Ligand source activities (1 row/activity)



Get vendors


Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
44377942 57138 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 530 6 2 5 5.9 O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F 10.1021/jm1013693
CHEMBL165572 57138 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 530 6 2 5 5.9 O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F 10.1021/jm1013693
44355628 24687 0 None -5 2 Rat 6.0 pIC50 = 6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
CHEMBL134567 24687 0 None -5 2 Rat 6.0 pIC50 = 6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
10411653 24205 0 None -208 2 Rat 5.0 pIC50 = 5 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
CHEMBL134151 24205 0 None -208 2 Rat 5.0 pIC50 = 5 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
10410730 24399 0 None -6 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
CHEMBL134307 24399 0 None -6 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
10048220 25969 0 None -109 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL135704 25969 0 None -109 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10322995 114751 0 None -134 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
CHEMBL334832 114751 0 None -134 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
10003482 165179 0 None -158 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL424643 165179 0 None -158 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10364891 26025 0 None -33 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
CHEMBL135792 26025 0 None -33 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
192345 26016 6 None -12022 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL135775 26016 6 None -12022 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10393397 22582 0 None -6 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL132807 22582 0 None -6 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
10367704 22128 0 None -25 2 Rat 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL132408 22128 0 None -25 2 Rat 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10094520 24539 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
CHEMBL134433 24539 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
15698118 204413 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 537 10 2 6 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL86067 204413 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 537 10 2 6 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm1013693
44355660 21342 0 None -89 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL131676 21342 0 None -89 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
11743704 114986 0 None -3 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
CHEMBL335179 114986 0 None -3 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
10026268 116417 0 None -173 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
CHEMBL338505 116417 0 None -173 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
10322504 26163 0 None -19 2 Rat 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135929 26163 0 None -19 2 Rat 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10095493 25828 0 None -93 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
CHEMBL135521 25828 0 None -93 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
11754335 25084 0 None -186 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
CHEMBL134901 25084 0 None -186 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
1610 2305 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
3941 2305 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
3961 2305 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
590 2305 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
CHEMBL191 2305 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
DB00678 2305 89 None -8 9 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
44355662 26243 0 None -125 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL135999 26243 0 None -125 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
10411101 165102 0 None -676 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
CHEMBL424465 165102 0 None -676 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
19742811 57105 0 None 1 3 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL165354 57105 0 None 1 3 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
130762 97782 9 None 1 6 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm1013693
CHEMBL274447 97782 9 None 1 6 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm1013693
192567 116139 6 None -223 2 Rat 6.7 pIC50 = 6.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL337007 116139 6 None -223 2 Rat 6.7 pIC50 = 6.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
10366811 24607 0 None -31 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
CHEMBL134491 24607 0 None -31 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
11744592 114991 0 None -33 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
CHEMBL335228 114991 0 None -33 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
10409549 115465 0 None -104 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL335514 115465 0 None -104 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10027636 24375 0 None -70 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL134286 24375 0 None -70 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
71455883 83336 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1021/jm1013693
CHEMBL2205685 83336 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1021/jm1013693
10048602 25830 0 None -37 2 Rat 4.6 pIC50 = 4.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
CHEMBL135522 25830 0 None -37 2 Rat 4.6 pIC50 = 4.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
9914666 116157 0 None -3388 2 Rat 5.6 pIC50 = 5.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL337086 116157 0 None -3388 2 Rat 5.6 pIC50 = 5.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
9846535 57196 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 427 5 2 4 5.4 O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 10.1021/jm1013693
CHEMBL166143 57196 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 427 5 2 4 5.4 O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 10.1021/jm1013693
10326140 116138 0 None -2884 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL337006 116138 0 None -2884 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
10365283 25634 0 None -416 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135345 25634 0 None -416 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10393717 115586 0 None -524 2 Rat 6.4 pIC50 = 6.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL335722 115586 0 None -524 2 Rat 6.4 pIC50 = 6.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
10344571 116101 0 None -125 2 Rat 5.4 pIC50 = 5.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336773 116101 0 None -125 2 Rat 5.4 pIC50 = 5.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10027714 114925 0 None -398 2 Rat 5.3 pIC50 = 5.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL335066 114925 0 None -398 2 Rat 5.3 pIC50 = 5.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10004112 25311 0 None -93 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL135089 25311 0 None -93 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10344052 116094 0 None -107 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336738 116094 0 None -107 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10437543 26047 0 None -7 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL135819 26047 0 None -7 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
10414429 115484 0 None -363 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
CHEMBL335535 115484 0 None -363 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
10434876 116105 0 None -7 2 Rat 6.2 pIC50 = 6.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336808 116105 0 None -7 2 Rat 6.2 pIC50 = 6.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10026868 23640 0 None -331 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL133653 23640 0 None -331 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
10456041 25636 0 None -186 2 Rat 6.1 pIC50 = 6.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135346 25636 0 None -186 2 Rat 6.1 pIC50 = 6.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10095589 115007 0 None -851 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL335289 115007 0 None -851 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10345459 116257 0 None -43 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
CHEMBL337663 116257 0 None -43 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
10250898 117971 0 None -37 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
CHEMBL341407 117971 0 None -37 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
10071193 202611 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism against A-2 induced contraction of aortic rings of rabbit.Antagonism against A-2 induced contraction of aortic rings of rabbit.
ChEMBL 427 7 1 4 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 10.1021/jm9508853
CHEMBL71485 202611 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism against A-2 induced contraction of aortic rings of rabbit.Antagonism against A-2 induced contraction of aortic rings of rabbit.
ChEMBL 427 7 1 4 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 10.1021/jm9508853
6918 1010 29 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
9804984 1010 29 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL189568 1010 29 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
6918 1010 29 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
9804984 1010 29 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
CHEMBL189568 1010 29 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
6918 1010 29 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
9804984 1010 29 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
CHEMBL189568 1010 29 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
1610 2305 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2305 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2305 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2305 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2305 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2305 89 None -309 9 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
36736 3405 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
598 3405 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
6324663 3405 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
CHEMBL356431 3405 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
123805 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
46878481 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
5578 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
582 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
CHEMBL3545347 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
DB11720 413 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
8374 2866 36 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
9937291 2866 36 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
CHEMBL34124 2866 36 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
DB16266 2866 36 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
8374 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
8374 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
8374 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
9937291 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
9937291 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
9937291 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
CHEMBL34124 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
CHEMBL34124 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
CHEMBL34124 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
DB16266 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
DB16266 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
DB16266 2866 36 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
114899 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
114899 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
114899 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
596 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
596 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
596 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
CHEMBL1188080 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
CHEMBL1188080 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
CHEMBL1188080 2959 11 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
36736 3405 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
598 3405 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
6324663 3405 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
CHEMBL356431 3405 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
123794 878 40 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
3944 878 40 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
594 878 40 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
CHEMBL1885579 878 40 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
6894 414 0 None 2 3 Human 9.9 pIC50 = 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938
91691124 414 0 None 2 3 Human 9.9 pIC50 = 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938


Get vendors


Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
44348523 112667 0 None - 0 Rat 10.3 pIC50 = 10.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 112667 0 None - 0 Rat 10.3 pIC50 = 10.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
11930 1002 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
15780052 1002 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
CHEMBL289472 1002 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
10033116 206485 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98665 206485 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
11765177 116494 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 116494 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
16133225 415 47 None -2 6 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
172198 415 47 None -2 6 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
2504 415 47 None -2 6 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
45266664 415 47 None -2 6 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
5272 415 47 None -2 6 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL408403 415 47 None -2 6 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
DB11842 415 47 None -2 6 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL385433 210593 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2016.03.006
10259841 15967 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 15967 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10417195 108579 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 108579 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
10078554 116454 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116454 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10440174 167240 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 767 17 1 9 8.0 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL430659 167240 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 767 17 1 9 8.0 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL385189 210586 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cccs1)C(=O)O 10.1021/jm00108a043
10078800 108691 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 108691 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9853391 116326 1 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116326 1 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9853391 116326 1 None - 0 Human 9.9 pIC50 = 9.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL338027 116326 1 None - 0 Human 9.9 pIC50 = 9.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL2391146 208657 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human angiotensin AT2 receptor by radioligand displacement assayBinding affinity to human angiotensin AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
10101351 168088 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168088 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259525 15428 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15428 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372810 105708 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 105708 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
10078800 108691 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 108691 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10395335 116568 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116568 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10033136 15882 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 15882 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
19430477 206380 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 8.1 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 10.1021/jm00015a016
CHEMBL98047 206380 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 8.1 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 10.1021/jm00015a016
10259468 117964 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 117964 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101606 15580 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15580 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10032988 116404 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116404 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10440179 106902 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL317962 106902 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10078780 116403 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116403 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259468 117964 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 117964 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259265 109541 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissues.Inhibitory concentration against AT1 receptor from rat adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 109541 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissues.Inhibitory concentration against AT1 receptor from rat adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10372659 117574 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 117574 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10327728 97658 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 97658 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10078554 116454 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116454 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10033116 206485 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98665 206485 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
44348523 112667 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 112667 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
10032877 15359 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15359 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
183134 203126 13 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL7550 203126 13 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10259525 15428 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15428 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010071 116833 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116833 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292111 203027 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 203027 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL2392353 208659 6 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human AT2 receptor by radioligand displacement assayBinding affinity to human AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10033136 15882 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 15882 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10439837 16162 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16162 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10032820 116788 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 116788 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
9853391 116326 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116326 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101690 116348 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116348 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10440144 116381 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116381 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439715 116521 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 116521 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314761 102368 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102368 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
44315344 104589 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 104589 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315078 203038 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 203038 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
15780085 117634 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL34082 117634 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10440144 116381 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116381 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10032988 116404 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116404 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101351 168088 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168088 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315078 203038 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 203038 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10033126 167563 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL433005 167563 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10078780 116403 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116403 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372451 116778 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 116778 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462683 112770 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 112770 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44283480 99989 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290768 99989 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10259265 109541 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 109541 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10259265 109541 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL323506 109541 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462933 16687 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16687 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
19754068 102247 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL304946 102247 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10101606 15580 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15580 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10101608 116515 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 116515 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
44315282 96163 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96163 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
44315351 104393 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104393 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
9896750 4101 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm00015a016
CHEMBL100119 4101 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm00015a016
10372550 163953 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 163953 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439715 116521 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 116521 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987414 116535 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 116535 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
11765177 116494 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 116494 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10032851 16641 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16641 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314761 102368 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102368 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
9896750 4101 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm9504722
CHEMBL100119 4101 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm9504722
10032877 15359 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15359 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10009984 112668 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 112668 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
10078475 112818 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 112818 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987414 116535 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 116535 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010164 116881 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 116881 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765560 15347 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15347 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314822 102463 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102463 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9895877 53591 1 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 653 12 2 8 7.1 CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm9504722
CHEMBL160494 53591 1 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 653 12 2 8 7.1 CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm9504722
10439858 16667 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16667 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 16732 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16732 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
10010071 116833 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116833 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292111 203027 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 203027 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19754061 102248 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL304947 102248 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
10462573 116495 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 116495 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10395335 116568 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116568 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44315349 60056 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60056 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10394859 17232 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17232 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
2583 3705 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
592 3705 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
65999 3705 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
CHEMBL1017 3705 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
DB00966 3705 115 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
10373120 117085 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117085 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
10394859 17232 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17232 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 104393 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104393 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
