024	0	None	-17	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	CHEMBL3040400	102024	0	None	-17	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	122181346	121361	0	None	2	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590098	121361	0	None	2	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCCCC2c2ccccc2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	145977256	162985	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	391	4	1	3	3.5	O=C1Nc2ccccc2C12CCN(CCN1CC=C(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4202947	162985	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	391	4	1	3	3.5	O=C1Nc2ccccc2C12CCN(CCN1CC=C(c3ccc(F)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	118731350	117671	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	10	1	4	4.3	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409034	117671	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	490	10	1	4	4.3	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	71602692	89245	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376461	89245	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccccc1-c1ccccc1CN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2013.02.038
	23151712	120012	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310120	120012	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545471	120012	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	118736369	118423	0	None	-4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	541	8	1	10	3.1	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423333	118423	0	None	-4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	541	8	1	10	3.1	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(-c4ccccc4)cn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	16754	85134	43	None	2	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL228082	85134	43	None	2	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	44437335	151113	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL396396	151113	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	722	16	0	11	5.0	COc1ccccc1N1CCN(CCc2cccc(OC(=O)COCC(=O)Oc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	10593348	96833	0	None	4	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	CHEMBL26907	96833	0	None	4	4	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	341	1	1	2	5.1	Cc1cccc(O)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm0108505
	11375902	165669	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)CCCC2NC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	CHEMBL426723	165669	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccc2c(c1)CCCC2NC(=O)CCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm049702f
	11121721	119234	0	None	-6	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	0	4	3.9	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
	CHEMBL347837	119234	0	None	-6	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	352	8	0	4	3.9	COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1	10.1021/jm020994z
	11058564	101590	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	2	3	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCC(O)(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL302093	101590	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	404	6	2	3	4.4	O=C1Nc2cccc3c2C1(CCCCN1CCC(O)(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	134146195	154042	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3941795	154042	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3991399	154042	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL5088232	213362	0	None	-28	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2ccc3ccccc3c2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	72549988	113562	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	11	1	4	5.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326978	113562	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	11	1	4	5.4	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	72547876	113571	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2014.07.026
	CHEMBL3326987	113571	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	487	11	1	5	5.0	COc1ccc(-c2ccccc2CNC(=O)CCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2014.07.026
	155540755	172365	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	6	3.8	COc1ccc(Cl)cc1N1CCN(CCCCc2nc3ccsc3c(=O)[nH]2)CC1	10.1016/j.ejmech.2019.111690
	CHEMBL4516999	172365	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	6	3.8	COc1ccc(Cl)cc1N1CCN(CCCCc2nc3ccsc3c(=O)[nH]2)CC1	10.1016/j.ejmech.2019.111690
	46205701	124062	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
	CHEMBL3640601	124062	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
	46205701	124062	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
	CHEMBL3640601	124062	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	0	1	4.1	Cc1ccc(-c2ccccc2C2CCN(C)C2)cc1	nan
	71602583	89248	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376469	89248	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	155522563	176072	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4453687	176072	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598088	176072	0	None	-9	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	483	8	0	4	5.4	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	162674779	183187	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4798599	183187	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804025	183187	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	10	1	4	5.1	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	13069611	120086	0	None	-363	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3360995	120086	0	None	-363	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL3546110	120086	0	None	-363	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	426	7	0	9	1.0	COc1ccccc1N1CCN(CCCCn2cnc3c2c(=O)n(C)c(=O)n3C)CC1	10.1016/j.bmc.2014.11.008
	90656684	110474	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2ccc3ccccc3c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262409	110474	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	375	6	1	4	4.2	CN(CCCN1CCN(c2ccc3ccccc3c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	71602583	89248	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376469	89248	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	358	5	0	3	4.7	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2013.02.038
	137646045	157235	0	None	-436	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	404	4	0	5	4.3	CN(C)CC1=Cc2cn(S(=O)(=O)c3cccc4ccccc34)c3cccc(c23)O1	10.1021/acsmedchemlett.6b00482
	CHEMBL4083059	157235	0	None	-436	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	404	4	0	5	4.3	CN(C)CC1=Cc2cn(S(=O)(=O)c3cccc4ccccc34)c3cccc(c23)O1	10.1021/acsmedchemlett.6b00482
	242	467	117	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	34	467	117	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	60795	467	117	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	CHEMBL1112	467	117	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	DB01238	467	117	None	-15	52	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2018.01.002
	134146185	148293	0	None	18	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2cccnc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3941102	148293	0	None	18	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2cccnc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	138691362	170374	0	None	48	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	225	2	1	2	3.4	CCn1cncc1-c1c[nH]c2ccc(C)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4455588	170374	0	None	48	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	225	2	1	2	3.4	CCn1cncc1-c1c[nH]c2ccc(C)cc12	10.1016/j.ejmech.2019.03.017
	127038034	136133	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	416	9	1	4	3.8	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1039/C5MD00166H
	CHEMBL3740209	136133	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	416	9	1	4	3.8	CC(C)CS(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1	10.1039/C5MD00166H
	134146195	154042	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3941795	154042	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	CHEMBL3991399	154042	0	None	-3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	362	5	0	3	5.8	Clc1ccc2sc(CCCCN3CCC4CCCCC4C3)nc2c1	10.1016/j.bmc.2016.09.019
	24854106	160502	1	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
	CHEMBL411663	160502	1	None	-2	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
	162668734	182012	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4788259	182012	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	470	8	1	5	4.7	COc1ccc(-c2ccccc2N2CCN(C[C@@H](O)COc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
	134133968	153974	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3899099	153974	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3990801	153974	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	132547275	141699	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1cccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)c1	10.1016/j.bmc.2016.12.039
	CHEMBL3884714	141699	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	9	0	5	5.2	Clc1cccc(N2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)c1	10.1016/j.bmc.2016.12.039
	44424664	85274	0	None	-4	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL228881	85274	0	None	-4	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	73349361	92102	0	None	-5	7	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	CHEMBL2432058	92102	0	None	-5	7	Human	5.4	pKi	=	5.4	Binding	Inhibition of 5-HT7 receptor (unknown origin) by PDSP assayInhibition of 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	76332581	105919	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121426	105919	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139510	105919	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	417	4	0	3	6.1	c1ccc(N2CCN(Cc3cn(-c4ccc5ccccc5c4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	53325850	56701	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1Cl	10.1016/j.bmcl.2010.11.078
	CHEMBL1644271	56701	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1Cl	10.1016/j.bmcl.2010.11.078
	5074	3268	75	None	-74	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	97	3268	75	None	-74	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	CHEMBL267777	3268	75	None	-74	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	DB12693	3268	75	None	-74	30	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10.1021/jm030030n
	145983059	165082	0	None	-6	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243932	165082	0	None	-6	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	492	6	0	6	4.4	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	90654846	112186	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233672	112186	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304317	112186	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	466	9	0	4	4.4	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	134133968	153974	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3899099	153974	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3990801	153974	0	None	-1	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	356	5	0	3	5.3	Clc1cccc2c1CN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.09.019
	164621388	185144	0	None	-7	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
	CHEMBL4866058	185144	0	None	-7	7	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
	53323115	56709	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644279	56709	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	306	3	1	2	4.0	Fc1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	44439390	147259	0	None	33	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	4	2	3	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL393275	147259	0	None	33	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	322	4	2	3	3.6	COc1cccc(CC2NCCc3c2[nH]c2ccc(OC)cc32)c1	10.1016/j.bmcl.2007.01.093
	132547278	141704	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	10	0	6	4.3	CCOc1ccccc1N1CCN(CCCCCn2cnc(-c3ccccc3)cc2=O)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884778	141704	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	446	10	0	6	4.3	CCOc1ccccc1N1CCN(CCCCCn2cnc(-c3ccccc3)cc2=O)CC1	10.1016/j.bmc.2016.12.039
	76284455	104519	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	491	11	1	5	4.3	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113600	104519	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	491	11	1	5	4.3	COc1ccc(CNC(=O)CCOCCN2CCN(c3ccccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	135398737	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	38	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	722	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	CHEMBL42	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	DB00363	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)Displacement of [3H]-5-CT from 5-HT7b receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/acsmedchemlett.6b00482
	135398737	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	38	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	722	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	CHEMBL42	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	DB00363	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.111857
	118713685	113878	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	9	0	5	4.4	O=c1oc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331388	113878	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	393	9	0	5	4.4	O=c1oc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	6603866	96966	15	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
	CHEMBL26998	96966	15	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
	CHEMBL541268	96966	15	None	-39	9	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm030826m
	11058267	202692	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	391	6	1	5	3.0	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ncccn2)CC1)CCC3	10.1021/jm0104264
	CHEMBL72008	202692	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	391	6	1	5	3.0	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ncccn2)CC1)CCC3	10.1021/jm0104264
	71602740	89173	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2375370	89173	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
	164621388	185144	0	None	-7	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
	CHEMBL4866058	185144	0	None	-7	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	0	3	3.7	Clc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)C2	10.1016/j.ejmech.2021.113243
	44324572	205033	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	319	2	2	3	4.1	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(F)(F)F)c1	10.1016/s0960-894x(02)00925-3
	CHEMBL90150	205033	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranesInhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes	ChEMBL	319	2	2	3	4.1	Cc1c(NC2=NCCN2)cccc1-c1cccc(C(F)(F)F)c1	10.1016/s0960-894x(02)00925-3
	162670644	182387	0	None	17	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	417	9	0	5	5.2	COc1ccc(-c2ccccc2C2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4793310	182387	0	None	17	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	417	9	0	5	5.2	COc1ccc(-c2ccccc2C2CCN(CCCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	156017025	177142	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	351	2	0	1	6.1	CN(C)C1CCc2c(cccc2-c2c3ccccc3cc3ccccc23)C1	10.1016/j.bmc.2019.115262
	CHEMBL4642336	177142	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	351	2	0	1	6.1	CN(C)C1CCc2c(cccc2-c2c3ccccc3cc3ccccc23)C1	10.1016/j.bmc.2019.115262
	11221282	56704	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	333	4	1	4	3.8	O=[N+]([O-])c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644274	56704	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	333	4	1	4	3.8	O=[N+]([O-])c1ccc(-c2cn(Cc3ccccc3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	162664163	183131	2	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4782285	183131	2	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803403	183131	2	None	-56	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	409	9	1	4	4.8	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	46204736	124042	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	CHEMBL3640581	124042	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	46204736	124042	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	CHEMBL3640581	124042	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	5	1	3	3.4	CCOc1ccc(-c2ccccc2C)cc1OC1CNC1	nan
	156013736	176679	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	404	6	1	4	4.2	C#CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4636165	176679	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	404	6	1	4	4.2	C#CCOc1c(OC)cc2c3c1-c1cc(NC(=O)CCC)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	44408995	75068	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
	CHEMBL204174	75068	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	381	8	0	5	3.3	CCOC(=O)[C@H]1CCCN(CCCC(C)(C)S(=O)(=O)c2ccccc2)C1	10.1016/j.bmcl.2005.11.067
	90654858	112190	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233678	112190	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304355	112190	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	550	9	0	4	6.2	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.01.065
	155539600	172280	0	None	-239	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	7	2.7	CC(Sc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4515075	172280	0	None	-239	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	364	4	1	7	2.7	CC(Sc1ccccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	155524228	170298	0	None	-141	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(F)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL4454176	170298	0	None	-141	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CCN(CCCCN4C(=O)CC(c5c[nH]c6ccc(F)cc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2019.111736
	11761105	53344	0	None	-13	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	396	10	0	5	4.3	COc1cccc(C(=O)CCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	CHEMBL160286	53344	0	None	-13	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	396	10	0	5	4.3	COc1cccc(C(=O)CCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	71454998	80991	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	9	1	4	4.5	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159460	80991	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	9	1	4	4.5	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
	71574206	85827	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	512	7	1	5	4.7	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312641	85827	0	None	-1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	512	7	1	5	4.7	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.ejmech.2012.11.042
	90654852	112126	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233675	112126	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302762	112126	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	484	9	0	4	4.5	CC1(C)C(=O)N(Cc2ccc(F)cc2)C(=O)N1CCCCCN1CCN(c2ccc(F)cc2)CC1	10.1016/j.ejmech.2014.01.065
	155561901	175173	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	259	3	1	3	3.2	CCn1cncc1-c1c[nH]c2ccc(OC)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4583507	175173	0	None	5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	259	3	1	3	3.2	CCn1cncc1-c1c[nH]c2ccc(OC)c(F)c12	10.1016/j.ejmech.2019.03.017
	71602740	89173	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2375370	89173	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1ccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2013.02.038
	23661734	90441	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	425	6	0	4	3.8	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
	CHEMBL239259	90441	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7 expressed in HEK293 cellsDisplacement of [3H]5-CT from human 5HT7 expressed in HEK293 cells	ChEMBL	425	6	0	4	3.8	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)C1	10.1016/j.bmc.2007.07.029
	44439395	91364	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	296	2	3	2	3.4	Oc1c(F)cccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	CHEMBL241280	91364	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	296	2	3	2	3.4	Oc1c(F)cccc1CC1NCCc2c1[nH]c1ccccc21	10.1016/j.bmcl.2007.01.093
	72550641	113576	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	477	9	1	4	5.2	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326992	113576	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	477	9	1	4	5.2	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	117209857	184545	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	184545	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL5089348	213419	0	None	-23	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.1c00497
	135367405	163633	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	163633	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	118713591	113865	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331260	113865	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	401	6	0	5	4.3	O=c1sc2ccccc2n1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
	9862256	205381	0	None	-301	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	CHEMBL92139	205381	0	None	-301	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	328	5	0	4	3.0	CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1	10.1021/jm010943m
	11122723	50718	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	423	9	1	7	4.1	COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1	10.1021/jm020994z
	CHEMBL157840	50718	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	423	9	1	7	4.1	COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1	10.1021/jm020994z
	163409061	191581	2	None	-13	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	456	8	1	6	3.2	O=C(NCCCCCCn1nc2ccccn2c1=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	CHEMBL5204274	191581	2	None	-13	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	456	8	1	6	3.2	O=C(NCCCCCCn1nc2ccccn2c1=O)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2022.114319
	155536809	171622	0	None	3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4473710	171622	0	None	3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	412	5	0	4	3.2	O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	128	149	9	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
	172267	149	9	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
	CHEMBL273273	149	9	None	-295	8	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/acs.jmedchem.7b01898
	1220	186	46	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	31	186	46	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	7	186	46	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	CHEMBL56	186	46	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm030030n
	71062646	148999	0	None	-776	13	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	CHEMBL3946661	148999	0	None	-776	13	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	122181337	121352	0	None	-21	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	462	7	1	5	3.4	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590089	121352	0	None	-21	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	462	7	1	5	3.4	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
	127028471	137640	0	None	8	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3769606	137640	0	None	8	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3Cl)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	117209857	184545	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	184545	1	None	-1	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	57325521	71211	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1949977	71211	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	CHEMBL1963103	71211	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	498	6	0	5	4.5	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3ccc(Cl)cc3)CC2)CC1	10.1016/j.bmc.2011.12.039
	24854106	160502	1	None	-2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
	CHEMBL411663	160502	1	None	-2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm200547z
	135367405	163633	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	163633	0	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	42625445	186186	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	CHEMBL489028	186186	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	6	0	3	4.3	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	162662892	181322	0	None	20	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4779459	181322	0	None	20	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)cc3F)CC2)cc1	10.1016/j.ejmech.2020.112395
	135398737	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	38	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	722	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	CHEMBL42	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	DB00363	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.03.017
	72548117	113574	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(C)c2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326990	113574	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2cccc(C)c2)CC1	10.1016/j.bmc.2014.07.026
	135398737	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	38	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	722	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	CHEMBL42	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	DB00363	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	CHEMBL5093250	213635	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)c(F)c1	10.1021/acs.jmedchem.1c00497
	46205368	124049	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
	CHEMBL3640588	124049	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
	46205368	124049	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
	CHEMBL3640588	124049	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	291	3	1	2	3.8	Cc1cc(-c2ccc(Cl)cc2OC2CNC2)ccc1F	nan
	162666903	183142	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4787550	183142	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803553	183142	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	369	7	2	5	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccccc2O)CC1	10.1016/j.ejmech.2020.112437
	2133793	21602	12	None	1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	476	5	2	5	6.2	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL1319488	21602	12	None	1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	476	5	2	5	6.2	O=S(=O)(Nc1cc(Sc2cccc3cccnc23)c(O)c2ccccc12)c1ccc(F)cc1	10.1016/j.bmcl.2015.03.049
	3649661	137678	6	None	-64	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770106	137678	6	None	-64	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	76518514	113025	0	None	-50	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321788	113025	0	None	-50	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	118736395	118431	0	None	-234	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	493	7	1	11	0.7	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423377	118431	0	None	-234	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	493	7	1	11	0.7	Cn1c(=O)c2c(nc3n(CCCCCN4CCN(c5ccccc5O)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	168287240	191131	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	7	4.4	Nc1nc(NCCOc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5197266	191131	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	7	4.4	Nc1nc(NCCOc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	155534301	171359	0	None	-11	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	415	8	0	5	4.0	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4470304	171359	0	None	-11	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	415	8	0	5	4.0	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2019.06.029
	90654678	109597	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	2	5	2.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235750	109597	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	2	5	2.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2014.03.005
	44424652	85483	0	None	-2	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	426	7	0	9	1.0	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229940	85483	0	None	-2	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	426	7	0	9	1.0	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	90654699	109583	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235736	109583	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	406	8	1	4	2.5	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
	52952309	62246	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	427	7	1	6	4.8	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
	CHEMBL1782807	62246	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	427	7	1	6	4.8	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
	13069602	120087	0	None	-478	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360996	120087	0	None	-478	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546112	120087	0	None	-478	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	430	6	0	8	1.7	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	76310811	105783	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121417	105783	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139021	105783	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	395	5	0	3	5.5	CCc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	6603866	96966	15	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	CHEMBL26998	96966	15	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	CHEMBL541268	96966	15	None	-95	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1016/j.bmc.2019.115262
	135398737	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	38	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	722	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	CHEMBL42	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	DB00363	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
	23369455	180883	2	None	1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	350	6	1	4	2.9	O=c1[nH]c2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL476462	180883	2	None	1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	350	6	1	4	2.9	O=c1[nH]c2ccccc2n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	135398737	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	38	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	722	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	CHEMBL42	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	DB00363	942	89	None	-13	92	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.ejmech.2019.06.001
	11248332	83879	0	None	-2	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL221513	83879	0	None	-2	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	127036953	136977	0	None	-4	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3754166	136977	0	None	-4	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
	117209971	185893	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	185893	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL5076846	212683	0	None	-75	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2cc3ccc(F)cc3s2)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	9926401	140331	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819556	140331	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819732	140331	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	53377239	66043	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851772	66043	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
	CHEMBL3217162	66043	0	None	-15	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	443	7	0	7	3.6	COc1cccc(N2CCN(CCCCn3cnc4c(cnc5ccccc54)c3=O)CC2)c1	10.1016/j.ejmech.2011.04.060
	155514217	169254	0	None	-17	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	461	8	0	5	3.9	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4439795	169254	0	None	-17	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	461	8	0	5	3.9	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	155551685	174550	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	495	8	0	5	4.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4569757	174550	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	495	8	0	5	4.5	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2021.128028
	164618482	185323	0	None	-13	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2020.112529
	CHEMBL4868911	185323	0	None	-13	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3ccc(Cl)c(Cl)c3)n2)CC1	10.1016/j.ejmech.2020.112529
	155552799	175721	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4545270	175721	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595236	175721	0	None	-91	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.2	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	9878197	194494	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	250	4	4	3	1.0	CCOc1ccccc1CNC(=N)NC(=O)NC	10.1016/j.bmcl.2009.06.038
	CHEMBL561346	194494	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	250	4	4	3	1.0	CCOc1ccccc1CNC(=N)NC(=O)NC	10.1016/j.bmcl.2009.06.038
	127037921	136494	0	None	4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	9	0	6	3.7	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.bmc.2015.11.041
	CHEMBL3746493	136494	0	None	4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	9	0	6	3.7	Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.bmc.2015.11.041
	155512944	169141	0	None	11	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	249	1	1	2	3.4	Cn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4438349	169141	0	None	11	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	249	1	1	2	3.4	Cn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
	127038035	136181	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1039/C5MD00166H
	CHEMBL3740691	136181	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccccc1	10.1039/C5MD00166H
	117209971	185893	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	185893	1	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	9926401	140331	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819556	140331	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819732	140331	0	None	2	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	24768517	92382	0	None	2	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243742	92382	0	None	2	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	57397588	71120	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926747	71120	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962460	71120	0	None	-24	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	90654691	109575	0	None	-21	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	432	10	1	5	3.0	CSc1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235728	109575	0	None	-21	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	432	10	1	5	3.0	CSc1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	162673808	183182	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4795248	183182	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803963	183182	0	None	-23	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	11421045	136405	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	CHEMBL374298	136405	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	447	9	1	4	4.8	CC(=O)c1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	134133633	154043	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3899822	154043	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3991400	154043	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	44582678	180982	0	None	-275	11	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476839	180982	0	None	-275	11	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	44393088	64667	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182322	64667	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	386	8	3	7	3.4	CC(Nc1nc(N)nc(NCCOc2ccc(F)cc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	44393170	64889	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182680	64889	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	C[C@H](Nc1cc(NCCc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	44393171	65043	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182943	65043	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	8	2	5	4.3	C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ncn1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	10785714	20013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030030n
	CHEMBL13052	20013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030030n
	127042184	136445	0	None	6	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	468	8	0	4	4.7	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
	CHEMBL3745815	136445	0	None	6	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	468	8	0	4	4.7	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
	2865	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	59	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	60854	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	CHEMBL708	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	DB00246	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.ejmech.2018.01.002
	71458625	80949	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	3.6	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159322	80949	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	3.6	CSc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	71458626	80950	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159323	80950	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	440	8	1	4	3.9	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	118731356	117676	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409039	117676	0	None	1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	502	8	0	4	4.6	O=C([C@@H]1CCCN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	138691364	171331	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4469847	171331	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1016/j.ejmech.2019.03.017
	138691364	171331	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
	CHEMBL4469847	171331	2	None	24	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	254	3	2	3	2.2	CCn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
	145982165	166040	0	None	51	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc4ccccc34)C2=O)CC1	10.1039/C8MD00168E
	CHEMBL4280511	166040	0	None	51	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	488	7	2	6	2.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc4ccccc34)C2=O)CC1	10.1039/C8MD00168E
	137651887	156745	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	7	2	3	4.6	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4077040	156745	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	443	7	2	3	4.6	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	9845006	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL12702	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/j.bmc.2019.06.028
	11646336	65650	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm200547z
	CHEMBL1836785	65650	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(F)cc2)CC1	10.1021/jm200547z
	44372581	119301	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	420	6	1	2	5.8	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL348410	119301	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	420	6	1	2	5.8	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	9845006	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12702	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1016/s0960-894x(00)00166-9
	10785714	20013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	CHEMBL13052	20013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1016/s0960-894x(00)00166-9
	9845006	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
	CHEMBL12702	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm030841r
	10785714	20013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	CHEMBL13052	20013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm030841r
	162659494	180762	0	None	-15	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4763085	180762	0	None	-15	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
	162674158	182411	0	None	-12	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
	CHEMBL4793608	182411	0	None	-12	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	441	7	1	6	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1csc2ccccc12	10.1016/j.ejmech.2020.112149
	107	141	116	None	-3	31	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
	1833	141	116	None	-3	31	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
	CHEMBL8165	141	116	None	-3	31	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	10.1016/j.ejmech.2019.111705
	2865	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	59	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	60854	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	CHEMBL708	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	DB00246	4064	67	None	-12	54	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	11536843	114612	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	114612	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	54758293	65651	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.3	CCC1(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL1836786	65651	0	None	7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	445	7	1	3	5.3	CCC1(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	56944186	111585	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	8	1	7	4.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3289984	111585	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	504	8	1	7	4.6	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	56944190	111595	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	499	8	1	5	5.2	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289994	111595	0	None	-1	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	499	8	1	5	5.2	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	25107578	192444	0	None	4	3	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	CHEMBL522343	192444	0	None	4	3	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	10.1021/jm800615e
	24854370	156516	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL407412	156516	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	9845006	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL12702	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	9845006	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
	CHEMBL12702	18040	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	419	7	1	4	4.2	COc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm980519u
	118713680	113873	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	411	8	0	6	4.1	COc1ccccc1N1CCN(CCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331383	113873	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	411	8	0	6	4.1	COc1ccccc1N1CCN(CCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	92042876	150792	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	150792	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	10402615	200821	0	None	-20	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
	CHEMBL611472	200821	0	None	-20	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	301	2	0	1	4.9	CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1	10.1016/j.bmc.2019.115262
	92042876	150792	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3961059	150792	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	10785714	20013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	CHEMBL13052	20013	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.	ChEMBL	375	5	1	3	3.8	O=C1Nc2cccc3c2C1(CCCN1CCN(c2ccccc2)CC1)CCC3	10.1021/jm980519u
	92042876	150792	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	150792	0	None	2	10	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	71457985	78113	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@@H](N(C)C)C2	10.1016/j.bmcl.2004.11.013
	CHEMBL2112053	78113	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@@H](N(C)C)C2	10.1016/j.bmcl.2004.11.013
	11153905	65260	0	None	-2	2	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1021/jm0498102
	CHEMBL183329	65260	0	None	-2	2	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	313	4	0	4	3.2	COc1cccc(OC)c1-c1cccc2c1OC[C@H](N(C)C)C2	10.1021/jm0498102
	156013466	176925	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	CHEMBL4639638	176925	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	156013520	176927	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	CHEMBL4639661	176927	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	66801140	111158	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3286432	111158	0	None	2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	482	8	1	6	4.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	24854039	95310	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL258537	95310	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	11603891	96454	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL265927	96454	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm070279v
	11617668	64350	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
	CHEMBL181874	64350	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Human 5-HT7R expressed in sf9 cellsBinding affinity against Human 5-HT7R expressed in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2005.05.059
	11603891	96454	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL265927	96454	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	407	8	1	4	4.3	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	11617668	64350	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2007.03.054
	CHEMBL181874	64350	0	None	3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	372	5	0	5	3.7	COc1ccccc1N1CCN(Cc2ccn(-c3ccccc3C#N)c2)CC1	10.1016/j.bmcl.2007.03.054
	46205370	124051	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
	CHEMBL3640590	124051	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
	46205370	124051	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
	CHEMBL3640590	124051	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	1	2	3.7	COc1ccc(-c2ccccc2C)cc1C1CCNC1	nan
	162650362	179423	0	None	-27	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4747225	179423	0	None	-27	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc2ccccc2c1	10.1016/j.ejmech.2020.112149
	135398737	942	89	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	38	942	89	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	722	942	89	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	CHEMBL42	942	89	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	DB00363	942	89	None	-13	92	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	10706553	97234	0	None	5	5	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL27132	97234	0	None	5	5	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	261	0	0	1	3.9	C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	101747513	172740	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	277	4	0	5	3.2	CN(C)CCSc1nc2ccsc2n2cccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4526441	172740	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant	ChEMBL	277	4	0	5	3.2	CN(C)CCSc1nc2ccsc2n2cccc12	10.1016/j.ejmech.2019.111690
	154926523	189687	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	425	9	1	4	4.2	CC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
	CHEMBL5175774	189687	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity to rat 5-HT7 receptor assessed as inhibition constantBinding affinity to rat 5-HT7 receptor assessed as inhibition constant	ChEMBL	425	9	1	4	4.2	CC1(CCCCN2CCN(c3cccc(OCCF)c3)CC2)C(=O)Nc2ccccc21	10.1021/acs.jmedchem.2c00633
	11976	905	54	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
	667467	905	54	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
	CHEMBL908	905	54	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
	DB01239	905	54	None	-5	24	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1021/jm030030n
	23661594	90180	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL238808	90180	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	664	16	0	8	6.3	COc1ccccc1N1CCN(CCc2cccc(OCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	25107718	186945	0	None	18	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1021/jm800615e
	CHEMBL494458	186945	0	None	18	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	10.1021/jm800615e
	9887186	202584	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	399	5	2	2	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3	10.1021/jm0104264
	CHEMBL71383	202584	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	399	5	2	2	4.9	O=C1Nc2cccc3c2C1(CCCCN1CCc2c([nH]c4ccccc24)C1)CCC3	10.1021/jm0104264
	10948963	48735	0	None	-1	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
	CHEMBL156089	48735	0	None	-1	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	1	5	4.0	COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1	10.1021/jm020994z
	135398737	942	89	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	38	942	89	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	722	942	89	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	CHEMBL42	942	89	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	DB00363	942	89	None	-13	92	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2013.12.024
	156011291	176792	0	None	-9	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	CHEMBL4637900	176792	0	None	-9	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	341	6	0	1	6.0	CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1	10.1016/j.bmc.2019.115262
	118713679	113872	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	6	3.6	COc1ccccc1N1CCN(CCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331382	113872	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	395	8	0	6	3.6	COc1ccccc1N1CCN(CCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	56944189	111588	0	None	2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	454	8	1	8	2.4	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3289987	111588	0	None	2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	454	8	1	8	2.4	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	24854272	95739	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
	CHEMBL260761	95739	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(F)cc21	10.1021/jm070279v
	46204081	124017	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
	CHEMBL3640558	124017	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
	46204081	124017	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
	CHEMBL3640558	124017	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	285	5	1	4	2.7	COc1ccc(-c2ccccc2OC)cc1OC1CNC1	nan
	90654704	109588	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	413	8	1	6	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235741	109588	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	413	8	1	6	2.0	NC(=O)[C@@H]1CCCN1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2014.03.005
	127026141	137126	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	8	1	6	3.4	Cn1cc(S(=O)(=O)NC2CC3CCC(C2)N3CCOc2cccc(-c3ccccc3)c2)cn1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758488	137126	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	466	8	1	6	3.4	Cn1cc(S(=O)(=O)NC2CC3CCC(C2)N3CCOc2cccc(-c3ccccc3)c2)cn1	10.1016/j.ejmech.2015.11.040
	155562997	174655	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.ejmech.2019.111736
	CHEMBL4571862	174655	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	486	7	2	3	5.3	O=C1CC(c2c[nH]c3ccc(F)cc23)C(=O)N1CCCCN1CCC(c2c[nH]c3ccccc23)CC1	10.1016/j.ejmech.2019.111736
	145946840	167014	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4176588	167014	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4300745	167014	0	None	3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	7	2	6	2.0	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(C)cc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	57394663	71196	0	None	-2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949973	71196	0	None	-2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963031	71196	0	None	-2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	457	8	1	4	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.12.039
	118706294	120011	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310118	120011	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3545470	120011	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	122178708	120847	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581253	120847	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	53248365	61742	0	None	-52	7	Human	7.3	pKi	=	7.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	554	6	1	5	2.9	O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I	10.1021/jm1009956
	CHEMBL1774995	61742	0	None	-52	7	Human	7.3	pKi	=	7.3	Binding	Inhibition of 5HT7 receptorInhibition of 5HT7 receptor	ChEMBL	554	6	1	5	2.9	O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I	10.1021/jm1009956
	277	1269	55	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	2913	1269	55	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	765	1269	55	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL516	1269	55	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	DB00434	1269	55	None	-43	46	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1016/s0960-894x(00)00166-9
	8431	1451	6	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	9843179	1451	6	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	CHEMBL69257	1451	6	None	-22	5	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10.1021/jm030841r
	277	1269	55	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	2913	1269	55	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	765	1269	55	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	CHEMBL516	1269	55	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	DB00434	1269	55	None	-70	46	Human	7.3	pKi	=	7.3	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1021/jm030841r
	155549018	173660	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4548926	173660	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2016.06.080
	191	399	92	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	201	399	92	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	2170	399	92	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	CHEMBL1113	399	92	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	DB00543	399	92	None	-41	29	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1021/jm030030n
	44439399	146847	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	5	0	5	4.8	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL392970	146847	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	5	0	5	4.8	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(OC(C)=O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
	59752538	180560	0	None	-251	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4760784	180560	0	None	-251	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	156308	168706	1	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	354	2	0	4	3.2	COc1ccc2c(c1OC)C[N+]1(C)CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmcl.2007.01.093
	CHEMBL441356	168706	1	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	354	2	0	4	3.2	COc1ccc2c(c1OC)C[N+]1(C)CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmcl.2007.01.093
	10287730	3467	36	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	77	3467	36	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	CHEMBL425190	3467	36	None	-630	12	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 7 receptor Binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	11304596	56087	0	None	-3162	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631542	56087	0	None	-3162	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	134133633	154043	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3899822	154043	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	CHEMBL3991400	154043	0	None	-3	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	407	5	0	1	6.9	Clc1ccc(C(=CCCN2CCc3ccccc3C2)c2ccc(Cl)cc2)cc1	10.1016/j.bmc.2016.09.019
	1220	186	46	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
	31	186	46	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
	7	186	46	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
	CHEMBL56	186	46	None	-199	45	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2019.111705
	135367400	163408	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207901	163408	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	127052778	140301	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819403	140301	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	5242341	196469	2	None	-30	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	0	5	3.7	O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL574827	196469	2	None	-30	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	396	6	0	5	3.7	O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2015.02.042
	135367400	163408	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207901	163408	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1cccc(-c2noc3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	46204733	124039	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
	CHEMBL3640579	124039	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
	46204733	124039	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
	CHEMBL3640579	124039	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	264	3	1	3	2.9	Cc1ccccc1-c1ccc(C#N)c(OC2CNC2)c1	nan
	155552213	176074	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4546775	176074	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598090	176074	0	None	-54	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	481	8	0	3	6.5	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2019.06.028
	164615243	184617	0	None	-21	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4857676	184617	0	None	-21	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	90654671	109590	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	8	1	5	3.1	CSc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235743	109590	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	466	8	1	5	3.1	CSc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	145984511	165061	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4243497	165061	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cncc2ccccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	156016856	177092	0	None	-39	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	295	2	0	1	4.4	Fc1ccccc1-c1cccc2c1CCC(N1CCCC1)C2	10.1016/j.bmc.2019.115262
	CHEMBL4641769	177092	0	None	-39	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	295	2	0	1	4.4	Fc1ccccc1-c1cccc2c1CCC(N1CCCC1)C2	10.1016/j.bmc.2019.115262
	155513438	169151	0	None	-10	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	346	6	3	3	4.8	Cc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4438434	169151	0	None	-10	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	346	6	3	3	4.8	Cc1ccc2[nH]cc(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	56945042	157485	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4085802	157485	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	44424659	85329	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229231	85329	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL2448068	85329	0	None	-4	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	474	8	0	9	2.1	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2007.05.017
	127052467	140307	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819494	140307	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
	11747350	106835	0	None	-25	11	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	260	5	1	3	2.4	CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C	10.1021/jm010943m
	CHEMBL317535	106835	0	None	-25	11	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HTBinding affinity for 5-hydroxytryptamine 7 receptor human cloned receptors in CHO cells using [3H]5-HT	ChEMBL	260	5	1	3	2.4	CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C	10.1021/jm010943m
	118736366	118420	0	None	-257	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	6	1	10	1.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423330	118420	0	None	-257	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	465	6	1	10	1.3	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCN1CCN(c2ccccc2O)CC1	10.1016/j.ejmech.2015.04.046
	25263297	183745	0	None	-645	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
	CHEMBL484345	183745	0	None	-645	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