15780090 99976 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290669 99976 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10101608 116515 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 116515 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10259841 15967 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 15967 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372659 117574 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 117574 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314822 102463 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102463 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10373120 117085 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117085 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
44315144 96131 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96131 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10032851 16641 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16641 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395076 168000 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168000 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9874508 202964 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 202964 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9874508 202964 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
CHEMBL73876 202964 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
44338708 109942 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL324629 109942 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
22850667 199106 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL60071 199106 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10032820 116788 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 116788 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10462683 112770 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 112770 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314823 161326 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161326 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL938 214120 24 None -1 2 Human 9.4 pIC50 = 9.4 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
9809637 202145 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68618 202145 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
9830680 100163 0 None - 1 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
CHEMBL292150 100163 0 None - 1 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
15780094 99336 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285433 99336 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL384352 210567 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 10.1021/jm00065a013
9917295 102472 13 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306407 102472 13 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
10417321 15427 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15427 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439819 169311 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169311 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292113 95574 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 95574 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10078800 108691 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 108691 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10485034 106689 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 719 17 1 9 7.1 CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL316503 106689 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 719 17 1 9 7.1 CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
15292113 95574 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 95574 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10462598 113624 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 113624 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10259447 16732 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16732 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL938 214120 24 None -1 2 Human 9.3 pIC50 = 9.3 Binding
Inhibition of human angiotensin II AT2 receptorInhibition of human angiotensin II AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmc.2010.07.034
10462933 16687 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16687 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462598 113624 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 113624 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10009984 112668 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 112668 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
15292112 102462 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102462 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44314780 102591 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 102591 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10101690 116348 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116348 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
8374 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
9937291 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
CHEMBL34124 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
DB16266 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
10327309 113379 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113379 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10372451 116778 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 116778 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
8374 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
9937291 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
CHEMBL34124 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
DB16266 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
44338834 7761 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL108981 7761 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44338834 7761 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL108981 7761 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44303887 201621 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64861 201621 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
8374 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
9937291 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL34124 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
DB16266 2866 36 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
44315344 104589 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 104589 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
16133225 415 47 None -2 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
172198 415 47 None -2 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
2504 415 47 None -2 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
45266664 415 47 None -2 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
5272 415 47 None -2 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
CHEMBL408403 415 47 None -2 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
DB11842 415 47 None -2 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
11765454 117552 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 117552 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10349897 113916 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 113916 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315058 70095 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70095 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315059 202996 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 202996 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10101606 15580 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15580 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL385283 210590 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
19430475 202540 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71125 202540 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
9940350 203040 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL74573 203040 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
9851889 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL302102 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
9940350 203040 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74573 203040 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10031067 99875 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL289614 99875 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
10031067 99875 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL289614 99875 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
10031067 99875 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL289614 99875 3 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
44283174 99599 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL287250 99599 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851889 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
CHEMBL302102 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
9851889 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
CHEMBL302102 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
9851889 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
CHEMBL302102 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
10395076 168000 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168000 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315058 70095 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70095 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851889 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44303886 100400 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293660 100400 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9851889 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL302102 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
9851889 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
CHEMBL302102 101591 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
9851889 101591 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
CHEMBL302102 101591 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
44315057 203111 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 203111 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10078475 112818 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 112818 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44283175 119851 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35324 119851 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44315304 203291 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 203291 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
44314823 161326 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161326 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
9874508 202964 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 202964 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10439819 169311 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169311 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44338697 109158 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL322471 109158 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
10372550 163953 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 163953 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
15292112 102462 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102462 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44314780 102591 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 102591 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10462573 116495 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 116495 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL414533 211378 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
10259265 109541 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 109541 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10327309 113379 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113379 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10439837 16162 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16162 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
9892451 48461 17 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155836 48461 17 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
10010164 116881 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 116881 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10032988 116404 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116404 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765454 117552 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 117552 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10100951 114533 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 114533 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
20647138 99993 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL290829 99993 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
9918412 202550 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71172 202550 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
19430479 202557 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71220 202557 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10462053 167483 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 664 15 4 8 5.9 CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL432378 167483 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 664 15 4 8 5.9 CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10327728 97658 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 97658 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315282 96163 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96163 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
9917399 101663 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL302519 101663 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
9917399 101663 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
CHEMBL302519 101663 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
44315349 60056 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60056 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44311675 101671 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302579 101671 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311676 102574 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307318 102574 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311412 104837 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311625 104837 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311072 202476 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70789 202476 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311736 202497 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70867 202497 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311452 202790 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL72595 202790 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
15780095 98130 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL276853 98130 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
15780091 120470 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35638 120470 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851082 100538 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(01)80554-0
CHEMBL294512 100538 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(01)80554-0
9810305 98107 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL276674 98107 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9810305 98107 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL276674 98107 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
1037 1542 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
3940 1542 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
5281037 1542 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
588 1542 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
CHEMBL813 1542 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
DB00876 1542 65 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
9810305 98107 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98107 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44315144 96131 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96131 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851082 100538 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL294512 100538 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
10395395 106797 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL317159 106797 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10033013 111149 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 750 17 1 10 7.3 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm00015a016
CHEMBL328602 111149 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 750 17 1 10 7.3 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm00015a016
9937227 200477 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
CHEMBL60942 200477 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
10078661 206496 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 17 1 9 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98746 206496 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 17 1 9 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10259277 206563 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 715 18 1 9 7.4 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 10.1021/jm00015a016
CHEMBL99112 206563 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 715 18 1 9 7.4 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 10.1021/jm00015a016
44315304 203291 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 203291 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315057 203111 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 203111 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44322202 106375 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 692 17 4 8 6.7 CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL314506 106375 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 692 17 4 8 6.7 CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44322203 106438 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 650 13 4 8 5.4 CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL314827 106438 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 650 13 4 8 5.4 CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44321791 204877 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 698 14 4 8 6.0 CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89053 204877 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 698 14 4 8 6.0 CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10078554 116454 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116454 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765560 15347 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15347 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10417321 15427 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15427 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9810305 98107 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98107 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
10485116 116340 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116340 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
18965174 100388 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 507 12 1 3 5.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293625 100388 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 507 12 1 3 5.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9870559 46590 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 8 1 4 5.6 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL154057 46590 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 8 1 4 5.6 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 10.1016/S0960-894X(01)81122-7
19939495 206080 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory concentration against AT2 receptor from rat adrenal tissues.Inhibitory concentration against AT2 receptor from rat adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 206080 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory concentration against AT2 receptor from rat adrenal tissues.Inhibitory concentration against AT2 receptor from rat adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10010071 116833 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116833 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL216061 207561 10 None - 2 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00108a043
10395335 116568 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116568 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10349897 113916 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 113916 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439858 16667 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16667 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315060 102570 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 102570 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL938 214120 24 None -1 2 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm00065a013
15780089 99335 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285432 99335 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10349732 118235 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL341828 118235 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
10101351 168088 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168088 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259489 16722 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 16722 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
22850669 201288 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63109 201288 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10321941 137606 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1021/jm00108a043
CHEMBL37679 137606 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1021/jm00108a043
20647138 99993 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
CHEMBL290829 99993 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
10033136 15882 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 15882 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10394859 17232 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17232 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
20647138 99993 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL290829 99993 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
19430442 202465 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL70726 202465 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
10078663 206042 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL96075 206042 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
10100951 114533 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL334300 114533 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10078663 206042 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL96075 206042 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44381553 119817 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352947 119817 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10100951 114533 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 114533 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44315350 104726 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 104726 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10417321 15427 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15427 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44348523 112667 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 112667 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
9870914 201627 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64881 201627 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44299731 416 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
585 416 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
CHEMBL56448 416 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
10395076 168000 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168000 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315059 202996 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 202996 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19430462 102498 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306638 102498 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
44321824 203842 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 642 13 4 8 5.5 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL81236 203842 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 642 13 4 8 5.5 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
22402434 48747 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 1 5 5.8 COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81122-7
CHEMBL156100 48747 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 1 5 5.8 COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81122-7
44311617 102053 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL304065 102053 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
44311538 102477 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL306435 102477 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311755 102646 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307866 102646 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311071 102927 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL308482 102927 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
44311752 104373 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL311018 104373 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
10005139 57284 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 10.1016/j.bmc.2010.10.043
CHEMBL1668008 57284 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 10.1016/j.bmc.2010.10.043
14403498 100549 3 None - 0 Rat 8.0 pIC50 = 8 Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomesBinding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL294558 100549 3 None - 0 Rat 8.0 pIC50 = 8 Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomesBinding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
44303640 198419 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 511 12 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59611 198419 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 511 12 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 10.1016/S0960-894X(01)80554-0
44303208 200850 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 555 12 1 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL61168 200850 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 555 12 1 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 10.1016/S0960-894X(01)80554-0
44210590 58391 0 None - 0 Rat 8.0 pIC50 = 8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168490 58391 0 None - 0 Rat 8.0 pIC50 = 8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10078475 112818 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 112818 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
18965184 201218 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 504 4 0 2 7.3 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL62806 201218 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 504 4 0 2 7.3 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
44330905 4329 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 746 19 1 8 8.2 CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 10.1021/jm00015a016
CHEMBL101455 4329 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 746 19 1 8 8.2 CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 10.1021/jm00015a016
9937227 200477 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
CHEMBL60942 200477 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
11755896 116458 0 None - 0 Rat 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 505 7 1 3 5.8 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL338709 116458 0 None - 0 Rat 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 505 7 1 3 5.8 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
11765541 118490 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342605 118490 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9988057 105668 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 831 10 5 15 3.3 CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C 10.1016/0960-894X(95)00477-B
CHEMBL313691 105668 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 831 10 5 15 3.3 CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C 10.1016/0960-894X(95)00477-B
44311496 202533 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL71069 202533 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
44379292 119815 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352934 119815 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
10077497 11249 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL1179757 11249 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL98426 11249 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
44328276 112217 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL330464 112217 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10077929 205604 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
CHEMBL93606 205604 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
15818748 99438 0 None - 0 Human 7.0 pIC50 = 7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL286134 99438 0 None - 0 Human 7.0 pIC50 = 7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311571 202740 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL72249 202740 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303248 201056 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 414 8 1 6 4.4 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C 10.1016/S0960-894X(01)80554-0
CHEMBL61976 201056 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 414 8 1 6 4.4 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C 10.1016/S0960-894X(01)80554-0
44311567 102526 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306922 102526 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311450 103611 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309365 103611 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311497 167283 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL430997 167283 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311664 202453 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70638 202453 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377125 55335 0 None - 0 Rat 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162148 55335 0 None - 0 Rat 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
1610 2305 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3941 2305 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3961 2305 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
590 2305 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
CHEMBL191 2305 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
DB00678 2305 89 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
44376747 119571 0 None - 0 Rat 5.0 pIC50 = 5 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350851 119571 0 None - 0 Rat 5.0 pIC50 = 5 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
9852384 99937 3 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL290214 99937 3 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
9852384 99937 3 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm049715t
CHEMBL290214 99937 3 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm049715t
9852384 99937 3 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL290214 99937 3 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
23583071 187625 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1450 7 8 31 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL499234 187625 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1450 7 8 31 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
164613196 184847 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 951 23 12 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4861538 184847 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 951 23 12 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
10440203 118469 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342492 118469 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44315058 70095 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70095 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315344 104589 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 104589 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10258694 112079 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
CHEMBL330165 112079 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
10233073 205889 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
CHEMBL95198 205889 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
10438523 206393 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL98126 206393 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
57380412 70169 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947129 70169 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
15296724 119500 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 462 7 2 5 4.3 COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 10.1016/S0960-894X(01)81122-7
CHEMBL350220 119500 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 462 7 2 5 4.3 COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 10.1016/S0960-894X(01)81122-7
11757357 206243 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97273 206243 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
23584461 178087 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1368 7 9 30 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL467872 178087 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1368 7 9 30 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
90663955 106280 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL 1280 38 16 17 0.0 CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O 10.1021/jm00065a013
CHEMBL3144487 106280 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL 1280 38 16 17 0.0 CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O 10.1021/jm00065a013
164625885 185674 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873899 185674 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44303458 167308 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 10.1016/S0960-894X(01)80554-0
CHEMBL431137 167308 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 10.1016/S0960-894X(01)80554-0
10417251 96444 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL265797 96444 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
19939453 111885 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL329679 111885 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10417251 96444 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL265797 96444 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL413925 211344 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 10.1021/jm00065a013
44381724 119789 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352771 119789 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
10259265 109541 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 109541 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
44315180 102410 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102410 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44373238 96627 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL267354 96627 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
44304147 100296 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
CHEMBL292939 100296 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
44315057 203111 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 203111 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44322236 112317 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 14 4 8 5.4 CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL330744 112317 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 14 4 8 5.4 CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44323447 106405 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 627 11 1 9 6.5 CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL314605 106405 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 627 11 1 9 6.5 CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379269 56858 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164769 56858 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10438745 106719 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
CHEMBL316655 106719 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
10349597 111115 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
CHEMBL328434 111115 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
10416475 205960 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
CHEMBL95579 205960 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
44300735 100280 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL292829 100280 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
46910582 69995 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945009 69995 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
19385652 47239 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15458 47239 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
19385680 98411 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
CHEMBL279103 98411 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
15696755 147479 1 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL39345 147479 1 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
44323530 205441 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 586 10 1 8 5.1 CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL92479 205441 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 586 10 1 8 5.1 CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10259395 26774 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL136465 26774 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381552 119768 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352629 119768 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
10349659 111042 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
CHEMBL327988 111042 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
10439275 167486 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
CHEMBL432392 167486 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
10054753 206395 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL98140 206395 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
44300615 195098 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL56549 195098 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
44373417 52089 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
CHEMBL159004 52089 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
57380649 70017 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945149 70017 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
11765394 118259 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
CHEMBL341986 118259 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
19939409 106663 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316299 106663 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
136026557 205125 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 617 11 1 10 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL90663 205125 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 617 11 1 10 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00477-B
44309903 202679 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71925 202679 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
19939495 206080 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 206080 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
44309903 202679 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL71925 202679 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
44270330 51454 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15847 51454 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
57380647 69996 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945010 69996 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10349791 111078 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
CHEMBL328176 111078 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
10008962 118755 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343719 118755 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
73347893 92180 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435828 92180 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10484866 31554 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL140619 31554 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44322097 106609 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 608 12 4 8 4.6 CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315994 106609 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 608 12 4 8 4.6 CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381425 119935 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353980 119935 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
18965154 100121 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 490 4 0 2 6.9 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL291818 100121 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 490 4 0 2 6.9 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
44303880 201275 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 12 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63046 201275 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 12 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 10.1016/S0960-894X(01)81007-6
44304044 201487 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 7 1 3 4.3 CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64280 201487 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 7 1 3 4.3 CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44323293 106537 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 629 14 1 9 6.8 CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O 10.1016/0960-894X(95)00477-B
CHEMBL315483 106537 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 629 14 1 9 6.8 CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O 10.1016/0960-894X(95)00477-B
44323357 111881 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 648 11 1 8 6.7 CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL329655 111881 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 648 11 1 8 6.7 CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323352 204814 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 9 1 9 5.2 CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88663 204814 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 9 1 9 5.2 CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10326775 111734 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
CHEMBL329089 111734 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
10483726 205832 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL94910 205832 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
10349506 206309 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
CHEMBL97615 206309 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
44300637 100445 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL293949 100445 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
10100413 196903 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57853 196903 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
15296725 164722 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 535 9 0 5 5.9 CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL423236 164722 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 535 9 0 5 5.9 CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
46910583 69994 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945008 69994 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44379348 164358 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL422374 164358 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10439172 205740 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
CHEMBL94355 205740 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
44377171 119693 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL352042 119693 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
15287894 54647 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16148 54647 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
44381739 58462 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168771 58462 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
44381739 58462 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL168771 58462 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10326797 205830 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
CHEMBL94905 205830 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
10326460 206357 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97897 206357 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
44327912 206384 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
CHEMBL98068 206384 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
44348153 117454 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
CHEMBL340367 117454 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
44210836 56200 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL163523 56200 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
73357017 92183 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435831 92183 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
44323532 205395 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL92206 205395 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
9830680 100163 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL292150 100163 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9830680 100163 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL292150 100163 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10372497 118228 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341783 118228 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9830680 100163 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL292150 100163 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
10078800 108691 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 108691 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9830680 100163 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
CHEMBL292150 100163 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
19754050 202173 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68786 202173 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
44381528 58669 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169009 58669 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10394995 110893 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
CHEMBL327191 110893 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
10077743 206208 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
CHEMBL97068 206208 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
44304148 201589 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 458 4 1 3 4.3 CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL64714 201589 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 458 4 1 3 4.3 CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 10.1016/S0960-894X(01)81007-6
22402428 48472 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 450 6 2 4 4.5 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155847 48472 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 450 6 2 4 4.5 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 10.1016/S0960-894X(01)81122-7
15229605 47875 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15517 47875 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
44323448 96389 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 559 10 2 8 5.1 CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL265291 96389 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 559 10 2 8 5.1 CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
11764788 100378 0 None - 1 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL293501 100378 0 None - 1 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9810305 98107 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98107 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
9895212 119122 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL346728 119122 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
44385182 60733 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL176473 60733 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10031920 107488 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
CHEMBL319404 107488 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
44372814 119272 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
CHEMBL348157 119272 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
44303888 201579 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64674 201579 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10390872 115633 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
CHEMBL335778 115633 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
44377086 119433 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349652 119433 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10101582 118858 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
CHEMBL344466 118858 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
5311348 100193 3 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1016/S0960-894X(01)81007-6
CHEMBL292277 100193 3 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1016/S0960-894X(01)81007-6
10484986 118179 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341715 118179 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
1952 2170 3 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
5312129 2170 3 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
CHEMBL1182768 2170 3 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
9960852 106685 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL316482 106685 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10416957 110998 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
CHEMBL327791 110998 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
10010125 206281 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97464 206281 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
136059719 188530 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1438 10 9 31 4.5 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL510526 188530 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1438 10 9 31 4.5 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
44300827 101284 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL299897 101284 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
44348355 112875 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
CHEMBL331797 112875 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
44311289 101742 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302964 101742 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311455 102258 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305017 102258 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311754 102510 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306761 102510 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311715 102708 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL308323 102708 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311435 202315 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL69721 202315 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311434 202415 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70370 202415 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311414 202513 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70935 202513 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311413 202638 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71639 202638 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311753 202895 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL73283 202895 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
3936 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
6603900 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL288174 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
44303191 167312 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 529 12 1 7 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL431162 167312 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 529 12 1 7 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 10.1016/S0960-894X(01)80554-0
3936 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
6603900 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
CHEMBL288174 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
3936 2171 28 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
6603900 2171 28 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
CHEMBL288174 2171 28 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
44322095 106514 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315327 106514 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10259841 15967 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 15967 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 16732 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16732 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
11765177 116494 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 116494 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
3936 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
6603900 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
CHEMBL288174 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
44372744 51857 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
CHEMBL158795 51857 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
3936 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
6603900 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
CHEMBL288174 2171 28 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
19430458 202366 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70100 202366 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
10010234 97962 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL275552 97962 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10078320 204779 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 684 13 4 8 5.8 CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL88446 204779 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 684 13 4 8 5.8 CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381426 119753 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352502 119753 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10349897 113916 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 113916 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259489 16722 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 16722 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