	135464118	92614	0	None	-14	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442272	92614	0	None	-14	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	122483262	137548	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763883	137548	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765837	137548	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	60167452	74989	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL2037526	74989	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	6604117	187254	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL2062340	187254	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL49623	187254	6	None	-5	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	122483262	137548	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763883	137548	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765837	137548	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	370	7	0	3	5.7	CN(CCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	155562918	174601	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4570584	174601	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	314	4	1	7	1.1	Cc1ccccc1OCc1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	162674513	183186	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4798559	183186	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804009	183186	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	437	9	1	4	5.3	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	122181340	121355	0	None	-14	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590092	121355	0	None	-14	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	460	7	1	4	4.2	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	162661627	183117	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4778919	183117	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803268	183117	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	425	11	1	5	3.7	COc1ccccc1CNC(=O)CCCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	118464425	137768	0	None	-13	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770981	137768	0	None	-13	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT7A receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	44582677	180981	0	None	-194	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476838	180981	0	None	-194	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	60167452	74989	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037526	74989	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	60167452	74989	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL2037526	74989	0	None	-28	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	448	7	1	6	4.1	O=C(CCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	46205372	124053	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
	CHEMBL3640592	124053	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
	10904975	164304	0	None	17	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	379	7	1	6	3.7	O=C(CCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL422008	164304	0	None	17	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	379	7	1	6	3.7	O=C(CCCCN1CCN(c2noc3ccccc23)CC1)c1ccccc1O	10.1021/jm020994z
	11327137	66392	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	403	8	1	5	2.5	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
	CHEMBL185762	66392	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	403	8	1	5	2.5	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
	46205372	124053	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
	CHEMBL3640592	124053	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	289	3	1	2	3.7	COc1ccc(-c2cccc(F)c2F)cc1C1CCNC1	nan
	CHEMBL5094680	213724	0	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	137631892	155832	0	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4066426	155832	0	None	2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	137660741	158810	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4100470	158810	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cncc2ccccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	145985718	164962	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4241081	164962	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1cccc2ncccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	118626169	165012	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4242268	165012	0	None	-7	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	134147124	149436	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2ncccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3950020	149436	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	512	10	1	5	4.6	O=C(CCOCCN1CCN(c2ncccc2-c2ccccc2)CC1)NCc1ccc(C(F)(F)F)cc1	10.1016/j.ejmech.2016.05.005
	145975106	163098	0	None	30	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	1	4	5.2	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
	CHEMBL4204459	163098	0	None	30	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	1	4	5.2	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2017.03.057
	145972875	164165	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4217506	164165	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	9	1	4	4.2	CC(C)c1ccccc1OCCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2017.03.057
	109026949	174024	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	392	6	0	4	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4557369	174024	1	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	392	6	0	4	2.5	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2016.06.080
	54758296	65658	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	426	7	1	2	6.0	CCC1(CCCCN2CC=C(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	CHEMBL1836793	65658	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	426	7	1	2	6.0	CCC1(CCCCN2CC=C(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(F)cc21	10.1021/jm200547z
	127052467	140307	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819494	140307	0	None	-1	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	1	1	4.5	c1ccc2c(c1)CCN(CCCCc1c[nH]c3ccccc13)C2	10.1016/j.bmc.2016.05.053
	122178702	120841	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581247	120841	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL5094680	213724	0	None	-3	8	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	135367820	164258	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164258	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	11257340	121510	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	374	7	1	4	2.7	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccc(C)cc1)C2	10.1021/jm049743b
	CHEMBL359538	121510	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	374	7	1	4	2.7	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccc(C)cc1)C2	10.1021/jm049743b
	66801624	155949	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	6	2	3	5.4	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	CHEMBL4067700	155949	0	None	-2	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	479	6	2	3	5.4	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	11568826	132264	0	None	-446	8	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	CHEMBL370110	132264	0	None	-446	8	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against 5HT7 receptorInhibitory activity against 5HT7 receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	156010209	176570	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4634062	176570	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	164620748	185653	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	CHEMBL4873623	185653	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	164620748	185653	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4873623	185653	0	None	-147	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	16026344	22035	4	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	373	2	0	3	5.0	O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21	10.1016/j.bmcl.2015.03.049
	CHEMBL1323386	22035	4	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	373	2	0	3	5.0	O=S1(=O)c2ccccc2N(Cc2ccc(Cl)cc2F)c2ccccc21	10.1016/j.bmcl.2015.03.049
	155555506	173800	0	None	-8	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	330	6	1	2	5.1	CN(CCc1c[nH]c2ccccc12)Cc1ccc(-c2ccccc2)o1	10.1016/j.ejmech.2019.111857
	CHEMBL4552041	173800	0	None	-8	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	330	6	1	2	5.1	CN(CCc1c[nH]c2ccccc12)Cc1ccc(-c2ccccc2)o1	10.1016/j.ejmech.2019.111857
	46205041	124043	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
	CHEMBL3640582	124043	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
	46205041	124043	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
	CHEMBL3640582	124043	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	337	5	1	3	4.0	Cc1ccccc1-c1ccc(OCC(F)(F)F)c(OC2CNC2)c1	nan
	164624803	185620	0	None	-28	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4873127	185620	0	None	-28	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cccc(Cl)c1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	145978472	163040	0	None	14	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	438	4	1	4	2.7	O=C(c1ccc(Cl)cc1)N1CCN(CCN2CCC3(C2)C(=O)Nc2ccccc23)CC1	10.1016/j.bmcl.2018.06.019
	CHEMBL4203581	163040	0	None	14	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	438	4	1	4	2.7	O=C(c1ccc(Cl)cc1)N1CCN(CCN2CCC3(C2)C(=O)Nc2ccccc23)CC1	10.1016/j.bmcl.2018.06.019
	127027388	137113	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	8	1	5	3.6	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccnc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758378	137113	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	437	8	1	5	3.6	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccnc1	10.1016/j.ejmech.2015.11.040
	127042841	136468	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	488	9	0	4	5.1	CC(C)(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3746083	136468	0	None	3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	488	9	0	4	5.1	CC(C)(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2015.11.041
	76284193	146052	0	None	19	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	444	10	1	5	3.6	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3923145	146052	0	None	19	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	444	10	1	5	3.6	O=C(CCOCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	10.1016/j.ejmech.2016.05.005
	156012741	176703	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.4	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4636435	176703	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	477	8	0	4	4.4	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2020.115459
	155538367	171805	0	None	30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4476372	171805	0	None	30	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	263	2	1	2	3.8	CCn1cncc1-c1c[nH]c2ccc(Cl)c(F)c12	10.1016/j.ejmech.2019.03.017
	155541872	176101	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4519312	176101	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4598357	176101	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	447	8	0	3	5.8	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2019.06.028
	44408820	140361	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.3	O=S(=O)(c1ccccc1)C1(CCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL382163	140361	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.3	O=S(=O)(c1ccccc1)C1(CCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	24854370	156516	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL407412	156516	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	411	7	1	3	4.9	CCC1(CCCCN2CCN(c3ccccc3Cl)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	135367820	164258	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164258	0	None	8	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	134130462	141769	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	7	0	5	3.7	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3885389	141769	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	390	7	0	5	3.7	Cc1nc2ccccc2c(=O)n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	44439400	90769	0	None	2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	7	0	4	5.2	CCCOC1CCCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	CHEMBL240023	90769	0	None	2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	408	7	0	4	5.2	CCCOC1CCCc2ccc(/N=C/N3CCc4cc(OC)c(OC)cc4C3)cc21	10.1016/j.bmcl.2007.01.093
	138691317	170961	0	None	5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	211	2	1	2	3.1	CCn1cncc1-c1c[nH]c2ccccc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4464377	170961	0	None	5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	211	2	1	2	3.1	CCn1cncc1-c1c[nH]c2ccccc12	10.1016/j.ejmech.2019.03.017
	155548677	173146	0	None	-257	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	7	3	4	4.8	COc1ccc2[nH]c(C)c(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4536315	173146	0	None	-257	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	7	3	4	4.8	COc1ccc2[nH]c(C)c(CCNCc3ccc(-c4ccc(O)cc4)o3)c2c1	10.1016/j.ejmech.2019.111857
	46204419	124027	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
	CHEMBL3640567	124027	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
	46204419	124027	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
	CHEMBL3640567	124027	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	331	5	0	3	4.5	COc1ccc(-c2ccccc2Cl)cc1OC1CN(C(C)C)C1	nan
	53323535	56715	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3cccc(Cl)c3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644487	56715	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	356	3	1	2	5.2	Clc1ccc(-c2cn(Cc3cccc(Cl)c3)c3c2CNCC3)cc1	10.1016/j.bmcl.2010.11.078
	145975778	163017	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
	CHEMBL4203312	163017	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1ccccc1OCCN1CCC(NS(=O)(=O)c2ccccc2)CC1	10.1021/acs.jmedchem.8b00828
	136118659	75887	0	None	-3	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058427	75887	0	None	-3	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	71602523	89247	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2376463	89247	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	71602523	89247	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	CHEMBL2376463	89247	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	328	4	0	2	4.7	c1ccc(-c2ccccc2CN2CCN(c3ccccc3)CC2)cc1	10.1016/j.bmc.2013.02.038
	52952419	62237	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	358	5	0	5	3.3	O=C(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
	CHEMBL1782794	62237	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	358	5	0	5	3.3	O=C(CCN1CCC(N2CCOCC2)CC1)c1csc2ccccc12	10.1021/jm2000773
	10662302	98876	0	None	-2	5	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	CHEMBL282375	98876	0	None	-2	5	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor	ChEMBL	304	1	1	2	3.0	CC(=O)N[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1	10.1021/jm9911433
	24768519	92417	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243953	92417	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	44393053	64919	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	349	8	2	6	3.8	Cc1nc(NCCOc2ccccc2)nc(N[C@@H](C)c2ccccc2)n1	10.1016/j.bmcl.2004.06.008
	CHEMBL182805	64919	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	349	8	2	6	3.8	Cc1nc(NCCOc2ccccc2)nc(N[C@@H](C)c2ccccc2)n1	10.1016/j.bmcl.2004.06.008
	11372669	67066	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	388	8	0	4	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccccc1	10.1021/jm049743b
	CHEMBL188876	67066	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	388	8	0	4	3.2	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1ccccc1	10.1021/jm049743b
	76336184	105779	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121434	105779	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139017	105779	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	367	4	0	3	5.0	c1ccc(N2CCN(Cc3cn(-c4ccccc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	127026443	137300	0	None	85	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	4	3.9	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759925	137300	0	None	85	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	7	1	4	3.9	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2015.11.040
	134139826	145987	0	None	12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3922670	145987	0	None	12	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	487	10	1	6	3.6	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccc(F)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	156012823	176826	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	548	11	0	6	6.2	Cc1ccc(S(=O)(=O)N(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2ccccc2)cc1	10.1016/j.bmc.2020.115459
	CHEMBL4638388	176826	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	548	11	0	6	6.2	Cc1ccc(S(=O)(=O)N(CCCCCCN2CCN(c3nsc4ccccc34)CC2)c2ccccc2)cc1	10.1016/j.bmc.2020.115459
	21048822	139676	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	377	6	0	3	4.3	CC(C)(CCCN1CCCC(C(F)(F)F)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL380511	139676	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	377	6	0	3	4.3	CC(C)(CCCN1CCCC(C(F)(F)F)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	23661667	85323	0	None	-4	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL1203946	85323	0	None	-4	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229181	85323	0	None	-4	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2007.05.017
	66801115	111559	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	506	7	1	7	4.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3289959	111559	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	506	7	1	7	4.7	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	122178711	120850	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL3581256	120850	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	25108475	186892	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL494119	186892	0	None	-2	3	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	10.1021/jm800615e
	23661667	85323	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL1203946	85323	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
	CHEMBL229181	85323	0	None	-4	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	470	9	0	10	1.4	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2OC)CC1	10.1016/j.bmc.2014.11.008
	10333670	94335	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3c(=O)[nH]c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL253319	94335	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3c(=O)[nH]c4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	155565209	175008	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4579764	175008	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	426	6	0	4	3.2	O=C(CCN1CCN(Cc2ccccc2)CC1)N1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmcl.2016.06.080
	155535154	171466	0	None	-10	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	556	9	1	7	5.2	COc1ccc(-c2c3n(c(=O)n(CCCCN4CCCC(c5c[nH]c6ccc(OC)cc56)C4)c2=O)CCCC3)cc1	10.1016/j.ejmech.2019.07.027
	CHEMBL4471755	171466	0	None	-10	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	ChEMBL	556	9	1	7	5.2	COc1ccc(-c2c3n(c(=O)n(CCCCN4CCCC(c5c[nH]c6ccc(OC)cc56)C4)c2=O)CCCC3)cc1	10.1016/j.ejmech.2019.07.027
	145966154	163624	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	402	8	1	4	3.6	CC(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4210708	163624	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	402	8	1	4	3.6	CC(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	122483244	137554	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764136	137554	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765843	137554	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	44448054	94334	0	None	1	6	Human	7.3	pKi	=	7.3	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1021/jm060959i
	CHEMBL253318	94334	0	None	1	6	Human	7.3	pKi	=	7.3	Binding	Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor	ChEMBL	276	0	1	2	2.8	CN1CCc2ccc3[nH]c(=O)c4cccc5c4c3c2[C@H]1C5	10.1021/jm060959i
	132503215	157196	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4082456	157196	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	5.2	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.bmc.2017.04.046
	57392107	68067	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917345	68067	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
	145966418	163678	0	None	6	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3cccc(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4211253	163678	0	None	6	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	410	4	1	4	3.1	O=C1Nc2ccccc2C12CCN(CCN1CCN(c3cccc(Cl)c3)CC1)C2	10.1016/j.bmcl.2018.06.019
	46205703	124064	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
	CHEMBL3640603	124064	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
	46205703	124064	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
	CHEMBL3640603	124064	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	251	2	1	1	4.0	Cc1ccc(-c2ccccc2C2CCNC2)cc1C	nan
	44408987	76191	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.9	CC1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206269	76191	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.9	CC1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
	122483244	137554	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764136	137554	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765843	137554	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.7	CC1CCCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	5280953	96900	102	None	-6	9	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
	CHEMBL269538	96900	102	None	-6	9	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	3.0	COc1ccc2c(c1)[nH]c1c(C)nccc12	10.1016/j.bmcl.2003.09.027
	90654675	109594	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	1	5	2.4	COc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235747	109594	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	450	8	1	5	2.4	COc1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	46233381	200230	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	257	5	0	2	4.0	CN(C)CCSc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
	CHEMBL607584	200230	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	257	5	0	2	4.0	CN(C)CCSc1ccccc1-c1ccccc1	10.1016/j.bmc.2010.01.035
	137645501	157091	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	CHEMBL4081383	157091	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cell membranes after 1 hr by microbeta liquid scintillation counting analysis	ChEMBL	532	6	0	5	4.9	O=S(=O)(c1cccc2ncccc12)N1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1	10.1016/j.bmc.2017.04.046
	127028798	137643	0	None	23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769612	137643	0	None	23	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	454	6	2	5	2.4	Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	127039593	136453	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	460	10	0	6	3.5	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3745882	136453	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	460	10	0	6	3.5	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cnn(C)c2)CC1	10.1016/j.bmc.2015.11.041
	127042539	136547	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747148	136547	0	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	474	10	0	4	4.9	CC(C)c1ccccc1OCCN1CCC(N(CC2CC2)S(=O)(=O)c2cccc(F)c2)CC1	10.1016/j.bmc.2015.11.041
	71574306	85825	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312639	85825	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hr	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	57325520	71179	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949963	71179	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1962945	71179	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	135	2486	38	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	1796	2486	38	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	4184	2486	38	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	CHEMBL6437	2486	38	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	DB06148	2486	38	None	-83	58	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
	155532137	171118	0	None	16	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.3	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4466596	171118	0	None	16	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	432	7	1	5	4.3	O=c1[nH]c(CCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	168283140	190495	0	None	-34	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5OC)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5187742	190495	0	None	-34	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	463	7	0	8	3.3	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5OC)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	10365873	66900	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	438	8	0	4	4.3	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm049743b
	CHEMBL188036	66900	0	None	-	1	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	438	8	0	4	4.3	CCN(CCCN1CCc2cc(OC)ccc2C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm049743b
	127052778	140301	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819403	140301	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	505	9	0	5	6.3	O=C(CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	18377342	106616	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2[nH]cnc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL316039	106616	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2[nH]cnc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	145947762	167126	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4170484	167126	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4302327	167126	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	500	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(c3ccccc3)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	42618256	181003	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	CHEMBL477065	181003	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1ccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2009.02.008
	90654692	109576	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	6	1	5	2.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235729	109576	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	438	6	1	5	2.8	CSc1ccccc1N1CCN(Cc2ccc(C(=O)N3CCC[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	155547197	173013	0	None	-758	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	CHEMBL4533305	173013	0	None	-758	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	341	6	0	4	3.4	O=C(CCCN1CCCN(c2ccccn2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2020.115943
	145983468	164873	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238897	164873	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	493	6	0	7	3.8	O=S(=O)(c1cccc2ncccc12)N1CC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	90656677	112093	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262402	112093	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3302044	112093	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	388	7	1	5	2.3	CN(CCN1CCN(c2ccccc2)CC1)c1cccc(NS(C)(=O)=O)c1	10.1016/j.ejmech.2014.04.034
	44424666	143826	0	None	5	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	425	8	0	8	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL390580	143826	0	None	5	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	425	8	0	8	2.1	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	118706299	120013	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310121	120013	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545472	120013	0	None	-64	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	66801259	111590	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	8	3.3	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	CHEMBL3289989	111590	0	None	2	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	471	8	1	8	3.3	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccc2scnc12	10.1021/jm401895u
	44401194	70936	0	None	-7	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL195706	70936	0	None	-7	7	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	118713594	113868	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	365	7	0	5	3.6	O=c1oc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331263	113868	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	365	7	0	5	3.6	O=c1oc2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	44340882	9408	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	392	5	2	5	2.5	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]c(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL112150	9408	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	392	5	2	5	2.5	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]c(O)nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	155554837	174054	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL4558031	174054	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
	168283630	190685	0	None	-57	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	458	6	0	6	3.6	N#Cc1cccnc1N1CCN(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.ejmech.2022.114193
	CHEMBL5190788	190685	0	None	-57	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader methodDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method	ChEMBL	458	6	0	6	3.6	N#Cc1cccnc1N1CCN(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1016/j.ejmech.2022.114193
	49783209	17412	0	None	-10000	27	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human 5-HT7 receptorBinding affinity to human 5-HT7 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258223	17412	0	None	-10000	27	Human	5.2	pKi	=	5.2	Binding	Binding affinity to human 5-HT7 receptorBinding affinity to human 5-HT7 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	164618100	184768	0	None	-128	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	CHEMBL4860275	184768	0	None	-128	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2022.114645
	44437331	90518	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	CHEMBL239530	90518	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	734	21	0	8	8.2	COc1ccccc1N1CCN(CCc2cccc(OCCCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2007.05.010
	44424663	137603	0	None	-9	3	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	397	6	0	8	1.3	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL376773	137603	0	None	-9	3	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	397	6	0	8	1.3	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL4518342	212212	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7	ChEMBL		None	None	None		CC(C)CC(=O)N1CCc2nc(-c3ccc(Br)cc3)nc(N(C)Cc3ccccc3)c2C1	nan
	90654677	109596	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	484	6	1	5	3.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235749	109596	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	484	6	1	5	3.1	COc1ccccc1N1CCN(Cc2ccc(C(=O)N3Cc4ccccc4C[C@H]3C(N)=O)cc2)CC1	10.1016/j.ejmech.2014.03.005
	9978683	18472	0	None	-363	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
	CHEMBL1277104	18472	0	None	-363	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
	127041563	136467	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
	CHEMBL3746079	136467	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccc(F)cc1	10.1016/j.bmc.2015.11.041
	127041564	136514	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	7	0	6	2.9	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
	CHEMBL3746771	136514	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	434	7	0	6	2.9	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
	71453279	81006	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159475	81006	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	7	1	5	4.1	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(Cl)s1	10.1016/j.ejmech.2012.07.043
	145976292	163069	0	None	31	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	9	1	4	4.7	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
	CHEMBL4203908	163069	0	None	31	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	468	9	1	4	4.7	O=S(=O)(NC1CCN(CCCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
	155554837	174054	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL4558031	174054	0	None	-4	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	387	4	0	4	3.8	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cn2)CC1	10.1016/j.bmc.2020.115943
	155562543	174590	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL4570411	174590	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
	122178701	120840	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581246	120840	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	155562543	174590	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL4570411	174590	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	353	4	0	4	3.2	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccccn2)CC1	10.1016/j.bmc.2020.115943
	25263302	191377	0	None	-4466	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
	CHEMBL520129	191377	0	None	-4466	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
	56673112	66020	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851637	66020	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216275	66020	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	491	7	0	8	4.0	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccc(-c3ncccn3)cc2)CC1	10.1016/j.ejmech.2011.04.060
	44408988	165503	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	336	6	0	4	2.4	CN1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
	CHEMBL425767	165503	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	336	6	0	4	2.4	CN1CCN(CCCC2(S(=O)(=O)c3ccccc3)CCC2)CC1	10.1016/j.bmcl.2005.11.067
	155538814	172682	0	None	-38	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4524981	172682	0	None	-38	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3cccc(Cl)c3)n2)CC1	10.1016/j.ejmech.2019.06.022
	168283609	190633	0	None	-2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	418	10	5	8	3.1	COc1ccccc1NCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5190020	190633	0	None	-2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	418	10	5	8	3.1	COc1ccccc1NCCNc1nc(N)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	155544139	172771	0	None	-30	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(OCc2nc(N)nc(N3CCN(C)CC3)n2)ccc1Cl	10.1016/j.ejmech.2019.06.022
	CHEMBL4527124	172771	0	None	-30	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	1.7	Cc1cc(OCc2nc(N)nc(N3CCN(C)CC3)n2)ccc1Cl	10.1016/j.ejmech.2019.06.022
	122483228	137472	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764661	137472	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	155556527	173928	0	None	-7	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	247	2	1	2	3.3	CCn1cncc1-c1c[nH]c2ccc(F)c(F)c12	10.1016/j.ejmech.2019.03.017
	CHEMBL4555115	173928	0	None	-7	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	247	2	1	2	3.3	CCn1cncc1-c1c[nH]c2ccc(F)c(F)c12	10.1016/j.ejmech.2019.03.017
	72198014	89374	0	None	-18	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	484	7	2	4	4.8	COc1ccc2[nH]cc(C3CCN(CCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
	CHEMBL2377443	89374	0	None	-18	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	484	7	2	4	4.8	COc1ccc2[nH]cc(C3CCN(CCCN4C(=O)CC(c5c[nH]c6ccccc56)C4=O)CC3)c2c1	10.1016/j.ejmech.2013.02.033
	71458624	80941	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	3	4.5	Cc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159315	80941	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	400	7	1	3	4.5	Cc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
	145966199	163704	0	None	22	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	2	5	3.7	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
	CHEMBL4211665	163704	0	None	22	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	484	9	2	5	3.7	O=S(=O)(NC1CCN(CC(O)COc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2017.03.057
	44582675	189099	0	None	-81	16	Human	7.2	pKi	=	7.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL515472	189099	0	None	-81	16	Human	7.2	pKi	=	7.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	46206346	124076	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
	CHEMBL3640614	124076	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
	46206346	124076	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
	CHEMBL3640614	124076	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	351	4	1	3	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1OC1CCNCC1	nan
	10992240	53251	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
	CHEMBL160194	53251	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	368	8	1	5	3.6	COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1	10.1021/jm020994z
	25130235	186994	1	None	-169	11	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	186994	1	None	-169	11	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	122483228	137472	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764661	137472	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	164615340	184837	0	None	-25	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4861431	184837	0	None	-25	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1ccc(Cl)c(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	155530351	175700	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4464370	175700	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	CHEMBL4595115	175700	0	None	-6	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader methodDisplacement of [3H]5-CT from human 5HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta plate reader method	ChEMBL	517	8	0	4	5.8	O=S1(=O)c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1	10.1016/j.bmc.2019.06.028
	44393133	64502	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	CC(Nc1nccc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL182070	64502	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	318	7	2	4	4.3	CC(Nc1nccc(NCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	9945703	66333	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	CC(Nc1ccnc(NCCc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	CHEMBL185437	66333	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	336	7	2	4	4.4	CC(Nc1ccnc(NCCc2ccc(F)cc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.007
	2865	4064	67	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	59	4064	67	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	60854	4064	67	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	CHEMBL708	4064	67	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	DB00246	4064	67	None	-12	54	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5HT7 receptor (unknown origin) by radioligand binding assayBinding affinity to 5HT7 receptor (unknown origin) by radioligand binding assay	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm400856t
	44456033	155015	3	None	-4	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	C[C@@H]1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL404372	155015	3	None	-4	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	195	0	2	3	2.0	C[C@@H]1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.078
	10202089	194063	0	None	25	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	417	4	3	4	3.4	COc1ccccc1N1CCN(C(=O)NC(=N)NCc2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
	CHEMBL557330	194063	0	None	25	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	417	4	3	4	3.4	COc1ccccc1N1CCN(C(=O)NC(=N)NCc2cccc3ccccc23)CC1	10.1016/j.bmcl.2009.06.038
	145985585	165325	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4249640	165325	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	71451459	81018	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159487	81018	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CC[C@@H](NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	145946947	167030	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4176950	167030	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4300976	167030	0	None	31	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	452	8	2	6	2.0	CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	145947404	167098	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4163778	167098	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4301967	167098	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	468	8	2	7	1.7	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(c4ccccc4OC)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	138691314	164073	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4216263	164073	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
	138691314	164073	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1039/C8MD00313K
	CHEMBL4216263	164073	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1039/C8MD00313K
	155537034	171709	0	None	36	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	240	2	2	3	1.7	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
	CHEMBL4474827	171709	0	None	36	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	240	2	2	3	1.7	Cn1cncc1-c1c[nH]c2ccc(C(N)=O)cc12	10.1039/C8MD00313K
	127039755	136117	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	470	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1039/C5MD00166H
	CHEMBL3740055	136117	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	470	8	1	4	4.8	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc(Cl)c1	10.1039/C5MD00166H
	11151899	2097	10	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
	8432	2097	10	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
	CHEMBL4205783	2097	10	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1016/j.bmcl.2020.127669
	11323169	179377	0	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4746737	179377	0	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	56944953	159095	0	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4103725	159095	0	None	-2	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	463	7	2	3	4.9	O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	155563911	174833	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	534	10	1	7	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	CHEMBL4575904	174833	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	534	10	1	7	4.1	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1	10.1016/j.bmc.2019.07.046
	138691314	164073	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1021/acs.jmedchem.7b01898
	CHEMBL4216263	164073	1	None	173	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysisDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes by Cheng-Prusoff equation analysis	ChEMBL	337	2	1	2	3.7	CCn1cncc1-c1c[nH]c2ccc(I)cc12	10.1021/acs.jmedchem.7b01898
	11153067	76384	1	None	34	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	375	6	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC3CCCCC3C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206748	76384	1	None	34	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	375	6	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC3CCCCC3C2)CCC1	10.1016/j.bmcl.2005.11.067
	5	139	66	None	-3	55	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	5202	139	66	None	-3	55	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	CHEMBL39	139	66	None	-3	55	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	DB08839	139	66	None	-3	55	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2016.07.029
	25107516	186592	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	CHEMBL492282	186592	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	10.1021/jm800615e
	25256850	189131	0	None	44	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	364	7	1	4	3.3	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL515780	189131	0	None	44	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	364	7	1	4	3.3	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2009.02.008
	10917174	101699	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	439	7	1	3	5.6	C=CCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL302766	101699	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	439	7	1	3	5.6	C=CCn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	11397799	84295	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222864	84295	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	9881600	54896	3	None	8	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
	CHEMBL161765	54896	3	None	8	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	258	5	0	3	3.4	CN(C)CCSc1cccc(-c2ccccc2)n1	10.1016/j.bmc.2010.01.035
	24963856	87903	0	None	363	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	253	4	0	1	4.1	Cc1cccc(C)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL234881	87903	0	None	363	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	253	4	0	1	4.1	Cc1cccc(C)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	44401164	69458	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193639	69458	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	135398737	942	89	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	38	942	89	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	722	942	89	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	CHEMBL42	942	89	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	DB00363	942	89	None	-7	92	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030030n
	153287553	170528	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4457754	170528	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	66800991	111563	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	8	2.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	CHEMBL3289963	111563	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	456	7	1	8	2.4	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1cnc2ccccn12	10.1021/jm401895u
	66800910	111602	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	437	8	1	6	4.0	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3290000	111602	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	437	8	1	6	4.0	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1	10.1021/jm401895u
	1621	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	17	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	5761	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	CHEMBL263881	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	DB04829	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm0341204
	11307899	78443	0	None	-100	7	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	597	6	4	6	2.5	CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12	10.1021/jm0341204
	CHEMBL2112882	78443	0	None	-100	7	Human	8.2	pKi	=	8.2	Binding	Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors	ChEMBL	597	6	4	6	2.5	CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12	10.1021/jm0341204
	44341114	112878	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL331803	112878	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	476	6	2	3	5.1	O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1	10.1016/s0960-894x(02)00690-x
	133	2450	48	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	1723	2450	48	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	28693	2450	48	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	CHEMBL19215	2450	48	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	DB13520	2450	48	None	-16	43	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/s0960-894x(00)00166-9
	CHEMBL5081379	212964	0	None	1	9	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	134133064	144190	0	None	4	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
	CHEMBL3908870	144190	0	None	4	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
	153287553	170528	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4457754	170528	0	None	79	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	133	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	1723	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	28693	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	CHEMBL19215	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	DB13520	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.ejmech.2019.111705
	133	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	1723	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	28693	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	CHEMBL19215	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	DB13520	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1016/j.bmcl.2010.03.012
	133	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	1723	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	28693	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	CHEMBL19215	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	DB13520	2450	48	None	-10	43	Human	8.2	pKi	=	8.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1021/jm030841r
	22857296	28922	0	None	9	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	CHEMBL13816	28922	0	None	9	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	11465316	64916	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1016/j.bmcl.2004.11.013
	CHEMBL182792	64916	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1016/j.bmcl.2004.11.013
	11465316	64916	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	CHEMBL182792	64916	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	369	8	0	4	4.8	CCCN(CCC)[C@H]1COc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	9799318	106040	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL314055	106040	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	44341126	9363	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c[nH]nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL111922	9363	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3c[nH]nc3c2)CC1	10.1016/s0960-894x(02)00690-x
	44340883	9560	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]cnc3c2)CC1	10.1016/s0960-894x(02)00690-x
	CHEMBL112876	9560	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand	ChEMBL	376	5	1	4	2.8	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3[nH]cnc3c2)CC1	10.1016/s0960-894x(02)00690-x
	10884717	202560	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	441	5	1	4	5.1	CC(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL71225	202560	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	441	5	1	4	5.1	CC(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	162657983	180456	0	None	-26	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
	CHEMBL4759492	180456	0	None	-26	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2cc(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)ccc21	10.1016/j.ejmech.2020.112149
	9799318	106040	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1021/jm0498102
	CHEMBL314055	106040	0	None	-1	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	366	5	1	3	4.5	O=C1Nc2cccc3c2C1(CCCCN1CCc2sccc2C1)CCC3	10.1021/jm0498102
	134157171	153392	0	None	24	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	1	6	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccc(OC)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3983496	153392	0	None	24	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	531	14	1	6	5.3	COCOc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccc(OC)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	142601329	185925	3	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	185925	3	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	156010865	176547	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633786	176547	0	None	3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3	10.1016/j.bmc.2020.115578
	11151899	2097	10	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
	8432	2097	10	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
	CHEMBL4205783	2097	10	None	-5	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assayDisplacement of [3H]5-CT from rat 5-HT7 receptor expressed in HEK293 cell membranes by radioligand binding assay	ChEMBL	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	10.1021/acs.jmedchem.7b01898
	11186523	126976	0	None	-4	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL366164	126976	0	None	-4	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	24854269	157379	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	497	10	0	4	5.9	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)N(Cc2ccccc2)c2ccccc21	10.1021/jm070279v
	CHEMBL408451	157379	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	497	10	0	4	5.9	CCC1(CCCCN2CCN(c3ccccc3OC)CC2)C(=O)N(Cc2ccccc2)c2ccccc21	10.1021/jm070279v
	1621	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	17	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	5761	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	CHEMBL263881	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	DB04829	2386	16	None	-22	45	Human	8.2	pKi	=	8.2	Binding	Binding affinities towards 5-hydroxytryptamine 7 receptorBinding affinities towards 5-hydroxytryptamine 7 receptor	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	90656712	110468	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	399	5	2	3	5.0	CCc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262395	110468	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	399	5	2	3	5.0	CCc1[nH]c2ccc(O)cc2c1CCN1CCN(c2cccc3ccccc23)CC1	10.1016/j.ejmech.2014.04.034
	11432177	84684	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
	CHEMBL224820	84684	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/acs.jmedchem.5b00982
	44401164	69458	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL193639	69458	0	None	-30	9	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	142601329	185925	3	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	185925	3	None	61	7	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	11432177	84684	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL224820	84684	0	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	435	9	1	4	4.6	COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	54758298	65662	0	None	-4	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	CHEMBL1836857	65662	0	None	-4	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	401	6	1	3	4.5	O=C1Nc2cc(F)ccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1021/jm200547z
	56943599	111581	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL3289980	111581	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2cc(Cl)ccc2c1	10.1021/jm401895u
	CHEMBL5081379	212964	0	None	1	9	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	118728525	117204	0	None	-6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	420	9	0	6	3.8	CCOc1ccccc1N1CCN(CCCCCn2cnc3ccccc3c2=O)CC1	10.1016/j.bmcl.2015.02.042
	CHEMBL3401488	117204	0	None	-6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	420	9	0	6	3.8	CCOc1ccccc1N1CCN(CCCCCn2cnc3ccccc3c2=O)CC1	10.1016/j.bmcl.2015.02.042
	10562462	99218	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1021/jm9911433
	CHEMBL284586	99218	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1021/jm9911433
	76318011	105015	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	425	5	0	4	5.6	COc1ccccc1N1CCN(Cc2cn(-c3cccc(C)c3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121422	105015	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	425	5	0	4	5.6	COc1ccccc1N1CCN(Cc2cn(-c3cccc(C)c3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	60196079	81380	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	CHEMBL2164329	81380	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	252	2	1	2	3.1	Cc1ccccc1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	24854039	95310	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	CHEMBL258537	95310	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	394	7	1	2	5.5	CCC1(CCCCN2CCC(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21	10.1021/jm200547z
	56943891	111546	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289946	111546	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	498	8	1	6	4.5	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm401895u
	10562462	99218	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1016/s0960-894x(00)00655-7
	CHEMBL284586	99218	1	None	5	3	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	247	0	0	1	3.3	CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)C3	10.1016/s0960-894x(00)00655-7
	44266160	205761	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	421	4	0	3	3.3	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9446	205761	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	421	4	0	3	3.3	O=C1c2ccccc2CCCN1CCN1CCC(N2C(=O)Cc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	162661903	180836	0	None	-19	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
	CHEMBL4764006	180836	0	None	-19	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
	24854103	95695	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
	CHEMBL260551	95695	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
	44393001	64515	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	348	8	3	6	3.7	CC(Nc1nc(N)nc(NCCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182121	64515	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	348	8	3	6	3.7	CC(Nc1nc(N)nc(NCCCc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	71455083	81404	0	None	-100	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	CHEMBL2164354	81404	0	None	-100	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	22857296	28922	0	None	-9	4	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	CHEMBL13816	28922	0	None	-9	4	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm030030n
	11573726	71172	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926750	71172	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962912	71172	0	None	-7	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	76328896	105778	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121432	105778	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139016	105778	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	368	4	0	4	4.3	c1ccc(N2CCN(Cc3cn(-c4cccnc4)c4ccccc34)CC2)cc1	10.1016/j.ejmech.2014.01.055
	71458647	80987	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	9	1	4	4.0	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159457	80987	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	434	9	1	4	4.0	CC(C)c1ccccc1OCCN1CCC(CNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.ejmech.2012.07.043
	90644063	111530	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
	CHEMBL3289648	111530	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
	6918542	203206	20	None	-537	11	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00453-4
	CHEMBL76237	203206	20	None	-537	11	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 7 receptor	ChEMBL	358	6	0	5	3.0	COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00453-4
	156019939	177397	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
	CHEMBL4646100	177397	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	254	2	0	2	3.1	CN(C)[C@@H]1CCc2c(cccc2-c2cccn2C)C1	10.1016/j.bmc.2019.115262
	11575479	94292	0	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
	CHEMBL253096	94292	0	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptorDisplacement of [3H]LSD from human cloned 5HT7 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
	145978482	163068	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4203872	163068	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	436	8	1	4	4.2	O=S(=O)(NC1CCN(CCOc2cccc(-c3ccccc3)c2)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	168284975	190879	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	404	5	0	6	3.5	COc1cc2ncnc(N3CCC(CN4CCc5ccccc5C4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5193580	190879	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	404	5	0	6	3.5	COc1cc2ncnc(N3CCC(CN4CCc5ccccc5C4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	122483300	137549	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765794	137549	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765838	137549	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	57391158	71198	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949979	71198	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963033	71198	0	None	10	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	444	7	1	5	3.4	O=S(=O)(NCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.12.039
	122483300	137549	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765794	137549	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765838	137549	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	384	8	0	3	6.1	CN(CCCCCC(=O)n1c2ccccc2c2ccccc21)Cc1ccccc1	10.1016/j.ejmech.2016.01.043
	168277374	189765	0	None	9	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	441	8	4	6	4.6	Nc1nc(NCCc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5177186	189765	0	None	9	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	441	8	4	6	4.6	Nc1nc(NCCc2cccc(Cl)c2Cl)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	168291906	191422	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	452	8	0	5	4.8	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
	CHEMBL5201984	191422	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	452	8	0	5	4.8	O=c1n(CCCCCCN2CCN(c3cccc(Cl)c3)CC2)c2cccc3c2n1CCC3	10.1016/j.ejmech.2022.114319
	66803500	155886	0	None	-24	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	459	8	3	4	4.4	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4066971	155886	0	None	-24	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	459	8	3	4	4.4	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1	10.1021/acs.jmedchem.7b00839
	118736396	118432	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	6	0	10	1.3	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	CHEMBL3423378	118432	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	6	0	10	1.3	Cn1c(=O)c2c(nc3n(CCCCN4CCN(c5ccc(Cl)cc5)CC4)c(=O)ccn23)n(C)c1=O	10.1016/j.ejmech.2015.04.046
	162642955	181147	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4777209	181147	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	468	9	0	4	6.1	COc1ccc(-c2ccccc2N2CCN(CCCCOc3ccc(Cl)c(F)c3)CC2)cc1	10.1016/j.ejmech.2020.112395
	163196460	192080	3	None	-56	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	394	4	1	7	3.4	CN1CCN(c2nc(N)nc(C(C)(C)Sc3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2022.114645
	CHEMBL5219240	192080	3	None	-56	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay	ChEMBL	394	4	1	7	3.4	CN1CCN(c2nc(N)nc(C(C)(C)Sc3ccc4ccccc4c3)n2)CC1	10.1016/j.ejmech.2022.114645
	66801837	156974	0	None	-6	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	507	8	2	3	6.1	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	CHEMBL4079972	156974	0	None	-6	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	507	8	2	3	6.1	Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(CCCCNS(=O)(=O)c2ccc3ccccc3c2)CC1	10.1021/acs.jmedchem.7b00839
	2867758	161481	7	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	339	6	1	2	5.5	Cc1ccc(C(C)(C)CC(C)NCc2ccc(C(F)(F)F)cc2)o1	10.1016/j.ejmech.2018.04.010