10078780 116403 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116403 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259468 117964 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 117964 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44309938 202587 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71388 202587 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
19802473 197018 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL58156 197018 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10439862 118254 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341934 118254 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010195 118666 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343142 118666 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10032851 16641 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16641 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10485116 116340 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL338101 116340 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
9895984 203031 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL74476 203031 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10485116 116340 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116340 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
10372810 105708 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 105708 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
44315180 102410 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102410 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9895984 203031 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 203031 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9892451 48461 17 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155836 48461 17 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
9895984 203031 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
CHEMBL74476 203031 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
10101284 205659 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL93907 205659 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10101284 205659 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL93907 205659 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
16133225 415 47 None -2 6 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
172198 415 47 None -2 6 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
2504 415 47 None -2 6 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
45266664 415 47 None -2 6 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
5272 415 47 None -2 6 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
CHEMBL408403 415 47 None -2 6 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
DB11842 415 47 None -2 6 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
11765560 15347 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15347 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10010071 116833 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116833 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10101284 205659 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 205659 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
44315060 102570 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 102570 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
10032877 15359 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15359 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10462683 112770 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 112770 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10417195 108579 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 108579 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
44310069 202034 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67801 202034 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10009984 112668 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 112668 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
44303884 201136 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62422 201136 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44381403 58839 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169968 58839 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10259657 118875 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344597 118875 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381413 120197 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354779 120197 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
9987414 116535 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 116535 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44311453 202330 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL69839 202330 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311557 202571 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71286 202571 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311558 203005 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74236 203005 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44303388 162345 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 539 12 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL417393 162345 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 539 12 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 10.1016/S0960-894X(01)80554-0
44303459 198593 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 586 13 1 10 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)80554-0
CHEMBL59728 198593 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 586 13 1 10 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)80554-0
44303197 200541 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 619 12 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60992 200541 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 619 12 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 10.1016/S0960-894X(01)80554-0
10394727 102575 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307321 102575 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
44210589 58273 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168413 58273 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
11765454 117552 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 117552 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10092454 99770 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II induced contractions in rabbit aortic ringsInhibition of Angiotensin II induced contractions in rabbit aortic rings
ChEMBL 401 7 2 5 4.9 CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00037a014
CHEMBL288705 99770 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II induced contractions in rabbit aortic ringsInhibition of Angiotensin II induced contractions in rabbit aortic rings
ChEMBL 401 7 2 5 4.9 CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00037a014
44303859 199296 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL60209 199296 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
9896877 59901 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL174080 59901 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
44311584 102294 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305239 102294 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
44311406 103317 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309081 103317 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10480819 21591 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 492 6 1 3 6.1 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL131940 21591 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 492 6 1 3 6.1 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
44311635 101741 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
CHEMBL302959 101741 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
44311499 202684 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL71953 202684 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44384389 129302 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
CHEMBL367569 129302 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
10429298 18699 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL128416 18699 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
44210864 147561 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39352 147561 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
9850811 154190 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39996 154190 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311616 101657 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL302485 101657 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311776 102528 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306924 102528 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10255071 162900 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 0 4 5.6 COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL419974 162900 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 0 4 5.6 COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
9981762 162902 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 5 0 3 5.6 COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL419979 162902 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 5 0 3 5.6 COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44379347 119968 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354338 119968 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44377075 119459 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349869 119459 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
15287882 49459 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15670 49459 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
22407453 49474 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15671 49474 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
9987311 116244 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337588 116244 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
14952914 154359 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 410 9 2 5 5.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 10.1021/jm00108a043
CHEMBL40089 154359 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 410 9 2 5 5.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 10.1021/jm00108a043
44338666 110456 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL326217 110456 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44379335 119703 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352137 119703 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
44379293 119771 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352639 119771 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
44376780 56195 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL163486 56195 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44300734 101323 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL300154 101323 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10049400 154889 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
CHEMBL40381 154889 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
44323358 112000 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 626 10 1 8 6.0 CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL329887 112000 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 626 10 1 8 6.0 CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
19939398 106837 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
CHEMBL317547 106837 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
10055534 156907 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL407919 156907 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
44338833 9074 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL110265 9074 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
15231091 93541 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24861 93541 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
15231091 93541 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL24861 93541 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL443325 212163 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSSC[C@H](C(=O)N[C@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C[C@H](CN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)SS2 10.1021/jm00065a013
44303857 100330 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
CHEMBL293195 100330 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
10417144 32746 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL141592 32746 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44303852 101866 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL303755 101866 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
18950586 15373 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
CHEMBL122017 15373 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
44377058 119488 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350121 119488 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
10482937 166573 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL321086 166573 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL429058 166573 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
14956757 67236 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
CHEMBL19018 67236 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
14956757 67236 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
CHEMBL19018 67236 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
4189 205185 91 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205185 91 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205185 91 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
71455883 83336 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
CHEMBL2205685 83336 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
44372686 96194 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
CHEMBL263714 96194 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
44211677 130079 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL368149 130079 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
164623569 185595 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1008 26 12 10 2.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4872735 185595 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1008 26 12 10 2.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
44348302 16299 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
CHEMBL123562 16299 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
11764826 97819 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL274710 97819 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
44348302 16299 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
CHEMBL123562 16299 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
10028460 116008 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
CHEMBL336180 116008 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
10349512 206257 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97332 206257 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
19385665 50773 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
CHEMBL15788 50773 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
10028815 206345 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL97783 206345 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL411657 211197 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CSS2)N(C(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C1 10.1021/jm00065a013
10078397 11988 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL1184032 11988 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL329290 11988 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
168298448 192092 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 477 5 2 4 5.8 O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
CHEMBL5219534 192092 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 477 5 2 4 5.8 O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
44211576 106621 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 10 1 9 5.2 CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL316063 106621 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 10 1 9 5.2 CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
136059721 188401 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1537 12 10 33 3.3 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL508699 188401 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1537 12 10 33 3.3 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
10429298 18699 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128416 18699 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44300838 196983 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57976 196983 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10009968 112042 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
CHEMBL329942 112042 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
10372341 167624 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
CHEMBL433375 167624 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
16725318 188366 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1494 11 9 32 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL508306 188366 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1494 11 9 32 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
192626 15468 13 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
CHEMBL122212 15468 13 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
9978845 130177 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL36846 130177 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL417584 211477 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
9939191 98476 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98476 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98476 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
10326972 111756 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
CHEMBL329099 111756 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
10077555 205667 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
CHEMBL93956 205667 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
19102815 206132 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 206132 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
19385603 98311 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278234 98311 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL408885 210979 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
19754062 102499 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306641 102499 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10349029 206346 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
CHEMBL97812 206346 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
9888865 57180 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL165974 57180 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
10055448 30532 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139582 30532 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44379334 57789 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167584 57789 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
44381603 58789 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169798 58789 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
133031 100379 16 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
CHEMBL293511 100379 16 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
133031 100379 16 None - 1 Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
CHEMBL293511 100379 16 None - 1 Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
19385675 51084 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15816 51084 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
44311537 101849 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303647 101849 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311580 102293 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305238 102293 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311182 102540 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307008 102540 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311619 102583 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307359 102583 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311185 103701 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL309790 103701 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311073 202490 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70843 202490 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311184 202706 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL72099 202706 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311183 202984 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74069 202984 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311735 203034 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74514 203034 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9937227 200477 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60942 200477 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1016/S0960-894X(01)80554-0
9851082 100538 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL294512 100538 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
9987283 161381 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 705 16 1 9 6.7 CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL415502 161381 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 705 16 1 9 6.7 CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
133031 100379 16 None - 1 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL293511 100379 16 None - 1 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
9937227 200477 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm9504722
CHEMBL60942 200477 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm9504722
10032820 116788 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 116788 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10372659 117574 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 117574 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 104393 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104393 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
44381402 58838 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169967 58838 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
15780064 99149 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL284123 99149 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44381671 119908 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353800 119908 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
15292113 95574 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 95574 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10032858 29533 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
CHEMBL138690 29533 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
9853391 116326 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116326 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439715 116521 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 116521 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10350123 57283 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
CHEMBL1668007 57283 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
19939418 107771 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL319730 107771 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
19939495 206080 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 206080 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10395335 116568 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116568 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44315144 96131 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96131 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44381527 58750 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169568 58750 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
44210588 119826 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353037 119826 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10440144 116381 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116381 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462573 116495 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 116495 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44382947 58906 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 813 19 4 12 6.4 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/S0960-894X(00)80690-3
CHEMBL170290 58906 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 813 19 4 12 6.4 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/S0960-894X(00)80690-3
10101608 116515 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 116515 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372451 116778 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 116778 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010164 116881 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 116881 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101284 205659 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 205659 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
9850834 154112 13 None - 1 Rat 8.4 pIC50 = 8.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL39959 154112 13 None - 1 Rat 8.4 pIC50 = 8.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10032988 116404 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116404 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44321825 106613 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL316021 106613 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44309700 102697 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308237 102697 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10433752 18718 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128527 18718 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44283372 99941 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
CHEMBL290286 99941 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
9875044 206279 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
CHEMBL97446 206279 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
44303835 101283 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)81007-6
CHEMBL299887 101283 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)81007-6
44283372 99941 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm9504722
CHEMBL290286 99941 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm9504722
44311609 102322 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305369 102322 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311428 102483 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306473 102483 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311583 202411 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70353 202411 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
11740800 18634 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 385 4 1 2 4.2 Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
CHEMBL128065 18634 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 385 4 1 2 4.2 Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
10386376 18733 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 402 4 1 3 4.5 CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 10.1021/jm00077a001
CHEMBL128594 18733 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 402 4 1 3 4.5 CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 10.1021/jm00077a001
9939191 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL279629 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL97539 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