	CHEMBL4160177	161481	7	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	339	6	1	2	5.5	Cc1ccc(C(C)(C)CC(C)NCc2ccc(C(F)(F)F)cc2)o1	10.1016/j.ejmech.2018.04.010
	53377139	66033	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851703	66033	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3216068	66033	0	None	-21	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	413	6	0	6	3.5	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2011.04.060
	134130379	141661	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	8	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884137	141661	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	402	8	0	5	3.9	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2016.12.039
	155568224	175537	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	350	4	1	7	2.2	CN1CCN(c2nc(N)nc(CSc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4591878	175537	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	350	4	1	7	2.2	CN1CCN(c2nc(N)nc(CSc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	122483251	137562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764364	137562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765851	137562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	122483251	137562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764364	137562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765851	137562	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	362	6	0	3	5.9	O=C(CCCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	76328894	105780	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121431	105780	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139018	105780	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	398	5	0	5	4.4	COc1ccccc1N1CCN(Cc2cn(-c3ccccn3)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	164620912	185143	0	None	-7	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	1	4	2.6	OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4866053	185143	0	None	-7	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	341	4	1	4	2.6	OC1c2ccc(F)cc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	118709755	113034	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	368	8	0	2	5.0	O=C1Cc2ccccc2N1CCCCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	CHEMBL3321797	113034	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	368	8	0	2	5.0	O=C1Cc2ccccc2N1CCCCCCCN1CC[C@H]2CCCC[C@@H]2C1	10.1021/jm500880c
	135398737	942	89	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	38	942	89	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	722	942	89	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	CHEMBL42	942	89	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	DB00363	942	89	None	-7	92	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2015.09.045
	60165412	74994	0	None	-17	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	379	7	0	5	4.5	O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037530	74994	0	None	-17	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	379	7	0	5	4.5	O=C(CCCCN1CCN(c2ccccc2)CC1)c1nc2ccccc2s1	10.1016/j.ejmech.2012.03.042
	162666571	181715	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CC(C)(C)CCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4784167	181715	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	460	10	0	6	5.2	COc1ccc(-c2ccccc2N2CCN(CC(C)(C)CCCOc3cnccn3)CC2)cc1	10.1016/j.ejmech.2020.112395
	44582707	186405	0	None	-52	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490634	186405	0	None	-52	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	155519559	169802	0	None	-3162	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1ccc2cccnc2c1	10.1021/acsmedchemlett.6b00056
	CHEMBL4447846	169802	0	None	-3162	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1ccc2cccnc2c1	10.1021/acsmedchemlett.6b00056
	71452382	83366	0	None	-199	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205812	83366	0	None	-199	10	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
	127051516	140313	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3819567	140313	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
	164619216	185072	0	None	-74	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4864863	185072	0	None	-74	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	424	7	1	7	3.8	CCCCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	118724645	120076	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3361003	120076	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3545907	120076	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	367	5	0	7	1.3	Cn1c(=O)c2c(ncn2CCCCN2CCc3ccccc3C2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	2470	3583	46	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3583	46	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3583	46	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3583	46	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3583	46	None	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	122181345	121360	0	None	-1	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCCC3c3ccccc3)C2=O)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590097	121360	0	None	-1	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	490	8	1	5	4.2	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCCCC3c3ccccc3)C2=O)CC1	10.1016/j.bmc.2015.04.026
	11566574	71126	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926753	71126	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962487	71126	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	355	6	1	4	2.0	O=C1C2CCCN2C(=O)N1C/C=C/CNCC1CCc2ccccc2O1	10.1021/jm2007886
	25125374	177302	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	4.8	CN(C)C1CCc2c(cccc2-c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4644725	177302	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	319	2	0	1	4.8	CN(C)C1CCc2c(cccc2-c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
	164627977	185841	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4876297	185841	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	156022183	177623	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	2	1	2	3.8	CCCN1CCc2cccc3c2C1Cc1ccc(N)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4649646	177623	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	278	2	1	2	3.8	CCCN1CCc2cccc3c2C1Cc1ccc(N)cc1-3	10.1016/j.bmc.2020.115578
	42626361	186187	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1Cc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL489029	186187	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	363	7	0	3	3.6	O=C1Cc2ccccc2N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	42625353	192453	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	393	8	0	4	3.6	COc1ccccc1N1CCN(CCCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
	CHEMBL522417	192453	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	393	8	0	4	3.6	COc1ccccc1N1CCN(CCCCCN2C(=O)Cc3ccccc32)CC1	10.1021/jm8014553
	11348477	126252	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C/CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL365412	126252	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C/CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	10991109	203446	1	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	329	5	0	2	4.1	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
	CHEMBL78218	203446	1	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	329	5	0	2	4.1	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(F)cc2)CC1	10.1021/jm0200411
	9979252	98052	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL276206	98052	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/s0960-894x(00)00166-9
	10436045	3447	3	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	782	3447	3	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	CHEMBL432713	3447	3	None	-19	13	Human	7.2	pKi	=	7.2	Binding	Binding affinity for 5-hydroxytryptamine 7 receptor was determinedBinding affinity for 5-hydroxytryptamine 7 receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	49850872	56149	0	None	-251	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1632206	56149	0	None	-251	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	90656714	110465	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262390	110465	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	37459	733	10	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
	62	733	10	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
	CHEMBL8514	733	10	None	-194	25	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/s0960-894x(00)00166-9
	135	2486	38	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	1796	2486	38	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	4184	2486	38	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	CHEMBL6437	2486	38	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	DB06148	2486	38	None	-50	58	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1016/s0960-894x(00)00166-9
	9979252	98052	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	CHEMBL276206	98052	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	415	7	0	4	4.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1021/jm030841r
	44268087	19979	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	CHEMBL13049	19979	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	44268087	19979	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL13049	19979	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	117209912	184745	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	184745	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	164627977	185841	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4876297	185841	0	None	-12	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	355	4	0	4	3.3	O=C1c2cc(Cl)ccc2CC1CCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL5077178	212706	0	None	-4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1ccc(F)cc1	10.1021/acs.jmedchem.1c00497
	90644063	111530	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
	CHEMBL3289648	111530	0	None	-2	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2020.115943
	90656714	110465	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262390	110465	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	321	4	2	3	3.2	Oc1ccc2[nH]cc(CCN3CCN(c4ccccc4)CC3)c2c1	10.1016/j.ejmech.2014.04.034
	242	467	117	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	34	467	117	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	60795	467	117	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	CHEMBL1112	467	117	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	DB01238	467	117	None	-15	52	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	2337	3193	72	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	50	3193	72	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	5002	3193	72	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	CHEMBL716	3193	72	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	DB01224	3193	72	None	-28	63	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	9887537	83913	38	None	-79	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	CHEMBL221692	83913	38	None	-79	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	CHEMBL4751170	83913	38	None	-79	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	135	2486	38	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	1796	2486	38	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	4184	2486	38	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	CHEMBL6437	2486	38	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	DB06148	2486	38	None	-83	58	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030841r
	37461	16938	10	None	-70	8	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm030841r
	CHEMBL1255588	16938	10	None	-70	8	Human	7.2	pKi	=	7.2	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm030841r
	90656688	110485	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	338	7	2	4	2.4	NC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262420	110485	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	338	7	2	4	2.4	NC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	11329254	84778	0	None	2	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL225571	84778	0	None	2	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	450	9	1	5	4.5	O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	17053	200353	5	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	244	4	1	2	2.8	COc1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1021/jm030826m
	CHEMBL608537	200353	5	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	244	4	1	2	2.8	COc1ccc2[nH]cc(CCN3CCCC3)c2c1	10.1021/jm030826m
	11485965	45567	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	385	6	0	3	4.4	O=C1c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	CHEMBL153132	45567	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	385	6	0	3	4.4	O=C1c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	11793826	17853	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	CHEMBL12654	17853	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CTBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor expressed in HEK 293 cells using [3H]5-CT	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm970519e
	11793826	17853	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	CHEMBL12654	17853	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cellsBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor in HEK 293 cells	ChEMBL	374	6	0	3	4.0	C[C@H]1CCCN(CC[C@@H](C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1016/s0960-894x(00)00166-9
	44368384	44140	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	CHEMBL151858	44140	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand	ChEMBL	373	6	0	3	4.8	CC([C@H](C)CCN1CCC[C@H](C)C1)S(=O)(=O)c1cccc2ccccc12	10.1021/jm030841r
	127051516	140313	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
	CHEMBL3819567	140313	0	None	-26	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	420	6	1	5	4.0	O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3ccccc3s1)CC2	10.1016/j.bmc.2016.06.011
	9935387	98970	0	None	-794	14	Human	6.2	pKi	=	6.2	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL282971	98970	0	None	-794	14	Human	6.2	pKi	=	6.2	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 7 receptor in HEK293 cells, using [3H]5-CT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
	90654693	109577	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	388	8	1	5	1.5	COc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235730	109577	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	388	8	1	5	1.5	COc1ccccc1N1CCN(CCCCC(=O)N2CCC[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	156010396	176543	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	392	5	1	4	4.2	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4633765	176543	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	392	5	1	4	4.2	COc1cc2c3c(c1OCC1CC1)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	71457264	82195	0	None	-20	6	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	447	5	1	6	4.4	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
	CHEMBL2179217	82195	0	None	-20	6	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	447	5	1	6	4.4	COc1ccc(S(=O)(=O)n2cc(C)c3cc(Cl)ccc32)cc1NC1CCN(C)CC1	10.1021/jm300955x
	2136365	117411	21	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	0	5	4.5	Cc1ccc(S(=O)(=O)c2nc(N3CCc4ccccc4C3)sc2Cl)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403331	117411	21	None	-5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	404	3	0	5	4.5	Cc1ccc(S(=O)(=O)c2nc(N3CCc4ccccc4C3)sc2Cl)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL5090884	213791	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096072	213791	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	11610908	67686	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1914488	67686	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	394	7	1	3	4.0	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	145977467	163428	0	None	9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4208185	163428	0	None	9	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	486	7	1	4	3.1	O=S(=O)(NC1CCN(CCOc2ccccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	117209912	184745	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4859827	184745	1	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	262	2	2	3	2.1	Clc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	11432453	84759	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	CHEMBL225441	84759	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	451	9	1	5	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3cccc(OC)c32)CC1	10.1021/jm049702f
	76324975	104523	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3cccnc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113604	104523	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	473	11	1	6	4.2	COc1ccc(CNC(=O)CCCCCN2CCN(c3cccnc3-c3ccncc3)CC2)cc1	10.1016/j.bmc.2014.01.016
	72549768	113561	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	443	9	1	4	4.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326977	113561	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	443	9	1	4	4.6	COc1ccccc1N1CCN(CCCC(=O)NCc2ccccc2-c2ccccc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL5090884	213791	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096072	213791	0	None	1	7	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	162644013	181247	0	None	-16	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
	CHEMBL4778418	181247	0	None	-16	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	473	7	1	6	4.5	Cc1c(S(=O)(=O)N[C@H]2CCN(CCCc3noc4ccccc34)C2)sc2ccc(F)cc12	10.1016/j.ejmech.2020.112149
	162666577	181741	0	None	-47	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
	CHEMBL4784414	181741	0	None	-47	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	455	7	1	6	4.3	Cc1ccc2sc(S(=O)(=O)N[C@H]3CCN(CCCc4noc5ccccc45)C3)cc2c1	10.1016/j.ejmech.2020.112149
	155562519	174630	0	None	-131	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccc(F)cc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
	CHEMBL4571321	174630	0	None	-131	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method	ChEMBL	516	8	2	4	5.3	COc1ccc2[nH]cc(C3CC(=O)N(CCCCN4CCC(c5c[nH]c6ccc(F)cc56)CC4)C3=O)c2c1	10.1016/j.ejmech.2019.111736
	155541072	172385	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	290	3	2	4	1.7	CCn1cncc1-c1c[nH]c2ccc(S(N)(=O)=O)cc12	10.1039/C8MD00313K
	CHEMBL4517552	172385	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7b receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	290	3	2	4	1.7	CCn1cncc1-c1c[nH]c2ccc(S(N)(=O)=O)cc12	10.1039/C8MD00313K
	134134279	143110	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	257	5	1	3	3.1	CNCc1ccc(OC)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	CHEMBL3899934	143110	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	257	5	1	3	3.1	CNCc1ccc(OC)c(-c2ccccc2OC)c1	10.1016/j.ejmech.2016.07.029
	76332575	105782	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
	CHEMBL3121416	105782	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
	CHEMBL3139020	105782	0	None	-4	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	314	4	0	2	4.9	CN(C)CCc1cn(-c2cccc3ccccc23)c2ccccc12	10.1016/j.ejmech.2014.01.055
	44268087	19979	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	CHEMBL13049	19979	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	374	6	0	3	4.0	CC1CCCN(CCC(C)N(C)S(=O)(=O)c2cccc3ccccc23)C1	10.1021/jm030030n
	76328898	105922	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121440	105922	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139518	105922	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1cccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.ejmech.2014.01.055
	145983144	165316	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4249426	165316	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	134154387	151916	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
	CHEMBL3970994	151916	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
	56944863	156166	0	None	-64	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4070254	156166	0	None	-64	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.7b00839
	155540635	171953	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	431	7	1	4	5.4	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4483687	171953	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	431	7	1	4	5.4	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	11431530	84188	0	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL222188	84188	0	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	405	8	1	3	4.6	O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	168269921	189477	0	None	-218	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	430	8	0	7	3.4	O=c1n(CCCCCCN2CCN(c3cccc4cccnc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	CHEMBL5172673	189477	0	None	-218	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay	ChEMBL	430	8	0	7	3.4	O=c1n(CCCCCCN2CCN(c3cccc4cccnc34)CC2)nc2ccccn12	10.1016/j.ejmech.2022.114319
	21527771	69798	0	None	-263	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940404	69798	0	None	-263	10	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	71602687	89240	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376456	89240	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
	56850656	71139	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926744	71139	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962584	71139	0	None	-27	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	7	1	4	2.6	O=C1C2CCCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	118626088	164838	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4238124	164838	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	508	6	0	7	3.4	O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2018.01.002
	134154387	151916	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
	CHEMBL3970994	151916	0	None	1	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	289	3	0	1	4.5	C1=C(CCN2CCc3ccccc3C2)CCc2ccccc21	10.1016/j.bmc.2016.09.019
	72548349	113575	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(C)cc2)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326991	113575	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	471	10	1	4	5.3	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccc(C)cc2)CC1	10.1016/j.bmc.2014.07.026
	76284725	104521	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2cccnc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113602	104521	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2cccnc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	168295509	191906	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5209283	191906	0	None	-5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	71602687	89240	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
	CHEMBL2376456	89240	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	376	5	0	3	4.8	COc1ccccc1N1CCN(Cc2ccccc2-c2ccccc2F)CC1	10.1016/j.bmc.2013.02.038
	53323534	56713	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(Cn2cc(-c3ccccc3)c3c2CCNC3)c1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644485	56713	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1cccc(Cn2cc(-c3ccccc3)c3c2CCNC3)c1	10.1016/j.bmcl.2010.11.078
	46205042	124044	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
	CHEMBL3640583	124044	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
	46205042	124044	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
	CHEMBL3640583	124044	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	5	1	3	3.9	Cc1ccccc1-c1ccc(OC2CCC2)c(OC2CNC2)c1	nan
	155515942	169431	0	None	-331	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	389	3	1	5	3.8	O=S(=O)(c1ccc2ncccc2c1)n1cc(C2=CCNCC2)c2ccccc21	10.1021/acsmedchemlett.6b00056
	CHEMBL4442456	169431	0	None	-331	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	389	3	1	5	3.8	O=S(=O)(c1ccc2ncccc2c1)n1cc(C2=CCNCC2)c2ccccc21	10.1021/acsmedchemlett.6b00056
	46233382	198989	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	271	6	0	3	3.3	COc1ccccc1-c1ccccc1OCCN(C)C	10.1016/j.bmc.2010.01.035
	CHEMBL599819	198989	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	271	6	0	3	3.3	COc1ccccc1-c1ccccc1OCCN(C)C	10.1016/j.bmc.2010.01.035
	46204425	124032	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640572	124032	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
	46204425	124032	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
	CHEMBL3640572	124032	1	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1ccccc1-c1cccc(OC2CNC2)c1	nan
	122181335	121350	0	None	-11	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	486	6	1	4	4.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590087	121350	0	None	-11	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	486	6	1	4	4.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2015.04.026
	145976408	163315	0	None	10	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	424	5	1	4	3.4	O=C1Nc2ccccc2C12CCN(CCCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	CHEMBL4206881	163315	0	None	10	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis	ChEMBL	424	5	1	4	3.4	O=C1Nc2ccccc2C12CCN(CCCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmcl.2018.06.019
	145964621	163774	0	None	18	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4212539	163774	0	None	18	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	516	7	1	4	4.0	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Br)c1	10.1021/acs.jmedchem.8b00828
	134154680	154013	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3959919	154013	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3991166	154013	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	156022234	177626	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	380	5	1	4	4.2	CCCC(=O)Nc1ccc2c(c1)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	CHEMBL4649697	177626	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	380	5	1	4	4.2	CCCC(=O)Nc1ccc2c(c1)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmc.2020.115578
	181743	177987	3	None	-33	22	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	CHEMBL467094	177987	3	None	-33	22	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	56944086	111577	0	None	-12	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	420	8	1	7	2.8	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289976	111577	0	None	-12	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	420	8	1	7	2.8	O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	134154680	154013	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3959919	154013	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL3991166	154013	0	None	-9	9	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	416	7	0	5	5.3	COc1cc2c(cc1OC)CN(CCCCc1nc3cc(Cl)ccc3s1)CC2	10.1016/j.bmc.2016.09.019
	CHEMBL5082267	213013	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		O=S(=O)(CC1CCN(CCCc2noc3cc(F)ccc23)C1)c1cccc(C(F)(F)F)c1	10.1021/acs.jmedchem.1c00497
	145984807	165212	0	None	-134	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	CHEMBL4247275	165212	0	None	-134	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	1	7	3.0	O=c1[nH]c2c(N3CCN(CC[C@@H]4CCCN4S(=O)(=O)c4cncc5ccccc45)CC3)cccc2o1	10.1016/j.ejmech.2018.01.002
	122483230	137547	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765223	137547	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765836	137547	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	10150497	3999	41	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	3240	3999	41	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	CHEMBL392760	3999	41	None	-331	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	11494176	71160	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926735	71160	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962803	71160	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNC[C@@H]1CCc2ccccc2O1	10.1021/jm2007886
	127041261	136461	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1	10.1016/j.bmc.2015.11.041
	CHEMBL3745975	136461	0	None	4	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	448	7	0	4	4.3	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1cccc(F)c1	10.1016/j.bmc.2015.11.041
	57391622	71208	0	None	3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1949970	71208	0	None	3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	CHEMBL1963100	71208	0	None	3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2ccc(Cl)cc2)CC1)c1cncc2ccccc12	10.1016/j.bmc.2011.12.039
	42625181	192554	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	403	7	1	4	3.4	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3[nH]cnc23)CC1	10.1021/jm8014553
	CHEMBL523121	192554	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	403	7	1	4	3.4	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3[nH]cnc23)CC1	10.1021/jm8014553
	118728513	117192	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4cccc(Cl)c4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401476	117192	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	1	5	4.8	Cc1sc2nc(CCCCCN3CCN(c4cccc(Cl)c4)CC3)[nH]c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	44424660	85334	0	None	-11	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	454	9	0	9	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL229311	85334	0	None	-11	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	454	9	0	9	1.8	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	122483230	137547	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765223	137547	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765836	137547	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	350	9	0	3	5.7	CCCCN(C)CCCCCC(=O)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	44374226	54254	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	188	4	0	4	1.8	CN(C)CCSc1nccs1	10.1016/j.bmcl.2003.11.050
	CHEMBL161031	54254	1	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	188	4	0	4	1.8	CN(C)CCSc1nccs1	10.1016/j.bmcl.2003.11.050
	11101259	51292	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	392	8	2	5	3.8	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)c1ccccc1O	10.1021/jm020994z
	CHEMBL158332	51292	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	392	8	2	5	3.8	O=C(CCCCCN1CCN(c2nc3ccccc3[nH]2)CC1)c1ccccc1O	10.1021/jm020994z
	71452383	83368	0	None	-3	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	339	5	1	4	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205814	83368	0	None	-3	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5-HT7 receptorBinding affinity to 5-HT7 receptor	ChEMBL	339	5	1	4	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
	145983751	164942	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1ccnc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4240642	164942	0	None	-13	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	521	6	0	7	4.6	O=S(=O)(c1ccnc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	66801537	157377	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4084492	157377	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	465	6	2	3	5.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	57400281	71193	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949965	71193	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963028	71193	0	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	458	8	1	5	3.8	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccc2ncccc2c1	10.1016/j.bmc.2011.12.039
	122178698	120838	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	CHEMBL3581244	120838	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/np500893h
	42625183	186407	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C/CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	CHEMBL490645	186407	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	397	5	0	3	4.1	O=C1Cc2ccccc2N1C/C=C/CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	42625446	188261	0	None	-4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	413	7	0	3	4.7	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	CHEMBL506875	188261	0	None	-4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	413	7	0	3	4.7	O=C1Cc2ccccc2N1CCCCCN1CCN(c2cccc3ccccc23)CC1	10.1021/jm8014553
	24771120	183508	0	None	-3019	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
	CHEMBL482562	183508	0	None	-3019	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
	134150597	151521	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	339	4	0	4	4.3	COc1ccccc1-c1cc(CN2CCC(C)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3967387	151521	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	339	4	0	4	4.3	COc1ccccc1-c1cc(CN2CCC(C)CC2)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	118736372	118426	0	None	-11	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	7	0	9	2.6	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
	CHEMBL3423336	118426	0	None	-11	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based methodDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHOK1 cells incubated for 60 mins by microbeta plate reader based method	ChEMBL	497	7	0	9	2.6	Cc1cn2c3c(=O)n(C)c(=O)n(C)c3nc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2015.04.046
	153061504	172231	0	None	-34	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4513930	172231	0	None	-34	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	155533028	171220	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	458	9	0	5	5.1	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4468036	171220	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	458	9	0	5	5.1	O=C1c2cccc3cccc(c23)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4520788	212215	6	None	-32	25	Human	6.2	pKi	=	6.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	nan
	10090247	203848	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	CHEMBL81276	203848	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1021/jm030030n
	10090247	203848	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL81276	203848	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	365	3	0	3	4.2	FC(F)(F)c1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	127026753	137187	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758978	137187	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	392	8	1	4	3.0	CC(C)c1ccccc1OCCN1CC(NS(=O)(=O)c2ccc(F)cc2)C1	10.1016/j.ejmech.2015.11.040
	127042185	136530	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	454	8	0	6	3.3	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
	CHEMBL3747003	136530	0	None	4	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	454	8	0	6	3.3	CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1cnn(C)c1	10.1016/j.bmc.2015.11.041
	145985533	165168	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4246202	165168	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	145983139	165300	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4249179	165300	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	491	6	0	7	3.7	O=S(=O)(c1cccc2ncccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	71449629	80948	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159321	80948	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	428	8	1	5	4.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(Cl)s2)C1	10.1016/j.ejmech.2012.07.043
	71455000	80997	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159466	80997	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	71449643	81012	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159481	81012	0	None	3	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	145947300	167091	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4170613	167091	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4301924	167091	0	None	19	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	511	6	2	6	2.3	CC1(c2ccc(Br)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	156011936	176818	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	435	8	1	6	4.3	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4638308	176818	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	435	8	1	6	4.3	O=c1[nH]c2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	156019026	177212	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	7	4.6	O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4643450	177212	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	7	4.6	O=c1oc2ccccc2n1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	60195996	81388	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	CHEMBL2164338	81388	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	283	3	1	4	2.7	O=[N+]([O-])c1ccc(-c2ccccc2N2CCNCC2)cc1	10.1021/jm3003679
	71455000	80997	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1039/C5MD00166H
	CHEMBL2159466	80997	0	None	8	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1039/C5MD00166H
	127038033	136070	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3ncccc23)CC1	10.1039/C5MD00166H
	CHEMBL3739680	136070	0	None	14	4	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	453	8	1	5	4.2	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3ncccc23)CC1	10.1039/C5MD00166H
	127039756	136192	0	None	25	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cc(F)ccc1F	10.1039/C5MD00166H
	CHEMBL3740801	136192	0	None	25	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	472	8	1	4	4.5	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cc(F)ccc1F	10.1039/C5MD00166H
	127039753	136206	0	None	22	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1039/C5MD00166H
	CHEMBL3740913	136206	0	None	22	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	454	8	1	4	4.3	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1	10.1039/C5MD00166H
	42625440	170236	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
	CHEMBL445334	170236	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1016/j.ejmech.2014.08.023
	25256855	189156	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL515939	189156	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.ejmech.2014.08.023
	21048816	75134	0	None	30	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	385	7	0	3	4.9	CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL204269	75134	0	None	30	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	385	7	0	3	4.9	CC(C)(CCCN1CCCC(c2ccccc2)C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	11589069	95787	0	None	10	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	CHEMBL260994	95787	0	None	10	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm200547z
	42625440	170236	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm500880c
	CHEMBL445334	170236	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm500880c
	42625440	170236	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	CHEMBL445334	170236	0	None	30	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	320	5	0	2	3.4	O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1	10.1021/jm8014553
	25256855	189156	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL515939	189156	0	None	64	3	Human	8.2	pKi	=	8.2	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	398	7	1	4	4.0	O=c1[nH]c2ccccc2n1CCCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2009.02.008
	11145126	202686	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	5	1	4	4.9	CN(C)C(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL71959	202686	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	470	5	1	4	4.9	CN(C)C(=O)n1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	60196077	81393	0	None	20	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	CHEMBL2164343	81393	0	None	20	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	132525569	163486	0	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	272	3	0	5	2.1	CCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
	CHEMBL4208934	163486	0	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes	ChEMBL	272	3	0	5	2.1	CCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1	10.1021/acs.jmedchem.7b01898
	24768516	92140	0	None	11	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL243523	92140	0	None	11	4	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	44374207	52203	0	None	5	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	280	5	1	4	2.9	CN(C)CCSc1cccc(C2(O)CCCCC2)n1	10.1016/j.bmcl.2003.11.050
	CHEMBL159143	52203	0	None	5	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	280	5	1	4	2.9	CN(C)CCSc1cccc(C2(O)CCCCC2)n1	10.1016/j.bmcl.2003.11.050
	9911844	119352	0	None	43	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/j.ejmech.2019.111705
	CHEMBL348890	119352	0	None	43	2	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/j.ejmech.2019.111705
	9911844	119352	0	None	43	2	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL348890	119352	0	None	43	2	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	9911844	119352	0	None	43	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cellBinding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	CHEMBL348890	119352	0	None	43	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cellBinding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1016/s0960-894x(02)00842-9
	162654006	179898	0	None	-29	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
	CHEMBL4753094	179898	0	None	-29	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	425	7	1	6	3.6	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccccc2o1	10.1016/j.ejmech.2020.112149
	162643812	181071	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
	CHEMBL4776225	181071	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	435	7	1	5	4.0	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12	10.1016/j.ejmech.2020.112149
	9911844	119352	0	None	43	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1021/jm070279v
	CHEMBL348890	119352	0	None	43	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	454	6	1	2	6.5	O=C1Nc2ccc(Cl)c3c2C1(CCCCN1CC=C(c2ccc(Cl)cc2)CC1)CCC3	10.1021/jm070279v
	10873805	202978	2	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1	10.1021/jm0200411
	CHEMBL73979	202978	2	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2ccc(I)cc2)CC1	10.1021/jm0200411
	5	139	66	None	-5	55	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
	5202	139	66	None	-5	55	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
	CHEMBL39	139	66	None	-5	55	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
	DB08839	139	66	None	-5	55	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.05.010
	35985234	87904	10	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	211	3	1	1	3.2	Cc1ccccc1-c1cccc(CCN)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL234885	87904	10	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	211	3	1	1	3.2	Cc1ccccc1-c1cccc(CCN)c1	10.1016/j.bmcl.2007.03.054
	145976433	163367	0	None	2	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	372	6	0	3	4.7	COc1cccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)c1	10.1021/acs.jmedchem.7b01898
	CHEMBL4207454	163367	0	None	2	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]lysergide from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay	ChEMBL	372	6	0	3	4.7	COc1cccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)c1	10.1021/acs.jmedchem.7b01898
	155522867	170249	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	401	8	1	6	3.5	COC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
	CHEMBL4453552	170249	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	401	8	1	6	3.5	COC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2019.111690
	118713686	113879	0	None	-28	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	5	4.8	O=c1sc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331389	113879	0	None	-28	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	409	9	0	5	4.8	O=c1sc2ccccc2n1CCCCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	168271960	189505	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5173014	189505	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	368	6	0	3	3.5	CC1CCN(CCC[C@H]2CCCN2S(=O)(=O)c2ccccc2F)CC1	10.1021/acs.jmedchem.2c00633
	11395034	71140	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926751	71140	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962585	71140	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	16747715	150499	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmc.2010.01.035
	CHEMBL395870	150499	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmc.2010.01.035
	16747715	150499	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL395870	150499	0	None	58	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	239	4	0	1	3.8	Cc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	11515799	156385	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	348	6	1	2	4.5	CCC1(CCCCN2CCc3ccccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
	CHEMBL407263	156385	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	348	6	1	2	4.5	CCC1(CCCCN2CCc3ccccc3C2)C(=O)Nc2ccccc21	10.1021/jm070279v
	136152971	94900	0	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	CHEMBL256694	94900	0	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	293	2	2	3	3.5	C[C@@H]1NC(NCC(F)F)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.078
	118713687	113881	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	423	10	0	6	4.4	COc1ccccc1N1CCN(CCCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331390	113881	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	423	10	0	6	4.4	COc1ccccc1N1CCN(CCCCCCCn2c(=O)oc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	164621627	184891	0	None	-10	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4862180	184891	0	None	-10	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	118713588	113861	0	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	397	7	0	6	3.7	COc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331257	113861	0	None	3	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	397	7	0	6	3.7	COc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	10429067	123100	0	None	43	6	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	CHEMBL361875	123100	0	None	43	6	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	10429067	123100	0	None	43	6	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	CHEMBL361875	123100	0	None	43	6	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]5-HT binding to rat 5-HT7 receptorInhibition of [3H]5-HT binding to rat 5-HT7 receptor	ChEMBL	367	8	0	3	5.4	CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1	10.1021/jm0498102
	10257	726	28	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
	144	726	28	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
	CHEMBL416526	726	28	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
	DB01445	726	28	None	-3	19	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	10.1021/jm030826m
	10884517	101770	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	1	4	4.4	CC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL303166	101770	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	431	7	1	4	4.4	CC(=O)c1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	206	2447	10	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
	68848	2447	10	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
	CHEMBL12314	2447	10	None	-6	25	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/s0960-894x(00)00166-9
	11391654	179933	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	179933	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	5	139	66	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
	5202	139	66	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
	CHEMBL39	139	66	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
	DB08839	139	66	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111705
	9954003	71341	18	None	-15	9	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
	CHEMBL196514	71341	18	None	-15	9	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
	197033	197463	58	None	3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	CHEMBL589390	197463	58	None	3	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2009.11.037
	206	2447	10	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
	68848	2447	10	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
	CHEMBL12314	2447	10	None	-10	25	Human	8.1	pKi	=	8.1	Binding	Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1021/jm030841r
	46205374	124055	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
	CHEMBL3640594	124055	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
	168268877	189367	0	None	-1	12	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189367	0	None	-1	12	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	46205374	124055	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
	CHEMBL3640594	124055	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	321	3	1	2	4.5	COc1ccc(-c2ccccc2C(F)(F)F)cc1C1CCNC1	nan
	100	3733	52	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	2637	3733	52	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	5452	3733	52	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	CHEMBL479	3733	52	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	DB00679	3733	52	None	-28	56	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm030030n
	44460917	103918	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	297	4	0	3	3.3	C=C(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL310317	103918	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	297	4	0	3	3.3	C=C(C)c1ccc2ccn(CCN3CCCN(C)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	44460980	204214	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2ccn(CCN3CCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL84270	204214	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	361	3	0	3	3.6	Brc1ccc2ccn(CCN3CCN4CCCCC4C3)c2c1	10.1016/s0960-894x(02)00438-9
	76321737	105925	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3121428	105925	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	CHEMBL3139525	105925	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	397	5	0	4	5.0	COc1ccccc1-n1cc(CN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.ejmech.2014.01.055
	127026132	137308	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	2.9	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cnn(C)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3760010	137308	0	None	6	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	432	8	1	6	2.9	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2cnn(C)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	127041260	136519	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	430	7	0	4	4.1	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
	CHEMBL3746806	136519	0	None	5	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	430	7	0	4	4.1	CN(C1CCN(CCOc2ccccc2C(C)(C)C)CC1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2015.11.041
	90654838	112177	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233668	112177	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304237	112177	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	448	9	0	4	4.2	CC1(C)C(=O)N(Cc2ccccc2)C(=O)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	155545625	172879	0	None	102	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	255	4	1	3	3.5	CCOc1ccc2[nH]cc(-c3cncn3CC)c2c1	10.1016/j.ejmech.2019.03.017
	CHEMBL4529615	172879	0	None	102	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	255	4	1	3	3.5	CCOc1ccc2[nH]cc(-c3cncn3CC)c2c1	10.1016/j.ejmech.2019.03.017
	56944864	157006	0	None	-27	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	8	2	3	5.0	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4080369	157006	0	None	-27	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	457	8	2	3	5.0	Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	135367816	164272	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164272	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	145947937	167151	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4207653	167151	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4302655	167151	0	None	-13	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	11478226	136404	0	None	3	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc(OC)c(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	CHEMBL374297	136404	0	None	3	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	465	10	1	5	4.6	COc1ccc(OC)c(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	57399494	70099	0	None	-1	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL1946124	70099	0	None	-1	8	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
	135367816	164272	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164272	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	11430856	77652	26	None	-134	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
	CHEMBL209821	77652	26	None	-134	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT7 receptor by radioligand binding assayBinding affinity to 5HT7 receptor by radioligand binding assay	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
	127035062	135915	0	None	-23	19	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	135915	0	None	-23	19	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT7A receptor stably expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	11261344	168731	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	476	9	1	6	4.7	COc1ccc2oc(N3CCN(CCCCCC(=O)NC4CCCc5ccccc54)CC3)nc2c1	10.1021/jm049702f
	CHEMBL441560	168731	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	476	9	1	6	4.7	COc1ccc2oc(N3CCN(CCCCCC(=O)NC4CCCc5ccccc54)CC3)nc2c1	10.1021/jm049702f
	135367858	163218	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4205846	163218	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	216239	23576	114	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	CHEMBL1200485	23576	114	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	CHEMBL1336	23576	114	None	-9	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	155560943	175983	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4574931	175983	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	CHEMBL4597364	175983	0	None	-2344	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	382	4	2	6	3.2	COc1ccc2c(c1)c(-c1[nH]c(N)nc1C)cn2S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2019.06.001
	10698929	98882	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	607	5	0	7	5.6	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(OS(=O)(=O)C(F)(F)F)cccc2OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm0108505
	CHEMBL282413	98882	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	607	5	0	7	5.6	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2c(OS(=O)(=O)C(F)(F)F)cccc2OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm0108505
	71449628	80943	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	404	7	1	3	4.4	O=C(NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159317	80943	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	404	7	1	3	4.4	O=C(NC1CCN(CCOc2cccc(-c3ccccc3)c2)C1)c1cccc(F)c1	10.1016/j.ejmech.2012.07.043
	122181251	121328	0	None	-27	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	448	7	1	5	3.0	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3589977	121328	0	None	-27	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	448	7	1	5	3.0	COc1ccccc1N1CCN(CCCCN2C(=O)NC3(CCc4ccccc43)C2=O)CC1	10.1016/j.bmc.2015.04.026
	156022244	176637	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4635538	176637	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	241	2	0	2	3.4	CN(C)[C@H]1CCc2c(cccc2-c2ccco2)C1	10.1016/j.bmc.2019.115262
	76280896	104520	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2ncccc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	CHEMBL3113601	104520	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 minsDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins	ChEMBL	462	10	1	6	3.7	O=C(CCCCCN1CCN(c2ncccc2-c2ccncc2)CC1)NCc1ccc(F)nc1	10.1016/j.bmc.2014.01.016
	25107583	192265	0	None	-2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	CHEMBL522194	192265	0	None	-2	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	155533648	171309	0	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	486	9	0	6	4.7	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4469539	171309	0	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	486	9	0	6	4.7	O=C1c2cccc3cccc(c23)C(=O)N1CCCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1	10.1016/j.bmcl.2019.06.029
	155564824	174947	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5HT7 by radio-ligand binding displacement assayInhibition of human 5HT7 by radio-ligand binding displacement assay	ChEMBL	412	4	3	6	3.9	C[C@H]1[C@@H]2C[C@]2(n2cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b00689
	CHEMBL4578381	174947	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5HT7 by radio-ligand binding displacement assayInhibition of human 5HT7 by radio-ligand binding displacement assay	ChEMBL	412	4	3	6	3.9	C[C@H]1[C@@H]2C[C@]2(n2cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O	10.1021/acs.jmedchem.6b00689
	145954503	161857	0	None	-7	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	370	5	1	4	4.1	O[C@H](CCN1CCc2onc(-c3ccc(F)c(F)c3)c2C1)c1ccccc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4166092	161857	0	None	-7	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	370	5	1	4	4.1	O[C@H](CCN1CCc2onc(-c3ccc(F)c(F)c3)c2C1)c1ccccc1	10.1016/j.ejmech.2018.04.010
	168288598	191167	0	None	-177	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	400	10	3	9	1.8	COc1ccccc1N1CCN(CCCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5197911	191167	0	None	-177	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	400	10	3	9	1.8	COc1ccccc1N1CCN(CCCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	44278114	99729	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	334	5	1	3	3.8	CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	CHEMBL28833	99729	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	In vitro binding affinity to human 5-hydroxytryptamine 7 receptorIn vitro binding affinity to human 5-hydroxytryptamine 7 receptor	ChEMBL	334	5	1	3	3.8	CCCc1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1	10.1016/s0960-894x(01)00241-4
	126720425	161553	0	None	-354	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	369	4	1	5	3.7	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
	CHEMBL4161308	161553	0	None	-354	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	369	4	1	5	3.7	CC(C)c1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
	135367858	163218	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4205846	163218	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	127027386	137125	0	None	5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	8	1	5	3.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccnc2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3758466	137125	0	None	5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	403	8	1	5	3.0	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccnc2)CC1	10.1016/j.ejmech.2015.11.040
	156013612	176644	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	452	9	0	7	5.9	c1ccc2oc(SCCCCCCN3CCN(c4nsc5ccccc45)CC3)nc2c1	10.1016/j.bmc.2020.115459
	CHEMBL4635603	176644	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	452	9	0	7	5.9	c1ccc2oc(SCCCCCCN3CCN(c4nsc5ccccc45)CC3)nc2c1	10.1016/j.bmc.2020.115459
	90654840	112124	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233669	112124	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3302757	112124	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	478	10	0	5	4.2	COc1ccccc1N1CCN(CCCCCN2C(=O)N(Cc3ccccc3)C(=O)C2(C)C)CC1	10.1016/j.ejmech.2014.01.065
	57399494	70099	0	None	-1	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
	CHEMBL1946124	70099	0	None	-1	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	386	4	0	3	4.4	O=C1c2ccc(F)cc2CC1CCN1CCCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2020.115943
	54758202	65663	0	None	9	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
	CHEMBL1836858	65663	0	None	9	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
	10895284	102622	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	430	7	1	3	5.0	CC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	CHEMBL307686	102622	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	430	7	1	3	5.0	CC(=O)C1(c2ccccc2)CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1	10.1021/jm0104264
	117209964	185542	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	185542	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	52952308	62236	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	6	1	5	4.6	N#Cc1ccc(N2CCC(NCCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	CHEMBL1782793	62236	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	389	6	1	5	4.6	N#Cc1ccc(N2CCC(NCCC(=O)c3csc4ccccc34)CC2)cc1	10.1021/jm2000773
	90654680	109599	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235752	109599	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	468	8	1	4	3.5	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2014.03.005
	46206022	124069	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	CHEMBL3640608	124069	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	46206022	124069	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	CHEMBL3640608	124069	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	267	3	0	2	3.8	COc1ccccc1-c1ccccc1C1CCN(C)C1	nan
	155538451	171811	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	485	10	0	5	5.2	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4476432	171811	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	485	10	0	5	5.2	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.bmcl.2019.06.029
	117209964	185542	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	185542	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	156019279	177389	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	338	3	0	4	3.5	COc1cc2c3c(c1OC)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4645997	177389	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	338	3	0	4	3.5	COc1cc2c3c(c1OC)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	134157289	153535	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	CHEMBL3984812	153535	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	422	6	0	4	5.3	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl	10.1016/j.ejmech.2016.07.029