44323387 105494 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 600 11 2 8 5.6 CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL313142 105494 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 600 11 2 8 5.6 CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323364 111395 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 599 10 1 8 6.6 CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328780 111395 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 599 10 1 8 6.6 CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44311758 202955 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL73780 202955 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
9939191 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
44379350 120259 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355443 120259 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
9939191 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL279629 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL97539 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
9939191 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL279629 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97539 98476 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10348847 112080 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
CHEMBL330170 112080 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
10054912 205888 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
CHEMBL95197 205888 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
10054827 163575 0 None - 1 Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL42101 163575 0 None - 1 Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19385729 50591 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15774 50591 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
15818746 123538 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL36324 123538 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311775 102527 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306923 102527 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303636 168521 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 418 8 1 6 4.2 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(01)80554-0
CHEMBL439936 168521 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 418 8 1 6 4.2 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(01)80554-0
44311681 102536 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306961 102536 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44384870 59716 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173643 59716 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
44270285 98595 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL280456 98595 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
9980304 98071 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
CHEMBL276381 98071 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
10258916 29483 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL138654 29483 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
14952906 100026 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] 10.1021/jm00108a043
CHEMBL291086 100026 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] 10.1021/jm00108a043
11764788 100378 0 None - 1 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
CHEMBL293501 100378 0 None - 1 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
10439253 111816 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
CHEMBL329255 111816 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
164611280 184406 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4854474 184406 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10077328 204736 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 601 11 1 9 6.0 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88170 204736 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 601 11 1 9 6.0 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44315060 102570 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 102570 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44404967 134882 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL372814 134882 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
44323345 106508 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 557 10 1 8 5.6 CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315302 106508 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 557 10 1 8 5.6 CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10372723 106821 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL317368 106821 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
15231094 138754 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL37919 138754 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44309719 202147 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68638 202147 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
44323365 111570 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparationIn vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparation
ChEMBL 619 11 1 8 6.9 CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328997 111570 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparationIn vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparation
ChEMBL 619 11 1 8 6.9 CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379270 56547 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164395 56547 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10010027 206282 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97465 206282 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
130762 97782 9 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL274447 97782 9 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00053a013
44270306 51883 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15882 51883 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
5311345 2960 39 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
597 2960 39 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
CHEMBL321820 2960 39 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
10394712 118859 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344467 118859 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
122189454 122727 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 497 7 1 5 4.1 COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C 10.1016/j.bmc.2015.07.045
CHEMBL3613974 122727 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 497 7 1 5 4.1 COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C 10.1016/j.bmc.2015.07.045
5311345 2960 39 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
597 2960 39 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
CHEMBL321820 2960 39 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
44379217 57826 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167929 57826 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
15287883 97745 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL274260 97745 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
10461785 11803 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL1182712 11803 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL262296 11803 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
10032342 206272 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
CHEMBL97394 206272 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
44303941 201555 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 580 13 1 5 6.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64575 201555 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 580 13 1 5 6.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
22402431 48820 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 575 8 1 4 6.8 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156165 48820 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 575 8 1 4 6.8 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 10.1016/S0960-894X(01)81122-7
44384871 128785 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL367095 128785 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
18950609 16213 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
CHEMBL123084 16213 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
44321626 105473 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 616 14 3 9 4.8 CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL313005 105473 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 616 14 3 9 4.8 CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
9809961 106664 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316300 106664 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
9809961 106664 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL316300 106664 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9809961 106664 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
CHEMBL316300 106664 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
44323350 106523 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315400 106523 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
57380414 70171 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947131 70171 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10028545 20790 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
CHEMBL131156 20790 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
10009273 106728 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL316706 106728 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
15236320 172027 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL449095 172027 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
44315059 202996 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 202996 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
2911265 100362 13 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 476 4 0 2 6.5 O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL293414 100362 13 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 476 4 0 2 6.5 O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
183134 203126 13 None - 1 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL7550 203126 13 None - 1 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
9938088 101995 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
CHEMBL304022 101995 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
15230315 54137 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 552 8 0 7 5.7 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL160930 54137 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 552 8 0 7 5.7 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
14403498 100549 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81007-6
CHEMBL294558 100549 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81007-6
44322234 204971 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 8 5.1 CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89769 204971 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 8 5.1 CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
9986299 157893 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
CHEMBL409058 157893 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
44322235 112139 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 7 6.0 CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL330302 112139 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 7 6.0 CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10032193 118627 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342843 118627 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44211506 57222 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166338 57222 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44311456 101815 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303427 101815 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
71611145 184269 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4852514 184269 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44303195 201514 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL64411 201514 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 10.1016/S0960-894X(01)80554-0
44331176 206604 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 7.8 CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL99438 206604 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 7.8 CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10010311 30297 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139325 30297 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10327728 97658 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 97658 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439819 169311 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169311 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9850834 154112 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL39959 154112 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
9850834 154112 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL39959 154112 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
9850834 154112 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL39959 154112 13 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
19102786 205450 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL92533 205450 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
44309702 202036 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67805 202036 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10439837 16162 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16162 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10462598 113624 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 113624 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10327537 116164 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337118 116164 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10439848 118692 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343309 118692 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9852499 119944 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354080 119944 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
44314761 102368 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102368 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
44315350 104726 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 104726 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44304123 198883 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL59913 198883 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44210585 119888 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
CHEMBL353615 119888 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
10327309 113379 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113379 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
44322096 97936 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 622 12 4 8 4.8 CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL275449 97936 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 622 12 4 8 4.8 CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10259411 30428 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139452 30428 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL408886 210980 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 10.1021/jm00065a013
22402420 48782 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 521 9 1 4 5.5 COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156129 48782 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 521 9 1 4 5.5 COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
19939454 205813 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL94793 205813 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
10003751 18635 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128066 18635 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
5311348 100193 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm00077a001
CHEMBL292277 100193 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm00077a001
10455982 116134 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 441 8 1 2 5.6 CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
CHEMBL336991 116134 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 441 8 1 2 5.6 CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
10435148 117618 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 477 6 1 3 5.5 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL340778 117618 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 477 6 1 3 5.5 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
44303430 100552 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 541 12 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL294578 100552 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 541 12 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 10.1016/S0960-894X(01)80554-0
44303878 98225 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 5 1 3 4.3 CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C 10.1016/S0960-894X(01)81007-6
CHEMBL277567 98225 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 5 1 3 4.3 CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C 10.1016/S0960-894X(01)81007-6
22402433 49316 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 2 5 5.2 COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156587 49316 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 2 5 5.2 COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
9851082 100538 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL294512 100538 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
44311543 103651 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309455 103651 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10410436 117288 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 430 5 1 3 4.4 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL340187 117288 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 430 5 1 3 4.4 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 10.1021/jm00077a001
18950592 16596 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
CHEMBL124541 16596 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
44309902 102629 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL307757 102629 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
44311663 202479 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70796 202479 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311569 202988 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL74113 202988 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44381714 58794 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169827 58794 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
10416501 111904 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL329759 111904 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
10349392 206300 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
CHEMBL97557 206300 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
44311607 202473 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70770 202473 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44211673 59393 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL172376 59393 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
44300826 197051 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL58291 197051 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10099830 107992 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL319955 107992 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
44270278 98395 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278983 98395 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
73349424 92185 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435833 92185 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44379268 119536 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL350554 119536 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10417431 108608 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
CHEMBL321363 108608 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
44322967 167368 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 712 15 1 10 7.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 10.1016/0960-894X(95)00477-B
CHEMBL431592 167368 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 712 15 1 10 7.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 10.1016/0960-894X(95)00477-B
10032583 12228 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL1185398 12228 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL411487 12228 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
3082918 94613 1 None - 0 Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL25528 94613 1 None - 0 Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
60148656 92181 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435829 92181 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44322233 111127 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 644 12 2 11 4.5 CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL328480 111127 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 644 12 2 11 4.5 CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10047444 99870 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL289543 99870 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
10010047 206202 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
CHEMBL97020 206202 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
164611656 184144 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1067 27 14 12 0.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4850726 184144 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1067 27 14 12 0.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
44348408 113061 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
CHEMBL332239 113061 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
10055096 97820 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL274712 97820 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10054188 205778 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL94582 205778 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
9939191 98476 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL279629 98476 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL97539 98476 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
9829012 92110 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24322 92110 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9829012 92110 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL24322 92110 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44376781 55964 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162859 55964 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
9829012 92110 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
CHEMBL24322 92110 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
9895635 111518 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
CHEMBL328941 111518 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
10484119 167534 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL432822 167534 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
10075750 107059 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL318891 107059 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44323291 204805 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.4 CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88600 204805 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.4 CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10095637 49682 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15689 49682 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
10009735 157648 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408798 157648 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
10004112 25311 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
CHEMBL135089 25311 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
44311683 105126 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL312301 105126 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311618 162773 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL419073 162773 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311581 167259 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL430792 167259 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311415 202377 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70161 202377 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311582 202498 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70868 202498 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44321790 204876 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 634 13 4 8 4.9 C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89052 204876 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 634 13 4 8 4.9 C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381656 119749 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352458 119749 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44330904 4265 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 698 19 1 8 7.3 CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL101039 4265 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 698 19 1 8 7.3 CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10373120 117085 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117085 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
15284887 164917 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 607 6 2 5 4.7 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O 10.1016/S0960-894X(00)80690-3
CHEMBL424004 164917 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 607 6 2 5 4.7 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O 10.1016/S0960-894X(00)80690-3
44381427 119754 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352503 119754 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10259525 15428 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15428 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987614 167997 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL435792 167997 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44321823 204487 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 696 13 4 8 6.1 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL86617 204487 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 696 13 4 8 6.1 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
19939753 202050 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67921 202050 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10100951 114533 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 114533 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44371045 119293 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 4 6.0 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL348363 119293 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 4 6.0 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
10344854 57285 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL1668009 57285 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O 10.1016/j.bmc.2010.10.043
10053595 102628 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307756 102628 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311638 102439 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306186 102439 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303230 198953 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59957 198953 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80554-0