	44455943	168425	5	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	1	2	3	3.0	CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL439240	168425	5	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	243	1	2	3	3.0	CCC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
	118724637	120089	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3360997	120089	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	CHEMBL3546115	120089	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cellsDisplacement of [3H]]-5-CT from human cloned 5-HT7R expressed in HEK293 cells	ChEMBL	464	6	0	8	2.3	Cn1c(=O)c2c(ncn2CCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n(C)c1=O	10.1016/j.bmc.2014.11.008
	44582705	186403	0	None	-158	14	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490632	186403	0	None	-158	14	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned 5HT7 receptor by competitive binding experimentInhibition of human cloned 5HT7 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	155563374	174664	0	None	-831	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	423	3	1	5	4.5	O=S(=O)(c1ccc2cccnc2c1)n1cc(C2=CCNCC2)c2cc(Cl)ccc21	10.1021/acsmedchemlett.6b00056
	CHEMBL4572158	174664	0	None	-831	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	423	3	1	5	4.5	O=S(=O)(c1ccc2cccnc2c1)n1cc(C2=CCNCC2)c2cc(Cl)ccc21	10.1021/acsmedchemlett.6b00056
	53376041	66024	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL1851658	66024	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
	CHEMBL3215835	66024	0	None	-11	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells by radioligand binding assay	ChEMBL	431	6	0	6	3.7	O=c1c2cnc3ccccc3c2ncn1CCCCN1CCN(c2ccccc2F)CC1	10.1016/j.ejmech.2011.04.060
	134133064	144190	0	None	4	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
	CHEMBL3908870	144190	0	None	4	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	314	5	0	3	3.0	CC1(C)CC(=O)N(CCCCN2Cc3ccccc3C2)C(=O)C1	10.1016/j.bmc.2016.09.019
	122483223	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764650	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765874	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	56850387	71119	0	None	-1	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
	CHEMBL1926731	71119	0	None	-1	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
	CHEMBL1962455	71119	0	None	-1	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	365	8	1	3	3.2	O=C1C2CCCN2C(=O)N1CCCCNCCc1ccc2ccccc2c1	10.1021/jm2007886
	127026071	137222	0	None	25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	4.5	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759298	137222	0	None	25	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	4.5	CC(C)(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2015.11.040
	145963860	163663	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	CHEMBL4211091	163663	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr by microbeta counting analysis	ChEMBL	434	8	1	4	4.2	CC(C)c1ccccc1OCC(C)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmc.2017.03.057
	155525703	170476	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	452	8	1	8	1.6	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4456962	170476	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	452	8	1	8	1.6	COc1ccc(/C=C2\NC(=O)N(CCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	10950559	202258	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1016/j.bmc.2019.06.028
	CHEMBL69388	202258	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from human 5HT7 receptor expressed in in COS7 cells incubated for 30 mins by liquid scintillation counting method	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1016/j.bmc.2019.06.028
	122483223	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764650	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765874	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	42626293	150581	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	349	6	0	3	3.2	O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL395933	150581	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	349	6	0	3	3.2	O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	11200511	200035	0	None	-74	8	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12	10.1021/jm049243i
	CHEMBL606547	200035	0	None	-74	8	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cellsInhibition of [3H]-LSD binding to 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	403	5	2	3	4.3	CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12	10.1021/jm049243i
	127036932	136811	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3752900	136811	0	None	-2	22	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
	10950559	202258	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1021/jm0104264
	CHEMBL69388	202258	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	457	6	1	3	5.2	O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccc2C(F)(F)F)CC1)CCC3	10.1021/jm0104264
	122483223	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764650	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765874	137568	0	None	5	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	162662367	181452	0	None	18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	531	10	0	5	7.7	COc1ccc(-c2ccccc2C2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	CHEMBL4781056	181452	0	None	18	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay	ChEMBL	531	10	0	5	7.7	COc1ccc(-c2ccccc2C2CCN(CCCCOc3ccc(-c4cn5ccccc5n4)cc3)CC2)cc1	10.1016/j.ejmech.2020.112395
	156015306	177030	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	CHEMBL4640899	177030	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	269	2	0	1	3.9	CN(C)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	156020091	177604	0	None	-8	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	CHEMBL4649327	177604	0	None	-8	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	325	6	0	1	5.5	CCCN(CCC)[C@@H]1CCc2c(cccc2-c2ccccc2F)C1	10.1016/j.bmc.2019.115262
	145977338	163154	0	None	-74	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
	CHEMBL4205064	163154	0	None	-74	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT7A receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
	156021059	177553	0	None	-147	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	8	3.5	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12	10.1016/j.bmc.2020.115459
	CHEMBL4648581	177553	0	None	-147	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	436	8	0	8	3.5	O=c1n(CCCCCCN2CCN(c3nsc4ccccc34)CC2)nc2ccccn12	10.1016/j.bmc.2020.115459
	11257767	66681	8	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	389	7	1	5	2.1	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
	CHEMBL187088	66681	8	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	389	7	1	5	2.1	COc1ccccc1N1CCN(CCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm049743b
	11325873	125261	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	360	7	1	4	2.4	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccccc1)C2	10.1021/jm049743b
	CHEMBL364795	125261	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells	ChEMBL	360	7	1	4	2.4	COc1ccc2c(c1)CCN(CCCNS(=O)(=O)c1ccccc1)C2	10.1021/jm049743b
	118626042	165007	0	None	-9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4242170	165007	0	None	-9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	489	6	1	5	4.1	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3[nH]ccc23)CC1	10.1016/j.ejmech.2018.01.002
	162666794	183140	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4784726	183140	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803549	183140	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	423	8	1	4	4.9	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	155556806	173948	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	381	7	1	4	4.3	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	CHEMBL4555702	173948	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	381	7	1	4	4.3	O=c1[nH]c(CCCCN2CCC(Cc3ccccc3)CC2)nc2ccsc12	10.1016/j.ejmech.2019.111690
	164628817	185685	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
	CHEMBL4874069	185685	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
	44391622	65646	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	333	3	0	3	4.4	COc1c(-c2ccc3c(c2)C[C@H](N(C)C)CO3)ccc2ccccc12	10.1016/j.bmcl.2004.11.013
	CHEMBL183676	65646	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand	ChEMBL	333	3	0	3	4.4	COc1c(-c2ccc3c(c2)C[C@H](N(C)C)CO3)ccc2ccccc12	10.1016/j.bmcl.2004.11.013
	46204424	124031	5	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
	CHEMBL3640571	124031	5	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
	46204424	124031	5	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
	CHEMBL3640571	124031	5	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	239	3	1	2	3.0	Cc1cccc(-c2cccc(OC3CNC3)c2)c1	nan
	156020902	177445	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	378	5	0	4	4.3	COc1cc2c3c(c1OCC1CC1)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4646861	177445	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	378	5	0	4	4.3	COc1cc2c3c(c1OCC1CC1)-c1cc(N(C)C)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	53320866	56714	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
	CHEMBL1644486	56714	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins	ChEMBL	322	3	1	2	4.5	Clc1ccc(Cn2cc(-c3ccccc3)c3c2CCNC3)cc1	10.1016/j.bmcl.2010.11.078
	10383646	18560	0	None	-398	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
	CHEMBL1277917	18560	0	None	-398	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
	46205043	124045	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
	CHEMBL3640584	124045	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
	46205043	124045	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
	CHEMBL3640584	124045	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	309	6	1	3	3.8	Cc1ccccc1-c1ccc(OCC2CC2)c(OC2CNC2)c1	nan
	127051843	140207	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818200	140207	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	127051843	140207	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818200	140207	0	None	-33	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	46204084	124020	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
	CHEMBL3640560	124020	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
	46204084	124020	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
	CHEMBL3640560	124020	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	269	4	1	3	3.0	COc1ccc(-c2ccc(C)cc2)cc1OC1CNC1	nan
	134135516	143629	0	None	7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3904094	143629	0	None	7	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3ncccc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	25107582	186991	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	CHEMBL494661	186991	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	10.1021/jm800615e
	122196373	123755	0	None	-91	6	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	471	7	0	6	6.4	Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
	CHEMBL3634813	123755	0	None	-91	6	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation countingDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamus homogenates after 120 mins by liquid scintillation counting	ChEMBL	471	7	0	6	6.4	Fc1ccc2c(C3CCN(CCCOc4ccc(-c5nc6ccccc6o5)cc4)CC3)noc2c1	10.1016/j.bmcl.2015.09.045
	122181342	121357	0	None	-25	3	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3590094	121357	0	None	-25	3	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	494	7	1	4	4.9	O=C1NC2(CCC(c3ccccc3)CC2)C(=O)N1CCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2015.04.026
	118731354	117674	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	10	0	4	4.9	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409037	117674	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	496	10	0	4	4.9	CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1	10.1016/j.ejmech.2014.12.041
	57392825	68040	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL1916744	68040	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	CHEMBL3233402	68040	0	None	-5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	496	9	0	4	4.8	CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O	10.1016/j.ejmech.2014.01.065
	71602739	89246	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376462	89246	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
	164628817	185685	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
	CHEMBL4874069	185685	0	None	-14	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	349	6	0	4	3.4	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc2c(c1)CCC2	10.1016/j.ejmech.2021.113243
	56649649	67500	0	None	-91	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910140	67500	0	None	-91	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	59511191	184931	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	184931	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	90656689	110484	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	7	1	5	3.1	COC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262419	110484	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	353	7	1	5	3.1	COC(=O)c1cccc(NCCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	46204085	124021	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
	CHEMBL3640561	124021	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
	46204085	124021	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
	CHEMBL3640561	124021	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	287	4	1	3	3.2	COc1ccc(-c2ccc(F)c(C)c2)cc1OC1CNC1	nan
	134148917	147879	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	285	4	0	4	3.2	COc1ccccc1-c1cc(CN(C)C)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	CHEMBL3937741	147879	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	285	4	0	4	3.2	COc1ccccc1-c1cc(CN(C)C)cc2c1OCO2	10.1016/j.ejmech.2016.07.029
	35391328	68054	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	316	5	1	3	2.0	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917332	68054	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	316	5	1	3	2.0	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	155535879	176085	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
	CHEMBL4472629	176085	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
	CHEMBL4598209	176085	0	None	-194	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1ccc2ccn(S(=O)(=O)c3ccccc3)c2c1	10.1016/j.ejmech.2019.06.001
	127052488	140255	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
	CHEMBL3818799	140255	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
	90654672	109591	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235744	109591	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.03.005
	42428409	68053	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	366	5	1	3	3.2	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917331	68053	7	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	366	5	1	3	3.2	O=S(=O)(NCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	71451455	80992	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	9	1	5	4.1	CSc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159461	80992	0	None	-4	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	454	9	1	5	4.1	CSc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1	10.1016/j.ejmech.2012.07.043
	90654672	109591	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3235744	109591	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	480	9	1	5	3.5	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1	10.1016/j.ejmech.2014.12.041
	90654856	112183	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233677	112183	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3304304	112183	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	584	9	0	4	6.8	CC1(C)C(=O)N(Cc2ccc(Cl)cc2Cl)C(=O)N1CCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.ejmech.2014.01.065
	59511191	184931	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	184931	3	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	164621627	184891	0	None	-10	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	CHEMBL4862180	184891	0	None	-10	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	369	5	0	4	3.7	O=C1c2ccc(Cl)cc2CC1CCCN1CCN(c2ccccn2)CC1	10.1016/j.ejmech.2021.113243
	42618266	190475	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	408	9	1	5	3.7	COc1ccccc1N1CCN(CCCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	CHEMBL518752	190475	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	408	9	1	5	3.7	COc1ccccc1N1CCN(CCCCCCn2c(=O)[nH]c3ccccc32)CC1	10.1016/j.bmcl.2009.02.008
	11266074	65919	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	283	3	1	3	3.2	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N)C2	10.1021/jm0498102
	CHEMBL184666	65919	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	283	3	1	3	3.2	COc1cccc(OC)c1-c1cccc2c1CC[C@H](N)C2	10.1021/jm0498102
	75201901	165861	14	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	165861	14	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44439389	91334	0	None	8	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	324	3	1	5	2.8	COc1ccc2[nH]c3c(c2c1)CCN=C3c1cc([N+](=O)[O-])cn1C	10.1016/j.bmcl.2007.01.093
	CHEMBL241099	91334	0	None	8	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	324	3	1	5	2.8	COc1ccc2[nH]c3c(c2c1)CCN=C3c1cc([N+](=O)[O-])cn1C	10.1016/j.bmcl.2007.01.093
	146680920	171298	0	None	-2570	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cncc2ccccc12	10.1021/acsmedchemlett.6b00056
	CHEMBL4469309	171298	0	None	-2570	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells by microbeta liquid scintillation counting	ChEMBL	419	4	1	6	3.8	COc1ccc2c(c1)c(C1=CCNCC1)cn2S(=O)(=O)c1cncc2ccccc12	10.1021/acsmedchemlett.6b00056
	168269719	189408	0	None	-2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	444	7	3	8	2.9	COc1ccccc1N1CCN(c2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5171456	189408	0	None	-2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	444	7	3	8	2.9	COc1ccccc1N1CCN(c2nc(N)nc(NCCc3c[nH]c4ccccc34)n2)CC1	10.1016/j.ejmech.2021.113931
	127029652	137787	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3771222	137787	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	57399089	68063	0	None	-21	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917341	68063	0	None	-21	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	454	9	1	6	3.1	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2cnc3ccccc3c2)CC1	10.1016/j.bmc.2011.09.044
	127029652	137787	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.bmcl.2018.02.003
	127029652	137787	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL3771222	137787	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.bmcl.2018.02.003
	CHEMBL3771222	137787	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)Displacement of [3H]-5-carboxamidotryptamine from 5-HT7 receptor (unknown origin)	ChEMBL	516	8	2	5	3.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	134154531	152184	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	CHEMBL3973160	152184	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting	ChEMBL	418	7	0	5	4.7	COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC	10.1016/j.ejmech.2016.07.029
	9843889	16115	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
	CHEMBL12259	16115	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00166-9
	49850874	56153	0	None	-251	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632210	56153	0	None	-251	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	11397149	56166	0	None	-251	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	465	6	2	4	5.6	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632223	56166	0	None	-251	7	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay	ChEMBL	465	6	2	4	5.6	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)Nc5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	75306277	108754	0	None	-39	23	Human	7.1	pKi	=	7.1	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	CHEMBL3217984	108754	0	None	-39	23	Human	7.1	pKi	=	7.1	Binding	Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	281	3441	22	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	5312148	3441	22	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	CHEMBL12264	3441	22	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	10.1021/jm030841r
	9843889	16115	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	CHEMBL12259	16115	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm030841r
	71602739	89246	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
	CHEMBL2376462	89246	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	ChEMBL	388	6	0	4	4.7	COc1cccc(-c2ccccc2CN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2013.02.038
	117209911	185737	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	185737	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	6540428	184271	1	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
	CHEMBL3989558	184271	1	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
	CHEMBL485253	184271	1	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1016/j.ejmech.2019.111705
	9804612	90090	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238730	90090	0	None	-19	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	44439167	90112	0	None	-7	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238732	90112	0	None	-7	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	135398745	2858	108	None	-95	66	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	47	2858	108	None	-95	66	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	CHEMBL715	2858	108	None	-95	66	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	DB00334	2858	108	None	-95	66	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	76518515	140326	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3818881	140326	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819714	140326	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	60167166	74930	0	None	-25	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037430	74930	0	None	-25	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.ejmech.2012.03.042
	44395796	66613	0	None	-5	2	Rat	6.1	pKi	=	6.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C\CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL186734	66613	0	None	-5	2	Rat	6.1	pKi	=	6.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	343	6	0	5	1.5	COc1ccccc1N1CCN(C/C=C\CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	164613297	184024	0	None	-19	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cc(Cl)ccc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	CHEMBL4849230	184024	0	None	-19	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cc(Cl)ccc3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	13702393	154474	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	CHEMBL401541	154474	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	CHEMBL556983	154474	2	None	-7	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	181	0	2	3	1.4	NC1=Nc2cccc(Cl)c2CN1	10.1016/j.bmcl.2007.10.080
	122483249	137553	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764970	137553	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765842	137553	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	127052488	140255	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
	CHEMBL3818799	140255	0	None	-23	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	477	8	0	4	6.3	Fc1ccc(C(c2ccc(F)cc2)N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2016.06.011
	168287126	190959	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	414	6	3	7	2.9	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5194826	190959	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	414	6	3	7	2.9	Nc1nc(NCCc2c[nH]c3ccccc23)nc(N2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	162671691	183169	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4792268	183169	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803838	183169	0	None	-6	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	481	10	1	6	5.0	COc1ccccc1N1CCN(CCCCCC(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	136118730	75876	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	CHEMBL2058407	75876	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	162647425	178987	0	None	-208	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysis	ChEMBL	584	13	0	7	5.3	C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2020.112765
	CHEMBL4741978	178987	0	None	-208	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysis	ChEMBL	584	13	0	7	5.3	C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1	10.1016/j.ejmech.2020.112765
	10154897	64917	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182797	64917	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	350	8	3	7	3.1	CC(Nc1nc(N)nc(NCCOc2ccccc2)n1)c1ccccc1	10.1016/j.bmcl.2004.06.008
	44393075	65381	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	7	3	6	3.4	CC(Nc1nc(N)nc(NCCc2ccccc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL183462	65381	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	352	7	3	6	3.4	CC(Nc1nc(N)nc(NCCc2ccccc2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	197033	197463	58	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2021.128275
	CHEMBL589390	197463	58	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantBinding affinity to 5-HT7R (unknown origin) assessed as inhibition constant	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.bmcl.2021.128275
	197033	197463	58	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.ejmech.2009.10.035
	CHEMBL589390	197463	58	None	3	8	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5HT7 receptor by radioligand displacement assayBinding affinity to 5HT7 receptor by radioligand displacement assay	ChEMBL	319	3	0	3	3.9	Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1	10.1016/j.ejmech.2009.10.035
	11199511	75067	0	None	4	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2009.06.038
	CHEMBL204171	75067	0	None	4	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2009.06.038
	56850385	71118	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
	CHEMBL1926730	71118	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
	CHEMBL1962454	71118	0	None	6	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	351	7	1	3	3.1	O=C1C2CCCN2C(=O)N1CCCCNCc1ccc2ccccc2c1	10.1021/jm2007886
	44408833	74088	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL202780	74088	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmc.2011.09.044
	168282454	190611	0	None	3	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	485	11	4	8	3.6	Nc1nc(NCCCCN2CCN(c3ccccc3)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5189648	190611	0	None	3	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	485	11	4	8	3.6	Nc1nc(NCCCCN2CCN(c3ccccc3)CC2)nc(NCCc2c[nH]c3ccccc23)n1	10.1016/j.ejmech.2021.113931
	168292411	191283	0	None	8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	8	2.8	Nc1nc(NCCc2c[nH]c3ccccc23)nc(NCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5199820	191283	0	None	8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	457	9	4	8	2.8	Nc1nc(NCCc2c[nH]c3ccccc23)nc(NCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	145984065	165187	0	None	1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4246630	165187	0	None	1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	134141166	146212	0	None	15	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	496	11	1	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3924375	146212	0	None	15	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	496	11	1	5	5.2	COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccc(C#N)cc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	145946956	167023	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4166804	167023	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4300883	167023	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	532	8	2	5	3.9	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	155551353	173380	0	None	51	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	323	1	1	2	3.2	Cn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
	CHEMBL4541526	173380	0	None	51	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting methodDisplacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method	ChEMBL	323	1	1	2	3.2	Cn1cncc1-c1c[nH]c2ccc(I)cc12	10.1016/j.ejmech.2019.03.017
	127041108	136059	0	None	12	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc2ncccc12	10.1039/C5MD00166H
	CHEMBL3739582	136059	0	None	12	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cccc2ncccc12	10.1039/C5MD00166H
	127037679	136139	0	None	18	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cc(F)ccc2F)CC1	10.1039/C5MD00166H
	CHEMBL3740235	136139	0	None	18	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	438	8	1	4	3.9	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cc(F)ccc2F)CC1	10.1039/C5MD00166H
	127040760	136355	0	None	22	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1039/C5MD00166H
	CHEMBL3742251	136355	0	None	22	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	436	8	1	4	4.3	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(Cl)c2)CC1	10.1039/C5MD00166H
	11391654	179933	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	179933	0	None	-1	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	44408833	74088	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL202780	74088	0	None	112	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	363	6	0	3	4.5	CC(C)(CCCN1CC[C@@H]2CCCC[C@H]2C1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2005.11.067
	11199511	75067	0	None	4	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL204171	75067	0	None	4	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	369	6	0	3	4.2	O=S(=O)(c1ccccc1)C1(CCCN2CCc3ccccc3C2)CCC1	10.1016/j.bmcl.2005.11.067
	90656693	112170	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262432	112170	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304130	112170	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor expressed in CHO cells after 30 mins by radioligand displacement assay	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	90656693	112170	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262432	112170	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3304130	112170	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	431	8	1	4	4.9	CN(C(=O)CCCCCN1CCN(c2cccc3ccccc23)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	5	139	66	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	5202	139	66	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	CHEMBL39	139	66	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	DB08839	139	66	None	-3	55	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030030n
	10949445	164442	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	402	6	2	3	4.9	O=C1Nc2ccc(O)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	CHEMBL422587	164442	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	402	6	2	3	4.9	O=C1Nc2ccc(O)c3c2C1(CCCCN1CC=C(c2ccccc2)CC1)CCC3	10.1021/jm0104264
	46203757	124014	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
	CHEMBL3640555	124014	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
	46203757	124014	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
	CHEMBL3640555	124014	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	283	4	1	3	3.3	COc1ccc(-c2c(C)cccc2C)cc1OC1CNC1	nan
	60196078	81379	2	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	CHEMBL2164328	81379	2	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	268	3	1	3	2.8	COc1ccccc1-c1cccc(N2CCNCC2)c1	10.1021/jm3003679
	16006606	157107	3	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	191	1	2	4	1.3	COc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	CHEMBL408152	157107	3	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	191	1	2	4	1.3	COc1cccc2c1N=C(N)NC2C	10.1016/j.bmcl.2007.10.080
	24854040	160686	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
	CHEMBL411919	160686	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	445	7	1	3	5.6	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccc(Cl)cc21	10.1021/jm070279v
	25107647	186891	0	None	11	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	10.1021/jm800615e
	CHEMBL494118	186891	0	None	11	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	10.1021/jm800615e
	44319435	204384	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	346	4	1	2	4.1	O=C1Nc2cccc3c2C1(CCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL85814	204384	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	346	4	1	2	4.1	O=C1Nc2cccc3c2C1(CCCN1CCc2ccccc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	164609529	183872	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4846823	183872	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	24964217	86772	0	None	63	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	255	5	0	2	3.5	COc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL232792	86772	0	None	63	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	255	5	0	2	3.5	COc1ccccc1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	132547279	141657	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	434	9	0	6	4.1	CCOc1ccccc1N1CCN(CCCCCn2c(C)nc3ccccc3c2=O)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884095	141657	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	434	9	0	6	4.1	CCOc1ccccc1N1CCN(CCCCCn2c(C)nc3ccccc3c2=O)CC1	10.1016/j.bmc.2016.12.039
	118713688	113882	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	439	10	0	6	4.8	COc1ccccc1N1CCN(CCCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL3331391	113882	0	None	-40	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	439	10	0	6	4.8	COc1ccccc1N1CCN(CCCCCCCn2c(=O)sc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL5093342	213778	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	213778	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	164609529	183872	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4846823	183872	0	None	-11	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	10404657	97606	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
	CHEMBL273241	97606	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
	24963860	86771	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
	CHEMBL232791	86771	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.ejmech.2019.111705
	10404657	97606	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
	CHEMBL273241	97606	0	None	26	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	334	5	0	3	3.1	O=C1c2ccccc2C(=O)N1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2016.05.053
	24963860	86771	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	CHEMBL232791	86771	0	None	562	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human 5HT7 in sf9 cellsDisplacement of [3H]LSD from human 5HT7 in sf9 cells	ChEMBL	285	6	0	3	3.5	COc1cccc(OC)c1-c1cccc(CCN(C)C)c1	10.1016/j.bmcl.2007.03.054
	25107580	186920	0	None	2	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	CHEMBL494312	186920	0	None	2	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	72550642	113566	0	None	2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL3326982	113566	0	None	2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	491	10	1	4	5.6	COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1	10.1016/j.bmc.2014.07.026
	CHEMBL5093342	213778	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	213778	0	None	4	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	76325353	105926	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121438	105926	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139528	105926	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	411	5	0	4	5.3	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3C)c3ccccc23)CC1	10.1016/j.ejmech.2014.01.055
	16093484	97597	6	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL273170	97597	6	None	-4	6	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	229	0	2	3	2.6	CC1NC(N)=Nc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2007.10.080
	10939416	202505	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	456	7	2	4	3.9	NC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	CHEMBL70889	202505	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	456	7	2	4	3.9	NC(=O)Cn1c2c(c3ccccc31)CCN(CCCCC13CCCc4cccc(c41)NC3=O)C2	10.1021/jm0104264
	11729823	102485	1	None	-16	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1	10.1021/jm0200411
	CHEMBL306478	102485	1	None	-16	5	Human	8.1	pKi	=	8.1	Binding	Tested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSDTested on cell membranes from transfected cells selectively expressing human 5-hydroxytryptamine 7 receptor incubated with 1 nM [3H]LSD	ChEMBL	437	5	0	2	4.6	O=C(c1ccc(F)cc1)C1CCN(CCc2cccc(I)c2)CC1	10.1021/jm0200411
	66801028	111598	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	8	1	6	4.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	CHEMBL3289997	111598	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	501	8	1	6	4.4	O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(OC(F)(F)F)cc1	10.1021/jm401895u
	6603866	96966	15	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
	CHEMBL26998	96966	15	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
	CHEMBL541268	96966	15	None	-39	9	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1	10.1021/jm9911433
	46204427	124033	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	CHEMBL3640573	124033	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	46204427	124033	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	CHEMBL3640573	124033	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	293	3	1	2	4.0	Clc1ccc(-c2ccccc2Cl)cc1OC1CNC1	nan
	44327952	206294	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
	CHEMBL97518	206294	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
	21091965	68055	9	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	380	6	1	3	3.6	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917333	68055	9	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	380	6	1	3	3.6	O=S(=O)(NCCCN1CCc2ccccc2C1)c1ccc2ccccc2c1	10.1016/j.bmc.2011.09.044
	60196075	81391	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2cccc(N3CCNCC3)c2)nc1	10.1021/jm3003679
	CHEMBL2164341	81391	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	239	2	1	3	2.2	c1ccc(-c2cccc(N3CCNCC3)c2)nc1	10.1021/jm3003679
	66801528	156289	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4071451	156289	0	None	-5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	449	6	2	3	4.5	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.7b00839
	66801052	158400	0	None	-18	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4095979	158400	0	None	-18	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	3084440	159256	6	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)-c1c(O)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmcl.2007.01.093
	CHEMBL410604	159256	6	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)-c1c(O)c(OC)cc3c1C(C2)N(C)CC3	10.1016/j.bmcl.2007.01.093
	76518515	140326	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3818881	140326	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	CHEMBL3819714	140326	0	None	-4	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	454	7	1	5	5.8	O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1	10.1016/j.bmc.2016.06.011
	44401041	70128	0	None	-18	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL194659	70128	0	None	-18	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	313	2	0	3	4.1	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
	46205698	124060	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
	CHEMBL3640599	124060	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
	46205698	124060	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
	CHEMBL3640599	124060	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.	ChEMBL	237	2	1	1	3.7	Cc1cccc(-c2ccccc2C2CCNC2)c1	nan
	155526014	170487	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.9	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	CHEMBL4457095	170487	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry	ChEMBL	422	7	0	5	2.9	CCOc1ccccc1N1CCN(CCC(=O)N2CCN(c3ccccc3)CC2)CC1	10.1016/j.bmcl.2016.06.080
	44439387	91271	0	None	38	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	276	2	1	2	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	CHEMBL240888	91271	0	None	38	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	276	2	1	2	3.6	COc1cccc(C2=NCCc3c2[nH]c2ccccc32)c1	10.1016/j.bmcl.2007.01.093
	11773414	146740	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	380	4	1	4	4.2	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
	CHEMBL392887	146740	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	380	4	1	4	4.2	COc1cc2c(cc1OC)CN(/C=N/c1ccc3c(c1)C(O)CCCC3)CC2	10.1016/j.bmcl.2007.01.093
	1984087	161735	10	None	-2	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	3	5.3	COc1cc(CNCCC2=CCCCC2)ccc1OCc1ccccc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4164250	161735	10	None	-2	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	351	9	1	3	5.3	COc1cc(CNCCC2=CCCCC2)ccc1OCc1ccccc1	10.1016/j.ejmech.2018.04.010
	135	2486	38	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	1796	2486	38	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	4184	2486	38	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	CHEMBL6437	2486	38	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	DB06148	2486	38	None	-83	58	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards rodent 5-hydroxytryptamine 7 receptorBinding affinity towards rodent 5-hydroxytryptamine 7 receptor	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm030030n
	24768526	92786	0	None	-41	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	CHEMBL244792	92786	0	None	-41	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	10.1021/jm070487n
	117209911	185737	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	185737	1	None	5	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation countingDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by liquid scintillation counting	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	9992778	16068	0	None	-2	3	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3ncc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	CHEMBL122453	16068	0	None	-2	3	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandIn vitro binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand	ChEMBL	260	0	0	2	3.5	CN1CCc2ccc3ncc4cccc5c4c3c2[C@H]1C5	10.1016/s0960-894x(00)00655-7
	90656673	110469	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	308	2	1	3	3.1	Oc1cccc2c1CC(N1CCN(c3ccccc3)CC1)CC2	10.1016/j.ejmech.2014.04.034
	CHEMBL3262398	110469	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	308	2	1	3	3.1	Oc1cccc2c1CC(N1CCN(c3ccccc3)CC1)CC2	10.1016/j.ejmech.2014.04.034
	130442480	174688	0	None	-100	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	174688	0	None	-100	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	18377415	204392	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2n[nH]cc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	CHEMBL85897	204392	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	350	5	2	3	3.2	O=C1Nc2cccc3c2C1(CCCCN1CCc2n[nH]cc2C1)CCC3	10.1016/s0960-894x(02)00485-7
	71453156	80743	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	6	1	3	5.3	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158036	80743	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	422	6	1	3	5.3	Cc1ccccc1C(=O)NC1CCN(CCSc2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2012.07.043
	24768521	92566	0	None	-19	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	CHEMBL244162	92566	0	None	-19	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm070487n
	11178340	84257	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	CHEMBL222604	84257	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	446	8	1	5	4.7	O=C(CCCCCN1CCN(c2nc3ccccc3o2)CC1)NC1CCCc2ccccc21	10.1021/jm049702f
	155520499	169906	0	None	-3	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	494	9	0	6	4.6	O=[N+]([O-])c1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4449148	169906	0	None	-3	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	494	9	0	6	4.6	O=[N+]([O-])c1ccccc1N1CCN(CCCCCCN2c3cccc4cccc(c34)S2(=O)=O)CC1	10.1016/j.bmcl.2019.06.029
	145986720	166679	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	436	7	2	5	2.1	CC1(C)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4292541	166679	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	436	7	2	5	2.1	CC1(C)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O	10.1039/C8MD00168E
	CHEMBL4777443	212276	0	None	-39	14	Human	6.1	pKi	=	6.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	nan
	58405078	110194	0	None	2	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
	CHEMBL3260335	110194	0	None	2	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
	1342	36	42	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
	3	36	42	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
	CHEMBL277120	36	42	None	-33	19	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm030030n
	44327952	206294	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
	CHEMBL97518	206294	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	367	5	3	3	2.6	CC[C@@](C)(CO)CNC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/jm030030n
	44424665	85275	0	None	5	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	CHEMBL228882	85275	0	None	5	3	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	411	7	0	8	1.7	CCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCCN1CCc2ccccc2C1	10.1016/j.bmc.2007.05.017
	1342	36	42	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
	3	36	42	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
	CHEMBL277120	36	42	None	-13	19	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsDisplacement of [3H]LSD from rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells	ChEMBL	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	10.1021/jm3003679
	122483212	137556	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763858	137556	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765845	137556	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	122483212	137556	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763858	137556	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765845	137556	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	376	6	0	3	6.0	CC1CC(C)CN(CCCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	155543653	172614	0	None	-70	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1cccc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	CHEMBL4522568	172614	0	None	-70	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	348	4	1	7	2.0	CC(Oc1cccc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2019.06.022
	127028799	137697	0	None	6	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770293	137697	0	None	6	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	444	6	2	5	1.9	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(F)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	435595	55000	14	None	10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	238	4	0	4	3.0	CN(C)CCSc1nc2ccccc2s1	10.1016/j.bmcl.2003.11.050
	CHEMBL161846	55000	14	None	10	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells	ChEMBL	238	4	0	4	3.0	CN(C)CCSc1nc2ccccc2s1	10.1016/j.bmcl.2003.11.050
	129211	3680	75	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	2562	3680	75	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	488	3680	75	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	CHEMBL836	3680	75	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	DB00706	3680	75	None	-151	16	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm9905918
	127038282	136545	0	None	67	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	7	1	6	2.5	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.ejmech.2015.11.040
	CHEMBL3747117	136545	0	None	67	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	420	7	1	6	2.5	Cn1cc(S(=O)(=O)NC2CCN(CCOc3ccccc3C(C)(C)C)CC2)cn1	10.1016/j.ejmech.2015.11.040
	155567307	175359	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	457	10	0	4	5.6	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/j.bmcl.2019.06.029
	CHEMBL4587772	175359	0	None	-7	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from recombinant human 5HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	457	10	0	4	5.6	CCOc1ccccc1N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1	10.1016/j.bmcl.2019.06.029
	156013695	176686	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4636210	176686	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	285	2	0	1	4.4	CN(C)[C@@H]1CCc2c(cccc2-c2ccc(Cl)cc2)C1	10.1016/j.bmc.2019.115262
	90656678	110477	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	6	0	3	3.6	Cc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262412	110477	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	323	6	0	3	3.6	Cc1cccc(N(C)CCCN2CCN(c3ccccc3)CC2)c1	10.1016/j.ejmech.2014.04.034
	44414722	79929	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	296	5	1	3	2.9	COc1ccccc1CC(c1ccccc1)N1CCNCC1	10.1016/j.bmcl.2010.04.052
	CHEMBL214335	79929	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	296	5	1	3	2.9	COc1ccccc1CC(c1ccccc1)N1CCNCC1	10.1016/j.bmcl.2010.04.052
	2477	732	54	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	36	732	54	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	437	732	54	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	CHEMBL49	732	54	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	DB00490	732	54	None	-128	29	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmc.2019.115262
	2928642	161727	9	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	7	1	2	6.1	Cc1ccc(C(CCNC(C)c2ccc(Cl)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
	CHEMBL4164143	161727	9	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	353	7	1	2	6.1	Cc1ccc(C(CCNC(C)c2ccc(Cl)cc2)c2ccco2)cc1	10.1016/j.ejmech.2018.04.010
	2962174	162409	10	None	-44	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	410	5	1	4	4.2	O=C1N(Cc2ccccc2)C(c2ccccc2)=NC1(Nc1ccccn1)C(F)(F)F	10.1016/j.ejmech.2018.04.010
	CHEMBL4174981	162409	10	None	-44	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis	ChEMBL	410	5	1	4	4.2	O=C1N(Cc2ccccc2)C(c2ccccc2)=NC1(Nc1ccccn1)C(F)(F)F	10.1016/j.ejmech.2018.04.010
	44276170	95857	0	None	-25	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	0	5	3.9	COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	CHEMBL26135	95857	0	None	-25	4	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor	ChEMBL	382	9	0	5	3.9	COc1cccc(C(=O)CCCCN2CCN(c3ccccc3OC)CC2)c1	10.1021/jm020994z
	71456770	80939	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159313	80939	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	430	9	1	4	4.6	CCOc1ccccc1C(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1	10.1016/j.ejmech.2012.07.043
	145946620	166984	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4174681	166984	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	CHEMBL4300388	166984	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	456	7	2	6	1.8	COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3cccc(F)c3)C2=O)CC1	10.1016/j.ejmech.2018.01.093
	155548275	173207	0	None	-79	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	426	5	2	5	4.1	CCC(=O)Nc1nc(C)c(-c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)[nH]1	10.1016/j.ejmech.2019.06.001
	CHEMBL4537701	173207	0	None	-79	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	426	5	2	5	4.1	CCC(=O)Nc1nc(C)c(-c2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)[nH]1	10.1016/j.ejmech.2019.06.001
	144950987	179380	0	None	-707	6	Human	4.1	pKi	=	4.1	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	292	3	0	2	3.4	CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
	CHEMBL4746800	179380	0	None	-707	6	Human	4.1	pKi	=	4.1	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	292	3	0	2	3.4	CN(C)CCN1C(=O)c2ccccc2/C=C\c2ccccc21	10.1016/j.bmcl.2020.127493
	37219401	137292	5	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	378	7	1	4	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759874	137292	5	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	378	7	1	4	2.6	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(F)cc1	10.1016/j.ejmech.2015.11.040
	164618100	184768	0	None	-128	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4860275	184768	0	None	-128	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)ccc1Cl)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	164612518	184802	0	None	-41	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cccc(Cl)c3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	CHEMBL4860719	184802	0	None	-41	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	6	1	7	2.5	CN1CCN(c2nc(N)nc(CCCOc3cccc(Cl)c3Cl)n2)CC1	10.1016/j.ejmech.2020.112529
	122483275	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764133	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765875	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT7 receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	145975289	163015	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4203295	163015	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	472	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cccc(Br)c2)CC1)c1cccc(Cl)c1	10.1021/acs.jmedchem.8b00828
	122483275	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764133	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765875	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	127050699	140328	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819082	140328	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819726	140328	0	None	1	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	21071390	1948	48	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
	8689	1948	48	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
	CHEMBL3286580	1948	48	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
	DB11957	1948	48	None	-10471	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	398	9	2	2	4.9	Fc1ccc2c(c1)[nH]cc2CCNCc1cccc(c1)OCC(C(F)F)(F)F	10.1016/j.ejmech.2019.111857
	42618255	180984	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
	CHEMBL476862	180984	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	428	6	0	6	3.6	COc1cccc(-n2c(=O)n(CCN3CCN(c4ccccc4)CC3)c3ccccc32)c1	10.1016/j.bmcl.2009.02.008
	71454898	80732	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	467	7	1	4	5.9	O=C(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158025	80732	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	467	7	1	4	5.9	O=C(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	162671167	183165	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4790826	183165	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803803	183165	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	397	9	1	5	2.9	COc1ccccc1CNC(=O)CCCN1CCN(c2ccccc2OC)CC1	10.1016/j.ejmech.2020.112437
	56850926	71130	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926759	71130	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962491	71130	0	None	-67	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	134142907	144754	0	None	39	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3913100	144754	0	None	39	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	469	10	1	6	3.5	N#Cc1ccc(CNC(=O)CCOCCN2CCN(c3cccnc3-c3ccccc3)CC2)cc1	10.1016/j.ejmech.2016.05.005
	4431	2679	18	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
	73	2679	18	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
	CHEMBL8618	2679	18	None	-20	12	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2021.113931
	118706290	120009	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310116	120009	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545468	120009	0	None	-128	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	4431	2679	18	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
	73	2679	18	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
	CHEMBL8618	2679	18	None	-251	12	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2004.09.029
	15629493	200352	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	233	4	0	2	2.9	CCN(CC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	CHEMBL608536	200352	1	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	233	4	0	2	2.9	CCN(CC)[C@@H]1CCc2cccc(OC)c2C1	10.1021/jm030826m
	122483275	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764133	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765875	137569	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	3037629	183979	13	None	-21	7	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4848517	183979	13	None	-21	7	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assayDisplacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	52952421	62238	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	479	6	1	6	5.5	O=[N+]([O-])c1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)c(C(F)(F)F)c1	10.1021/jm2000773
	CHEMBL1782795	62238	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	479	6	1	6	5.5	O=[N+]([O-])c1ccc(N2CCCN(CCC(O)c3csc4ccccc34)CC2)c(C(F)(F)F)c1	10.1021/jm2000773
	155530779	170994	0	None	-11	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1cccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)c1	10.1016/j.ejmech.2019.111857
	CHEMBL4464881	170994	0	None	-11	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	376	8	2	4	4.8	COc1cccc(-c2ccc(CNCCc3c[nH]c4ccc(OC)cc34)o2)c1	10.1016/j.ejmech.2019.111857
	71462068	80746	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	443	6	1	4	4.8	O=C(NC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	CHEMBL2158039	80746	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	443	6	1	4	4.8	O=C(NC1CCN(CCOc2cc(Cl)ccc2Cl)CC1)c1ccc2ccccc2n1	10.1016/j.ejmech.2012.07.043
	126720394	161752	0	None	-1230	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	355	4	1	5	3.1	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
	CHEMBL4164541	161752	0	None	-1230	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	355	4	1	5	3.1	CCc1nc2c(N3CCNCC3)ccnc2n1Cc1cccc(Cl)c1	10.1016/j.ejmech.2017.12.053
	10421583	98713	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm9911433
	CHEMBL281357	98713	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm9911433
	44460808	203826	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3cc(Br)ccc32)CC1	10.1016/s0960-894x(02)00438-9
	CHEMBL81041	203826	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	335	3	0	3	3.0	CN1CCCN(CCn2ccc3cc(Br)ccc32)CC1	10.1016/s0960-894x(02)00438-9
	21092408	68070	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	CHEMBL1917348	68070	0	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	395	7	1	4	3.4	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1cccc2cccnc12	10.1016/j.bmc.2011.09.044
	57395084	71192	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1949964	71192	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
	CHEMBL1963027	71192	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]5-CT form human cloned 5HT7 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cnc2ccc(Cl)cc2c1	10.1016/j.bmc.2011.12.039
	10421583	98713	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm0108505
	CHEMBL281357	98713	1	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm0108505
	118728528	117208	0	None	-27	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4cccc(Cl)c4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	CHEMBL3401491	117208	0	None	-27	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis	ChEMBL	444	7	0	6	4.7	Cc1sc2ncn(CCCCCN3CCN(c4cccc(Cl)c4)CC3)c(=O)c2c1C	10.1016/j.bmcl.2015.02.042
	135367404	163992	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4215197	163992	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	118709751	113029	0	None	-691	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	CHEMBL3321792	113029	0	None	-691	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	122483249	137553	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764970	137553	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765842	137553	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.3	CC1CCCN(CCCCC(=O)n2c3ccccc3c3ccccc32)C1	10.1016/j.ejmech.2016.01.043
	135367817	162991	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4202995	162991	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	32354149	163830	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4213238	163830	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	374	7	1	4	2.8	Cc1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	47556338	166249	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	397	5	2	4	2.0	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCc3ccccc3C2)C1=O	10.1039/C8MD00168E
	CHEMBL4284656	166249	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7B receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting method	ChEMBL	397	5	2	4	2.0	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCc3ccccc3C2)C1=O	10.1039/C8MD00168E
	9843889	16115	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysisDisplacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysis	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.7b01898
	CHEMBL12259	16115	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysisDisplacement of [3H]-5-CT from from 5-HT7 receptor in rat hypothalamus membranes by Cheng-Prusoff equation analysis	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.7b01898
	127028153	137622	0	None	33	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	CHEMBL3769441	137622	0	None	33	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	456	7	2	6	1.8	COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1	10.1016/j.ejmech.2016.02.024
	156015769	176995	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	388	4	1	5	2.8	COc1cc2c3c(c1OC)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	CHEMBL4640588	176995	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	388	4	1	5	2.8	COc1cc2c3c(c1OC)-c1cc(NS(C)(=O)=O)ccc1CC3N(C)CC2	10.1016/j.bmc.2020.115578
	9843889	16115	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL12259	16115	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1016/j.ejmech.2014.08.023
	9843889	16115	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	CHEMBL12259	16115	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells	ChEMBL	399	7	0	3	4.8	O=C1c2cccc3cccc(c23)N1CCCCCN1CCN(c2ccccc2)CC1	10.1021/jm8014553
	145946714	166986	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4213352	166986	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300399	166986	0	None	-6	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	50878551	90300	60	None	1	18	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL2391541	90300	60	None	1	18	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT 7 (unknown origin) by competition binding assayBinding affinity to 5-HT 7 (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
	242	467	117	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	34	467	117	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	60795	467	117	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	CHEMBL1112	467	117	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	DB01238	467	117	None	-14	52	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting methodDisplacement of [3H]5-CT from rat cerebral cortex 5HT7 receptor measured after 30 mins by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2020.112709
	135367817	162991	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	CHEMBL4202995	162991	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1cccc(-c2n[nH]c3c2CCNCC3)c1	10.1021/acs.jmedchem.8b00642
	135367404	163992	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	CHEMBL4215197	163992	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccccc1-c1n[nH]c2c1CCNCC2	10.1021/acs.jmedchem.8b00642
	155512487	169091	2	None	-446	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	CHEMBL4437523	169091	2	None	-446	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	350	6	3	3	4.6	Oc1ccc(-c2ccc(CNCCc3c[nH]c4ccc(F)cc34)o2)cc1	10.1016/j.ejmech.2019.111857
	12088082	64780	0	None	17	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	7	3	7	2.8	C[C@H](Nc1nc(N)nc(NCCc2ccccn2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	CHEMBL182418	64780	0	None	17	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor	ChEMBL	353	7	3	7	2.8	C[C@H](Nc1nc(N)nc(NCCc2ccccn2)n1)c1ccc(F)cc1	10.1016/j.bmcl.2004.06.008
	44461048	167588	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	5	0	3	3.8	Brc1ccc2ccn(CCN3CCCN(CC4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	CHEMBL433134	167588	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD	ChEMBL	375	5	0	3	3.8	Brc1ccc2ccn(CCN3CCCN(CC4CC4)CC3)c2c1	10.1016/s0960-894x(02)00438-9
	135398737	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	38	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	722	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	CHEMBL42	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	DB00363	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm990550b
	127025244	137217	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)c(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	CHEMBL3759262	137217	0	None	11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr	ChEMBL	464	8	1	4	4.4	CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)c(F)c2)C3)c1	10.1016/j.ejmech.2015.11.040
	127041244	136535	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	416	8	0	4	4.0	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
	CHEMBL3747052	136535	0	None	6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr	ChEMBL	416	8	0	4	4.0	CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2ccccc2)CC1	10.1016/j.bmc.2015.11.041
	145984299	165188	0	None	-63	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4246655	165188	0	None	-63	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	507	6	0	7	4.2	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2018.01.002
	71456782	81010	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	364	7	1	4	2.3	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159479	81010	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	364	7	1	4	2.3	O=S(=O)(NC1CCN(CCOc2ccccc2)C1)c1ccc(F)cc1	10.1016/j.ejmech.2012.07.043
	71453280	81014	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
	CHEMBL2159483	81014	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	458	8	1	4	4.1	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cc(F)ccc1F	10.1016/j.ejmech.2012.07.043
	118731363	117683	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	566	8	0	5	4.5	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409046	117683	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	566	8	0	5	4.5	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	118731364	117684	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	578	9	0	4	6.0	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409047	117684	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	578	9	0	4	6.0	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1	10.1016/j.ejmech.2014.12.041
	118731366	117686	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	594	10	0	5	5.2	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	CHEMBL3409049	117686	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr	ChEMBL	594	10	0	5	5.2	O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCOCC1	10.1016/j.ejmech.2014.12.041
	145947456	167078	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4174055	167078	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	CHEMBL4301717	167078	0	None	33	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	467	6	2	6	2.2	CC1(c2ccc(Cl)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O	10.1016/j.ejmech.2018.01.093
	156017281	177081	0	None	-8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	466	8	0	6	4.0	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	CHEMBL4641609	177081	0	None	-8	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	466	8	0	6	4.0	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.bmc.2020.115459
	122377930	136116	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1039/C5MD00166H
	CHEMBL3740054	136116	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	420	8	1	4	3.8	CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc(F)c2)CC1	10.1039/C5MD00166H
	127041107	136265	0	None	8	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cncc2ccccc12	10.1039/C5MD00166H
	CHEMBL3741445	136265	0	None	8	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assayDisplacement of [3H]-5-carboxyamidotryptamine from human serotonin 5-HT7B receptor expressed in HEK293 cells after 1 hr by microplate reader based assay	ChEMBL	487	8	1	5	4.7	O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)CC1)c1cncc2ccccc12	10.1039/C5MD00166H
	11460460	181770	0	None	-8	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4784845	181770	0	None	-8	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	66800947	157676	0	None	-8	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4088249	157676	0	None	-8	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	433	6	2	3	4.0	O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.7b00839
	11397799	84295	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	CHEMBL222864	84295	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry	ChEMBL	421	8	1	4	4.2	COc1ccccc1N1CCN(CCCCC(=O)NC2CCCc3ccccc32)CC1	10.1016/j.ejmech.2014.08.023
	11326570	76352	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	383	7	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	CHEMBL206563	76352	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	383	7	0	3	4.7	O=S(=O)(c1ccccc1)C1(CCCN2CCC(c3ccccc3)C2)CCC1	10.1016/j.bmcl.2005.11.067
	44326733	111126	0	None	512	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	2	2	3	3.3	c1ccc2c3c([nH]c2c1)C(Cc1ccc2c(c1)OCO2)NCC3	10.1016/j.bmcl.2007.01.093
	CHEMBL328476	111126	0	None	512	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	306	2	2	3	3.3	c1ccc2c3c([nH]c2c1)C(Cc1ccc2c(c1)OCO2)NCC3	10.1016/j.bmcl.2007.01.093
	66801605	111560	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	520	8	1	7	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3289960	111560	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	520	8	1	7	5.0	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	25107579	186849	0	None	-1	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	CHEMBL493909	186849	0	None	-1	3	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells	ChEMBL	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	10.1021/jm800615e
	24854266	95790	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
	CHEMBL261009	95790	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm200547z
	24854266	95790	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
	CHEMBL261009	95790	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	463	7	1	3	5.7	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)c(Cl)cc21	10.1021/jm070279v
	155567476	175315	0	None	251	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	450	7	1	6	4.4	O=c1[nH]c(SCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4586787	175315	0	None	251	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	450	7	1	6	4.4	O=c1[nH]c(SCCCN2CCN(Cc3ccccc3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	10324985	76413	7	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL199824	76413	7	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL2068762	76413	7	None	-6	17	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human 5HT7 receptorBinding affinity to human 5HT7 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	44266244	206322	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	378	5	0	3	3.9	Cc1ccc(OC2CCN(CCN3CCCc4ccccc4C3=O)CC2)cc1	10.1016/s0960-894x(03)00077-5
	CHEMBL9770	206322	0	None	6	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	378	5	0	3	3.9	Cc1ccc(OC2CCN(CCN3CCCc4ccccc4C3=O)CC2)cc1	10.1016/s0960-894x(03)00077-5
	CHEMBL5074880	212558	0	None	1	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysisDisplacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintillation counter analysis	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	44266164	205447	0	None	19	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	423	4	0	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL9250	205447	0	None	19	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.	ChEMBL	423	4	0	5	3.5	O=C1c2ccccc2CCCN1CCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	155515687	169392	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	452	6	1	5	4.9	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	CHEMBL4441943	169392	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter	ChEMBL	452	6	1	5	4.9	O=c1[nH]c(CCCCN2CCN(c3cccc(Cl)c3)CC2)nc2c1sc1ccccc12	10.1016/j.ejmech.2019.111690
	24854270	95397	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
	CHEMBL259009	95397	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm070279v
	134136134	143892	0	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	584	15	1	6	5.5	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
	CHEMBL3906408	143892	0	None	6	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis	ChEMBL	584	15	1	6	5.5	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccc(OCCCN2CCOCC2)cc1	10.1016/j.ejmech.2016.05.005
	156020950	177538	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4648289	177538	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	251	2	0	1	3.8	CN(C)[C@H]1CCc2c(cccc2-c2ccccc2)C1	10.1016/j.bmc.2019.115262
	11525867	95766	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm200547z
	CHEMBL260870	95766	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	479	7	1	3	6.2	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21	10.1021/jm200547z
	66801160	111547	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289947	111547	0	None	-1	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	468	7	1	6	3.6	O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	1621	2386	16	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	17	2386	16	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	5761	2386	16	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	CHEMBL263881	2386	16	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	DB04829	2386	16	None	-34	45	Rat	8.0	pKi	=	8.0	Binding	Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm030826m
	118753672	120093	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
	CHEMBL2413451	120093	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
	CHEMBL3546228	120093	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 (unknown origin)Binding affinity to 5-HT7 (unknown origin)	ChEMBL	394	6	0	3	4.9	CN1C(=O)C2(CCCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.bmc.2013.06.020
	11740526	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
	CHEMBL2311141	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
	CHEMBL85602	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/acs.jmedchem.2c00633
	11740526	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
	CHEMBL2311141	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
	CHEMBL85602	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/j.ejmech.2011.05.010
	11740526	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	CHEMBL2311141	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	CHEMBL85602	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Ability to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cellsAbility to displace the radioligand [3H]5-carboxyamidotryptamine ([3H]5-CT) from human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1016/s0960-894x(02)00485-7
	162647173	179041	0	None	-2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
	CHEMBL4742856	179041	0	None	-2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	438	7	1	6	3.3	Cn1ccc2c(S(=O)(=O)N[C@@H]3CCN(CCCc4noc5ccccc45)C3)cccc21	10.1016/j.ejmech.2020.112149
	11740526	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
	CHEMBL2311141	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
	CHEMBL85602	204357	0	None	79	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells	ChEMBL	380	5	0	3	4.5	CN1C(=O)C2(CCCCN3CCc4sccc4C3)CCCc3cccc1c32	10.1021/jm070279v
	10064053	95448	0	None	-5	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm030030n
	CHEMBL25924	95448	0	None	-5	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm030030n
	10064053	95448	0	None	-5	6	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm0108505
	CHEMBL25924	95448	0	None	-5	6	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm0108505
	2470	3583	46	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	3300	3583	46	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	5265	3583	46	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	99	3583	46	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	CHEMBL267930	3583	46	None	-389	60	Rat	8.0	pKi	=	8	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm030030n
	156016177	177070	0	None	18	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	CHEMBL4641502	177070	0	None	18	7	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
	66801173	111558	0	None	-1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	486	8	1	7	4.4	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	CHEMBL3289958	111558	0	None	-1	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	486	8	1	7	4.4	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
	66801226	111572	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	7	1	6	3.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	CHEMBL3289971	111572	0	None	9	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	452	7	1	6	3.1	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1	10.1021/jm401895u
	3994476	98506	7	None	-13	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL279841	98506	7	None	-13	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.ejmech.2021.113931
	57399091	68066	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
	CHEMBL1917344	68066	0	None	-2	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	440	8	1	6	2.7	COc1ccccc1N1CCN(CCCNS(=O)(=O)c2cccc3cccnc23)CC1	10.1016/j.bmc.2011.09.044
	11380477	179092	0	None	-17	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4743582	179092	0	None	-17	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	11288612	182019	0	None	-29	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4788327	182019	0	None	-29	4	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	44209480	69812	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2020.115943
	CHEMBL1940418	69812	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)Displacement of [3H]-LSD from 5HT7 receptor (unknown origin)	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2020.115943
	56944862	156215	0	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	CHEMBL4070715	156215	0	None	-19	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	477	8	2	3	5.3	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1	10.1021/acs.jmedchem.7b00839
	44209480	69812	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	CHEMBL1940418	69812	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.ejmech.2021.113243
	44209480	69812	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	CHEMBL1940418	69812	0	None	-81	11	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2011.12.019
	145947560	167136	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4212812	167136	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4302457	167136	0	None	-4	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	3994476	98506	7	None	-13	6	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL279841	98506	7	None	-13	6	Rat	7.1	pKi	=	7.1	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	345	7	0	5	1.7	COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	90656671	110488	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	7	1	4	4.7	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)c2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262423	110488	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	387	7	1	4	4.7	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)c2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	90644078	111584	0	None	-29	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	490	7	1	7	4.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	CHEMBL3289983	111584	0	None	-29	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	490	7	1	7	4.2	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cc2ccc(Cl)cc2s1	10.1021/jm401895u
	145963863	163664	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4211094	163664	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	438	7	1	4	3.3	O=S(=O)(NC1CCN(CCOc2ccccc2)CC1)c1ccc(Br)cc1	10.1021/acs.jmedchem.8b00828
	42618254	181424	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1-n1c(=O)n(CCN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2009.02.008
	CHEMBL478073	181424	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assayInhibition of human 5HT7 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	412	5	0	5	3.9	Cc1ccccc1-n1c(=O)n(CCN2CCN(c3ccccc3)CC2)c2ccccc21	10.1016/j.bmcl.2009.02.008
	127029375	137721	0	None	4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	CHEMBL3770522	137721	0	None	4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells	ChEMBL	460	6	2	5	2.4	CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)cc3)CC2)C1=O	10.1016/j.ejmech.2016.02.024
	134155461	153938	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3959209	153938	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3990475	153938	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	66800965	157637	0	None	-50	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4087852	157637	0	None	-50	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	461	8	2	3	4.8	O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1	10.1021/acs.jmedchem.7b00839
	134155461	153938	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3959209	153938	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	CHEMBL3990475	153938	0	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method	ChEMBL	291	4	1	2	3.6	c1ccc2c(c1)CCN(CCCc1nc3ccccc3[nH]1)C2	10.1016/j.bmc.2016.09.019
	156011357	176754	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	387	2	0	1	5.8	CN(C)[C@H]1CCc2c(cccc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
	CHEMBL4637353	176754	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	387	2	0	1	5.8	CN(C)[C@H]1CCc2c(cccc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1	10.1016/j.bmc.2019.115262
	44395797	66438	0	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	6	0	5	2.7	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	CHEMBL185936	66438	0	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptorIn vitro ability to displace the radioligand [3H]5-CT from binding to rat 5-hydroxytryptamine 7 receptor	ChEMBL	393	6	0	5	2.7	COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)CCC2=O)CC1	10.1016/j.bmcl.2004.09.029
	155566855	175658	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4586353	175658	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	CHEMBL4594758	175658	0	None	-645	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by liquid scintillation counter method	ChEMBL	352	3	2	5	3.2	Cc1nc(N)[nH]c1-c1cn(S(=O)(=O)c2ccccc2)c2ccccc12	10.1016/j.ejmech.2019.06.001
	52952307	62245	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	477	7	1	6	5.7	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1)c1csc2ccccc12	10.1021/jm2000773
	CHEMBL1782806	62245	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	477	7	1	6	5.7	O=C(CCNC1CCN(c2ccc([N+](=O)[O-])cc2C(F)(F)F)CC1)c1csc2ccccc12	10.1021/jm2000773
	52952200	62240	0	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	413	6	0	6	4.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
	CHEMBL1782798	62240	0	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	413	6	0	6	4.3	O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)c1csc2ccc(F)cc12	10.1021/jm2000773
	118709750	113028	0	None	-83	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321791	113028	0	None	-83	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
	76310813	105903	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121433	105903	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139442	105903	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	364	4	0	2	5.9	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)c3ccccc23)C1	10.1016/j.ejmech.2014.01.055
	11454449	84286	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	7	1	4	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	CHEMBL222807	84286	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	407	7	1	4	3.8	COc1ccccc1N1CCN(CCCC(=O)NC2CCCc3ccccc32)CC1	10.1021/jm049702f
	44401042	124296	0	None	-24	9	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	CHEMBL364270	124296	0	None	-24	9	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
	90656670	110489	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	401	8	1	4	4.6	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262424	110489	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	401	8	1	4	4.6	Oc1cccc(N(CCCN2CCN(c3ccccc3)CC2)Cc2ccccc2)c1	10.1016/j.ejmech.2014.04.034
	155554036	173619	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4548041	173619	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	334	4	1	7	1.4	CN1CCN(c2nc(N)nc(COc3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	162671630	183168	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4791207	183168	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4803834	183168	0	None	-32	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	467	9	1	6	4.6	COc1ccccc1N1CCN(CCCCC(=O)Nc2cccc(C(=O)OC(C)(C)C)c2)CC1	10.1016/j.ejmech.2020.112437
	66801053	182844	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	470	8	2	7	3.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1c[nH]c2ncccc12	10.1016/j.ejmech.2020.112437
	CHEMBL4798767	182844	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)	ChEMBL	470	8	2	7	3.1	O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1c[nH]c2ncccc12	10.1016/j.ejmech.2020.112437
	122181250	121327	0	None	-1	3	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	418	6	1	4	3.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	CHEMBL3589976	121327	0	None	-1	3	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysisDisplacement of [3H]-5-CT from 5-HT7 receptor in rat hypothalamic membrane by liquid scintillation analysis	ChEMBL	418	6	1	4	3.0	O=C1NC2(CCc3ccccc32)C(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2015.04.026
	71460453	80936	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	488	8	1	4	5.2	O=S(=O)(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159310	80936	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	488	8	1	4	5.2	O=S(=O)(NC1CCN(CCSc2ccccc2-c2ccccc2)CC1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	60195994	81386	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2cccc(N3CCNCC3)c2)cc1C	10.1021/jm3003679
	CHEMBL2164335	81386	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	266	2	1	2	3.4	Cc1ccc(-c2cccc(N3CCNCC3)c2)cc1C	10.1021/jm3003679
	145964390	163745	0	None	95	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cc(Br)ccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	CHEMBL4212254	163745	0	None	95	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	564	7	1	4	3.9	O=S(=O)(NC1CCN(CCOc2cc(Br)ccc2I)CC1)c1ccccc1	10.1021/acs.jmedchem.8b00828
	162659287	180697	0	None	-85	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
	CHEMBL4762226	180697	0	None	-85	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method	ChEMBL	459	7	1	6	4.2	O=S(=O)(N[C@H]1CCN(CCCc2noc3ccccc23)C1)c1cc2ccc(F)cc2s1	10.1016/j.ejmech.2020.112149
	53245590	91953	38	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	420	6	0	7	3.9	COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC	10.1021/ml400176n
	CHEMBL2431120	91953	38	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)	ChEMBL	420	6	0	7	3.9	COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC	10.1021/ml400176n
	145976946	163371	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	CHEMBL4207568	163371	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human serotonin 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assay	ChEMBL	416	7	1	4	3.8	CC(C)(C)c1cccc(OCCN2CCC(NS(=O)(=O)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.8b00828
	155538350	171804	0	None	-20	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	466	9	1	8	2.0	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	CHEMBL4476370	171804	0	None	-20	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter	ChEMBL	466	9	1	8	2.0	COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ncccn4)CC3)C2=O)cc1OC	10.1016/j.bmc.2019.07.046
	164611003	184752	0	None	-87	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4860006	184752	0	None	-87	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	382	4	1	7	2.7	CC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	56850796	71173	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926686	71173	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962913	71173	0	None	-7	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 minsDisplacement of [3H]-5-CT from 5HT7 receptor in Sprague-Dawley albinus rat hyphalamic membranes after 120 mins	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	76332585	105907	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3121441	105907	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
	CHEMBL3139446	105907	0	None	3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL	381	4	0	3	5.3	Cc1ccc(-n2cc(CN3CCN(c4ccccc4)CC3)c3ccccc32)cc1	10.1016/j.ejmech.2014.01.055
	11674602	68057	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	344	7	1	3	2.8	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	CHEMBL1917335	68057	2	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	344	7	1	3	2.8	O=S(=O)(NCCCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2011.09.044
	145947627	167119	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4163626	167119	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	CHEMBL4302240	167119	0	None	10	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method	ChEMBL	528	9	2	6	3.2	COc1ccc(C2(C)NC(=O)N(CC(O)CN3CCN(C(c4ccccc4)c4ccccc4)CC3)C2=O)cc1	10.1016/j.ejmech.2018.01.093
	90644076	111576	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	406	7	1	7	2.4	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	CHEMBL3289975	111576	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis	ChEMBL	406	7	1	7	2.4	O=S(=O)(NCCCN1CCN(c2noc3ccccc23)CC1)c1cccs1	10.1021/jm401895u
	134131147	141687	0	None	-5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
	CHEMBL3884584	141687	0	None	-5	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	436	8	0	5	4.6	O=c1cc(-c2ccccc2)ncn1CCCCCN1CCN(c2cccc(Cl)c2)CC1	10.1016/j.bmc.2016.12.039
	168282733	190455	0	None	-79	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	386	9	3	9	1.4	COc1ccccc1N1CCN(CCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	CHEMBL5187317	190455	0	None	-79	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	386	9	3	9	1.4	COc1ccccc1N1CCN(CCCCCNc2nc(N)nc(N)n2)CC1	10.1016/j.ejmech.2021.113931
	164628531	185872	0	None	-131	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	CHEMBL4876727	185872	0	None	-131	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method	ChEMBL	396	5	1	7	3.0	CCC(Oc1cc(Cl)cc(Cl)c1)c1nc(N)nc(N2CCN(C)CC2)n1	10.1016/j.ejmech.2020.112529
	122483229	137561	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764477	137561	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765850	137561	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	90654684	109603	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	502	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	CHEMBL3235756	109603	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting	ChEMBL	502	8	1	4	4.1	NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.ejmech.2014.03.005
	90654831	109325	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	CCOc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	CHEMBL3233401	109325	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting analysis	ChEMBL	512	9	0	5	4.4	CCOc1ccccc1N1CCN(CCCN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1	10.1016/j.ejmech.2014.01.065
	137635884	155347	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	427	7	2	3	4.1	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL4060649	155347	0	None	-5	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting	ChEMBL	427	7	2	3	4.1	Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1	10.1021/acs.jmedchem.7b00839
	CHEMBL5087742	213332	0	None	-22	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor transfected in CHO-K1 cells measured after 120 mins by scintillation counting method	ChEMBL		None	None	None		C[C@H]1C[C@H](NS(=O)(=O)c2csc3ccccc23)CN1CCCc1noc2cc(F)ccc12	10.1021/acs.jmedchem.1c00497
	90656702	112099	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3262433	112099	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	CHEMBL3302235	112099	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis	ChEMBL	435	9	1	4	5.2	CN(CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1cccc(O)c1	10.1016/j.ejmech.2014.04.034
	4713248	206160	3	None	2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	281	5	2	3	1.2	CNS(=O)(=O)c1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm030030n
	CHEMBL96729	206160	3	None	2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor	ChEMBL	281	5	2	3	1.2	CNS(=O)(=O)c1ccc2[nH]cc(CCN(C)C)c2c1	10.1021/jm030030n
	155531846	171069	0	None	-18	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	300	4	1	7	0.8	CN1CCN(c2nc(N)nc(COc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4465929	171069	0	None	-18	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	300	4	1	7	0.8	CN1CCN(c2nc(N)nc(COc3ccccc3)n2)CC1	10.1016/j.ejmech.2019.06.022
	162676589	183198	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4800511	183198	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	CHEMBL4804122	183198	0	None	-6	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method	ChEMBL	395	8	1	4	4.4	COc1ccccc1N1CCN(CCCC(=O)Nc2ccc(C(C)C)cc2)CC1	10.1016/j.ejmech.2020.112437
	164613772	187896	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4859722	187896	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL5028215	187896	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	122483229	137561	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764477	137561	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765850	137561	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL	348	5	0	3	5.5	O=C(CCCCN1CCCCCC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	45028192	62243	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	416	5	0	6	4.6	O=C(CCN1CCCN(c2cnc3ccccc3n2)CC1)c1csc2ccccc12	10.1021/jm2000773
	CHEMBL1782801	62243	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	416	5	0	6	4.6	O=C(CCN1CCCN(c2cnc3ccccc3n2)CC1)c1csc2ccccc12	10.1021/jm2000773
	7125890	117422	11	None	-6	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	408	4	1	4	5.8	Cc1ccc(Nc2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)cc1	10.1016/j.bmcl.2015.03.049
	CHEMBL3403341	117422	11	None	-6	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uMDisplacement of [3H]-5-CT from human cloned 5-HT7R expressed in HEK293 cells at 0.1 and 1 uM	ChEMBL	408	4	1	4	5.8	Cc1ccc(Nc2c(S(=O)(=O)c3ccccc3)cnc3ccc(Cl)cc23)cc1	10.1016/j.bmcl.2015.03.049
	164613772	187896	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL4859722	187896	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	CHEMBL5028215	187896	0	None	-2	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	380	6	1	5	2.9	O=C1CCc2cc(OCCCN3CCCN(c4ccccn4)CC3)ccc2N1	10.1016/j.ejmech.2021.113243
	155562652	174579	0	None	-15	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	552	9	1	7	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccc(OC)cc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
	CHEMBL4570209	174579	0	None	-15	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from recombinant human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	ChEMBL	552	9	1	7	5.3	COc1ccc(-c2c(=O)n(CCCCN3CCCC(c4c[nH]c5ccc(OC)cc45)C3)c(=O)n3ccccc23)cc1	10.1016/j.ejmech.2019.01.031
	60196076	81392	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	CHEMBL2164342	81392	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor	ChEMBL	298	4	1	4	2.8	COc1cccc(OC)c1-c1ccccc1N1CCNCC1	10.1021/jm3003679
	44408805	76370	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.8	O=S(=O)(CCCCN1CCC2CCCCC2C1)c1ccccc1	10.1016/j.bmcl.2005.11.067
	CHEMBL206667	76370	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from the cloned human 5-HT7 receptor expressed in CHO cells	ChEMBL	335	6	0	3	3.8	O=S(=O)(CCCCN1CCC2CCCCC2C1)c1ccccc1	10.1016/j.bmcl.2005.11.067
	54758203	65648	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
	CHEMBL1836783	65648	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry	ChEMBL	497	7	1	3	6.4	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c1cc(Cl)c(F)c2Cl	10.1021/jm200547z
	118626140	165354	0	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4250244	165354	0	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method	ChEMBL	520	6	1	4	5.7	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1	10.1016/j.ejmech.2018.01.002
	71456779	80984	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	3.7	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	CHEMBL2159454	80984	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr	ChEMBL	450	7	1	4	3.7	O=S(=O)(NC1CCN(CCOc2cc(Cl)ccc2Cl)C1)c1ccc(F)c(F)c1	10.1016/j.ejmech.2012.07.043
	156017999	177235	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	302	2	0	2	4.3	CN(C)C1CCc2c(cccc2-c2cncc3ccccc23)C1	10.1016/j.bmc.2019.115262
	CHEMBL4643725	177235	0	None	6	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method	ChEMBL	302	2	0	2	4.3	CN(C)C1CCc2c(cccc2-c2cncc3ccccc23)C1	10.1016/j.bmc.2019.115262
	164628882	185858	0	None	-48	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	477	6	0	6	3.4	COc1ccccc1N1CCN(Cc2ccc(CN3C(=O)c4ccccc4S3(=O)=O)cc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL4876545	185858	0	None	-48	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cellsDisplacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells	ChEMBL	477	6	0	6	3.4	COc1ccccc1N1CCN(Cc2ccc(CN3C(=O)c4ccccc4S3(=O)=O)cc2)CC1	10.1016/j.bmcl.2021.128028
	56649650	67501	0	None	-112	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910141	67501	0	None	-112	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT7 receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	13091359	113027	0	None	-138	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321790	113027	0	None	-138	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	44455973	97006	7	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	1	2	3	2.3	CCC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	CHEMBL270176	97006	7	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells	ChEMBL	209	1	2	3	2.3	CCC1NC(N)=Nc2cccc(Cl)c21	10.1016/j.bmcl.2007.10.080
	10960943	202548	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	428	7	1	3	5.4	CC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	CHEMBL71165	202548	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand	ChEMBL	428	7	1	3	5.4	CC(=O)c1ccc2c3c1CCCC3(CCCCN1CC=C(c3ccccc3)CC1)C(=O)N2	10.1021/jm0104264
	11488153	84702	0	None	2	3	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	CHEMBL224935	84702	0	None	2	3	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells	ChEMBL	430	8	1	4	4.4	N#Cc1cccc(N2CCN(CCCCCC(=O)NC3CCCc4ccccc43)CC2)c1	10.1021/jm049702f
	198967	91328	48	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	248	1	2	1	3.4	c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
	CHEMBL241083	91328	48	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells	ChEMBL	248	1	2	1	3.4	c1ccc(C2NCCc3c2[nH]c2ccccc32)cc1	10.1016/j.bmcl.2007.01.093
	44424655	142746	0	None	-19	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	CHEMBL389700	142746	0	None	-19	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membraneDisplacement of [3H]5CT from 5HT7 receptor in Wistar rat hyphalamic membrane	ChEMBL	440	8	0	9	1.4	CCCOc1nc2c(c(=O)n(C)c(=O)n2C)n1CCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.05.017
	60167309	74932	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.ejmech.2012.03.042
	CHEMBL2037432	74932	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5HT7 receptor by liquid scintillation counting	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.ejmech.2012.03.042
	60167309	74932	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	CHEMBL2037432	74932	0	None	-6	7	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor incubated for 1.5 hrs by microbeta scintillation counting method	ChEMBL	400	6	1	4	5.3	OC1(c2ccc(Cl)cc2)CCN(CCCCc2nc3ccccc3s2)CC1	10.1016/j.bmc.2016.06.011
	168295839	191637	0	None	-12	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	370	9	3	8	1.8	Nc1nc(N)nc(NCCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	CHEMBL5205324	191637	0	None	-12	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysisDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells incubated for 1 hr by microbeta plate reader analysis	ChEMBL	370	9	3	8	1.8	Nc1nc(N)nc(NCCCCCCN2CCN(c3ccccc3)CC2)n1	10.1016/j.ejmech.2021.113931
	156010295	176551	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	306	3	0	2	4.3	CCCN1CCc2cccc3c2C1Cc1ccc(N(C)C)cc1-3	10.1016/j.bmc.2020.115578
	CHEMBL4633889	176551	0	None	-3	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7A receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method	ChEMBL	306	3	0	2	4.3	CCCN1CCc2cccc3c2C1Cc1ccc(N(C)C)cc1-3	10.1016/j.bmc.2020.115578
	155515324	169377	0	None	-27	4	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	382	4	1	8	0.8	CN1CCN(c2nc(N)nc(CS(=O)(=O)c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	CHEMBL4441655	169377	0	None	-27	4	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 1 hr by radioligand binding assay	ChEMBL	382	4	1	8	0.8	CN1CCN(c2nc(N)nc(CS(=O)(=O)c3ccccc3Cl)n2)CC1	10.1016/j.ejmech.2019.06.022
	155519393	169840	0	None	-97	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	397	7	2	4	5.3	COc1ccc2[nH]cc(CCNCc3ccc(-c4cnc5ccccc5c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	CHEMBL4448285	169840	0	None	-97	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysisDisplacement of [3H]-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by microbeta plate reader analysis	ChEMBL	397	7	2	4	5.3	COc1ccc2[nH]cc(CCNCc3ccc(-c4cnc5ccccc5c4)o3)c2c1	10.1016/j.ejmech.2019.111857
	156019370	177373	0	None	-25	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	422	9	1	5	4.4	O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
	CHEMBL4645793	177373	0	None	-25	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [3H]-5-CT from human 5HT7b receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	422	9	1	5	4.4	O=C(NCCCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccccc1	10.1016/j.bmc.2020.115459
	134131159	141703	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	10	0	5	4.5	c1ccc(CN2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
	CHEMBL3884743	141703	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method	ChEMBL	416	10	0	5	4.5	c1ccc(CN2CCN(CCCCCOc3cc(-c4ccccc4)ncn3)CC2)cc1	10.1016/j.bmc.2016.12.039
	57397411	68073	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	CHEMBL1917351	68073	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting	ChEMBL	401	7	1	4	3.8	O=S(=O)(NCCCCN1CCC2CCCCC2C1)c1cnc2ccccc2c1	10.1016/j.bmc.2011.09.044
	1621	2386	16	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2386	16	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2386	16	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2386	16	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2386	16	None	-22	45	Human	8.1	pKd	=	8.1	Binding	GRAC: human 5-HT7 radioligandGRAC: human 5-HT7 radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	3233	3443	40	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	3247	3443	40	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	6604889	3443	40	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	CHEMBL282199	3443	40	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	DB13988	3443	40	None	2	12	Human	8.9	pKd	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	284	2859	63	None	457	2	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
	5283387	2859	63	None	457	2	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
	CHEMBL15927	2859	63	None	457	2	Human	8.6	pKd	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	15	1	1	5.5	CCCCCCCC/C=C\CCCCCCCC(=O)N	10571256
	2389	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	2389	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	5073	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	5073	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	96	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	96	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	CHEMBL85	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	CHEMBL85	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	DB00734	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	7908055
	DB00734	3267	114	None	-9	68	Rat	9.0	pKd	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	8997630
	1809	134	28	3H-MESULERGINE	-2	37	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-MESULERGINE	-2	37	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-MESULERGINE	-2	37	Rat	11.4	pKi	=	11.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	28	3H-MESULERGINE	2	37	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-MESULERGINE	2	37	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-MESULERGINE	2	37	Guinea pig	12.1	pKi	=	12.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	5	139	66	3H-MESULERGINE	3	55	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-MESULERGINE	3	55	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-MESULERGINE	3	55	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-MESULERGINE	3	55	Guinea pig	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	1809	134	28	3H-5HT	-7	37	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	28	3H-5HT	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	28	UNDEFINED	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-7	37	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	UNDEFINED	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-7	37	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	UNDEFINED	-2	37	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	23643664	2308	6	UNDEFINED	-1	6	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	8434	2308	6	UNDEFINED	-1	6	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	CHEMBL243954	2308	6	UNDEFINED	-1	6	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	5	139	66	3H-MESULERGINE	-5	55	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-MESULERGINE	-5	55	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-MESULERGINE	-5	55	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-MESULERGINE	-5	55	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	1809	134	28	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	28	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-2	37	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	28	3H-5CT	2	37	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5CT	2	37	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5CT	2	37	Guinea pig	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	5	139	66	3H-5CT	3	55	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5CT	3	55	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5CT	3	55	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5CT	3	55	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	116	3H-MESULERGINE	1	31	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-MESULERGINE	1	31	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-MESULERGINE	1	31	Guinea pig	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1809	134	28	125I-LSD	-2	37	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	125I-LSD	-2	37	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	125I-LSD	-2	37	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4106	2456	16	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-5HT	-2	34	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	1238	201475	21	3H-LSD	1	17	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	201475	21	3H-LSD	1	17	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	1809	134	28	3H-5HT	2	37	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	2	37	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	2	37	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1621	2386	16	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2386	16	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2386	16	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2386	16	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2386	16	3H-MESULERGINE	-1	45	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2389	3267	114	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3267	114	3H-5-CT	-9	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-5-CT	-9	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-5-CT	-9	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-5-CT	-9	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-MESULERGINE	-1	68	Guinea pig	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-5-CT	-9	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1809	134	28	125I-LSD	-2	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	125I-LSD	-2	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	125I-LSD	-2	37	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	28	UNDEFINED	-2	37	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	UNDEFINED	-2	37	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	UNDEFINED	-2	37	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	16362	3064	67	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	16362	3064	67	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3064	67	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3064	67	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3064	67	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3064	67	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3064	67	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3064	67	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3064	67	3H-LSD	-11	30	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3064	67	3H-LSD	-5	30	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	107	141	116	3H-5CT	1	31	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5CT	1	31	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5CT	1	31	Guinea pig	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1588	2284	24	125I-LSD	-9	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2284	24	125I-LSD	-9	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2284	24	125I-LSD	-9	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2284	24	125I-LSD	-9	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2284	24	125I-LSD	-9	44	Rat	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	107	141	116	3H-5HT	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	25107716	2309	35	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	8436	2309	35	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	CHEMBL522691	2309	35	UNDEFINED	3	7	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	None
	5	139	66	3H-5HT	-3	55	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	66	3H-5HT	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	66	UNDEFINED	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-3	55	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	UNDEFINED	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-3	55	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	UNDEFINED	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-3	55	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	UNDEFINED	-5	55	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	116	3H-MESULERGINE	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-MESULERGINE	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-MESULERGINE	-1	31	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	101	3750	18	3H-LSD	-1	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	55752	3750	18	3H-LSD	-1	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL35057	3750	18	3H-LSD	-1	14	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
	4106	2456	16	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	125I-LSD	-2	34	Rat	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	46780481	107032	18	3H-5HT	-4	54	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107032	18	3H-5HT	-4	54	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107032	18	3H-5HT	-4	54	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107032	18	3H-5HT	-4	54	Mouse	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	1809	134	28	3H-5CT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5CT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5CT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	25107518	186691	0	UNDEFINED	20	4	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	None
	CHEMBL492871	186691	0	UNDEFINED	20	4	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	441	10	1	3	5.4	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1	None
	1809	134	28	125I-LSD	-2	37	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	125I-LSD	-2	37	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	125I-LSD	-2	37	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1588	2284	24	3H-5HT	-9	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2284	24	3H-5HT	-9	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2284	24	3H-5HT	-9	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2284	24	3H-5HT	-9	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2284	24	3H-5HT	-9	44	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1809	134	28	3H-5HT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-7	37	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	23643870	92418	0	UNDEFINED	35	4	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243955	92418	0	UNDEFINED	35	4	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	448	9	1	4	4.6	CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	46780481	107032	18	3H-LSD	-16	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107032	18	3H-LSD	-16	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107032	18	3H-LSD	-16	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107032	18	3H-LSD	-16	54	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	1809	134	28	3H-5HT	-7	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-7	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-7	37	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	107	141	116	UNDEFINED	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	UNDEFINED	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	UNDEFINED	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	2389	3267	114	3H-LSD	-9	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	107	141	116	3H-5HT	-3	31	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	107	141	116	3H-5HT	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-3	31	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-3	31	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-1	31	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1809	134	28	3H-5CT	2	37	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5CT	2	37	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5CT	2	37	Guinea pig	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	25107520	187000	0	UNDEFINED	70	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	None
	CHEMBL494709	187000	0	UNDEFINED	70	3	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	442	10	1	4	4.7	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1	None
	1809	134	28	3H-5HT	-12	37	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-12	37	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-12	37	Mouse	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	5	139	66	3H-5HT	3	55	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	3	55	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	3	55	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	3	55	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	116	3H-5HT	1	31	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	1	31	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	1	31	Guinea pig	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	4106	2456	16	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-LSD	-2	34	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	2105	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	2105	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	2993	34	3H-5HT	-5	33	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	4106	2456	16	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	4106	2456	16	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	125I-LSD	-2	34	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	23643663	92398	0	UNDEFINED	13	4	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243744	92398	0	UNDEFINED	13	4	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	447	9	1	3	5.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	1809	134	28	3H-5HT	-2	37	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-2	37	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-2	37	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1809	134	28	3H-5HT	-12	37	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	28	3H-5HT	-12	37	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	28	3H-5HT	-12	37	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	115237	55281	113	3H-5HT	-5	55	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55281	113	3H-5HT	-5	55	Mouse	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	1238	201475	21	3H-LSD	1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	201475	21	3H-LSD	1	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	5	139	66	3H-5CT	3	55	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5CT	3	55	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5CT	3	55	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5CT	3	55	Guinea pig	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	2389	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5	139	66	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	66	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-5	55	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	116	3H-5CT	1	31	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5CT	1	31	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5CT	1	31	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	133	2450	48	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-MESULERGINE	-15	43	Guinea pig	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2389	3267	114	3H-5HT	-5	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-5HT	-5	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-5HT	-5	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-5HT	-5	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-5HT	-5	68	Mouse	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	107	141	116	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	107	141	116	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	125I-LSD	-1	31	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	103	4074	56	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4074	56	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4074	56	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4074	56	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4074	56	3H-LSD	-2	54	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5	139	66	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	66	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	125I-LSD	-5	55	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	242	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	206	2447	10	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-MESULERGINE	-6	25	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	133	2450	48	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-MESULERGINE	-16	43	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	4106	2456	16	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-5HT	-30	34	Guinea pig	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	2470	3583	46	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2470	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5HT	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	103	4074	56	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4074	56	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4074	56	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4074	56	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4074	56	3H-5HT	-8	54	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	242	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	467	117	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	[3H]-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	31101	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	31101	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	719	39	125I-LSD	-25	36	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	None	214271	0	3H-5CT	-67	8	Guinea pig	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	135	2486	38	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135	2486	38	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5HT	-21	58	Mouse	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-LSD	-50	58	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135398745	2858	108	3H-LSD	-34	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-34	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-34	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-34	66	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2470	3583	46	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5HT	-3019	60	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2543	3638	66	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	3H-MESULERGINE	-44	32	Guinea pig	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	100	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	681	1432	65	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	681	1432	65	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1432	65	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1432	65	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1432	65	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1432	65	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1432	65	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1432	65	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1432	65	3H-5HT	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1432	65	3H-LSD	-354	39	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	1209	1620	69	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1209	1620	69	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1620	69	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1620	69	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1620	69	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1620	69	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1620	69	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1620	69	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1620	69	3H-5HT	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1620	69	3H-LSD	-186	32	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1204	1893	114	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1204	1893	114	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1893	114	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1893	114	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1893	114	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1893	114	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1893	114	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1893	114	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1893	114	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1893	114	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1893	114	3H-5HT	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1893	114	3H-LSD	-616	25	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	12575	1949	28	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	12575	1949	28	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	54459	1949	28	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	54459	1949	28	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	CHEMBL10316	1949	28	3H-5HT	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	CHEMBL10316	1949	28	3H-LSD	-660	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