44303232 201018 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 434 8 1 6 4.8 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl 10.1016/S0960-894X(01)80554-0
CHEMBL61754 201018 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 434 8 1 6 4.8 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl 10.1016/S0960-894X(01)80554-0
44311636 202420 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70389 202420 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222103 202824 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72819 202824 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
44376746 119341 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL348758 119341 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
44303230 198953 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL59957 198953 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
11764669 66471 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL18606 66471 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10233056 106662 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
CHEMBL316297 106662 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
10009478 111967 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
CHEMBL329858 111967 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
10032361 112216 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
CHEMBL330463 112216 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
10100723 205705 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL94176 205705 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44303230 198953 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL59957 198953 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
11741658 18610 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 399 4 0 3 4.3 COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL127844 18610 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 399 4 0 3 4.3 COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
108185 1578 71 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
586 1578 71 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
CHEMBL907 1578 71 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
1610 2305 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3941 2305 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3961 2305 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
590 2305 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
CHEMBL191 2305 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
DB00678 2305 89 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
183134 203126 13 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
CHEMBL7550 203126 13 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
44475943 188112 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1508 12 8 32 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL504492 188112 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1508 12 8 32 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
44309703 171976 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL448476 171976 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
10417031 106889 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
CHEMBL317864 106889 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
9986951 206022 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
CHEMBL95955 206022 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
10416422 206250 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97295 206250 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10416836 107405 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
CHEMBL319313 107405 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
9888876 48710 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15606 48710 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
73353934 92176 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435824 92176 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
10372093 112252 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
CHEMBL330533 112252 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
44376822 119535 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350493 119535 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
44274823 98605 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL280526 98605 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9830839 106435 0 None - 2 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
CHEMBL314812 106435 0 None - 2 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
44379183 120289 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355708 120289 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
11758341 116767 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1021/jm00019a005
CHEMBL339544 116767 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1021/jm00019a005
10326942 111888 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
CHEMBL329693 111888 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
10100074 112055 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL330007 112055 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
44379184 57133 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL165541 57133 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
44323351 106524 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315401 106524 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10394829 118842 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344387 118842 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10485202 118902 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344811 118902 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9873751 95960 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 614 12 1 8 5.9 CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL261981 95960 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 614 12 1 8 5.9 CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323290 106404 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 587 10 1 9 5.6 CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL314603 106404 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 587 10 1 9 5.6 CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44381431 58178 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168346 58178 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10078452 106781 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
CHEMBL317061 106781 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
44377123 119457 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349856 119457 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
10391038 116419 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1021/jm00019a005
CHEMBL338514 116419 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1021/jm00019a005
44309701 102698 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308238 102698 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
15230312 48635 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155987 48635 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
164620345 185621 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873167 185621 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10054324 97888 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL275160 97888 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
9908300 15356 0 None - 0 Rat 4.2 pIC50 = 4.2 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 387 8 2 5 3.9 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL12190 15356 0 None - 0 Rat 4.2 pIC50 = 4.2 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 387 8 2 5 3.9 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
73357016 92177 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435825 92177 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL408773 210974 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 10.1021/jm00065a013
10462933 16687 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16687 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9850834 154112 13 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL39959 154112 13 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
9874508 202964 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 202964 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44210586 58688 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169221 58688 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10101690 116348 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116348 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395394 31649 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL140708 31649 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44314780 102591 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 102591 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10010207 29966 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139041 29966 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44315180 102410 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102410 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
19763341 61641 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 448 8 1 6 5.2 CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00137a004
CHEMBL177435 61641 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 448 8 1 6 5.2 CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00137a004
5311345 2960 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
597 2960 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
CHEMBL321820 2960 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
5311345 2960 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
597 2960 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
CHEMBL321820 2960 39 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
9804437 117549 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 463 6 1 3 5.6 O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340467 117549 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 463 6 1 3 5.6 O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
9915892 103130 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308703 103130 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10417351 206209 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL97075 206209 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
9895984 203031 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 203031 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9915892 103130 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL308703 103130 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19385644 98283 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL278061 98283 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
44311429 202900 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL73369 202900 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10318033 117757 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 387 4 2 3 3.6 O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340933 117757 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 387 4 2 3 3.6 O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311342 101698 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL302760 101698 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222094 102488 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306489 102488 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222101 158004 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL409170 158004 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
44311688 103706 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309820 103706 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
14952909 147531 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O 10.1021/jm00108a043
CHEMBL39349 147531 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O 10.1021/jm00108a043
73357018 92186 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435834 92186 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
19385598 98393 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
CHEMBL278955 98393 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
44379291 119994 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354535 119994 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
14952916 99671 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 10.1021/jm00108a043
CHEMBL287762 99671 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 10.1021/jm00108a043
44384872 59665 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173455 59665 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL440063 212099 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44315349 60056 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60056 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315350 104726 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 104726 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10259334 206288 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
CHEMBL97500 206288 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
114899 2959 11 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
596 2959 11 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
CHEMBL1188080 2959 11 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
5311348 100193 3 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm9504722
CHEMBL292277 100193 3 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm9504722
44379086 56269 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164174 56269 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44311074 104408 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311253 104408 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9938088 101995 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1016/S0960-894X(01)80554-0
CHEMBL304022 101995 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1016/S0960-894X(01)80554-0
9851889 101591 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 101591 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44303883 201204 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62744 201204 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9938088 101995 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
CHEMBL304022 101995 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
44382994 96443 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 933 25 7 10 5.8 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 10.1016/S0960-894X(00)80690-3
CHEMBL265790 96443 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 933 25 7 10 5.8 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 10.1016/S0960-894X(00)80690-3
CHEMBL384125 210560 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44381657 58734 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169488 58734 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10372550 163953 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 163953 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314823 161326 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161326 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44314822 102463 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102463 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44303885 201205 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 538 12 1 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62754 201205 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 538 12 1 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10413312 116795 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 1 3 5.8 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL339706 116795 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 1 3 5.8 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
10344278 117667 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 117667 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44323559 205273 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 628 10 1 9 4.9 CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL91465 205273 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 628 10 1 9 4.9 CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44311451 103612 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309367 103612 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
18655106 198775 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
CHEMBL59854 198775 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
15296723 48586 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 7 1 4 5.2 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155938 48586 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 7 1 4 5.2 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 10.1016/S0960-894X(01)81122-7
14403498 100549 3 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm9504722
CHEMBL294558 100549 3 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm9504722
164612059 183909 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1123 30 14 12 1.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4847398 183909 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1123 30 14 12 1.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
44303614 198973 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 478 8 1 6 4.9 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
CHEMBL59974 198973 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 478 8 1 6 4.9 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
15222070 101814 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL303426 101814 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311648 202812 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72721 202812 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10349256 110955 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
CHEMBL327569 110955 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
10461595 206370 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
CHEMBL97964 206370 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
10254358 116979 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 475 6 0 3 5.5 COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340018 116979 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 475 6 0 3 5.5 COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311472 103303 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308943 103303 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377199 57103 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165349 57103 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
73353933 92173 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435821 92173 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10078132 106754 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
CHEMBL316904 106754 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
10078048 106384 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
CHEMBL314514 106384 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
10411441 51498 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15850 51498 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
15230316 119574 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 522 7 1 6 5.3 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL350875 119574 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 522 7 1 6 5.3 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
44348259 15841 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
CHEMBL122367 15841 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
1610 2305 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3941 2305 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3961 2305 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
590 2305 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
CHEMBL191 2305 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
DB00678 2305 89 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
1610 2305 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3941 2305 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3961 2305 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
590 2305 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
CHEMBL191 2305 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
DB00678 2305 89 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
10393837 167370 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
CHEMBL431619 167370 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
44211672 157649 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408799 157649 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
9892451 48461 17 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
CHEMBL155836 48461 17 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
15296726 51579 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 2 5 5.1 COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL158557 51579 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 2 5 5.1 COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
18950598 15352 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
CHEMBL121891 15352 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
10483888 110954 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
CHEMBL327563 110954 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
18950607 50132 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15729 50132 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
9933755 54746 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16165 54746 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
73355475 92179 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435827 92179 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9807029 201406 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL63998 201406 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1016/S0960-894X(01)80554-0
9807029 201406 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
CHEMBL63998 201406 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
73347892 92175 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435823 92175 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
25135102 188273 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1495 12 10 32 3.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL507053 188273 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1495 12 10 32 3.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
10349801 107439 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL319353 107439 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
19385586 49443 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15669 49443 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
10414470 16933 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00019a005
CHEMBL125542 16933 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00019a005
44322176 204940 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 646 13 3 11 4.4 CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89463 204940 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 646 13 3 11 4.4 CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381622 58697 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169279 58697 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44315078 203038 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 203038 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19102815 206132 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 206132 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
44321775 106503 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 588 13 4 8 4.4 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315275 106503 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 588 13 4 8 4.4 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
10439858 16667 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16667 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
5311345 2960 39 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
597 2960 39 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
CHEMBL321820 2960 39 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
44381670 119965 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354298 119965 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
44315282 96163 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96163 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
10344278 117667 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 117667 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44303211 100119 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomesCompound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
CHEMBL291803 100119 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomesCompound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
44303404 198014 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59331 198014 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL264450 208864 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CCSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44311498 102444 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306216 102444 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222092 103334 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309165 103334 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44379182 57799 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167662 57799 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
9961192 11246 34 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL1179743 11246 34 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL97688 11246 34 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
10417102 205703 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
CHEMBL94145 205703 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
44303211 100119 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1021/jm9504722
CHEMBL291803 100119 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1021/jm9504722
18950608 15480 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
CHEMBL122224 15480 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
44311568 97719 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL273992 97719 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44270367 162660 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL418354 162660 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
44377111 119366 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349020 119366 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44210830 57166 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL165850 57166 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
10054708 106657 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
CHEMBL316273 106657 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
44304163 201088 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 496 17 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62157 201088 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 496 17 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10350378 206448 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
CHEMBL98453 206448 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
44574325 188154 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1521 12 8 32 4.8 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL505204 188154 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1521 12 8 32 4.8 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL413034 211290 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
9874086 108613 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
CHEMBL321367 108613 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