	1427	1974	50	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	1427	1974	50	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	1974	50	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	357	1974	50	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	1974	50	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	3696	1974	50	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	1974	50	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL11	1974	50	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	1974	50	3H-5HT	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	DB00458	1974	50	3H-LSD	-97	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
	1357	2440	133	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	3H-5HT	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	3H-LSD	-3311	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	484	2804	45	3H-5HT	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	484	2804	45	3H-LSD	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2804	45	3H-5HT	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2804	45	3H-LSD	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2804	45	3H-5HT	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2804	45	3H-LSD	-7	36	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	102484	2850	43	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	102484	2850	43	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	2149	2850	43	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	2149	2850	43	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	3396	2850	43	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	3396	2850	43	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	4581	2850	43	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	4581	2850	43	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	CHEMBL53929	2850	43	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	CHEMBL53929	2850	43	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	DB13251	2850	43	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	DB13251	2850	43	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.4	NCC(c1ccc(cc1)O)O	None
	2176	3065	66	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2176	3065	66	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3065	66	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3065	66	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3065	66	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3065	66	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3065	66	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3065	66	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3065	66	3H-5HT	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3065	66	3H-LSD	-6165	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	173	3199	88	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	173	3199	88	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3199	88	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3199	88	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3199	88	3H-5HT	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3199	88	3H-LSD	-11	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	189	3423	31	3H-5CT	-416	18	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3423	31	3H-5CT	-416	18	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3423	31	3H-5CT	-416	18	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	130	3431	43	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3378093	3431	43	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL281350	3431	43	35S-GTPGammaS	-275	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	108182	4055	18	3H-5HT	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	108182	4055	18	3H-LSD	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4055	18	3H-5HT	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4055	18	3H-LSD	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4055	18	3H-5HT	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4055	18	3H-LSD	-2	17	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	671690	26875	32	3H-5HT	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	671690	26875	32	3H-LSD	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	CHEMBL1365455	26875	32	3H-5HT	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	CHEMBL1365455	26875	32	3H-LSD	2	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
	4595	176131	102	3H-5HT	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	4595	176131	102	3H-LSD	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL46	176131	102	3H-5HT	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL46	176131	102	3H-LSD	-18	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	2771	193337	67	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	2771	193337	67	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL1200781	193337	67	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL1200781	193337	67	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL549	193337	67	3H-5HT	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL549	193337	67	3H-LSD	-12	27	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	54841	201428	51	3H-5HT	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	CHEMBL641	201428	51	3H-5HT	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
	2995	202690	49	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	2995	202690	49	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	2995	202690	49	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	202690	49	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	202690	49	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	202690	49	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	202690	49	3H-LSD	-141	23	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	202690	49	3H-5HT	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	202690	49	3H-LSD	-141	23	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	None	214183	0	125I-LSD	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	None	214183	0	3H-5HT	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	None	214183	0	3H-LSD	-616	15	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	86287410	214184	0	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	312	2	1	4	2.3	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
	86287410	214184	0	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	312	2	1	4	2.3	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
	None	214185	0	3H-5HT	-4	2	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	336	1	2	4	1.9	CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl	None
	None	214185	0	3H-LSD	-4	2	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	336	1	2	4	1.9	CN1C2CCC1CC(C2)NC(=O)N3C4=CC=CC=C4NC3=O.Cl	None
	None	214188	0	3H-5HT	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	2	1	4	1.9	CN1C2CCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
	None	214188	0	3H-LSD	-	1	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	2	1	4	1.9	CN1C2CCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C	None
	3035240	214190	0	3H-5HT	-11	5	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	359	3	2	4	2.6	COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl	None
	3035240	214190	0	3H-LSD	-11	5	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	359	3	2	4	2.6	COC1=CC(=C(C=C1C(=O)NC2CCN3CCCC2C3)Cl)N.Cl	None
	None	214227	0	3H-5HT	-43	6	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	367	2	1	6	2.4	CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl	None
	None	214227	0	3H-LSD	-43	6	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	367	2	1	6	2.4	CN1C2CCC1CC(C2)OC(=O)N3C4=C(C=CC(=C4)OC)NC3=O.Cl	None
	3337	214431	0	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	3337	214431	0	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214431	0	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214431	0	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214431	0	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214431	0	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214431	0	3H-5HT	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214431	0	3H-LSD	-151	41	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	1576	214565	0	3H-LSD	-1	41	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
	None	214693	0	Functional	-66	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	214693	0	UNDEFINED	-66	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	3075702	215584	0	3H-LSD	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
	1028	287	69	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	139148732	287	69	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	479	287	69	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	5816	287	69	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	CHEMBL679	287	69	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	DB00668	287	69	3H-5HT	-1862	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
	135398737	942	89	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5CT	-13	92	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	132	1244	9	3H-5HT	-20892	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
	155346	1244	9	3H-5HT	-20892	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
	CHEMBL378501	1244	9	3H-5HT	-20892	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	5	3	4	2.2	N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2	None
	681	1432	65	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	681	1432	65	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1432	65	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1432	65	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1432	65	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1432	65	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1432	65	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1432	65	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1432	65	3H-5HT	-1995	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1432	65	3H-5HT	-354	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	107780	1806	50	3H-LSD	-2691	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	14	1806	50	3H-LSD	-2691	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL15928	1806	50	3H-LSD	-2691	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	1204	1893	114	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1204	1893	114	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1893	114	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1247	1893	114	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1893	114	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1375	1893	114	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1893	114	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	774	1893	114	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1893	114	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	CHEMBL90	1893	114	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1893	114	3H-5HT	-1949	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	DB05381	1893	114	3H-5HT	-616	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
	1782	2472	81	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	241	2472	81	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	4168	2472	81	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	CHEMBL86	2472	81	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	DB01233	2472	81	3H-5HT	-676	23	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	135	2486	38	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5HT	-50	58	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	484	2804	45	3H-5HT	-100	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2804	45	3H-5HT	-100	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2804	45	3H-5HT	-100	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	2176	3065	66	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2176	3065	66	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3065	66	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3065	66	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3065	66	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3065	66	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3065	66	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3065	66	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3065	66	3H-5HT	-31622	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3065	66	3H-MESULERGINE	-6165	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	127	3066	45	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
	688095	3066	45	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL117405	3066	45	3H-5CT	-22908	15	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	O[C@H](COc1cccc2c1cc[nH]2)CNC(C)C	None
	2274	3112	53	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3112	53	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3112	53	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3112	53	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3112	53	3H-5CT	-4786	32	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	243	3141	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3052762	3141	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3502	3141	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	CHEMBL117287	3141	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	DB06480	3141	85	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	128563	3395	28	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	1666	3395	28	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	CHEMBL445332	3395	28	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	DB12327	3395	28	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	28	3427	37	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3292447	3427	37	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL20963	3427	37	3H-5CT	-6025	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	6917970	3622	54	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	8370	3622	54	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	CHEMBL487387	3622	54	3H-LSD	-2290	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	214	3787	52	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3787	52	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3787	52	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3787	52	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3787	52	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3787	52	3H-5CT	-4570	30	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	108182	4055	18	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4055	18	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4055	18	3H-5HT	-32	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	2662	11264	124	3H-LSD	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	CHEMBL118	11264	124	3H-LSD	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	10297	26890	29	3H-LSD	-38	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	CHEMBL136560	26890	29	3H-LSD	-38	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
	156391	46522	95	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL1200806	46522	95	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL154	46522	95	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	2244	93785	96	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	CHEMBL25	93785	96	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	3663	99492	79	3H-LSD	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	CHEMBL286494	99492	79	3H-LSD	-288	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
	446220	132985	13	3H-LSD	-1778	46	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	CHEMBL370805	132985	13	3H-LSD	-1778	46	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
	1615	167217	22	3H-LSD	-26	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167217	22	3H-LSD	-26	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	5280343	187681	119	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL1520590	187681	119	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL50	187681	119	3H-LSD	-147	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	4495	194850	87	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	CHEMBL56367	194850	87	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	54677470	198857	110	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL1256873	198857	110	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL599	198857	110	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	162265	200578	19	3H-LSD	-16	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	200578	19	3H-LSD	-16	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	200578	19	3H-LSD	-16	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	5281600	201327	85	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	CHEMBL63354	201327	85	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	5656	201368	82	3H-5HT	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	201368	82	3H-5HT	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	1973	201781	12	3H-LSD	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL1394464	201781	12	3H-LSD	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	CHEMBL66089	201781	12	3H-LSD	-3	37	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
	4158	203620	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL1722	203620	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL796	203620	21	3H-LSD	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	4054	203780	64	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL1699	203780	64	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL807	203780	64	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	57174031	214153	0	3H-5HT	-1778	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
	None	214207	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
	104911	214239	0	3H-LSD	-41686	38	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
	25137849	214415	0	3H-LSD	-1	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	214415	0	3H-LSD	-1	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	3337	214431	0	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214431	0	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214431	0	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214431	0	3H-LSD	-169	41	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	None	214451	0	3H-5-CABOXAMIDOTRYPTAMINE	-933	15	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	438	5	1	4	4.8	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45	None
	3821	214539	0	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(CCCCC1=O)C2=CC=CC=C2Cl	None
	None	214550	0	3H-LSD	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
	None	214551	0	3H-LSD	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
	None	214552	0	3H-LSD	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
	None	214553	0	3H-LSD	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
	None	214554	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
	None	214555	0	3H-LSD	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
	None	214556	0	3H-LSD	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
	None	214557	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
	None	214566	0	3H-LSD	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
	4978	214567	0	3H-LSD	-16	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
	None	214568	0	3H-LSD	-3	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
	None	214569	0	3H-LSD	-281	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
	None	214570	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
	135269	214629	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
	23681059	214630	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
	5018304	214631	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
	3672	214632	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)CC1=CC=C(C=C1)C(C)C(=O)O	None
	84003	214633	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
	123619	214634	0	3H-LSD	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
	119828	214635	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
	5090	214636	0	3H-LSD	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	119607	214637	0	3H-LSD	-97	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N	None
	None	214638	0	3H-LSD	-7	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
	None	214737	0	3H-LSD	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
	11957566	183	20	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	1219	183	20	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	3296	183	20	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	950	183	20	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	CHEMBL285755	183	20	3H-5HT	-549	9	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	None
	135398745	2858	108	3H-LSD	-34	66	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-34	66	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-34	66	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-34	66	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2858	108	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2858	108	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-95	66	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135	2486	38	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5CT	-138	58	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2470	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	265	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	89576	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	CHEMBL1288652	128	0	3H-5CT	-4	3	Guinea pig	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	179	396	107	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	396	107	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	396	107	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	396	107	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	396	107	3H-LSD	-9	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2470	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5HT	-1258	60	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	1353	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	135	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	3294	1967	106	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1967	106	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1967	106	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1967	106	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1967	106	3H-MESULERGINE	-41	45	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	135	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	125I-LSD	-50	58	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1353	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-LSD	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1872	85	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-5HT	-263	86	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	119570	3098	90	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3098	90	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3098	90	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3098	90	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3098	90	3H-LSD	-154	40	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	103	4074	56	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4074	56	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4074	56	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4074	56	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4074	56	3H-LSD	-6	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	11954259	214191	0	3H-LSD	-39	44	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	134	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2468	19	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5HT	-9	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	125I-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	206	2447	10	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-MESULERGINE	-15	25	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	134	2468	19	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-LSD	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	21830793	91389	5	3H-8-OH-DPAT	-85	46	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	CHEMBL2413154	91389	5	3H-8-OH-DPAT	-85	46	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	135398745	2858	108	3H-5HT	-61	66	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-5HT	-61	66	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-5HT	-61	66	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-5HT	-61	66	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	180	397	50	125I-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	397	50	125I-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	397	50	125I-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	397	50	125I-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	397	50	125I-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	277	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	277	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	3H-5HT	-70	46	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1346	83	108	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	280	83	108	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	9899402	83	108	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	CHEMBL9666	83	108	3H-5HT	-147	9	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	180	397	50	3H-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	397	50	3H-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	397	50	3H-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	397	50	3H-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	397	50	3H-LSD	-125	39	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	31101	719	39	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	719	39	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	719	39	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	719	39	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	719	39	3H-5HT	-181	36	Mouse	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	277	1269	55	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	3H-5CT	-301	46	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	3652	4022	72	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4022	72	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4022	72	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4022	72	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4022	72	3H-5CT	-6	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	1574	81	52	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	52	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	52	3H-5HT	-13	21	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	2801	161313	56	3H-5HT	-14	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	None
	CHEMBL1200710	161313	56	3H-5HT	-14	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	None
	CHEMBL415	161313	56	3H-5HT	-14	29	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21	None
	11954224	214164	0	3H- LSD	-18197	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	11954224	214164	0	3H-LSD	-18197	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	134	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	135398737	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	122	1404	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	156314	1404	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL1332062	1404	9	3H-5CT	-1	11	Guinea pig	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	134	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5HT	-18	68	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	135398737	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	125I-LSD	-7	92	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	24768524	92756	0	UNDEFINED	-4	4	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	None
	CHEMBL244577	92756	0	UNDEFINED	-4	4	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	423	8	1	3	4.7	O=C(CCCCCN1CCN(c2ccccc2F)CC1)NC1CCCc2ccccc21	None
	1613	2306	44	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2306	44	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2306	44	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2306	44	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2306	44	3H-5HT	-14	45	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	2337	3193	72	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-LSD	-15	63	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	1524	2141	89	3H-5HT	-512	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	3H-5HT	-512	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	3H-5HT	-512	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	3H-5HT	-512	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	3H-5HT	-512	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	3H-5HT	-512	52	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1220	186	46	3H-5CT	-51	45	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5CT	-51	45	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5CT	-51	45	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5CT	-51	45	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	179	396	107	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	396	107	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	396	107	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	396	107	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	396	107	3H-5CT	-9	51	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	11954224	214164	0	3H-5CT	-1174	60	Guinea pig	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	242	467	117	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-LSD	-14	52	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	135409468	1996	63	3H-LSD	-5	40	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	1996	63	3H-LSD	-5	40	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	1996	63	3H-LSD	-5	40	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	191	399	92	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	399	92	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	399	92	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	399	92	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	399	92	3H-5CT	-380	29	Guinea pig	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	214	3787	52	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3787	52	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3787	52	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3787	52	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3787	52	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3787	52	3H-5CT	-4570	30	Guinea pig	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	135398737	942	89	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5CT	-34	92	Guinea pig	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1150	3805	116	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3805	116	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3805	116	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3805	116	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	25107581	192020	0	UNDEFINED	-14	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	CHEMBL521687	192020	0	UNDEFINED	-14	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	505	12	1	7	3.7	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	1150	3805	116	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3805	116	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3805	116	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3805	116	3H-5HT	-6	25	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	5074	3268	75	3H-5HT	-38	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-5HT	-38	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-5HT	-38	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-5HT	-38	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	11954259	214191	0	3H-LSD	-51	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	5074	3268	75	3H-5HT	-38	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-5HT	-38	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-5HT	-38	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-5HT	-38	30	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	206	2447	10	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-5CT	-15	25	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	None	214156	0	3H-5CT	-17	11	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	11954259	214191	0	3H-LSD	-51	44	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
	2181	3067	0	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3067	0	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3067	0	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3067	0	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3067	0	3H-5HT	-125	35	Mouse	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	None	214151	0	3H-5HT	-2511	21	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	None	214151	0	UNDEFINED	-2511	21	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	2402	3306	58	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3306	58	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3306	58	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3306	58	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3306	58	3H-LSD	-6	25	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	135398745	2858	108	3H-LSD	-34	66	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-34	66	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-34	66	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-34	66	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2858	108	3H-LSD	-95	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-95	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-95	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-95	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	133	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	133	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	125I-LSD	-16	43	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1150	3805	116	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3805	116	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3805	116	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3805	116	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	1150	3805	116	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3805	116	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3805	116	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3805	116	3H-5HT	1	25	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	7153	97557	74	3H-LSD	-8	34	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97557	74	3H-LSD	-8	34	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	2337	3193	72	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-LSD	-28	63	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	134	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	11954224	214164	0	125I-LSD	-245	60	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	134	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	125I-LSD	-18	68	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	11954224	214164	0	125I-LSD	-245	60	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	2105	2993	34	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	2993	34	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	2993	34	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	2993	34	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	2993	34	3H-5CT	-11	33	Guinea pig	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	135398737	942	89	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-13	92	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1613	2306	44	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2306	44	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2306	44	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2306	44	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2306	44	125I-LSD	-14	45	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	None	214619	0	3H-LSD	-199	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
	2337	3193	72	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-LSD	-28	63	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	213	3780	50	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3780	50	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3780	50	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3780	50	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3780	50	3H-LSD	-9	44	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	11675876	186921	0	UNDEFINED	-54	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	CHEMBL494316	186921	0	UNDEFINED	-54	3	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	407	8	0	4	3.9	COc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	135398737	942	89	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	942	89	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	[3H]-5-CT	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	206	2447	10	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	1342	36	42	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	206	2447	10	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-5HT	-10	25	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	283	3069	47	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	4847	3069	47	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	CHEMBL18331	3069	47	3H-5CT	-28	12	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	1342	36	42	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	-13	19	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1588	2284	24	3H-5CT	-30	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2284	24	3H-5CT	-30	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2284	24	3H-5CT	-30	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2284	24	3H-5CT	-30	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2284	24	3H-5CT	-30	44	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2337	3193	72	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-LSD	-28	63	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	135398745	2858	108	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	191	399	92	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	399	92	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	399	92	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	399	92	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	399	92	3H-5CT	-380	29	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	1150	3805	116	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3805	116	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3805	116	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3805	116	3H-5CT	-1	25	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	135398737	942	89	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-7	92	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	10257	726	28	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	144	726	28	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	CHEMBL416526	726	28	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	DB01445	726	28	3H-5HT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	2726	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	5074	3268	75	3H-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	2470	3583	46	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	UNDEFINED	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5074	3268	75	3H-5CT	-66	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-5CT	-66	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-5CT	-66	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-5CT	-66	30	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	6852400	214150	0	3H-5CT	-1023	22	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	214150	0	3H-5CT	-1023	22	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	12016890	190172	4	3H-5HT	-3235	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
	CHEMBL5183389	190172	4	3H-5HT	-3235	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
	2274	3112	53	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3112	53	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3112	53	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3112	53	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3112	53	3H-LSD	-93	32	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	1621	2386	16	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2386	16	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2386	16	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2386	16	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2386	16	3H-5HT	-34	45	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1524	2141	89	3H-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	3H-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	3H-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	3H-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	3H-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	3H-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1220	186	46	3H-5HT	-75	45	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-75	45	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-75	45	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-75	45	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	133	2450	48	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	133	2450	48	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	125I-LSD	-16	43	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	5281082	214198	0	3H-LSD	30	3	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	411	7	1	6	3.5	CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)CCO	None
	1238	201475	21	3H-5CT	-13	17	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	201475	21	3H-5CT	-13	17	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	115237	55281	113	3H-LSD	-20	55	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55281	113	3H-LSD	-20	55	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	2389	3267	114	3H-LSD	-9	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	10090005	214200	0	3H-LSD	-3	11	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	361	1	0	3	4.4	CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42	None
	1588	2284	24	3H-5CT	-30	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2284	24	3H-5CT	-30	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2284	24	3H-5CT	-30	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2284	24	3H-5CT	-30	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2284	24	3H-5CT	-30	44	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2105	2993	34	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	2993	34	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	2993	34	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	2993	34	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	2993	34	3H-5CT	-11	33	Guinea pig	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	2470	3583	46	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5HT	-389	60	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	145	140	48	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	48	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	48	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	48	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	206	2447	10	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	145	140	48	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	48	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	48	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	48	125I-LSD	-4	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	25137849	214415	0	3H-LSD	-1	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	214415	0	3H-LSD	-1	41	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	1524	2141	89	125I-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	125I-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	125I-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	125I-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	125I-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	125I-LSD	-173	52	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	135398745	2858	108	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-5-CT	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135398745	2858	108	3H-LSD	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-95	66	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2726	904	64	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	2726	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	3H-LSD	-13	73	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	3H-LSD	-13	73	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	135398737	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	942	89	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-13	92	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5HT	-9	92	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	206	2447	10	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-5HT	-6	25	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	10257	726	28	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	144	726	28	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	CHEMBL416526	726	28	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	DB01445	726	28	3H-5CT	-13	19	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	3294	1967	106	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1967	106	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1967	106	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1967	106	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1967	106	3H-LSD	-21	45	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	5074	3268	75	125I-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	125I-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	125I-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	125I-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	5074	3268	75	125I-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	125I-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	125I-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	125I-LSD	-38	30	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	2470	3583	46	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5CT	-3019	60	Guinea pig	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	25107650	186692	0	UNDEFINED	-23	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	CHEMBL492872	186692	0	UNDEFINED	-23	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	407	10	1	3	4.8	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	62865	1243	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1243	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1243	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1243	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1243	0	3H-5HT	-7	15	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	163839	2899	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	268	2899	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	CHEMBL55171	2899	0	3H-LSD	-1	7	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
	25107649	186664	0	UNDEFINED	-1	3	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	CHEMBL492691	186664	0	UNDEFINED	-1	3	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	411	10	1	4	4.4	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	134	2468	19	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5CT	-37	68	Guinea pig	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	209	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	25107519	187076	0	UNDEFINED	-17	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	CHEMBL495120	187076	0	UNDEFINED	-17	3	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	10	1	4	3.7	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccccc2)CC1	None
	202	1475	0	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1475	0	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1475	0	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1475	0	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1475	0	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	209	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	209	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	2996	94	3H-LSD	-31	23	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	25137849	214415	0	3H-LSD	-1	41	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	71290	214415	0	3H-LSD	-1	41	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
	115	3720	78	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3720	78	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3720	78	3H-5HT	-8	27	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	1353	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1346	83	108	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	280	83	108	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	9899402	83	108	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	CHEMBL9666	83	108	125I-LSD	-147	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	None
	135398745	2858	108	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	5	139	66	3H-5HT	-5	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-5	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-5	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-5	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	206	2447	10	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-5HT	-16	25	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	209	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	2996	94	3H-LSD	-25	23	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	5074	3268	75	3H-MESULERGINE	-38	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-MESULERGINE	-38	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-MESULERGINE	-38	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-MESULERGINE	-38	30	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	2543	3638	66	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	3H-MESULERGINE	-44	32	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	24768520	92561	0	UNDEFINED	-1	5	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL244161	92561	0	UNDEFINED	-1	5	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	434	9	2	4	4.6	CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	135398745	2858	108	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-LSD	-95	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	2176	3065	66	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3065	66	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3065	66	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3065	66	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3065	66	3H-5HT	-6165	27	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2543	3638	66	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	3H-5HT	-44	32	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1220	186	46	3H-5HT	-199	45	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-199	45	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-199	45	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-199	45	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	2543	3638	66	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	3H-5HT	-44	32	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1220	186	46	3H-5CT	-199	45	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5CT	-199	45	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5CT	-199	45	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5CT	-199	45	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7153	97557	74	UNDEFINED	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97557	74	UNDEFINED	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	7153	97557	74	3H-5HT	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97557	74	3H-5HT	-14	34	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	265	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	89576	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	CHEMBL1288652	128	0	3H-5CT	-4	3	Guinea pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	266	5	2	2	3.2	NCCc1c[nH]c2c1cc(OCc1ccccc1)cc2	None
	1353	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-LSD	-120	86	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1524	2141	89	3H-5HT	-173	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	3H-5HT	-173	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	3H-5HT	-173	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	3H-5HT	-173	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	3H-5HT	-173	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	3H-5HT	-173	52	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1816	2494	99	3H-5HT	-165	17	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	4205	2494	99	3H-5HT	-165	17	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	7241	2494	99	3H-5HT	-165	17	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	CHEMBL654	2494	99	3H-5HT	-165	17	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	DB00370	2494	99	3H-5HT	-165	17	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	1830	2542	39	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2542	39	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2542	39	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2542	39	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2542	39	3H-LSD	-46	28	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	2726	904	64	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	3H-LSD	-13	73	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	None	214564	0	3H-LSD	-3	41	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
	15897	2807	0	3H-LSD	-12	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2807	0	3H-LSD	-12	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2807	0	3H-LSD	-12	37	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	24768525	143377	0	UNDEFINED	-7	4	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	None
	CHEMBL390213	143377	0	UNDEFINED	-7	4	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	406	8	1	4	4.0	O=C(CCCCCN1CCN(c2ccccn2)CC1)NC1CCCc2ccccc21	None
	2435	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	2435	3520	78	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	2435	3520	78	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3520	78	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3520	78	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3520	78	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3520	78	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3520	78	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3520	78	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3520	78	3H-5HT	-54	49	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3520	78	3H-LSD	-54	49	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	16106	117630	28	3H-LSD	-3	12	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
	CHEMBL340801	117630	28	3H-LSD	-3	12	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	0	0	3	2.9	CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1	None
	2435	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3520	78	3H-LSD	-36	49	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	24768518	92393	0	UNDEFINED	-46	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243743	92393	0	UNDEFINED	-46	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	461	11	1	3	5.9	CCCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	102	4051	44	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4051	44	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4051	44	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4051	44	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4051	44	3H-5HT	-851	50	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	214	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1524	2141	89	3H-5CT	-1047	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	3H-5CT	-1047	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	3H-5CT	-1047	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	3H-5CT	-1047	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	3H-5CT	-1047	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	3H-5CT	-1047	52	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2337	3193	72	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-5HT	-32	63	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	214	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3787	52	3H-LSD	-52	30	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	25107717	186957	0	UNDEFINED	-6	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	CHEMBL494512	186957	0	UNDEFINED	-6	3	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	420	10	1	5	3.6	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	2389	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	4106	2456	16	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-5CT	-4	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	2389	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	4106	2456	16	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	4106	2456	16	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	4106	2456	16	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-5CT	-30	34	Guinea pig	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-5HT	-4	34	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	None	214516	0	3H-LSD	-42	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	426	6	0	6	3.4	C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54	None
	25107648	186630	0	UNDEFINED	25	3	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	None
	CHEMBL492480	186630	0	UNDEFINED	25	3	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	467	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1	None
	145	140	48	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	48	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	48	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	48	3H-LSD	-2	30	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	134	2468	19	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-LSD	-24	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2435	3520	78	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3520	78	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3520	78	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3520	78	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3520	78	3H-LSD	-36	49	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	None	214156	0	3H-5CT	-17	11	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	1577	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3634	104	3H-5HT	-151	26	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	1830	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	173	3199	88	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3199	88	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3199	88	3H-LSD	-34	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	1830	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2542	39	3H-LSD	-30	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	2337	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	2337	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	3H-LSD	-28	63	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	25107517	186663	0	UNDEFINED	-1	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	CHEMBL492690	186663	0	UNDEFINED	-1	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	421	8	0	4	4.0	COc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	37459	733	10	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	733	10	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	733	10	3H-5HT	-74	25	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	206	2447	10	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-5CT	-10	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	133	2450	48	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-5HT	-36	43	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	282	1386	0	3H-5HT	-3548	7	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	522609	1386	0	3H-5HT	-3548	7	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	135398745	2858	108	3H-5CT	-95	66	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-5CT	-95	66	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-5CT	-95	66	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-5CT	-95	66	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	None	214693	0	3H-5CT	-208	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	214693	0	UNDEFINED	-208	28	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	5074	3268	75	125I-LSD	-38	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	125I-LSD	-38	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	125I-LSD	-38	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	125I-LSD	-38	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1238	201475	21	3H-5CT	-13	17	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL64249	201475	21	3H-5CT	-13	17	Guinea pig	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	1150	3805	116	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3805	116	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3805	116	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3805	116	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	25107515	186767	0	UNDEFINED	-16	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	CHEMBL493305	186767	0	UNDEFINED	-16	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	437	8	0	4	4.7	CSc1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	1353	1872	85	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-LSD	-263	86	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	5074	3268	75	125I-LSD	-38	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	125I-LSD	-38	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	125I-LSD	-38	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	125I-LSD	-38	30	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1150	3805	116	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3805	116	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3805	116	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3805	116	125I-LSD	1	25	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	1342	36	42	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1342	36	42	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	125I-LSD	-13	19	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	277	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1353	1872	85	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-5CT	-3801	86	Guinea pig	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	24768522	142032	0	UNDEFINED	2	4	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL389110	142032	0	UNDEFINED	2	4	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	462	9	2	4	4.5	CC(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	277	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	3H-5HT	-43	46	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	1220	186	46	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	25107651	187117	0	UNDEFINED	-4	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	CHEMBL495321	187117	0	UNDEFINED	-4	3	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	10	1	5	3.8	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	1220	186	46	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	179	396	107	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	396	107	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	396	107	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	396	107	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	396	107	3H-LSD	-9	51	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	166535	214182	0	3H-5HT	-87	2	Mouse	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	413	6	1	4	3.4	C1CN(CCC12C(=O)NCN2C3=CC=C(C=C3)F)CCCC(=O)C4=CC=C(C=C4)F	None
	1220	186	46	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1220	186	46	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	125I-LSD	-75	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	2726	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	2726	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	3H-LSD	-13	73	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	7153	97557	74	125I-LSD	-14	34	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97557	74	125I-LSD	-14	34	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	135	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	54477	84216	34	3H-LSD	-501	23	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	CHEMBL22242	84216	34	3H-LSD	-501	23	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	135398745	2858	108	3H-5HT	-95	66	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	3H-5HT	-95	66	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	3H-5HT	-95	66	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	3H-5HT	-95	66	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5HT	-50	58	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2477	732	54	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	732	54	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	732	54	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	732	54	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	732	54	125I-LSD	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	1353	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1353	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-LSD	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	242	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	1353	1872	85	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-5HT	-74	86	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	2477	732	54	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	732	54	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	732	54	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	732	54	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	732	54	3H-5HT	-21	29	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	25107652	186819	0	UNDEFINED	-20	3	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	CHEMBL493709	186819	0	UNDEFINED	-20	3	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	396	10	1	5	3.1	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	242	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-LSD	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	135398737	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	191	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	135398737	942	89	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5HT	-9	92	Mouse	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5HT	-7	92	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1613	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	134	2468	19	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5HT	-37	68	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2468	19	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5HT	-18	68	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2389	3267	114	3H-5HT	-9	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-5HT	-9	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-5HT	-9	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-5HT	-9	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-5HT	-9	68	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	16351	102244	41	3H-LSD	-1	6	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL304902	102244	41	3H-LSD	-1	6	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
	279	1623	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	49381	1623	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	CHEMBL63756	1623	26	3H-LSD	1	18	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
	2865	4064	67	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	3H-LSD	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	2105	2993	34	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	2993	34	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	2993	34	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	2993	34	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	2993	34	125I-LSD	-5	33	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	5	139	66	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	2865	4064	67	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	3H-5HT	-10	54	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	135398737	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	191	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	399	92	3H-LSD	-19	29	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	1220	186	46	3H-5CT	-51	45	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5CT	-51	45	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5CT	-51	45	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5CT	-51	45	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1353	1872	85	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-5-CT	-263	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	2601	3709	30	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3709	30	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3709	30	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3709	30	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3709	30	3H-5CT	-20	21	Guinea pig	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	15897	2807	0	3H-LSD	-12	37	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2807	0	3H-LSD	-12	37	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2807	0	3H-LSD	-12	37	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	3337	214431	0	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214431	0	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214431	0	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214431	0	3H-LSD	-169	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	25108474	192587	0	UNDEFINED	-38	3	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	CHEMBL523381	192587	0	UNDEFINED	-38	3	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	423	8	0	4	4.6	CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	135398737	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-13	92	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	24768523	143136	0	UNDEFINED	-4	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL390015	143136	0	UNDEFINED	-4	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	498	10	2	5	3.9	CS(=O)(=O)Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	1613	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2306	44	3H-LSD	-14	45	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	242	467	117	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-5-CT	-15	52	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5074	3268	75	3H-5HT	-74	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-5HT	-74	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-5HT	-74	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-5HT	-74	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	5074	3268	75	3H-5HT	-74	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-5HT	-74	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-5HT	-74	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-5HT	-74	30	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	4106	2456	16	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-5CT	-30	34	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5074	3268	75	3H-5CT	-66	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-5CT	-66	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-5CT	-66	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-5CT	-66	30	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1220	186	46	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1220	186	46	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-199	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	135398737	942	89	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5CT	-34	92	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	277	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2470	3583	46	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5CT	-3019	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	135398737	942	89	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5HT	-13	92	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	277	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	125I-LSD	-43	46	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	31101	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	31101	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	719	39	3H-5HT	-25	36	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	133	2450	48	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-5CT	-15	43	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	11954224	214164	0	3H-5CT	-1174	60	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	18971832	2375	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	21	2375	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	CHEMBL3186179	2375	0	3H-5HT	-812	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	24768517	92382	0	UNDEFINED	2	4	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243742	92382	0	UNDEFINED	2	4	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	447	10	1	3	5.5	CCCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	5	139	66	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	125I-LSD	-5	55	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	116	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	2865	4064	67	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	3H-5-CT	-12	54	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	5	139	66	3H-5HT	-11	55	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-11	55	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-11	55	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-11	55	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	116	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-3	31	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	11976	905	54	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	905	54	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	905	54	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	905	54	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	2389	3267	114	3H-5CT	-9	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	2389	3267	114	3H-MESULERGINE	-9	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-5CT	-9	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-MESULERGINE	-9	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-5CT	-9	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-MESULERGINE	-9	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-5CT	-9	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-MESULERGINE	-9	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-5CT	-9	68	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-MESULERGINE	-9	68	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5074	3268	75	3H-MESULERGINE	-66	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3268	75	3H-MESULERGINE	-66	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3268	75	3H-MESULERGINE	-66	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3268	75	3H-MESULERGINE	-66	30	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	25107578	192444	0	UNDEFINED	4	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	CHEMBL522343	192444	0	UNDEFINED	4	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	408	10	1	4	4.2	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccncc2)CC1	None
	216239	23576	114	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	CHEMBL1200485	23576	114	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	CHEMBL1336	23576	114	None	-9	7	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	66265	93566	12	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL248702	93566	12	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	2726	904	64	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	None	-301	73	Mouse	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	122	1404	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	156314	1404	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL1332062	1404	9	3H-5CT	-1	11	Guinea pig	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4223	3917	88	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	3917	88	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	3917	88	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	3917	88	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	3917	88	None	-81	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	102	4051	44	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4051	44	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4051	44	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4051	44	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4051	44	None	-851	50	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	11976	905	54	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	905	54	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	905	54	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	905	54	3H-LSD	-5	24	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	11976	905	54	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	905	54	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	905	54	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	905	54	3H-LSD	-5	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	25107718	186945	0	UNDEFINED	18	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	None
	CHEMBL494458	186945	0	UNDEFINED	18	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	535	12	1	6	4.7	CS(=O)(=O)Oc1ccc(CNC(=O)CCCCCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1	None
	240	929	39	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	929	39	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	929	39	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	929	39	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	929	39	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	929	39	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	929	39	None	-19	25	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2402	3306	58	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3306	58	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3306	58	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3306	58	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3306	58	None	-6	25	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	103	4074	56	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4074	56	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4074	56	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4074	56	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4074	56	3H-LSD	-6	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	1220	186	46	3H-5HT	-51	45	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-51	45	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-51	45	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-51	45	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	11954224	214164	0	3H-5HT	-269	60	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	6450478	214228	0	3H-LSD	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	0	0	6	3.4	CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42	None
	1353	1872	85	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-5HT	-120	86	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3033769	3217	54	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	3299	3217	54	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	94	3217	54	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	CHEMBL8809	3217	54	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	DB12518	3217	54	3H-LSD	-1380	19	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
	1577	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3634	104	3H-LSD	-151	26	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	54477	84216	34	3H-LSD	-69	23	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	CHEMBL22242	84216	34	3H-LSD	-69	23	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
	53389	97982	15	3H-LSD	-1	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.9	C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1	None
	CHEMBL275707	97982	15	3H-LSD	-1	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	3.9	C[C@H]1CN(CCCn2c3ccccc3c3ccccc32)C[C@@H](C)N1	None
	33630	178369	94	3H-LSD	-891	28	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL47050	178369	94	3H-LSD	-891	28	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	None	214201	0	3H-LSD	-1	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	342	1	1	5	1.8	CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2O)C=C(C=C4)Cl	None
	None	214202	0	3H-LSD	-1	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	334	4	0	3	4.9	C[N+](C)(CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)[O-]	None
	277	1269	55	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	3H-5CT	-301	46	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2176	3065	66	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3065	66	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3065	66	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3065	66	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3065	66	3H-MESULERGINE	-1584	27	Guinea pig	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2726	904	64	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	3H-5HT	-301	73	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	1577	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	164512405	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2537	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5355	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	5501	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	643497	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	688272	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	958	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	960	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL196677	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL26	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	CHEMBL267044	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB00391	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	DB16021	3634	104	3H-LSD	-194	26	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
	2543	3638	66	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	2543	3638	66	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	3H-5HT	-93	32	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	3H-5HT	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1220	186	46	3H-5HT	-199	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1220	186	46	3H-5HT	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-199	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	3H-5HT	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-199	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	3H-5HT	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-199	45	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	3H-5HT	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1220	186	46	UNDEFINED	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	UNDEFINED	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	UNDEFINED	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	UNDEFINED	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	283	3069	47	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	4847	3069	47	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	CHEMBL18331	3069	47	3H-5CT	-28	12	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	None	214271	0	3H-5CT	-67	8	Guinea pig	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	1220	186	46	125I-LSD	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	186	46	125I-LSD	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	186	46	125I-LSD	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	186	46	125I-LSD	-75	45	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	1342	36	42	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	125I-LSD	-13	19	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	115	3720	78	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3720	78	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3720	78	125I-LSD	-8	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	24768519	92417	0	UNDEFINED	1	3	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243953	92417	0	UNDEFINED	1	3	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	461	8	1	3	5.9	CC(C)(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	25108475	186892	0	UNDEFINED	-2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	CHEMBL494119	186892	0	UNDEFINED	-2	3	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	419	8	0	3	5.0	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C2)CC1	None
	681	1432	65	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1432	65	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1432	65	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1432	65	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1432	65	125I-LSD	-354	39	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	484	2804	45	125I-LSD	-7	36	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	951	2804	45	125I-LSD	-7	36	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	CHEMBL432	2804	45	125I-LSD	-7	36	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
	2176	3065	66	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3065	66	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3065	66	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3065	66	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3065	66	125I-LSD	-6165	27	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	2543	3638	66	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	125I-LSD	-44	32	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	108182	4055	18	125I-LSD	-2	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4055	18	125I-LSD	-2	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4055	18	125I-LSD	-2	17	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	73333	5871	23	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL1079935	5871	23	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	73333	5871	23	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL1079935	5871	23	3H-LSD	-35	9	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	135	2486	38	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5HT	-83	58	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2543	3638	66	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	125I-LSD	-44	32	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	15387	214199	0	3H-LSD	-85	24	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F	None
	15387	214199	0	3H-LSD	-85	24	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F	None
	10624	69942	17	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	69942	17	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	69942	17	3H-LSD	-46	33	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	2543	3638	66	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	None	-93	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5	139	66	3H- LSD	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H- LSD	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H- LSD	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H- LSD	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	2865	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	25107516	186592	0	UNDEFINED	-4	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	CHEMBL492282	186592	0	UNDEFINED	-4	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	8	0	3	5.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2CCc3ccccc3C2)CC1	None
	133	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	133	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-5HT	-16	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	191	399	92	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	399	92	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	399	92	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	399	92	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	399	92	None	-41	29	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	1353	1872	85	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	None	-74	86	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	107	141	116	3H-5HT	-9	31	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	3H-5HT	-9	31	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	3H-5HT	-9	31	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	135398737	942	89	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-7	92	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1588	2284	24	3H-5HT	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1588	2284	24	UNDEFINED	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2284	24	3H-5HT	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2284	24	UNDEFINED	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2284	24	3H-5HT	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2284	24	UNDEFINED	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2284	24	3H-5HT	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2284	24	UNDEFINED	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2284	24	3H-5HT	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2284	24	UNDEFINED	-9	44	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	4106	2456	16	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2456	16	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2456	16	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2456	16	3H-5HT	-15	34	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5	139	66	3H-5CT	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5CT	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5CT	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5CT	-3	55	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	206	2447	10	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	180	397	50	None	-12	39	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	180	397	50	None	-99	39	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	397	50	None	-12	39	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	397	50	None	-99	39	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	397	50	None	-12	39	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	397	50	None	-99	39	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	397	50	None	-12	39	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	397	50	None	-99	39	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	397	50	None	-12	39	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	397	50	None	-99	39	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2477	732	54	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	2477	732	54	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	732	54	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	732	54	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	732	54	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	732	54	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	732	54	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	732	54	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	732	54	None	-7	29	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	732	54	None	-21	29	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	1524	2141	89	None	-39	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	None	-39	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	None	-39	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	None	-39	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	None	-39	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	None	-39	52	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	133	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1353	1872	85	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	None	-263	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	133	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-5HT	-10	43	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1524	2141	89	None	-512	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	None	-512	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	None	-512	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	None	-512	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	None	-512	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	None	-512	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	114948	216007	0	None	1	3	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@@H]3C[C@H]4[C@@H](CC5=CNC6=CC=CC4=C56)N(C)C3)(O[C@@]2(O)[C@@H]2CCCN2C1=O)C(C)C	None
	2337	3193	72	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3193	72	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3193	72	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3193	72	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3193	72	None	-28	63	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	214	3787	52	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3787	52	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3787	52	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3787	52	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3787	52	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3787	52	None	-52	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1830	2542	39	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	207	2542	39	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	23897	2542	39	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	CHEMBL460	2542	39	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	DB01618	2542	39	None	-30	28	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
	1353	1872	85	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	None	-120	86	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1816	2494	99	None	-165	17	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	4205	2494	99	None	-165	17	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	7241	2494	99	None	-165	17	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	CHEMBL654	2494	99	None	-165	17	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	DB00370	2494	99	None	-165	17	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorInhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptor	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
	2543	3638	66	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	None	-44	32	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1621	2386	16	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2386	16	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2386	16	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2386	16	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2386	16	3H-LSD	-34	45	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2389	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	6971132	214225	0	3H-LSD	-1	14	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	268	1	2	2	2.1	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O	None
	2865	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	2865	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	3H-LSD	-12	54	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	1524	2141	89	None	-173	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	None	-173	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	None	-173	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	None	-173	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	None	-173	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	None	-173	52	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	4806	3933	85	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	7351	3933	85	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	9966051	3933	85	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	CHEMBL2104993	3933	85	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	DB09068	3933	85	None	1	13	Rat	8.2	pKi	=	8.2	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	228	441	26	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	33	441	26	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	6005	441	26	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	CHEMBL53	441	26	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	DB00714	441	26	None	-6	24	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	10531	1387	18	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	121	1387	18	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	888	1387	18	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	CHEMBL1732	1387	18	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	DB00320	1387	18	None	-87	24	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	1588	2284	24	3H-LSD	-28	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2284	24	3H-LSD	-28	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2284	24	3H-LSD	-28	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2284	24	3H-LSD	-28	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2284	24	3H-LSD	-28	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2895	201889	35	None	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	CHEMBL669	201889	35	None	-1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	277	1269	55	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	None	-70	46	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	3652	4022	72	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4022	72	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4022	72	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4022	72	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4022	72	None	-6	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	133	2450	48	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-5CT	-15	43	Guinea pig	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2389	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	3H-LSD	-9	68	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	11154555	786	57	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5037	786	57	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	7671	786	57	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL2028019	786	57	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL3085826	786	57	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB06016	786	57	None	-117	12	Human	8.2	pKi	=	8.2	Binding	CHO cells, [3H]LSD (1.5nM)CHO cells, [3H]LSD (1.5nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	2470	3583	46	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	None	-1258	60	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	135398745	2858	108	None	-95	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	None	-95	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	None	-95	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	None	-95	66	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135409468	1996	63	3H-LSD	-21	40	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	1996	63	3H-LSD	-21	40	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	1996	63	3H-LSD	-21	40	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	135398737	942	89	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	942	89	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5HT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5HT	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135398737	942	89	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	UNDEFINED	-7	92	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	133	2450	48	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	3H-5HT	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2470	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5567	42541	24	3H-LSD	-69	8	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
	CHEMBL15023	42541	24	3H-LSD	-69	8	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
	133	2450	48	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	UNDEFINED	-16	43	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2470	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-5HT	-1096	60	Mouse	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	135398737	942	89	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-5CT	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	100	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	107780	1806	50	3H-5CT	-2691	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	14	1806	50	3H-5CT	-2691	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL15928	1806	50	3H-5CT	-2691	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	1524	2141	89	3H-5CT	-1047	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	3H-5CT	-1047	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	3H-5CT	-1047	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	3H-5CT	-1047	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	3H-5CT	-1047	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	3H-5CT	-1047	52	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1150	3805	116	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3805	116	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3805	116	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3805	116	3H-5CT	-1	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	None	214476	0	3H-LSD	-64565	30	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
	135398737	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	206	2447	10	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	3H-5CT	-15	25	Guinea pig	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	135398737	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-13	92	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	135	2486	38	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5CT	-138	58	Guinea pig	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135	2486	38	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5HT	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135	2486	38	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	UNDEFINED	-50	58	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2274	3112	53	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3112	53	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3112	53	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3112	53	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3112	53	3H-LSD	-3235	32	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	180	397	50	None	-125	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	397	50	None	-125	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	397	50	None	-125	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	397	50	None	-125	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	397	50	None	-125	39	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	135	2486	38	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	None	-21	58	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135398745	2858	108	None	-34	66	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2858	108	None	-34	66	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2858	108	None	-34	66	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2858	108	None	-34	66	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	114948	216007	0	None	-1	3	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	577	5	3	6	2.5	CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@@H]3C[C@H]4[C@@H](CC5=CNC6=CC=CC4=C56)N(C)C3)(O[C@@]2(O)[C@@H]2CCCN2C1=O)C(C)C	None
	135	2486	38	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	None	-83	58	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	206	2447	10	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	129211	3680	75	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	2562	3680	75	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	488	3680	75	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	CHEMBL836	3680	75	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	DB00706	3680	75	None	-151	16	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand	Drug Central	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	None
	24768516	92140	0	UNDEFINED	11	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL243523	92140	0	UNDEFINED	11	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	433	9	1	3	5.1	CCc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	206	2447	10	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	125I-LSD	-6	25	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	100	3733	52	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3733	52	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3733	52	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3733	52	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3733	52	None	-28	56	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	135	2486	38	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	None	-50	58	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2470	3583	46	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	None	-1096	60	Mouse	8.1	pKi	=	8.1	Binding	Binding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligandBinding affinity towards mouse 5-hydroxytryptamine 7 receptor was evaluated using [3H]5-HT as radioligand	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	62865	1243	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	746	1243	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	84	1243	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	CHEMBL2104153	1243	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	DB09000	1243	0	None	-7	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
	100	3733	52	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3733	52	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3733	52	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3733	52	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3733	52	None	-18	56	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	277	1269	55	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	None	-43	46	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	11954224	214164	0	None	-269	60	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	1613	2306	44	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2306	44	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2306	44	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2306	44	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2306	44	None	-14	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	191	399	92	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	399	92	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	399	92	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	399	92	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	399	92	None	-19	29	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	135398737	942	89	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	None	-9	92	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2726	904	64	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	None	-13	73	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	49831411	216017	0	None	-1	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	659	19	0	6	8.7	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12	None
	133	2450	48	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	None	-36	43	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	2435	3520	78	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3520	78	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3520	78	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3520	78	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3520	78	None	-36	49	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	2220	3073	78	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	27400	3073	78	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	93	3073	78	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	CHEMBL294951	3073	78	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	DB06153	3073	78	None	-3	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	209	2996	94	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	2996	94	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	2996	94	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	2996	94	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	2996	94	None	-25	23	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	209	2996	94	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2113	2996	94	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4748	2996	94	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL567	2996	94	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00850	2996	94	None	-31	23	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	3294	1967	106	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1967	106	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1967	106	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1967	106	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1967	106	None	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	2726	904	64	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	None	-13	73	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	242	467	117	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	None	-15	52	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	3294	1967	106	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1967	106	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1967	106	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1967	106	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1967	106	None	-21	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	4806	3933	85	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	7351	3933	85	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	9966051	3933	85	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	CHEMBL2104993	3933	85	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	DB09068	3933	85	None	-8	13	Human	8.1	pKi	=	8.1	Binding	antagonistantagonist	Drug Central	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	None
	135398737	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	None	-13	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	242	467	117	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	None	-14	52	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	134	2468	19	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	None	-24	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	49831411	216017	0	None	-1	15	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	659	19	0	6	8.7	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12	None
	3294	1967	106	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1967	106	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1967	106	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1967	106	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1967	106	3H-LSD	-41	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	212	3734	43	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	2639	3734	43	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	941651	3734	43	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	CHEMBL1201	3734	43	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	DB01623	3734	43	None	-7	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
	134	2468	19	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	None	-18	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2468	19	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	None	-9	68	Mouse	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1212	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1621	2386	16	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2386	16	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2386	16	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2386	16	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2386	16	3H-MESULERGINE	-34	45	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2601	3709	30	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3709	30	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3709	30	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3709	30	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3709	30	3H-5CT	-20	21	Guinea pig	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2726	904	64	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	3H-5HT	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	100	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3733	52	3H-LSD	-18	56	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2726	904	64	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	904	64	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	904	64	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	904	64	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	904	64	UNDEFINED	-13	73	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	162265	200578	19	3H-LSD	-16	45	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	200578	19	3H-LSD	-16	45	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	200578	19	3H-LSD	-16	45	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	None	214476	0	3H-LSD	-64565	30	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
	25107583	192265	0	UNDEFINED	-2	3	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	CHEMBL522194	192265	0	UNDEFINED	-2	3	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	489	12	1	7	3.0	COc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	1712	2446	0	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2446	0	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2446	0	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2446	0	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2446	0	3H-LSD	-18	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	1712	2446	0	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	4078	2446	0	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	7227	2446	0	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	CHEMBL1088	2446	0	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	DB00933	2446	0	3H-LSD	-18	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
	3337	214431	0	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214431	0	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214431	0	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214431	0	3H-LSD	-169	41	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	1524	2141	89	3H-5HT	-512	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2141	89	3H-5HT	-173	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	3H-5HT	-512	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	3H-5HT	-173	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	3H-5HT	-512	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	3H-5HT	-173	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	3H-5HT	-512	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	3H-5HT	-173	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	3H-5HT	-512	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	3H-5HT	-173	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	3H-5HT	-512	52	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	3H-5HT	-173	52	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	25107582	186991	0	UNDEFINED	-9	3	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	CHEMBL494661	186991	0	UNDEFINED	-9	3	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	501	12	1	6	4.1	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(OS(C)(=O)=O)cc2)CC1	None
	277	1269	55	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	3H-5HT	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	135398737	942	89	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	3H-LSD	-13	92	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	277	1269	55	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1269	55	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1269	55	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1269	55	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1269	55	UNDEFINED	-43	46	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	None	214183	0	125I-LSD	-616	15	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	None	214183	0	125I-LSD	-616	15	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
	1524	2141	89	3H-5CT	-512	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2141	89	3H-5CT	-512	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2141	89	3H-5CT	-512	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2141	89	3H-5CT	-512	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2141	89	3H-5CT	-512	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2141	89	3H-5CT	-512	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2470	3583	46	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	None	-389	60	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	31101	719	39	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	719	39	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	719	39	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	719	39	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	719	39	None	-25	36	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	10531	1387	18	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	121	1387	18	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	888	1387	18	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	CHEMBL1732	1387	18	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	DB00320	1387	18	None	-23	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	1212	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1624	45	3H-LSD	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1624	45	3H-LSD	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1624	45	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	1212	1624	45	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1624	45	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1624	45	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1624	45	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1624	45	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1624	45	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1624	45	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1624	45	None	-18	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1624	45	None	-15	66	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3389	215972	0	None	-1	26	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
	5	139	66	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	66	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	3H-5HT	-3	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	133	2450	48	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	None	-16	43	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	135398737	942	89	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	942	89	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	942	89	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	942	89	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	942	89	None	-7	92	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	133	2450	48	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2450	48	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2450	48	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2450	48	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2450	48	None	-10	43	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	11976	905	54	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	667467	905	54	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	CHEMBL908	905	54	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	DB01239	905	54	None	-5	24	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
	145	140	48	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	48	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	48	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	48	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	2865	4064	67	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	25107647	186891	0	UNDEFINED	11	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	None
	CHEMBL494118	186891	0	UNDEFINED	11	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	453	8	0	3	5.6	O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1Cc2ccccc2C1	None
	145	140	48	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	48	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	48	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	48	3H-5HT	-4	30	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	103	4074	56	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4074	56	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4074	56	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4074	56	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4074	56	None	-6	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	11978813	712	72	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	5014	712	72	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	7672	712	72	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	CHEMBL2105760	712	72	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	DB09128	712	72	None	-6	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	2389	3267	114	None	-9	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	None	-9	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	None	-9	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	None	-9	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	None	-9	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	115237	55281	113	None	-20	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55281	113	None	-20	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	25107580	186920	0	UNDEFINED	2	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	CHEMBL494312	186920	0	UNDEFINED	2	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	432	10	1	4	4.7	CC(C)c1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	439280	119501	104	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	6971044	119501	104	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	CHEMBL350221	119501	104	None	-1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	1621	2386	16	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2386	16	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2386	16	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2386	16	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2386	16	None	-34	45	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	103	4074	56	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4074	56	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4074	56	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4074	56	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4074	56	None	-2	54	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2389	3267	114	None	-9	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3267	114	None	-9	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3267	114	None	-9	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3267	114	None	-9	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3267	114	None	-9	68	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	214	3787	52	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	2740	3787	52	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	5566	3787	52	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	66064	3787	52	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL422	3787	52	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00831	3787	52	3H-LSD	-95	30	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	135	2486	38	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2486	38	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2486	38	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2486	38	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2486	38	3H-5HT	-83	58	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	24768526	92786	0	UNDEFINED	-41	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	None
	CHEMBL244792	92786	0	UNDEFINED	-41	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	422	8	1	4	3.2	O=C(CCCCCN1CCN(c2cccc[n+]2[O-])CC1)NC1CCCc2ccccc21	None