19939756 4954 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL105199 4954 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10349845 11242 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL1179731 11242 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL97271 11242 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
164627947 185793 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4875696 185793 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10426066 100029 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 318 7 1 3 4.0 CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL291114 100029 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 318 7 1 3 4.0 CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
44311454 102459 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306340 102459 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311436 202478 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70793 202478 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44303420 200048 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60661 200048 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 10.1016/S0960-894X(01)80554-0
44321804 105487 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 690 13 4 8 5.7 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL313073 105487 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 690 13 4 8 5.7 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL406290 210846 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
15292111 203027 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 203027 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315304 203291 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 203291 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
15230313 48335 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 446 6 1 4 4.3 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155728 48335 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 446 6 1 4 4.3 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
15292112 102462 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102462 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10368357 116755 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 7 1 3 5.5 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL339485 116755 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 7 1 3 5.5 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
10344278 117667 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 117667 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311739 102121 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL304137 102121 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44311662 102195 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
CHEMBL304620 102195 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
44311650 102713 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308361 102713 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
14952904 99688 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 396 9 2 5 4.8 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O 10.1021/jm00108a043
CHEMBL287936 99688 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 396 9 2 5 4.8 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O 10.1021/jm00108a043
44309704 202566 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL71253 202566 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
44300798 197267 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL58499 197267 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
9805344 98570 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL280290 98570 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
10372718 108057 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
CHEMBL320222 108057 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
9809280 203254 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL76525 203254 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL80370 203254 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
9809280 203254 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
CHEMBL76525 203254 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
CHEMBL80370 203254 6 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
19385623 50149 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15730 50149 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
44335530 107010 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL318605 107010 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
44323292 163239 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.2 CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL420607 163239 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.2 CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323363 111103 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 558 10 2 8 4.5 CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328340 111103 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 558 10 2 8 4.5 CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379185 57235 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166428 57235 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
19742811 57105 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165354 57105 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
56661223 62907 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791308 62907 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL2392353 208659 6 None - 1 Human 10.0 pKi = 10.0 Binding
Binding affinity to human AT2 receptor by radioligand displacement assayBinding affinity to human AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10079601 210774 17 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
CHEMBL404594 210774 17 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
10079601 210774 17 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL404594 210774 17 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL938 214120 24 None -1 2 Human 9.8 pKi = 9.8 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
CHEMBL216061 207561 10 None -1 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16133225 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
172198 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
2504 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
45266664 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
5272 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
CHEMBL408403 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
DB11842 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
16133225 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
172198 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
2504 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
45266664 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
5272 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
CHEMBL408403 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
DB11842 415 47 None -2 6 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
16133225 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
172198 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
2504 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
45266664 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
5272 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
CHEMBL408403 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
DB11842 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
16133225 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
172198 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
2504 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
45266664 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
5272 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
CHEMBL408403 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
DB11842 415 47 None -2 6 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
56661223 62907 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791308 62907 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
16133225 415 47 None -2 6 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
172198 415 47 None -2 6 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
2504 415 47 None -2 6 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
45266664 415 47 None -2 6 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
5272 415 47 None -2 6 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
CHEMBL408403 415 47 None -2 6 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
DB11842 415 47 None -2 6 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
CHEMBL938 214120 24 None -1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/ml500278g
CHEMBL938 214120 24 None -1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmcl.2015.10.084
6918 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
9804984 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
CHEMBL189568 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
6918 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
6918 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
9804984 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
9804984 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
CHEMBL189568 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
CHEMBL189568 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
6918 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
9804984 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
CHEMBL189568 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
6918 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
9804984 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
CHEMBL189568 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
11317806 123112 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 489 10 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 10.1021/jm049715t
CHEMBL361927 123112 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 489 10 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 10.1021/jm049715t
11994291 80301 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 485 12 1 7 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL215160 80301 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 485 12 1 7 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11994289 82051 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217673 82051 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
16133225 415 47 None -2 6 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
172198 415 47 None -2 6 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
2504 415 47 None -2 6 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
45266664 415 47 None -2 6 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
5272 415 47 None -2 6 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
CHEMBL408403 415 47 None -2 6 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
DB11842 415 47 None -2 6 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
CHEMBL404996 210782 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None CCSC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm030921v
CHEMBL3350599 209725 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
11994289 82051 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL217673 82051 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/acs.jmedchem.5b00982
11994289 82051 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL217673 82051 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL268815 209011 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm051222g
10463891 96453 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL265881 96453 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL268815 209011 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm0491492
CHEMBL424755 211566 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)O 10.1021/jm0613469
44398242 66865 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL187880 66865 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
10163396 81152 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 489 12 1 7 4.5 CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216250 81152 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 489 12 1 7 4.5 CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168283461 190379 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 10 1 8 4.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5186237 190379 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 10 1 8 4.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
16133225 415 47 None -2 6 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
172198 415 47 None -2 6 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
2504 415 47 None -2 6 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
45266664 415 47 None -2 6 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
5272 415 47 None -2 6 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
CHEMBL408403 415 47 None -2 6 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
DB11842 415 47 None -2 6 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
168273584 189609 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 503 8 1 10 4.2 CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5174659 189609 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 503 8 1 10 4.2 CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL268815 209011 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm049651m
9850834 154112 13 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL39959 154112 13 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
16087342 141169 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL385706 141169 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
11564291 166530 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1008 26 12 12 -0.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL428986 166530 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1008 26 12 12 -0.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
10160913 141263 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386269 141263 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11766283 71221 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 909 23 11 11 -0.2 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL196316 71221 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 909 23 11 11 -0.2 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
168270996 189456 0 None 64 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5172324 189456 0 None 64 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168291545 191383 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 597 10 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 10.1016/j.bmc.2022.116804
CHEMBL5201369 191383 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 597 10 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 10.1016/j.bmc.2022.116804
162660565 180730 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 9 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL4762752 180730 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 9 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL426885 211593 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)O 10.1021/jm0613469
56657702 62908 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791309 62908 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
168290795 191340 0 None 33 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5200734 191340 0 None 33 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168292515 191431 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 10.1016/j.bmc.2022.116804
CHEMBL5202149 191431 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 10.1016/j.bmc.2022.116804
118725967 116683 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
CHEMBL3394207 116683 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
118725967 116683 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
CHEMBL3394207 116683 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
168274956 189734 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 10 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5176607 189734 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 10 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10227337 81230 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216361 81230 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168296606 191840 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 587 11 1 6 8.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5208437 191840 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 587 11 1 6 8.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145963801 163498 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4209214 163498 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
11365721 98201 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 640 13 1 10 6.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1021/jm031031i
CHEMBL277388 98201 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 640 13 1 10 6.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1021/jm031031i
168287840 190702 0 None 32 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5191241 190702 0 None 32 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145978135 163326 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 9 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4207027 163326 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 9 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 10.1016/j.bmcl.2017.11.042
168295859 191677 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205969 191677 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
168288075 191056 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 595 12 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5196244 191056 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 595 12 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
11994292 81560 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 471 10 1 7 4.6 CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216515 81560 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 471 10 1 7 4.6 CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168285844 190963 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 8 1 8 4.2 CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5194914 190963 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 8 1 8 4.2 CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
44420775 137345 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 315 7 2 4 2.2 CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1021/jm0613469
CHEMBL376286 137345 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 315 7 2 4 2.2 CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1021/jm0613469
145965121 163863 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4213607 163863 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1016/j.bmcl.2017.11.042
11296725 99896 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 652 13 2 9 6.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289803 99896 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 652 13 2 9 6.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 10.1021/jm031031i
9830680 100163 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
CHEMBL292150 100163 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
162657895 180467 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 12 1 8 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4759641 180467 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 12 1 8 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 10.1016/j.bmc.2020.115859
56964910 77076 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/ml500278g
CHEMBL2086892 77076 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/ml500278g
56964910 77076 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
CHEMBL2086892 77076 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
162675267 182765 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 8 1 7 4.8 CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4797684 182765 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 8 1 7 4.8 CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
11764788 100378 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
CHEMBL293501 100378 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
158303357 191624 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 532 10 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205106 191624 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 532 10 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
166492461 191206 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 474 8 1 8 4.2 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5198482 191206 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 474 8 1 8 4.2 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
145977406 163285 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 487 8 1 7 5.2 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4206507 163285 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 487 8 1 7 5.2 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 10.1016/j.bmcl.2017.11.042
73213176 104209 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 454 9 2 6 2.6 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105392 104209 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 454 9 2 6 2.6 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2013.12.040
11995658 81712 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 364 6 1 6 4.0 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 10.1021/jm0606185
CHEMBL216746 81712 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 364 6 1 6 4.0 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 10.1021/jm0606185
168274734 190062 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 12 1 6 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5181652 190062 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 12 1 6 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
166492455 190804 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 7 1 8 4.4 CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5192639 190804 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 7 1 8 4.4 CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
3936 2171 28 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
6603900 2171 28 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL288174 2171 28 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
11994290 79975 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 441 9 1 6 4.4 CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 10.1021/jm0606185
CHEMBL214525 79975 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 441 9 1 6 4.4 CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 10.1021/jm0606185
CHEMBL268815 209011 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm030921v
10031067 99875 3 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL289614 99875 3 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL216331 207568 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm049651m
56657702 62908 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791309 62908 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
168277309 189624 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 448 8 1 8 3.7 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5174923 189624 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 448 8 1 8 3.7 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
3936 2171 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
6603900 2171 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
CHEMBL288174 2171 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
44400670 158334 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 993 23 12 13 -0.7 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL409528 158334 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 993 23 12 13 -0.7 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
3936 2171 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
6603900 2171 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
CHEMBL288174 2171 28 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
168277868 189873 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 10 1 8 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5178914 189873 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 10 1 8 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
145978497 163091 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 10 1 7 5.3 CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4204342 163091 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 10 1 7 5.3 CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145972310 164004 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 9 1 6 4.6 CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4215292 164004 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 9 1 6 4.6 CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
45102601 168993 9 None -1995 2 Human 5.6 pKi = 5.6 Binding
Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
CHEMBL4435800 168993 9 None -1995 2 Human 5.6 pKi = 5.6 Binding
Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
162651258 179745 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 13 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 10.1016/j.bmc.2020.115859
CHEMBL4751226 179745 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 13 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 10.1016/j.bmc.2020.115859
166492466 191335 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 8 1 8 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5200682 191335 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 8 1 8 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
56964910 77076 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
CHEMBL2086892 77076 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
56964910 77076 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL2086892 77076 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145967796 164270 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4218765 164270 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1016/j.bmcl.2017.11.042
67132863 77079 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 503 11 1 8 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
CHEMBL2086910 77079 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 503 11 1 8 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
145976243 162962 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 11 1 6 5.2 CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4202730 162962 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 11 1 6 5.2 CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
163408877 190095 2 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 490 7 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5182186 190095 2 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 490 7 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
168277087 189882 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 505 10 1 6 5.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5179052 189882 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 505 10 1 6 5.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145969149 164206 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 9 1 7 4.7 CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4217991 164206 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 9 1 7 4.7 CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
73213178 104210 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 483 10 3 6 2.4 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105394 104210 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 483 10 3 6 2.4 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2013.12.040
10057017 161266 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm030921v
CHEMBL414478 161266 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm030921v
10057017 161266 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm0491492
CHEMBL414478 161266 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm0491492
168272246 189888 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 477 10 1 8 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5179119 189888 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 477 10 1 8 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 10.1016/j.bmc.2022.116790
10196520 67287 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 553 11 1 7 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1021/jm049715t
CHEMBL190577 67287 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 553 11 1 7 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1021/jm049715t
6918 1010 29 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
9804984 1010 29 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL189568 1010 29 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
44398381 67249 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL190286 67249 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
10054827 163575 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL42101 163575 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
145978684 162997 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 445 9 1 6 4.5 CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4203099 162997 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 445 9 1 6 4.5 CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145974498 164163 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4217484 164163 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
168287782 191218 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5198739 191218 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10277322 141244 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386172 141244 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11274375 99983 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 804 16 1 9 9.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL290708 99983 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 804 16 1 9 9.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
163409135 189580 2 None -37 2 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
CHEMBL5174180 189580 2 None -37 2 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
11216369 99893 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289775 99893 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
11994293 81875 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.9 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217208 81875 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.9 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
145976532 163043 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 443 8 1 6 4.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4203624 163043 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 443 8 1 6 4.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 10.1016/j.bmcl.2017.11.042
168279676 190525 0 None 11 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5188126 190525 0 None 11 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
166492421 190021 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 545 11 1 10 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5181087 190021 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 545 11 1 10 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
10116410 140975 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL384577 140975 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11445913 133086 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 908 19 10 12 0.3 C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL371395 133086 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 908 19 10 12 0.3 C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
16124929 83018 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 2 4 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 10.1021/jm0613469
CHEMBL219840 83018 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 2 4 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 10.1021/jm0613469
166492441 190899 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 504 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5193845 190899 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 504 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
162666037 181720 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 14 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 10.1016/j.bmc.2020.115859
CHEMBL4784233 181720 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 14 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 10.1016/j.bmc.2020.115859
8374 2866 36 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
9937291 2866 36 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL34124 2866 36 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
DB16266 2866 36 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
145964638 163820 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 11 1 7 5.5 CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4213069 163820 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 11 1 7 5.5 CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
168274602 189772 0 None 97 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5177359 189772 0 None 97 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
9806878 126985 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 525 10 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1021/jm049715t
CHEMBL366210 126985 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 525 10 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1021/jm049715t
11995655 140953 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 10 1 6 5.0 CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL384462 140953 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 10 1 6 5.0 CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
44212339 203317 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 438 7 1 6 4.9 CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL77029 203317 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 438 7 1 6 4.9 CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
168297670 191770 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 615 10 1 6 7.8 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
CHEMBL5207511 191770 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 615 10 1 6 7.8 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
11181498 100030 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 680 14 1 9 6.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL291124 100030 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 680 14 1 9 6.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
16087341 96420 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL265613 96420 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
16124928 83017 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 3 3 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 10.1021/jm0613469
CHEMBL219839 83017 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 3 3 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 10.1021/jm0613469
11180576 99835 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 566 11 1 7 6.6 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL289306 99835 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 566 11 1 7 6.6 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
145972980 163931 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 433 7 1 7 3.9 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4214477 163931 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 433 7 1 7 3.9 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145972801 164039 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4215828 164039 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
166492420 191650 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 559 11 1 10 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205556 191650 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 559 11 1 10 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
11722069 70208 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 895 22 11 11 0.1 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL194864 70208 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 895 22 11 11 0.1 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
73213175 104208 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 397 8 2 6 3.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 10.1016/j.bmcl.2013.12.040
CHEMBL3105391 104208 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 397 8 2 6 3.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 10.1016/j.bmcl.2013.12.040
166492452 190171 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 502 11 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5183386 190171 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 502 11 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
145966800 163463 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 5.1 CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4208670 163463 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 5.1 CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
11366289 167439 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 784 18 1 9 9.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL432095 167439 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 784 18 1 9 9.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 10.1021/jm031031i
168283187 190613 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 639 11 1 6 8.4 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5189691 190613 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 639 11 1 6 8.4 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10396262 114922 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1022 27 12 12 0.3 CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
CHEMBL3350600 114922 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1022 27 12 12 0.3 CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16125001 105937 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
CHEMBL3105395 105937 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
CHEMBL3139603 105937 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
11331641 99825 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289211 99825 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
67133138 77080 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 12 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 10.1016/j.bmc.2020.115859
CHEMBL2086911 77080 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 12 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 10.1016/j.bmc.2020.115859
10742620 57282 0 None -16 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668003 57282 0 None -16 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
163409136 190298 2 None -18 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5185088 190298 2 None -18 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
145965943 163641 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4210874 163641 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
131590 20488 37 None -16 3 Human 6.3 pKi = 6.3 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
CHEMBL130896 20488 37 None -16 3 Human 6.3 pKi = 6.3 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
10276878 79997 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 11 1 6 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL214592 79997 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 11 1 6 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
10140383 81964 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 11 1 7 5.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217249 81964 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 11 1 7 5.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168271055 189335 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 588 11 1 8 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5170220 189335 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 588 11 1 8 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168272577 189751 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 10 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5176951 189751 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 10 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168277414 189859 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 517 8 1 10 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5178751 189859 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 517 8 1 10 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
166492465 189943 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 11 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5179875 189943 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 11 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
162650706 179448 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 515 10 1 8 5.0 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL4747530 179448 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 515 10 1 8 5.0 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
16087340 165373 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 912 21 10 11 1.2 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL425077 165373 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 912 21 10 11 1.2 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
168292360 191270 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 581 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5199606 191270 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 581 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168278021 189589 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
CHEMBL5174301 189589 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
11994156 81703 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 10 1 7 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216688 81703 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 10 1 7 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
162663560 181346 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 11 1 8 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4779819 181346 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 11 1 8 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
56678310 62906 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1034 25 11 12 1.0 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm030921v
CHEMBL1791259 62906 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1034 25 11 12 1.0 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm030921v
10140382 141332 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1021/jm0606185
CHEMBL386671 141332 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1021/jm0606185
9891811 119224 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL347703 119224 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL4524047 119224 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
10289461 67411 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 526 10 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 10.1021/jm049715t
CHEMBL190811 67411 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 526 10 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 10.1021/jm049715t
162663467 181360 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 9 1 8 5.4 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4779945 181360 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 9 1 8 5.4 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
11316477 67737 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 434 9 1 6 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 10.1021/jm049715t
CHEMBL191468 67737 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 434 9 1 6 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 10.1021/jm049715t
163848227 189508 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 10 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5173054 189508 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 10 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
145965035 163688 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 529 10 1 7 5.6 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4211391 163688 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 529 10 1 7 5.6 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmcl.2017.11.042
132404 119268 11 None -36 2 Human 6.1 pKi = 6.1 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
CHEMBL348126 119268 11 None -36 2 Human 6.1 pKi = 6.1 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
10161763 80300 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1021/jm0606185
CHEMBL215159 80300 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1021/jm0606185
10300357 141170 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 495 11 1 7 4.3 CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL385714 141170 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 495 11 1 7 4.3 CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
4189 205185 91 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 205185 91 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 205185 91 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10182998 141340 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.7 CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386718 141340 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.7 CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
132840 104997 18 None -3311 3 Rat 4.1 pKi = 4.1 Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenalIn vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL312104 104997 18 None -3311 3 Rat 4.1 pKi = 4.1 Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenalIn vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
11239632 99675 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 748 15 1 10 8.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL287829 99675 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 748 15 1 10 8.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 10.1021/jm031031i
118725969 116684 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
CHEMBL3394209 116684 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
11251114 158628 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 714 14 2 9 7.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL409843 158628 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 714 14 2 9 7.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
73213179 104213 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 511 10 3 6 3.0 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2013.12.040
CHEMBL3105465 104213 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 511 10 3 6 3.0 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2013.12.040
10205901 82087 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 11 1 8 4.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217752 82087 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 11 1 8 4.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168294859 191668 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5205769 191668 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
44400615 156064 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1007 22 11 13 0.4 CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL406907 156064 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1007 22 11 13 0.4 CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
162670036 182064 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 517 8 1 8 5.0 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4788892 182064 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 517 8 1 8 5.0 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
168275495 189867 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5178838 189867 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
11672486 98046 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL276163 98046 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
166492458 190968 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 516 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5195051 190968 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 516 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
6918 1010 29 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
9804984 1010 29 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
CHEMBL189568 1010 29 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
73213180 104214 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 499 11 3 7 2.1 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105466 104214 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 499 11 3 7 2.1 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 10.1016/j.bmcl.2013.12.040
73213252 104215 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 434 11 2 6 2.3 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC 10.1016/j.bmcl.2013.12.040
CHEMBL3105467 104215 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 434 11 2 6 2.3 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC 10.1016/j.bmcl.2013.12.040
1610 2305 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2305 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2305 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2305 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2305 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2305 89 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
1037 1542 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
3940 1542 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
5281037 1542 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
588 1542 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
CHEMBL813 1542 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
DB00876 1542 65 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
2583 3705 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
592 3705 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
65999 3705 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
CHEMBL1017 3705 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
DB00966 3705 115 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
16133225 415 47 None -2 6 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
172198 415 47 None -2 6 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
2504 415 47 None -2 6 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
45266664 415 47 None -2 6 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
5272 415 47 None -2 6 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
CHEMBL408403 415 47 None -2 6 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
DB11842 415 47 None -2 6 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
16133225 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
16133225 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
172198 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
172198 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
2504 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
2504 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
45266664 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
45266664 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
5272 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
5272 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
CHEMBL408403 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL408403 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
DB11842 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
DB11842 415 47 None -2 6 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
44299731 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
44299731 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
585 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
585 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
CHEMBL56448 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL56448 416 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
123794 878 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
123794 878 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
3944 878 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
3944 878 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
594 878 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
594 878 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL1885579 878 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
CHEMBL1885579 878 40 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
5311345 2960 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
5311345 2960 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
597 2960 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
597 2960 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
CHEMBL321820 2960 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
CHEMBL321820 2960 39 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
595 2935 0 None - 1 Rat 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2194459
16133225 415 47 125I-Angiotensin II 2 6 Pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
172198 415 47 125I-Angiotensin II 2 6 Pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
2504 415 47 125I-Angiotensin II 2 6 Pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
45266664 415 47 125I-Angiotensin II 2 6 Pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
5272 415 47 125I-Angiotensin II 2 6 Pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL408403 415 47 125I-Angiotensin II 2 6 Pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
DB11842 415 47 125I-Angiotensin II 2 6 Pig 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
4189 205185 91 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 205185 91 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 205185 91 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
36736 3405 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
598 3405 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
6324663 3405 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
CHEMBL356431 3405 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
6893 2813 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18207609
9987879 2813 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18207609
6894 414 0 None -1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
91691124 414 0 None -1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
6918 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
9804984 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
CHEMBL189568 1010 29 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
11931 1045 0 None 10 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
126456406 1045 0 None 10 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
11930 1002 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
15780052 1002 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
CHEMBL289472 1002 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944