	4452	2711	18	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	983	2711	18	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	CHEMBL20734	2711	18	3H-LSD	-2754	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	24768521	92566	0	UNDEFINED	-19	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	CHEMBL244162	92566	0	UNDEFINED	-19	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	420	8	2	4	4.1	Nc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1	None
	1342	36	42	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	134	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1342	36	42	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	42	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	42	3H-5HT	-33	19	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	134	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5HT	-24	68	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2477	732	54	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	732	54	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	732	54	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	732	54	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	732	54	[3H]-5-carboxamidotryptamine	-128	29	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	1613	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	1613	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	141	1394	32	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6089	1394	32	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	CHEMBL12420	1394	32	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	DB01488	1394	32	3H-LSD	1	22	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6852400	214150	0	3H-5CT	-1023	22	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	214150	0	3H-5CT	-1023	22	Guinea pig	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	1613	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	205	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	3964	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	CHEMBL831	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	DB00408	2306	44	3H-LSD	-23	45	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
	37459	733	10	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	733	10	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	733	10	UNDEFINED	-194	25	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	2105	2993	34	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	2993	34	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	2993	34	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	2993	34	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	2993	34	None	-5	33	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	25107579	186849	0	UNDEFINED	-1	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	CHEMBL493909	186849	0	UNDEFINED	-1	3	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	436	10	1	5	4.3	CSc1ccccc1N1CCN(CCCCCC(=O)NCc2ccc(C#N)cc2)CC1	None
	None	214151	0	3H-5HT	-151	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	None	214151	0	3H-5HT	-151	21	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	16362	3064	67	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3064	67	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3064	67	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3064	67	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3064	67	None	-5	30	Rat	8.0	pKi	=	8.0	Binding	Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	1588	2284	24	None	-9	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2284	24	None	-9	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2284	24	None	-9	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2284	24	None	-9	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2284	24	None	-9	44	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	213046	2343	55	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	4168	2343	55	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	7461	2343	55	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	CHEMBL1237021	2343	55	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	DB08815	2343	55	None	2	9	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	None
	16362	3064	67	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	2172	3064	67	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	90	3064	67	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	CHEMBL1423	3064	67	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	DB01100	3064	67	None	-11	30	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
	206	2447	10	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	2865	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	206	2447	10	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2447	10	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2447	10	125I-LSD	-6	25	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	2865	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4064	67	3H-LSD	-12	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	46780481	107032	18	None	-16	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107032	18	None	-16	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107032	18	None	-16	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107032	18	None	-16	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	1621	2386	16	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2386	16	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2386	16	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2386	16	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2386	16	3H-5HT	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	103	4074	56	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4074	56	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4074	56	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4074	56	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4074	56	3H-LSD	-6	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	None	214156	0	3H-5HT	-7	11	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	1621	2386	16	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2386	16	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2386	16	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2386	16	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2386	16	UNDEFINED	-34	45	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	242	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	467	117	3H-LSD	-15	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	2470	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3583	46	3H-LSD	-389	60	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	6852400	214150	0	3H-5HT	-223	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	214150	0	3H-5HT	-223	22	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	180	397	50	3H-5HT	-125	39	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	397	50	3H-5HT	-125	39	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	397	50	3H-5HT	-125	39	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	397	50	3H-5HT	-125	39	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	397	50	3H-5HT	-125	39	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	134	2468	19	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2468	19	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2468	19	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2468	19	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2468	19	3H-5CT	-37	68	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1353	1872	85	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1872	85	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1872	85	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1872	85	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1872	85	3H-5CT	-3801	86	Guinea pig	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	10257	726	28	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	144	726	28	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	CHEMBL416526	726	28	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	DB01445	726	28	3H-5CT	-13	19	Guinea pig	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	None
	2543	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	2543	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3638	66	3H-5HT	-93	32	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	100	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3733	52	3H-LSD	-28	56	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	4806	3933	85	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	7351	3933	85	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	9966051	3933	85	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	CHEMBL2104993	3933	85	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	DB09068	3933	85	None	-8	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	21486038
	281	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
	5312148	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
	CHEMBL12264	3441	22	None	1	5	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	6	0	3	3.1	CC1CCN(CC1)CC[C@H](N(S(=O)(=O)c1cccc(c1)C)C)C	9720804
	242	467	117	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	34	467	117	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	60795	467	117	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	CHEMBL1112	467	117	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	DB01238	467	117	None	-14	52	Rat	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10327430
	11959	1501	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	405	5	1	7	3.0	Cn1c(=O)c(c(cn1)NCCN1CCC(CC1)c1noc2c1ccc(c2)F)Cl	22824189
	9909267	1501	0	None	-2	4	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	405	5	1	7	3.0	Cn1c(=O)c(c(cn1)NCCN1CCC(CC1)c1noc2c1ccc(c2)F)Cl	22824189
	11151899	2097	10	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
	8432	2097	10	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
	CHEMBL4205783	2097	10	None	1	4	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	3	1	3	3.9	Clc1ccc(cc1)c1nn(c2c1CCNCC2)Cc1ccccc1	22570363
	24825775	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
	3929	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
	CHEMBL4205349	1490	10	None	346	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	257	4	0	3	2.8	CN(CCc1cccc(c1)c1c(C)nn(c1C)C)C	19118950
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
	8431	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
	9843179	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	10052959
	CHEMBL69257	1451	6	None	22	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	6	1	2	5.2	O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2	12825922
	10028436	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
	3237	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
	CHEMBL95104	3463	3	None	-1	12	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	12392747
	3233	3443	40	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	3247	3443	40	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	6604889	3443	40	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	CHEMBL282199	3443	40	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	DB13988	3443	40	None	2	12	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10807680
	5	139	66	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
	5	139	66	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
	5202	139	66	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
	5202	139	66	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
	CHEMBL39	139	66	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
	CHEMBL39	139	66	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
	DB08839	139	66	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394362
	DB08839	139	66	None	-5	55	Rat	9.0	pKi	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8397408
	23642275	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
	8433	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
	CHEMBL2164327	479	28	None	60	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	2	0	3	3.1	CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C	23541835
	25107716	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
	8436	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
	CHEMBL522691	2309	35	None	3	7	Rat	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	10	1	4	5.2	N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	18800769
	16362	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	2172	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	90	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	CHEMBL1423	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	DB01100	3064	67	None	-5	30	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	7908055
	213046	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	4168	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	7461	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	CHEMBL1237021	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	DB08815	2343	55	None	2	9	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	20404009
	11224758	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
	8435	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
	CHEMBL225284	2311	3	None	-4	7	Human	9.7	pKi	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	9	1	4	5.3	CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2	17649988
	23643664	2308	6	None	1	6	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
	8434	2308	6	None	1	6	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
	CHEMBL243954	2308	6	None	1	6	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	481	9	1	3	6.2	O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1	17649988
	162265	200578	19	None	-16	45	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	4786	200578	19	None	-16	45	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	CHEMBL61006	200578	19	None	-16	45	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
	3337	214431	0	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	65801	214431	0	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	66264	214431	0	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	91452	214431	0	None	-169	41	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)CC1=CC(=CC=C1)C(F)(F)F	None
	202	1475	0	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1475	0	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1475	0	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1475	0	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1475	0	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	213	3780	50	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3780	50	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3780	50	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3780	50	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3780	50	None	-9	44	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	119570	3098	90	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3098	90	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3098	90	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3098	90	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3098	90	None	-154	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	179	396	107	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	396	107	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	396	107	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	396	107	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	396	107	None	-9	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2726	904	64	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	621	904	64	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	83	904	64	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	CHEMBL71	904	64	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	DB00477	904	64	None	-301	73	Mouse	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	8394987
	18971832	2375	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	21	2375	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	CHEMBL3186179	2375	0	None	-812	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	257	3424	9	None	-19952	4	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
	5311423	3424	9	None	-19952	4	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
	CHEMBL114112	3424	9	None	-19952	4	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	474	6	1	6	3.3	CCCCN1CCC(CC1)COC(=O)c1cc(I)c(c2c1OCCO2)N	11414657
	29	778	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	9805719	778	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	CHEMBL2027925	778	0	None	-5011	9	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	102	4051	44	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	3659	4051	44	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	8969	4051	44	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	CHEMBL15245	4051	44	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	DB01392	4051	44	None	-851	50	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8226867
	240	929	39	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	2769	929	39	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	44279790	929	39	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	660	929	39	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	CHEMBL1729	929	39	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	CHEMBL560739	929	39	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	DB00604	929	39	None	-19	25	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	8394987
	2543	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	2543	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	5358	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	5358	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	54	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	54	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	CHEMBL128	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	CHEMBL128	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	DB00669	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8226867
	DB00669	3638	66	None	-93	32	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	9298538
	1524	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	1524	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	1524	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	1524	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	197	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	197	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	197	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	197	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	3822	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	3822	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	3822	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	3822	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	88	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	88	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	88	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	88	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	CHEMBL51	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	CHEMBL51	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	CHEMBL51	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	CHEMBL51	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	DB12465	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	11414657
	DB12465	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8226867
	DB12465	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9298538
	DB12465	2141	89	None	-512	52	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9720804
	1353	1872	85	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	3559	1872	85	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	86	1872	85	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	CHEMBL54	1872	85	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	DB00502	1872	85	None	-74	86	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8394987
	115	3720	78	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
	4296	3720	78	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
	CHEMBL274866	3720	78	None	-12	27	Mouse	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394987
	2543	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	2543	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	5358	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	5358	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	54	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	54	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	CHEMBL128	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	CHEMBL128	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	DB00669	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	DB00669	3638	66	None	-44	32	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	8397408
	180	397	50	None	-99	39	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	200	397	50	None	-99	39	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	2160	397	50	None	-99	39	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	CHEMBL629	397	50	None	-99	39	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	DB00321	397	50	None	-99	39	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394987
	2477	732	54	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	2477	732	54	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	36	732	54	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	36	732	54	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	437	732	54	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	437	732	54	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	CHEMBL49	732	54	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	CHEMBL49	732	54	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	DB00490	732	54	None	-7	29	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8394987
	DB00490	732	54	None	-21	29	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	8397408
	1524	2141	89	None	-39	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	197	2141	89	None	-39	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	3822	2141	89	None	-39	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	88	2141	89	None	-39	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	CHEMBL51	2141	89	None	-39	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	DB12465	2141	89	None	-39	52	Mouse	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394987
	1353	1872	85	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	1353	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	1353	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	1353	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	3559	1872	85	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	3559	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	3559	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	3559	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	86	1872	85	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	86	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	86	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	86	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	CHEMBL54	1872	85	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	CHEMBL54	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	CHEMBL54	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	CHEMBL54	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	DB00502	1872	85	None	-263	86	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9298538
	DB00502	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	7908055
	DB00502	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8397408
	DB00502	1872	85	None	-120	86	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	8997630
	115	3720	78	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
	4296	3720	78	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
	CHEMBL274866	3720	78	None	-8	27	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8394362
	1355	1972	82	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
	142	1972	82	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
	CHEMBL478	1972	82	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
	DB12110	1972	82	None	-21	16	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8394362
	282	1386	0	None	-3548	7	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8397408
	522609	1386	0	None	-3548	7	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8397408
	12	1518	14	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
	6918513	1518	14	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
	CHEMBL267615	1518	14	None	-13	7	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	5	1	2	2.8	CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC	10715164
	135398745	2858	108	None	-95	66	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
	47	2858	108	None	-95	66	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
	CHEMBL715	2858	108	None	-95	66	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
	DB00334	2858	108	None	-95	66	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	9720804
	1220	186	46	None	-199	45	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
	31	186	46	None	-199	45	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
	7	186	46	None	-199	45	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
	CHEMBL56	186	46	None	-199	45	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394987
	1524	2141	89	None	-173	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	197	2141	89	None	-173	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	3822	2141	89	None	-173	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	88	2141	89	None	-173	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	CHEMBL51	2141	89	None	-173	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	DB12465	2141	89	None	-173	52	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8394362
	267	1414	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
	9847259	1414	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
	CHEMBL4214961	1414	0	None	1	2	Rat	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	7	2	5	4.6	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1ccc(c(c1Cl)Cl)O	10327430
	1346	83	108	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
	280	83	108	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
	9899402	83	108	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
	CHEMBL9666	83	108	None	-147	9	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	192	2	1	3	1.1	COc1ccccc1N1CCNCC1	8394362
	10531	1387	18	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	121	1387	18	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	888	1387	18	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	CHEMBL1732	1387	18	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	DB00320	1387	18	None	-87	24	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8397408
	6918515	2564	33	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
	71	2564	33	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
	CHEMBL7318	2564	33	None	-4	7	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	5	1	2	3.9	COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1	10715164
	1150	3805	116	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
	125	3805	116	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
	CHEMBL6640	3805	116	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
	DB08653	3805	116	None	-6	25	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8226867
	135398745	2858	108	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
	135398745	2858	108	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
	47	2858	108	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
	47	2858	108	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
	CHEMBL715	2858	108	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
	CHEMBL715	2858	108	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
	DB00334	2858	108	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	7908055
	DB00334	2858	108	None	-34	66	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	8997630
	277	1269	55	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	2913	1269	55	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	765	1269	55	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	CHEMBL516	1269	55	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	DB00434	1269	55	None	-70	46	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8226867
	108029	3349	50	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
	23	3349	50	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
	CHEMBL18785	3349	50	None	-125	13	Mouse	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8394987
	3652	4022	72	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	57	4022	72	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	60809	4022	72	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	CHEMBL21536	4022	72	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	DB15357	4022	72	None	-6	18	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	1220	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
	1220	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
	1220	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
	1220	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
	31	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
	31	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
	31	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
	31	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
	7	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
	7	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
	7	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
	7	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
	CHEMBL56	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	11414657
	CHEMBL56	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8226867
	CHEMBL56	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9298538
	CHEMBL56	186	46	None	-199	45	Human	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	9720804
	180	397	50	None	-125	39	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	200	397	50	None	-125	39	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	2160	397	50	None	-125	39	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	CHEMBL629	397	50	None	-125	39	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	DB00321	397	50	None	-125	39	Rat	7.0	pKi	None	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8394362
	10257	726	28	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
	144	726	28	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
	CHEMBL416526	726	28	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
	DB01445	726	28	None	-39	19	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	204	3	2	2	2.0	CN(CCc1c[nH]c2c1cc(O)cc2)C	8394987
	37459	733	10	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
	62	733	10	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
	CHEMBL8514	733	10	None	-194	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8397408
	282	1386	0	None	-1122	7	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8394987
	522609	1386	0	None	-1122	7	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	8394987
	3294	1967	106	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	71360	1967	106	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	87	1967	106	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	CHEMBL14376	1967	106	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	DB04946	1967	106	None	-41	45	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	11750183
	135	2486	38	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	1796	2486	38	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	4184	2486	38	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	CHEMBL6437	2486	38	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	DB06148	2486	38	None	-21	58	Mouse	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394987
	1613	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	1613	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	205	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	205	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	3964	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	3964	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	CHEMBL831	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	CHEMBL831	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	DB00408	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	7908055
	DB00408	2306	44	None	-14	45	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	8394362
	5074	3268	75	None	-74	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
	5074	3268	75	None	-74	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
	97	3268	75	None	-74	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
	97	3268	75	None	-74	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
	CHEMBL267777	3268	75	None	-74	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
	CHEMBL267777	3268	75	None	-74	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
	DB12693	3268	75	None	-74	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	11414657
	DB12693	3268	75	None	-74	30	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8226867
	1342	36	42	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
	3	36	42	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
	CHEMBL277120	36	42	None	-33	19	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8226867
	100	3733	52	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	2637	3733	52	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	5452	3733	52	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	CHEMBL479	3733	52	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	DB00679	3733	52	None	-28	56	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	15821958
	135	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	135	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	1796	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	1796	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	4184	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	4184	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	CHEMBL6437	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	CHEMBL6437	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	DB06148	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8394362
	DB06148	2486	38	None	-50	58	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8397408
	62865	1243	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	746	1243	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	84	1243	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	CHEMBL2104153	1243	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	DB09000	1243	0	None	-7	15	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	12527336
	209	2996	94	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	2113	2996	94	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	4748	2996	94	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	CHEMBL567	2996	94	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	DB00850	2996	94	None	-31	23	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	15821958
	2470	3583	46	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	3300	3583	46	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	5265	3583	46	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	99	3583	46	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	CHEMBL267930	3583	46	None	-1096	60	Mouse	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8394987
	100	3733	52	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	2637	3733	52	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	5452	3733	52	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	CHEMBL479	3733	52	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	DB00679	3733	52	None	-18	56	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	7908055
	277	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	277	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	2913	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	2913	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	765	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	765	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	CHEMBL516	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	CHEMBL516	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	DB00434	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8394362
	DB00434	1269	55	None	-43	46	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	8397408
	1043	1545	13	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	149	1545	13	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	8223	1545	13	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	CHEMBL442	1545	13	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	DB00696	1545	13	None	-549	29	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8394987
	1220	186	46	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
	1220	186	46	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
	31	186	46	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
	31	186	46	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
	7	186	46	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
	7	186	46	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
	CHEMBL56	186	46	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8394362
	CHEMBL56	186	46	None	-75	45	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8397408
	191	399	92	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	201	399	92	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	2170	399	92	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	CHEMBL1113	399	92	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	DB00543	399	92	None	-19	29	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	7908055
	135398737	942	89	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	38	942	89	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	722	942	89	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	CHEMBL42	942	89	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	DB00363	942	89	None	-9	92	Mouse	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394987
	134	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	134	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	134	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	1775	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	1775	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	1775	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	9681	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	9681	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	9681	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	CHEMBL1065	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	CHEMBL1065	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	CHEMBL1065	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	DB00247	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11414657
	DB00247	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8226867
	DB00247	2468	19	None	-24	68	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9298538
	135	2486	38	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	1796	2486	38	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	4184	2486	38	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	CHEMBL6437	2486	38	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	DB06148	2486	38	None	-83	58	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9298538
	2470	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	2470	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	2470	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	3300	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	3300	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	3300	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	5265	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	5265	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	5265	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	99	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	99	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	99	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	CHEMBL267930	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	11414657
	CHEMBL267930	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8226867
	CHEMBL267930	3583	46	None	-1258	60	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9298538
	135398737	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	135398737	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	135398737	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	38	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	38	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	38	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	722	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	722	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	722	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	CHEMBL42	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	CHEMBL42	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	CHEMBL42	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	DB00363	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	11414657
	DB00363	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15821958
	DB00363	942	89	None	-13	92	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9720804
	10171	57	15	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
	272	57	15	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
	CHEMBL274384	57	15	None	-11	6	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8226867
	37459	733	10	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
	62	733	10	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
	CHEMBL8514	733	10	None	-74	25	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	8394987
	279	1623	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
	49381	1623	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
	CHEMBL63756	1623	26	None	-6	18	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	15821958
	133	2450	48	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	1723	2450	48	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	28693	2450	48	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	CHEMBL19215	2450	48	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	DB13520	2450	48	None	-36	43	Mouse	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394987
	145	140	48	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	1832	140	48	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	CHEMBL7257	140	48	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	DB14010	140	48	None	-4	30	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	8394362
	1342	36	42	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
	3	36	42	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
	CHEMBL277120	36	42	None	-13	19	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8394362
	2726	904	64	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	2726	904	64	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	621	904	64	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	621	904	64	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	83	904	64	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	83	904	64	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	CHEMBL71	904	64	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	CHEMBL71	904	64	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	DB00477	904	64	None	-13	73	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	DB00477	904	64	None	-13	73	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	206	2447	10	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
	68848	2447	10	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
	CHEMBL12314	2447	10	None	-16	25	Mouse	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394987
	209	2996	94	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	2113	2996	94	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	4748	2996	94	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	CHEMBL567	2996	94	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	DB00850	2996	94	None	-25	23	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	7908055
	31101	719	39	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	35	719	39	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	403	719	39	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	CHEMBL493	719	39	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	DB01200	719	39	None	-25	36	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	8394362
	1150	3805	116	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
	125	3805	116	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
	CHEMBL6640	3805	116	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
	DB08653	3805	116	None	1	25	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8394362
	135398737	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	135398737	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	135398737	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	135398737	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	38	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	38	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	38	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	38	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	722	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	722	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	722	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	722	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	CHEMBL42	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	CHEMBL42	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	CHEMBL42	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	CHEMBL42	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	DB00363	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	7908055
	DB00363	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8394362
	DB00363	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8397408
	DB00363	942	89	None	-7	92	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	8997630
	3294	1967	106	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	71360	1967	106	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	87	1967	106	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	CHEMBL14376	1967	106	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	DB04946	1967	106	None	-21	45	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	8997630
	163839	2899	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
	268	2899	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
	CHEMBL55171	2899	0	None	-1	7	Rat	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	10327430
	5074	3268	75	None	-38	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
	97	3268	75	None	-38	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
	CHEMBL267777	3268	75	None	-38	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
	DB12693	3268	75	None	-38	30	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8394362
	206	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
	206	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
	206	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
	206	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
	68848	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
	68848	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
	68848	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
	68848	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
	CHEMBL12314	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	11414657
	CHEMBL12314	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8226867
	CHEMBL12314	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9298538
	CHEMBL12314	2447	10	None	-10	25	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9720804
	2470	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	2470	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	3300	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	3300	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	5265	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	5265	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	99	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	99	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	CHEMBL267930	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	7908055
	CHEMBL267930	3583	46	None	-389	60	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8397408
	1212	1624	45	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	204	1624	45	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	3372	1624	45	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	CHEMBL726	1624	45	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	DB00623	1624	45	None	-18	66	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	15821958
	134	2468	19	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	134	2468	19	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	1775	2468	19	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	1775	2468	19	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	9681	2468	19	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	9681	2468	19	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	CHEMBL1065	2468	19	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	CHEMBL1065	2468	19	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	DB00247	2468	19	None	-9	68	Mouse	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394987
	DB00247	2468	19	None	-18	68	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8394362
	133	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	133	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	1723	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	1723	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	28693	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	28693	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	CHEMBL19215	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	CHEMBL19215	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	DB13520	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8394362
	DB13520	2450	48	None	-16	43	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8397408
	206	2447	10	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
	68848	2447	10	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
	CHEMBL12314	2447	10	None	-6	25	Rat	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8394362
	10171	57	15	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
	272	57	15	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
	CHEMBL274384	57	15	None	-5	6	Mouse	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	3	1	2	3.7	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC	8394987
	10531	1387	18	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	121	1387	18	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	888	1387	18	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	CHEMBL1732	1387	18	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	DB00320	1387	18	None	-23	24	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	8226867
	154	2317	0	None	-12	4	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	638252	2317	0	None	-12	4	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	1212	1624	45	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	204	1624	45	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	3372	1624	45	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	CHEMBL726	1624	45	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	DB00623	1624	45	None	-15	66	Rat	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7908055
	107	141	116	None	-9	31	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
	1833	141	116	None	-9	31	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
	CHEMBL8165	141	116	None	-9	31	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394987
	4106	2456	16	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
	5358812	2456	16	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
	89	2456	16	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
	CHEMBL93240	2456	16	None	-15	34	Mouse	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394987
	122	1404	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	156314	1404	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	CHEMBL1332062	1404	9	None	1	11	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	5	139	66	None	-11	55	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
	5202	139	66	None	-11	55	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
	CHEMBL39	139	66	None	-11	55	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
	DB08839	139	66	None	-11	55	Mouse	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8394987
	279	1623	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
	49381	1623	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
	CHEMBL63756	1623	26	None	1	18	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	7908055
	283	3069	47	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
	4847	3069	47	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
	CHEMBL18331	3069	47	None	-4	12	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	9298538
	2865	4064	67	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	59	4064	67	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	60854	4064	67	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	CHEMBL708	4064	67	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	DB00246	4064	67	None	-12	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	15821958
	103	4074	56	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	2875	4074	56	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	5736	4074	56	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	CHEMBL285802	4074	56	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	DB09225	4074	56	None	-6	54	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	15821958
	2389	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	2389	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	5073	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	5073	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	96	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	96	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	CHEMBL85	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	CHEMBL85	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	DB00734	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	15821958
	DB00734	3267	114	None	-9	68	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	9720804
	133	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	133	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	133	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	1723	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	1723	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	1723	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	28693	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	28693	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	28693	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	CHEMBL19215	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	CHEMBL19215	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	CHEMBL19215	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	DB13520	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	11414657
	DB13520	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8226867
	DB13520	2450	48	None	-10	43	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	9298538
	2105	2993	34	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	47811	2993	34	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	48	2993	34	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	CHEMBL531	2993	34	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	DB01186	2993	34	None	-5	33	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	8394362
	1588	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	1588	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	28864	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	28864	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	43	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	43	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	CHEMBL157138	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	CHEMBL157138	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	DB00589	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8394362
	DB00589	2284	24	None	-9	44	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	8397408
	103	4074	56	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	2875	4074	56	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	5736	4074	56	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	CHEMBL285802	4074	56	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	DB09225	4074	56	None	-2	54	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	7908055
	5	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
	5	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
	5	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
	5	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
	5	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
	5202	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
	5202	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
	5202	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
	5202	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
	5202	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
	CHEMBL39	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
	CHEMBL39	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
	CHEMBL39	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
	CHEMBL39	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
	CHEMBL39	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
	DB08839	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11414657
	DB08839	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12527336
	DB08839	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8226867
	DB08839	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9298538
	DB08839	139	66	None	-3	55	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	9720804
	107	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
	107	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
	107	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
	1833	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
	1833	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
	1833	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
	CHEMBL8165	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	11414657
	CHEMBL8165	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8226867
	CHEMBL8165	141	116	None	-3	31	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	9298538
	4106	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
	4106	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
	4106	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
	4106	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
	5358812	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
	5358812	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
	5358812	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
	5358812	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
	89	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
	89	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
	89	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
	89	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
	CHEMBL93240	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	11414657
	CHEMBL93240	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8226867
	CHEMBL93240	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9298538
	CHEMBL93240	2456	16	None	-4	34	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9720804
	107	141	116	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
	107	141	116	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
	1833	141	116	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
	1833	141	116	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
	CHEMBL8165	141	116	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8394362
	CHEMBL8165	141	116	None	-1	31	Rat	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8397408
	1809	134	28	None	-12	37	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
	4	134	28	None	-12	37	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
	CHEMBL18840	134	28	None	-12	37	Mouse	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394987
	4106	2456	16	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
	5358812	2456	16	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
	89	2456	16	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
	CHEMBL93240	2456	16	None	-2	34	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	8394362
	101	3750	18	None	-1	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
	55752	3750	18	None	-1	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
	CHEMBL35057	3750	18	None	-1	14	Rat	9.2	pKi	None	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	7908055
	1809	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
	1809	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
	1809	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	1809	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
	4	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
	4	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
	4	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	4	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
	CHEMBL18840	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	11414657
	CHEMBL18840	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8226867
	CHEMBL18840	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9298538
	CHEMBL18840	134	28	None	-7	37	Human	9.5	pKi	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	9720804
	1809	134	28	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
	1809	134	28	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408
	4	134	28	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
	4	134	28	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408
	CHEMBL18840	134	28	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8394362
	CHEMBL18840	134	28	None	-2	37	Rat	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8397408

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)